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<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLE6</accession>
    <name>A0A068TLE6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00014285001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLE6"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLE6"/>
    <dbReference type="Gramene" id="CDO97061">
        <property type="protein sequence ID" value="CDO97061"/>
        <property type="gene ID" value="GSCOC_T00014285001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLE6"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLE6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
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    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="624"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="772"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011775"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PIRNR" id="PIRNR037093"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="CDO97061.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="889" mass="98660" checksum="05C392DF9F0A9941" modified="2014-10-01" version="1">MAQPLVKKDDDRDDEMDYSPFMGIEKGAVLQEARVFNDPQLDPRRCSQVITKLLYLLNQGETFTKIEATEVFFAVTKLFQSKDVGLRRMVYLMIKELSPSADEVIIVTSSLMKDMNSRTDMYRANAIRVLCRITDGTLLTQIERYLKQAIVDKNPVVASAALVSGIHLLQTNPEIVKRWSNEVQEAVQSRAALVQFHALGLLHQIRQNDRLAVSKLVTSLTRGTVRSPLAQCLLIRYTSQVIRESGMNNQTGERPFYDYLEGCLRHKAEMVIFEAARAITELSGVTSRELNPAITVLQLFLSSSKPVLRFAAVRTLNKVAMTHPTAVTNCNIDMESLISDQNRSIATLAITTLLKTGNESSVDRLMKQITNFMSDIADEFKIVVVEAIRSLCLKFPLKYRSLMNFLSNILREEGGFDYKKAIVDSIVILIRDIPDAKESGLLHLCEFIEDCEFTYLSTQILHFLGNEGPKTSDPSKYIRYIYNRVILENATVRAAAVSTLAKFGAMVDSLKPRIFILLKRCLFDNDDEVRDRATLYLNTLGGDGSVVETEGEVKEFLFGSFDVPLSNMETSLKNYIQDPSEESFDINSVPKEVKSQPLAEKKAPGKKPTGLGAPPSAPASAADAYEKLLLSIPEFATFGKLFKSSAPVELTEAETEYAVNVVKHIFDNHVVLQYNCTNTIPEQLLENVIVVVDASDAEEFAEIASKPLRSLPYDSPGQIFVAFEKPGGVPAVGKFSNVLRFIVKEVDPSTGEAEEDGVEDEYQLEDLEVVAADYMLKVGVSNFKNAWESMGSDFERLEEYGLGPRDSLTEAVNAVISLLGMQPCEGTEVVATNSRSHTCLLSGVFIGNVKVLVRLSFGIDAQKEVAMKLVVRSEDESVCVAIHEIVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN14</accession>
    <name>A0A068TN14_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014674001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN14"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN14"/>
    <dbReference type="Gramene" id="CDO97354">
        <property type="protein sequence ID" value="CDO97354"/>
        <property type="gene ID" value="GSCOC_T00014674001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN14"/>
    <dbReference type="OMA" id="HDVYAMA"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN14"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
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    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45926">
        <property type="entry name" value="OSJNBA0053K19.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="199"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="7">
        <location>
            <begin position="393"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="63954" checksum="C78F7BDD1DB28FF6" modified="2014-10-01" version="1">MASAVLASGNESSWAQSGGGFMGKLPYLNPNPNPNPKKKQKQFHPQAVNGGGRQNHDNSPAVTQTASDDAYSFNQIPTTEINRNGFNHGRYMTYNVTSYTKSELSELRKRLLSELEQIRNLRDRIESGHFSGCNSAHNPKSHGKSKKLPGNKRPIPVGSNKDPKRFPNGIDRAPGGNAGNSVDNEGLMKECRQILTKLMKHKNGWIFNAPVDAVNLGLHDYHQIVKRPMDLGTVKSNMAKYPSPAEFAADVRLTFNNSLLYNPKTDQVHGWAEFLLARFEELFRPIEEKIGNRRGFSGGGGSGFGGLVEELQGSSWNHIPTPERAKKPKSSPVVKKQERMQAHSSASTPSNPPPPLNPPKAQSPVPTPSPVRAPPAMPSQTAVRAAMTKQPKPRAKDPNKREMSMEEKHKLGIGLQSLPQEKMPQLVQIIRKRNEHLAQEGDEIELDIEALDTETLWELDRFVTNWKKMVSKTKRQALMMNNNNAAAVPSTSNAEVDGGAVSERNDSTKKPRKGEAGDEDVDIDDDMPATSFPPVEIEKDDGVGQDHGHASSSSSSSSSSSSDSSSSSDSDSGSSSGSDSDADDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN93</accession>
    <name>A0A068TN93_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00013976001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068TN93">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN93"/>
    <dbReference type="Gramene" id="CDO96828">
        <property type="protein sequence ID" value="CDO96828"/>
        <property type="gene ID" value="GSCOC_T00013976001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN93"/>
    <dbReference type="PhylomeDB" id="A0A068TN93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="121"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO96828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29979" checksum="B7573185FAF730D1" modified="2014-10-01" version="1">MEKVENLVELREAQDYAGTQIFNFRKCASLKCAIELGIPDVIAQHGKPIMLSGLISTLPINPSKSIHIHRLMRFLSNAGFFVQQNEGYSLSTAGRLLLKNEPFNMRAFIYYVSDPIALKPWNFLTEWFKNDDPSPFDTAHGKNFWSYAAAEPQFGKIFNEAMAGDSSLIVEVVVTQCKSVFEDLTSLVDVGGGTGEFAKAIVQNFPNLECLVCDLPHVVSNQQRTENLDFVAGNMLEMVPPGNAILLKVIRDIHPPCFNHLNFLRNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPI0</accession>
    <name>A0A068TPI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022198001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPI0"/>
    <dbReference type="FunCoup" id="A0A068TPI0">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPI0"/>
    <dbReference type="Gramene" id="CDO98185">
        <property type="protein sequence ID" value="CDO98185"/>
        <property type="gene ID" value="GSCOC_T00022198001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPI0"/>
    <dbReference type="OMA" id="YCDHISD"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000277">
        <property type="entry name" value="Leucine-rich repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000378">
        <property type="entry name" value="Leucine-rich repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000678">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="578" mass="62542" checksum="3685E880B973A767" modified="2014-10-01" version="1">MGGACSRKRDQQVDEDNIHRGFSGRYCKSGSSKWLGSSFSRSLSDVKQGIGKSPSLMELCTYKICEAIHNYGSFSMLPRDVSQQIFDELVYSQRLNDVILQAFRDCALQDLNLGEYPGFNDSWMDMIASQGSSLLSVDFSGSDVTDAGLSHLKDCTGLQALNFNYCDKISDNGMAHISGLSNMTTLSFRRNNMITAQGMSALSGLVNLVKLDLERCPKIHGGLVHLKGLTKLESLNINCCNCITDTDMKPLQGLANLKALQISSSKVTDHGVNFLKALHKLELLNMEGCPVTAACLESLSALGALLYLNLSRCNLADDGCDKFSRLQALKVLNLGFNEISDAILVYLKGLTNLESLNLDSCSIRDEGLVNLAGLSRLKCLELSDTEVGSSGLRHLSGLGNLESLNLSFTVVTDGGLRKLSGLSCLRSLNLDVRQITDTGLAALTSLTGLTHLDLFGARITDSGTNYLKCFRNLRSLEICGGGLTDAGVKNIKDLTSLALLNLSQNSHLTDKSLEAISGLTQLVSLNVSNSRVTSAGLQHLKPLKNLKSLTLESCKVTANDLKKLQATHLPNLVNFRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPL1</accession>
    <name>A0A068TPL1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022256001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPL1"/>
    <dbReference type="FunCoup" id="A0A068TPL1">
        <property type="interactions" value="1974"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPL1"/>
    <dbReference type="Gramene" id="CDO98230">
        <property type="protein sequence ID" value="CDO98230"/>
        <property type="gene ID" value="GSCOC_T00022256001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPL1"/>
    <dbReference type="OMA" id="YFRNTSQ"/>
    <dbReference type="OrthoDB" id="1680511at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPL1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35483:SF1">
        <property type="entry name" value="GLYCINE-RICH PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35483">
        <property type="entry name" value="NUCLEUSENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="263" mass="29154" checksum="2984BE4506D9EA35" modified="2014-10-01" version="1">MSCLQITVHQHCCNLTSVCHLRSASYVQCATPALQSVEPHKTSTTFNSNSSSYLGARLPKIAKKLSFGASGVQISTPVCLFGGKGKSENADEGSAWKALEKAMRNFGKEQSAEDVLRQQMLKQEYFDDGGSGGSGPGGGSGGSGGNGESEDESLSGILDELLQVILAAIGFVFLYMLIIEGEEITTFAKDIIRFLFTGRKSIRLRRLIDDWVRYFRSLSATKDEDPYWLERAILATPTWYDSPTKYKRMFRRYTSPRSYSRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ63</accession>
    <name>A0A068TQ63_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00022468001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ63"/>
    <dbReference type="STRING" id="49390.A0A068TQ63"/>
    <dbReference type="Gramene" id="CDO98391">
        <property type="protein sequence ID" value="CDO98391"/>
        <property type="gene ID" value="GSCOC_T00022468001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ63"/>
    <dbReference type="OMA" id="CTIMAVS"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF149">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="7">
        <location>
            <begin position="325"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="528" mass="59156" checksum="3F65ABBF8D08BB39" modified="2014-10-01" version="1">MYDPIFAKSFSKYEQKRFGFWAILVCTIMAVSIFLELKPGFHPLAILGNAMNLQLSIDAAQDKLAMKDEDISLPFGIHAVEQAKEGEQTDMLRVNDMGTSSPSATEAVESDPTNTSIVKDIDTNPPLATQAKKVETPSEELGEPACNFLGPLSDYCEIKGDIRIEANSSTVFIVSPQTTIAAKNKSWSTRPYARKGNGGAMISVKKWTIKLVSHNEDNIPRCSINHSIPSILFSTGGFSGNPFHDFSDLLVPIYSTSQEFGGEVQFLATDHQHWWISKYQMLFSRLSRHEIIAIDKEKEIHCYSRMVAGLKSYKEFIIDSSKFPHGLSMNHFRQFLRSTYSLERTRAIKLRKGGGQKPRLMLISRGRTRKLTNEGEITRMARKLGYEVIVAEAGLSTNLTSFAQLVNSCDVLMGVHGAGLTNMVFLPDKAILVQIIPLGGIDGLARVDFGIPSKDMNIRYLEYKIEATESSLIEQYPLDHAVFRDPSSFHKQGWGAIRSVYLDKQNVKIDLHRFKSTLVKALKLLRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS41</accession>
    <name>A0A068TS41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3700 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026145001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS41"/>
    <dbReference type="FunCoup" id="A0A068TS41">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TS41"/>
    <dbReference type="Gramene" id="CDO99115">
        <property type="protein sequence ID" value="CDO99115"/>
        <property type="gene ID" value="GSCOC_T00026145001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS41"/>
    <dbReference type="OMA" id="ANWSSQY"/>
    <dbReference type="OrthoDB" id="2019121at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd01910">
        <property type="entry name" value="Wali7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000061">
        <property type="entry name" value="Heat stress transcription factor A-6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024286">
        <property type="entry name" value="DUF3700"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044828">
        <property type="entry name" value="TSJT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45952">
        <property type="entry name" value="ALUMINUM INDUCED PROTEIN WITH YGL AND LRDR MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45952:SF4">
        <property type="entry name" value="ALUMINUM INDUCED PROTEIN WITH YGL AND LRDR MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12481">
        <property type="entry name" value="DUF3700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01172">
        <property type="entry name" value="DUF3700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3700" evidence="1">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="250" mass="27116" checksum="4D6469675BBB9BD7" modified="2014-10-01" version="1">MLAVFEKSVAKSPDALQTPNSESVSALKDGFLAQHFSSLQPGSVTINLGSSGFMAYSSDKQNPLLPRLFAVVDDIFCLFQGHIENVAHLKQQYGLNKIANEVIIVIEAYRSLRDRGPYPPDQVVRDIHGKFAFILYDSTAKTTFMAADVDGSVPFFWGTDSEGHLVVSTDLDVVKKGCGKSFAPFPKGCFFTSSGGLRSYEHPHNELKPVPRVDSSGEVCGANFKVDAEAKKGGTGMPRVGSAANWSQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSF3</accession>
    <name>A0A068TSF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00025869001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSF3"/>
    <dbReference type="FunCoup" id="A0A068TSF3">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSF3"/>
    <dbReference type="Gramene" id="CDO98909">
        <property type="protein sequence ID" value="CDO98909"/>
        <property type="gene ID" value="GSCOC_T00025869001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSF3"/>
    <dbReference type="OMA" id="FCHQVAA"/>
    <dbReference type="OrthoDB" id="1898688at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF8">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO98909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="196" mass="20617" checksum="A83A605C5D490463" modified="2014-10-01" version="1">MESQYIGSNGGLEGRGKEVEVANKSSLRGSDVILRFLAFASTLVAAIVLGVDKQTKLVSMTVVSTLPPITVPVTAKWHYMSAFVYFVVANVVACAYAALSLLLVLGNRGAKKGLALMIITLDLVMVALLSSGGGAALAVGLIGYRGNSHVQWNKVCNVFGRFCNQVAGAIVVSLLGSAAFLLLVLLAMINLHKKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSX8</accession>
    <name>A0A068TSX8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026484001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSX8"/>
    <dbReference type="STRING" id="49390.A0A068TSX8"/>
    <dbReference type="Gramene" id="CDO99351">
        <property type="protein sequence ID" value="CDO99351"/>
        <property type="gene ID" value="GSCOC_T00026484001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSX8"/>
    <dbReference type="OMA" id="IYDIPFT"/>
    <dbReference type="OrthoDB" id="672127at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSX8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF17">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="423" mass="48779" checksum="E4B9C56B2553C643" modified="2014-10-01" version="1">MSRIDQNLSDVLDTSEKPSIFKVHGPLRSENEEAYEPQVVSIGPYHHGKPKLKEMEKHKLRYFKEILRRRGESSAEKYIIALANLQDQARRCYAEEINLSEDDFVDMLCLDGCFVIEFLRKNQQPESCLENDHIFEMLWLPSTIAHDLVLFENQLPFFVLQKLFDMTKSPSGEENLIDLAIDLRLLWYFPDPGLNSHSTILEQYEEVHLLGLMHKILSASFSGTLSSTMNSNRGDSTLYIKSAGELGQSGIKFKKAEDSKSLFHITFENGVLKIPPLVVHDNTESFFRNLIAYEQYMSNPAEAWKCITGYMIFLDCLIDSPSDVERLRRHDIIENGLGSDEALSTMFNKLSKQVNSGGRFCYAKIFDDVDKYSRKRWHIWRAHLVRKYFNTPWSFIAFLAACALLLLATVQAIFSILQYTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUC9</accession>
    <name>A0A068TUC9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00029542001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUC9"/>
    <dbReference type="Gramene" id="CDO99846">
        <property type="protein sequence ID" value="CDO99846"/>
        <property type="gene ID" value="GSCOC_T00029542001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUC9"/>
    <dbReference type="OMA" id="NFRNCTE"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUC9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1392">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO99846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47943" checksum="0E08C4404341E830" modified="2014-10-01" version="1">MAQKPHVLIFPFPVQGHINCMLKLAELLCCRGLHVTFLNSHHIHERLLCCTDIHYHFSQYPSFHFETISDGLPADHPRTGDHILTGLQFHSPNGRPALTCIIADGIMSFTVDVAKELHIPTILFRTVSASCFWAFLCVPKLLEAGELPFNGENDMDKLLSSVPGLERFRMRDLPSFCRTSNLADPGFQVVISETLQNLKADGLLLNTFEDLEESALSHIRTHIPKLYTVGPLHAHLKAREASSPALQQPSSSSLWKEDRSCMAWLDRKPRNSVIYVSFGSMTVLTRNQLFEFWHGLVNSGKPFLWEVLAHPAVGGFLTHSGWNSTLESIYEGVPMICWPFYADQQVNSRLVGEVWKVGLDMKDTCERATVEKMIKDLMDVKRDEFMLCAKEKAKLARRSVEQAGSSHCNLDRLIDDINMMNRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV17</accession>
    <name>A0A068TV17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00029503001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV17"/>
    <dbReference type="FunCoup" id="A0A068TV17">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TV17"/>
    <dbReference type="Gramene" id="CDO99809">
        <property type="protein sequence ID" value="CDO99809"/>
        <property type="gene ID" value="GSCOC_T00029503001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV17"/>
    <dbReference type="OMA" id="WFSNNNA"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374:SF378">
        <property type="entry name" value="C2H2-TYPE ZINC FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374">
        <property type="entry name" value="ZINC FINGER PROTEIN ZAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO99809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="373" mass="41027" checksum="176356A96A3E1386" modified="2014-10-01" version="1">MVEAVEEVAGPQDLPHIVKGKRTKRQRPQSPIPFTITAQYSSSGEGGYVSNGDNCVNNVNNNTSNNNNHNNSSSSSAEEARPPDDHASNEEDEYTAKCLILLAQGGDVIKEPPAINKFDQAQEFGTEKFNSKRYIEAPISGNGKAGMYVYECKTCGRTFPSFQALGGHRASHKKPKNMAAAEEKKLYFDMSDDEEETIFKNGKNKSNYNNSSPLSLELINNNNRGTSSNSNLYKSASFPKIHECSHCGAEFPSGQALGGHMRRHRGAPAMTSTTLSLGQLSPEETTDQDSDEAEANKRTSNGLSLDLNLPAPEDDHHNKGPNKFSLASKHQQIPYQQHQQQNQKEEEEEKEAEAEAKPALVLSSTPKLVRCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVM8</accession>
    <name>A0A068TVM8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032187001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVM8"/>
    <dbReference type="STRING" id="49390.A0A068TVM8"/>
    <dbReference type="Gramene" id="CDP00296">
        <property type="protein sequence ID" value="CDP00296"/>
        <property type="gene ID" value="GSCOC_T00032187001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVM8"/>
    <dbReference type="PhylomeDB" id="A0A068TVM8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="149" mass="17187" checksum="42015B51426B6F0A" modified="2014-10-01" version="1">MGDLAHAKLRICEKKTEASDPCLADRIYAYLSNPGVQKALHVKTTRLHAAWTFCSELLDYQSDNIATNIIPLLSEILNRTCHTFVLQWRSRFKNPTDADKKNCKFVGQRTRAHSFWGIWSLVRWIAGKNAMITPWKHFSESQYSTLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYT0</accession>
    <name>A0A068TYT0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034721001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYT0"/>
    <dbReference type="STRING" id="49390.A0A068TYT0"/>
    <dbReference type="Gramene" id="CDP01172">
        <property type="protein sequence ID" value="CDP01172"/>
        <property type="gene ID" value="GSCOC_T00034721001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYT0"/>
    <dbReference type="OMA" id="LGGRECE"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="203" mass="21552" checksum="699F088C0BC30D30" modified="2014-10-01" version="1">MEVIVKKPLLTCAEGALSSIFTTATPPASLVNVQLLSLARDLFGWLAATEVKGKGNSDDQLKVVGAEQGDGDEQNDGGSDNGEGDFPDGEEEVAPEDGGGPGSNPNSSNGNAKKGPAGAGGAGDENGEEEDGEDGDGHNDRDDDDDDENQDDDDDEEEEEEEDDDREDEGDEEEVAEEDAEDEEEPEDEEEEEALQPPKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0C5</accession>
    <name>A0A068U0C5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Peroxidase</fullName>
            <ecNumber evidence="3 17">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00037161001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14 17">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="14 17">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="HG739091">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00037161001"/>
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        <property type="component" value="Chromosome IX"/>
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        <property type="entry name" value="Haem_peroxidase"/>
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        <property type="entry name" value="Haem_peroxidase_sf"/>
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        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
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        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
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        <property type="entry name" value="Secretory_peroxidase"/>
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        <property type="entry name" value="PEROXIDASE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104078" description="Peroxidase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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        <location>
            <position position="74"/>
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        <location>
            <position position="76"/>
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        <ligand>
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        <location>
            <position position="78"/>
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        <location>
            <position position="165"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <location>
            <position position="196"/>
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            <name>Ca(2+)</name>
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        <location>
            <position position="66"/>
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            <begin position="39"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP01966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="329" mass="36020" checksum="81AFBF00CE3C08C6" modified="2014-10-01" version="1">MTRPMSFLIIAAMLAFAPLCLCGMTSGGYLYPQFYDRTCPKAKEIVYSIVAKAVAREARMAASLIRLHFHDCFVKGCDASLLLDSSGAIISEKMSNPNRNSARGFEVIDEIKSALEKECPHTVSCADLLALAARDSTSGGPSWEVPLGRRDSRGASLSGSNSNIPAPNNTFQTILTKFKLQGLDIVDLVALSGSHTIGNSRCTSFRQRLYNQSGNGQPDFTLNQAYANQLRTRCPRSGGDQNLFVLDFVTPTKFDNSYFKNLLASKGLLNSDQVLVTKSAVSLQLVKQYAQNNQLFFEQFPKSMLKMANISPLTGSKGEIRKNCRTVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1D8</accession>
    <name>A0A068U1D8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00037190001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A068U1D8">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1D8"/>
    <dbReference type="Gramene" id="CDP01989">
        <property type="protein sequence ID" value="CDP01989"/>
        <property type="gene ID" value="GSCOC_T00037190001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1D8"/>
    <dbReference type="OMA" id="TPQPFRM"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1D8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000012">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF64">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654484" description="mannan endo-1,4-beta-mannosidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP01989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="432" mass="49138" checksum="72FD850242B2BF7C" modified="2014-10-01" version="1">MKHFLVVLLLFLLMQEKGFLLQVKAGDGFVRTGGIHFMLNNGPYYANGFNAYWLMYVASDPSQRSKVSAAFREASSHGLTVARTWAFNDGGYRALQYAPGAYNEQTFKGLDFVVAEARRYGIKLILSLANNYESFGGKKQYVDWARSRGQYLSSDDDFFRNSVVKGYYKNHIRTVLNRYNTFTGILYMNDPTIMAWELMNEPRCTSDPSGRTIQAWIMEMASYVKSIDRNHLLEAGLEGFYGQSTPQRTHLNPGLNIGTDFVANNRVPGIDFATVHSYPDIWLSSSNDQSQVSFMNQWLDAHFQDAQYMLGKPVMVAEFGKSSKDSGFSNYERDALFNDVYFKVYSSAKHGGPAAGALFWQLLTEGLDSFRDGYEIVLSQSPSTANVIAQQSYKLRLIQKIFTRMLNIKRWKRARAARGQWIDRNKGRHIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1T9</accession>
    <name>A0A068U1T9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox-leucine zipper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HD-ZIP protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Homeodomain transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00039421001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1T9"/>
    <dbReference type="FunCoup" id="A0A068U1T9">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP02129">
        <property type="protein sequence ID" value="CDP02129"/>
        <property type="gene ID" value="GSCOC_T00039421001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1T9"/>
    <dbReference type="OMA" id="FDASCHG"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1T9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009965">
        <property type="term" value="P:leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000159">
        <property type="entry name" value="Homeobox-leucine zipper protein HAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045224">
        <property type="entry name" value="HDZip_class_I_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326:SF497">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="279" mass="31619" checksum="51422E3E4B7EDEDC" modified="2014-10-01" version="1">MDSGRIYFDPSCHGNMLFLGSGNPVFPGARSVLNVEETLKRRPFLRSPEELFDEEYYEEQLAEKKRRLTPEQVHLLEKSFEAENKLEPERKTQLAKKLGLQPRQVAVWFQNRRARWKTKQLERDYDQVKSSYDSLRSDYDSVVKENEKLKTEVLSLTEKLQQGKEVVVEPRSKQKSDALPVDELLASDPQFNVKVEDRLSTGSGGSAVVDEDGPQLVDSGDSYFPCDDYAAGCVTPAADGVQSEEDDGSDNGQNYLSNVFVAAEQQNQEGEPVGWWVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1Y1</accession>
    <name>A0A068U1Y1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00039669001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP02312.1"/>
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    <sequence length="436" mass="48214" checksum="B310ECE9243260BC" modified="2014-10-01" version="1">MDIDGDAEEASRRIRVRFVTKLKPPYKAPPTSIAIPTNLTRFGLSALVNNLLKAGNADWKTEAFDFFIDGELVRMSLEEFLLAKGISAEKILEIEYIKAVAPRKKEDPSLHDDWVSAVDGSNPRFILTGCYDGFGRIWKTAGVCTHLLEGHTGAITSVCILDPLGSDGRRVVATASKDMTLRLFEVNTEEFQGQLKKIQSFKTLRGHNASVQCIAAKPSGAKICSGSWDCRINVWQANDSDSGGDFMSVKKRKVDIEDEEPKSEGEPISTLVGHTQCVSSVVWPEHETLYSASWDHSIRRWDVETGKDSMNMYCGKVINCLDVGGESSSLIAAGGSDPILRIWDPRKPGTLAPTFQFSSHTSWISGCKWHDNSWYHLVSASYDGKVMLWDLRTAWPLAVIDSHEDKVLCADWWKSNCVISGGADSKLCISSEISVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2F3</accession>
    <name>A0A068U2F3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-Gid-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040136001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">cv. DH200-94</strain>
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            <location evidence="1">Cytoplasm</location>
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        <property type="component" value="Chromosome IX"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="CTLH/CRA"/>
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        <property type="entry name" value="CTLH_C"/>
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        <property type="entry name" value="Fyv10_fam"/>
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        <property type="entry name" value="LisH"/>
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    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
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    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50089">
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    </dbReference>
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        <property type="entry name" value="ZF_RING_GID"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
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            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
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            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
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            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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            <dbReference type="EMBL" id="CDP02671.1"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43965" checksum="A734F5148FB7F513" modified="2014-10-01" version="1">MELNTIKDAFDRVTKKQKLSSSKSQEIIEQISQEIEQALSRIGPGDDIMTQTDPTFMLCELKAKLKEIGPHSQLEVTQKELNVALSKYPKLLEKSFNPDISKAYRNIDFDIHTVNQIIASHFYREGHFDLGDCFVHEAREPEAEAAKSSFAEMYQILEAMKLHNLEPALKWAATNHDQLNQNGSDIELKLHRLQFVEILQKKRRDEALNYAKTFLAPFAKSHMAEFQKLMGCLLWAGKLDASPYAELLSPVHWDKLSEELTRHFCNLMGQSFESPLSVTVAAGGQGLPTLLKLMNVMTGKKQEWQSMKQLPVPVDLDREFQFHSVFVCPVSRDQASEENPPMLLSCGHVLCKQSITKLSKNNSTRPFKCPYCPSEVEVGQCRQLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2K1</accession>
    <name>A0A068U2K1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00040174001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2K1"/>
    <dbReference type="FunCoup" id="A0A068U2K1">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2K1"/>
    <dbReference type="Gramene" id="CDP02706">
        <property type="protein sequence ID" value="CDP02706"/>
        <property type="gene ID" value="GSCOC_T00040174001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2K1"/>
    <dbReference type="OMA" id="KKQCTSA"/>
    <dbReference type="OrthoDB" id="687495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2K1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048766">
        <property type="term" value="P:root hair initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11454">
        <property type="entry name" value="bHLH_AtIND_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000046">
        <property type="entry name" value="Transcription factor bHLH83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45914:SF59">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45914">
        <property type="entry name" value="TRANSCRIPTION FACTOR HEC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="328" mass="35913" checksum="42E421E13CEF1C90" modified="2014-10-01" version="1">MELVKDHAPKRSTLCLIQPHPHYENDQFREVSQNAFPGLSSSDKSTGIPRNFGVTSPSSLSSPSSTNSDGLGYQQGIKTLPEDGNSVINFRGVYGDFANAGGSLLSFDHSQNSFPGIITTQDDYSVWEDNLHFTYQDQLNNSRCSTPNPRPLENSNNNQSSSSYASTSNGVPFGWHSTEVNANASKNNSIQDLGRQEACTSAKRPYTEESTQALKKQCTSVTKTTALKSKSTPSKDPQSVAAKNRRERISERLKILQDLVPNGSKVDLVTMLEKAISYVKFLQLQVKVLATDEFWPAQGAKAPDLSQVKEAIDAILASQRDRNSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2V1</accession>
    <name>A0A068U2V1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00041284001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2V1"/>
    <dbReference type="STRING" id="49390.A0A068U2V1"/>
    <dbReference type="Gramene" id="CDP02880">
        <property type="protein sequence ID" value="CDP02880"/>
        <property type="gene ID" value="GSCOC_T00041284001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2V1"/>
    <dbReference type="OMA" id="LNQHAWI"/>
    <dbReference type="OrthoDB" id="1894389at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2V1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055301">
        <property type="entry name" value="Lea14-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31852">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="2">
        <location>
            <begin position="100"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="215" mass="23921" checksum="BDE4D243CBBB2FFC" modified="2014-10-01" version="1">MAENGGEKVFAAATANPHGRGDEELASVAQREERRKKRMKYVAYGAAFVVFQTAVILVFSLVVMKVRTPKFRVRSATFQDFKAATLPTNSSFSTQMFAELSVKNPNFGRYKYQDSTVEFFYQNYKVGQAAIPKGKASFKSTKKFAVPVDLSSTNVPGDVLGSELNQHAWIPLTSRATLNGKVRLMLIFTKKKSTNMSCTMNLNTSSKQLQDLECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3J8</accession>
    <name>A0A068U3J8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MTD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041569001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3J8"/>
    <dbReference type="FunCoup" id="A0A068U3J8">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3J8"/>
    <dbReference type="Gramene" id="CDP03086">
        <property type="protein sequence ID" value="CDP03086"/>
        <property type="gene ID" value="GSCOC_T00041569001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3J8"/>
    <dbReference type="OMA" id="RPKPPCR"/>
    <dbReference type="OrthoDB" id="691484at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3J8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF96">
        <property type="entry name" value="PROTEIN OXIDATIVE STRESS 3 LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26080" checksum="F8255EA87FFAA20B" modified="2014-10-01" version="1">MYANGSKPPAPELGAAGAGVGAGRKVVEEEDEGRSGESSSSTSSIGRNSDEESSAGRSSEAGDGEEVQSEYKGGALDSLEALEEVLPIKRSISQFYFGKSKSFTSLSDAANCSSMKDIVKPENAYTRKRKNLLACNNFWDKNRNGIRRNNSGGISKRAAGSRSSLALAASMGCTESNNNSDSSNSNSPSRGICLPPLPPQARRSLYNDSLSPPGQKFSPWRSFSLSDLQGATATPSISGIMVNNRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3Z6</accession>
    <name>A0A068U3Z6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041690001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3Z6"/>
    <dbReference type="Gramene" id="CDP03186">
        <property type="protein sequence ID" value="CDP03186"/>
        <property type="gene ID" value="GSCOC_T00041690001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3Z6"/>
    <dbReference type="OMA" id="EDYNICG"/>
    <dbReference type="OrthoDB" id="1922121at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3Z6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038909">
        <property type="entry name" value="Effector_transcript"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35133">
        <property type="entry name" value="PROTEIN EFFECTOR OF TRANSCRIPTION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35133:SF1">
        <property type="entry name" value="PROTEIN EFFECTOR OF TRANSCRIPTION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19239">
        <property type="entry name" value="GIY_YIG_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="74900" checksum="41B33C7675E4F7BA" modified="2014-10-01" version="1">MESGERAPPSIILSVEAREKSVTALATISSSSRLKREDCRRTKHDSAFSPWKVLIGPSDWEDHSNGKEGAERYRTQNLPNCTSCTGVYELGTAVWRSKSRRDAGKLDPDFIIPVYLGKSDNVRNRLQQYGREGAHLENGSSNTKLNGCNGSLAQTGSGLFKDIFSEGFSIVYRWAPMKSTRDADKTESDLLGKFDYAWNKGSNGPRRHNDILKMLDRISKTSPFMAKLQVLSQRKKGIKIKAYKPPFVENGLDFYTSLETNGLLAQIFKFGRSQPRLIVRSVINENYISICGVALGHGVVCKRAPAEGNKRCTEHKGMKVNGFTSKLLKDGKSTLVANEYPINKTFTPPCGVILDDGSCCTSKPVQGNKRCLEHKGRKINNFPQLVNDKKANYVYGPVLDYNTSLSKAGHTDSSSTICGVDLDDGTFCTRQPPAGRKRCEEHKGKRIKETICISHRDEIPSSFIPSGPKIGIQESQNHSLIPSVFCGKTSPACGAATHDGSLCSRKPTEGNKRCWQHKGMRVDASPTSSSCNNSRRSSTSLQYASEDFTSTCGAALQNGSHCSRKPTNGNKRCSQHEGRRADLSPRSSNDFRYYANPFSYASHGSAYETFSSTCGAPTLGGSYCRRSTAGGRCWQHEGYANSYSYASYGSAYGNFSSTCGAPTRSGSYCRRSTAGGRCWQHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7T4</accession>
    <name>A0A068U7T4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00017502001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7T4"/>
    <dbReference type="STRING" id="49390.A0A068U7T4"/>
    <dbReference type="Gramene" id="CDP04189">
        <property type="protein sequence ID" value="CDP04189"/>
        <property type="gene ID" value="GSCOC_T00017502001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7T4"/>
    <dbReference type="OMA" id="RCNFASY"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7T4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05476">
        <property type="entry name" value="pepsin_A_like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000028">
        <property type="entry name" value="Eukaryotic aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000056">
        <property type="entry name" value="Eukaryotic aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034161">
        <property type="entry name" value="Pepsin-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF768">
        <property type="entry name" value="EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654555" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="91"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="500" mass="53544" checksum="D605A19250691AFC" modified="2014-10-01" version="1">MAPDLRRNGSVVALALLVSLVVNGVIFDVEGNNNVVFEVEHKFKGRRNENGGRGSFLTSLKAHDSHRHGRMLAALDMPLGGNGSPTDAALYFTKLSIGTPPQDYYVQVDTGSDILWVNCAGCVRCPKKSSLGIDLTLYDMKASSTGRLVTCDQDFCLSAFNAPASDCKVGNPCAYSVTYGDGSSTGGYFVRDYAKLNQLTGNLQTIPMNGSIVFGCSSQQSGELGSSTEAVDGIIGFGQANSSIISQLASAGKVKKIFSHCLDGINGGGIFAIGQVVQPKLKTTPLVPNEAHYNVVLNAIEVGGDVLNLPSDVLGGGSGSGTIIDSGTTLAYLPDDVYTPLMEKITASQSNLKIHIVENQFKCFVYSGNVDDGFPVVTFHFEDSLSLTVYPHEYLFDLHDDQWCIGWQNKGMQTRDGREVTLLGDLVLANKLVSYDLENQTIGWAEYNCSSSIKLRDEKSGNVYAVGSHIISSARGLNAGKALRFLLLIITSLLHALLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8U9</accession>
    <name>A0A068U8U9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CW-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00016576001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8U9"/>
    <dbReference type="FunCoup" id="A0A068U8U9">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8U9"/>
    <dbReference type="Gramene" id="CDP04043">
        <property type="protein sequence ID" value="CDP04043"/>
        <property type="gene ID" value="GSCOC_T00016576001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8U9"/>
    <dbReference type="OMA" id="TNTHEWK"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8U9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000006">
        <property type="entry name" value="B3 domain-containing transcription repressor VAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057743">
        <property type="entry name" value="Zfn_VAL1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46245">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS07G0563300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46245:SF3">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION REPRESSOR VAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25813">
        <property type="entry name" value="zf_VAL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TF-B3" evidence="10">
        <location>
            <begin position="314"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="CW-type" evidence="11">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP04043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="92081" checksum="F2048F838466ED2B" modified="2014-10-01" version="1">MGSKICMNEVCRLTTSPEWKQGWGLKSGGFATLCSSCGTAYENLVFCEKFHLDEDGWRECKICRKRIHCGCVASKMLHEFLDFGGVGCITCVKQMDTPSLRTVKILGDEIPNGTIGHRSFDSLLQLCNNVDVNGSKKMFKPHKVGTNASLGQKKGEGTALPFEQVNTSSPNFTPQSVGSSMFVKPEISRQNQGFKDMAESLAQPSVNFSLSNALSASGSALPISEGIVEGSEQNRVSTAQQGQRARQILPKPPKPGSSVGSENTKGMGSQTRIARPPAEGRGRSQLLPRYWPRITDQELQQISGDLKSTVVPLFEKVLSASDAGRIGRLVLPKACAEAYFPPINQSEGLPIRIQDVKGKEWTFQFRFWPNNNSRMYVLEGVTPCIQNMQLQAGDTVTFSRIDPGGQLVMGFRKSTTNVETQDPQPSGLPNGGSPGETSYLGASDNMLAISENGNNGGQIHEDSSQRNILIPEKKKARNIGLKNKRLLMHSDDAMELRVTWEEAQELLRPPTNSPTIIKIEDCEFEEYDEPPIFGKRTIFTVQPSGQQEQWAQCDNCSKWRRLPMHVLVPARWTCPDNAWVLNSTCSAPDDINPRELEALNIASKDFKRRRIVETKVAEDYEPSGLDALATAAVLGDNMGDLTEMSVGATTKHPRHRPGCSCIVCIQPPSGKGKHPPSCKCNVCLTVKRRFKTLMMRKKKRQSDREAELLQGKDQETPPLDMSEMEGAAEQALLLTNHSDAERSQNGSLMEAGESNKGQLDLNCHPSREEDMLAEAAAGINLATLIDAASIPLDVYMRQDGVASLSHHLLPSHAPGDGEGSLPEEGCSASANMGPEKKGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U943</accession>
    <name>A0A068U943_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00019508001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U943"/>
    <dbReference type="FunCoup" id="A0A068U943">
        <property type="interactions" value="2026"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U943"/>
    <dbReference type="Gramene" id="CDP04792">
        <property type="protein sequence ID" value="CDP04792"/>
        <property type="gene ID" value="GSCOC_T00019508001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U943"/>
    <dbReference type="OMA" id="HYAFKYA"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U943"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00315">
        <property type="entry name" value="Cyt_C5_DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="388" mass="44395" checksum="833284A757EF932D" modified="2014-10-01" version="1">MEFEGLREERGKKPWRVLEFYSGIGGMRYSLMKAGVNAVVVEAFDINDVANDVYQRNFGHRPYQGNIQSLSAADLDSYEAEVWLLSPPCQPYTRQGLQKGSSDARASSFLRILELIPQTSQPPLMLYVENVVGFETSDTHKRMVKMLEENNFILQEFILTPLQFGIPYSRPRYFCLAKRKPLAFKNPQFNNQLLWSPGPLYEQDDEKGSMVDQSHGIFDDSIKACRPIEDFLEDKVPRNKVHSDYCTLLANVSDLSEQTDKRNGCSRSSLNKYLVPLSLVERWGSAMDIVFPASRRCCCFTKSYYRFVKGTGSLLATNQEKTEDKKVPLEELGLRYFTPREVANLHSFPEDFQFPEHISLRQCYALLGNSLSVGVVAPQLRYLFTHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9V7</accession>
    <name>A0A068U9V7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter B family member 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00020229001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9V7"/>
    <dbReference type="FunCoup" id="A0A068U9V7">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9V7"/>
    <dbReference type="Gramene" id="CDP05251">
        <property type="protein sequence ID" value="CDP05251"/>
        <property type="gene ID" value="GSCOC_T00020229001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9V7"/>
    <dbReference type="OMA" id="YTKPFNE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9V7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18557">
        <property type="entry name" value="ABC_6TM_TAP_ABCB8_10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF7">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="127"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="487"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP05251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="79731" checksum="AA7A9B1605842AE9" modified="2014-10-01" version="1">MAIPAAASPLIHLMTAANYNKNIPRRRLRALTSGSDCHVLGEKLSVSPLSSSSLSCWRQQSGRSLSGRQFLKSVITSAYVSGPASVSSENSEFKVEEEEASEPAQPAYLVSWGLLWRLVSRHKLRLAASLLALVGCTTCTLAMPIYSGRFFEVLVGRRQEPLWQLLSKVGILYTLEPIFSVIFIVNMNSVWEKVMSSLRAQIFQRVLIQKVEFFDHYKVGELTSLLTSDLGSLKNIVSENVSRDRVFLAIVYVAGTICLLFALSPQLAPILGFLIIFVSTFIAVYKRTTVNVFKAHALAQASIADCVTETFSAIRTVRSFGGEKRQMSFFGRQVLEYESSGIKLGTFKSINESLTRIAVYVSLVTLYCLGGSKVKAGKMTVGTVASFIGYTFILTFAVQGLVNTFGDLRGAFAATDRINSVLSGAEIDEALAYGLNKDIKLMKMPDKEFGIFLVNGFESQTQSLDMPYTTSLKSASSVRSLAGSGDICLEDVHFSYPLRPDVEVLNGLNLCLRHGTVTALVGSSGAGKSTIVQLLARFYEPSRGRITVAGEDLRTFDKREWARVISIVNQEPILFSVSVGDNIAYGLPDDYVSKDDVIKAAKAANAHDFIISLPQGYDTLVGERGGLLSGGQRQRIAIARALLKNAPVLILDEATSALDTVSERLVQSALNRLMKGRTTLVIAHRLSTVQNANQIALCSNGKIAELGTHSELLSRRGQYASLVGTQRLAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9Y9</accession>
    <name>A0A068U9Y9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00020050001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9Y9"/>
    <dbReference type="FunCoup" id="A0A068U9Y9">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05112">
        <property type="protein sequence ID" value="CDP05112"/>
        <property type="gene ID" value="GSCOC_T00020050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9Y9"/>
    <dbReference type="OMA" id="EPNERIW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9Y9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002148">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g29760, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF373">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY, DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="580"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="672" mass="75579" checksum="850C793567C41874" modified="2014-10-01" version="1">MKSIGIPLHVSRQFSTACQKALLLPAATVPSEAASYSQVLDKWPDIRTLKKIHCRIILHLNLSSCISFGIKLMRAYAARGQTSITRQIFDRIPERNVVIFNVMIRSYVNNHLYHDALFMFKSMNSSNTNPDYYTFPCILKACSASMDLRVGLQVHTQVLKMNLDGNLYVGNGLIAMYGKCGSLTGARSVLDEMPRRDVVSWNSMVAGYAQNGGFNDALEVCREMQTFGLNPDAGTMASLLPAVTNTSSENVAFVEDMFMKVRRDELVPWNVMIAIYVNNSMPNKAVELYMEMEERRIEPDAITISSILPACGDLSAMMMGRRIHKYVERKRILPNLSVENALIDMHAKCGCLQEAKEVFDKMHFRDVVSWTSVISAYGKSGKGAKVVALFSEMQESITPDAIAFVSILSACSHAGLLEEGRHFYELMTKEYKIVPRLEHFACMIDLLGRAGRVREAYDFIKQMPLEPNETVWGAFLSACHVHKDMDIALEAADHLFQLAPKVSGYYVLLSNIYAKSGRWKEVASIRSIMKCRGIKKLPGISNVELNNQVHTFLAGGQSHPQSKEIYEELDALIGKMKDAGYVPETEDALHDVEDEDKENHLAVHSEKLAIVFAMINTKPGTLIRITKNLRVCRDCHIAAKLISKITERQIIIRDTNRFHHFENGFCSCGDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA92</accession>
    <name>A0A068UA92_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00020053001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA92"/>
    <dbReference type="STRING" id="49390.A0A068UA92"/>
    <dbReference type="Gramene" id="CDP05114">
        <property type="protein sequence ID" value="CDP05114"/>
        <property type="gene ID" value="GSCOC_T00020053001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA92"/>
    <dbReference type="OMA" id="LFCVSHG"/>
    <dbReference type="OrthoDB" id="77038at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA92"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF58">
        <property type="entry name" value="WRKY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="640" mass="67203" checksum="73FBE2A128AAEFBC" modified="2014-10-01" version="1">MDKAPVHCSANLAEVSTDLNKFVNVQSSDFARPVLGLDSYGVANSYFSRGSKRKWGMVDGSSLFLGLGHSSSSCTTMSPGREMEEDSSIHLGLSIDLQLGNHRANYANQLPYITAKAYEARRAEVDLELSLSTGPAESDVTTITQGSSPHKNKIEPPASVATVQLVDEGSTSSRWKCGPLVPPVQSLGTFALGDQLNSCNNQTPLTTNISSASPATPRNTVSCASGAIPQSQRRINVKTCRFEGCIRGARGASGLCIAHGGGRRCQRAGCQKGAEGRTVFCKAHGGGRRCQHLGCTKSAEGRTDFCIGHGGGRRCNHDGCTRAARGKSGLCIRHGGGKRCKMENCTKSAEGISGLCISHGGGRRCQYPTCAKGAQGSTVFCKAHGGGKRCTYLGCTKGAEGSTPLCKGHGGGKRCTFEGCTKSVHGGTLFCVSHGGGKRCSMAGCTKSARGRTNFCVRHGGGKRCKHEGCTKSAQGSTDFCKAHGGGKRCSWEQVGSEFGGQATVPCDKFARGKSGLCAAHTAQVQEKLVHGDGVLMVPILENRLFSKLERMKGVFAVSSGTDTTNRGAISVGMSSHGHKDACCRMPPQDNLDEFSLPEGRVHGGSLMAMLRGGTSFQTGNSTMHGDEVGRQKTYPISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAC3</accession>
    <name>A0A068UAC3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-carotene 3-hydroxylase</fullName>
            <ecNumber evidence="5">1.14.15.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020092001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.24" evidence="5"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAC3"/>
    <dbReference type="FunCoup" id="A0A068UAC3">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAC3"/>
    <dbReference type="Gramene" id="CDP05144">
        <property type="protein sequence ID" value="CDP05144"/>
        <property type="gene ID" value="GSCOC_T00020092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAC3"/>
    <dbReference type="OMA" id="TIYFRHS"/>
    <dbReference type="OrthoDB" id="9990796at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAC3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010291">
        <property type="term" value="F:beta-carotene 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016119">
        <property type="term" value="P:carotene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016123">
        <property type="term" value="P:xanthophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045019">
        <property type="entry name" value="BETA-OHASE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31899">
        <property type="entry name" value="BETA-CAROTENE 3-HYDROXYLASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31899:SF9">
        <property type="entry name" value="BETA-CAROTENE 3-HYDROXYLASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="154"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="310" mass="34723" checksum="F303818D24721B18" modified="2014-10-01" version="1">MAAGIAVAAGAQTVCFRVNSFLTRKPTSLVADSLTLSPLAQQFSTTRRHRRKPRLTVCFVLEDEELKAQLVTSEEEAREREKAMAKRISDARTAEKLARKRSERFTYLVAAVMSSFGITSMAVLAVYYRFVWQMEGGEVPYSEMFGTFALSVGAAVGMEFWARWAHKALWHASLWHMHESHHRPREGPFELNDVFAIINAVPAIALLSYGFFHKGLIPGLCFGAGLGITVFGMAYMFVHDGLVHKRFPVGPIANVPYFRRVAAAHQLHHSDKFNGVPFGLFLGPKELEKVGGLEELEKEINRRIKLRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB37</accession>
    <name>A0A068UB37_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020458001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Modulates plant growth and development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB37"/>
    <dbReference type="FunCoup" id="A0A068UB37">
        <property type="interactions" value="3655"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB37"/>
    <dbReference type="Gramene" id="CDP05419">
        <property type="protein sequence ID" value="CDP05419"/>
        <property type="gene ID" value="GSCOC_T00020458001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB37"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB37"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="446" mass="49988" checksum="9359ACC4E0551DB0" modified="2014-10-01" version="1">MCGLRKFNYPTKNPITTPHFGYISTNKPSAAAYISSFLFSLRSLLIQSAMADAHETDKNIEIWKIKKLIKALEAARGNGTSMISLIMPPRDQISRVTKMLGDEFGTASNIKSRVNRQSVLAAITSAQQRLKLYNKVPPNGLVLYTGTIVTDDGKEKKVTIDFEPFRPINASLYLCDNKFHTEALNELLESDDKFGFIVMDGNGTLFGTLSGNTREVLHKFSVDLPKKHGRGGQSALRFARLRMEKRHNYVRKTAELATQFYINPSTSQPNVSGLILAGSADFKTELSQSDMFDPRLQAKILNVVDVSYGGENGFNQAIELSSEILSNVKFIQEKRLIGKYFEEISQDTGKYVFGVDDTLKVLEMGAVETLIVWENLDVEDKLSLLEWFANEYKRFGCTLEFVTNKSQEGSQFCRGFGGIGGILRYQLDVRAFDELSDEGEVYDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBA3</accession>
    <name>A0A068UBA3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00020997001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBA3"/>
    <dbReference type="FunCoup" id="A0A068UBA3">
        <property type="interactions" value="1500"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBA3"/>
    <dbReference type="Gramene" id="CDP05731">
        <property type="protein sequence ID" value="CDP05731"/>
        <property type="gene ID" value="GSCOC_T00020997001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBA3"/>
    <dbReference type="OMA" id="SRFQGQI"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBA3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF42">
        <property type="entry name" value="DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="218"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="897"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="923" mass="101527" checksum="1C9992AD8E5A2A88" modified="2014-10-01" version="1">MGQIVKRKKKGRPSKADLAKRRSVGEDASAPERELRRSHRQRNVRYTFDFDDYLDDDELFEGFDDEEDERRREKKLKLLLKLQTSRETTTTESTPSETRRASHAPAASQSSSDLGGDGSYNKPSKKRKMSDSLARGRSRQGVNEEAEAEAEVDEEDENDDVDDDDNENVEDDEVVKGRGNADKPKGVEDSAPGTPTEAPSGLPLPEKKTLELILDKLQKKDIYGVYADPADPEELPDYHEVIEHPMDFATVRNKLGNGSYANLEQFESDVFLISSNAMQYNGPDTIYHKQARAIQELAKRKFQKMRLGIERSDELKSDQKTRLSSVVKKQIRKPISRTLQDPVGSDFSSGATLATNGDIQNGSSAAQVGGSERASSVDRLEVPPVIDNSIDKAEELLPGKRPLAKIERKQSLNDENRRATYNLSTQPVASFDSVFSTFDGESKQLVSVGLYADHSYARSLARFAATLGPVAWRIASKRIEQALPSGSKFGRGWVGEYEPLPTPVLMLENCTLTEPPFFTKIEQTVVTRKQEKMPTKPVSSRENIVTEPCVDKLVKAAPSYKDGLVKDSTVQRKSAFFGPTVIKPTACSSPSISLPAKEQAVRVLEGRSFFGSPANKTTFSASSGFQQQNSQPRNFTEPEKRFLKEVELNGPPSGSQTAADFVVERQILNSSDIPGSRSKDMVLKNKSLLPSGSFKQSNLNGVAVGGLPNGKVNNIDSNKKSSSASDLAKGATYFPHAQDQGLTDPVLLMKMLTEKAQNQHKSSNQSPVDSGPVLSPALPLRKEDSGNAAAAAARAWMSIGAGGFRPAGENTGLHKNQISADSLYNPARDLQSQVSRFRGDPPPYAMHLQPDKNNFPFHPFVPQPTRIGSDVQFHNQPMVYPQLVTADLSRFQVQSPWQPIRSPGRPASSVLVDSQQPDLALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC69</accession>
    <name>A0A068UC69_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00020167001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC69"/>
    <dbReference type="FunCoup" id="A0A068UC69">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC69"/>
    <dbReference type="Gramene" id="CDP05203">
        <property type="protein sequence ID" value="CDP05203"/>
        <property type="gene ID" value="GSCOC_T00020167001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC69"/>
    <dbReference type="OMA" id="MQKITVR"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC69"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22814">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22814:SF319">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="136" mass="15147" checksum="719D072B27B07514" modified="2014-10-01" version="1">MVEVRVPNLDCEGCAAKTRKAIFKLKGVEEVDVEMETQKITVRGFGLEEKRVLKAIRRAGKAAEPWPYPAGYSYFASFYKYPSHVVNHYYDTTKNVAAPSVYSFFHTPAVYSVAVASDEAVASLFSDENPHACAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCP3</accession>
    <name>A0A068UCP3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00021394001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCP3"/>
    <dbReference type="FunCoup" id="A0A068UCP3">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCP3"/>
    <dbReference type="Gramene" id="CDP06042">
        <property type="protein sequence ID" value="CDP06042"/>
        <property type="gene ID" value="GSCOC_T00021394001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCP3"/>
    <dbReference type="OMA" id="AYWNTRT"/>
    <dbReference type="PhylomeDB" id="A0A068UCP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001022">
        <property type="entry name" value="Probable LRR receptor-like serine/threonine-protein kinase At1g53420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000217">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase At1g53430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000004">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000044">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF81">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="665"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="977"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="985"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP06042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111630" checksum="C1358A3CDC5C80DA" modified="2014-10-01" version="1">MLLRGRLGFSVASAAAIIFIFWPVKLASGATLVPDEVDVLREIAKTLGKTDWNFGVDPCSGESNWRNATAPKEFANAVTCDCFFQNSTTCHVVSIVLKSQSLPGELPPELVKLPYLREFDVTRNYLSGSIPPIWGTMQLVNISLNSNRISGRIPKELGNISTLANLTLDFNQLSGTIPPELGNLSRLQKLTLTSNNWTGELPRTLADLTALKIFWIGDCNFTGSIPNFIENWKSIENLVIHGSGLKGPIPPGIASLTNLTDLRISDLSGNDTTFPNLRGATNMRTLVLRSCNIVGQLPDYLGSLTKLKVLDLSFNKIDGPIPRSLDALSNTVFIYLTGNNFTGTIPGWMLNTGEYVDLSYNNFALANSGSTRCQAGNLNLFASFSKNNKSSTFSCSQSFRCQQDWSSLHINCGGKGVKIGDTNYDDDTQPGGPSKLYQSGTNWAFSSTGHFADDHHNLDSYINSSDPGILGNEMQLYSDARLSPLSLTYYGFCLVNGNYTVKLHFAEIMFTDDRTYSSLGRRVFDIYMQGKLIQKDFNIENAAGGVNKPVVLNFTAVVTDSTLEIRFYWAGKGTTDIPQKGVYGPLISGISVDPDFPVPSDHGLSVGAIVGIVLAVLVIISVALAILWWKFGPQLRQTLQLDFKGLDLQTGSFALRQIKYATNNFDSANIIGKGGFGSVYKGILADGTVIAVKQLSSKSNQGNREFLNEIGMISALQHPNLVKLYGCCIEGNQLLVVYEYMENNSLARALFGPEEHQLELDWPTRRKICLGIARGLAFLHEESRLKIVHRDIKATNVLLDKELNPKISDFGLARLHEEDDTHISTRVAGTFGYMAPEYAMRGYLTDKADVYSFGVVLLEIVSGKSNTGFKPKEEECFNLLDWAHLLKEEMKLIELVDSRLGTDINEREIILTIEIALLCTSVSPAGRPSMSTVVSMMEGRVKDQKLIPDSSVLGAKVREISDEKYLLTTFNESQLQSTSSDRPLTASPASAPFTASSASASDLYPINPKSDFLDNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDZ8</accession>
    <name>A0A068UDZ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00023381001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDZ8"/>
    <dbReference type="FunCoup" id="A0A068UDZ8">
        <property type="interactions" value="1659"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDZ8"/>
    <dbReference type="Gramene" id="CDP06507">
        <property type="protein sequence ID" value="CDP06507"/>
        <property type="gene ID" value="GSCOC_T00023381001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDZ8"/>
    <dbReference type="OMA" id="CICIDFK"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDZ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044243">
        <property type="entry name" value="FLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47310">
        <property type="entry name" value="PROTEIN FLUORESCENT IN BLUE LIGHT, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47310:SF2">
        <property type="entry name" value="PROTEIN FLUORESCENT IN BLUE LIGHT, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="300" mass="33582" checksum="8B2CAB7E61E58FFD" modified="2014-10-01" version="1">MMMMRQGLVAWSPYPRSMCSPSSLQTTKAHRLQPTFLTVSARLQDGVAQHQITCKYDINIARQLLTISHKEMMSLRVPVMALIATDALMYFAPLEAIAETCEADNSILNMNMPLLLFVALIGATVGGLLARQRRGELQRLNEQLRQINAALRRQAKIESYAPNLSYAPVGGRIPESEVIVDPRKQELIACLKNGKNFLRNQDPEKAFAEFKSALELAQNLKDPIEEKKAARGLGASLQRQGKYREAIKYHSMVLAISQREGEESGNTEAYGAIADCYTELGDLERAAKFYDQYIARLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UED2</accession>
    <name>A0A068UED2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021333001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UED2"/>
    <dbReference type="Gramene" id="CDP05993">
        <property type="protein sequence ID" value="CDP05993"/>
        <property type="gene ID" value="GSCOC_T00021333001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UED2"/>
    <dbReference type="OMA" id="GICPVFK"/>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UED2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053031">
        <property type="entry name" value="Cuticle_assoc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396:SF10">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396">
        <property type="entry name" value="OS03G0264950 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP05993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="343" mass="39516" checksum="2C564ADA5E5F94BC" modified="2014-10-01" version="1">MLKQKVKMLRHCAFYSGLSLVKTWWLALLVSWSQHASETWFLFGSTHQSQAICLHFKGLCEVKMSDANNELSVDVNDLSEASTGEKRKREVKLRSKAWEHFTKLIKEDGTYEKCQCNHCNKLFTCSSRSGTTHLLRHITEGICPVYNRGKKDRPPTILNYMRGSSEPRNNMTSWKFNQGLDQAGHESVDMRDELLSAGLEDLERQTREVLEDDYVGQPSPPVSVKYPQQSALKRQSRGDSWMTELRACVSKLVDLTTERMPNGSSIKSSLAVTAPDYSIAAALRCLNEMEDIPQSSEMYLDAFELLKDDGERECFICLPAEPRRRWLQRMLHRRYPLRYNCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG68</accession>
    <name>A0A068UG68_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dof zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00023536001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG68"/>
    <dbReference type="STRING" id="49390.A0A068UG68"/>
    <dbReference type="Gramene" id="CDP06623">
        <property type="protein sequence ID" value="CDP06623"/>
        <property type="gene ID" value="GSCOC_T00023536001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG68"/>
    <dbReference type="OMA" id="ANIHMPE"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG68"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992:SF191">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="11">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP06623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="355" mass="37746" checksum="ACEDCDAE571B2906" modified="2014-10-01" version="1">MVFSSIPAYLDPANWQQPSNHQAGNSSGNHPPLQPPAQQQPVPSFPPAQPHAGGGPGAVSIRPGSMAERARLANIPLPEAALKCPRCESSNTKFCYFNNYSLTQPRHFCKTCRRYWTRGGALRNVPVGGGCRRNKRTKATSSKSPVSSADRQTTSSSTGTVSSNSTPSANVLGLTPQIPPMRFLSPLSQLSDHYSPAGDISLNYGANNSAPLLGTSEMNFHIYPNNLLSCGLGGGAASLLPGGGIEQWRLQQAQQFPFLGGLEASPPGLYSQLQASSVEPSGFVGETSRHHVRPKLSSSILTQQASVKMEDNHQELNLSTQLMGIPGNHDQWNGTAAAWTTDLASFSSSSTTNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGB0</accession>
    <name>A0A068UGB0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00024362001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739109">
        <property type="protein sequence ID" value="CDP07194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGB0"/>
    <dbReference type="Gramene" id="CDP07194">
        <property type="protein sequence ID" value="CDP07194"/>
        <property type="gene ID" value="GSCOC_T00024362001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGB0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="84" mass="9956" checksum="0C54ABE2030F4132" modified="2014-10-01" version="1">MGKFAIEFQLLTWCFISPPSWIDRVLKILRLRRSLCFLLLLRRFLPFFSVQDKIEVTRWSSSYKLKGSYGSGFIFLLSQRFAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGG7</accession>
    <name>A0A068UGG7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024625001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGG7"/>
    <dbReference type="FunCoup" id="A0A068UGG7">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGG7"/>
    <dbReference type="Gramene" id="CDP07382">
        <property type="protein sequence ID" value="CDP07382"/>
        <property type="gene ID" value="GSCOC_T00024625001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGG7"/>
    <dbReference type="OMA" id="DDCIVQW"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGG7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF242">
        <property type="entry name" value="OS06G0633500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="377" mass="41807" checksum="352DD37BCD4F49AA" modified="2014-10-01" version="1">MAETPSDQTQTQAETQVPAGSDPNPSQYWCYHCDKRVSIETLADLPDVICHECKNGFVESIGPPAAPAAASDPMDDPSFGNQFLQVLRLIAQAARDEDAPPPPPSEHADPSDDDYLRIELDGWDNDDDEDDENEIEVRNEDVEENRERVDQNRDQSDDDDDDEEEVDDENEENETREETDEDDLRRRRRDVLRLRLRDFAARAANRRNRILDWAEILMGLEDHSIELRLAVPEGEGYIGNPGDYVDAAGYEALLQNLAETDSGGRRGAPPASKASVEALETTEIKSELEALACAVCKDIVGVGEMVKKLPCGHGYHGDCIIPWLESRNSCPVCRYELPTDDAEYEEERKKRAAAAAAPSSSSGGSGGISGDYETEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHQ0</accession>
    <name>A0A068UHQ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00026800001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHQ0"/>
    <dbReference type="STRING" id="49390.A0A068UHQ0"/>
    <dbReference type="Gramene" id="CDP08085">
        <property type="protein sequence ID" value="CDP08085"/>
        <property type="gene ID" value="GSCOC_T00026800001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHQ0"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHQ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000004">
        <property type="entry name" value="Berberine bridge enzyme-like 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657982" description="FAD-binding PCMH-type domain-containing protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP08085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="481" mass="54238" checksum="B0B84827A0179845" modified="2014-10-01" version="1">METTPSTKISYIFLCSLVLIFSMPWSTRAQIHDRFLQCLHSRNNDSISQVIYTPTNSSYNSVLQSSIQNIRFISPMERKPLVIVTPLNDFHVQSAVICAKSNGFQIRVRSGGHDYEGLSSISYYHQPFVIVDMRNLSGISIDTESKTAWIGVGVQGTLTRKYGLAADNVIDAKIVNADGAILDRKSMGEDLFWAIRGGGGASFGVILKYRLQLVSVPSIVTVFTVNRNLEQNATKLVHRWQQIGYQLDRDLFIRLLITQARSGQGGNLTVQVGFQSLYLGTVAKLLPLMQESFPELGLRREDCTELSWIESALYFSGLPSGSTVNDLPISEVALEGLWKRLFEEGAEAGMLILSPSGGRMFEISDSETPYPHRAGNIYQIQHISSWTEENNANSQRYIDWVRRVYKYMTPFVTKSPRAAYLNYRDLDLGANREGNTSFAQASIWGMKYFKNNFYRLAHVKQEVDPSNFFRYEQSVPPFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHQ2</accession>
    <name>A0A068UHQ2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00025192001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHQ2"/>
    <dbReference type="STRING" id="49390.A0A068UHQ2"/>
    <dbReference type="Gramene" id="CDP07802">
        <property type="protein sequence ID" value="CDP07802"/>
        <property type="gene ID" value="GSCOC_T00025192001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHQ2"/>
    <dbReference type="PhylomeDB" id="A0A068UHQ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654927" evidence="3">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="165" mass="18750" checksum="5426247A7C0E1A3B" modified="2014-10-01" version="1">MECLGMWNRMTVVLLIGCVMNAEVSAVAYCLYELSSTIHIIQLGSYVFDRVRVSNELGSGRSRTAKFSIMVVGTFSTLFGLVFALVLFLQRKQFPAIFSTDPEVKQLVDRGANKPNQPEHPSVQIYLSILMSLKFYSNMTLLFTEPNLNELFTEFENYAVQVWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJA7</accession>
    <name>A0A068UJA7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain 3-oxoacyl-CoA synthase</fullName>
            <ecNumber evidence="4">2.3.1.199</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00027645001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="4"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJA7"/>
    <dbReference type="FunCoup" id="A0A068UJA7">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJA7"/>
    <dbReference type="Gramene" id="CDP08625">
        <property type="protein sequence ID" value="CDP08625"/>
        <property type="gene ID" value="GSCOC_T00027645001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJA7"/>
    <dbReference type="OMA" id="WAGSIDQ"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJA7"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657730" description="very-long-chain 3-oxoacyl-CoA synthase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="13">
        <location>
            <begin position="57"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="14">
        <location>
            <begin position="365"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="511"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP08625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="643" mass="71571" checksum="D2E84AC3EE5E1089" modified="2014-10-01" version="1">MFLLILPLFLATLIQTADLISISDLHQVVVAEAVDVNDSRVAGLTCSVVLMLLLGLYLATRPRPIYLVDFACYKPEDQRKMSVDSFLKMTEDNGAFGDDSLQFQRRVSVRSGLGDDTYLPRGITSSPPNLCMEEARAEAEAVMFGALDSLFAKTGVRPQDIGVLIVNCSLFNPTPSLSSMIVNHYRLRANIKSYNLGGMGCSAGLISIDLAKHLLLKGNPNTYALVVSTENITLNWYFGNDRSMLLCNCIFRMGGAAVLLSNRSMDRSRSKYQLVHTVRTHKGADDNSYNCVYQREDEKGTVGVSLARELMVVAGDALKTNITTLGPLVLPLSEQLMFFLTLVKRTVLRARRVKPYIPDFKLAFEHFCIHAGGRAVLDELQKNLNLSDWHMEPSRMTLHRFGNTSSSSLWYELAYTEAKGRVSKGHRVWQIAFGSGFKCNSAVWRALRPISSVTAAGDDDDCKANPWADCIHRYPVKILGRNRQGPVERRQNNVGVGGQVAVLAAFQSKVQQQQKLKPPSSSSPGVRLKGPSSNEKQGNQQDKAAKQEAKKGGGEDRRQLSGSDVLWALQRATAEKAKKHQQQRQKRCNANQEEEDEMRRAVEVDDDRSNTNAGPRWLCIQSDWGFRLEALEKRLEELLLADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJV7</accession>
    <name>A0A068UJV7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RPM1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00025419001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJV7"/>
    <dbReference type="Gramene" id="CDP07913">
        <property type="protein sequence ID" value="CDP07913"/>
        <property type="gene ID" value="GSCOC_T00025419001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJV7"/>
    <dbReference type="OMA" id="SEDCGMN"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJV7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="177"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="435"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="551"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="105973" checksum="69CFE44FEBED0E07" modified="2014-10-01" version="1">MAESVVGFLIKQLSTLLSQEITLLGGLKSDVQFIKDELGSIKTFLKEAEAKEDNDSQLQEWLKQVREVAYDTEDVLDDFTFRFARRYKDGFCGKVGKIYNSIKNLKARHQISLEIKDIKGRVGEISARHQRYQSLYGTQERGFSTSRQVNADFDIRAQSLFIEEARLVGIDKPKAELISKILDDHSQLKVVSVKGMGGLGKTTLVKKVYDDAAVKKQFQSHAWITVSQNFQFSDIIKNLIQQLYNEIRQPVPPEVESMDDIMQSEFVKDFLRERRYILVLDDVWSIDAWEAIKCVLPDCNTASRVALTTRIADVASASCLGSLNFVYKMEPLSDKESWTLFCNRTFQSNDCPPNLEEVAKKILKKCEGLPLAIVAIGGVLALKDKENTDEWEMILHGFGGEADGSGKLDRIKRVLLLSYNDLPHYLKSCLLYLSIYPEDYLIEVDDILLKWIALGFVEEKEGITSTDIAVRCMKELINRSIIQVKSKLNDGRLDACSLHDFVREIIVSKSKEQSFTTVATRYYARWPEKFRHLAIHNFTDNPQEFSGLKCLRSVAIFGYEDPLTTTFLSEFLHGDPKLLKVLDLHGAELDNIPKQVFKLFHLRYLNLRGTGVKIIPKSIGKLQNLEVIDLRGTNVTELPAEILNLRKLRSLLLGGYGDYSNEYAIWGCKCPLGIGKLICLEDLLRIEADSDKIVREIGKLMQLRRLAITKLRREDGKELLSSLLRLTNLRQLSISCIEEDETLDLQHSISPKLEFLTFLRLKGRLERVPQWVTSLQSLRILRLVNSRLREDENVIGSLGHLPNLISLSLYGAYEGETICFKVGGFQKLQRLQLGQLTRLKWVRVEEESMPSLRNLRLGNCKLMQELPSGIQNLTRLESLAFYEMSNELMHKVQNLDKRSEDYQTISHIPEVFIGHWIDGQWEWTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL31</accession>
    <name>A0A068UL31_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription factor DIVARICATA-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00028370001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL31"/>
    <dbReference type="FunCoup" id="A0A068UL31">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL31"/>
    <dbReference type="Gramene" id="CDP09156">
        <property type="protein sequence ID" value="CDP09156"/>
        <property type="gene ID" value="GSCOC_T00028370001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL31"/>
    <dbReference type="OMA" id="AQHYPYG"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL31"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048262">
        <property type="term" value="P:determination of dorsal/ventral asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000009">
        <property type="entry name" value="transcription factor MYB1R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000154">
        <property type="entry name" value="Transcription factor SRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042:SF41">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="124"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP09156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32050" checksum="2C69AAAD7DF787A3" modified="2014-10-01" version="1">MEILPPASYLSNSGWLVEESKSTKWTPAENKAFENALAVFDKDTPDRWQKVAAVVPGKTVMDVIRQYKELVEDVSNIEAGLIPIPGYGTSPFTLEWGSGHNFDGYKQSFIATGKRSSATRPSEQERKKGVPWTEEEHKLFLMGLKKYGKGDWRNISRNFVITRTPTQVASHAQKYFIRQLSGGKDKRRASIHDITTVNLSDNQIPSPDRKKSSSPDTSNWNQGNSNGAVMNFNMGHGNIFMPPHGVNSCDLKMQGQDLQRGGMHNSYVGSQNMVFQMQSTHQYPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMR4</accession>
    <name>A0A068UMR4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00030150001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMR4"/>
    <dbReference type="FunCoup" id="A0A068UMR4">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMR4"/>
    <dbReference type="Gramene" id="CDP09711">
        <property type="protein sequence ID" value="CDP09711"/>
        <property type="gene ID" value="GSCOC_T00030150001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMR4"/>
    <dbReference type="OMA" id="AFRQMEC"/>
    <dbReference type="PhylomeDB" id="A0A068UMR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF56">
        <property type="entry name" value="PGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="8">
        <location>
            <begin position="101"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP09711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="254" mass="27805" checksum="9AC9B5BB78CE2C24" modified="2014-10-01" version="1">MQLYFNFSKIPLFNVVRLLINKVKINEKNLEGLTCLDTFTGLATAGDENIAKDLRGAGAKTSSALPPVDTLADVLSSKESLTRKAFRQMECDVGLDGLSSEMRNALLVVAVLIATATYQAVLSPPGGISSGESTGKVQMGEAYFYVFITLNTVAFAASLGIIFSLLPKSRYNLLLFIPLLTLLMSYAFSITIIAPHSRSLQMHAFYPVMIGFGLTMLIMRCKFPEFLGQAPNRYKRDQMEGDEIRGACAHVNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNF2</accession>
    <name>A0A068UNF2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00030202001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:19057"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:131871"/>
            <dbReference type="ChEBI" id="CHEBI:134019"/>
            <dbReference type="EC" id="1.11.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNF2"/>
    <dbReference type="FunCoup" id="A0A068UNF2">
        <property type="interactions" value="1479"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNF2"/>
    <dbReference type="Gramene" id="CDP09749">
        <property type="protein sequence ID" value="CDP09749"/>
        <property type="gene ID" value="GSCOC_T00030202001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNF2"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNF2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047066">
        <property type="term" value="F:phospholipid-hydroperoxide glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF118">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE 6, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP09749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="18872" checksum="9E1A8E5EBA47BEE6" modified="2014-10-01" version="1">MATQSSAPQSVHDFTVKDARGNDVDLSQYKGKVLLIVNVASQCGLTNKNYTELTKLYEQYKDQGLEILAFPCNQFGSQEPGTNEEIQQFACTRFKAEYPIFDKVDVNGSNAAPLYKFLKSSKGGLFGDSIKWNFSKFLVDKEGHVVDRYAPTTSPLSIEEDVKKLLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP42</accession>
    <name>A0A068UP42_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00030798001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP42"/>
    <dbReference type="FunCoup" id="A0A068UP42">
        <property type="interactions" value="3049"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UP42"/>
    <dbReference type="Gramene" id="CDP10171">
        <property type="protein sequence ID" value="CDP10171"/>
        <property type="gene ID" value="GSCOC_T00030798001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP42"/>
    <dbReference type="OMA" id="FRLKSAC"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UP42"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000016">
        <property type="entry name" value="Carbon catabolite repressor protein 4 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="20">
        <location>
            <begin position="255"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="607" mass="67430" checksum="07AD26965CDC4A11" modified="2014-10-01" version="1">MLSVLRVHLPSDIPIVGCELTPYVLVKRPDKSVITEDVPESTPLDGYFLRYKWYRIQSDRKVAICSVHPSEQATLQCLGCVKAKIPISKSYHCSPKCFSDAWQHHRVLHERAASAVNENGNEEEEIFGRFNGSGSGVINTNLTGTQANSSLANGATALYPAAVTQRGGETWFEVGRFKTYTPTADDIGHVLKFECVVVDAESKQPVGHPSTLHTSRVIPAPSPTPRRLIPVSGVEMPGHLDVDGRVSSSGTFTVLSYNILSDSYAANDLYSYCPSWALSWAYRRQNLLREIVGYRADIVCLQEVQCDHFEEFFAPELDKHGYQALYKRKTAEVFNGNIYSNDGCATFFRRDRFSHVKKYEVEFNKAAQSLTDALVPSTQKKTALGRLIKDNIALIVVLEAKFSNQGIDNPGKRQLVCVANTHVNVQQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNSVPGSAPHALLAMGKVDPMHSDLAVDPLGILRPATKLTHQLPLVSAYSSFGRAAGIGFEQQRRRLDLTTNEPLFTNCTRDFIGTHDYIFYSGMLKVNSDSLTVESLLELLDEDGLRKDTALPSPEWSSDHIALLAEFRCKPRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPC6</accession>
    <name>A0A068UPC6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00028864001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPC6"/>
    <dbReference type="FunCoup" id="A0A068UPC6">
        <property type="interactions" value="1228"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPC6"/>
    <dbReference type="Gramene" id="CDP09483">
        <property type="protein sequence ID" value="CDP09483"/>
        <property type="gene ID" value="GSCOC_T00028864001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPC6"/>
    <dbReference type="OMA" id="KEYSTHE"/>
    <dbReference type="OrthoDB" id="1907298at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPC6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053284">
        <property type="entry name" value="RGS1-HXK1_interactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34554:SF1">
        <property type="entry name" value="ALANINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34554">
        <property type="entry name" value="RGS1-HXK1-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="272" mass="30129" checksum="E9A0A9C9D533E3F7" modified="2014-10-01" version="1">MTTTADGGASSPEKSNSAPPQGIVPAFNDDIVEKLKTLEETASPWIDYALKQAQAAQKTIGHHLQDAIEVTKSRLDRIRTTSSAHFNQTLDSLQDAKSDFNAYEDLAIGKIREGFNLAAANPFIAAGSIFAVGLLGLKTPRRILYYKLRRLFASEQVLLSKADAKVKELRQSFEVLKAEAEKLEKAALQAEEEMTRGRTKLRQAGKQIQSVVRSAYKIERQAVGLKDVLRDLPSIEASRFRSQVSNLAKEAKKERRVLNKEVTKISNYGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPX4</accession>
    <name>A0A068UPX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031230001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPX4"/>
    <dbReference type="STRING" id="49390.A0A068UPX4"/>
    <dbReference type="Gramene" id="CDP10486">
        <property type="protein sequence ID" value="CDP10486"/>
        <property type="gene ID" value="GSCOC_T00031230001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPX4"/>
    <dbReference type="PhylomeDB" id="A0A068UPX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050355">
        <property type="term" value="F:inorganic triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07374">
        <property type="entry name" value="CYTH-like_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948">
        <property type="entry name" value="OS08G0299200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948:SF2">
        <property type="entry name" value="TRIPHOSPHATE TUNNEL METALLOENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="231" mass="26364" checksum="A92BE7FB245AC2B5" modified="2014-10-01" version="1">MLRRKATKIEVKLDDKEELEESRTSNLWAGHILRRITTSFAKQMEVEVKLRLPDSAAHRKVLSLLSPFHTKTHHQRNSFYDGAAGELSSRRAVLRLRFYENSQPLKCFICLKAKAVIVDGVSRVEEDEEEVDFEVGLQCLEDATKLVDVDSRVARRAREEFGVKAGFVGLGGFRNVRNVYERMRLSTHIRRCQSLRLFGLESCLSNYCHVGGCLLIPVKKQKVDAAINQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URT1</accession>
    <name>A0A068URT1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00033311001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URT1"/>
    <dbReference type="STRING" id="49390.A0A068URT1"/>
    <dbReference type="Gramene" id="CDP11210">
        <property type="protein sequence ID" value="CDP11210"/>
        <property type="gene ID" value="GSCOC_T00033311001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URT1"/>
    <dbReference type="OMA" id="FLATIDM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URT1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="142" mass="15840" checksum="31EF55167C07FB14" modified="2014-10-01" version="1">MILFILILITCLFLATIDMFLEFNTWLGSDFGTAKFLQKDSSNWTPLAGTLGYIAPEFAHTMRVTEKCDVYSFGVLTLKIIKGKHPGELVGHLMSSTAGDRELKDLLDQRLSHPSQEIEKILVFVLKIAVACLHVNLGQLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URX5</accession>
    <name>A0A068URX5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033052001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URX5"/>
    <dbReference type="Gramene" id="CDP11057">
        <property type="protein sequence ID" value="CDP11057"/>
        <property type="gene ID" value="GSCOC_T00033052001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URX5"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URX5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="101" mass="11800" checksum="8E12929119E74F6D" modified="2014-10-01" version="1">MSCRYRSLCAYNGDDDLFSSDLSEEQLRQRLGHMSHTPCQCHYNIRVLQIIFSKADECVPEYVDKKAFVERLCRVMNGAEKVEIEWGNHALSNRGWDDPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USB0</accession>
    <name>A0A068USB0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00031270001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USB0"/>
    <dbReference type="FunCoup" id="A0A068USB0">
        <property type="interactions" value="1340"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP10518">
        <property type="protein sequence ID" value="CDP10518"/>
        <property type="gene ID" value="GSCOC_T00031270001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USB0"/>
    <dbReference type="OMA" id="LNYHWWW"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USB0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007353170" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="24"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="656" mass="74319" checksum="662C2808382CDC02" modified="2014-10-01" version="1">MESSRKIKIWVLFICMISQLGHGFYLPGSYPHKYGIGGFLNVKVNSLTSIETEMPFSYYSLPFCHPKEGVKDSAENLGELLMGDRIENSPYRFKMYNNETEVFLCQTKPLSGEEFKLLKKRIDEMYQVNLILDNLPAIRYTRKEGYFLRWTGYPVGIKVQDVYYVFNHLKFTVLVHKYEDTNVARVMGTGDGAEVIPGGNAGSDAPGYMVVGFEVVPCSFQHNADSLKNLNIYDKYPSPVKCDPSIVSMPIKENEPVAFTYEVSFVERDIKWPSRWDAYLKMEGAKVHWFSILNSLMVITFLAGIVFVIFLRTVKRDLTRYEELDKEAQAQMNEELSGWKLVVGDVFRAPSNPALLCVMVGDGIQILGMAVVTILFAALGFMSPASRGTLITGMLFFYMILGIAAGYVAVRMWRTIFCGDHKGWVSVSWKVSCFFPGIAFLILTVLNFLLWGSHSTGAIPFSLFVILILLWFCISVPLTLVGGYFGAKAPHIEYPVRTNQIPREIPPQKYPSWLLVLGAGTLPFGTLFIELFFIMSSLWMGRVYYVFGFLFIVLILLVVVCAEVSLVLTYMHLCVEDWKWWWKSFFASGSVAIYIFLYSVNYLIFDLKSLSGPVSATLYLGYSLFMVTAIMLATGAVGFLSSFWFVHYLFSSVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USL4</accession>
    <name>A0A068USL4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00033442001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USL4"/>
    <dbReference type="FunCoup" id="A0A068USL4">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USL4"/>
    <dbReference type="Gramene" id="CDP11292">
        <property type="protein sequence ID" value="CDP11292"/>
        <property type="gene ID" value="GSCOC_T00033442001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USL4"/>
    <dbReference type="OMA" id="WEFASFE"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USL4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35657" checksum="72EE448EDC34AA97" modified="2014-10-01" version="1">MVYSRFSSKLLGSKDSSSQNKGAFDRIRDRDGNRKGGSGESWWKVNCYSKYPLKFIIPNKVGPSQTDAVWIYTITYGGGIVSGDSIMCDISVGGGCTTVLTTQASKKVYKSVESKCSKQVLEARIGSDALLAVIPDPVTCFSTAKYSQTQVFKVFPSSSLLIVDWITSGRYGRGEKWDFELYKSTNNIFLEADEPLFLDTILLEQRRYSSIAERMQYYQVIAMVILLGPKLKFIQDQIQENVKNLMSRQFCIPSGSSGRYGDINDNPFLTRPSFLASCSVFGQKGRGVVVRIAAMTTESVYSFLQCQLSGLDSLLGVAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UST5</accession>
    <name>A0A068UST5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033444001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UST5"/>
    <dbReference type="STRING" id="49390.A0A068UST5"/>
    <dbReference type="Gramene" id="CDP11294">
        <property type="protein sequence ID" value="CDP11294"/>
        <property type="gene ID" value="GSCOC_T00033444001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UST5"/>
    <dbReference type="OMA" id="CEYSTLV"/>
    <dbReference type="OrthoDB" id="1923451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UST5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052451">
        <property type="entry name" value="Ser/Thr_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008:SF14">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="78" mass="9060" checksum="86F2AF5670312A28" modified="2014-10-01" version="1">MPNGSLEKWLYSHNYFLDLMQRLDILIDVACALQHLHCEYSTLVIHCDLKPSNVLLDQDMVAHLSDFSLSHTWLSCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUN7</accession>
    <name>A0A068UUN7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00035325001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUN7"/>
    <dbReference type="FunCoup" id="A0A068UUN7">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUN7"/>
    <dbReference type="Gramene" id="CDP11984">
        <property type="protein sequence ID" value="CDP11984"/>
        <property type="gene ID" value="GSCOC_T00035325001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUN7"/>
    <dbReference type="OMA" id="EVFGAMF"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUN7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF14">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="399" mass="45341" checksum="93E87481A8980614" modified="2014-10-01" version="1">MVKETEYYDVLGVGPSASEQEIRKAYYLKARQVHPDKNPNDPQAAERFQARAFSNLIIYLQELGEAYQILSDPVQRDAYDHHGKNCVSRETMLDPTAVFALLFGSELFEDYIGHLSVASMASFELAGENDNSEQVHNRLKAMKTVQREREEKLARTLKDLLYQYVRGDKEGFLRHAESEADRLSRAAFGADILDTIGYVYTRQAAQELGKKAIYLGMPFVAEWFRHKGHFWKSQITAAKGAFQLLQLQEDVRRQFKMDGSGPENDIESHLKHNKSVLMNSIWKLNVVDIEVTLLHVCQMVLQETNVRKEELKTRAVALKILGKIFQNAKHKQTGGTSKNKIASSINVDDSSSESSDDEDSPRALNYRTPLLTQGIGRLFRCLCNPAFDVDDEEIVYKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWC9</accession>
    <name>A0A068UWC9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00036238001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWC9"/>
    <dbReference type="STRING" id="49390.A0A068UWC9"/>
    <dbReference type="Gramene" id="CDP12579">
        <property type="protein sequence ID" value="CDP12579"/>
        <property type="gene ID" value="GSCOC_T00036238001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWC9"/>
    <dbReference type="OMA" id="FTYAPAF"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWC9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF11">
        <property type="entry name" value="DIHYDROCERAMIDE FATTY ACYL 2-HYDROXYLASE FAH2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="16">
        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="236" mass="27268" checksum="441BA9723F6BA7EF" modified="2014-10-01" version="1">MVAQGFTVDLNKPLVFQVGHLGEDYEEWVHQPIVCKESPRFFENDLLEFLTLNTWWVIPLVWLPVVCWFVKSSVNMGVSSNQLAATIAAGIFIWTLLEYTLHRFLFHIKTKTYWGNTIHYLLHGCHHKHPMDGYRLVFPPAATAILLVPFWNLIKLLTPTLYAPALLGGGLLGYVMYDCTHYYLHHGKPLQGVSSKMKRYHMNHHFRIQDKGFGITSTFWDRVFGTLPPKSGKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWJ1</accession>
    <name>A0A068UWJ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036366001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWJ1"/>
    <dbReference type="Gramene" id="CDP12657">
        <property type="protein sequence ID" value="CDP12657"/>
        <property type="gene ID" value="GSCOC_T00036366001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWJ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16411" checksum="3C30F5DD7D54B762" modified="2014-10-01" version="1">MLHLCRSWSHRLMSSSPHKLKGNSPMLCSSTSNYCQSESGANDLEVCLKYYHNRTSAQMARGKTNDYGGSSAIAKWEYEIKCYYVQLLQEHKEVGNLSKNNINGCVFEDMRNRLNMRFNHKSYDYDQVKRKYCSFMRVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWL7</accession>
    <name>A0A068UWL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036354001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWL7"/>
    <dbReference type="STRING" id="49390.A0A068UWL7"/>
    <dbReference type="Gramene" id="CDP12649">
        <property type="protein sequence ID" value="CDP12649"/>
        <property type="gene ID" value="GSCOC_T00036354001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWL7"/>
    <dbReference type="OrthoDB" id="1750420at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="87" mass="9296" checksum="DBE7B18A7F5B7411" modified="2014-10-01" version="1">MSPSGATQASAKELIDSIVEIVVRIFENHVIVGELLETKAAQQVDLNTPKSIVGDSKWNPDPKASHDTSGYCIGFSLTVLQVGLLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY15</accession>
    <name>A0A068UY15_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00038187001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY15"/>
    <dbReference type="FunCoup" id="A0A068UY15">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UY15"/>
    <dbReference type="Gramene" id="CDP13296">
        <property type="protein sequence ID" value="CDP13296"/>
        <property type="gene ID" value="GSCOC_T00038187001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY15"/>
    <dbReference type="OMA" id="SKNAPYK"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY15"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12203">
        <property type="entry name" value="GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000162">
        <property type="entry name" value="trihelix transcription factor GT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058943">
        <property type="entry name" value="GT-1/4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654">
        <property type="entry name" value="FI21293P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654:SF84">
        <property type="entry name" value="SI:DKEY-66I24.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26214">
        <property type="entry name" value="Ubiquitin_GT-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="402" mass="45606" checksum="6855E13EB7A96070" modified="2014-10-01" version="1">MYVSEQPPRAIDFYKEEDNPEAATGDMIIEVSTANNHLPPPQHRQVLGVGGGGDTTSSGGEDNTNTTHPLSSSSDLKAPKKRAETWVQEETRALISLRREIDSLFNTSKSNKHLWDQISLKMREKGFDRSPTMCTDKWRNLLKEFKKVKQNGDRNGSAKMSYYKEIEEILRERSKNSSSYKSPPPTSSNKVDSFMQFSDKGIDDTSITFETVEGDGRQPLNLERRLDHDGHPLAITATEAVAASEVSPWNWRENPGNGHQNASYEGRVISVKWGDYTKRIGIDGTPDGIKEAIKATFRLRTKRAFWLEDDNNIVRTLDRDMPLGNYTLHVDEGSLTIKFCLYEEADDLPVHTEDKTFYSEDDFRDFLSRRGWTCLREYDGYRNIDSLDDLCPGAAYRGVNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYG1</accession>
    <name>A0A068UYG1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00038417001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYG1"/>
    <dbReference type="STRING" id="49390.A0A068UYG1"/>
    <dbReference type="Gramene" id="CDP13461">
        <property type="protein sequence ID" value="CDP13461"/>
        <property type="gene ID" value="GSCOC_T00038417001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYG1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF148">
        <property type="entry name" value="CYTOCHROME P450 72A15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="138" mass="15560" checksum="6637C33C98BADE43" modified="2014-10-01" version="1">MRIVACELYYTRRAELIRLILSDKNGHLQKPPQNPLVDILTLGVSTLEGEKWTTCRRVINPAFHNEKIQAIHASSSYLTCIDGWKKSVPSDGSSEIDINPEVQSHFADVIARTAFGRSYREGKKIIELRGSERTSCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZP9</accession>
    <name>A0A068UZP9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00037904001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZP9"/>
    <dbReference type="Gramene" id="CDP13108">
        <property type="protein sequence ID" value="CDP13108"/>
        <property type="gene ID" value="GSCOC_T00037904001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZP9"/>
    <dbReference type="OMA" id="QTEEVAW"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000057">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1553">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47542" checksum="C6FF2B406014CA5E" modified="2014-10-01" version="1">METHRAHCLILPYPVQGHINPMLQFAKRLQHEGVKVTFATTKFLFETVDEVSASISVETISDGYDEGANGIVQKIYLPRFQKVGSETLTKLVLKLQDSGRPIDCIIYDAFLPWCLDVAKDLGVRAGVFFTQSCVVNNIYYHVHKGLLKLPLEATEVDIPGLPPLLASDLPSFVSNPGPYPATSQLVVHDQMEKIEEADWIFFNTFYRLEEKVIHWMAKILPVKTIGPTIPSVYLEKRLEDDKQYGLNLFKPMTNACMSWLNERSISSVVYVSFGSLAKLEVKQMEELAWGLRASSYHFLWVLDVLAHKSIGCFITHCGWNSTLEALSLGVPMIGMPQWTDQSTNAKFVKDIWKMGIKAQPDENGIVRRDVIGQCISIVMEGEIGQEIRKNAKKWKDLARQALEEGGSSDENTKDFVSKLIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0W5</accession>
    <name>A0A068V0W5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACT domain-containing protein ACR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein ACT DOMAIN REPEATS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00038520001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds amino acids.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0W5"/>
    <dbReference type="FunCoup" id="A0A068V0W5">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13538">
        <property type="protein sequence ID" value="CDP13538"/>
        <property type="gene ID" value="GSCOC_T00038520001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0W5"/>
    <dbReference type="OMA" id="GRMDVCC"/>
    <dbReference type="OrthoDB" id="2019938at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0W5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04925">
        <property type="entry name" value="ACT_ACR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04897">
        <property type="entry name" value="ACT_ACR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040217">
        <property type="entry name" value="ACR1-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096:SF50">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24931">
        <property type="entry name" value="ACT_ACR9_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="133"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="382"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="494" mass="54952" checksum="FC24322708D8D9E2" modified="2014-10-01" version="1">MNTASWPYFDPDFDGLSERVYGPVCRVTIDNESSDECTVLKIDSVNKQGLLLEVVQALTDMNLTILKSYISSDAGWLMDVFHVKDGSGNKVTDQNVINYIQKAIGANKEAMAKARARNTKFLESKTSAHEPTAIEMRGKDRPGLFSEISAALADLHINVVEAHAWSHNARLACVAYISDQSTSSPIDDHRLATIEDHLTTVLRATTSQNAGDDVCTNQQEVKHFAGLPDHGRGEGTMTDVERRLHQLMLSVRDFDGPPSASGPSSSWPRSTANIPLGGHEDEEEREKKECQVRIESCDERGYSIVTVSCKDRRRLMFDTVCTLTDLQYVIFHASVDSDEGYAFQEYFIRRIDGCALNTEGEKERVIKCLEAAIERRVCEGIRLELRATNRVGLLSDITRVLRENGLAVVRADIATQGEDAVNAFYVRDMSGNDVDMEFIKTMKREMGPIDLDVKNETPIISRTSPPNGNGRPRFSVGDILRSHVERLSHNIAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V174</accession>
    <name>A0A068V174_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00040825001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CONSTANS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739168">
        <property type="protein sequence ID" value="CDP14416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V174"/>
    <dbReference type="FunCoup" id="A0A068V174">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V174"/>
    <dbReference type="Gramene" id="CDP14416">
        <property type="protein sequence ID" value="CDP14416"/>
        <property type="gene ID" value="GSCOC_T00040825001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V174"/>
    <dbReference type="OMA" id="WYPQASS"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V174"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF131">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="12">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP14416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="412" mass="44877" checksum="3EE99C90A4D6791D" modified="2014-10-01" version="1">MGYMCDFCGEQRSIVYCRSDAASLCLSCDCNVHSANALSRRHSRTLVCERCNLQPAFVRCIEEKISLCPNCDWLGHGGSNTGSTHKRQAVSCYSGCPSAAELSTIWPFFLDFPLVGDSKCEQIMGSMSINEVSRDSQGAQGKKNIQDASVAVGVTNIQNVDKSTAWTGSSMLPYDAKLQNIELPAASTCAGSPKLSCFGAKGQTVCEDDSFYENFNMDEVDLSIENYDELFGAALDNPEKLFENDDIDGLFGMEISGADSNCQDAHLMEGSSMGRINGIQPACSTAASADSMMSCKTEPNICFARQAHSSLSFSGLTGESSAGDYQDCGASSFLLMGEPPWCPPCPESSNPASSRSNAVMRYKEKKKTRKFEKKVRYASRKARADVRRRVKGRFVKAGDAYDYDPMTPTRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1J3</accession>
    <name>A0A068V1J3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041040001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1J3"/>
    <dbReference type="STRING" id="49390.A0A068V1J3"/>
    <dbReference type="Gramene" id="CDP14526">
        <property type="protein sequence ID" value="CDP14526"/>
        <property type="gene ID" value="GSCOC_T00041040001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1J3"/>
    <dbReference type="OMA" id="AYEMTIN"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1J3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF17">
        <property type="entry name" value="GDSL ESTERASE_LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="40046" checksum="C883C44CEDF4A2DB" modified="2014-10-01" version="1">MKNRSSCNIAVLSYYLQATLALLVGWVMLQAALGSAAKPPAIFILGDSTVDVGTNSYLQESRARADFPLYGIDFPHSRPTGRFSNGLNGADFLARLTGYNSSPRPFLSLGSPLLSYLRNHAFRGANFASAGSGLLDLTGSALGVVPLSEQVKQFATLQGNLTAVRGSGATEAMLQKSLFCISIGSNDLFDYVVSNSSATPQEFIYLLMKEYENSIKTLYSLGARKFGIISVPPIGCCPTIRLLGAEGKCSDALNGLARAFYSALETLLYGIGSELEDLKYSLGNAYLMTINVINNPQPFHFTSVDKACCGFGKLNAERGCNATANLCLKRQEYLFWDQFHPTQAAANLAANTLYAGPPLYVSPINFAQLVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1X1</accession>
    <name>A0A068V1X1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription elongation factor TFIIS-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00039026001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1X1"/>
    <dbReference type="FunCoup" id="A0A068V1X1">
        <property type="interactions" value="2932"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1X1"/>
    <dbReference type="Gramene" id="CDP13893">
        <property type="protein sequence ID" value="CDP13893"/>
        <property type="gene ID" value="GSCOC_T00039026001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1X1"/>
    <dbReference type="OMA" id="MVKCNDE"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1X1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="236"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45124" checksum="C1441ACDE3A420C5" modified="2014-10-01" version="1">MEKELVELFEKAKKAADAASADGGADSSPEESRCLDALKRLKKLPINYDILVSTQVGKRLRQLTKHPRKSIQSMASDVVEMWKGIIVKETAKNRKNGNVEHEGSVKAEPGGADSGERTKVGRVNSIKLEGSVKAEPTGADSVSDKRFQRVSSVKVEKASTASSVKVERVDRSFSSTSEKAMKLETSSTEVKVEEDGKVSSGERMNVERITIEEKPNSDMRNTAPKLTSLLYTKDQVRDKMREIVAEALCKVTTEVDEDLREEVDACDPYRVATMVESAMFEKWGRSTGAHKAKYRSICFNIKDPNNPDFRRKVLLGQFPPNSIVYLSAEDMASDARQKQNEKIKEKALFECGRENSAKASTNAFKCGRCGKRETTYYQLQTRSADEPMTTFVTCVNCNNHWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V246</accession>
    <name>A0A068V246_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00042086001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739174">
        <property type="protein sequence ID" value="CDP14676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V246"/>
    <dbReference type="FunCoup" id="A0A068V246">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V246"/>
    <dbReference type="Gramene" id="CDP14676">
        <property type="protein sequence ID" value="CDP14676"/>
        <property type="gene ID" value="GSCOC_T00042086001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V246"/>
    <dbReference type="OMA" id="DECKREP"/>
    <dbReference type="OrthoDB" id="1873930at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V246"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF18">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT (PPR) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="508" mass="56798" checksum="ECEDE0395040A27C" modified="2014-10-01" version="1">MWIATAAAAAAASSSISLGPSSCHYCPSEGICCSTSYGITGSWTKSVAGVHRISAHSGLSFRCDNSFFGVTLWLPNGHENCNSRVSVAADYSDSLPDSSSYGGDNGYHPLEELRECRRTRVTKLTDAEIARSTVEANNRALLFFPSMVHCEPHEQVSWDDFPYVIDEYGDIFVEIYDKDNILQDPQASNPVNALIGMDISQYENRRIDTSEYGFLENNYGDDITYLNDYAEFEDSEMLAVRVDWGMPDSSSWVHPIYFAKCLTKVVSAEHVKMIDHPSNGVSVWGHLKPAYVDEELYLRRLFDDENNDGYTSGWTDGEGFSSSDCGSHKRSTIYRLDIMKMDLFSVYGEQACDGCMSYKLLLLDILYACGNHFQAYVGSCICDRCQLFLLLAISLEDFQDAEPDILVHSTAALVERFDEPGVRCNFALKALCKKKGLLVEGANLIGVDSLGMDVRVFSGSEVLTHRFPFKVRATSEAAADKQIQQLLFPRSHRKKHRTLEKLRDTDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2Q9</accession>
    <name>A0A068V2Q9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00042643001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2Q9"/>
    <dbReference type="FunCoup" id="A0A068V2Q9">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2Q9"/>
    <dbReference type="Gramene" id="CDP15080">
        <property type="protein sequence ID" value="CDP15080"/>
        <property type="gene ID" value="GSCOC_T00042643001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2Q9"/>
    <dbReference type="OMA" id="IAESNDM"/>
    <dbReference type="OrthoDB" id="1899087at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2Q9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000013">
        <property type="entry name" value="DNA polymerase III subunit gamma/tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054506">
        <property type="entry name" value="DnaA_N-like_STI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF0">
        <property type="entry name" value="PROTEIN STICHEL-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23007">
        <property type="entry name" value="DnaA_N-like_STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="344"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="990" mass="109649" checksum="592C5EF32D0F273B" modified="2014-10-01" version="1">MDGRRHSVDVPISRALVALRRVRSLRDPSTNSLSKFSPLVENLNWETNSNNAITLGFENKTKEFVNVETGMFDIENRRLDDERDRHGNGQQLYYSRKSNAELVSHEDSCQDGNKGSDPFRNMHVEGSTIGQPSLEMLCANKSLSERYCSNHRDKGLELACVASSTDCLEGVGSCNEPNEGSIHDEMLYRNRYSKKYQNRKQSRSCRSAAGDVLSRVGSPSLSMSDALLGGSSCGISLNGDEDADALDSRQCGCGIGHCWSRPPRLRESNHHLDAEDQPFLPAGAGEAHTSEWRRGCNHMNNGVTLYSESPRSLSQKFRPKSFSDLVGQNLVARSLLSSISNGRISSFYLFHGPRGTGKTSAAKIFAAALNCLSPDTAKPCGHCRECFLFFSGKGSNVKEVDSLKVNKTQRIRAIIKNAENSVSSSPFKVLIIDECHLLREDTWATFLNNLEDISCRVVFIMVTPDLHKLPRSAVSRSQRYHFPKIKEADVAGRLGKICLEEGFDFDQDALDYIATKSNGSLRDAEMMLEQLSLIGKKITMTLVYELMGVVSDDELFDLLHLALSSNTPETVKRARELMRSRIDPLHLVSQLANIIMDGLAGKCQEEASEIPRRLFGRSTSEADMQQLSHALKILSETEKQLRMSKNQTTWLTVALLQLSSVGSSLDSNESRLCIKTMQPRDGDFCSTSSTTESLKHLVTCARDSSESCKMGMQGREQTLESVWKTAAGICESSSLKSFLQKRGKLLSINLRQGLAVAELGFYHSKYVSKAEKKWKVIAGALQNALGYNVEIRINLILDSAGKEHAKVKKGYFSFSSCSRRLHRRSQSTTECESDPSEKLDSISTKPLTVDKYVETGSSESGSHNSHACCIGKELVRTIRNTDGNALSIALMTPKHQLGADKYRNCGCQDLFAPEQGKQPGCFPRTLRFQKANASNTSETIFWRTCLENNPASAVPHPVTQTHFCPSDPVVSCCRSVNLNNSCRNHVRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3C0</accession>
    <name>A0A068V3C0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance RPP13-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040737001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739166">
        <property type="protein sequence ID" value="CDP14378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3C0"/>
    <dbReference type="FunCoup" id="A0A068V3C0">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP14378">
        <property type="protein sequence ID" value="CDP14378"/>
        <property type="gene ID" value="GSCOC_T00040737001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3C0"/>
    <dbReference type="OMA" id="LAWEQWH"/>
    <dbReference type="PhylomeDB" id="A0A068V3C0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF51">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="165"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="423"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="681"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115639" checksum="66D4D6C7C46A6FF8" modified="2014-10-01" version="1">MAAALVGGSLLSAFLQVLFDRMARPEFLNLFHNREADDDLLKKLKTNLLTVGAVLDDAENKEIRNQSVKKWLEELHDTFYQAEDLLDKINTEALRIKVENEILPCTSSSKFLKRIMPEIETIVASLEGCIQQITPLGLQVVQSRIQSRQQFETPLVDETTIFGRDADKEKIIEMLLSEDANGDNITVVPIVGLGGLGKTTLARMVYKDFRVEVGFPTRAWVCVSEEYDATKITKELLRELNISFVEDENLFSLQVKLQVGLTKKKFLLVLDDVWNSNYNHWDNLRIPFKGGLQGSKIIVTTRNLSIARMMCKEESIHHLDFISDEDCWFLFKKHTFENRNDNQNLELEKIGKKIVKKCGGLPLAVKTVAGILRSRTTLEEWEEILISEEWTQLDNQNGPIPALRLSYIHLPSHLKRCFAYCAIFHKDYQFRKEEIIQLWQANGLLEYPGENKRIENMGEKCIHELRMRSLFHQLSESSFSMHDLVNDLARFVFGKYCLRLENHQEGDTTISGVRHFSFHPSYFDTFHKFNLLRETKNIRTFLPLRMDQDSHPMDHLSKKFLEDTLPQFMSLRVLSLSHYENIVKLPNSCSGLKQLRILDLSSTKIKELPKWVCTLYNLQSLLLSKCKELEELPANLRKLINLWCLDISETPLKKMPPQIGRLINLQVLTAFVIGKDSGSMIKELGKLPMLRDKLFLSGLENVSSGRDASLANMEGKKNLEKLTLKWNGDANNSQVARDVLDKLLPHSSIKQLKIDGYCGTTFPNWLGNSSLSYLESLNLSSCEYCFSLPALGQLRSLQSLEIVGMSHISVLTEDFYGDTSAIKPPFPSLKKLRIEKLPKWERWYIPECKVFNRLEELYIIDCPKLIGEFPQQLSSLQRLDISGCSELVRPNGRLSIFNGEIQQLLSLCEVRISALKTLKDLPLQLNQLSRLERLIIDDCGSLSPLHISLLPPSLKSLEYKRCCNLELENSSWDDGGSLKHLKFDTCESLKVKVEWLASFPILKQLRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V491</accession>
    <name>A0A068V491_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CHUP1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00043011001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V491"/>
    <dbReference type="STRING" id="49390.A0A068V491"/>
    <dbReference type="Gramene" id="CDP15324">
        <property type="protein sequence ID" value="CDP15324"/>
        <property type="gene ID" value="GSCOC_T00043011001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V491"/>
    <dbReference type="OMA" id="RIEGMQM"/>
    <dbReference type="OrthoDB" id="687739at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V491"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072699">
        <property type="term" value="P:protein localization to cortical microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040265">
        <property type="entry name" value="CHUP1/IPGA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342:SF10">
        <property type="entry name" value="CHUP1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
        <property type="entry name" value="PROTEIN CHUP1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50825" checksum="3D727534F429925A" modified="2014-10-01" version="1">MDSTSTKADVIKPVLLRAGIPLAITVAGFIVARITTRKRSSRLNTSSAENEASSRGEQTAEGCFPDVQSINSSSLSSLDAYHSITDTSNRNSEEELQHQHIFELEEEVLVLRNQIKDVHVREFELEVQYLRYHDMKEQELLLMELQNKLLLEITRVELLDEEISSVEADRKSFESVVVEYLKMLELLEISRSRNRLLQRKVKKLLRRTKEHSRVIKQQHMQIEAKEAEIFRNHQELEAKANIIRRRENEIKELKLAFGQLQMEKDELSRQMELANTAASSKIDADEATMVDYGRVAANPEQLEKEHAAAIKELIYLRWCNACLRHELLRKNLEQEDLQQRKDHRELNFGEISNFGWENEHDHSSWDHGDSCLNLPATGHAHPRSTQQKFIDKFRRWVEGSDKTKQKIEEKKKHNVSHSLLPHGPGYLHNPARKSYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V587</accession>
    <name>A0A068V587_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="9">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00016880001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
            <location evidence="9">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
            <location evidence="9">Extracellular space</location>
            <location evidence="9">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="9"/>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V587"/>
    <dbReference type="STRING" id="49390.A0A068V587"/>
    <dbReference type="Gramene" id="CDP15955">
        <property type="protein sequence ID" value="CDP15955"/>
        <property type="gene ID" value="GSCOC_T00016880001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V587"/>
    <dbReference type="OMA" id="MCIARER"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V587"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0052">Apoplast</keyword>
    <keyword evidence="9" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104042" description="Xyloglucan endotransglucosylase/hydrolase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP15955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="291" mass="33043" checksum="F8F5C250543E7740" modified="2014-10-01" version="1">MKSITCSNWLKLSVFMTLLLATSAGNFYQDAVTTFGDQRVKIAEGGRLLSLSLDKSSGSGFQSKNEYLFGRFDMQLKLVPGNSAGTVTTFYLSSVGQGHDEIDFEFLGNASGQPYTLHTNVYSQGKGDKEQQFKLWFDPTTFFHTYTIVWNSQRIIFLVDNIPIRVYNNHEAIGVPFPKNQPMRVYCSFWNADDWATQGGQVKTDWANAPFTVYYRNFNVKGDVCVPGSPCGSGSKSTDSLNTQEWETQGLDGKGRNRIRWVQQKHMIYNYCADRKRYPQGLPVECKRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V609</accession>
    <name>A0A068V609_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00016965001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739197">
        <property type="protein sequence ID" value="CDP16007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V609"/>
    <dbReference type="Gramene" id="CDP16007">
        <property type="protein sequence ID" value="CDP16007"/>
        <property type="gene ID" value="GSCOC_T00016965001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V609"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="46" mass="5189" checksum="A7863FA0DC513EAA" modified="2014-10-01" version="1">MDFCVTISGKERQGRSLKEESQLVSFPLFWGTRPIVAASLDQAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6G5</accession>
    <name>A0A068V6G5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00015338001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6G5"/>
    <dbReference type="STRING" id="49390.A0A068V6G5"/>
    <dbReference type="Gramene" id="CDP15493">
        <property type="protein sequence ID" value="CDP15493"/>
        <property type="gene ID" value="GSCOC_T00015338001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6G5"/>
    <dbReference type="OMA" id="RANSMIC"/>
    <dbReference type="PhylomeDB" id="A0A068V6G5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658294" evidence="4">
        <location>
            <begin position="30"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP15493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="547" mass="59948" checksum="ACC8224E319F32A2" modified="2014-10-01" version="1">MASSSSVKNKAFWLLLLFVSEFLAGVTLAAEDSQKQNLGTVIGIDLGTTYSCVGVYRNGNVEIIANDQGNRITPSWVAFTDTERLIGEAAKNQAALNPESTVFDVKRFIGRKFNDPEVQRDMKLLPYKVVNKVGKPYIDVKMKNGEMKLLSPEEVSAMVLQRMKQTAESYLGKEVKNAVVTVPAYFNDAQRQATKDAGTIAGLNVVLSTNGNTHLGGEDFDQRVMDHFLRKECERAKRALTTFEELNMDLFKKTMAPVKQALKDAGLEKSAIDEIVLVGGSTRIPKVQQLLKEFFDGKEPSRGINPDEAVAHGAAVQGAILGGHGGEETKDVLVIDVTPLSLGLETVGGVMTKLIPRNSGIPIKKSQVFTTYQDQQTTVSIKVYQGERSLTKDCHELGKFDLSGIPPAPRGVPQIEVTFGVDANGILQVTAMDKAAKKSNSITITNEKGRLTPEEIDRMVKEAEDMKSSIRDDEKVAGKIDSDDKESIETALKDALEWLDDNQNAEKLDYDEKMAELEAAFNPIIRKAYESSAGSSADPEDESNYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7D5</accession>
    <name>A0A068V7D5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00018266001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739208">
        <property type="protein sequence ID" value="CDP16404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7D5"/>
    <dbReference type="FunCoup" id="A0A068V7D5">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7D5"/>
    <dbReference type="Gramene" id="CDP16404">
        <property type="protein sequence ID" value="CDP16404"/>
        <property type="gene ID" value="GSCOC_T00018266001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7D5"/>
    <dbReference type="OMA" id="ADPVDIM"/>
    <dbReference type="OrthoDB" id="691258at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7D5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051863">
        <property type="entry name" value="HIPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811:SF27">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="91" mass="10069" checksum="147EDDE0A2B3EA3C" modified="2014-10-01" version="1">MSLISKLEGITSIALDPSKSTVTVIGEADPVCIIKQVRKFSRTAQLTSIGPPKEEKKDDKKDALPSLPKTCQRCDVWYVVSDDYFGHCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7H6</accession>
    <name>A0A068V7H6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDSL esterase/lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00016745001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739195">
        <property type="protein sequence ID" value="CDP15853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7H6"/>
    <dbReference type="STRING" id="49390.A0A068V7H6"/>
    <dbReference type="Gramene" id="CDP15853">
        <property type="protein sequence ID" value="CDP15853"/>
        <property type="gene ID" value="GSCOC_T00016745001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7H6"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7H6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044552">
        <property type="entry name" value="GLIP1-5/GLL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966:SF1">
        <property type="entry name" value="GDSL ESTERASE_LIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26437" checksum="4EE64D5AA6308055" modified="2014-10-01" version="1">MKMTKENRIELNLANSCIQLCLIVLLVVLASLTIPSDCFHHDDHHSETTAALFVIGDSLVDPGNKKYINTTTGRFCDGRVIPDFIAEDAKLPFLPPYLRIGYQYQLAFGTNFASGGAGALVETFPGLVIDLQKPLGLCSNGCWQHYRLFEENIQEKWEKIWGVLKLPPIGCLPRFRAADVAAGATGECNGQITAVAELHCVLLSKNLSTCRSSSKALDTHILTFLCINLIALQIKYVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7T6</accession>
    <name>A0A068V7T6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 CYP72A219-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00016916001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7T6"/>
    <dbReference type="FunCoup" id="A0A068V7T6">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7T6"/>
    <dbReference type="Gramene" id="CDP15983">
        <property type="protein sequence ID" value="CDP15983"/>
        <property type="gene ID" value="GSCOC_T00016916001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7T6"/>
    <dbReference type="OMA" id="GEVCITW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7T6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20642">
        <property type="entry name" value="CYP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000029">
        <property type="entry name" value="Cytochrome P450 734A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF273">
        <property type="entry name" value="CYTOCHROME P450 CYP72A219-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59822" checksum="C1FCDA5D0DF80237" modified="2014-10-01" version="1">METANLSAYTVYSSCLLLVVVGVSWKALNWVWFRPRKLEKRLKEQGFRGNPYKLLHGDIKEMSTLHKEAQSKNLNLSDDIVPRVIPQYLGAVKKYGKKTYLWLGPKPAMVIMDPEQVKEITQKVYVFQKPHGNPLRRMLTPGIVMYEGDKWTQHRKLLNPAFHIEKLKLMLPAFHKSASEVVNKWEKVVSPKGSAEVDVWPNLQALTSDAISRTAFGSNYEEGRRIFELQREQAEHIVEAGGSVYIYIPGFRFLPTKRHRRMKQITKEVNDSIREMIDTRKKAMRAGEARTDNLLGLMLQSNSQEIEKHGNKDYGMTTEEIIDECKLFYLAGQETTSALLVWTMIYLSRYPDWQARAREEVLQHFGANDPEFDGLNQLKIVNMILHEVLRLCPPITATARRIAEETKLGNLTIPVGVLLVLPIMLMHHDPDIWGEDVKEFKPERFAEGVSHATKGRLAFWPFGWGPRICIGQNFAMLEAKLAMSMILQRFSFELSPSYAHSPRVAVTLRPQYGAHLILRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8E8</accession>
    <name>A0A068V8E8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00019238001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NIPA (TC 2.A.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8E8"/>
    <dbReference type="FunCoup" id="A0A068V8E8">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16754">
        <property type="protein sequence ID" value="CDP16754"/>
        <property type="gene ID" value="GSCOC_T00019238001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8E8"/>
    <dbReference type="OMA" id="YYGPLAC"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF9">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP16754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="442" mass="48473" checksum="C91AF7D4EFE39AAF" modified="2014-10-01" version="1">MGEWIIGAFINLFGSIAINFGTNLLKLGHDERERQSAQGIDGTNGKHIIYFQSWRVGILFFAFGNCLNFISFGYAAQSLLAALGSIQFVSNIAFAYFVLNKTVTVKVLIATAFIVLGNIFLVAFGNHQSPVFTPEQLADKYSNVTFLLYCLILVLVVALHHSIYRRGELLLAVPGQDLKPYWQMLLPFSYAIVSGAVGSCSVLFAKSLSNLLRLSLSSGYQLHSWFTYSMLLLFLSTAGFWMARLNEGLSLFDAILIVPMFQIAWTFFSICTGFVYFQEYQVLDALRTTMFVLGVISVFIGISLLAPDDLKGGEAKDTSLVSVTSSLSTDVDRLVIPYEDSQIKDISSFARAMKVKAANLVVKAKAACSLSLGLGEDSLHASSVLVMPMVSSKMTGFRGSGFGRTKLFSPRGSGWSKISVDEEDRESMLETTSMLPQSISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9D0</accession>
    <name>A0A068V9D0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF538 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00005036001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068V9D0"/>
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        <property type="protein sequence ID" value="CDP17114"/>
        <property type="gene ID" value="GSCOC_T00005036001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9D0"/>
    <dbReference type="OMA" id="DECHDCG"/>
    <dbReference type="OrthoDB" id="1873537at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9D0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
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        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007493">
        <property type="entry name" value="DUF538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676:SF114">
        <property type="entry name" value="DUF538 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676">
        <property type="entry name" value="T31J12.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04398">
        <property type="entry name" value="DUF538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16940" checksum="D2763549208E0506" modified="2014-10-01" version="1">MSDDGTTPTVYEVLQEYGFPVGILPKGVTSYELDRSTGKFTVYLNETCSFTIDGYNIRYKSKVTGVISYQRLADLSGVQVKVLFFWLGIGEVTVDGDELDFSVGIASADFQVDNFYESPQCGCGFDCVNAAVGDGIGMYGSGSKFNWRRLFYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAM3</accession>
    <name>A0A068VAM3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019149001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAM3"/>
    <dbReference type="STRING" id="49390.A0A068VAM3"/>
    <dbReference type="Gramene" id="CDP16683">
        <property type="protein sequence ID" value="CDP16683"/>
        <property type="gene ID" value="GSCOC_T00019149001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAM3"/>
    <dbReference type="OMA" id="HIMPTEA"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAM3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000015">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="209" mass="23348" checksum="2A16676F243993A0" modified="2014-10-01" version="1">MDDEATWLMIRGMHTLIRDRDISKHDFVFYSDRLIRLVVEHGLGHLPFTEKQVVTPTGSVYTGVDFCKKLCGVSIVRSGESMENALRACCKGIKIGKILIHRDGDNGKQLIYEKLPKDISERHVLLLDPVLATGNSANQAIDLLIQKGVPESHIIFLNLISAPEGIHCVSKRFPSLKIVTSEIDVALNEEFRVIPGMGEFGDRYFGTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBK4</accession>
    <name>A0A068VBK4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00001232001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739278">
        <property type="protein sequence ID" value="CDP17977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBK4"/>
    <dbReference type="FunCoup" id="A0A068VBK4">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBK4"/>
    <dbReference type="Gramene" id="CDP17977">
        <property type="protein sequence ID" value="CDP17977"/>
        <property type="gene ID" value="GSCOC_T00001232001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBK4"/>
    <dbReference type="OMA" id="QTTVSWM"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000043">
        <property type="entry name" value="sugar transporter ERD6-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER ERD6-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="51"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP17977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="488" mass="52558" checksum="880714EF16FBE2E9" modified="2014-10-01" version="1">MEPQSIVDFDEEASNPLLRRASPDTESREDAEAGKISSPASSGATALVIFSTLISVLGSYVFGTAVGFSSPAQSGIVNDLGLSIAEYSVFGSIWTIGAMLGAIISGKIADFFGRRVAMGFAELFCLVGWTAISFSQNAWLLDIGRFLAGYGVGILSYVVPVYIAEITPKNLRGAFTAVNQLMICCGGSVMYVIGNFTSWRTLALIGTIPCILQLLGLFLIPESPRWLAKMDKWKECETSLQRLRGANANISQEAAEIIEYTEMLKQLSDTRMIDLFQRKYAHGLIVGVGLMVLQQFGGVNAIAYYASAIFESAGVSSRTGTLAMVVIQVPMTLLGTLLTDKSGRVPLLMISATGTLLGCFLTGLSFLLQDLQLWKDSPLLALIGVLIFTGSFSLGMGGIPWVIMSEIFPINVKGLAGSLVTVVNWLGSWIISYSFNFLTKWISSAGTFFLFSVASGLTIIFVAKLVPETKGRALEEIQASMVLFTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCW7</accession>
    <name>A0A068VCW7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00006395001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739348">
        <property type="protein sequence ID" value="CDP18665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCW7"/>
    <dbReference type="FunCoup" id="A0A068VCW7">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCW7"/>
    <dbReference type="Gramene" id="CDP18665">
        <property type="protein sequence ID" value="CDP18665"/>
        <property type="gene ID" value="GSCOC_T00006395001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCW7"/>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009704">
        <property type="term" value="P:de-etiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010218">
        <property type="term" value="P:response to far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009845">
        <property type="term" value="P:seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="133"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="619" mass="67650" checksum="F915C26186904B5E" modified="2014-10-01" version="1">MSTDKSKSCFASPMPTIHHTEIYTQYQTKMRVRWLSVSATMAILLSIASLPLLTQNTINNYTTFTSSFSNFLKIFRSKTVQRGVADLIVTNGTIFTSDDSLPFAQSMAIRSGRIIQVGDYSSVQDLAGPGTRELNLEGKMVVPGFIDSHVHLISGGLQMARVELHDVKSKDHFVDKVKEAVANMKQGSWLLGGGWNNDFWGGELPMASWIDDITPHNPVWLSRIDGHMGLANSLALKLAGTSSYMNDPDGGAIIRNSNGEATGLLVDSTMKLITSCIPEVSVDVRREALMRASNLALMRGVTTVVDVGRYFPGSSTETSWEDFSDVYTWADLVGKMLIRVCLFFPIETWARLRDLKYKAGPKLSEKIYLGGVKAFADGSLGSSSALFHEPYVDEPHNSGLEVADINSLHGMTVSADKAGLQVAIHAIGDKANALILDMYASVVSHNGFRDRRFRIEHAQHLVPGMASRFSEQAIIASVQPDHMLDDADSAIKKLGIERATKGSYVFQSLLASGTKLAFGSDWPVADINPLGSMRTAMKRIPSGWHEAWSSSECMNLSDALKAYTIWAAHGCFLDKDVGSISPGKLADFVVLSTDSWDEFSREGSAYVEATYMGGIRAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD70</accession>
    <name>A0A068VD70_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GSCOC_T00005143001</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="HG739253">
        <property type="protein sequence ID" value="CDP17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD70"/>
    <dbReference type="STRING" id="49390.A0A068VD70"/>
    <dbReference type="Gramene" id="CDP17628">
        <property type="protein sequence ID" value="CDP17628"/>
        <property type="gene ID" value="GSCOC_T00005143001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD70"/>
    <dbReference type="OMA" id="ETITHTN"/>
    <dbReference type="PhylomeDB" id="A0A068VD70"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000317">
        <property type="entry name" value="Inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF585">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="951"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="979"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDP17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136740" checksum="7E9262133F8289F0" modified="2014-10-01" version="1">MCCGRYNLEGLYLAENNFTGAIAVSIPNCSKLTFISHGYNKFCGGIPISFGKLRHLEFLELIDNNLTSDIASTIGSLQYLMYLSLANNSLQGAIPSTVGNIVFCYFISALLLATSMLASFSLAKTNISTDTMALLELKDHITSDPYSILAKNWSISSSVCNWIGVTCSYTHHHRVRALNISNTGLAGSIPSNLGNLSFLVSLDMGNNSFHGHLPEGMAHLRRIRFISLSHNNFTGEIPSWFRFLEKLQHLSLRNNSFTGFLPPPLFNISGLGVIDFSENNLSGIIPVDMCNNLPSLKGLLVSYEFSGRIPREVGNLQMLEELYLGGNNLEGQLITGGFFVFNSFFFVYAVLDFFFLFAFKNLCDNLPKIEFLYLIKNQLYGQIPSNIGKCSSLRELSLARNGFTGFIPQEFGNLTILEGLDISVNHLIGEIPKEIGNLTMIQNLYLYENNLTGFIPQEMGKLSKLESLDLELNRLGGPIPAWIFNISTIQFLSLSANSFFGSLPPNMCHVLKNLQGLYLAGNYLSGNIPMSISNCSRLTIIALLSNEFTGSIPESLGNLRQLNVLQLSNNKLTSESSSQELSLFSSLANCMLLRQISLDRNPLNGVLPNSLGNLSRSIEKIFAFGSGIMGSIPGSIGNLSNLIVLRLDNNQLTGSIPTSVKGLGKLQGLYLHNNIITGTLSPDLCNLHMLNYFNISQNQVSGSIPGCFGNITSVRHIDLSFNKITSSVPISLWNLKDLLELRLTSNFFNGSLAPEIGKLKAVTWLDMSLNHFSGNIPSTIGDLQRLMQLSLANNNLEGSIPSTIADIQSLDYLDLSHNNLSGSIPKLMENLTHLTYLNVSSNDLRGEIPSEGPFTNFTYDSFAFNRALCGAPRFHLPPCQTISRRKSRTRKTVLIAIILPGMLSVVIVAGLGTVFHRYKKKSKIPSQTGLSSLIEQPRISYYELLQATNGYSQENLLGVGSFGSVYKGILNDGKILAVKVFNLQLERAFRSFDAECNILRNLRHRNLTKVITSCSNPDFKSLVLEFMPNGSLEKWLHSENCSLDVMQRLNIMIDVACALQYLHHGYTTPVIHCDLKPSNVLLDQDMVAHVSDFGIAKMLSEEETITHTNTLATLGYIAPEYGSEGLVSTKCDVYSYGIMLMEMLTRKKPNDEMFDGNLSLRGWVCGSIANAIMDILDVNLIRSNEEYSTQELECISSIMKVALNCSKESPNERSNIEYALAALNHIKLHLLSCYRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDR2</accession>
    <name>A0A068VDR2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00001030001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP18985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDR2"/>
    <dbReference type="FunCoup" id="A0A068VDR2">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDR2"/>
    <dbReference type="Gramene" id="CDP18985">
        <property type="protein sequence ID" value="CDP18985"/>
        <property type="gene ID" value="GSCOC_T00001030001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDR2"/>
    <dbReference type="OrthoDB" id="1925932at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDR2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF167">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP18985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="241" mass="27336" checksum="719D6D64CCB33A40" modified="2014-10-01" version="1">MCILFINDIVCENNRCIVSNDTGGNYYYGRTAGRRHYRGVRRRPWGKWAAEIRDPKKAARVWLGTFDMAEDAALAYDEAALRFKGTKAKLNFPERVVQGVKYSQSQLHCPATVSSSSSLSRQQYNPNPQDATETTINPSNTNVPSDMMTMTNYPHLLQYAQLLSSTDAELPYYASALYDRQQLLQPNPQITSPSAHVTPGLHRQRQEDFSSFSSEQCDYQSFCSSDFLKYGKDFDPKSPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE58</accession>
    <name>A0A068VE58_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00004628001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739412">
        <property type="protein sequence ID" value="CDP19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE58"/>
    <dbReference type="STRING" id="49390.A0A068VE58"/>
    <dbReference type="Gramene" id="CDP19016">
        <property type="protein sequence ID" value="CDP19016"/>
        <property type="gene ID" value="GSCOC_T00004628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE58"/>
    <dbReference type="OMA" id="DAKRTIC"/>
    <dbReference type="OrthoDB" id="1914518at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VE58"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="94"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="347" mass="40091" checksum="62B070C739E6CF06" modified="2014-10-01" version="1">MIKNFQPILHSALVYIDDILLFKILFLGMKISNGTCTPEQQVGQSVKDFPEENLTKTQVQQFLGLVNYVREFIPKAAKHISPLTKMLKKAPPSWGSSQTQAIQKLKQELVNLPTLHIPTEGKKILQTDASDKYWGAVLLEEDNKGTRHYCGFSSGKFKAFEQHYHSIFKEILAIRNGIKKFSFFLISHHFLVEMDMGSFPKMLHFKQKSVPHPQLLRWSAWFSQYSFDVKHIKGKKNIVADFFSRKEPIPQQVLYCLMFTSVQPVTAPPSPKVNQRVWRIACPTLARTRSLSSSEIRYNLETKRKIIPKLKTYIYIHIHLNRNTIPIRTKVLVLTTSNLIQALVREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFX1</accession>
    <name>A0A068VFX1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_613</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00001689001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739697">
        <property type="protein sequence ID" value="CDP19680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFX1"/>
    <dbReference type="FunCoup" id="A0A068VFX1">
        <property type="interactions" value="3325"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFX1"/>
    <dbReference type="Gramene" id="CDP19680">
        <property type="protein sequence ID" value="CDP19680"/>
        <property type="gene ID" value="GSCOC_T00001689001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFX1"/>
    <dbReference type="OMA" id="SSPNMKF"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFX1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000413">
        <property type="entry name" value="General transcription factor 3C polypeptide 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="871" mass="99230" checksum="F5B5C66B43BEED72" modified="2014-10-01" version="1">MDPLAFTKEDASGLQPYEQFQRLEHHYEALAAKKRKARLQPIPQGEVPVAKKPRQQQEDVSGATMEEIMELMNYGSRRRSRKPKRRGRRKGSRNKVSPEVTRKLGDATLHYAHGRYGEAIGVFYEVIRLSPNLPDPYHRLGLIYNEMGDKKRALDFYMIAAHLTPKDASLWKLLVTWSIEQGDTGQARYCLSKAITADPEDINLRFHRASLYVELGDYLKAADSYEQISQLCPDNVNVLQTAAQLYKKSGQSELAVRILESYLRNCCKEPDLNVVDILASLHMEGNAHIKALEHIEHAQQVYCTGKEMPLCLRTKAGICHIHLGNFVKAEALFNVLRHENLHDHPQLIIEIGDSLMNHGHYESALEYYMMLVGDDVKNNSCLYLKIAECCSCLGKRLQSIDYFYRALDKLENTVDARLALSSLLLEENKDDEAISVLCPPKESESLFNLNLNAAKPWWLNGKIKLRLSQIYKAKGLLEAFVDVIFPVVRETLFLETIQQKVRPRKRLSKSVLSERIKILDHVRTDTVFHGFRPVASASDLSRASRAKKLLKKKEAKRAAALAAGIEWISDDSEDESPQQAPRELPLPNLLRDAEHHYLIIELCKSLLSLKKYWEALEIINLTLKLASNVLSVERNEELRTLGAQIAYNIADPAHGFDYARYIVNQRPYSFSAWNCYYKVISKLDSRYSKHNKFLHTMRTKHKSCVPLTLIFGHQFTMISQHQAAVREYLEAHKLMPDIPLINLCAGTALINLALGHRLQNKHQSVVQGLAFLFNNLQLCRYGQEALYNIARAYHHVGLVSLAAVNYEKVLTMHESDCPMPNLPNEKPDGLASPKPGYCDLRREAAYNLHLIYKKSGAIDLARQILKDHCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFY0</accession>
    <name>A0A068VFY0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00002340001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739608">
        <property type="protein sequence ID" value="CDP19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFY0"/>
    <dbReference type="FunCoup" id="A0A068VFY0">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFY0"/>
    <dbReference type="Gramene" id="CDP19512">
        <property type="protein sequence ID" value="CDP19512"/>
        <property type="gene ID" value="GSCOC_T00002340001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFY0"/>
    <dbReference type="OMA" id="QAKCPKD"/>
    <dbReference type="OrthoDB" id="696558at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFY0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd01958">
        <property type="entry name" value="HPS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027923">
        <property type="entry name" value="Hydrophob_seed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051636">
        <property type="entry name" value="Plant_LTP/defense-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31731">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14547">
        <property type="entry name" value="Hydrophob_seed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655756" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="133" mass="13786" checksum="8D1DF38D3C22CA98" modified="2014-10-01" version="1">MVGSKGIAIIILLNLIFFTCVSSYKVVPCPPPRKPAPSTTPPAPKKPAKCPKDALKFGVCGDWLGLVHEVIGAKPSGECCALIKGLADLEAAVCLCTAIKANILGAIEVKIPVAISMLINSCGKKVPEGFKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG99</accession>
    <name>A0A068VG99_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00007751001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">cv. DH200-94</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00007751001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG99"/>
    <dbReference type="OMA" id="MENDLGH"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
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    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF38">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOTIDE TRANSPORTER 3-RELATED"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="205" mass="22673" checksum="F6F91952EC8E970C" modified="2014-10-01" version="1">MADMNGSPTPARLEGKLTAIVVCWVLGLGTLVAWNTMLTVGDYYYALFPRYHPARVLTLVYERFALGTIAILAYKEAKIDTRKRNLAGFTLFFLSTFALLIVSLPFCKNCRIGNYIGICIIVAVFGTADAHIEGGMVGDLSLMCPEFIQSFFAGLAASGALTSALRMMTKAAFDKTNQGLRKGVSMFSSFKLHRFRKCCHVFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGA4</accession>
    <name>A0A068VGA4_COFCA</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00009828001"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="entry name" value="WHIM2_dom"/>
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    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
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    <dbReference type="PANTHER" id="PTHR15546">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN, 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15546:SF2">
        <property type="entry name" value="DDT DOMAIN-CONTAINING PROTEIN DDB_G0282237"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="6">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="5">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH12</accession>
    <name>A0A068VH12_COFCA</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005947001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739843">
        <property type="protein sequence ID" value="CDP19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH12"/>
    <dbReference type="STRING" id="49390.A0A068VH12"/>
    <dbReference type="Gramene" id="CDP19882">
        <property type="protein sequence ID" value="CDP19882"/>
        <property type="gene ID" value="GSCOC_T00005947001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH12"/>
    <dbReference type="OMA" id="HITDYIR"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF298">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="327" mass="37301" checksum="1ADA51E2AFC78AF2" modified="2014-10-01" version="1">MSFGLISHKITGKIANGSNGDVAADSYHRYKEDIKLLKEMNADSYRFSISWPRLYNDLQMAKISKGINEKGIEYYNKLIDKILAYGLKPIVTIFHWDLPQALDEEYGGFLSPKIVKDFHDYANLLFARFGDRVKDWITFNEPWTFSSNGYDSGTSAPGRCSAWMNNNCTGGNSGTEPYLVAHHQLLAHADVVKLYRRVYQARQKGQIGITLVAEWMVPFSNSPLDQRAAIRALDFMFGWFMNPLVYGDYPASMRILVRDRLPKFTPKQSKELIGSYDFLGLNYYTANYAAHVTTPPNKVNLSYSTDAQVNVTSWLHIYPKGIWDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI37</accession>
    <name>A0A068VI37_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00010154001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739522">
        <property type="protein sequence ID" value="CDP19333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI37"/>
    <dbReference type="STRING" id="49390.A0A068VI37"/>
    <dbReference type="Gramene" id="CDP19333">
        <property type="protein sequence ID" value="CDP19333"/>
        <property type="gene ID" value="GSCOC_T00010154001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI37"/>
    <dbReference type="OMA" id="SIAMIFP"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VI37"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001049">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF831">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP19333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="147" mass="16478" checksum="CA9F9AA500A89F1F" modified="2014-10-01" version="1">MAAWEAEKARTVCVTGAGGYLGSWLVKLLLSRHYTVHATLRNPEDEKYVHLKKLDKAAENLKLFKADLLDYNSISAAIRGCDGVFHVASPVPSGSVPNPEARPFSIFSIAMIFPSFGFPRITFLTDLLFMGDSYCHYRLYFFAFCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VII1</accession>
    <name>A0A068VII1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">DH200=94 genomic scaffold, scaffold_1423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00001485001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG740507">
        <property type="protein sequence ID" value="CDP20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VII1"/>
    <dbReference type="FunCoup" id="A0A068VII1">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VII1"/>
    <dbReference type="Gramene" id="CDP20610">
        <property type="protein sequence ID" value="CDP20610"/>
        <property type="gene ID" value="GSCOC_T00001485001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VII1"/>
    <dbReference type="OMA" id="RCEDHIS"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VII1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000084">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000043">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045274">
        <property type="entry name" value="WAK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005:SF515">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658953" evidence="17">
        <location>
            <begin position="25"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="375"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="655"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="706" mass="77830" checksum="A5FF134B093279B4" modified="2014-10-01" version="1">MSPMSLSFLLFLLAWIITFPVSPAVGSLAKPGCSDTCGNVRIPYPFGIGPGCSLNESYTIICTSSKPYLSNLNLEVLNVSLRNRTVTVSTTVTPFCSSGSQTSSISSWRSNSSDLGGTPFFYSKTYNNLVIFGCGNAVLINQNDNKILSGCTSTCEFNSPAQAIDTSSCYGVNCCETTIPFYLSKYHLNFTASRFSLGGTGNCSSVFLADQNWSPEKFSESTQSVPVVLAWTLGRNDVQAIYRCPYEMTYLELEAGGNLATFMCPTCEFGGTDPQEINPYLQEQCGPRFIVDPGRRNLKAALIGVFAGIGVLIFIAISFTSYKLVKRRRDKMIKEKFFKRNGGLLLQQQLSGDDRVINKTRIFTAKELDKATDHFNENRVLGRGGQGTVYKGMLADGNLAAIKKSKKVDESQLGEFINEVVILSQVNHRNVVKLLGCCLETEVPILVYELIPNGTLFSLIHNENDDEFPFTWSLRLRMAAEVAGALAYLHSATSVPIYHRDIKSSNILLDAKYTAKVSDFGTSRSISIDKTHFTTMVKGTFGYLDPAYFQSSQFTEKSDVYSFGVVLVELLTRKKPVSSELEEDSHLSLATRFLITMDENRLNSILDPELQDERTEEEVVAVAKLAQRCLNLNGKKRPTMKEVATELDSIKMSANQSTNQANYESQGFKKEGSKPVAFSDNNPSWTSTGTNSITLSSAAYPDTNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ28</accession>
    <name>A0A068VJ28_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00007586001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:18945"/>
            <dbReference type="Rhea" id="RHEA-COMP:11676"/>
            <dbReference type="Rhea" id="RHEA-COMP:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="4"/>
    <dbReference type="EMBL" id="HG740496">
        <property type="protein sequence ID" value="CDP20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ28"/>
    <dbReference type="FunCoup" id="A0A068VJ28">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJ28"/>
    <dbReference type="Gramene" id="CDP20599">
        <property type="protein sequence ID" value="CDP20599"/>
        <property type="gene ID" value="GSCOC_T00007586001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ28"/>
    <dbReference type="OMA" id="CAHCRIE"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ28"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000002">
        <property type="entry name" value="Prolyl 4-hydroxylase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF238">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655941" description="procollagen-proline 4-dioxygenase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="140"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="18">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="317" mass="35007" checksum="900B3BEE0C228F39" modified="2014-10-01" version="1">MESRVILLLLLCLLSIPSDLSVSAGQFSRWGGGKKLKGSAVKLATGASSAPFDPTRVTQLSWKPRAFIYRGFLTNEECDHMINLAKNKMEKSMVADNDSGKSIESEVRTSSGMFLKKHQDDIVGGVEAKIASWTFLPVENGEAMQVLHYEHGQKYEPHFDYFHDKENQKLGGHRVATVLMYLSDVAKGGETVFPSSEKKETQPKGDDDWSDCAKNGYAVKPRKGDALLFFSLHPDATTDPLSLHGSCPVIEGEKWSATKWIHVRSFDALSTSEDCVDKDPNCPHWAASGECEKNPLYMVGSEEAVGYCRESCKICSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ43</accession>
    <name>A0A068VJ43_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013394001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740953">
        <property type="protein sequence ID" value="CDP20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ43"/>
    <dbReference type="Gramene" id="CDP20845">
        <property type="protein sequence ID" value="CDP20845"/>
        <property type="gene ID" value="GSCOC_T00013394001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="50" mass="5635" checksum="8E2AF65FF03CD4FA" modified="2014-10-01" version="1">MLGSILKRSILKRYRFVNRGHGTVVPLSTPQLMSSQKPKPILEVKLMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJD4</accession>
    <name>A0A068VJD4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00001381001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740670">
        <property type="protein sequence ID" value="CDP20697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJD4"/>
    <dbReference type="Gramene" id="CDP20697">
        <property type="protein sequence ID" value="CDP20697"/>
        <property type="gene ID" value="GSCOC_T00001381001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJD4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="76" mass="8550" checksum="DA86CB2D4C1FD19E" modified="2014-10-01" version="1">MSYGKLALNYFLKDKNFCMQGVDTSAYSSLINPVHSLSTEDISFGVFFDEVIYEITLEICFISSTPLPKTTDILII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKN7</accession>
    <name>A0A068VKN7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_3761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00003528001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG742845">
        <property type="protein sequence ID" value="CDP21390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKN7"/>
    <dbReference type="STRING" id="49390.A0A068VKN7"/>
    <dbReference type="Gramene" id="CDP21390">
        <property type="protein sequence ID" value="CDP21390"/>
        <property type="gene ID" value="GSCOC_T00003528001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKN7"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKN7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF223">
        <property type="entry name" value="ABC TRANSPORTER A FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="105" mass="11311" checksum="8BE206BA0F6BAF2A" modified="2014-10-01" version="1" fragment="single">LGSNGAGKSTLISCLTGITPVTHGDALIYGNSIRNSKGMSTIRRLARFDSLWNALSTKEHLHLFANIKGLPMATRKSEVKRLLADVDIDKIANVRAGSYSGGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL10</accession>
    <name>A0A068VL10_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_4551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00005953001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG743635">
        <property type="protein sequence ID" value="CDP21500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL10"/>
    <dbReference type="InParanoid" id="A0A068VL10"/>
    <dbReference type="PhylomeDB" id="A0A068VL10"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="361" mass="40705" checksum="3C286AA6A456C414" modified="2014-10-01" version="1" fragment="single">LEIKENCHVSLAEKVLSNIANLSSLELRRGRRQLAEHIRSLKLVRRPESSLSIVGCDSLPTDTLERLCLFPTLQHVELRDADNITTLRGMSCAACLKTLAVRYCFNLRELPEDLYQFQALEYLEISCCPRIDSFGYPNPKNSFGQKGLLKSLERFTVDMCNALTRLPAEMFESCTSLRELSLSCCRSLVSFPLDFRRTPSLESFSLQWCPNWIAEMPSGFGYLTSLRTVSIGPFSDYSVIEFDWAGLASSSSLRHVSLFGMRDTKSLPHQLQDLTTITSLSLLLFGAIEALPDWLGNLASLDELILRGCPKLEYLPSAAAMERLKLRRLAIDGCPLLERRCTPESGSEWSKISNISERQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL66</accession>
    <name>A0A068VL66_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_3494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003172001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742578">
        <property type="protein sequence ID" value="CDP21342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL66"/>
    <dbReference type="Gramene" id="CDP21342">
        <property type="protein sequence ID" value="CDP21342"/>
        <property type="gene ID" value="GSCOC_T00003172001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="70" mass="7978" checksum="6F3A83F7AC083086" modified="2014-10-01" version="1">MFLNHIFEDILIRVTFLHYCLISLAALTKEILESHNYLDRDVRFTASALIPTNIPSGIKVILVTHPRTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMF1</accession>
    <name>A0A068VMF1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_6407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00001059001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG745491">
        <property type="protein sequence ID" value="CDP21764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMF1"/>
    <dbReference type="STRING" id="49390.A0A068VMF1"/>
    <dbReference type="Gramene" id="CDP21764">
        <property type="protein sequence ID" value="CDP21764"/>
        <property type="gene ID" value="GSCOC_T00001059001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMF1"/>
    <dbReference type="OMA" id="MATIKCF"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMF1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00257">
        <property type="entry name" value="beta-trefoil_FSCN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000067">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057232">
        <property type="entry name" value="DUF7910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF14">
        <property type="entry name" value="CELLULASE CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
        <property type="entry name" value="FASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25490">
        <property type="entry name" value="DUF7910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658794" evidence="5">
        <location>
            <begin position="21"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7910" evidence="7">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="221"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP21764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="497" mass="55564" checksum="6801EF6BED0FC0C3" modified="2014-10-01" version="1">MATIKCFFILLSCFFSISNGRVPPAEFPVKAVNLGGWLVTEGWIKPSLFDGIHNKDLLDGTGIQFKSAKSGKYLSAETFKIGGSAKIVAKKTSAAEWETFKLWRVDSSNYSFRAANTQFVALGLDGKQFQSLITVAKDPTIRETFEIIRKTDDLNRVRIKGLNGFFWQVKSEGVVTADWDRFNTTWEDDDPSVFLITTVGGYQGEYQVTNGYGPLTAPQVMKEHWNTYIVENDFKFIAENGLNAVRIPVGWWIAGDPNPPKPFVGGSLQALDNAFLWAQKYGLKVIIDLHAAPGSQNGMEHSATRDGSLEWGLTDESIQQTVANPSLLAVELLNEPLAPGVALDTLTRYYRDAYDAVRKHSSTAYVILSNRLGPADHSELFALASVLTKPVIDVHYYNLFSTIFTNMTVQQHIDYVKTNRTAELASITSPNGPKILVGEWVAEWDVKGATRQDYQAFARAQLHAFEKATFGWAYWTLKNAKEHWSLEWMINNGYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMS0</accession>
    <name>A0A068VMS0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="8">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00005371001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741263">
        <property type="protein sequence ID" value="CDP20978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMS0"/>
    <dbReference type="STRING" id="49390.A0A068VMS0"/>
    <dbReference type="Gramene" id="CDP20978">
        <property type="protein sequence ID" value="CDP20978"/>
        <property type="gene ID" value="GSCOC_T00005371001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMS0"/>
    <dbReference type="OMA" id="PYREGPV"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMS0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP20978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="74" mass="8435" checksum="FB1728F37101B63D" modified="2014-10-01" version="1" fragment="single">MSRSLGIPVKLLHEATGHIVTVELKSGELYRGSMVECEDNWNCQLENITFTAKDGKVSQLEHVFIRGSKVRYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN12</accession>
    <name>A0A068VN12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00008276001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG748156">
        <property type="protein sequence ID" value="CDP22017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN12"/>
    <dbReference type="STRING" id="49390.A0A068VN12"/>
    <dbReference type="Gramene" id="CDP22017">
        <property type="protein sequence ID" value="CDP22017"/>
        <property type="gene ID" value="GSCOC_T00008276001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN12"/>
    <dbReference type="OMA" id="CYNEVER"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33491">
        <property type="entry name" value="OSJNBA0016N04.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656095" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP22017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="353" mass="38333" checksum="D26501CB50C5101C" modified="2014-10-01" version="1">MGFNRLILPMLLHLVIALMLSSASTLTSPTFSIARPGCQDHCGNVSIPFPFGITEGCYLNEQFFINCTNSSTSVPQTVLQNAVDVTEISLEGQVHLMQDIASDCYNKNGSLLNKKSPWIELSDRFTFSSTANKFIAVGCDALAIVKGFGQNRSYATGCIPSCDYKEDVIDGSCSGIGCCRTDTPPGAWNINVSLTSLNNHTKVWDFNPCSYAFVVEEKAFNFSASNLTNLSDDLSLPVVVDWTIEEGSCEVAQRNTTSYACSGKNSHCYEPFKGLGYRCSCDQGYEGNPYLPDGCQDINECQDPTLHNCTKNSVCHNTLGNYTCPCLKGYHGDGRGGDGCSPDQINWSMIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNF6</accession>
    <name>A0A068VNF6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003190001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741992">
        <property type="protein sequence ID" value="CDP21233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNF6"/>
    <dbReference type="Gramene" id="CDP21233">
        <property type="protein sequence ID" value="CDP21233"/>
        <property type="gene ID" value="GSCOC_T00003190001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNF6"/>
    <dbReference type="OMA" id="PAFCTET"/>
    <dbReference type="OrthoDB" id="1720991at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNF6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053098">
        <property type="entry name" value="Petuviruses_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028919">
        <property type="entry name" value="Viral_movement"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435:SF1">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01107">
        <property type="entry name" value="MP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="455" mass="51611" checksum="A271017705D5E85A" modified="2014-10-01" version="1">MASSSSTAVSIPNGLSLNKANSSKLDYLYEVSVEPEVVNPTSLPLIIPYTIFAKMSFSPSQVIKSLIQYHPKGVKEYIQASKIDQHPIPATKKEQFITLHIPDDFPLQWRQQGYTHMHFGAIRISLSYHGRKGLPVVARVALLDTRFTQYQHACIATVETTLNAGTVFVTLFPNFNMSLADPHLLDALKVQVQIVGADQVQDAIAATLHYQMVYRVQNHALDLKVLGSEDALLIQVDEKNSTSCIHVPRQISKSNLVQLLPNSWITDYEQLHTQANEPLESSNSKITKTTEGRTAISFDHSYLKSSIKTLPSIMLAELPLKLPTQEEKLWGRYEEKCQKGFLQDIIDHFNDKGEPVYHFQDPISGHIYFDTCTRCEECYWAEQLELDVSEISFKKRSKPVDPQPFEPCLCKSDPKPQNPDADNFQATRSSFDGYQIPSNWVYHVPTKKKILHPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQZ2</accession>
    <name>A0A068VQZ2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_10887</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00012284001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG749971">
        <property type="protein sequence ID" value="CDP22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQZ2"/>
    <dbReference type="STRING" id="49390.A0A068VQZ2"/>
    <dbReference type="Gramene" id="CDP22133">
        <property type="protein sequence ID" value="CDP22133"/>
        <property type="gene ID" value="GSCOC_T00012284001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQZ2"/>
    <dbReference type="OMA" id="DSVIFWI"/>
    <dbReference type="PhylomeDB" id="A0A068VQZ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001659075" evidence="8">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="37567" checksum="D6F82290F7298D7E" modified="2014-10-01" version="1" fragment="single">MERACYYFPVGLLLATSLLAVGTSDIITDKSTLVAFKNHIVLDPHSIVAKNWSISSSVCDWIGVTCDSSRQRVVTLNISNMGFAGTIPPQLGNLSFVVSLDMSNNNFYGHLPKGMSHLRRLNFMALGNNILTGEIPSWLGVLDRLQYLSLRENNFVGHLPANICDNLPNLKELDLYWNQLSGQILSGLSNCSGLKSLDLSLNQFNGYIPKAAGNLKMLEELHLYYNNLEGYFLVARNGENMLLLSYRIFIRHFSSTIPPQLGNLSFLVSLELSSNHFRGHLPEGMSHLRRLSFMALSNNNLTGEIPSWLGVLDRLQYLSLTENNFLGDLPANICDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKV9</accession>
    <name>A0A068TKV9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00014152001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKV9"/>
    <dbReference type="FunCoup" id="A0A068TKV9">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TKV9"/>
    <dbReference type="Gramene" id="CDO96955">
        <property type="protein sequence ID" value="CDO96955"/>
        <property type="gene ID" value="GSCOC_T00014152001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKV9"/>
    <dbReference type="OMA" id="HGLWPPM"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKV9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO96955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30714" checksum="05001BFB4A7637A2" modified="2014-10-01" version="1">MRGTGKRPIQAVKTWVRRQPPKVKGFLAVISGMAALVLLRAIVHDHDNLFVAAEAVHSIGISVLIYKLMKEKTCAGLSLKSQELTAMFLAVRLYCSFVMEYDIHTLLDLATLATTLWVIYMIRFKLKSSYMEDKDNFALYYVVVPCAVLAILIHPSTSHHIINRIAWGFCVYLEAVSVLPQLRVMQNTKIVEPFTAHYVFALGIARFLSCAHWVLQVLDSRGHLLTALGYGLWPSMVLISEIVQTFILADFCYYYVKSVFGGQLVLRLPSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TL93</accession>
    <name>A0A068TL93_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00013817001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TL93"/>
    <dbReference type="STRING" id="49390.A0A068TL93"/>
    <dbReference type="Gramene" id="CDO96712">
        <property type="protein sequence ID" value="CDO96712"/>
        <property type="gene ID" value="GSCOC_T00013817001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TL93"/>
    <dbReference type="PhylomeDB" id="A0A068TL93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="115"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO96712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="399" mass="45165" checksum="535A98E76F75B270" modified="2014-10-01" version="1">MSLYYPSFKESREIGQGVYKGKSSIDRYIGEHAVLLTGFDKEEDGTEVFEFKNTSGLAFGAQGFGKLKRDLIISISYPKGVLKVDKIDKDGIGHKYIMVRGLQIHVAEIGAGSSVVLFYYGFPEMWYSWRYQMLAVANKGFRAIVPDYQGYGVSEMPQEPEKTTFLRLVNDLFAVLRNMGISKVFLVAKGFGVQIASLFAIRHQEMVNGIITIGPPSIPGTQFSPFQNLSPKCYLSRWKDPQKAKDEFNCLDPKAIVRKIYILFSQDEIPETCDGENNLDLIDDSLCPSWITEDDLTFYGTWYERTGFSTALKVPLSLDENVKLVNQQIRVPALMIIAGKDHLLKFPGIHDYIQCERVNKFVSDLEMKYLPEGTHFVQEQLPDDVNEAILTVMSKHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLR1</accession>
    <name>A0A068TLR1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00014100001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLR1"/>
    <dbReference type="FunCoup" id="A0A068TLR1">
        <property type="interactions" value="2310"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLR1"/>
    <dbReference type="Gramene" id="CDO96917">
        <property type="protein sequence ID" value="CDO96917"/>
        <property type="gene ID" value="GSCOC_T00014100001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLR1"/>
    <dbReference type="OMA" id="NPEVTHH"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04133">
        <property type="entry name" value="Rop_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000535">
        <property type="entry name" value="rac-like GTP-binding protein RAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO96917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="21698" checksum="A1E0B3CF1495B2A0" modified="2014-10-01" version="1">MSASRFIKCVTVGDGAVGKTCLLISYTSNTFPTDYVPTVFDNFSANVVVDGSTVNLGLWDTAGQEDYNRLRPLSYRGADVFILAFSLVSKASYENVSKKWIPELRHYAPGVPVILVGTKLDLRDDKQFFVDHPGAVPITTAQGEELRKLIGAASYIECSAKTQQNVKGVFDAAIKVVLQPPKHKKKKKRKGQKGCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMC7</accession>
    <name>A0A068TMC7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00014336001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-heme b-[protein] + nitric oxide + H2O = Fe(II)-heme b-[protein] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:77711"/>
            <dbReference type="Rhea" id="RHEA-COMP:18975"/>
            <dbReference type="Rhea" id="RHEA-COMP:18976"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:77713"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the plant globin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMC7"/>
    <dbReference type="FunCoup" id="A0A068TMC7">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMC7"/>
    <dbReference type="Gramene" id="CDO97099">
        <property type="protein sequence ID" value="CDO97099"/>
        <property type="gene ID" value="GSCOC_T00014336001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMC7"/>
    <dbReference type="OMA" id="GERHVEY"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMC7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001032">
        <property type="entry name" value="Leghaemoglobin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019824">
        <property type="entry name" value="Leghaemoglobin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22924">
        <property type="entry name" value="LEGHEMOGLOBIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22924:SF39">
        <property type="entry name" value="NON-SYMBIOTIC HEMOGLOBIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00188">
        <property type="entry name" value="PLANTGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00208">
        <property type="entry name" value="PLANT_GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15347" checksum="CCFCD158873E9A20" modified="2014-10-01" version="1">MKKNSGEWGLKFFLRIFEIAPSAKKLFSFLKEPNAPLEQNPKLKTHAKTVFVMTCEAAVQLRKAGKVVVRESSLKKLGATHFKYGVVDEHFEVTKFALLETIKEAVPEMWSTEMKNAWGEAYEQLVAAIKTEMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMS8</accession>
    <name>A0A068TMS8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00014614001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMS8"/>
    <dbReference type="STRING" id="49390.A0A068TMS8"/>
    <dbReference type="Gramene" id="CDO97307">
        <property type="protein sequence ID" value="CDO97307"/>
        <property type="gene ID" value="GSCOC_T00014614001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMS8"/>
    <dbReference type="OMA" id="HGHEAGC"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMS8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO97307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="401" mass="43435" checksum="5904F0E011433419" modified="2014-10-01" version="1">MQANSTIFSVERGYDDSKFDEDGRVKRTGTVTTASAHIITAVIGSGVLSLAWATAQLGWIAGPVAMMAFSCITWFTSILLADCYRSPDSVTGRRNRTYMEVVRANLGGLKVQLCGIAQYGNLVGITIGYTVTTAISMVAIKRSDCFHENHVRDGCHTSNNFFIILFGLIQVILSQIPNFHKLSLLSIIAAVMSFCYSSIGLGLSVAQIAGGAHPQTSLTGKPAGQSMTAMDKMWDTFSALGDIAFAYAFSTVLVEIQASRPIFLEDTLKSTPPENQVMKRAAFIGISVSTVFYMLCGVLGYSAFGNDSPGNLLTGFGFYEPFWLVDLANVCIAVHLVGAYQVFAQPIFAFVESWSKKKWPESTFINRENSIDLPGGCVTNFSPFRAPWGCLILAADGFLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP36</accession>
    <name>A0A068TP36_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014366001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP36"/>
    <dbReference type="FunCoup" id="A0A068TP36">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TP36"/>
    <dbReference type="Gramene" id="CDO97123">
        <property type="protein sequence ID" value="CDO97123"/>
        <property type="gene ID" value="GSCOC_T00014366001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP36"/>
    <dbReference type="OMA" id="HIFRTRC"/>
    <dbReference type="OrthoDB" id="1666376at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP36"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050655">
        <property type="entry name" value="Plant_B3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31920">
        <property type="entry name" value="B3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31920:SF122">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="254" mass="29551" checksum="876FB98D476DB8BC" modified="2014-10-01" version="1">MVNKSLGKDKDEIILDQRPAFFKIFNQLVENRLKIPPQFVRDVLIGIPKRIILETSYGSCWSVKVVKTDDGDVFLGDDWQKFVEDNLLQEHDFLLFHYDHGDRCFTVQIFDKSGVERTNQEVANSGTKNLDQHTTHVQPREKSQSREEGATLQEFCSQHPFFETNIKRYNVNPPFLMIIPKSFAEKHFQKAKTKIRLKNIEGKEWEVNYTINGGNFVFVGGWTRFVRDNKLKIGNVCIFELIGEKVLQVHISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPD5</accession>
    <name>A0A068TPD5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Beta-galactosidase</fullName>
            <ecNumber evidence="3 9">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00021850001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 9"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPD5"/>
    <dbReference type="FunCoup" id="A0A068TPD5">
        <property type="interactions" value="1011"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPD5"/>
    <dbReference type="Gramene" id="CDO97907">
        <property type="protein sequence ID" value="CDO97907"/>
        <property type="gene ID" value="GSCOC_T00021850001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPD5"/>
    <dbReference type="OMA" id="FWNIHEQ"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000021">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000115">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="13">
        <location>
            <begin position="103"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="14">
        <location>
            <begin position="475"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="15">
        <location>
            <begin position="637"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO97907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="726" mass="80977" checksum="F9DF82FA38AFD7A8" modified="2014-10-01" version="1">MKDRLPKRPGNVSLSSSSCTSGSRRPPPVAASAGGTVFKLLTMARKQSRRRTAIFILVICFAALGTLAPVFAPLPSSLSSRSNSHHNLKKSDGRSFEIADDKFWRDGEQFQIIGGDLHYFRVLPEYWEDRLLRAKALGLNTIQTYVPWNLHEPRQGELVFEGIADIISFLKLCHKLNLLVMLRAGPYICGEWDLGGFPAWLLAIEPALRLRSSDPPFLELVDSWWNILLPKMSPLLYTNGGPIIMVQIENEFGSYGNDKAYLHHLVNLARGHLGNDVILYTTDGGSRETLEKGTISGDAVFSAVDFTTGDDPRPIFALQKKFNEPGKSPPLSTEFYTGWLTHWGEKIASTSATFTADSLEKILSMNASVVLYMAHGGTNFGFYNGANSGADESDYKPDLTSYDYDAPISESGDVDNAKYKALQRVISKYTVEEPTSVPPDNQRATYGRIELQKSAFLFDIVDNPELISVVESEIPLSMESVGQMFGFVLYASEYNSKGNRSVLSIPKVHDRAQVFISCTSDDNRKRPIYIGTISRGSNRAIDLPHFSCVSRTKIYILVENMGRLNYGPYIFDKKGILSSVYVGGRPLFKWRMISIPFHNLNEGRKISSIVSDAYSKFIKASSLEDLNYRRHRDNLEPTFYTGRFAIDQVKDTYLSFNGWSKGIAFVNEFNIGRYWPSVGPQCNLYVPAPILREGENVVVILELESASSKLSLSSTDRPDFTCGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQJ2</accession>
    <name>A0A068TQJ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00022750001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate(in) + H(+)(in) = phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:29941"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQJ2"/>
    <dbReference type="FunCoup" id="A0A068TQJ2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQJ2"/>
    <dbReference type="Gramene" id="CDO98595">
        <property type="protein sequence ID" value="CDO98595"/>
        <property type="gene ID" value="GSCOC_T00022750001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQJ2"/>
    <dbReference type="OMA" id="DAYFNCF"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQJ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO98595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="550" mass="60474" checksum="20068880B46B3B82" modified="2014-10-01" version="1">MEEEKNELLELSSAEKGLCSSKSLGSEKLELTVDQVIEEYVGSFGFSQLLHVFLVSLAWIFDAQSTLVTIFADAQPDGWRCISSSSSSSCRLTNISSGDAASVCGLKPGTWEWMGGNTSSTIAEWGLICDRKFLAAMPASFYFLGSLVGASVYGYLADAFLGRKRAVLISCLLTSVTIFLTSLSPNIWLYSLLRFANGFSRSGIGICSLVLTTEVVGVKWRGQVGQYGFFFFAVGFVSIPLIAYPCRNSWRSLYKIISFLPLVYSIFVLLPFVSESPRWLLVRGRRKEALDVLRRYARLNGRKIPPNLCISEPSVATQETSKGEEVLQERTLWNTKWAAKRMALVMMTGFGIGFVYFGVQLNVENLNFNLYFAVAANAMMEISAVFIGGVLLSVAKRRLIFSQLAFIAGLSSILCILFSGGKQGILDKSGGSWPEFALEAIEFMAASTAFNVLFVYTVELFPTNVRSFAVSVLRQAMVLGASIAPLLVAVGRYSPALAFLIFGALSIFSGLMILWLPETRNSPLYETLEQQEQEGQLNSAPNHLETELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQV3</accession>
    <name>A0A068TQV3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00022385001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068TQV3">
        <property type="interactions" value="1921"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQV3"/>
    <dbReference type="Gramene" id="CDO98324">
        <property type="protein sequence ID" value="CDO98324"/>
        <property type="gene ID" value="GSCOC_T00022385001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQV3"/>
    <dbReference type="OMA" id="PTHYVEN"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQV3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000147">
        <property type="entry name" value="probable serine/threonine protein kinase IREH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058783">
        <property type="entry name" value="IREH1/IRE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26031">
        <property type="entry name" value="IREH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="886"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="1175"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="443"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1046"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1221"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDO98324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1297" mass="143004" checksum="D5D5623DDCE3EC96" modified="2014-10-01" version="1">MVFKGRFFSSKKSDTSSPDGSSNSPRSLGSNSPIRSDKKKVKSASISSKDNSPVSSGTSTSSSGFSKKDGRGKETLLKSSRGKDGKEVGPTPSAAAAVSMSPIVASSLGLNKIKTRSGPLPQESFLGFGSGREKGSALGASNLSKAFIGGGADSGSSLGSGKKSGGVKKDGGGGGEKKKLIGNIENAGWIDNGSNSDSMSTESGPSREQSPHVQAPSRLQNADSSTEAGRFNSSWDHSGGPRSSDVYTPDVKTSYECDNPKESESPRFQAILRLTSAPRKRFPGDIKSFSHELNSKGVRPFPFWKPRGLNNLEEVLGMIRARFDKAKEEVDADLHIFAADLIGVLEKNAENHPEWQETIEDLLVLARSCAMTPAGEFWLQCEGIVQELDDRRQELPMGVLKQLHTRMLFILTRCTRLLQFHKESGFAEDENTFQLRQSLQPADNRIPSATGMGGKVSSASKASKTSTTRKSYSQEQRGLEWKRDHDVKPGNLLLSPTDAAKNLDSPSRDRMASWKKFPSPVTKSPKEPVLLKEQDDSNVEATKILNNRRVLQDGDLATAKLPEVSSARDTQGHSSLPIKHQHKVSWGYWGDQPSVSDESSIICRICEEEVPTLHVEEHSRICAIADRCDQKGLSVNERLLRISETLEKLMESFSHKDFQHTVGSPDGVAAKVSNSSVTEESDMVSPKLSDWSRRGSEDMLDCFPEVDNSAFMEDLKGLPSMSCRTRFGPKSDQGMATSSAGSMTPRSPLMTPRTSQIDLLLGGKGAYSEHDDIPQMNELADIARCVANTPLDDERSLPYLLTCLEDLRVVIDRRKLDALTVETFGARIEKLIREKYLQLCELVDDDKVDISSTVIDEDVPLEDDVVRSLRTSPIHSNRDRTSIDDFEIIKPISRGAFGRVFLAKKRTTGDLFAIKVLKKADMIRKNAVESILAERDILITVRNPFVVRFFYSFTCRENLYLVMEYLNGGDLYSLLRNLGCLDEDVARVYIAEVVLALEYLHSMRIVHRDLKPDNLLIAHDGHIKLTDFGLSKVGLINSTDDLSGPAVSGTSLMEEDDSHISASDSQDRRKKRSAVGTPDYLAPEILLGMGHGFTADWWSVGVILFELIVGIPPFNAEHPQKIFDNILNRKIPWPRVPEEMSPEALDLIDQLMTEDPNQRLGARGASEVKQLPFFRDINWDTLARQKAAFVPASENAIDTSYFTSRYSWNPSDEHVYAASEFEDSSDNGSMSDISSCPSNRHDELGDECGGLTEFESNSSINYSFSNFSFKNLSQLASINYDLLTKGWKDDPPTNRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQZ3</accession>
    <name>A0A068TQZ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00021678001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQZ3"/>
    <dbReference type="FunCoup" id="A0A068TQZ3">
        <property type="interactions" value="3224"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQZ3"/>
    <dbReference type="Gramene" id="CDO97778">
        <property type="protein sequence ID" value="CDO97778"/>
        <property type="gene ID" value="GSCOC_T00021678001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQZ3"/>
    <dbReference type="OMA" id="TEAGMYC"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQZ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="205"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO97778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="430" mass="48038" checksum="E943F80E6074BEC9" modified="2014-10-01" version="1">MAPAASQDIEDEIKDEKNPRPLDEDDIALLKTYGLGPYSTSIKKAEKEIKEKAKVINDLCGIKESDTGLAAPSQWDLVSDKQMMQEEQPLQVARCTKIINPNTEDAKYVINVKQIAKFVVGLGDKVSPTDIEEGMRVGVDRNKYQIQIPLPPKIDPSVTMMTVEEKPDVTYNDVGGCKEQIEKMREVVELPMLHPEKFVKLGIDPPKGVLCYGPPGTGKTLLARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFQMARSKKACIVFFDEVDAIGGARFDDGVGGDNEVQRTMLEIVNQLDGFDARGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLESRTQIFKIHTRTMNCERDIRFELLARLCPNSTGADIRSVCTEAGMYAIRARRKTVTEKDFLDAVNKVIKGYQKFSATPKYMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS85</accession>
    <name>A0A068TS85_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00026140001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ELIP/psbS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS85"/>
    <dbReference type="FunCoup" id="A0A068TS85">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TS85"/>
    <dbReference type="Gramene" id="CDO99111">
        <property type="protein sequence ID" value="CDO99111"/>
        <property type="gene ID" value="GSCOC_T00026140001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS85"/>
    <dbReference type="OMA" id="VWPKDTE"/>
    <dbReference type="OrthoDB" id="513190at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS85"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO99111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="191" mass="20227" checksum="17740B9EFF267409" modified="2014-10-01" version="1">MAASVAMQSFLGSPVAGVSSRRGLNQVVRLSCGLHLPKRANFRVRSMAEENDKETADAAPQPTQPNVAQPNPAPKPKVSTKFEDVLAFSGPGPERINGRLAMIGFVAAIGVELGRGQDLFTQINDGGLQWFIGTSVLLSIASLIPLFRGVRAEAEGGGFMNSDAELWNGRFAMLGLIALAFTEYLKGGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT31</accession>
    <name>A0A068TT31_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026643001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068TT31"/>
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        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TT31"/>
    <dbReference type="Gramene" id="CDO99460">
        <property type="protein sequence ID" value="CDO99460"/>
        <property type="gene ID" value="GSCOC_T00026643001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TT31"/>
    <dbReference type="OMA" id="YCDINEN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052591">
        <property type="entry name" value="CML21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23064">
        <property type="entry name" value="TROPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="204" mass="23825" checksum="FE0FC7FD2CA728E8" modified="2014-10-01" version="1">MIEIKKSASGQSNFRSINSIIMKFPQFKEGLKEIRDIFQQYDEDNNATIEREELKKCSQELQLTIREEEIDDLFYYCDINENEGIQLNEFIVLLCLIYFLTDYSIPSHTASDILSPQLQATFNIIIEAFLFLDKKGKGKLNRKDVVQALNEASSLERSPSHVTHTRFKEMDWNRKGKVGFREFLFAFIDWVGMDSDDEAIEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT98</accession>
    <name>A0A068TT98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00029080001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TT98"/>
    <dbReference type="FunCoup" id="A0A068TT98">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TT98"/>
    <dbReference type="Gramene" id="CDO99486">
        <property type="protein sequence ID" value="CDO99486"/>
        <property type="gene ID" value="GSCOC_T00029080001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TT98"/>
    <dbReference type="OMA" id="HEKSTTV"/>
    <dbReference type="OrthoDB" id="2020306at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TT98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000001">
        <property type="entry name" value="NAC domain-containing protein 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044799">
        <property type="entry name" value="SOG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31079:SF20">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31079">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="8">
        <location>
            <begin position="65"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO99486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="314" mass="35089" checksum="13A351E8AF576455" modified="2014-10-01" version="1">MTWCSNESNQENLPLQIVPAQISHEKSTTVLNSKLNEVKTIACPSCGHPLEVQDQTGLLQDLPGLPAGVKFDPSDQEILEHLEARVLLDSRKIHPLIDEFIPTIEGENGICYTHPEKLPGVNKDGQIRHFFHRPSKAYTTGTRKRRKVHTDTEADGGGETRWHKTGKTRPVFISGALKGYKKILVLYTNYGRQRKPEKTNWVMHQYHLGTNEEEKDGELVVSKVFYQTQPRQCGGSSSISELDKRSTSSVSQSHLMKSTSNNFIDYYPHPYNISYNLGSQSGDSHSSSQLIPNLVVHGDGSSFIHLPSSVSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTJ8</accession>
    <name>A0A068TTJ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00026360001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTJ8"/>
    <dbReference type="STRING" id="49390.A0A068TTJ8"/>
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        <property type="protein sequence ID" value="CDO99269"/>
        <property type="gene ID" value="GSCOC_T00026360001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTJ8"/>
    <dbReference type="OMA" id="LMLIRWQ"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTJ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13113" checksum="5840A86F1DD952E0" modified="2014-10-01" version="1">MPDMQGLVNELIDKLKKRDGLINGLSFVLVLMLIRWQKGEGITGTALQTAELLRSVISVQKLPPTNKAAALINAVRDVGEKLIAANPVELSFGNVIRRVLHIVREEDLSPSSDEAGDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTY4</accession>
    <name>A0A068TTY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00029419001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTY4"/>
    <dbReference type="FunCoup" id="A0A068TTY4">
        <property type="interactions" value="1781"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTY4"/>
    <dbReference type="Gramene" id="CDO99740">
        <property type="protein sequence ID" value="CDO99740"/>
        <property type="gene ID" value="GSCOC_T00029419001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTY4"/>
    <dbReference type="OMA" id="QMFFPIP"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF8">
        <property type="entry name" value="PROTEIN REBELOTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="82996" checksum="2C1848E4448A7FD2" modified="2014-10-01" version="1">MGKLGKKARKFAKKNLQSVLRQRRKNKAFLSKKKSFSRDDQSPGKDKLDDTLDHSKGRNTDVEDVGDTSLDAVFTKDDSDMFADISDSDGYLSEDSSCPHVVGSEIGKSLEGNKLFSSLSTQNEKIHKDLAMQKKKLNRLRKKDPEFSKFLKNYKGIENSQNGNMYSDEDEESKKVIHLVDNNEAAEDKGKLFTSSAINLWCQLVKEEHSSSAFVCLLNAYRAACHYGAESLVHQIQNSETFCSILMFVLSEADDIFRRQLQISLVNCKKETILELQNTSKWQTIKPFVKSYFRSTLFLLDQVADSDILNFALNRLRASLIFFAVFPSLLHRLIKTTVHLWATGGGILSSTSFQIIRDVAALFSVDYFDTCIAKTFVAYMAQSRVSKILNNRHLLFLANCIVEICSLDVQNSSRKVLDSISQLSRILRWGLQTKKKEVLKKICSWEYANCIDLWVRFISVNIQDHDLQPLLFRIIQLINGVACMFTGPRYLPLRFKCIQWLNNLSTSSGIFIPVASYVLDVLEIDNVKEGGKLGDALDFSTVLRLPKSCLKSKTFQEECLSSAIEQLSFHFSQWSYHISFPELATIPLFYLRKFHDRTSAESLRRTVNRLIDQIEQNVNFVQKRRDEVVFSPKDHQSVETFLQLEKSGKNASFTQYYQSILERAALRSLYKENISSLKQKKSKRKRGQLIENSRDERSGADPALNAAAANGTAGFKGNERRTPKVKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV50</accession>
    <name>A0A068TV50_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00026239001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV50"/>
    <dbReference type="STRING" id="49390.A0A068TV50"/>
    <dbReference type="Gramene" id="CDO99183">
        <property type="protein sequence ID" value="CDO99183"/>
        <property type="gene ID" value="GSCOC_T00026239001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV50"/>
    <dbReference type="OMA" id="WMMRSIT"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000194">
        <property type="entry name" value="Cellulose synthase-like protein G2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13301">
        <property type="entry name" value="X-BOX TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO99183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84712" checksum="32E0E3A084599007" modified="2014-10-01" version="1">MEDSLPLNLCQVKKSSLVINRLYTSLHSIALLALIFYRTSTLLEITKTGNKSMPFVLFYVLVFASELMLSFIWLLNQAYLWRPVYRTVFPERLPEDDKLPAIDVFICTADPTREPSVQVMNTVISAMALDYPANKLHVYLSDDGGSPVTLGAMREAWNFARFWLPFCRKYGIKTSSPEAYFSVAGDGNVSSKEFTAEKEKIKEEYDVFKERVNKIKENATTIISKNHPSIIEVGEPDKAEMPLLVYVSREKRPSHPHNFKAGALNVLLRVSGLLSNSPHILALDCDMYCNDPASARQAMCFHLDSEISPKLAFVQFPHNFHNISDNDIYDSQLRTFFTLLLVNHSFKLRFNSSINQLIPLFNGMIQNQWYGMDGITGPINCGTCFYITREALCETSGSIQEDTNVGQLRKIFGPSNEFIKSLNRKIKSNIIKDEARCSSALLQESQLQVGFRYFSVVEDYFTGFLLHCKGWNSVYYNPQRPPFLGTASTNLGEMLVQNTRWTAGLIEVAISKYSPIIYGPSRMPILACMCYAQLAYYPFGFIPSWCLSIIPQLCLVQGIPLYPEISNPFFMVFVYLFLSSNLKHIQEALSAGHSIRTWMHEQRMWMIKSVTCYFYGSLNAIMEKIGMREASFLPTDKAEDEGRTKLYKSGMFDFRAPGMFIIPMCTLVILNIVSLLIGAVKIIHTRNYGEIFIQAFISFFIIVVQYPVIEGIFFRKDYGRIPKPASLLSTMLAGIILSLGSLVLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVA1</accession>
    <name>A0A068TVA1_COFCA</name>
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        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00000089001</name>
        <name evidence="3" type="ORF">GSCOC_T00026351001</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVA1"/>
    <dbReference type="Gramene" id="CDO99263">
        <property type="protein sequence ID" value="CDO99263"/>
        <property type="gene ID" value="GSCOC_T00026351001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP20148">
        <property type="protein sequence ID" value="CDP20148"/>
        <property type="gene ID" value="GSCOC_T00000089001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVA1"/>
    <dbReference type="OMA" id="CMIATNV"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007371647" evidence="2">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO99263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="79" mass="7781" checksum="0BD2EE3B4B47A658" modified="2014-10-01" version="1">MEPRGVLLLGFICVIVAGVGGQAPPSPPTTSPSPPTLTAPTTAPPAPPTPTASPLPTTNPPPTPTPTSSPPPVPYLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVE5</accession>
    <name>A0A068TVE5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">At1g61320/AtMIF1 LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032122001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVE5"/>
    <dbReference type="Gramene" id="CDP00240">
        <property type="protein sequence ID" value="CDP00240"/>
        <property type="gene ID" value="GSCOC_T00032122001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVE5"/>
    <dbReference type="PhylomeDB" id="A0A068TVE5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053772">
        <property type="entry name" value="At1g61320/At1g61330-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055357">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145:SF68">
        <property type="entry name" value="FBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145">
        <property type="entry name" value="OS02G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23622">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At1g61320/AtMIF1 LRR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="18213" checksum="4ABC9F84FCC6A23F" modified="2014-10-01" version="1">MVNYEEERSKYVNCFASRRDKDELTNIDRWIQFAAAKGVSRLEFNFSDEFVIHPRRQTRHLSEAERCYTSPTPITELMKLGRDLKQLASLRLRSVGLADEHVPCFLHNCPQLEELSIVHAPSLSDVKVVAAKVGHALRLKHLEISECKGLQHLEVVASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXN8</accession>
    <name>A0A068TXN8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pectinesterase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00032911001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXN8"/>
    <dbReference type="FunCoup" id="A0A068TXN8">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXN8"/>
    <dbReference type="Gramene" id="CDP00817">
        <property type="protein sequence ID" value="CDP00817"/>
        <property type="gene ID" value="GSCOC_T00032911001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXN8"/>
    <dbReference type="OMA" id="RFQMGNI"/>
    <dbReference type="OrthoDB" id="1430376at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXN8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046910">
        <property type="term" value="F:pectinesterase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000005">
        <property type="entry name" value="Pectin methylesterase inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051955">
        <property type="entry name" value="PME_Inhibitor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080">
        <property type="entry name" value="PECTINESTERASE INHIBITOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080:SF64">
        <property type="entry name" value="PLANT INVERTASE_PECTIN METHYLESTERASE INHIBITOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657412" description="Pectinesterase inhibitor domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="4">
        <location>
            <begin position="60"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="236" mass="25568" checksum="AB4AAF35897F3A83" modified="2014-10-01" version="1">MDTHQRPLFLITTFLLLLLHHPTSTHSLIDPTTYSTPAAAPTTTSAATPPATTTTYPTNKDTEFIRSSCASTRYPDECYNSLSGYASAVQQNPARLARVAIAVSLSRARLEATYFSNLSKEADYGADHRVSAAIHDCFSTFGDAVDQLRGSLNQMRHLVPAGSSETFRFQMSNVQTWMSAALTNEDTCTDGFDGVSDGPTKKDVFDRVHRAEAVTSNALALVNSYANTVAADSNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY97</accession>
    <name>A0A068TY97_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00032229001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY97"/>
    <dbReference type="STRING" id="49390.A0A068TY97"/>
    <dbReference type="Gramene" id="CDP00328">
        <property type="protein sequence ID" value="CDP00328"/>
        <property type="gene ID" value="GSCOC_T00032229001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY97"/>
    <dbReference type="OMA" id="HGHNTEA"/>
    <dbReference type="OrthoDB" id="2610923at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY97"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025525">
        <property type="entry name" value="hAT-like_transposase_RNase-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14372">
        <property type="entry name" value="hAT-like_RNase-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="748" mass="85068" checksum="598AEA12C07205F7" modified="2014-10-01" version="1">MARPLLTGLLTGLVLKKIDLICCLGFRHKHNMAMSPQDVSSQLVRSAGDSAGNNNEEELEYSIGDEELGSEEERLEGDTQAAAQTLNQEVGQGDDLDNFRRKKRAKKSAAWIDFKDVEVGFEKTLYSECLHCRVKFKKTKTGTTSSLLRHLKNCAERLKKVKRAEASQHKINFPAADSSSVAHSYLHTGKFDMAAMRESAAEWVLMHEHPFTIVEEDGFNIMMKRGMPEWQKITRTTNKNDCTSVYEREKTKLKNLLKKVKKISLTTDLWKSKNQKIEYMVITGHWIDTHWRLQKRVLNFVHVPPPRPGIAIADAIFKCLMDWGLETKVYTVSVDNASNNDTALRCLKDAFSRNKCLLAKGKLFHVRCCAHILNLLVQDGLSEIQDVVQAIRDSVEYINKTEGRRLIFAEIVKQLRLPGNALLYDCKTRWNSTYEMLAWALKFQEVFPRFKDREPSYDFCPTIEDWKNVEKVCNILQVFWTATHIISGSDYPTSNLYLNEVCRIKVLLDSKANDADYFVRTMVQRMKVKFDKYWGECNLLMSIAAILDPRCKMRVINYCFPLIYPPHEVQLNIDKVRQALYDLYAEYVEIHISGSSDAGASSQVVTNDSVNMTSSGSSSTITHVTGMSEFLSHIATVESVQPQKNELDTYFEDGLLTATEDSALDIVNLDALKWWKSTTKYKILPKMAADILAIPISTVASEATFSAGTRVIDSYRASLAPETVEMLMCAGDWCRKLHGIKKKEKVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U106</accession>
    <name>A0A068U106_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00039514001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U106"/>
    <dbReference type="STRING" id="49390.A0A068U106"/>
    <dbReference type="Gramene" id="CDP02195">
        <property type="protein sequence ID" value="CDP02195"/>
        <property type="gene ID" value="GSCOC_T00039514001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U106"/>
    <dbReference type="OMA" id="FAIKENF"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U106"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd03407">
        <property type="entry name" value="SPFH_like_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000013">
        <property type="entry name" value="Hypersensitive-induced response protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF34">
        <property type="entry name" value="HYPERSENSITIVE-INDUCED RESPONSE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP02195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="290" mass="31836" checksum="CF35D7A0741E2781" modified="2014-10-01" version="1">MGNLLCCAQVGQSTVAIKETFGKFDDVLEPGCHFLPWCLGSQIAGYLSLRLQQLDVRCETKTKDNVFVTVVASIQYRALADKASDAFYRLSNTRTQIQAYVFDVIRASVPKLNLDDAFEQKNEIAKAVEDELEKAMSAYGYEIVQTLIVDIEPDEHVKRAMNEINAAARLRVAANEKAEAEKIIQIKRAEGDAESKYLAGLGIARQRQAIVDGLRDSVLGFSVNVPGTTAKDVLDMVLVTQYFDTMKEIGATSKSSAVFIPHGPGAVRDVAEQIRNGLLQASAHQQPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U161</accession>
    <name>A0A068U161_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00034954001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U161"/>
    <dbReference type="Gramene" id="CDP01348">
        <property type="protein sequence ID" value="CDP01348"/>
        <property type="gene ID" value="GSCOC_T00034954001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U161"/>
    <dbReference type="OMA" id="NSHEAIC"/>
    <dbReference type="OrthoDB" id="1909330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U161"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044837">
        <property type="entry name" value="REM16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391:SF116">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS06G0194400-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS11G0197600-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="130"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP01348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="235" mass="27100" checksum="F305B1AC41015E36" modified="2014-10-01" version="1">MVKSKVKYEQLRQQRMEENKKKLEKLHLPLLSQALQKAALSPKTSPMKRVKPRTIRTELVPVRRSGRFTNKPAPQYKEVVFYERVQLPRSTVHPKRDLSNRVYASDEARAWAIEKAEKLESTLESGYPTLVKPMLQSHVTGGFWLGLPSHFSKRHLPKRDDTVTLVDEQGDKWRTIYLARKTGLSGGWKKFSVDHDLVDGDALVFQLIQPTVFKVHIIRENGFTEENSHEAICDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4F6</accession>
    <name>A0A068U4F6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039890001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4F6"/>
    <dbReference type="STRING" id="49390.A0A068U4F6"/>
    <dbReference type="Gramene" id="CDP02493">
        <property type="protein sequence ID" value="CDP02493"/>
        <property type="gene ID" value="GSCOC_T00039890001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4F6"/>
    <dbReference type="OMA" id="CREEAWL"/>
    <dbReference type="OrthoDB" id="641808at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4F6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF1">
        <property type="entry name" value="INSERTASE, PUTATIVE (DUF1685)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="176" mass="20005" checksum="CB0D45816AD10AD5" modified="2014-10-01" version="1">MSHNPTIPPSLSPPPTEFIPEPRRIQPVPTPSPSLYKQKSWSPDTYRDEAWQRRKGNHDIRCNRRSKSVTEEDLEELKACIELGFSFDSPKMDQRLSDTFPAYGLFYAVNKNYNDTVSKHITLASPFSSTVSDCDTPSPLDSPHNIFDPGENPQTVKTRLRQWAQVVACAVRQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4N2</accession>
    <name>A0A068U4N2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00039994001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4N2"/>
    <dbReference type="STRING" id="49390.A0A068U4N2"/>
    <dbReference type="Gramene" id="CDP02568">
        <property type="protein sequence ID" value="CDP02568"/>
        <property type="gene ID" value="GSCOC_T00039994001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4N2"/>
    <dbReference type="OMA" id="FITHHLF"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4N2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000020">
        <property type="entry name" value="Probable protein phosphatase 2C 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP02568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="381" mass="42239" checksum="D227AA3C4CF4E10F" modified="2014-10-01" version="1">MLGACYRPWESCLGGGRGGDGLLWHMDLKPHASGDYSIAVVQANSSLEDQGQVFTSPSATYIGVYDGHGGPQASRFITNRLFPFLQKFALEQGGLSEEVIKKAFNAIEEEFLHFVKSSWLSQPQIASVGSCCLVGAIANGVLYVANVGDSRAVLGKRVIGCPESNSSTVVAERLSTDHNVGIEEVRKEIEALHPDDAHIVVHTRGVWRIKGIIQVSRSIGDIYLKKPEFNRDPMFQQFGYPVPLKRAVMSAEPSILIRKLRPQDLFLIFASDGLWEQLTDEEAVEIVVKNPRIGIAKRLVRAALQEAAKKREMKYNDIKRLEKGARRHFHDDITVIVIYLDHQGSPTFRLKDTGIFDCTSVPVDIYSLNSDHADNTPQVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4P4</accession>
    <name>A0A068U4P4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041770001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4P4"/>
    <dbReference type="STRING" id="49390.A0A068U4P4"/>
    <dbReference type="Gramene" id="CDP03252">
        <property type="protein sequence ID" value="CDP03252"/>
        <property type="gene ID" value="GSCOC_T00041770001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4P4"/>
    <dbReference type="OMA" id="CCLNQER"/>
    <dbReference type="OrthoDB" id="1934410at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4P4"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654538" description="Phosphotransferase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="7">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="219" mass="24632" checksum="4E02AAC3B812DE68" modified="2014-10-01" version="1">MLWLLLSWVQGLMQHMSRGRMQFRSGMVCCLNQERWLSTWKWGNFRSSHLPLTEYDQGLDAESLNPGEQVNRALYSCFVFNKVLCRMAEEAAFFGDGVPPKLNIPFILRTPEMSAIHHDTSCDLKVVGAKLKDILEGTPGFYTFFPPLEDGEKQKSVVALDGGLFEHYTKFRNCMDSTLQELLGDAYENVSIIHSNDGSGIGAALLAASHSQYLEVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4Z5</accession>
    <name>A0A068U4Z5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00015998001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4Z5"/>
    <dbReference type="FunCoup" id="A0A068U4Z5">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4Z5"/>
    <dbReference type="Gramene" id="CDP03586">
        <property type="protein sequence ID" value="CDP03586"/>
        <property type="gene ID" value="GSCOC_T00015998001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4Z5"/>
    <dbReference type="OMA" id="GWLIMFQ"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4Z5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000043">
        <property type="entry name" value="sugar transporter ERD6-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF13">
        <property type="entry name" value="SUGAR TRANSPORTER ERD6-LIKE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="439" mass="46937" checksum="D410DB741A021CB9" modified="2014-10-01" version="1">MVYLSTFVAVCGAYEFGCCAGYSSPTQSAIREDLNLSISEYSLFGSILTFGAMIGAITSGPIADFVGRKGAMRLASGFCVAGWLAIYFSKGAVPLDIGRMATGYGMGVFSYVVPVFIAEIAPKDLRGALTTINQFMIVAGVSVSFIIGTLLAWRTLALVGLLPCAVLLLGLFMIPESPRWLAKGGRRREFEVALQKLRGSKADISEEAVEIQDYIETLERLPKAKIVDLFQRRYLRSVTIGVGLMVVQQLGGINGVCFYTSSIFETAGFNPDVGTITYAILQVVITGLGATLVDRAGRKPLLLVSGAGLVIGCLLTGISFYLKVHELALKTVPVLAVTGVLVYIGSFSAGMGAVPWVVMSEIFPINIKGVAGSLATLVNWFGAWLCSYTFNYLMTWSSPGTFILYAAINALGILFVTIVVPETKGRSLEQIQSAINASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5K9</accession>
    <name>A0A068U5K9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00016334001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5K9"/>
    <dbReference type="Gramene" id="CDP03840">
        <property type="protein sequence ID" value="CDP03840"/>
        <property type="gene ID" value="GSCOC_T00016334001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5K9"/>
    <dbReference type="OMA" id="NGHDSCF"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5K9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010078">
        <property type="term" value="P:maintenance of root meristem identity"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010082">
        <property type="term" value="P:regulation of root meristem growth"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010449">
        <property type="term" value="P:root meristem growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000276">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RCH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000333">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RCH1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.80.10.10:FF:002654">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RCH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000775">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000517">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase At1g34110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF5">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657632" description="Protein kinase domain-containing protein" evidence="23">
        <location>
            <begin position="38"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="788"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1093"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="817"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP03840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1147" mass="125032" checksum="98D413C7722272E6" modified="2014-10-01" version="1">MPMPRQMQSLNHQNHHHLQYCYLLLLLAVLSQAVAEAANNEVVVLFSWLQTSPSPPSSFSDWNSLDSNPCNWPYIKCSSDNFVTEINIQSIQLATPFPSNLSSLRSLRTLIISGANLTGTIPLEIGNCTSLRTIDISSNSLVGSIPITISKLQNLEDLTLHSNKLTGNIPPELSNCIGLKNILLFDNELSGNLPVELGKLASLVVLRVGGNKEIDGKIPDELGDCQNLVVLGLADTKISGSLPASLGMLRNLQVLSVYTTMLSGEIPSDIGNCSELVDLYLYENNLSGSLPAELGKLQKLQKMLLWQNNLVGHIPDEIGNCRSLLIADFSLNSFTGSIPWSFGNLTNLLELMISNNNISGSIPPVLSNATSLTQLQLDTNQISGSIPMELGFLTELNIFFAWQNKLEGSIPPGLAGCRSLQALDLSHNFLTGSLPPGIFQLKNLTKLLLISNDISGSIPHETGNCSSLMRLRLTDNKISGQIPSEIGLLRSLTFLDLSNNNLIGSIPDEIGNCLALQMLNLRNNTLSGTLPSSLSSLSRLQVLDVSLNTFSGRISGSYSQLTSLNRLVLSRNSFSGSIPSTLDRLTSLQLLDLSGNNLSGNIPMELFKIESLDIALNLSWNTLTGVIPPEISALNKLSVLDLSHNKLEGELMALSGLENLVSLNISYNNFTGYLPDNKLFRQLSATELAGNQGLCSLGHDSCFLSSGPGMGMPKTKDVRRSWKLKTAIALLAVLAVALAVLGFFAVFHVRTLKRKDNDYELGGGDISPWQFSPFQKLNFTVDQVLKCLVESNVIGKGCSGIVYRADLDNGEVIAVKKLWTSTMAVGYSRQNDQLGARGGIRDSFSTEVKTLGSIRHKNIVRFLGCCWNQNTKLLMYDYMPNGSLGSLLHERSSGCLEWELRYQIILGAAQGLAYLHHDCVPPIVHRDIKANNILIGLEFEPYIADFGLAKLVDDEDFARSSKTVAGSYGYIAPEYGYMMKITEKSDVYSYGVVVLEILTGKQPIDPTIPDGLHIVDWVRQKRAGAELLDPSLLSRPESEIEEMTQILGVAVLCVNPSPDDRPTMKDVAAMLKEIKHEKEEYMKVEMLLKDSQANEHKGTGKDNDKVYHGGGPSSTTMNSLCLESHNSSFTASSLLHSSSSSGKVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5X9</accession>
    <name>A0A068U5X9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016415001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5X9"/>
    <dbReference type="STRING" id="49390.A0A068U5X9"/>
    <dbReference type="Gramene" id="CDP03911">
        <property type="protein sequence ID" value="CDP03911"/>
        <property type="gene ID" value="GSCOC_T00016415001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5X9"/>
    <dbReference type="OMA" id="CGNIESP"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="106" mass="11173" checksum="818AF02B8589F6BE" modified="2014-10-01" version="1">MPIMKFSVGTELGNNRGRYQSGRVSGFRNEGVRGRGNYGGGRGYSRGDFGGRNEFNNRGGNRGVASNRGGDGYQRSDSNGGRMNRSGGGMANGTTKNMTPRVSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U897</accession>
    <name>A0A068U897_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00018727001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U897"/>
    <dbReference type="Gramene" id="CDP04676">
        <property type="protein sequence ID" value="CDP04676"/>
        <property type="gene ID" value="GSCOC_T00018727001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U897"/>
    <dbReference type="OMA" id="VATECIN"/>
    <dbReference type="OrthoDB" id="1727045at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U897"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP04676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="44086" checksum="352DC327333D082E" modified="2014-10-01" version="1">MGDRKGGFWYKELFPFTAMVATQCINVGVSIIFKAATLKGLDFRVFMLYSYCISALLFLPLCYFSHRKSQLPPLTIGLLGRFLFLGFLGFSGQYLGYIGIEYSNPTLASAMTNLTPASTFILAVLFRMEKLEMKSWTTQVKIIGSVITIAGALLVVLYNGPVLIRSSTSSASVLAQHPALVTIAGGTKHSDWVKGGALLAVEYVIVGLWCISQAKVIADYPAELAVVFFYNLSCLILAAPACLMGVTNSSAWNILKPDVRLYSVVYSGVMGSGFGILIQTWGVHIKGPVYIASFMPLSIAIAAIMGFIFLGDDLYLGSVIGSLIISLGFYALIWAKAKEDCEKGDEFGASSSQNAPLLGQYDDSTNEGRIISQTSPEVSHNYKKLHSNFKNYIYLPYFYCLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9M1</accession>
    <name>A0A068U9M1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RHOMBOID-like protein</fullName>
            <ecNumber evidence="9">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00020206001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="9"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9M1"/>
    <dbReference type="FunCoup" id="A0A068U9M1">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9M1"/>
    <dbReference type="Gramene" id="CDP05235">
        <property type="protein sequence ID" value="CDP05235"/>
        <property type="gene ID" value="GSCOC_T00020206001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9M1"/>
    <dbReference type="OMA" id="ELALIWH"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9M1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000019">
        <property type="entry name" value="RHOMBOID-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF86">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="107"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP05235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="321" mass="35250" checksum="3B890207CE81AD06" modified="2014-10-01" version="1">MAGEDIESGAGKNRGGGANYAIHAEERDTQWISWMIPVFIVANIAVFVMEMYVNNCPKHIGPGNKCVARFLGRFSFQPLSENPLLGPSASTLEKMGGLQWTKIVHQHQGWRLISSIWLHAGIIHLVSNVLCIALVGIRLEQQCGFVRIGAIYLLSGFGGSILSSLFIQNSISVGASGALFGLLGAMLSELITNWNIYTHKVAALLTILVIVIINLAVGILPHVDNFAHIGGFLTGFLLGFVLLPRPQLGWVGRHNLPADLRVKSKYKAYQYVLWLVSLVLLIAGLTVGLVMLFRGKNGYEHCHWCRYLTCVPTSKWKCDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA99</accession>
    <name>A0A068UA99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017979001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA99"/>
    <dbReference type="FunCoup" id="A0A068UA99">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UA99"/>
    <dbReference type="Gramene" id="CDP04548">
        <property type="protein sequence ID" value="CDP04548"/>
        <property type="gene ID" value="GSCOC_T00017979001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA99"/>
    <dbReference type="OMA" id="DWAIEPC"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd22674">
        <property type="entry name" value="FHA_PPP1R8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="427" mass="45893" checksum="CD83CFC77A6A0573" modified="2014-10-01" version="1">MYGRAGLDRFKKAQTSEPFSVSVSNSSANAKSPTQPSNKPLASPSASNSQHHLSQFHNQNPGSQKPLLPDVAQPVPPTQPVTQVGGGQSTWQPPDWAIEPCPGFYYLEVIKDGEVLDNIHLDKRRHIFGRQFQTCDFVLDHQSVSRQHAAVIPHKNGSIYVIDLGSAHGTFVANERLTKDSPVELEVGQSLRFAASTRTYILRKNNAALFPPPVHPSDINIPPPPDPSDEEAVVAYNTFLNRYGLGKPDESKSSDFDSSLQGKDERAAKRIRRTRVAFRDQVGGDLVEVVGVSDGIDVDTEPGPLGVKEGSLVGKYESLVQITVIPKGKEQSSSKEVGVSQAGVTEKLKQVLDKVKTPVRSGIYDDLFGESFSGKVGSSWAFSSAISGETQASPASEIEGTADAASGGELDSSLSAVDNEVDDDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBG2</accession>
    <name>A0A068UBG2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00021097001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBG2"/>
    <dbReference type="FunCoup" id="A0A068UBG2">
        <property type="interactions" value="2110"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05806">
        <property type="protein sequence ID" value="CDP05806"/>
        <property type="gene ID" value="GSCOC_T00021097001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBG2"/>
    <dbReference type="OMA" id="RENTNWI"/>
    <dbReference type="OrthoDB" id="515493at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBG2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11446">
        <property type="entry name" value="bHLH_AtILR3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000104">
        <property type="entry name" value="Transcription factor bHLH34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044818">
        <property type="entry name" value="ILR3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46133">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46133:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR ILR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP05806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="234" mass="25774" checksum="8C0C01901653060D" modified="2014-10-01" version="1">MVSPENTNWLYDYAFEDIAVPDGNFPASASGFNWPVQTLNGSSNVSVEIDGSLGDSDGPKETGSRKRLRTESCASTSSKACREKQRRDRLNDKFVELGALLDPGRPPKTDKAAILVDAVRIVTQLRTEAQKLKDSNLSLQEKIKELKAEKNELRDEKQRLKGEKEKLEQQLKTVNTQASFMPPPTMPAPFAAQGQAPGNKLVPIISYPGVAMWQFMPPAAVDTSQDHVLRPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCF0</accession>
    <name>A0A068UCF0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00021285001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCF0"/>
    <dbReference type="FunCoup" id="A0A068UCF0">
        <property type="interactions" value="2076"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCF0"/>
    <dbReference type="Gramene" id="CDP05957">
        <property type="protein sequence ID" value="CDP05957"/>
        <property type="gene ID" value="GSCOC_T00021285001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCF0"/>
    <dbReference type="OMA" id="VECKHIY"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCF0"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP05957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="249" mass="27822" checksum="B07F0B638DEADA5C" modified="2014-10-01" version="1">MASISAPHRSNAGGYSRMKSAASKLYNDNQSLIAEMRRAFNMMKEIAVDLEKDKKSDLVKELENGVAELLEASDDCMHLSTAILSVGNEYRPRQELTDFKKLLDDEITKSKATSSSTSQNHQFLRQFREAVWNVHHSGIPMPGEEQEDIVMTSTESNILNKTCPVTGKPVTELADPVRSMDCKHVYDKNAIMYHMRSMKSNCPCPVAGCPKELQVHRLICDPLLLVEIEEMRTMSKGAAQPGVIEDFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCP6</accession>
    <name>A0A068UCP6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00022926001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCP6"/>
    <dbReference type="FunCoup" id="A0A068UCP6">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCP6"/>
    <dbReference type="Gramene" id="CDP06226">
        <property type="protein sequence ID" value="CDP06226"/>
        <property type="gene ID" value="GSCOC_T00022926001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCP6"/>
    <dbReference type="OMA" id="QWPNAAM"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCP6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF15">
        <property type="entry name" value="SINGLE-STRANDED NUCLEIC ACID BINDING R3H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="216"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP06226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53007" checksum="3EDC77D9D6E76070" modified="2014-10-01" version="1">MHYTYNYIYRCILTDQVHIGFGFNKGFLIFILSLALSFSSFDAHQRAQSLFFLTPFYRRLPLLRPFRRPVKEFYLRERGASLAMDSNSSSLSSPPPAAADVAAGAQNGVVLVQKEKDKEAAAAPASAYLSMVDPFLVEALQNPRHRLTILRMELDIQKFLQNGDLQQFEFQHFPTSYLRLAAHRVAQHYGLLTMVKDNLVDGQGTRILVRKQAESKFPAVCLSDVPAKLSENDKNEQIKIVIRSRPTKASSNDSGEFGLKRSPVRTVEERKEEYDRARARIFSSQSSSESDDILTQVSSDGKNLCLGVEDNENLKNSVADFEKSFISREYSASSRVAIFRDREKDRTDPDYDRSYERYVKNVPMNQSFTLSPYVQKFQHPYVQYDSAFPQLGQMPGTQAPLSYTNPVMSPFCAMGLNQTSRDAVYMQWPSQSMMYAQSYDQFRHAVFQAPFCQQPLSFDYSQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDF2</accession>
    <name>A0A068UDF2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00022860001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDF2"/>
    <dbReference type="FunCoup" id="A0A068UDF2">
        <property type="interactions" value="1417"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDF2"/>
    <dbReference type="Gramene" id="CDP06189">
        <property type="protein sequence ID" value="CDP06189"/>
        <property type="gene ID" value="GSCOC_T00022860001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDF2"/>
    <dbReference type="OMA" id="GKECEIG"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDF2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001864">
        <property type="entry name" value="Calcium-dependent protein kinase SK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000085">
        <property type="entry name" value="CDPK-related kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000101">
        <property type="entry name" value="CDPK-related kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001294">
        <property type="entry name" value="CDPK-related kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="124"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP06189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="577" mass="64352" checksum="93965F413BC347F8" modified="2014-10-01" version="1">MGLCHGKPIEPPRHLSENPIIPSDNEPALSTTQTGKTPKFPFYSPSPLPSGFKNSPANSSVSSTPLRLFKRPFPPPSPAKHIRALLARRHGSVKPNEATIPEGSECEIGLDRSFGFAKNFVSHYELGEEVGRGHFGYTCSAKGKKGSLKGQDVAVKVIPKSKMTTAIAIEDVRREVKILRALTGHKNLVQFYESYEDEDNVYVVMELCKGGELLDRILSRGGKYSEEDAKAVMVQILSVVAYCHLQGVVHRDLKPENFLFTSKEEHSPLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRSYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVLKADPSFDEAPWPSLSADAVDFVKRLLNKDYRKRLTAAQALSHPWLAGHHDLKIPLDMIIFKLVKAYTCSSLLRKAALGALAKTLTIAQLTYLREQFTMLGPNKSGYVSVQNFKSAVTRMSTDAMKDSRVLEYVSLVSCLQYKKMDFEEFCAAAISVHQLEGMESWEQHARRAYELFEKDGNRPIMIEELASELGLSPSVPVHVVLQDWIRHSDGKLSFLGFVRLLHGVSSRTFQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEI6</accession>
    <name>A0A068UEI6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021395001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEI6"/>
    <dbReference type="Gramene" id="CDP06043">
        <property type="protein sequence ID" value="CDP06043"/>
        <property type="gene ID" value="GSCOC_T00021395001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEI6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8062" checksum="A712608F73DF53B0" modified="2014-10-01" version="1">MQQTATFSVMDVGFLIHPTHSTTHPHVPSYSVSLTAREMAGRTRSTSVTGGNLRAAGWQDSMAVISCRNLGEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG05</accession>
    <name>A0A068UG05_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00024783001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG05"/>
    <dbReference type="Gramene" id="CDP07505">
        <property type="protein sequence ID" value="CDP07505"/>
        <property type="gene ID" value="GSCOC_T00024783001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG05"/>
    <dbReference type="OMA" id="MNFNCCS"/>
    <dbReference type="OrthoDB" id="1549426at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055290">
        <property type="entry name" value="At3g26010-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546:SF66">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546">
        <property type="entry name" value="F-BOX PROTEIN INTERACTION DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43465" checksum="AF81BB53BC553670" modified="2014-10-01" version="1">MKEADRIELGNLCPEVVDSIFSRIPLKSLAKLKSVSKTRCNFIEHFRRRNPPTTASGLTIVLKNLNRNLHNPEFQESTFLRTQEGQQGFFSTRACIKGNFPVRLIDSCKGLLLYAANDGLSWAYYACSPFLDQCLALPRAHSITRLACASLALDGSSKENLRVLCFFLKEIDFVRGTVGCKIFSSATWDWREFQATILSTDLLLKRDFDVAHLFGPSVFCRGRLYWIWGLCMLVYDNEADFFKLIPLPSKAEEGNYGRPLDMLSQLLWESDGSIYFCYQMNERLCIYNFIGDDEVMDQEHEFYGTVNGEVKKLRAKCGIKPCGFNQDFHLLYLHVPPGTIVAYSLETRELEQVWACGEFKGNYAIEKILPFLFKSVNLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG29</accession>
    <name>A0A068UG29_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="11">dUTPase</shortName>
            <ecNumber evidence="4 11">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00024815001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4 11"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG29"/>
    <dbReference type="FunCoup" id="A0A068UG29">
        <property type="interactions" value="2330"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG29"/>
    <dbReference type="Gramene" id="CDP07530">
        <property type="protein sequence ID" value="CDP07530"/>
        <property type="gene ID" value="GSCOC_T00024815001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG29"/>
    <dbReference type="OMA" id="GREFHTQ"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG29"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="13">
        <location>
            <begin position="46"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP07530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="18721" checksum="6B0E050447904631" modified="2014-10-01" version="1">MAQDMSHQNHSPEVKEPTPKIQKLDRENCSIQQAAPFFRVKRLSDNAILPSRGSPLSAGYDLSSAAETKVPARGKALIPTDLSIAVPQGTYARIAPRSGLTWKNSIDVGAGVIDADYRGPVGVILFNHSDVDFEVKPGDRIAQLIVQKIVTPEVEEVDDLDATVRGSGGFGSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG77</accession>
    <name>A0A068UG77_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MLO</name>
        <name evidence="11" type="ORF">GSCOC_T00024487001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in modulation of pathogen defense and leaf cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MLO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG77"/>
    <dbReference type="STRING" id="49390.A0A068UG77"/>
    <dbReference type="Gramene" id="CDP07267">
        <property type="protein sequence ID" value="CDP07267"/>
        <property type="gene ID" value="GSCOC_T00024487001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG77"/>
    <dbReference type="OMA" id="EHEYEAS"/>
    <dbReference type="OrthoDB" id="1388414at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG77"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF53">
        <property type="entry name" value="MLO-LIKE PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4 8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="525" mass="58950" checksum="2ED7BD3D1E50A5D4" modified="2014-10-01" version="1">MAGDRAGRTLEKTPTWAVALVSAVIVVVSILLEKALHGIGKTFQRKRKEALNEALEKIKAELMVLGFISLILTFGQNYISKICIPLKVAETMLPCSHKDPEVEGEHHRRLLWNEHRFLAADSPATACKSEYVPVISVNGLHQLHIFIFFLAVFHVIFGAMTMTLGRLQTRGWKEWEREAVRETEASNDTSRFRLTHETSFVRDNTGSMARNPILFYPVCFYRQFFRSVRKADYMTMRHGFISVHLAPGSKFDFQKYIRRSLEDDFKIVVGISPTLWASAVIYLLLNVGGSQIMIWLSLMPLVTILAVGTKLQAIITQMAVEIQERHAVVQGIPLVQVSDRHFWFSRPHLILHLIHFTLFQNAFEITFLIWTTYEFGIHSCFYEGLELSILRVVMGVAVQVLCSYITLPLYALVTQMGSHIKKSIFDEQTKKALTKWTLNAKKKNNVKPGTPQKQRLGGSPVESPEDSPKLAAGPSSTSGLEMSGLELRKPHGQHSSAANITASVDIPDPPHTPPPNDVGDLLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHM6</accession>
    <name>A0A068UHM6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00025549001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHM6"/>
    <dbReference type="STRING" id="49390.A0A068UHM6"/>
    <dbReference type="Gramene" id="CDP07986">
        <property type="protein sequence ID" value="CDP07986"/>
        <property type="gene ID" value="GSCOC_T00025549001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHM6"/>
    <dbReference type="OMA" id="PARICDH"/>
    <dbReference type="OrthoDB" id="1743210at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654811" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="11">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="310" mass="33938" checksum="6F8C63DC49AA5EA1" modified="2014-10-01" version="1">MEKAHFLFLVALVASLATASSSTTNVVARNNTNDHDLDALLAFKAAISDPQNILPTNWSTSTSVCNWIGITCNRRHRRVAAIQLPKMGLVGTIPPQLGNLSFLVWLDLENNSFHGNLPTQMVHLRRLKYFNLAFNSFDGSLPTTLSNATMLETIRFGTNLITGYLPQDWSALQNLEFLDMENNQLDGPLPRSLFNVSSLQIFSFTNNTLSGYLPARICDHLPQLKGLYLSNNEFSGAVPAGIGGCPRLQVLSLSYNNLAGNIPKEISNLTMLRVVFLAPNDVQGQIPADIGNLTNLEQLGIEVANLTGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI71</accession>
    <name>A0A068UI71_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00026908001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI71"/>
    <dbReference type="STRING" id="49390.A0A068UI71"/>
    <dbReference type="Gramene" id="CDP08161">
        <property type="protein sequence ID" value="CDP08161"/>
        <property type="gene ID" value="GSCOC_T00026908001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI71"/>
    <dbReference type="OMA" id="CEANILM"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI71"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11538" checksum="5372493A3A28403D" modified="2014-10-01" version="1">MGADLFWAIRGAGGACFGVIVAWKIKLVHVPPVVSVFTISKALEQAAIDLIHKWQYLGHKLSEDLLLSIVKTSGNDGTIQATFNSLLLGKADHLLNMIDDSFPEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKX3</accession>
    <name>A0A068UKX3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrochelatase</fullName>
            <ecNumber evidence="9">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00027005001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Plastid</location>
            <location evidence="1 9">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="9"/>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKX3"/>
    <dbReference type="FunCoup" id="A0A068UKX3">
        <property type="interactions" value="2243"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKX3"/>
    <dbReference type="Gramene" id="CDP08238">
        <property type="protein sequence ID" value="CDP08238"/>
        <property type="gene ID" value="GSCOC_T00027005001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKX3"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKX3"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000006">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF4">
        <property type="entry name" value="FERROCHELATASE-1, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0934">Plastid</keyword>
    <keyword evidence="7 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP08238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="491" mass="54256" checksum="BB2EB2088FEB3580" modified="2014-10-01" version="1">MNATAVSGGVLPQMMQPISNLETFTNNNSSLVCSRNGVRAPSFKASHDGKQIYCQSNEASATQSCGSTAQKSNVLGGLSLKSHRQTVGKTFCSAGEYAYSGGAINYQSRTAEEKVGVLLLNLGGPETLHDVQPFLYNLFADPDIIRLPRLFKFLQRPLAQLISILRAPKSKEGYAAIGGGSPLRKITDEQANALKMALEVKKVPANVYVAMRYWHPFTEEAVHRIKTDGITRLVVLPLYPQFSISTTGSSIRVLQSMFRNDAHLSSLPVAVIESWYQRDGYVRSMADLIEKELANFSEPEEVMIFFSAHGVPVSYIEDAGDPYKDQMEECILLIMQELKARGTKNNHTLAYQSRVGPVQWLKPYTDEVLVELGQKGVRSLLAVPVSFVSEHIETLEEIDMEYKHLALESGISNWGRVPALNCTPSFINDLADAVIEALPSAMAMSTSDTASEDELYDDPMRYVIRLFFGSILAFLLLLSPKAILAFRNNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL66</accession>
    <name>A0A068UL66_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027163001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL66"/>
    <dbReference type="STRING" id="49390.A0A068UL66"/>
    <dbReference type="Gramene" id="CDP08358">
        <property type="protein sequence ID" value="CDP08358"/>
        <property type="gene ID" value="GSCOC_T00027163001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL66"/>
    <dbReference type="OMA" id="LAWHESH"/>
    <dbReference type="OrthoDB" id="759788at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34189:SF13">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18032" checksum="AB6D8EDEF9583C97" modified="2014-10-01" version="1">MYRSSSSARVSEEFFSNSSSSSAAAAAGAMSSTNHKPATTTSDLDHLPTYNPMSHLAKKEKSRLRSVENSIHLIPVLLVLCAIVLWFFSSPVDLVNKSDSVVARIESSLIKSGVDRGHGKSSLESTLKQEDLNPANQSTEGVDPVNQSADDEVLDNQSTGSAEHNTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL72</accession>
    <name>A0A068UL72_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027169001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL72"/>
    <dbReference type="Gramene" id="CDP08363">
        <property type="protein sequence ID" value="CDP08363"/>
        <property type="gene ID" value="GSCOC_T00027169001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL72"/>
    <dbReference type="OMA" id="TLMFHDS"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF5">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="344" mass="39835" checksum="7F665C6BE2B40A59" modified="2014-10-01" version="1">MIRAWNMPEECESRKFNRIQTRGNASDSYDDACMICADGGNLMCCEVCNSTYHQDCIQLKEVPRGSWYCPYCVCRFCRNPAHDNDYLIECPQCEQKYHWNCHLRREMKIIDLNSMPCAPFCEGRCKEVYDKLERHLVGLKNELDEGFSWSLLHHMDNDTGSYTDDTYKRIVCHSKLAVALRLMEDCFEPIVDRHTRINVIRSVVYNCGANFKRIQFRGFYTALLEKDDEIISVASLRIHGTKLAEMPFIATSDQYRCKGMCKKLMVAIESALCYLNVESLVIPSTSERISNWIEKYGFRLLDSTLNREIICRNTLMFHDSVRLQKSLVPSCLAKSDRSSGGMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULN5</accession>
    <name>A0A068ULN5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028835001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULN5"/>
    <dbReference type="FunCoup" id="A0A068ULN5">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULN5"/>
    <dbReference type="Gramene" id="CDP09460">
        <property type="protein sequence ID" value="CDP09460"/>
        <property type="gene ID" value="GSCOC_T00028835001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULN5"/>
    <dbReference type="OMA" id="KIRAFCT"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULN5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012398">
        <property type="entry name" value="PRIB5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015897">
        <property type="entry name" value="PRIB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="255" mass="28061" checksum="5621A83DE6582A24" modified="2014-10-01" version="1">MRHGDRLDNFDLLWASKASRPWDPPLTQDGKDRAFARGRKFRAGRSPVNFPIHRVFVSPFLRCLQTATEVVHGLCAVNDDDLTVTSSNGITIDPSKIKVAVEYGLCEMLNATAVRPENVPKDYDFGFDISKCEAVLPAGTIDHSVEPVDKEIPQWGELPADARIRYCSVIKELADKYPSENLLLVTHGEGVGSSVTAFAENTQVYAADYCGYSHLSRSVFPAEDESFTAGPFKVHIKDGENGLSYCGSSVERDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMN2</accession>
    <name>A0A068UMN2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028985001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMN2"/>
    <dbReference type="STRING" id="49390.A0A068UMN2"/>
    <dbReference type="Gramene" id="CDP09562">
        <property type="protein sequence ID" value="CDP09562"/>
        <property type="gene ID" value="GSCOC_T00028985001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMN2"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMN2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="103" mass="11962" checksum="7DD9D7C2A305A3A9" modified="2014-10-01" version="1" fragment="single">EPNDEVDYEEDEVNNIDDDIDEEDFDAYEAIDPIGFQEGVFSPQQDSYTDHENMSRNYLQELFGSFPFNAAGDNEMPDANISDGEYEIYEHYSDENYSNDDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNY5</accession>
    <name>A0A068UNY5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030759001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNY5"/>
    <dbReference type="STRING" id="49390.A0A068UNY5"/>
    <dbReference type="Gramene" id="CDP10141">
        <property type="protein sequence ID" value="CDP10141"/>
        <property type="gene ID" value="GSCOC_T00030759001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNY5"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45376">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45376:SF1">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="220" mass="25259" checksum="F20C9F1C750EED7C" modified="2014-10-01" version="1">MNKNKLFLLKPAALAVLNSTRFRLNSTNQKPFLFHSTPALSSRRRPYYYSSEGVYRAPKRRYKNFVRGFSNPLWKRILLRDPSAPSNGPVQNDYYYYTPYSSQSSSWFGQDYQATRSNAFGGSNSNHHWSSWNWRNQNQGKDDPPKKSDNSTPEMTSERLALGLSASGPLTLEEVKNAYHACAMKWHPDHNQGLFKTVAEEKFKSCKAAYESLCDYVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP12</accession>
    <name>A0A068UP12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00030632001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739126">
        <property type="protein sequence ID" value="CDP10052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP12"/>
    <dbReference type="FunCoup" id="A0A068UP12">
        <property type="interactions" value="2407"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UP12"/>
    <dbReference type="Gramene" id="CDP10052">
        <property type="protein sequence ID" value="CDP10052"/>
        <property type="gene ID" value="GSCOC_T00030632001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP12"/>
    <dbReference type="OMA" id="ADEAWND"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UP12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000539">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000304">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF10">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="12">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="425"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1238" mass="139407" checksum="743E5963435555A8" modified="2014-10-01" version="1">MGHSSKKKKKRGGARRAPSKDHNSLAADNSELIGEEITALCAIFQDECEVVSGSPPQIQIKLRPYSKDTGYDESDISALLSVRFLSGYPNKCPKLRIIPEKGLSVVDVDNLLSLLHDQANSNAREGRVMIYNLVEAAQEFLSEVVPQAESREAAISQATDRSTLLSRKDLAVSRIMMYSCKGPFVYGYIDLFSGCGESWHWSLGMEQNSGLKTEVSSNTFEHSKVGHQNADNKIGKKSVELQGAKQEFAQNPALKLVTVKEESEDEIKSTDSSTTLSCGTVKSGSVGNIKDIFVEENLAETTDEDRLIEPSESVSSKSVINHQLSQTMRTDLIMVHLLRLVCAPKGPLGDALLQITSELYNLGIVSEHVRDLTIEPSPVFEKAFNHVFAQHRVSSKISQFWRTASDFEVQNSSSTSSSRYLSDFEELQPLAGHGGFGHVVLCKNKIDGRQYAVKKIRLKDKSLPINDRILREVATLSRLQHQHVVRYYQAWFETGIAGSFDATQGSKATMSSTFSYMDGSSSDIFGLETKLDSTYLYIQMEYCPRTLHQMFEPYNHFDKELAWHLFRQIVEGLAHIHGQGIIHRDLTPNNIFFDARNDIKIGDFGLAKFLKLEQVEQDVDATETVGVSVDGTGQVGTYFYTAPEIEQGWPKINEKADMYSLGVVFFELWHPFDTAMERHIVLSDLKQKGELPSAWLADFPEQASLLRLLMSPSPSERPSATELLQHAFPPRMEYELLDNILRTIHTSEDTGVYDKIVNAIFDEELLSTKEHESVERLKLLGGDISSVLFSDVDTSNRDHVLEVAAGVFRQHCAKHLEVIPMHMLADSRQLNRNTVKLLTNGGDMVELCHELRLPFANWIIANQKSFFKRYEISYVYRRAIGHSPPNRYLQADFDIVGGAIALTEAEIIKASMDIIGQFFHSELCDIHLNHGDLLEAIWSWAGIEPEHRQKVAELLSLLGSLRPQSSERKSKWVVIRRQLQQELNLAEAVVNRLQTVGLRFCGLVDQALPRLRGALPAGKSTRKALDELSELYNYLRVWRLDRHIFVDALMPPTENYHRNIFFQIYMRKSLGSLVEGTLLAVGGRYDYLLHHTGDFEYKSNPPGAVGTSLALETILSHSSMMDTKIYRHDVGIEVLVCSRGGGGLLVERMELVAELWQQNIKTQFVPICDPSLTEQYEYANEHDIKCLVIITDSGVSQTDSVKVRHLELKKEKEVPREELVKFLSEAMATQFKNPSIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPR8</accession>
    <name>A0A068UPR8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030868001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPR8"/>
    <dbReference type="FunCoup" id="A0A068UPR8">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPR8"/>
    <dbReference type="Gramene" id="CDP10214">
        <property type="protein sequence ID" value="CDP10214"/>
        <property type="gene ID" value="GSCOC_T00030868001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPR8"/>
    <dbReference type="OMA" id="PENLHYP"/>
    <dbReference type="OrthoDB" id="2020857at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPR8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080147">
        <property type="term" value="P:root hair cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000017">
        <property type="entry name" value="Transcription factor bHLH66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF327">
        <property type="entry name" value="TRANSCRIPTION FACTOR LRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="226"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="447" mass="46371" checksum="7A41ABCB9B393743" modified="2014-10-01" version="1">MQAMNSLLNQQLHDLQNGQQQQHHHHFDSTTSSHDDFLEQMLSSISTASWPAPDLIKTQPPWDPLSQTPLGSLEDQSVLLANKLRQHQIGGAKALMLHQQLMLPRGLAGNGLRSPPGPNGGLLAMPPLNLAGNGDQNEVIVDGSPFKSANPGNDASVQALYNGFTGQASTQPQHFHHPQGGAMQAQNFGAQAMNQAAASGSMGTAGGGGTAAAQPRQQRVRARRGQATDPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSMSRLGGAVAPLAADMSSEGGGDCGNGRSSNGTQTASSSNNNNNDGMTVTEHQVAKLMEEDMGSAMQYLQGKGLCLMPISLATAISTATCHSRNPMHPGLTGNGANNPLLGLGGGASGNGVGEAGGPSSPSMSVLTVQSATMVNGGGGPGGEPSSVKDAASVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR94</accession>
    <name>A0A068UR94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00031585001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739131">
        <property type="protein sequence ID" value="CDP10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR94"/>
    <dbReference type="FunCoup" id="A0A068UR94">
        <property type="interactions" value="2687"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UR94"/>
    <dbReference type="Gramene" id="CDP10759">
        <property type="protein sequence ID" value="CDP10759"/>
        <property type="gene ID" value="GSCOC_T00031585001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR94"/>
    <dbReference type="OMA" id="WQLEADH"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR94"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36710" checksum="014490411812EA08" modified="2014-10-01" version="1">MADSGEAPQQKQEVCNFFKKPSKGKNIRKRPAVDEDNADEDSKDESSVIFNKKKPAAADNKLHFSTGSSKRSIEAETNADSKTPFFHFESSKEIQVHNDSRATATLETETEFSRDARAIRERVLKQAEEALQGKGTSDEKVYKGMHGYTDYKAGFRREHTVSGEKAGGSHGPLRASAHIRVSARFDYQPDICKDYKETGYCGYGDACKFMHDRGDYKSGWQLEKEWDEAEKIRKRNLALGIDNADEDTAEKSDEDEDDALPFACFICRQPFVDPVVTKCKHYFCEHCALKHHARNKKCFVCNQPTMGIFNTAFEIRKRMSAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URR1</accession>
    <name>A0A068URR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00031944001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URR1"/>
    <dbReference type="STRING" id="49390.A0A068URR1"/>
    <dbReference type="Gramene" id="CDP10959">
        <property type="protein sequence ID" value="CDP10959"/>
        <property type="gene ID" value="GSCOC_T00031944001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URR1"/>
    <dbReference type="OMA" id="VCQVLFQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000003">
        <property type="entry name" value="ABC transporter C family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000169">
        <property type="entry name" value="ABC transporter C family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000002">
        <property type="entry name" value="ABC transporter C family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF222">
        <property type="entry name" value="OS01G0902100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="115"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="375"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="659"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="972"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136064" checksum="1EF365B7870EABA9" modified="2014-10-01" version="1">MMKIVLPKILSYFNALLSRNSREQCNDGEEPFLKSADEDAFSTAGIWSKLGFLWLNPLFKKGHLERLEFQHVPTISQSEAAAEAFSSLEESLGKQNPNKTSLWKAILHTLWRPLALNAIFAGANTISSYIGPLLITTFVKFLSEKDDASENWHQGLVIPLIFFSAKTVESMSQRQWYFGAHRIVIRLRAALMVLIYKKSLSVKYVGMSTGKIINLIDGDVERVGDLCWHIHEIWLLPVQVTLALVILYWNLGAVPSFAALLTTILVMLTNTPLAKVQKQFHTKIMEAKDSRIRATSETLKSMRVLKLQSWESTFLERLLQLRGIERSWVKKYLYTCSAVAFLFWASPTLISVVTFGDDENLPIGDPAPNSSGVAVKIEAAEYAWGTDDAKKATITITDKIRIMKGHTVVICGSVGSGKSSLLFSILGEIPRISGASVKTCGTKAFVPQSAWIQTGTIQDNVLFGKEMDRDFYEEVVRACALNKDFEIWLDGDLSRVGERGINLSGGQKQRIQLARAIYSDSDIECIEKLLATKTVIYVTHQLEFLDAADLVLVVKDGKIVQSGNYHDLIADPDSELNRQIAAHTKTLDEVTTVQQFNRSPKDNHQDNQNEITGKKFKDFNMNSRLLEKNQQEEAKYGRVKWHVYSTFITSGYKGMLVPIILLCHILFYGLQIASNYWIAWATEEEGRVSSVRLIGIFALLSAGSSLFILGRAILLSTAAIETSQRLFLGMITSIFRAPLSFFDSTPSSRILSRSSTDQSTVDTDLPYRVAGLAFAVIQLLSVIVLMSHVAWQVIFPFLIILAISIWYQDYYISTARELARMVGIQKAPILHHLSESVAGAATIRCFNQEDRFLKKNLDLIDNYSRVAFYNSATMEWLSIRINFLFNLVFFLLLLILVNLPRSAIDPSLAGLAATYGLSLNVLQAWVIWNLCNVENKMICVERILQFTNIPSEAPLVIEDCRPQPAWPLHGKIEIENLHVQYSPSLPKVLKGINCTFPAEKKIGIVGRTGSGKSTLIQALFRVVEPSDGRIMIDGLDICKIGLQDLRSKLSIIPQDPTLFQGTIRSNVDPLQQYPDHDIWEVLRKCHLAEIVMLDQRLLDAPVAESGENWSVGQRQLVCLARALLQKRRVLVLDEATSSVDTRTDNVIQKTIREETSQCTVLTVAHRIPTVIDNDIVLVLGEGKIVEYDTPARLLDNKYSAFSELVTEFLRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USA5</accession>
    <name>A0A068USA5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033667001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USA5"/>
    <dbReference type="Gramene" id="CDP11420">
        <property type="protein sequence ID" value="CDP11420"/>
        <property type="gene ID" value="GSCOC_T00033667001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USA5"/>
    <dbReference type="OrthoDB" id="1916794at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USA5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33621">
        <property type="entry name" value="ASPARTIC/GLUTAMIC ACID-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33621:SF2">
        <property type="entry name" value="RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="560" mass="63449" checksum="21A985F366207367" modified="2014-10-01" version="1">MDFHNLKRRELQELCKKHKIPANLTNLEMATKLTALLRGNQQPLTRGLRSCLKGLEENVSENESDFENRPAKKVRFSPQNEMIEFEKSAVKCMETRVRGRRKSVMNHSKGGEVVENDSPVILVDEGVGRGRRSRRGKVIEGSCVKRKGGKMGVEDNVLKDKLPSASGVVGMSSDAPMDEGAGRVTRSRKVKFMEDREVESKGGKKGMKADALKGELPSATADNVPLVDFSNEEHVVVGKRSLRNRVIDVEKKKIALVEKGSQQNEEDLLVRKRSLRNIELKDNKMRAYEDVEKGSRKTERQVKDMRRKDIVRTKATEEEPEAIQAEKVLRRSRRHVAKMECHKLVKEDVRKIEKAVQGRLRSIVAVEVKEVSEVDSVSGMMKESYPFDDNLRRSKRNAAKPEVIYTREQTDKVANAKGKEESKKRRRDAFLQEQAVKVDGNSVERPLRRSTRNTEKIERVAATTVRGKVAQKQKGKSKKTRGKFEDSFTEEILITEDLLAPEAELMIPEIVKDTVIDNFNVVVDLTGYVSDLNGADTSEPNFIGEGRGIVYFPLFVLFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USB1</accession>
    <name>A0A068USB1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00033186001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USB1"/>
    <dbReference type="FunCoup" id="A0A068USB1">
        <property type="interactions" value="1979"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USB1"/>
    <dbReference type="Gramene" id="CDP11134">
        <property type="protein sequence ID" value="CDP11134"/>
        <property type="gene ID" value="GSCOC_T00033186001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USB1"/>
    <dbReference type="OMA" id="ECFCQPN"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USB1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF14">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="518" mass="58508" checksum="46C98FC097A99951" modified="2014-10-01" version="1">MRRHGHRYQHLLKQSNGGVKGMFGKLAIAAVVLVICMVSLVSTLKSSSSSPSRSEINVDTLWENAPSGGWRASSAPRSDWPTPSKQTNGYLRVRCNGGLNQQRSAICNAVLAARIMNATLVLPELDANSFWHDDSGFQGIYDVEHFIKTLKYDVNIVERIPEISKNGKTRKLKAFKLEPPRDAPISWYTSKALEKMKEHGAIYLTPFSHRLAEEIDKPEYQRLRCRVNYHALRFKPHIMELSKSIVDRLRAQGHFMAIHLRFEMDMLAFAGCYDIFTPKEQEILKKYRKENFAEKKLIYEQRRAIGKCPLTPEEVGLILRAMGFNNTTRIYIASGELFGGERFMGPFQSMFPRLENHSTIDTTGELAKNTRGLVGSAVDYMVCLLADIFMPTYDGPSNFANNLMGHRLYYNFRTTIWPDRKALTPVFIARENGHTAGFEEAIRRVMLNTNFGGPHKRISPESFYTNSWPECFCQTPAQNPADGCPPKNISDILESQLQSSGVTDDGFVGSDVASVTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USE5</accession>
    <name>A0A068USE5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00033282001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USE5"/>
    <dbReference type="FunCoup" id="A0A068USE5">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USE5"/>
    <dbReference type="Gramene" id="CDP11192">
        <property type="protein sequence ID" value="CDP11192"/>
        <property type="gene ID" value="GSCOC_T00033282001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USE5"/>
    <dbReference type="OMA" id="RAIECEA"/>
    <dbReference type="OrthoDB" id="672127at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USE5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF20">
        <property type="entry name" value="DUF247 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="440" mass="51013" checksum="C733E9179D6C74E2" modified="2014-10-01" version="1">MEDQEKVVIVVDPGSEVKISVNTSKPNPPGQVELPRVPEKQRRKNEEAYTPRLVSIGPLHHGDAQLKAMEEYKLKYLNNFLHTFKIPLELLAEYAHSQEKNVCGCYEDTYIRDLSKLSEVILFDGIFIIELFLKNYFPEMREMGDTIFENRWVSSDIMHDLLLLENQLPMRFIATMYNGFVSRKLSKFLDNDSDDPPSFDKLAFEYLKNVGNTQKLESKMDHTFPRARHLVEFLAVLHWPSDQKAKREEVKKVEFGKCATATKLRAAGVKFSHRAEKCLFDVRFEKGELVIPQLTVNDFTETFYRNLIAFEQCGYHYKDITSYVILMDNLIDTPKDVDLLIKHKIIVNELGSSEQVADVFNNLYKEIVTDPKEFYFANLCNQLNEYSRDWVHKMVTKLAVWYTMLCNDYFGSPWSIISVIAAIILLVLTVIQTVCSVLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USL2</accession>
    <name>A0A068USL2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00033294001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USL2"/>
    <dbReference type="STRING" id="49390.A0A068USL2"/>
    <dbReference type="Gramene" id="CDP11199">
        <property type="protein sequence ID" value="CDP11199"/>
        <property type="gene ID" value="GSCOC_T00033294001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USL2"/>
    <dbReference type="OMA" id="QDACIDA"/>
    <dbReference type="PhylomeDB" id="A0A068USL2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000445">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000719">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF95">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="401"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="678" mass="75778" checksum="2CD57F2BD25C16D4" modified="2014-10-01" version="1">MPHFVVHANKQTCSEILIGTIPTSLGNLTNLTVLHLYDNQLSGSIPEELGNLELLTDLELDRNELNGSIPKSFGDLSNLEFVFFRENQLSGSIPEELGKLAKLAVMEMDTNQFSGHLPEHLCQNGTLQNFTVSNNNLIGPIPISLKICSSLFRARFQGNRLTGNLSEMFALLLADNHITGQIPSEVGNAYQLHVLDLSSNDFTGEIPKQVMMLASMLNLYLQNNQLFGNIPEEVGQLKIYFILTCQQISCIPPQMGELTRLSILDLSHNYITGEIPSEFRSLQSLEVLDLSHNYLSGFLPKALAELPGSLHINISFNNFEGPIPYGKAFNNITIEELRGNKVVLPLLGSLLLLCAFFGALKVRRQRKRKTTENVEDADLFSITTYDVKAMYREIIKATEEFSEIFCIGEGGFGSVYKTILPPSNLVAVKRLHLLPEKVYFDSFLNEIRALTNIKHRNIVKLYGFCSNSKHSFLVYEYLERGSLAKIFSADEEAKELDWEKRVNIIKAVAHALSYMHHDCTPSIVHRDISSNNVLLDSEYEARLSDFGTAKFLKKDSSNWTTLGGTLGYVAPELAYTMRVTEKCDVYSFGILTLETIKGTHPGDIVANLMSSTPGNIELKDLLDQRLLHPTEETEKILISTIKLAKPCLHVNLDSRPTMHMISSLLSVGAPCRQQVGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT21</accession>
    <name>A0A068UT21_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">12-oxophytodienoate reductase</fullName>
            <ecNumber evidence="9">1.3.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00031560001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(1S,2S)-OPC-8 + NADP(+) = (9S,13S,15Z)-12-oxophyto-10,15-dienoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57411"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:191855"/>
            <dbReference type="EC" id="1.3.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; oxylipin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.42" evidence="9"/>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UT21"/>
    <dbReference type="STRING" id="49390.A0A068UT21"/>
    <dbReference type="Gramene" id="CDP10748">
        <property type="protein sequence ID" value="CDP10748"/>
        <property type="gene ID" value="GSCOC_T00031560001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT21"/>
    <dbReference type="OMA" id="WHVGRFS"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT21"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016629">
        <property type="term" value="F:12-oxophytodienoate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000073">
        <property type="entry name" value="12-oxophytodienoate reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP10748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="375" mass="41628" checksum="462FC944C1BDB0D2" modified="2014-10-01" version="1">MVKKVEHGQEKEQSQQPIRLLTPYKLGNFQLFHRFVLAPMTRQRSYGNLPQPHAVLYYSQRTTKGGLLITEATGVSDTSLIGFPFAPGIWTKEQVEAWKPIVDAVHAKGGIIFCQIAHVGRVSGSQPDGQAPISSTDKPLTPEGFDAPKYSPPRRLKTEEIPGIVNDFRLAAINAIEAGFDGVEIHGAHGFLIDQFLKDQINDRTDEYGGSLENRCRFALEIVEAVSDAIGSHRVGLRLSPFANYYEAGDSNPKALGLYIAEALNKPKILYCHMVEPRMKTLGEKSESADSLMPMRKAFNGTFIAAGGYNREDGDRAVAENQADLVAYGRLFLANPDLPKRFELNASLNKYHRDTFYTSDPVVGYTDYPFLETND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTD7</accession>
    <name>A0A068UTD7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00033812001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Encodes a member of the mid-SUN subfamily of SUN-domain proteins that is localized to both the nuclear envelope and the ER. It is involved in early seed development and nuclear morphology. [TAIR].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTD7"/>
    <dbReference type="FunCoup" id="A0A068UTD7">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTD7"/>
    <dbReference type="Gramene" id="CDP11519">
        <property type="protein sequence ID" value="CDP11519"/>
        <property type="gene ID" value="GSCOC_T00033812001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTD7"/>
    <dbReference type="OMA" id="MENKFIA"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTD7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000062">
        <property type="entry name" value="Galactose-binding protein isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="12">
        <location>
            <begin position="174"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="655" mass="74400" checksum="6AFB6D5816AE173D" modified="2014-10-01" version="1">MQRSRRALLQRRALERAICGRNRLCKVSVSVSVSVSAVVVLWGLVFFLNIWFGQSDNYKDGSTDFPVSVRIWDGDKREPDVGQSSASPDGRSSLTETPSVDSTEASCSEAGGTENVNGKLEDLSNDASPDSRFQEQGLGGKSDIATTSVREDSISDRFSLAVPLGLDEFKNRAISSRSRYMSSHAGSIKHRVEPGGAEHNYASSSKGAKVLASNKDAYGASNILSKDKDKYLRNPCSAEEKFVVIELSEETLVDTVEIANFEHHSSNLKEFELLGSQVYPTDTWTKLGNFTAGNTKHAHSFVLPEPKWVRYLKLNLLSHYGSEFYCTLSVFEVYGMDAVERMLEDLISVQDKVIVSDESLSRETHMPHRPVPAEGDSYHNIDSEVEPELAVGHSDTKRVVTTIDVPDPVEEIRQHQVNRMPGDSVLKILMQKVRTLDLNLSVLERYLEELNFRYNKIFREFDREMGEKNVLLENIKSDIRSLQDSKEAMSKEVNDLVAWKSFVSMQLDDIVRSNAVLRWLSFLQSGYFVCTYMVLWLVVFVMQTESERFEWFSRKHWELNHLYAFFTLCQWCCAQLLRLLLEVEKVRRNQVHMENKGIVIFLVCLTFGFFALVRLFVDMALSMYRSQNSGKFWSLGSSWFLLLLSCSITIIILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTL5</accession>
    <name>A0A068UTL5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031967001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTL5"/>
    <dbReference type="FunCoup" id="A0A068UTL5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTL5"/>
    <dbReference type="Gramene" id="CDP10973">
        <property type="protein sequence ID" value="CDP10973"/>
        <property type="gene ID" value="GSCOC_T00031967001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTL5"/>
    <dbReference type="OMA" id="DAGRLMF"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTL5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000055">
        <property type="entry name" value="Amino acid permease 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="12">
        <location>
            <begin position="41"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="468" mass="51399" checksum="956912D8D0AE5733" modified="2014-10-01" version="1">MVESTAPKQGPQNHHQVFGVSVNVPPQGGSKCFDDDGKLKRTGSVWTASAHIITAVIGSGVLSLAWATAQLGWIAGPTVLLLFAFVTYYTSVLLAACYRSGDPDGGKRNYTYMDAVRANLGGFQVKVCGAIQYMNLFGVAIGYTIAASISMTAIKKSNCFHSSGGKDPCKVSSTPYMIIFGVVEILFSQIPDFDQIWWLSFVAAVMSFTYSTIGLGLGIGKVAETGKFRGSLTGISIGTVTQTDKIWRSFQALGAIAFAYSYSLILIEIQDTIKAPPSEYKTMKKATLLSVAVTTIFYMSCGCFGYAAFGDLAPGNLLTGFGFYNPYWLLDIANIAIAIHLVGAYQVYCQPLFAFIEKTARSWFPESQFITKEIEIPIPGFKPYKLNLFRLVWRSIFVVITTVISMLMPFFNDVVGILGAFGFWPLTVYFPVEMYIVQKKIPKWSTRWLCLQILSLACLIISAFKTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUV1</accession>
    <name>A0A068UUV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00035454001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">cv. DH200-94</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WRKY group II-e family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="A0A068UUV1"/>
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        <property type="protein sequence ID" value="CDP12077"/>
        <property type="gene ID" value="GSCOC_T00035454001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUV1"/>
    <dbReference type="OMA" id="WNAFMSE"/>
    <dbReference type="OrthoDB" id="1077642at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WRKY transcription factor 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32096:SF61">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32096">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 30-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WRKY DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="WRKY"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="8">
        <location>
            <begin position="154"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
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            <end position="116"/>
        </location>
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        <location>
            <begin position="236"/>
            <end position="246"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    <reference evidence="2" key="1">
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
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                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="44" mass="4838" checksum="6E328AC595F55E82" modified="2014-10-01" version="1">MGEIHPKPRPVLLSYPLQGHVVPSIHLAKKLASSGFIITFINTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
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    <organism evidence="2 3">
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
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                <person name="Librado P."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
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        <property type="entry name" value="Peptidase_C45_hydrolase"/>
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        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="363" mass="40150" checksum="ECC387BFA71ABA99" modified="2014-10-01" version="1">MEEKPGHEAKQLEIFEVGPVADGYSMGFLIGHRFSGQIRSRLATDLILQNQLLPFAQTPQGRRLINALSENNQKKFPNYWNELLGTAQGSGVPFLDILLLNFRKEILPFIPKSEADLSSRDDNNDDCSDILVVSDYMAIAAHNEDANVALLGHTYLIKGILPNGLCFTAYTYAGELPSCAFAFNSLGLAFTLNSVPPTQSEIVAGGIGRNFISRDLLEAESMDDALTRIRSSEVSVGHSYNLIDTGKRRILNVETASRTRVSVLEVGETPFFHANMYLHLQVQQVQDENSLTRQKSAALLPKSSKIDFLSLLGDTSDKTYPIYMSGPVLYTLCTVLIDLDENTLSITEGNPEQREPSYVFSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWW7</accession>
    <name>A0A068UWW7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HEAT INTOLERANT 4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037615001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWW7"/>
    <dbReference type="FunCoup" id="A0A068UWW7">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP12921">
        <property type="protein sequence ID" value="CDP12921"/>
        <property type="gene ID" value="GSCOC_T00037615001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWW7"/>
    <dbReference type="OMA" id="ICIPAVV"/>
    <dbReference type="OrthoDB" id="20554at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900034">
        <property type="term" value="P:regulation of cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039313">
        <property type="entry name" value="HIT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33704">
        <property type="entry name" value="PROTEIN HEAT INTOLERANT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33704:SF1">
        <property type="entry name" value="PROTEIN HEAT INTOLERANT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="49162" checksum="BD6B2F2F2D496C68" modified="2014-10-01" version="1">MRKGTKRKAPSRKDGAAKSKPEEAENEASKATVEENNKEEVVEKSQSAAAAAEEEESSKVEQTEENNKSEPSTKLAEEENEEKEKEEQSTKPVEEKKKGKEKVEPSKVVKRRGKRARITKQEDEPEYFEEKRNLEDLWKQVFPVGTEWEQLDLVYQYKWSFQNLEDAFEEGGELHGKKVYLFGCTEPQFVSFQGQQKLVVIPVVVAVVSPFPPSDKIGITSVQRESEEILPMKQMKMDWIPYIPFANRDSQVERLKSQIFILACTQRRAGLKHLKIDRVKKFEYCLPYFYQPLREDEFENKTDVDILFPDTEPPIVCEFDWELDELEEFTDKFIEEDQLPADKKDAFKEFVKEKVREAKKANREAREARRKAIEEMSDETKAAFESMKFYKFYPVTTPDSPDVSSVKAPFINRYYGKAHNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX51</accession>
    <name>A0A068UX51_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037734001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX51"/>
    <dbReference type="FunCoup" id="A0A068UX51">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UX51"/>
    <dbReference type="Gramene" id="CDP13006">
        <property type="protein sequence ID" value="CDP13006"/>
        <property type="gene ID" value="GSCOC_T00037734001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX51"/>
    <dbReference type="OMA" id="MDCIILP"/>
    <dbReference type="OrthoDB" id="1052757at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35296">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35296:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14335" checksum="27B72CD9FC7A7C5C" modified="2014-10-01" version="1">MDCIILPVAILRKCYSGSRLGYRQLTDDVFGKSDDPVTVVVGKEKREFLVEPFVLEESPFRVLIDMVKKENMGGVVYMKGAKRVIFVDVDAILFEHMLWLMQNDCSSFFQLNLKEIIDFYAQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY89</accession>
    <name>A0A068UY89_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00036287001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY89"/>
    <dbReference type="FunCoup" id="A0A068UY89">
        <property type="interactions" value="2521"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
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    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
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    </dbReference>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="309"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="10">
        <location>
            <begin position="666"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00007806"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="CDP12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="101834" checksum="FED71489C0E31E9A" modified="2014-10-01" version="1">MTPKLSSLSRRNLHFLQLLLQYQWQLCVLLMVFNLQKSLLAAEEPQEFVDYGYTVKSVGINSAGNSLTAHLELIKNSTVFGPDLPQLLLTASFETNGRLRIRITDPNSRRWEVPYDILPRQPPPPPPHTPPQPPHNRHLLSDRTSDLEFRLSSTTPFGFSVSRLSTGETLFDTTPETNNPNTFLIFKDQYLQLSSSLPSDGANLYGLGEHTKSSFQLKYNQTLTLWNADILSTNIDVNLYGFHPFYMDVRSPNGRSHGVLLLNSNGMDVVYTGDRITYKVIGGIIDLYIFAGPTPNMVVDQYTQLIGRPAAMPYWSFGFHQCRWGYKNVSNLEAVVANYAKAGIPLEVMWTDIDYMDGFKDFTLDPVNFPFDKMKNFVDALHLNSQKYVLIVDPGISINETYGTYIRGKAEDIFIKRDNISYQGVVWPGNVYFPDFVNPAAGLFWSNEINQFHNIVSFDGLWIDMNELSNFITSSPTPSSPLDDPPYKINNHGAKKSITYLTVPATAMHFYDFTEYNVHNLYGFLESRATNQALVKLKGKRPFVLSRSTFVGSGKFTAHWTGDNAATWDDLAYSIPTILSFGLFGIPMVGADICGFSLNTTEELCRRWIQLGAFYPFARDHTTKDSNSQELYLWDSVAASAKKVLGLRYRLLPYFYMLMYEAHTKGTPIARPLFFSFPEDVNTYGISSQYLLGKGVMISPVLKPGAVTVDAYFPAGNWFSLFNHSQSVSLSQGKYVTLDAPLDHINVHVREGNVLAMQGEAMTTEAARKTQFNLLVVLSKNENSTGELFLDDGEEVEMGSEKGRWTLVQFNSHVYKSFVRLETKVVNGNFASSQKWTINKVTFLGLENVRALKGYQISTSNAQRRNQNAGISSSFKLSGQFASVEVSGLNTLIEEEFKLELNLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V186</accession>
    <name>A0A068V186_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00040856001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739169">
        <property type="protein sequence ID" value="CDP14426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V186"/>
    <dbReference type="STRING" id="49390.A0A068V186"/>
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        <property type="protein sequence ID" value="CDP14426"/>
        <property type="gene ID" value="GSCOC_T00040856001"/>
    </dbReference>
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    <dbReference type="OMA" id="TIPIACH"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V186"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF93">
        <property type="entry name" value="ISOFLAVONE REDUCTASE HOMOLOG P3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="106"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="227" mass="25525" checksum="FC5855246D109B66" modified="2014-10-01" version="1">MTIPIACHIKIGDLYDHESLVKAIKQVDVVISTVGQNQLDDQGKIIDAIKEAGNVKRFYPSEFGVDVDRQDAVGPVKFGFGKQQHSVIHFHLLHLIKMFLSSAQLIPYIVQHDVGTFTIKTVDDPRTLNKVVYINPPKNRASFNELVAIWEKKIGITLETEYISEEQLLKNIQEAPSPLDAILSINHAILVNGTSNFPIEPSFGVETSELYPDVKYTTVEEFLHQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V221</accession>
    <name>A0A068V221_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00041084001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V221"/>
    <dbReference type="FunCoup" id="A0A068V221">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V221"/>
    <dbReference type="Gramene" id="CDP14559">
        <property type="protein sequence ID" value="CDP14559"/>
        <property type="gene ID" value="GSCOC_T00041084001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V221"/>
    <dbReference type="OMA" id="CRWFSHE"/>
    <dbReference type="OrthoDB" id="654677at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V221"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000268">
        <property type="entry name" value="probable receptor-like serine/threonine-protein kinase At5g57670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000284">
        <property type="entry name" value="Putative receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046958">
        <property type="entry name" value="RBK1/2/STUNTED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47987">
        <property type="entry name" value="OS08G0249100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47987:SF11">
        <property type="entry name" value="RECEPTOR-LIKE CYTOSOLIC SERINE_THREONINE-PROTEIN KINASE RBK1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="336"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="686" mass="75566" checksum="7FFEB1A8E9CD4DC5" modified="2014-10-01" version="1">MNQGRAEMGIGEEDMGREKRSVVVGIGFDGHTRELLDWAVVKVADPGDCVVALHVCRNSDSTSKAQALMDDYLDEYKDLCHQKQVGLAVEVVKGSSIRKLLVREAKNRAAVAVIVGINKNSLLGGRVSIAKHCAKRLPLTTEVMAIHNGKVVYRRCCNDQQQQPGSQGDPKPSLYLNGNPTCTECPSEFGDSEISDLGRLSHEVCQSSECGCTEADRYPRDESVISPTQRRKRSSLSSISLPVEDFTQQRPGWPLLQTASAITQPSVEARKMTVVQWVMSLPNRSLLEIPQNALGRTDNVSVSAQPPSDLELLLSTKSPGCKLFSHETLKSATSQFCSDNLIGKGGCNCVYKGILPDGKPVAVKILKSSKEAWKEFSLEVDIMTTLKHRSITPLLGICISDNDLISVYDFVPKGNLEENIHGTGKERFVLPWEVRFKIAIGVAEALNYLHSRCARPVIHRDVKSSNILLADEFEPQLSDFGLAIWGPTKASFITDCDVVGTFGYLAPEYFMYGKVSEKVDVYSFGVVLLELLSGRKPIGFDTSKGRESLVIWAKPKLESGDVKGILDQNLDDNFDESEMHRMALAAKLCLTQAARVRPKMSQILKILTGEEHLGEEISTELGANPENQGDYDDDEVYPDSSAESHLSLALLDVCDNSTSFSSQDQSSPLSVEDYLRRRWSRSSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V243</accession>
    <name>A0A068V243_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LOB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039128001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V243"/>
    <dbReference type="STRING" id="49390.A0A068V243"/>
    <dbReference type="Gramene" id="CDP13973">
        <property type="protein sequence ID" value="CDP13973"/>
        <property type="gene ID" value="GSCOC_T00039128001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V243"/>
    <dbReference type="OMA" id="PVNERAD"/>
    <dbReference type="OrthoDB" id="2020166at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V243"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF15">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="167" mass="18620" checksum="87520F1BAC9E098C" modified="2014-10-01" version="1">MGGHSPCASCKLLRRRCTKDCPFAPYFPADDPHKFAIVHKVFGASNISKMLQELPVHQRADAVSSLVYEANARVRDPVYGCVGAISYLQNQVSELQMQLAVAQAEIFCIQMQQDPMAMPTPQFDDDDEGSFLLQHNLPQYLNFASSSSNVIQESFKKESPFGRDMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V318</accession>
    <name>A0A068V318_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042593001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V318"/>
    <dbReference type="FunCoup" id="A0A068V318">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V318"/>
    <dbReference type="Gramene" id="CDP15051">
        <property type="protein sequence ID" value="CDP15051"/>
        <property type="gene ID" value="GSCOC_T00042593001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V318"/>
    <dbReference type="OMA" id="EVYESWG"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V318"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000001">
        <property type="entry name" value="Mitochondrial transcription termination factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF133">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="417" mass="47936" checksum="EC6B4F80FB9E7D5F" modified="2014-10-01" version="1">MLSAYLFYRLSPIKISAKIPTACFILLQKGHLLSSSIFARGSRNDCCANFCSLAEAIDSGYGVKSRTANSALDEYSHSYIVSYLVNSCGLPAERANFLSKRVTFKSLEKPNAVLAFLRDQGFSKAHIAKLVGAAPQILFYNPEKILLPKIEFFSSIWVSRSELTKNLSANHHLLRSSLKNKILPLYHCLKSMYGTDDRLTSPRIWRAVYFSKDPTKNLASNIAVLRELGVRESCIRSLMTRHPAAVMVNDNRFREVVFEVKNMGFDHLKSTFVQALYARFGMRNRLNWERCCEVYRSWGWSEDLVRNAYGKDPNCMLISEQKLSRMMDFLVNKMGLNSQTVARYPVILNFSLDKRIIPRGSVIHLLRLKGFIRWYTRLYSIFIPGEKYFLSKFVIPYEKQVPQLRDVYQGKMGIFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V598</accession>
    <name>A0A068V598_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Toprim domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016712001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739195">
        <property type="protein sequence ID" value="CDP15836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V598"/>
    <dbReference type="STRING" id="49390.A0A068V598"/>
    <dbReference type="Gramene" id="CDP15836">
        <property type="protein sequence ID" value="CDP15836"/>
        <property type="gene ID" value="GSCOC_T00016712001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V598"/>
    <dbReference type="OMA" id="GCKYRTM"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V598"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00188">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF6">
        <property type="entry name" value="TOPRIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="387" mass="43805" checksum="BA4AE56A1095AE48" modified="2014-10-01" version="1">MPLPSRTILHQDSITAIIPSVYSLNPFTSHQFKVQPLIYLASAAKPISRISLYNNGFRSISQRKTGAEFKDKNHEQEESSDYSELKQKLDEVGLNYYNSCSPGQYHLLFCPKCKGGRSSVRSLSFHITLDRTSAIWRCFTAECGWAGQVIPGSWTNISGDNQFGKRQKLQPLGDELIAYFAGRMISKQTLEKNCVMQVAGQKDIIAFTYRRNGIIVGCKYRTMDKSFWQEKGTEKTLYGLDDIKEADEVIIVEGEIDKLSLEEAGISNCVSVPAGAPQTVSIKELPTLEKDTGFQYIWNCKKYLNKASRIIIATDADVSGDALAEELARRLGRERCWRVHWPKKDEINCFKDANEVLMNLGPNALRETIYSMQLHHMYLFNETIQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5S9</accession>
    <name>A0A068V5S9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016841001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5S9"/>
    <dbReference type="STRING" id="49390.A0A068V5S9"/>
    <dbReference type="Gramene" id="CDP15922">
        <property type="protein sequence ID" value="CDP15922"/>
        <property type="gene ID" value="GSCOC_T00016841001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5S9"/>
    <dbReference type="OMA" id="THHIFNL"/>
    <dbReference type="OrthoDB" id="1691246at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5S9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363:SF17">
        <property type="entry name" value="HEPARANASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363">
        <property type="entry name" value="HEPARANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="164" mass="18859" checksum="10408A0887BE4D4E" modified="2014-10-01" version="1">MNHYLHSQAEIIFGLNALNRRRIRSGGSTVGAWDSSNAEAFIRYIVEKGYNIYGWELGNELCGGRVGTRVAPDQYASNTIALRNKVQEIYKDVANKPIVLVPGGFFDVNWFTDFLCRTNNAVDLYWNRLPFFFYLNQVVKIICLTYLCAYNLLKKMNFCLFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V603</accession>
    <name>A0A068V603_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00042980001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V603"/>
    <dbReference type="STRING" id="49390.A0A068V603"/>
    <dbReference type="Gramene" id="CDP15303">
        <property type="protein sequence ID" value="CDP15303"/>
        <property type="gene ID" value="GSCOC_T00042980001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V603"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP15303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="493" mass="55934" checksum="645CA5A1F4B967DD" modified="2014-10-01" version="1">MDPQTEHLHFLLIPLMAQSHIIPLTDFAKLLARQGPMVSMISTPKNANRFKALIDYAERENLKIQFITIPFPGQQVGLPEGCENLDALPSTDLKRSFVDACSLMQEPIENVAKKQLQPRPSCIISTNALVWTQNLAHRLGIPRYVFQTVSSFTLVCAGRIGRFLESHDSSDLDAFWVPNLPHKIQFRKSQLPFPVSRKESGDVRKETQVSDRGSLVNSFEELDQWYVEEQKRVHKNFWDVGPVSLINSTGSATAKSDHYSLKWLDSMKPSSVIYACFGSMCHLSFRQLREIGLGLEASGRPFIWVIREIDYSPQVEKWLKDEKFEERVKGVVVRGWAPQVPILSHSSVGGFLTHCGWNSTLEGICAAVPMLCWPMFAEQFYNEKFVVDVVKIGVRIGVETHMRVGEEEKTVDREQIKAAIDQLMDEGEEGQERRETARKLSEMARNATQQGGSSYRNVILLIQDVLQLQQQEAAEDEKVNEDRGSEIADKRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6I0</accession>
    <name>A0A068V6I0_COFCA</name>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015364001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP15508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="GSCOC_T00015364001"/>
    </dbReference>
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    <dbReference type="OMA" id="ANWVLEN"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="123"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="482" mass="52930" checksum="8696E6B8027F2CAC" modified="2014-10-01" version="1">MAILTEEPDPPKPSTETTPKPLSKSKAKTTTSSPPSSSSSTNYTNPFQFWFYFTLTVSLVTLFFISLPSFSTQDPKTWFFNLPPNLRQHYSKGRIFKVQLTPNHPQVEAFSIQDGPFSSDHRVLIVHGFGCSSFAFQGIVKSLGLKGVHAIAIDLPGSGFSDKSVVVAEENVGGSGGVLGGFWEVYGQIKERGLFWGFDQLIEKGYVDYEEDDIRVSKREVVKAIELGDEEMGRVLSQVIDAMGLAPVDLVLHDSALGLSANWILENARLVRSVTLLDSVPSRTALPSWALELPVVREAVLGVGLVFQSVLGKYCLKSVGKAEAEAHRLLLKGRNGRRSAVGMVKRANHSLDLSEWSGLNEVKDLPMRVIWSSGSSKEWSEEGSRVADALSQATLVSHSGGAWPQEHVSEEIAESIYEFISALPKSTRQSEEEPIPEHVQMMLDDAKGNDHHNHHHHHHHGHDGHAHAGYSDAYGLGHGWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V763</accession>
    <name>A0A068V763_COFCA</name>
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        <recommendedName>
            <fullName evidence="4">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00015700001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068V763"/>
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        <property type="gene ID" value="GSCOC_T00015700001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V763"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658636" description="MIR domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP15703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="129" mass="14388" checksum="3A9C700CD2235AFA" modified="2014-10-01" version="1">MAISFFGLAIFLFLTLDSDFTSSPISTASEGVQITYGSVIKLMHERTTFRLHSHDVPYGSGSGQQSVTGFPNVDDSNSYWIVRPVPDTNAQQGDTIKGGTIIRLQHMRTRKWLHSHLLNVSLTMMPIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8L5</accession>
    <name>A0A068V8L5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00019363001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739221">
        <property type="protein sequence ID" value="CDP16829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8L5"/>
    <dbReference type="FunCoup" id="A0A068V8L5">
        <property type="interactions" value="2500"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8L5"/>
    <dbReference type="Gramene" id="CDP16829">
        <property type="protein sequence ID" value="CDP16829"/>
        <property type="gene ID" value="GSCOC_T00019363001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8L5"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8L5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP16829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="21226" checksum="0E5A2E99F50DC7D9" modified="2014-10-01" version="1">MGLLSIIRKIKRKEKEMRILMVGLDNSGKTTIVMKINGEDTSVISPTLGFNIKTIIYEKYTLNIWDVGGQKTIRSYWRNYFEQTDGLVWVVDSSDLRRLDDCKYELHNLLKEERLSGASLLIFANKQDIQGSLSPDEIAKVLNLEAMDKSRHWRIVGCSAYTGEGLLDGFDWLVQDIASRIYMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8R2</accession>
    <name>A0A068V8R2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-acyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00004940001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8R2"/>
    <dbReference type="FunCoup" id="A0A068V8R2">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8R2"/>
    <dbReference type="Gramene" id="CDP17036">
        <property type="protein sequence ID" value="CDP17036"/>
        <property type="gene ID" value="GSCOC_T00004940001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8R2"/>
    <dbReference type="OMA" id="HVSINPW"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8R2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF306">
        <property type="entry name" value="PROTEIN S-ACYLTRANSFERASE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="160"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="514" mass="58293" checksum="CF2F37D82EA384AE" modified="2014-10-01" version="1">MRRHGWQRPLHPLQIVGMSVFILLVAAFYCFLGLFLGSAIAEITVTTVFSFAALSASFLFIRCTAIDPTDKTRYRFRRRKKTTVKARTISSNLKFGFFALGHLLARVFRRVERKILRTFIRRKYLLLDHQQPSVPLLPFHLLVLRDDDSASVAPHPKELDLSFCALCDFEVQKHSKHCRTCNRCVEGFDHHCRWLNNCVGKKNYTTFILLMVFVLIMLIVEGGTAIAIFIRCFADQEGIEIELNRRHYLKFPRGVLAVISVLLVMMTAYSSIALGQLFFFHMLLIRKGMRTYDYILAMKEENQFMEVESGEDSDFSSDESTDSSSPEKPSFMSRVTCSEGGINQNPEKLTITIDRQAGASTTNEKQGFRASINPWKLITMSQEKAILAANRAKERLMKQKTMTQHDPLEPLPLETKSGPSIKPEKSIGSNMGTGLTPLILKETIPGSPGKFSSPRRRISCSPTIPSAIMGSPKQRYRSNFDLQLTQVSSELETYISRQVLSSILRKDGNRISPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9I5</accession>
    <name>A0A068V9I5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00003777001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739237">
        <property type="protein sequence ID" value="CDP17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9I5"/>
    <dbReference type="STRING" id="49390.A0A068V9I5"/>
    <dbReference type="Gramene" id="CDP17301">
        <property type="protein sequence ID" value="CDP17301"/>
        <property type="gene ID" value="GSCOC_T00003777001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9I5"/>
    <dbReference type="OMA" id="RSYKEEW"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9I5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="58"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="322" mass="36050" checksum="AADDC17FA80810C7" modified="2014-10-01" version="1">MASSHPIHQANENSPYGDLTREEFYKKHQILHKESFMLNKKSMKIFTQSWQPDSTARLKGLVGMIHGYSSESSWLFELNAVAIAKAGYFVCALDLEGHGYSEGLPGQISNFQFLVSDCILFFNSARAEHPKLPAFLYGESMGGAIAILIGLRQRNEWNGIVLSGPMCGVSNKFKPLWPLEKLLPVAAFIAPSWRITFMKPPARGSYKEAWKKQLVAKSPNRPSSGKPPAITAQELMKTCSYIQRKCHELEVPLLILHGEDDRICDPEAAKFVFESAASKDKTLKIFAGMRHQLIGEPNESVELIFGTVISWIEVRAELDHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAP1</accession>
    <name>A0A068VAP1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00003914001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAP1"/>
    <dbReference type="FunCoup" id="A0A068VAP1">
        <property type="interactions" value="1688"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAP1"/>
    <dbReference type="Gramene" id="CDP17791">
        <property type="protein sequence ID" value="CDP17791"/>
        <property type="gene ID" value="GSCOC_T00003914001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAP1"/>
    <dbReference type="OMA" id="GPHIFMC"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAP1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041540">
        <property type="entry name" value="VATC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18716">
        <property type="entry name" value="VATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VLRF1" evidence="16">
        <location>
            <begin position="247"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="537"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP17791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="697" mass="78000" checksum="906C362A7E9A08A3" modified="2014-10-01" version="1">MATEAPSSTSSTGKANHPYQQKNQHRQDEKSHRSIFELPADFFDSCRFLQSPSSSIIVPADDDAAHDGFSRNQEDERLESNISENTNAIGGRGSMERWSCNTCKAEFESLQDQRSHFKSDIHRLNIKLSIAGKGTVKEEDFNETTSDSLCKDYDVSSISGSSEEDEQETGRNMGLHGRLVGVLKHKLFLQLQNGERVSFWKCLLLNESENIVFEIDKSIAADFGECFLTEKDVTEKLKYVIHEPRDATRLRVVLLARGGHFAGCVFDGNSIVAHKTFHRYVVRAKSGKRQSSKDASGKTVHSAGASLRRYNELALKKEIQELLAAWKPYFSVSSCVFLYAPSSNYQLFFDGERPNFNCQHHVIRNIPLTVRRPTLKEARRIYNLLTQVSSENDEQIKSSTPTNTRKEAYLPDSLASDGQFESMKMDTGENLDNQAITDICGVINKLENVHVSSSPESESEIVCASTPLHEAAKTGNSQEVLELLEQGLDPCIKDELGRTPYMLAIEKEVRNTFRRFMALNLDKWDWHAAKVPSALTKEMEESQAIKQVEKDAKRKARAKELKKLRKAREKKAQAEAAQSQNASPMLQNHGSVPISSLKGQFESSSLSKEERLKRAQDAEREKRAAAAERRIAAAAALRPQGTGSLASSSQMKVTETSDTVCSCCHVSLAGIVPFHRYNYKYCSASCMHVHKEILDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB45</accession>
    <name>A0A068VB45_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Subtilisin-like protease fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00007209001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739277">
        <property type="protein sequence ID" value="CDP17956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB45"/>
    <dbReference type="FunCoup" id="A0A068VB45">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB45"/>
    <dbReference type="Gramene" id="CDP17956">
        <property type="protein sequence ID" value="CDP17956"/>
        <property type="gene ID" value="GSCOC_T00007209001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB45"/>
    <dbReference type="OMA" id="GVFSSHQ"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB45"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000003">
        <property type="entry name" value="Subtilisin-like protease SBT1.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="12">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="100"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="13">
        <location>
            <begin position="610"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP17956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="77755" checksum="D4BEE2E12D5E5B77" modified="2014-10-01" version="1">MPKAFSSHQSWYLTTLESISDATSEATIDFPPSSKLLYTYTNALHGFSAILSPSELRAMKDSPGFVSAIKDKSVKMDTTHSSKFLGLNSKYGAWPNSDYGKDVIIGLVDSGVWPESKSYSDDGMTEIPSRWKGQCESGTQFNSSSCNKKLIGARFFNKGLLAKFPNLTISMNSTRDTDGHGTHTSSTAAGSYVEGASFFGYASGTAIGMAPRARVAMYKALWEEGTYTSDVVAAIDQALIDGVDVLSISLGIDGVPFYQDPVAIGTFAALEKGIFVSTSAGNEGPIFGTLHNGTPWVLTVAAGTMDREFTGTVFLGNGISISGLSLYPGNSTAAKVPIVFMNKCENQTELKELQGKVVVCQDKDQTLNNQVNNVQNSKVAGAVFITNNTDLEFFLESQFPAVFLNLEDGEEVLDYIKSSSAPKAKLEFHGTQLGTKPAPRVASYSSRGPSQSCPFVMKPDIMAPGALVLAAWPPNSPVTLVDSGQLFNNFNIISGTSMACPHAAGVAALLRGVHPDWSPAAIRSAMMTTADILDNTNHPITDIGSDNEAANPLAMGTGHLNPNKALDPGLIYDAGIEDYVNLLCALNYNSSQIQTVTRSSSHNCSKPSLDLNYPSFIAYFAASGNRSTTQEFSRTVTNIGSEMSVYVAKLVPLDGFKVSVTPDTLSFRQKYEKKSYKLTIEGFSVLKNSLVFGYLSWEDTGGNHVVRSPIVATTLTVKTLSGHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCT3</accession>
    <name>A0A068VCT3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00013595001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAA-amido conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739314">
        <property type="protein sequence ID" value="CDP18359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCT3"/>
    <dbReference type="Gramene" id="CDP18359">
        <property type="protein sequence ID" value="CDP18359"/>
        <property type="gene ID" value="GSCOC_T00013595001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCT3"/>
    <dbReference type="OMA" id="NAPQFAF"/>
    <dbReference type="PhylomeDB" id="A0A068VCT3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF33">
        <property type="entry name" value="INDOLE-3-ACETIC ACID-AMIDO SYNTHETASE GH3.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH3 middle" evidence="3">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="4">
        <location>
            <begin position="209"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP18359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="356" mass="40498" checksum="24DA14D2FEBC8D7F" modified="2014-10-01" version="1">MSSNIRTGQMSDWITDPNCKRAVSLILSKQMPDLADSIDLVCQEKSWEGIIKKIWPRTKYVMAIITGSMAQYIPALEFYMGGLPVVSPLYGSSEALFGINMKPLCSPYDVSYTFIPNMAYYEFLPIDNHQDPNCTNRKDAHLKDHIVDLANVKVGQHYELLVTTFTGLYRYRMGDIVLVTGFHNSTPQFKFGQRTNVVLSIHTDKTTEQDLQKAIATAIQILEPLGFFLLDYSSYADTSSIPGHYVLFWELQLRSNDDIPELDQVKMEKCCSLVEQSLDQEYKMLKNQSISTIGPLEIRVVKQGTFNVLMDFYLSQGTSLNQYKTPKNIKSEKAIEILDSRVVGKFYSREVPNQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDJ5</accession>
    <name>A0A068VDJ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00010516001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739262">
        <property type="protein sequence ID" value="CDP17738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDJ5"/>
    <dbReference type="STRING" id="49390.A0A068VDJ5"/>
    <dbReference type="Gramene" id="CDP17738">
        <property type="protein sequence ID" value="CDP17738"/>
        <property type="gene ID" value="GSCOC_T00010516001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDJ5"/>
    <dbReference type="OMA" id="NEHITIF"/>
    <dbReference type="OrthoDB" id="1729718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDJ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="484"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP17738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="90042" checksum="7CD53960D93D1090" modified="2014-10-01" version="1">MASDNSISRIFPSNAIGALASSSTWSRIPMSSLKVAVETFDGTGHFGMWQGEVMDSLFQQGLDIAIEEKKSDDIEEKEWSTINRLACGTIRSCLSKEQKYAFKNETSAWKLWKALEGKFLKKSGQNKLLMKKILFRFDYQPGTTMNEHITIFNQLVADLLNLDVNFEDEDLALMLLSSLPDEFEHLETTLLHGKENVSLDAVCSALYSRELRKQDKKKKKVAAADEALVARGRQQSQSKGRRGWSKSISRVAKDECAFCREKGHWKKDCPKLKKKGKAPQDVNVAECKSDAESDFSLAVSRLTSHPDEWILDSTCTYHMTPMREWFFEFEELDGGFVYMGNDNPCKTVGIGSIKLRNHDGSTRILKDVRYVPNLKRSLISLGLLESKGLEVRMRDGILKVTSGALLMLKGVRKNNLYYYQGSTVVGTAAVATSSSSKKDAEATKLWHMRLGDAGEKSLQNLAKQGLLKGTKVCKLEFCEHCVLEKQRKVKFGTGIHNTKGILDYVHSDVWGPAKTPSLGGRYYFVTFIDDFSRRVWVFTMKSKDEMLKIFLKWKARVENQTGRKIKILRTDNGGEYKSDPFQKICQECGIVRHFIVRKIPQQNGVSEHMNKTLVEKVRCMLSNAGLGRKFWAEAVTYAQHLVNRLPSSAIGGKTPLEVWSGKLATDYDSLRIFDSTAYYHVNESKLDPRAKKALFMGFSAGVKGYRLWYLEAKKTIISRDVTFDESVMLNKITQDGTSGTPQQVECTPKQVEFEQIVVSPANSTISDSPMAEEESDEEEVSTQEPQQQQKSIAVNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDK6</accession>
    <name>A0A068VDK6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184A-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00003861001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDK6"/>
    <dbReference type="FunCoup" id="A0A068VDK6">
        <property type="interactions" value="2915"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDK6"/>
    <dbReference type="Gramene" id="CDP17753">
        <property type="protein sequence ID" value="CDP17753"/>
        <property type="gene ID" value="GSCOC_T00003861001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDK6"/>
    <dbReference type="OMA" id="IIKPIMA"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46866" checksum="529A1827E56284F9" modified="2014-10-01" version="1">MGPLYYIIVALPCTIGAIALAISHIYRHLLNYTEPTYQRYIVRIIFMVPVYALMSFLSLLLDDKAIYFDSIREIYEAWVIYNFLSLCLAWVGGPGAVVISLSGRVLKPNWCLMTCCFPPIPLDGRFIRRCKQGCLQFVILKPFLVAITLILYAKGKYEDGNFNPMQAYLYLTIIYTFSYSMALYALALFYVACRDLLQPFNPVPKFIIIKSVVFLTYWQGVLVFLAAKSGFIKDTKEAAEFQSFIICVEMLIAAVGHLYAFPYKEYAGANVVGSRGFTASLAHALKLNDFYHDTVHQFAPTYHDYVLYNHSEGEEGARKYRARTFVPTGPEMDTVRKSKHIFGNKLEDIQLSSLSSSGSSTPQNPGAVQDTAKSEAMNSSLLMDSSNGLSAPYDLSLIDIDMSNYPAKVPAANESGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDQ3</accession>
    <name>A0A068VDQ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Light-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00001014001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP18975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068VDQ3">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDQ3"/>
    <dbReference type="Gramene" id="CDP18975">
        <property type="protein sequence ID" value="CDP18975"/>
        <property type="gene ID" value="GSCOC_T00001014001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDQ3"/>
    <dbReference type="OMA" id="EFCERPY"/>
    <dbReference type="OrthoDB" id="2011897at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDQ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009856">
        <property type="entry name" value="Lir1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36762">
        <property type="entry name" value="LIGHT-REGULATED PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36762:SF2">
        <property type="entry name" value="LIGHT-REGULATED PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07207">
        <property type="entry name" value="Lir1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14482" checksum="94D19D9D8FB7265B" modified="2014-10-01" version="1">MQAALSLAPPILPLQTPARCFRSQSKSIPAIQTSSLFARMKAAAVANDTSTVDYSSTTSVFPAEACETLGGDACDVEMYPEAKLNPGLTDKRPQTASEQVEREYLEYNSPKTVFEGDACDELGGEFCQPEHQSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEJ0</accession>
    <name>A0A068VEJ0_COFCA</name>
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        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00009283001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739409">
        <property type="protein sequence ID" value="CDP19012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEJ0"/>
    <dbReference type="STRING" id="49390.A0A068VEJ0"/>
    <dbReference type="Gramene" id="CDP19012">
        <property type="protein sequence ID" value="CDP19012"/>
        <property type="gene ID" value="GSCOC_T00009283001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEJ0"/>
    <dbReference type="OMA" id="EMINIMP"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEJ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF540">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="67" mass="7863" checksum="A7BC62215C7A0893" modified="2014-10-01" version="1">MEQKFSLTPKLEHYGCMVDLLGRAGDLQEAYHLIWSMPMKPDFVIWGTMLGPCSLFFFFFFFWGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEQ7</accession>
    <name>A0A068VEQ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine aminopeptidase 2</fullName>
            <shortName evidence="12">MAP 2</shortName>
            <shortName evidence="12">MetAP 2</shortName>
            <ecNumber evidence="12">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00002104001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="function">
        <text evidence="11">Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="12"/>
    <dbReference type="EMBL" id="HG739428">
        <property type="protein sequence ID" value="CDP19082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEQ7"/>
    <dbReference type="FunCoup" id="A0A068VEQ7">
        <property type="interactions" value="3437"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEQ7"/>
    <dbReference type="Gramene" id="CDP19082">
        <property type="protein sequence ID" value="CDP19082"/>
        <property type="gene ID" value="GSCOC_T00002104001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEQ7"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000106">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000003">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="15">
        <location>
            <begin position="117"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP19082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="426" mass="47828" checksum="324D1AB6589BEE63" modified="2014-10-01" version="1">MAKDDELGAGAVPEEEGPSETAAADETEEKVEDKVDELTLDGPQEAAKKKKKKSKSKKKKELRVQTDPPSIPVIELFPSGEFPEGEVQQYKNDNLWRTTSEEKRELERLEKPIYNSVRQAAEVHRQVRRYIRQILKPGMLMIDLCETLENTVRKLISENGLQAGIAFPTGCSLNWVAAHWTPNSGDKTVLQYDDVMKLDFGTHIDGHIVDCAFTVAFNPMFNPLLEASREATNTGIKEAGIDVRLCDVGAAIQEVMESYEVEINGKVYQVKSIRNLNGHSIGSYQIHAGKSVPIVKGGEQTKMEEGEFYAIETFGSTGKGYVREDLECSHYMKNFDVGHIPLRLPRAKQLLATINKNFSTLAFCRRYLDRLGETKYLMALKNLCDSGIVQPYPPLCDIKGSYVSQFEHTILLRPTCKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFK7</accession>
    <name>A0A068VFK7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00002594001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell wall biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyltransferase 37 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG739542">
        <property type="protein sequence ID" value="CDP19372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFK7"/>
    <dbReference type="FunCoup" id="A0A068VFK7">
        <property type="interactions" value="1314"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFK7"/>
    <dbReference type="Gramene" id="CDP19372">
        <property type="protein sequence ID" value="CDP19372"/>
        <property type="gene ID" value="GSCOC_T00002594001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFK7"/>
    <dbReference type="OMA" id="VSHCEDM"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFK7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009969">
        <property type="term" value="P:xyloglucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11340:FF:000005">
        <property type="entry name" value="Galactoside 2-alpha-L-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004938">
        <property type="entry name" value="XG_FTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31889">
        <property type="entry name" value="FUCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31889:SF2">
        <property type="entry name" value="FUCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03254">
        <property type="entry name" value="XG_FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="571" mass="65365" checksum="EAE92BD2D1EC3648" modified="2014-10-01" version="1">MIRRFKGNSTTDQTNPVESQNDIVFWDGLEAKCMCSPIKMLRIFVFCLVGFCVFFTVSSVLKDSSSDGIWTLAYARLPDVKPLQKGDIIEQTTFRQPVEVPQDKLLGGLLPAALDEKSCLSRYQSVLYRKKNIHQPSSHLISRLRNYESQHKRCGPYTESYNRTLKYLNSNQYNSSTGCNYVVWLSFSGLGNRILSLASAFLYALLTNRVLLVDRGLDIPDLFCEPFPDVSWLLPSDFPLTDKFSSFNQKSPESYGNMLKNNVFANSVSSSLPAYVYLHLVHDYDEHDKLFFCDQDQTVLQQVPWLILKTDNYFIPSLFLIPSFEQELHNLFPEKGTVLHHLCWYLLNPTNSVWGLITRYYNAYLATADEKIGIQIRVFEGGPGPYQYVSDQILACVIKENLLPQINKNLPIINPPGKPKIKAVLITSLSSGYFEALRNMYWEHPTITGEIIELFQPSHEVYQQTEKQMHNRKAWAEMYLLSLMDKLVTSSWSTFGYVAQSLGGLRPWILYKVENQTAPDPPCQRAMSMEPCFHAPPFYDCKRKIGTDTGKIVPNVQHCEDMSWGLKLFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFV3</accession>
    <name>A0A068VFV3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00012403001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739340">
        <property type="protein sequence ID" value="CDP18573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFV3"/>
    <dbReference type="FunCoup" id="A0A068VFV3">
        <property type="interactions" value="3291"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFV3"/>
    <dbReference type="Gramene" id="CDP18573">
        <property type="protein sequence ID" value="CDP18573"/>
        <property type="gene ID" value="GSCOC_T00012403001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFV3"/>
    <dbReference type="OMA" id="YENGQHC"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFV3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="535"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="659" mass="74209" checksum="EDC34529A94F01E0" modified="2014-10-01" version="1">MNKKKKIGGLRRLFEISIVIIIGCICAITRSAAAAAAKDDQFLLLLGVSPQDEDYYKGLLSSPSSTIKCKDGSFKFSTSQLNDDFCDCPDASDEPGTSACPNGKFYCKNAGHIPFSLYSSRVNDGICDCCDGSDEYDGKVKCPNTCWEAGKVARERLKMKIATYQQGVTVRNRLVEQAKLAIAKEEAELSKLKNEEKILKGLVEQLQERKEQIEKAEEKERLQKEKEDKERKETEEANLKEKQNGEQVESSEADALKNDIHDKIGEQVESSEADALKNDMHDKIGLLGDSSSSQDVMEGHGDSESEAQHGEFDVKEESSIGDVKPLQEDSLLHATEKEEQLTVDGQPGLDTGNQAEVEEDNSESLSKEELGRLVASRWTGEKTEPQTQEVSSAKDKNHGTEEEDAYGEEYSGYDSEEDEHRYDNNDDGDNEDQMDDFGGEDHDDSSPSYKSESDDEPDLPAEPSWLEKIQKSVRRIFQAVTFFQTPVDKSEAARVRKEYDESSAKLSKLQSRISSLTHKLKHDFGREKEFYSFYGQCFENKQNKYVYKICPFKQASQVEGHSTTRLGSWEKFEDSYKVMQFLNGDKCWNGPDRSMKASILLVKLRCGLNNEVTDVDEPSRCEYLALLSTPAVCVEEKLKELQDKLDMMNKEQPTSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG35</accession>
    <name>A0A068VG35_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00006618001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739754">
        <property type="protein sequence ID" value="CDP19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG35"/>
    <dbReference type="STRING" id="49390.A0A068VG35"/>
    <dbReference type="Gramene" id="CDP19770">
        <property type="protein sequence ID" value="CDP19770"/>
        <property type="gene ID" value="GSCOC_T00006618001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG35"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VG35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="149" mass="17518" checksum="60B95EBCC9AB266E" modified="2014-10-01" version="1">MIRYASNSLSRIHFYECSGPWKEQGLCRVDWGRGIDLRLFPEDAKLVDTYGLCVIVHMILHKSCMEIEKRPSPDGGYVYQPKTHLKRYMQVELWKNLFMKLLNTSPTEDHQSLLRNLRHSFQDYMCSNPQLIKKLKQLLVKQKNSLCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGU4</accession>
    <name>A0A068VGU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">DH200=94 genomic scaffold, scaffold_856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00001459001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the two pore domain potassium channel (TC 1.A.1.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739940">
        <property type="protein sequence ID" value="CDP20050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGU4"/>
    <dbReference type="FunCoup" id="A0A068VGU4">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGU4"/>
    <dbReference type="Gramene" id="CDP20050">
        <property type="protein sequence ID" value="CDP20050"/>
        <property type="gene ID" value="GSCOC_T00001459001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGU4"/>
    <dbReference type="OMA" id="WLIDPNY"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000102">
        <property type="entry name" value="Two-pore potassium channel 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF282">
        <property type="entry name" value="TWO-PORE POTASSIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="290"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP20050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="443" mass="48876" checksum="BFD2DCF0377B4BA1" modified="2014-10-01" version="1">MEKEPLLPYVNTRRQPYSPQPPPPPISLCPLPENDEITIPPPNGCLTPSELKDRLIFGTPPSSSSTPLMDSSSSTLVDALALSINSPRKTSSEDLKSNIVGEKCNLDQQNGQQSWLTDPNIPWTKGNLHRSKTAPAMAVINDFDHSSAPKPPVFGSQSIIRQAVVLLIIYLSLGVVIYAFNTDHFKATETHPVVDALYFCIVTMCTIGYGDITPDTASTKLFSIMFVLVGFGFVDILLTGMVSYVLDLQENYLLRTLKNGGAHDPGRFVIDVKKGRMRIRMKVALALGVVILCIGIGVAVIHYVERLGWLDSFYLSVMSVTTVGYGDRAFTSLPGRIFASIWLLVSTLAVARAFLYLAEARVDKRHRSMAKWVLGQDMTVAQFLAADIDNNGFVTKSEFVIYKLKAMGKISEMDILQVCKQFERLDTGNCGKITLADLMENHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGZ9</accession>
    <name>A0A068VGZ9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_133</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_1942</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DH200=94 genomic scaffold, scaffold_202</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_2650</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_817</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00003117001</name>
        <name evidence="5" type="ORF">GSCOC_T00005613001</name>
        <name evidence="9" type="ORF">GSCOC_T00005976001</name>
        <name evidence="8" type="ORF">GSCOC_T00007524001</name>
        <name evidence="7" type="ORF">GSCOC_T00011143001</name>
        <name evidence="4" type="ORF">GSCOC_T00019013001</name>
        <name evidence="1" type="ORF">GSCOC_T00019633001</name>
        <name evidence="2" type="ORF">GSCOC_T00033945001</name>
        <name evidence="3" type="ORF">GSCOC_T00035973001</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739140">
        <property type="protein sequence ID" value="CDP11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739149">
        <property type="protein sequence ID" value="CDP12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739217">
        <property type="protein sequence ID" value="CDP16591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739276">
        <property type="protein sequence ID" value="CDP17954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739286">
        <property type="protein sequence ID" value="CDP18064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739901">
        <property type="protein sequence ID" value="CDP19991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG741026">
        <property type="protein sequence ID" value="CDP20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG741734">
        <property type="protein sequence ID" value="CDP21168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGZ9"/>
    <dbReference type="Gramene" id="CDP04862">
        <property type="protein sequence ID" value="CDP04862"/>
        <property type="gene ID" value="GSCOC_T00019633001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP11595">
        <property type="protein sequence ID" value="CDP11595"/>
        <property type="gene ID" value="GSCOC_T00033945001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP12431">
        <property type="protein sequence ID" value="CDP12431"/>
        <property type="gene ID" value="GSCOC_T00035973001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16591">
        <property type="protein sequence ID" value="CDP16591"/>
        <property type="gene ID" value="GSCOC_T00019013001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP17954">
        <property type="protein sequence ID" value="CDP17954"/>
        <property type="gene ID" value="GSCOC_T00005613001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18064">
        <property type="protein sequence ID" value="CDP18064"/>
        <property type="gene ID" value="GSCOC_T00003117001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP19991">
        <property type="protein sequence ID" value="CDP19991"/>
        <property type="gene ID" value="GSCOC_T00011143001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP20887">
        <property type="protein sequence ID" value="CDP20887"/>
        <property type="gene ID" value="GSCOC_T00007524001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP21168">
        <property type="protein sequence ID" value="CDP21168"/>
        <property type="gene ID" value="GSCOC_T00005976001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGZ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP17954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP18064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP19991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP21168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="71" mass="8204" checksum="DD95DEA851C82DA7" modified="2014-10-01" version="1">MEGLKPLVSFKLENSRFNKQYLKNHISLSTSPKLENLVLLESSFKVLKVLRRHFSTNVSERHSNFGSKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHI2</accession>
    <name>A0A068VHI2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_1063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00013631001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740147">
        <property type="protein sequence ID" value="CDP20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHI2"/>
    <dbReference type="Gramene" id="CDP20265">
        <property type="protein sequence ID" value="CDP20265"/>
        <property type="gene ID" value="GSCOC_T00013631001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHI2"/>
    <dbReference type="OMA" id="EWEDITR"/>
    <dbReference type="OrthoDB" id="1272397at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHI2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF45">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="201"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="564"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="932" mass="106615" checksum="93EAD2E26E69BE4E" modified="2014-10-01" version="1">MAELFVPKIIDQLSDVLVKQFGEKVNLVMGVEEEVANISSKLATIEKVLHDAERRRLKDRCVGIWLEKLEDITYEMDDVLDDWNFKIHRAKNERTRQNARLQPTLWIKVRSLIPSLCSCLKQVPVRSDIALKIKGINEKLELTLKEADQFKFITSGGIPDSQDFQRIITTSMIDESKVCGRESDKVALLDQVLSKSSSQGRKGVQVISVVGAGGSGKTTLAQLLFNNDKVRNHFELRNWICVSDPFDQKRIAKAILENAGKSSQESELDPLIQRIKETFSGKRFLLVLDDVWTEDDSKWEPFQNSLKDGAPGSVILVTTRSHRVAAVVGTTHTHQMALMSDSDCWLIIQRIAFANKSGDLCKKVERIGQKIAEKCKGLPLAAKTMGSLLRFKDTVQQWQNVLDSEIWQLEEAAVELFPHLYLSYNELSPELKRCFSYCAVFPKDHVIYVEELIRLWIAQGYVRPRRRGESLELVGLEYFNNLAMRSFFQELKKAETFYGLTEYMKCKMHDIVHDFAQFLTKNECHALDGTGRNSSSERPRHLTILEEGTEEEMFSSRVVDFGRLRSFLTFPIIGRVVVPQNLFCHLKCVRTLTLSDCELAEIPAEIGRLIHLRHLDLSHNPFITLPEAICDLYYLETLNINNCGKLSCLPERIEGLVRLRHLFNDNTDDLRQIPQGLGKLTSLCTLFWFIARSNSDDLAILKDLNQLERLAIKIEGEVDFGSAKLGKKINMREMFLLFSDGTHFIETPSCIETMEPPPNLELLVLDSYPGAQLPSWLVTKSHANNLTKLSIASPHNISSLLALWKQSSLEELEFRAVEKLECLGKEFFGVTKALHENMAFPNLRKLHFGFLRNWTNWEDSSEDDEEVVVSIMPRLEELKLIQCINLETLPHRILSKISSLKILDIRSCNKLRDHDWIKISHIPRVDISDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHU7</accession>
    <name>A0A068VHU7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_1180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00010237001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740264">
        <property type="protein sequence ID" value="CDP20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHU7"/>
    <dbReference type="FunCoup" id="A0A068VHU7">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VHU7"/>
    <dbReference type="Gramene" id="CDP20410">
        <property type="protein sequence ID" value="CDP20410"/>
        <property type="gene ID" value="GSCOC_T00010237001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHU7"/>
    <dbReference type="OMA" id="HIPEATT"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000081">
        <property type="entry name" value="Cytochrome P450 CYP81N5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF13">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 81, SUBFAMILY K, POLYPEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="511" mass="58527" checksum="72F4B0FF7F521FD8" modified="2014-10-01" version="1">MENLYCCLITILSCSLLLISKNLLFNHVKNKKLPPSPLALPIIGHLYLIKNSLFQDLTSLSAKYGPIFFLQFGWRSFVVVSSPAAIEECFTKNDITLANRPRTMAGDRLTYNYTGPGVAPYGDLWRVLRGLFVVESLSFNSLQRTSVIREEECQMILRSIYRVSKNESQVRVDLSHWISVFTLNVMMRMLVGRCSIREEDAGEELGMQIIEEFREMFGSSISMNLCDFFPVLRWLGYKGLEKEMISLQKKRDNFGQGFIDEFRCSNTLLDKEKKALIANLLSRKEKESVFLSDDAIKSFAFIMFTAGRETSTLTIEWAMLLLLNNRTALQKLRTEIDINIGHGRLLRESDIPKLPYLHCVVNETMRLYPAAPLLQPHYASEDCKVGMYDIPKGTIVLANAWAVHRDPKLWEEPEKFMPERFEVKKLMDKEEFNSKFLPFGMGRRACPGANLAIRSVSLAIGTIIQCFDWDKVEQDGDLDINFSNRITLQKAKHLEALCVPRQESILLLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJT4</accession>
    <name>A0A068VJT4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00008297001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740933">
        <property type="protein sequence ID" value="CDP20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJT4"/>
    <dbReference type="FunCoup" id="A0A068VJT4">
        <property type="interactions" value="2056"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJT4"/>
    <dbReference type="Gramene" id="CDP20834">
        <property type="protein sequence ID" value="CDP20834"/>
        <property type="gene ID" value="GSCOC_T00008297001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJT4"/>
    <dbReference type="OMA" id="GFECDDV"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJT4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="148" mass="16540" checksum="77A118BC098B066B" modified="2014-10-01" version="1">MNATSQQQGQGQGQQQHPNIEGRHDDDAALSEFLASLMDYTPTIPDELVEHYLAKSGFQCPDVRLVRLVAVATQKFIADVATDALQQCKARQSAVVKDKREKQQKDKRLILTMEDLSRALHEHGVNVKHQEYFADSPSAGLDPVSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJZ1</accession>
    <name>A0A068VJZ1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2006</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00009491001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741090">
        <property type="protein sequence ID" value="CDP20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJZ1"/>
    <dbReference type="STRING" id="49390.A0A068VJZ1"/>
    <dbReference type="Gramene" id="CDP20904">
        <property type="protein sequence ID" value="CDP20904"/>
        <property type="gene ID" value="GSCOC_T00009491001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJZ1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJZ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655972" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="73" mass="8839" checksum="6738FFF9B40616CB" modified="2014-10-01" version="1">MHFTIHIALLFMEVVWTANIHDCINGKIWPVMGAGYHTIHRTTYRHNYCHYTIWMDWMFNTLRDPEEDEAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKM6</accession>
    <name>A0A068VKM6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_2615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00002092001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741699">
        <property type="protein sequence ID" value="CDP21149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKM6"/>
    <dbReference type="Gramene" id="CDP21149">
        <property type="protein sequence ID" value="CDP21149"/>
        <property type="gene ID" value="GSCOC_T00002092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKM6"/>
    <dbReference type="OrthoDB" id="1423290at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="47"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP21149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="16179" checksum="6884939CB2D9AB17" modified="2014-10-01" version="1">MDLGRNGDANKLLQAQAHIWNHIFNFINSISLKCTIQLGIPDIIHKHGLNSLVDVGGGTGTLAKEIADAFLDLNCIVTDLPHVVDGLVANNKSLAFVGGDMFVAIPPADDVIMKASLTLFTNEECVQILGKCKEAIPSKENGGKLNFSVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL20</accession>
    <name>A0A068VL20_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00002320001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="HG742955">
        <property type="protein sequence ID" value="CDP21401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL20"/>
    <dbReference type="FunCoup" id="A0A068VL20">
        <property type="interactions" value="2039"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VL20"/>
    <dbReference type="Gramene" id="CDP21401">
        <property type="protein sequence ID" value="CDP21401"/>
        <property type="gene ID" value="GSCOC_T00002320001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL20"/>
    <dbReference type="OMA" id="FTEWELY"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VL20"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP21401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="37474" checksum="6792084AC8AD84E6" modified="2014-10-01" version="1">MLNKIAFLPLQVCFAELNGLLEILPPVEFCCVYGSTLHPNNLDKNSMIDCIIGVSDPEKWHSENLKMNRNHYASWLVRFGGAGLIAGVADDIGVGVHFNPFVSLNDKMYKYGVVRMDDLINDILGWQRFYLCGRLQKPVCFISNLDLENLNHINLRAATSAALLLLPSKFTEEDLYAKICSLSYMGDLRMLFAEDKNKVKKIVQGQFSLFHRMYNPFLEEYAAKDLLRLSSSGDAQVTISQDCGSSAASKLVSSLPPPIRSQMGIKVGEKKILDELGRVKQEVVIGSKEEAAKCMQKLLRNKVMISSARQAVAGLLTVGVFGGAQYVSKKLQKAWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLS5</accession>
    <name>A0A068VLS5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_4917</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00002191001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG744001">
        <property type="protein sequence ID" value="CDP21567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLS5"/>
    <dbReference type="STRING" id="49390.A0A068VLS5"/>
    <dbReference type="Gramene" id="CDP21567">
        <property type="protein sequence ID" value="CDP21567"/>
        <property type="gene ID" value="GSCOC_T00002191001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLS5"/>
    <dbReference type="OMA" id="RSHQNFA"/>
    <dbReference type="PhylomeDB" id="A0A068VLS5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35478">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35478:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="74" mass="8536" checksum="E5C81EEBCA70A33D" modified="2014-10-01" version="1">MEDKETEFLCKLTANHLFLAQFEPLRATLRSLRVRNPELARSILQTIVPKGGRFDSVLRSHQNFANNFGKCRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMR4</accession>
    <name>A0A068VMR4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_9693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00002418001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG748777">
        <property type="protein sequence ID" value="CDP22060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068VMR4"/>
    <dbReference type="Gramene" id="CDP22060">
        <property type="protein sequence ID" value="CDP22060"/>
        <property type="gene ID" value="GSCOC_T00002418001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMR4"/>
    <dbReference type="OMA" id="AMSHNEI"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010253">
        <property type="term" value="P:UDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000236">
        <property type="entry name" value="Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="4">
        <location>
            <begin position="71"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP22060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="361" mass="40257" checksum="2E8C7A81F1E30B48" modified="2014-10-01" version="1">MEWYVKNPDWWGDVSGALVPHPRMLMMSGMGKSSSDVGSIDTSSVSNNSGPMRMVNPGSKNIHDAQKSSLKFLIYGRTGWIGGLLGRICDKQGIAYNYGNGRLQDRAQLLADIQNVKPTHVLNAAGVTGRPNVDWCESHKPETTITNVVGTLTLADVCREHGLLMMNFATGCIFEYDAGHPIGSGIGFKEEDKPNFTGSFYSKTKAMVEELLKEYDNVCTLRVRMPISSDLNSPRNFIAKIAKYDKVVNIPNSMTVLDELLPISIEMAKRNCKGIWNFTNPGVISHNEILEMYRDNIDPKFKWANFTLEEQAKIIVAPRSNNEMDASKLKKEFPELLSIRESLIKYVFKPNKKNLTAGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN39</accession>
    <name>A0A068VN39_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_9225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00004604001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG748309">
        <property type="protein sequence ID" value="CDP22029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN39"/>
    <dbReference type="STRING" id="49390.A0A068VN39"/>
    <dbReference type="Gramene" id="CDP22029">
        <property type="protein sequence ID" value="CDP22029"/>
        <property type="gene ID" value="GSCOC_T00004604001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN39"/>
    <dbReference type="OMA" id="KMKMMET"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN39"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP22029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="181" mass="20220" checksum="8171E159F4D07C9A" modified="2014-10-01" version="1" fragment="single">MDAIIQAPYDATVRLMLASLERNLLPDAVIRRLTRLLLAGRLRSGYKPTSEQQLSDLLAFAHCNSSSCLAPEVLVPLKGHLSNVHLPYNLLEKCGVNSLREMPTAIQTEVPKSQHYELPTSFFKLVLGEHLKYSCCLFLDKSKTLEDAEKAMLELYCERSQIKDGHTVLDVGCGWGSLALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VPQ8</accession>
    <name>A0A068VPQ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DH200=94 genomic scaffold, scaffold_5724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00010014001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG744808">
        <property type="protein sequence ID" value="CDP21683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VPQ8"/>
    <dbReference type="Gramene" id="CDP21683">
        <property type="protein sequence ID" value="CDP21683"/>
        <property type="gene ID" value="GSCOC_T00010014001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VPQ8"/>
    <dbReference type="OMA" id="LECEQSI"/>
    <dbReference type="PhylomeDB" id="A0A068VPQ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000432">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF37">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="468"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP21683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="669" mass="73578" checksum="BB42DF9B53287ED2" modified="2014-10-01" version="1" fragment="single">MALTLRHKHLFGTVSPQVGNLSFMRFIHLEENQFHGEIPQEFGRLFRLRVLNLSNNALGGKIPANLSYCSELITINLAGNNLEGKIPMDELSNLKKLENFNIYSNNLTGEIPSSIGNFSAITVISVPGNSFHGNLTTNIGLTLPNLKRLYVGGNKFYGNFPTSITNASGLELIAIPSNGFKGQIPTNLGDLTNLRFLNLERNLFGSNIPKVMANLSHQLTELYMGGNQLSGTIPEGFGHLVNLYILTLEANSLFGLIPRDFGKLQNLQLLSLAQNELSGQIVPTLCNATTHSSLMYMKMGENSFSGSLPSEIGKLIHLVDFTVSHNQLAGDIPISLADCSNLANLSMQANFFQGTIPPNLASLKSIQQIDLSSNNLTGPIPRELEKLQFLRYLNLSYNDIEGEVPNTGIFSNASQISLIGNNKLSLLYLLVYQKRERRLVAGFSSMPTRVNKLLRISYHELHRATSGFSPENLIGSGHFGAVYKGTLEKHGNKLVAVKVLDLQKNGAKKTFKAECKTLRNIRHRNLVYIVSYCSSIDSKGDEFKALVYEFMEYGNLDLWLHPAETTNQATSSRSLNLSQKLNIAIDVASALQYLHNHCEAEIVHCDLKPSNILLDNDLVAHVGDFGLARLLPKPVNRSSEQEGSSTIAIKGTIGYAAPANCAQTTVWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I6M4H1</accession>
    <name>I6M4H1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">111O18.22</name>
        <name evidence="3" type="ORF">GSCOC_T00037244001</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome microstructure conservation at the ovate locus between coffee and grapevine.</title>
            <authorList>
                <person name="Crouzillat D."/>
                <person name="Guyot R."/>
                <person name="Tranchant C."/>
                <person name="de Kochko A."/>
                <person name="Rigoreau M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM635075">
        <property type="protein sequence ID" value="AEI98635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP02031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I6M4H1"/>
    <dbReference type="STRING" id="49390.I6M4H1"/>
    <dbReference type="Gramene" id="CDP02031">
        <property type="protein sequence ID" value="CDP02031"/>
        <property type="gene ID" value="GSCOC_T00037244001"/>
    </dbReference>
    <dbReference type="InParanoid" id="I6M4H1"/>
    <dbReference type="OMA" id="SCIPICL"/>
    <dbReference type="OrthoDB" id="671923at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34936">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34936:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEI98635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="102" mass="12051" checksum="7FEF47F8A9FCF83E" modified="2012-10-03" version="1">MITRSKLVEQLRDYQIRSQHKCPALTVFSPKPLLTTWDDVMVAILWASLFSALVISSYVTLYFRHYWVSFVIMCFGIFLPVRLRISRQVLARKKERLLPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPK8</accession>
    <name>A0A068TPK8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00022250001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPK8"/>
    <dbReference type="FunCoup" id="A0A068TPK8">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPK8"/>
    <dbReference type="Gramene" id="CDO98225">
        <property type="protein sequence ID" value="CDO98225"/>
        <property type="gene ID" value="GSCOC_T00022250001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPK8"/>
    <dbReference type="OMA" id="HVKREGM"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPK8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14663">
        <property type="entry name" value="STKc_SnRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF162">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="15">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO98225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="448" mass="50437" checksum="71F83F2D06905767" modified="2014-10-01" version="1">MEVQSVKSLAETYGLISGNRNIIFGKYEMGRLLGQGTFAKVYYGRNLNTSESVAIKVINKDHVREDGMMEQIKREISVMRLVRHPNVVEIKEVMATKRKIFFIMEYVRGGELFEKIAKGKLKEEVARKYFQQLISAVDFCHSRGVSHRDLKPENLLLDDDGNLKISDFGLSALPEHLRNDGMLHTQCGTPAYVAPEVLRKQGYDGAKADIWSCGVILYALLAGCLPFRDENVVKMYRKVFKAQFEIPPWFSSDARRLVTKLLVADPGKRISIPAIMRVPWFLKGFTRPTAFTIQEPGQDNLDQKDDVNTEANLVKTKSSPPFYNAFEFISSMSSGFDLSSLFENKRKSGSLFTSKSSASVIMGKLESLAKKLNYKIVGAKEFALKMQGVSEGRKGKLTVKAEVFEVAPEVAVVEFSKSAGDTLEYKKFCDEDVRPALKDIVWSWQGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRD0</accession>
    <name>A0A068TRD0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Outer envelope pore protein 16-2, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025702001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRD0"/>
    <dbReference type="FunCoup" id="A0A068TRD0">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRD0"/>
    <dbReference type="Gramene" id="CDO98781">
        <property type="protein sequence ID" value="CDO98781"/>
        <property type="gene ID" value="GSCOC_T00025702001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRD0"/>
    <dbReference type="OMA" id="HIVQCAI"/>
    <dbReference type="OrthoDB" id="1913857at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRD0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF1">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 16-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23986" checksum="45DC15761BB66CFC" modified="2014-10-01" version="1">MFASCTTTNYKYIHSYFFFFSQITIVVEASSRPPSRARRKRERKETMSSSSNLETRSIIDELRNFDKSGLFDLGHPLLNRIAESFVKAAGIGAVQAVAREAYLTAVEGAGADTSGIPPEISAAKRHRFPDLRGETNAKTVEALVKGTGKESLQWGLAAGMYSGLTYGLKEARGVHDWKNSALAGAVTGAALALTSDGHSHEQIVQCAITGAAISTAANLLTGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSX4</accession>
    <name>A0A068TSX4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022540001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSX4"/>
    <dbReference type="STRING" id="49390.A0A068TSX4"/>
    <dbReference type="Gramene" id="CDO98448">
        <property type="protein sequence ID" value="CDO98448"/>
        <property type="gene ID" value="GSCOC_T00022540001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSX4"/>
    <dbReference type="OMA" id="DPTIGWA"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="156" mass="17019" checksum="6177D5D1A8885C34" modified="2014-10-01" version="1">MGQQPAHAAPVAAVFSAAGPWSTGLCGCFEDTSNCCVTCCCPCITFGRNVEIIDKGTTSCAQAGIIYYCLAHVGCASCYSCTYRSKLRAYFNLSEDPCNDCLVHCFCLPCAVCQEYRELKNRGLDPSHGWIANVERWNQLAVRTTAPPTFEAGMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTH5</accession>
    <name>A0A068TTH5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022800001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTH5"/>
    <dbReference type="FunCoup" id="A0A068TTH5">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98638">
        <property type="protein sequence ID" value="CDO98638"/>
        <property type="gene ID" value="GSCOC_T00022800001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTH5"/>
    <dbReference type="OMA" id="ECIKKMP"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTH5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001630">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g43790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF450">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56284" checksum="3A7EA6EA998BBE2D" modified="2014-10-01" version="1">MNTPLKNHPILQLLYGCKTLNSLLQIHAQMITTGLILHTYPLSRIILVSSSITTNISYAETIFNQVKNPTIFLYNILISCYTRKGKTHDALSLYSRIFSNNMTSSAKPNNYTYPSLFKACGAQLWFQHGKALHAHVLKFLEPPYDQFVQASLLNFYSSCGKIGIARYLFYQTIQPDLAVWNSILSAYATNCSVNFDAHADSFCDSTGLWLEVLHLFSEMQKCSIQPNEVTLVALISACADLGALSQGMWAHGYVVRKKLGLNIYLGSALINMYSNCGRLKLAYQLFDELPERDTFCYNAMIRGLAVHGHGREALQLFEKMALEGLVPDDVTLLVVMFACSHLGLVDQGCKYFYAMHRDYGIAPKLEHYGCLVDILGRAGRVAEAEETIHAMPMKPTAVLWRSLLGAARVHGNIQVGKVALKCLIQLEPETSGNYVLLSNIYASMNRWDDVKNVRKLMKEFGINKMPGTSVLEIDGEMHEFSSGDKTHPKAKEIFEARRYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTI2</accession>
    <name>A0A068TTI2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022807001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTI2"/>
    <dbReference type="FunCoup" id="A0A068TTI2">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTI2"/>
    <dbReference type="Gramene" id="CDO98643">
        <property type="protein sequence ID" value="CDO98643"/>
        <property type="gene ID" value="GSCOC_T00022807001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTI2"/>
    <dbReference type="OMA" id="QENYSHE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTI2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="56124" checksum="6B586587664528CF" modified="2014-10-01" version="1">MNDDDGNFADKLHKIVVDYSKPEFKMEEALDRACVKLTTPMVVEVLHRLRYEEKTAFRFFTWAGHQEHYSHEPQAYNEMMDILSSTKYKVKQFRIVCDMLEYMKRNNKNSVPVEVLLNMLRQYTEKYLTHLQKFARKKKIRVKTQPEINAFNLLLDALCKCSLVEDAEAMFRRVKSKIKPNADTYNTLFFGWCRVRNPSRGMNILDEMIKMGHTPDSFTYIAAMDTFCRAGMLTEATELLEFMRTKGTTMSSPTAKTYSILIVALIQSDRMEECFKVVREMIDSGCLPDVSTYKEVIEGMFLGGKIEAAYKFLEEMGNGGFPPDIVTYNCFLKVLCDNKDSKEAIRLYENMINVGCVPSVQTFNMLILMFFRMGDIDGAFETWHEMDQRGCKRDIDSYCVMIEGLFDSNNMQDACFLLEEVVKRGMKLPFRTFDSFLKKLSAVGDLQAIHRLSEYMRKFYNPAMARRFALNQKRKSMRLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUY8</accession>
    <name>A0A068TUY8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">XS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029900001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUY8"/>
    <dbReference type="FunCoup" id="A0A068TUY8">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUY8"/>
    <dbReference type="Gramene" id="CDP00105">
        <property type="protein sequence ID" value="CDP00105"/>
        <property type="gene ID" value="GSCOC_T00029900001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUY8"/>
    <dbReference type="OMA" id="DCDHDEK"/>
    <dbReference type="OrthoDB" id="1892195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUY8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080188">
        <property type="term" value="P:gene silencing by siRNA-directed DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12266">
        <property type="entry name" value="RRM_like_XS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2890">
        <property type="entry name" value="XS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045177">
        <property type="entry name" value="FDM1-5/IDN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005379">
        <property type="entry name" value="FDM1-5/IDN2_XH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005380">
        <property type="entry name" value="XS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038588">
        <property type="entry name" value="XS_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005381">
        <property type="entry name" value="Znf-XS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596:SF65">
        <property type="entry name" value="PROTEIN INVOLVED IN DE NOVO 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03469">
        <property type="entry name" value="XH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03468">
        <property type="entry name" value="XS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03470">
        <property type="entry name" value="zf-XS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657347" description="XS domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger-XS" evidence="7">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XS" evidence="5">
        <location>
            <begin position="136"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Factor of DNA methylation 1-5/IDN2" evidence="6">
        <location>
            <begin position="524"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="279"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="76023" checksum="C1ABB9027AB52294" modified="2014-10-01" version="1">MREAQVLVRFIFVSLNVMGGSVDHSSGEDTDISESEIEEYEDKSYQALKSGKKEVKVSDGAFTCPYCPKKRKADFLYKDILQHASGVGSSTSKKRSARDKANHLALAKYLEKDMSVTAGPSQATVEVDPLADHDRDEMFVWPWIGIVVNLATDFKDGRYVGKSGSNLRDELTSRGFNPTRVRPLWNYQGHSGTALVEFTKDWFGFKNAMSFEKAYEADRHGKRDWMANNTLKSDLYAWVARVDDYKSDGIIGENLRKIGDIRTISDIIEEEVRKTSKLVNNLTNVIEVKNMQVKEMESKFQETESSLGILIEEKNKLHQAYNEELKKLQSTAREHFQKILSDHEKMKSQLENQKKELELRGKQLEQREAKNESDRKKLLEELEENAAQNSLIDAASEEQRKVDAKVLKLAEEQRKQKEELLNRIIQLEKDLDTKQALQLEIERLKGTINVMKHMGDEGDLEVLQKADSLNKLLREKEGELEDFDRLNQTLIVKERKSNEELQDARKELINGLKEYPNSAYIGIKRMGELDNKPFYEAMKLKYKHEADAEERASELCSLWDEYLKDPEWHPTKVILVNGKHEEVIDEDDEKLNDLKEKYGHEVYKAVTTAFIEINEYNASGRYITSELWNYAEGRKATLKEGAAFLLKKWKLHMEKMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV62</accession>
    <name>A0A068TV62_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026263001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV62"/>
    <dbReference type="FunCoup" id="A0A068TV62">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO99198">
        <property type="protein sequence ID" value="CDO99198"/>
        <property type="gene ID" value="GSCOC_T00026263001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV62"/>
    <dbReference type="OMA" id="SAWQAFN"/>
    <dbReference type="OrthoDB" id="529675at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008637">
        <property type="entry name" value="HR_lesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474">
        <property type="entry name" value="HR-LIKE LESION-INDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31474:SF4">
        <property type="entry name" value="NICOTIANA LESION-INDUCING LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05514">
        <property type="entry name" value="HR_lesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="157" mass="17644" checksum="984EAAF99665D880" modified="2014-10-01" version="1">MGFFSFLGRVLFASIFILAAWQMFNEFGDDGGPAARAWAPKLVPIQKFLRSKFGEGGPNIDVRHFVAGSIALKGLGGLLFVFGSKMGAYLLMYHLLYTTPLFYDFYNYEFGGPEFFSHLQDFLQCVALFGALLFFLGMKNSILRKQLKKKTPKPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVS6</accession>
    <name>A0A068TVS6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chalcone-flavonone isomerase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00026626001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a chalcone = a flavanone.</text>
            <dbReference type="EC" id="5.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; flavonoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the chalcone isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVS6"/>
    <dbReference type="STRING" id="49390.A0A068TVS6"/>
    <dbReference type="Gramene" id="CDO99448">
        <property type="protein sequence ID" value="CDO99448"/>
        <property type="gene ID" value="GSCOC_T00026626001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVS6"/>
    <dbReference type="PhylomeDB" id="A0A068TVS6"/>
    <dbReference type="UniPathway" id="UPA00154"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045430">
        <property type="term" value="F:chalcone isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009813">
        <property type="term" value="P:flavonoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044164">
        <property type="entry name" value="CFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28039:SF8">
        <property type="entry name" value="CHALCONE--FLAVANONE ISOMERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28039">
        <property type="entry name" value="CHALCONE--FLAVONONE ISOMERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02431">
        <property type="entry name" value="Chalcone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0284">Flavonoid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="62" mass="7029" checksum="FF2C007A7B51F9BE" modified="2014-10-01" version="1">MAQSPSVSEVRVEDHELNESIEFFRDIVTGPSEKFARLNLLQPLTGQEFSKKVAENCTAYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVU3</accession>
    <name>A0A068TVU3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032349001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVU3"/>
    <dbReference type="FunCoup" id="A0A068TVU3">
        <property type="interactions" value="1063"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVU3"/>
    <dbReference type="Gramene" id="CDP00415">
        <property type="protein sequence ID" value="CDP00415"/>
        <property type="gene ID" value="GSCOC_T00032349001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVU3"/>
    <dbReference type="OMA" id="PTWSMIE"/>
    <dbReference type="OrthoDB" id="1908944at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVU3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46872">
        <property type="entry name" value="DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46872:SF5">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="247"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="467" mass="52160" checksum="01E46EF4C7F8C678" modified="2014-10-01" version="1">MGVKRPFDEEDFQVSSVKQAKQLEFDNKQTSFSKAFSSDDVSQNSGSRGDFDKCQLFKELGNEDSRSASSSAEKELETSAPLSWVTSSSGEEDAGSGEPFYVSLFPEYFEFNFPRRTVVHLEDSYSSLINSSPRKQIPIGPNHQAEIPPWDPQAVETDPLTPNNCVRDDNEEAVGTCIISASLSSYSSRDEVKIGQGRKDCVCLDRGSVRCVRQHIKEAREKLREVIGDEKFLELGFYDMGEEVAAKWTEEEERVFHEVVYYNPVSLGKNFWKQLAVAFPSRTSRDLVSFYFNVFMLRRRAVQNRSNLLEIDSDDDESQGNDGGFFRVVGEDEDSVVESLGDQDVQEGSEDDIPSDDEDDAGDGDDDDDDDSDDGNGDSEVGRDGGVGAERGDAIGMGDLRGQILKPQIDILHNDFRSDHLPGMFHLRDARENHNFQEDCILAKGFDLLPTCNIIEEIFGPCTSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWL3</accession>
    <name>A0A068TWL3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00032387001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWL3"/>
    <dbReference type="FunCoup" id="A0A068TWL3">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWL3"/>
    <dbReference type="Gramene" id="CDP00447">
        <property type="protein sequence ID" value="CDP00447"/>
        <property type="gene ID" value="GSCOC_T00032387001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWL3"/>
    <dbReference type="OMA" id="APVHDFV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWL3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002859">
        <property type="entry name" value="putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="85"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="306"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="743" mass="83930" checksum="9D26EF495BC5D692" modified="2014-10-01" version="1">MMVGRLYQLLFSLVTFHSRDFFSDIFSFLGKSFPFLTVLLGWGLFFGTRVLFYSFVVKRASYIASMHVGSANSICFLIEVEKLLVEEVRNNNTLIVVGETGSGKTTQLPQYLFYGGFCRDGGVIGITQPRRVAAVSVAKRVAEECGVALGQKVGYAIRFDDMTSASTRIKYMTDGLLLREALLDPCLSKYSVIIVDEAHERTVHTDVLLGLLKSVQKTRSSVSKVMNGHAQNGLLMGAENDKSFLMPCHGKKLSPLKLIIMSASLDARVFSEYFGSARAVHVQGRQYPVDILYTHQPESDYLDAALITIFQIHLEESHGDILVFLTGQEEIESVERLVHERLRQLPEGNQKLLTFPIFSSLPSEKQMKVFMPAPPGFRKVSLDCTKMNVRKTNPLWISTTEYGCGQKLWFHQQAKVVIGRTLQLAKVNKLYCSGRAGREGPGKCYRLYPESEFDKFEDSTTPEIKRCDLSNVILQLKALGIDDIAGFDFIDKPNRTAIIRSLEPLFLLGALTEESKLTDIVGHQMARLPLEPVYSKALILSSQLNCLEEMLIVVAMLSVESIFYAPREKLEESRAALRCFSSPEGDHLTLLNVFHASNEFVVKNKLTHSKEKAEKNLRKWCKDNFINSRSLRHARDVHSQIQRNVEQMGLRITSCGDDMLVFRRCLAASFFLNAALKQPDGMYRILSSGLMVQIHPSSILFRSKPECIIFDKLVRTNNNYIRNICRIDYLWLPELAPQCYGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWL6</accession>
    <name>A0A068TWL6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00032394001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription. Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWL6"/>
    <dbReference type="FunCoup" id="A0A068TWL6">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWL6"/>
    <dbReference type="Gramene" id="CDP00452">
        <property type="protein sequence ID" value="CDP00452"/>
        <property type="gene ID" value="GSCOC_T00032394001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWL6"/>
    <dbReference type="OMA" id="MKDALWA"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWL6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000427">
        <property type="term" value="C:plastid-encoded plastid RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009662">
        <property type="term" value="P:etioplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042793">
        <property type="term" value="P:plastid transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01167">
        <property type="entry name" value="bac_FRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000021">
        <property type="entry name" value="Fructokinase-like 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050306">
        <property type="entry name" value="PfkB_Carbo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085:SF2">
        <property type="entry name" value="FRUCTOKINASE-LIKE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085">
        <property type="entry name" value="HEXOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="233"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="572" mass="63913" checksum="870D8CD1CE4BAAC1" modified="2014-10-01" version="1">MAHLSFSQFSSLPRWQSSWTFFPNSNMKFSELHYTGLESRWHLAAVSKRKVTQALAQEASEEGDVVEKETRPKSKRATATTRKKGATENTENGSVSVVDGNPADEENMTTSGSSETTKKTRRRTRKKDTLATNNLEAEAANKKVTRRRRTKKQIDNAVDQDSAMEFSDQEGDAFIADTDSEQEMELDLDEGEDISFTYGWPPLVCCFGAAQHAFVPVGRRSNRLIDHEMHEIKKDAIWAPEKFVRSPGGCASNVAVALACLGGKVAFMGKLGDDAYGQSLLYFLNLNKVQTRSVRIDSKRVTAVSQMKIGKRGGLRMTCVKSCAEDALLTSEINIDVLKEAKMFYFNTFSLLDWKMRSTALQAIKISKKLGGIVFYDLNLPLPLWQSGEETKTFIQKAWALADVIEVTKEELEFLCGIKASEEFDTKNNDRSKFTHYAPEVVAPLWHENLKVLFVTNGTSKIHYYTKEHNGSVLGMEDGPLTPYTSDMSASGDGIVAGILRMLTVQPHLLTDKGYLEHTIKYAISCGVIDQWLQARKLGYPAKEGMEDDVIPDSNGIRSITEKEFRTLVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX12</accession>
    <name>A0A068TX12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein RIX1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00029616001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX12"/>
    <dbReference type="FunCoup" id="A0A068TX12">
        <property type="interactions" value="1373"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TX12"/>
    <dbReference type="Gramene" id="CDO99903">
        <property type="protein sequence ID" value="CDO99903"/>
        <property type="gene ID" value="GSCOC_T00029616001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX12"/>
    <dbReference type="OMA" id="CESIIHP"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO99903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="847" mass="92344" checksum="5C816259CB27E834" modified="2014-10-01" version="1">MHVYNCLKVIDCKIILKQKQLLYTLLEVPDKSWAGIYLLGLTSQECSSERFLASYSEWFNKILSHIQPPSDSHFVRVASCASMSDLFTRLGGFPNAKKDGNSQASKLIQPVLKLLNEDSSDAFWEEAISLLCTLTNAFPSSLSRHYDNVESSIFSKFMSENCPFSIFKKLAHGLALLPKSRGDEDSWSLMMQKVLIFINNQLNVMFQGLEEEARSSEVVRLLLPPGKDPPPPLGGLTASAKISDQAMKRPEQVLVSRVSTLMTCCCTMLTDAYPVQVSVPVRSLVALVKRVLMVDGSFSQSSPFMTAMRQDLICLELPELHRCSLELLSSIVKGLRSQLLPHVADITRLLTEYFRTCTLPELRIKVYSIMKVLLMSMGIGIAIYLIQEVISNVLLDLDPHGHESGGSYSAAHSKTLEEALQQSFQRKRKHPTSAESVGDQSVKGGLEVETSQNMTAISVRIAALEALEALLNVAGAMRSDGWRSNIDRLLITVATNACKVGWADNNSTVVYGEATPIWADFQLAALRALLASLLSPGRVRPPHLAQGLELFRRGSRESGTKISEYCCHALLTLEVLIHPRALPFIDLQSAVDHYGSASLNLPEVHSADHRKSTSFHFSTQGKQPAQPESGDDDLYERWLAIGDETDVNDPGKYTSSDKEPSGASTHPALEKLPHGDSPSERNKRECGEFGESMAVAADKVPVDGDEIMVDLLTQESYKQTEERDHIEGQISVATAGGHTATKSDGLVSGSATSADGHTDFVVAAGKDVSSSASKRNTMAMATEQCVAPTTSAKDVVTSQDDEYTRIVEKISATISNTGRGAGVVVEISDDASMDSLPDIVDGDPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXF8</accession>
    <name>A0A068TXF8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00029820001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXF8"/>
    <dbReference type="STRING" id="49390.A0A068TXF8"/>
    <dbReference type="Gramene" id="CDP00048">
        <property type="protein sequence ID" value="CDP00048"/>
        <property type="gene ID" value="GSCOC_T00029820001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXF8"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXF8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="2-oxoglutarate dehydrogenase E1 component N-terminal" evidence="16">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP00048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="307" mass="35306" checksum="2465F5542199232C" modified="2014-10-01" version="1">MAWFRAGSNAAKLAIRRTLSQGGGSCVSRTRVVPLQNRYFHTTVSRSRAQSAPIPRPVPLSKLTDSFLDGTSSVYLEELQRAWEQDPNSVDESWDNFFRNFVGQAATSPGISGQTIQESMRLLLLVRAYQVYGHLKATLDPLGLEQREIPDDLDPALNGFSEADLDREFFIGVWRMSGFLSENRPVQTLRAILTRLEQAYCGAIGYEYMHIADREKCNWLRDRIETPTPMEYSRDRREVILDRLMWSSQFERREPHCMFFKLLSRDSPPSLSKLFSSLNCPLKKSMNMFKCHLCCTLQFQNILQVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXP6</accession>
    <name>A0A068TXP6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032925001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXP6"/>
    <dbReference type="FunCoup" id="A0A068TXP6">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXP6"/>
    <dbReference type="Gramene" id="CDP00827">
        <property type="protein sequence ID" value="CDP00827"/>
        <property type="gene ID" value="GSCOC_T00032925001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXP6"/>
    <dbReference type="OMA" id="LCARDHI"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXP6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000003">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF39">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="129" mass="14654" checksum="4D034DE0720655B7" modified="2014-10-01" version="1">MEAAEAELERRSKFLNSLILKKKAVEQKEQHERLNVRLRASDMAVSLQNHAFNCARNNLDSMPKGKLDSKRLALSLKKEFDSTYGPAWHCIVGTSFGSYVTHSTGGFLYFSIDKVYVLLFKTAVEPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZA3</accession>
    <name>A0A068TZA3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036430001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZA3"/>
    <dbReference type="Gramene" id="CDP01397">
        <property type="protein sequence ID" value="CDP01397"/>
        <property type="gene ID" value="GSCOC_T00036430001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZA3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="79" mass="8493" checksum="8B3C77D69799682E" modified="2014-10-01" version="1">METLASSFDETMTFNVVNGGVLTCAGEAVVLLAAALVSALVKTSLVVLTQFSSFISAASILLQKRKEKEKDLLHVEIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZD1</accession>
    <name>A0A068TZD1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00034876001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZD1"/>
    <dbReference type="STRING" id="49390.A0A068TZD1"/>
    <dbReference type="Gramene" id="CDP01284">
        <property type="protein sequence ID" value="CDP01284"/>
        <property type="gene ID" value="GSCOC_T00034876001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZD1"/>
    <dbReference type="OMA" id="QAITNGC"/>
    <dbReference type="OrthoDB" id="619632at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZD1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000537">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974">
        <property type="entry name" value="OS07G0415500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974:SF3">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654369" description="Receptor-like serine/threonine-protein kinase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="21">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="506"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP01284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="796" mass="89306" checksum="49A7D4F950E29723" modified="2014-10-01" version="1">MATLLRFLLSSLLLSLPLPSFSRTYTSLTKGSSLSTRDFLVSTPDAIFAAGFFSVGENSYCFSVWFAERYGDNHTIVWMANRDQPVNGQHTKLILQNSGNLELTDAGQLLVWSSATESSSSVQLELHDNGNLILSTSDGQNLWQSFDSATDTLLPEQLFTRNSILVSSRSKTNYSSGFYKLYFGSDNVLHLRYEGPEITNVFWPDPTLVIWTAGRSTYNSSKVAMLNSSGYFLSSDTLQFNTSDCGVRLQRRLVMDVDGNLRVYSLDKATQSWQVTWQQSSEPCSIPGICGANSICSSAPDSERKCTCLPGYKMNNLTDWSNGCEPDFKLSCNDTVSSGFVQLLNVQYNGYDLGSFTNYTFESCKNLCLSYCECKGFQYTFDLVNGYYSCKPKTILFNGYRSGDFPDPMYIRVPTINLNTIKPSRDLNLQCTAQITPLDRTYERKNQDWVKSFLWCTLAIGAFEIICLFTYFFKTQRRSSAKIQGYLQVATGFRKFSYAELKKATRNFSEEIGQGGGGVVYKGMLSDNRVAAIKYLKEAIQGEAEFLAEISTIGRLNHMNLIEIWGYCAEGKHRLLVYEYMEHGTLANSLCSDKLDWKKRYEIALGTARGLAYLHEECLEWVLHCDVKPENILLNSGYQPKVADFGLSKLLNRSGIDNLQFSKIRGTRGYMAPEWAFNLPITSKVDVYSYGIVVLELITGRRPTGGNSNDDSSAVEPRRLVSWVKGKMQEADGRGSPTSVMGIVDPGLDGEFDMERMEILVKVALKCAEEDIDARPTMREVVDILLHQESEGAVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZF3</accession>
    <name>A0A068TZF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00034908001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZF3"/>
    <dbReference type="FunCoup" id="A0A068TZF3">
        <property type="interactions" value="2222"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZF3"/>
    <dbReference type="Gramene" id="CDP01309">
        <property type="protein sequence ID" value="CDP01309"/>
        <property type="gene ID" value="GSCOC_T00034908001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZF3"/>
    <dbReference type="OMA" id="HASHDLC"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="218" mass="23953" checksum="B294F89544D5FA15" modified="2014-10-01" version="1">MALWISRRAFRSWNGAFSSALGFSSGLSCQRAVRQSVFSVELSALQKNELLIAACRGFSTSILTPGSCEDAFPSDLLSRKRVFPPERTVGLCQDLVIPVTNFSNEDKGLMVLAGDVFDVPIRKDIVHRVVRWQLAKRQQGTHSTKTISEVSGTGRKPWRQKGTGRARHGTLRGPQFRGGATMHGPKPRSHAIKLNKKVRRLGLKIALSARAAEGKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZH1</accession>
    <name>A0A068TZH1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">COBRA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00032805001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COBRA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZH1"/>
    <dbReference type="STRING" id="49390.A0A068TZH1"/>
    <dbReference type="Gramene" id="CDP00738">
        <property type="protein sequence ID" value="CDP00738"/>
        <property type="gene ID" value="GSCOC_T00032805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZH1"/>
    <dbReference type="OMA" id="DNWHLSW"/>
    <dbReference type="OrthoDB" id="2014623at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZH1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010215">
        <property type="term" value="P:cellulose microfibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056900">
        <property type="entry name" value="COB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006918">
        <property type="entry name" value="COBRA_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31052">
        <property type="entry name" value="COBRA-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31052:SF24">
        <property type="entry name" value="COBRA-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25079">
        <property type="entry name" value="COB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04833">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="COBRA C-terminal" evidence="10">
        <location>
            <begin position="421"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="660" mass="72625" checksum="7764AAC3C15B0467" modified="2014-10-01" version="1">MAKIFSFLNHIILPLLIIVTISLPTSISQLQEPTNTPYGVCNGVVIQYNYDTGYQIPPTLLPGAPDNQPYRFESTLTVLNAGFEELKNWKVFVGFQHNEYLYSASEAVLDDGTSLPGNVSQGAVFSGSPVTDLKTSVETAGDLNQMMARVELVGTQFGVAPPNAPLPSNLSLANDGYLCSGSNMPQGVNLTQVCCIRDLNARSNITTEQESPLESGDISIMYDVTSAYETNYRAQVTISNENPISRLDYWKLTWEWMREEFIYQMKGAYPTVLDTKECVFGAQGEYYKDLDFSIAVNCERRPTIIDLPPDRTNDTKLGMIPFCCRNGSLLPPTLDPTRSKSAFVMQVYKMKPDLNRTQIYPPLNWKINGTSGPEYQCGQPVRVSSSFFPNPQGLSSDVSAVASWQIVCNISQAQTPQKKPNCCVSFSSFSNDSVVPCNTCACGCNLNPSNMCNATAPALLLPPDALLVPFDNRTKKAIEFSKLKHRHLPNPLPCGDNCGVSINWHLLSDFEDGWTARITLFNWGDTSIADWSAAVELDKAMPGFEAVYSFNGTIIPDSNNTLFLYGHPGLNYLVAETEARKPRKDPPIPGSQQSVILFTKKETPGINVARGDGFPSKVYFNGEECSLPTRLPISFTHRLSAASASITILLSLFVLMAVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U057</accession>
    <name>A0A068U057_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037096001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U057"/>
    <dbReference type="STRING" id="49390.A0A068U057"/>
    <dbReference type="Gramene" id="CDP01915">
        <property type="protein sequence ID" value="CDP01915"/>
        <property type="gene ID" value="GSCOC_T00037096001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U057"/>
    <dbReference type="OMA" id="IKWECPL"/>
    <dbReference type="OrthoDB" id="1928519at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U057"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33400:SF2">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33400">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="521" mass="56924" checksum="074A760D68A50E9B" modified="2014-10-01" version="1">MYITVLFTYLSDPIHSSPRLLLVQAKFFQSEDCLSEVGREPPGNPHEKVSNENIAIADGFPGSSVGSYPNPLSHKGVSHIPQIPWRTPPRQFDLKFECHVAAGEESEEVEVQKHREMRVHEAVYPHFSAVPHCPSISSDVEAEHFDDWHTPVIPVTAIEEAAETDCLAKPEPAKLPQSPSTSEIFDIPQCKSLLSRELSKGKKSDHAPLQDLDGPMVAAAAATTAIMKSKEPPSLIDPELLIKLLSNPELVQKLIAERRLASDTTTRTSGSKTVDSTIVSLVQKSTTENTHPGNAGIEAVLRPGNQPLAVKAETGTGLGPKQVTTSISLLSSKSDLPSQNSNYEVFQRADVGNMSLLKASRALSSSIPDVLTEVYRLKKLIEEHGSHDRAGNDYVGEIPAPSSIFLTISCCAFSCSLTTTSLSLQKDISYFQSLIRQHGEEKGSQDDELSLYGISHNHLQSKESDRKYKRTCKFYNSSMGCRNGSSCPYEHDVPGQWRSDVVLEAPGAKRLKLGGSFTGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2L4</accession>
    <name>A0A068U2L4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00040195001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2L4"/>
    <dbReference type="FunCoup" id="A0A068U2L4">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2L4"/>
    <dbReference type="Gramene" id="CDP02721">
        <property type="protein sequence ID" value="CDP02721"/>
        <property type="gene ID" value="GSCOC_T00040195001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2L4"/>
    <dbReference type="OMA" id="SCSYAKW"/>
    <dbReference type="OrthoDB" id="4788989at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2L4"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16571">
        <property type="entry name" value="RING-HC_SIAHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044286">
        <property type="entry name" value="SINL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46632:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46632">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
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            <begin position="60"/>
            <end position="103"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
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    </evidence>
    <sequence length="383" mass="42998" checksum="4DAB9DEA886BFBD9" modified="2014-10-01" version="1">MARFSLGDEADERERSDPSSSSSRPTPKRQKLTVSPQPQPSQPAVDAPIQTNDLVQVVEGDAEEEEEEESEYEIEAEEEGSEYEDQEEEDDDEDDDDDQEEDDRILQPQPEVNGDGNRDGPISVTLTDPDVLDCPICIEPLSIPVFQCENGHIACSSCCLKIRNKCPSCSWPIGYNRCRAIEKVLESVKVSCRNIKYGCTQMVRYCNKHEHENTCILAPCSCPLLDCNFVGSAWQLYSHFKLRHPASGNTFLLGKPFSISLEKSQRSIILREGDGNIIFILNHFNERHGSAINIVRIAPLGSGTRFSYDLTVRDGDTSIRLQSSVESIRKWVDSAPAKKFLLVPCYYYTSNCGQLELDVCIRAEQSCSRSSGNNMKFLFTRAD</sequence>
</entry>
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    <accession>A0A068U2V5</accession>
    <name>A0A068U2V5_COFCA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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                <person name="Lepelley M."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Perrotta G."/>
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                <person name="Rouard M."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000295252"/>
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    <sequence length="136" mass="14699" checksum="D0D36A995080D363" modified="2014-10-01" version="1">MTQIKYTWLASSGQDPANSSDSEKKAQMKCLVSLSLVLSLLLLFQCFLTSALDQTVSDLPDEVLVHKSLKQQQGKQLGIGKHDSIGIRKLGVVIKARRGQRFITSGGRASSTRSSAATGKELSLSKLPVLLLLPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U350</accession>
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            <taxon>Coffea</taxon>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
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        <text evidence="6">Probable transcription factor.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00040159001"/>
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    <dbReference type="OMA" id="EIKFWQN"/>
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    <dbReference type="PhylomeDB" id="A0A068U350"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TF_MADSbox"/>
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    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MADS_BOX_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="K-box" evidence="8">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037260"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP02692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25400" checksum="B413B48B8BB90CFB" modified="2014-10-01" version="1">MGRGKIVIRRIDNSTSRQVTFSKRRNGLLKKAKELAVLCDAEVGVVIFSSTSKLYEYANTSMKSVLERYSKAKEERHQLLSPPSEVKFWQREATILRQQLHNLQEIHRQLMGEELYGLSVKDLQGLENQLEMSLRGIRMKKEQILTDEIRELHRKGCLIHQENVELYKKAYSTTNSNATHGNTITPYGFAITEEQHAPIHLQLSQPESQNFVTSEGTSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U367</accession>
    <name>A0A068U367_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00041394001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U367"/>
    <dbReference type="STRING" id="49390.A0A068U367"/>
    <dbReference type="Gramene" id="CDP02956">
        <property type="protein sequence ID" value="CDP02956"/>
        <property type="gene ID" value="GSCOC_T00041394001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U367"/>
    <dbReference type="OMA" id="IYLMAGQ"/>
    <dbReference type="OrthoDB" id="1720978at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U367"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000090">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="244" mass="26827" checksum="AE404577F25959C0" modified="2014-10-01" version="1">MKLYCFVVIHGAGGMEMIDPLFQRILVKECQSRKIPVIFDEVFTGFWRLGVESAAKLLCCQPDISCFAKLMTGGVVPLAVTLASEAVFEAFVGESKLKALLHGHSYSAHAIGCSAAVQSIKWFKNSQRNVNLIPGADLLRELWDTELVHQLSSHPAVKRVVTIGTVCALELRAEGCNAGYASLYATSLLKKIREDGIYTRPLGNVIYLMCGPCTSPQVCSQTMNKLIRRLDEFSEVKNVEACQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3W4</accession>
    <name>A0A068U3W4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041716001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3W4"/>
    <dbReference type="FunCoup" id="A0A068U3W4">
        <property type="interactions" value="2336"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3W4"/>
    <dbReference type="Gramene" id="CDP03210">
        <property type="protein sequence ID" value="CDP03210"/>
        <property type="gene ID" value="GSCOC_T00041716001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3W4"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3W4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF52">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL31X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13875" checksum="B403B625B66B367F" modified="2014-10-01" version="1">MVDKTKGRKEEVVTREYTINLHKRLHGCTFKKKAPKAIKEIRRFAQKAMGTTDVRVDVKLNKCVWSRGIRSVPRRVRVRIARKRNDDEDAKEELYSLVTVAEIPLEGLKGLGTKIIEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U419</accession>
    <name>A0A068U419_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039725001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U419"/>
    <dbReference type="FunCoup" id="A0A068U419">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U419"/>
    <dbReference type="Gramene" id="CDP02363">
        <property type="protein sequence ID" value="CDP02363"/>
        <property type="gene ID" value="GSCOC_T00039725001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U419"/>
    <dbReference type="OMA" id="DKAHPRC"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U419"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000670">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001086">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g33170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000669">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g33990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000780">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF406">
        <property type="entry name" value="REPEAT (PPR) SUPERFAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="97529" checksum="DF6484D934896F90" modified="2014-10-01" version="1">MASLICRTRRFLVPTKPSFSSYLALYTFPISTVSAVAPANYWKTFSHIFQECSKERALDPGMQSHARMLTTGFKPSIFVSNCLIQMYVRCSYLHYANKVFDNMSQRDTVSWNTMIFAYCSTDIAMAQSFFGLMPERDVISWNTLISGYLQNGDYRKAAEIFVGMQRESVASDGTTFAVVLKACSGLEDYELGIQVHSVVVKVGFDHDVVTGSALVDMYGKCKTLDECFQFFGELPNKNWVSWSAAIAGCVQNDELVGGLKLFRRMQREGVGVSQSTYASVFRSCAALSEVQLGSQLHGHAIKNNFGYDVIVGTATLDMYAKCGNLYYAKQIFDLLPNRSLQSHNAIIVGYARGDCGYEALNVLKLLLKSNLGFNEISLSGAFSACAVIKGLKEGTQIHALATKSPFSSDVCVANAILDMYGKCGALVEARCTFDEMEVRDAVSWNAVIAAYEQNRNEEETVLLFVSMLKHGMEPDEFTFGSVLKACAGQQALNHGMEIHSLIIKSGMGLESFIGSALVDMYCKCGKVGEAEKLHGTMDEQTIVSWNAIISGFSSHEQSEEAQKFFSMMLEMGAKPDNFTYATVLDACANLATVELGKQIHAQIIKQELQTDVFITSTLVDMYSKCGNLQDCRLVFEKATNCDFVTWNAMVCGYAQHGLGEEALEIFKKMQLKDVKPNHATFVAVLRACAHIGLVEEGLHYFKSMQVDYGLDPQLDHYSCMVDILGRSNRVTEALKLIQEMPFEADDVIWRTLLSICKMKGNVEVAEEAAASLLQLDPQDSSTCVLLSNIYADAGMWEGVSRLRKVMRHGHFKKEPGCSWIEVKSEVHMFLVGDKAHPRCAEIYNSLTALIDEMKWAGCVSDGDGMEDDYVACCHASTFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U578</accession>
    <name>A0A068U578_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00016086001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U578"/>
    <dbReference type="STRING" id="49390.A0A068U578"/>
    <dbReference type="Gramene" id="CDP03651">
        <property type="protein sequence ID" value="CDP03651"/>
        <property type="gene ID" value="GSCOC_T00016086001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U578"/>
    <dbReference type="OMA" id="MAARIMS"/>
    <dbReference type="OrthoDB" id="911994at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U578"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000001">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000528">
        <property type="entry name" value="Plant_nsLTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00382">
        <property type="entry name" value="LIPIDTRNSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654573" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP03651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="18163" checksum="FECCB4403F5FA3C7" modified="2014-10-01" version="1">MASKRTETCLVLVLVLMLSLWSGAKAQSVSSCASTLVGLSPCLSYVTGNSSTPSPACCTQLAGVVQSAPRCLCTLTNGASNFMGLNINQTLALALPGACNVRTPPISQCNSAANGPASSPASSPAAAPAATSPASPSAGAPKTTPERTASKAVPAAPGSTSDGSLVKPALFLLLAALASTAVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U640</accession>
    <name>A0A068U640_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00016217001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, TIMM44 and TIMM14. The complex interacts with the TIMM23 component of the TIM17:23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U640"/>
    <dbReference type="FunCoup" id="A0A068U640">
        <property type="interactions" value="2899"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U640"/>
    <dbReference type="Gramene" id="CDP03742">
        <property type="protein sequence ID" value="CDP03742"/>
        <property type="gene ID" value="GSCOC_T00016217001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U640"/>
    <dbReference type="OMA" id="HTVFYLW"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U640"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015462">
        <property type="term" value="F:ABC-type protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000005">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="12">
        <location>
            <begin position="337"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP03742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="496" mass="56488" checksum="8E52A5637D9C86F7" modified="2014-10-01" version="1">MASKKLVRDLFIARQPLFRQLLAPQMVSSGATRLRLTTQVNGFGVRRQFSVFNEFSNKIKGEASKNQDFQQSVKELKEKAEELKGVKEDLKARTKQTTEQLYKHVDGVWTEAESTAKKVYTDVEEKISAAKAEVKESFGFRKEESSESTGASENIHSDGKDGGEMRFGEQKQQEQHQQSGPSNNAGAFFDKFKSGVSSVSAKASMAFQKVKEAKPIDIVKKGYDIVKDELQGNAVKRKHLEHSPQTADPSIKVGKSTRTDLVILPSKQSKWGKKWDTFMEKMRGHPLYKRVRGMSEPVVTKSQEIAEDVRERWDTSDHPVVHKIQDLNETVFGETDTAMSFKEIRQRDPSFSLPEFVSEVQEVVKPVLNAYFKKDFEVLKKYCSSEVVERCKAEHNAFESQDIFFDHKILHISDVEVRETKMMGDSPIIIVTFQTQQIYCVRDRHGAVTEGGKDTIHTVYYAWAMLQVPPEELGEGAIYPIWRLREMQQFGVQALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6F2</accession>
    <name>A0A068U6F2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00016207001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6F2"/>
    <dbReference type="SMR" id="A0A068U6F2"/>
    <dbReference type="Gramene" id="CDP03734">
        <property type="protein sequence ID" value="CDP03734"/>
        <property type="gene ID" value="GSCOC_T00016207001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6F2"/>
    <dbReference type="OMA" id="PAYRTMT"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6F2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="190"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP03734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="342" mass="38156" checksum="3400FBA4881930C8" modified="2014-10-01" version="1">MEQPRVLRWFDVQSVPGDYRFPLEDRPGRLPIPLCDAVPVIDLHKSTTSPEKWSMVRQIVEASQEYGFFQVINHGVSEDVVRETSTVFKEFFNMYAEGKKGTSASDGDLSRGWIYMNSSSVFAKDGIHLWRDNVKLACHPLEECMQGWPPKPTRYREVVATYVEEMRRLSGRILELICEGLGLEAGYLERLSQVQLVVGNYYPPCPDPSLTLGLLKHCDPSLITILLQEGNACGLQVLHNGKWIGVAPLPNALVVNIGNQLEIISNGKLKSAEHRAVTNSYEARISIATFINPSHNSIVEPAKVLVDELNPPRYAPTLYKDFAHTSKVASTEATKPPAPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6U8</accession>
    <name>A0A068U6U8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00041891001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6U8"/>
    <dbReference type="Gramene" id="CDP03343">
        <property type="protein sequence ID" value="CDP03343"/>
        <property type="gene ID" value="GSCOC_T00041891001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6U8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP03343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="57" mass="6437" checksum="D182FACEAA9B5CFA" modified="2014-10-01" version="1">MLLVILHKASWCITAVQYHCFLRTEEEERRGGGVVPASSSVTFESYKFFDCFGCLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U727</accession>
    <name>A0A068U727_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00016508001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U727"/>
    <dbReference type="FunCoup" id="A0A068U727">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U727"/>
    <dbReference type="Gramene" id="CDP03989">
        <property type="protein sequence ID" value="CDP03989"/>
        <property type="gene ID" value="GSCOC_T00016508001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U727"/>
    <dbReference type="OMA" id="DSKWTFI"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U727"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP03989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="243" mass="27210" checksum="074C473BC0928E89" modified="2014-10-01" version="1">MATLSNQGKIDISCWDGTISQHEFHTAASAFAERWNKFNAALPQCSWVARPISPYLSSTSKDEGYLSVENVIMFPTPAAESCYGGDDKEGEEELSCSRSQEDDFIDGATMLQNHDDASHHYDFHVVYNASYRVPVLYFRAYCSDGRTLVLDDVEKSIPAISAKLLMLSKWTFITQEDHPYLNCPWYTLHPCGTSEWMKMLFSHEPAVDDGGVAVAKYLVSWFSVAGQVFGLKIPFEMLSSIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U743</accession>
    <name>A0A068U743_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016529001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U743"/>
    <dbReference type="FunCoup" id="A0A068U743">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U743"/>
    <dbReference type="Gramene" id="CDP04004">
        <property type="protein sequence ID" value="CDP04004"/>
        <property type="gene ID" value="GSCOC_T00016529001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U743"/>
    <dbReference type="OMA" id="QNGQRQF"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U743"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021374">
        <property type="entry name" value="DUF2996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36341">
        <property type="entry name" value="DUF2996 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36341:SF3">
        <property type="entry name" value="DUF2996 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11210">
        <property type="entry name" value="DUF2996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="210" mass="22443" checksum="9267D905E7AB634A" modified="2014-10-01" version="1">MAATAGGSIAVSSFISSSNFSQKAKPTSTLSLSMVTSKSLITSRRVACSAVQESSAAAAAVAAETKEEEEEKQKEGTKEAATAKATAPAAKKPPAKAPPKPLPQLMEEEVIPSLTATLEAQEDITQLELSFQDNKLEGSFLKKGFPYSFWAFFPDGNLTGPRGFSLSSYGSGVSTVEPFLVDEKRITAKHVVFWVRKRLAAQGIIPVWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U787</accession>
    <name>A0A068U787_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Senescence regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017784001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U787"/>
    <dbReference type="STRING" id="49390.A0A068U787"/>
    <dbReference type="Gramene" id="CDP04405">
        <property type="protein sequence ID" value="CDP04405"/>
        <property type="gene ID" value="GSCOC_T00017784001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U787"/>
    <dbReference type="OMA" id="ADWGGFL"/>
    <dbReference type="OrthoDB" id="1917735at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U787"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33083:SF103">
        <property type="entry name" value="SENESCENCE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21278" checksum="6D25106494BF6419" modified="2014-10-01" version="1">MAEFDTGGDGKESMLEEQDMQEEDVWGAMRERDSSGLKSRKAKESPSACRIPPLPRVVPRVPSGSFDPRAAVELVVHQRHHHPNQSSAPLDISNWSEIYGTSKNSPDINSNSRKGACAVKADDHGRLSADSAKCDDDDDDSEEMIPPHEIVARRMARSPVVSYSMCEGVGRTLKGRDLCTLRNAILAKTGFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7J2</accession>
    <name>A0A068U7J2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00015995001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ARAC5 and ARAC10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7J2"/>
    <dbReference type="FunCoup" id="A0A068U7J2">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7J2"/>
    <dbReference type="Gramene" id="CDP03583">
        <property type="protein sequence ID" value="CDP03583"/>
        <property type="gene ID" value="GSCOC_T00015995001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7J2"/>
    <dbReference type="OMA" id="TRQMNLV"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7J2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000389">
        <property type="entry name" value="Receptor-like cytosolic serine/threonine-protein kinase RBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000335">
        <property type="entry name" value="receptor-like cytosolic serine/threonine-protein kinase RBK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046958">
        <property type="entry name" value="RBK1/2/STUNTED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47987">
        <property type="entry name" value="OS08G0249100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47987:SF12">
        <property type="entry name" value="PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="117"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP03583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="387" mass="43770" checksum="EDBB7F70109C49E4" modified="2014-10-01" version="1">MEKQKETVCSPDTVLEDYLRNLESETDSSKASTSDLGAPKDPKPSSRWAEFLQLFKTKSKRHLSTFHPLKLSKRFSSSLREEIILVPDPMLDTSLNYFKPQWKNFALSDLQTATKSFSQECLVGKGGYAEVYKGSLRDGQLVAVKRLTRGSMEERTGDFLSELGIMAHVNHPNTAKLIGYGVEGGFYLVLELSPHGSLASLLHSAKEKLKWNIRYKIALGTAKGLLYLHESCQRRIIHRDVKAANILLTQDFDPQICDFGLAKWLPRQWTHLTVSKFEGTFGYLAPEFLMHGIVDEKTDVFAFGVLLLELITGRRALDYSQQSLVLWAKPQLKKSRIRELVDPSLAEYDPIEMNLMVLAASLCVQESAIRRPRMSQACLAASERQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8N9</accession>
    <name>A0A068U8N9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">X8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00017986001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8N9"/>
    <dbReference type="FunCoup" id="A0A068U8N9">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8N9"/>
    <dbReference type="Gramene" id="CDP04554">
        <property type="protein sequence ID" value="CDP04554"/>
        <property type="gene ID" value="GSCOC_T00017986001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8N9"/>
    <dbReference type="OMA" id="SIYHICI"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8N9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="X8" evidence="8">
        <location>
            <begin position="287"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="403" mass="43741" checksum="3D77A2301A1E8D63" modified="2014-10-01" version="1">MVGIPNDMLSLLSSSPTASDSWVSQNVSRYMVKNGVNIKYVAVGNEPFLTSYSGQYQSYVVPALTNLQQSLAKANLAGIIKLVVPCNADAYESSLPSQGAFRPELNQIMTQLVSFLNSNGSPFIVNIYPFLSLYGSSDFPQDYAFFDGTTHSVIDGPNVYNNAFDGNFDTLVAALSKIGYGQMPIIIGEVGWPTDGVVSANLSAARAFNQGLINHVLSNKGTPLRPGVPPMDIYLFSLLDEGAKSTLPGNFERHWGIFSFDGQAKYKLNLGNGLLKNAKDVEYLPFRWCVADPSKDLSTVANHFKLACSYADCTTLNYGGSCNDIGAKGNISYAFNSYYQLLKQNVQSCDFDGLGVVTFLDPSVGDCRFLVGITDGKSSGICLDGRLVIVLSLIFWVSYIYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9D7</accession>
    <name>A0A068U9D7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00019775001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9D7"/>
    <dbReference type="FunCoup" id="A0A068U9D7">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04907">
        <property type="protein sequence ID" value="CDP04907"/>
        <property type="gene ID" value="GSCOC_T00019775001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9D7"/>
    <dbReference type="OMA" id="MVCVRIC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9D7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001868">
        <property type="entry name" value="DNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.270:FF:000003">
        <property type="entry name" value="DNA-binding protein SMUBP-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="315"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="540"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="405"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="86328" checksum="4F3E702BCB3901D1" modified="2014-10-01" version="1">MPLGLEAICLKVCTHYPTLFDHFQRELRDVLQDLQRKSVLQDWRQTESWKLLKELANSAQHRAIARKNPQPKSVPGVLGLDLEKVKAIQNRIDDFTKHMSDLLLIERDAELEFTQEELNAVPMPDENSDAAKPIEFLVSHAQAEQELCDTICNLNAVSTSTGLGGMHLVLFRAEGNHRLPPTTLSPGDMVCVRTCDSRGAGATSCMQGFVNNLGEDGCSITVALESRYGDPTFSKLFGKSIRIDRIQGLADAVTYERNCEALMMLQKKGLQKRNPSIAVVTTLFGDSEDVRLLEENHLVDWTEVELNGLLDSKSYDVSQRRAIALGLNRKRPALIIQGPPGTGKTGLLKELIPLAVKQGERVLVTAPTNSAVDNMVEKLCDSGIKIVRVGNPVRISQAVASRSLVQIVNAKLADFQAEIERKKSNLRKDLKHCLEDDSLAAGIRQLLKQLGKTMKKKEKETVREILSSAQVVLATNTGAADPLIRRLDTFDLVVIDEAGQAIEPSCWIPILLGKRCILAGDQCQLAPVILSRKAAEGGLGISLLERAASLHKGIMVTRLTVQYRMNDAMASWASKEMYGGLLKSSSSVSSHLLVDSPFVKPTWITQCPLLLLDTRMPHGSLSIGCEEHLDPAGTGSFFNEGEADIVVQHVYSLINAGVSPTAIAVQSPYVAQVQLLRDRLDEVPEAAGVDVATIDSFQGRESDAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVICDSSTICHNPFLARLLRHIRYFGRVKHTEPGSFGGSGIAMNPILPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBH0</accession>
    <name>A0A068UBH0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Two-component response regulator-like APRR5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00019879001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARR-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBH0"/>
    <dbReference type="FunCoup" id="A0A068UBH0">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBH0"/>
    <dbReference type="Gramene" id="CDP04988">
        <property type="protein sequence ID" value="CDP04988"/>
        <property type="gene ID" value="GSCOC_T00019879001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBH0"/>
    <dbReference type="OMA" id="CKDAYTT"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBH0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17582">
        <property type="entry name" value="psREC_PRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF95">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR-LIKE APRR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="12">
        <location>
            <begin position="637"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="76059" checksum="A765C43EDECF84D4" modified="2014-10-01" version="1">MGEVVVSSDDGGGAMELQVKETEGAAAQTGKGRTNDNIDRSTSSAAATPASSIVRWESFLPKMVLRVLLVEADDSTRQIIAALLRKCNYRVAAVPDGLKAWEVLKGRPHDIDLILTEVELPSISGFALLTLIMEHEICKNIPVIMMSSQDSVSTVYKCMLRGAADFLVKPVRKNELRNLWQHVWRRQAASSAGQGPPDESVAQQKVEATAENNAVSNYSSDYMACIQKNRECFEKGSDAQSSCTKPEQDTEGAEMECMQGLSHPQWSKQSNLNIEQQEGCDNASKKVQASDNGTEGSQEASGKDRGKMAWGEDLNSGVHWERYHVTYHGRDNVKDSAREAIDLIGAFDNYLKCTDRSIGSNAGTNKFDLLPQLDLSLRRSLPSVSVNQIADERHRLNHSDASAFSRYVNRNVQPQPSTSPSTCNQQKEQKSNSDKQLSNHTIDYNSDTHGPTINSQKHVDWAIGQSGESDARFSCPQPRSLPAPIPVRGVRFDRVNNSYGSLIPQAFGTQSGLSSVQPPGSVSHQEVSFGVNAIYQLNHQPGNQQQFSGLMTQNTSDTTDQNENNEGHKVEDRGHVSSATDQSANSSFCNGTVNHLHSLCCGSNEKIDTVPLRSAAECGSEEAFRVQDGNSIRSIQREAALTKFRLKRKERCFEKKVRYESRKKLAEKRPRVKGQFVRQVLNEFPPENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCM7</accession>
    <name>A0A068UCM7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00023066001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + H2O = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21209"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCM7"/>
    <dbReference type="FunCoup" id="A0A068UCM7">
        <property type="interactions" value="2238"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCM7"/>
    <dbReference type="Gramene" id="CDP06300">
        <property type="protein sequence ID" value="CDP06300"/>
        <property type="gene ID" value="GSCOC_T00023066001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCM7"/>
    <dbReference type="OMA" id="ANYFIGF"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCM7"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000003">
        <property type="entry name" value="Phosphoserine phosphatase SerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000114">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP06300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="354" mass="38296" checksum="D68B1EEBEA1EAD57" modified="2014-10-01" version="1">MDPKPICLATSHRQTTPFFAGGISSCGKDPLSERHLIPVPATASPTRVKTPQVFLEGALMEGLISAQLNPIRTHSTQESSVFFPTFSLRIKTIGFGNKLEAMRNLKSDTSINASVQPLEASKEGQFNKALPSKEVLEVWRDADAVCFDVDSTVCLDEGIDELAEFCGAGKAVAEWTARAMSGSIPFEDALAARLSLFNPSIAQVQDFLEKRPPRISPGIDELVKKMKARNTDVYLISGGFRQMINPVASILGIPVDHIFANQLLFGSAGEFLGFDTDEPTSRSGGKAIAVQQIRKANGYKLLVMIGDGATDLEARKPGGADLFVCYAGVQLREAVAAKADWLVFNFKDLVDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDB4</accession>
    <name>A0A068UDB4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00023355001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDB4"/>
    <dbReference type="STRING" id="49390.A0A068UDB4"/>
    <dbReference type="Gramene" id="CDP06486">
        <property type="protein sequence ID" value="CDP06486"/>
        <property type="gene ID" value="GSCOC_T00023355001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDB4"/>
    <dbReference type="OMA" id="TGDSHTE"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000002">
        <property type="entry name" value="isoamyl acetate-hydrolyzing esterase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF10">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="255" mass="28794" checksum="0CCF6BC916CC5473" modified="2014-10-01" version="1">MVGPERPQFVLFGSSIVQFSYSQDGFGAILTDVYARKADILLRGYAGWNSRGALQVLEQVFPKHAAVQPSLVIVYFGGNDSMRPDPSGQGPHVPLAEYVENMKKIAFHLKSLSDKTRVLFLSTPPVNEAQICEFFGRTCDQLCRTNESCRIYSEACIKLCRELDIKVVDLWTALQQRDNWLDVCFVDGIHLSSEASKIVVKEILKVLKEAQWEPCLHWKSLPTEFSEDSPYDVIGPGGDTKNVADLNLHWQIQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDN4</accession>
    <name>A0A068UDN4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst subunit Exo70 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00023591001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDN4"/>
    <dbReference type="FunCoup" id="A0A068UDN4">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDN4"/>
    <dbReference type="Gramene" id="CDP06665">
        <property type="protein sequence ID" value="CDP06665"/>
        <property type="gene ID" value="GSCOC_T00023591001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDN4"/>
    <dbReference type="OMA" id="RFVANYE"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF38">
        <property type="entry name" value="EXOCYST SUBUNIT EXO70 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="236"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP06665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="652" mass="72226" checksum="B7C0A9B503981CDD" modified="2014-10-01" version="1">MPRKPMSTVFASPKASKPSAPPSPSPTRPSFSESVMDRTLELAGPVIAKWSPDTAPFASARVVVTSLFPDNRGEAKRLIKCVNNLQQAMRLLLPENPTSPKLASAQNLMQTAMKTLQREFYQLLSMNRAYLDPESVSSCSTRTSIHSTSDSDSDDDDDEAADSIVQVEDASSLVTADLRLIAECMISSGYAKECVKIYNIIRKSIIDEGVYRLGVEKFSSSSIHNMDWEVLDDRIKKWLDAVKVSVKTLFNGERILSDHVFAASESIRESCFTEISREGAMILFGFPESVVRNSKKSPEKAIRVLDMYTAIATHWPDIKSIFSSESSSTVRSQAITSLAKMGQYVRSDLAEFESAILKERSKSTVAGGAVHHLTIDSMNYLSLLADYSNPLSDILADSPPPPASTTSVLESYSSLSDSGESPAPTISLRFAWLILLLLAKLDGKAKLYKDASLSYLFLANNFQHVITKVRTSNLKHLLGDDWLPKQEVKVRQFAANYKRLAWGHVIESLPEVPAISLTPEEARERFKRFNASFEQARDKQSACVIPDSKLRDDIKVDLSRRILPVYREFYNKHKAVMVGSERDLGSIVRFSPEDVGHCLSDLFFGNVGSGSSSSSSLRSPPSHTRSTKSYTSFVGFTTRYALSFFGSRTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE96</accession>
    <name>A0A068UE96_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00021286001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE96"/>
    <dbReference type="FunCoup" id="A0A068UE96">
        <property type="interactions" value="2522"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UE96"/>
    <dbReference type="Gramene" id="CDP05958">
        <property type="protein sequence ID" value="CDP05958"/>
        <property type="gene ID" value="GSCOC_T00021286001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE96"/>
    <dbReference type="OMA" id="GSHHLGF"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE96"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="71"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="279" mass="32308" checksum="B1ABED29249FA881" modified="2014-10-01" version="1">MEKEESTSSPIQASAPLKINRWKPLCLYYTQGKCTKTDDPVHLGKFNHNLSSGLGLETCQLEKLKSQEFDYFLVLDLEGKVEILEFPVLLLDAKTMNSIDFFHRFVRPSQMGEQRINQYIDGKYGKLGVDRVWHDTAIPFDEVIQQFEEWLGKHHLWVKKPGGRLNRAAFITCGNWDLKTKIPAQCKVSRMALPSYFTEWINLKDIFLNFYNRRAPGMVSMMRELRIPLLGSHHLGIDDTKNIARVVQHMLIDGALLQITARRLRGSPEKVEFLFENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFQ3</accession>
    <name>A0A068UFQ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Auxin response factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00024219001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFQ3"/>
    <dbReference type="FunCoup" id="A0A068UFQ3">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFQ3"/>
    <dbReference type="Gramene" id="CDP07102">
        <property type="protein sequence ID" value="CDP07102"/>
        <property type="gene ID" value="GSCOC_T00024219001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFQ3"/>
    <dbReference type="OMA" id="RHAQFRL"/>
    <dbReference type="OrthoDB" id="1906869at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFQ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010154">
        <property type="term" value="P:fruit development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048366">
        <property type="term" value="P:leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="P:regulation of anthocyanin biosynthetic process"/>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:sepal development"/>
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        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF_dom"/>
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        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF160">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B3"/>
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    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="11">
        <location>
            <begin position="104"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="12">
        <location>
            <begin position="587"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011726"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00023294"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00037697"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004561"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50863"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51745"/>
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        <source>
            <dbReference type="EMBL" id="CDP07102.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="698" mass="76456" checksum="9FF891FEBB12E5CE" modified="2014-10-01" version="1">MKEMVEKSLDSQLWHACAGGMVQMPVVNSRVYYFPQGHAEHTLANVDFAGMPRVPPLILCRVAAVKFLADPETDEVYARIRLVPIGNNEGCYEFDDDADKPASFAKTLTQSDANNGGGFSVPRYCAETIFPRLDYTADPPVQTVVAKDVHGETWKFRHIYRGTPRRHLLTTGWSTFVNQKKLIAGDSIVFLRAESGDLCVGIRRAKRGGIGGPESPSGWNSAAGNYGGFSMFLREDENKLMRTGSAGNLNSPGNGGGALKGRGRVRAESVIEAASFAVKGQPFDVVYYPRASTPEFFVKASSVSSAMRVQWCAGMRFKMPFETEDSSRISWFMGTIAAVQFADPIRWPNSPWRLLQVTWDEPDLLQNVKRVSPWLVELVSNMPVIHLSPFSPARKKLRLLQHSDFSLDGQFPMPSFSGNPLGPSSPLCCLSDNIPAGIQGARHAQLGVQLADLHLSNKMHLGLISPSFQQLDPLAKSSDGITRGHLDSSDDISCLLTMGNSSQKLEKTTSVKTPRFLLFGQPILTEQQMSHGYNSDAVSQVGKSSACGISLKAEDVSLDQKVHLGSLPNTGLFWNQGCHAAELGLDTGHCKVFLESEDVGRTLDLSVLGSYEELYKKLTSMFMIERSELEGHVFYRDATGALKQTGDESFSEFVRTAKRLTIFKNPGNSVGRKWLTGLPTAERGLDSSNQAGPLSIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFR9</accession>
    <name>A0A068UFR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024668001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFR9"/>
    <dbReference type="FunCoup" id="A0A068UFR9">
        <property type="interactions" value="3062"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFR9"/>
    <dbReference type="Gramene" id="CDP07410">
        <property type="protein sequence ID" value="CDP07410"/>
        <property type="gene ID" value="GSCOC_T00024668001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFR9"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFR9"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="279" mass="30933" checksum="C8E009712B6BFACF" modified="2014-10-01" version="1">MLYIIGLGLGDEKDITLRGLEAVQKSQKVFIEAYTSLLSFGISSDGLSTLEKLYGKSITVADREMVEEKADDILLEATSSDVAFLVVGDPFGATTHTDLVVRAKKLGVDVKVVHNASVMNAIGVCGLQLYRYGETVSLPFFTDTWRPDSFYEKIQRNRKLGLHTLCLLDIRVKEPSLESLCRGKKQYEPPRFMAVSVAIEQLLEVEQMRGENAYTEDTTCVGFARLGSEDQLVVAGSMKQLLEVDFGLPLHCLVIVGDTHPVEEEMLDFYKLAKNQGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG33</accession>
    <name>A0A068UG33_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Outer envelope pore protein 24, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00024824001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomers form large rather nonselective pores in plastidial outer membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Etioplast membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG33"/>
    <dbReference type="FunCoup" id="A0A068UG33">
        <property type="interactions" value="2090"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG33"/>
    <dbReference type="Gramene" id="CDP07535">
        <property type="protein sequence ID" value="CDP07535"/>
        <property type="gene ID" value="GSCOC_T00024824001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG33"/>
    <dbReference type="OMA" id="AESTWNF"/>
    <dbReference type="OrthoDB" id="1185978at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034426">
        <property type="term" value="C:etioplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022843">
        <property type="term" value="F:voltage-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034626">
        <property type="entry name" value="OEP24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35284">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 24A, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35284:SF1">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 24A, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="12" id="KW-0626">Porin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP07535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23531" checksum="67D094BF762042B3" modified="2014-10-01" version="1">MKASFKAKYETDKAAAAATVAVNAGDIKLRASMTDATIVSGPNLNGLALAVEKPGFFIVDYNVPKKDFRFQFMNTIRVSEKPLNLTYMHSRGDNRTSLDGTLVFDSANKVSANHVLGSGNCKLKYTYVHGGLTTFEPSYDFSKNSWDFAISRRVYGDDVFRAAYQTSSKNLGLEWSRNSKLNGSFKISASLNLADERKMPKLTAESTWDFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG67</accession>
    <name>A0A068UG67_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00024859001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG67"/>
    <dbReference type="Gramene" id="CDP07565">
        <property type="protein sequence ID" value="CDP07565"/>
        <property type="gene ID" value="GSCOC_T00024859001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG67"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="72" mass="8580" checksum="0946141E81148A91" modified="2014-10-01" version="1">MTSLHQSERKEHGRDESWLLPDIKQLISPHIWSNIDYFSGFVERLVKLDTRVKSKWSINDELKSWNRHSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGQ9</accession>
    <name>A0A068UGQ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00025070001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGQ9"/>
    <dbReference type="STRING" id="49390.A0A068UGQ9"/>
    <dbReference type="Gramene" id="CDP07720">
        <property type="protein sequence ID" value="CDP07720"/>
        <property type="gene ID" value="GSCOC_T00025070001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGQ9"/>
    <dbReference type="OMA" id="WYWLENR"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGQ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08378">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04019">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08379">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000090">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000119">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000128">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047257">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047258">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047255">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047259">
        <property type="entry name" value="QUIRKY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425">
        <property type="entry name" value="PHOSPHORIBOSYLANTHRANILATE TRANSFERASE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425:SF49">
        <property type="entry name" value="PROTEIN QUIRKY-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="737"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="201"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="366"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="794" mass="90023" checksum="403FF27F18948546" modified="2014-10-01" version="1">MPPKNNQKGSQNQTRNANQNSIPSEDFDIRETSPALGGGRGSGNDKVGTAFDLVEQMHYLFVRVVKAKELPTKDGNGTPDSFVEVKLGNLRSETKHLKNVSNPEWNQVFAFLSDRIQAPVVEVLVRDKNRNGDDLIGMVVLDVMDVPKRVPPDSPLAPQWYTLENRKGDKVRGEMMLAVWIGTQADEAFPEAWHLDATTAVSGDGIANIRSKVYLSPRLWYLRVNVIEAQELQLSDKNRQQPDIFVKVALGNMFLRTKISQSKSTCPLWNEDLMFVAAEPFEEQLALSVEEKVAPNKDVVLGNCLIPLRGVERRIDLRTPINRWYGLEKHVVSENGHRNLVKLNSKVHLRISLDGGYHVLDELTNYSSDLRASAKQLWKPAIGLLELGILSAQGLSSTKTKDGHGTTDAYCVAKYGQKWIRTRTILNSLNPKWNEQYTWEVFDPCTVITIGVFDNCHLQGADRGGGVKDSRIGKVRIRLSTLETNRVYTHSYPLIVLLPSGVKKMGEIQLAVRFSCSSLLNTLQMYSQPLLPILHYLHPLTRYQTDNLRHQATQIVSLRMSRAEPPLRREVVEYMLDVGSNMWSVRRCKANHYRIASAMSGIVAFLQWFNGICTWKNPFATILVHILLLIFVAFPQIILSCSFLFLFLVGICNYRGRPRYPPHMDIKLSQADRAHPDELDEEFDTFPTSRHSDVLRMRYDRIRSIGSRVQTVVGDLATQGERFYSLLSWRDPRATGLFLIFCLVASLVVYIIPSKALVVAVGFYLMRHPAFREELPALPLNFFRRLPTRTDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIE4</accession>
    <name>A0A068UIE4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00027097001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIE4"/>
    <dbReference type="FunCoup" id="A0A068UIE4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIE4"/>
    <dbReference type="Gramene" id="CDP08305">
        <property type="protein sequence ID" value="CDP08305"/>
        <property type="gene ID" value="GSCOC_T00027097001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIE4"/>
    <dbReference type="OMA" id="DDWMEED"/>
    <dbReference type="OrthoDB" id="693960at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIE4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF112">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 50-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20920" checksum="625DDD2056D2B570" modified="2014-10-01" version="1">MDGNYDPNRFTNMSGYNYNSSSAFGSSYSSGMISTGYGDTNQSNFQVSEYFELDDWMEEDQTFMPSGYSTAQSPQQELTEVLGHPGGSSSQQSNRDIGGNERKENREKVAFKTKSEVEILDDGFKWRKYGKKMVKNSPNPRNYYRCSIEGCPVKKRVERDKEDPRYVITTYEGIHNHQGPSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ75</accession>
    <name>A0A068UJ75_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024997001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ75"/>
    <dbReference type="FunCoup" id="A0A068UJ75">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJ75"/>
    <dbReference type="Gramene" id="CDP07668">
        <property type="protein sequence ID" value="CDP07668"/>
        <property type="gene ID" value="GSCOC_T00024997001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ75"/>
    <dbReference type="OMA" id="DPIVICA"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ75"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF202">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="291" mass="31892" checksum="F4EE51998247B550" modified="2014-10-01" version="1">MDSFTPSPHPNPTNLYPNPLSFFEPFSPMDPINPSEDTFLLESPYLHRLIHHLMTNTNNIPNQTSPTPPQFNSPASKHAIESLSHVIVDSTFLDLDPSLVCPVCKDQFLVSSEAKVLPCNHTYHADCIVPWLEMNNSCPVCRYRLPSESDERKKNEAVRGRETYIGAARLDELLDDEQDLFGFTSILRNVVRRQQYNNGNDDEEYSSSWNRRVQWDNDVLLSPTQIGEAEGVGVGGGIGAHVERANSAETVSSWPRWPTEGGASGSGSGDGEIGVGVAGGGAVIKGDAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJY9</accession>
    <name>A0A068UJY9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00027495001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJY9"/>
    <dbReference type="STRING" id="49390.A0A068UJY9"/>
    <dbReference type="Gramene" id="CDP08544">
        <property type="protein sequence ID" value="CDP08544"/>
        <property type="gene ID" value="GSCOC_T00027495001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJY9"/>
    <dbReference type="OMA" id="YYQIARR"/>
    <dbReference type="PhylomeDB" id="A0A068UJY9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP08544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="188" mass="21441" checksum="AE4C089746DFBDFF" modified="2014-10-01" version="1">MGLLLTKLSQLFAQKQARVLMVGLDAAGKTTVLYKLKLGEVVTTIPTIGFNVETVEYKSISFTVWDVGGQDRIRPLWKYYYQSTQALIFVIDSSDRDRVAEARDELHRMLNEDELRNAVLLVLANKQDLANAMNVAELTDKLGLHSISQRQWYIQSTCATTGEGLYEGMEWLSRNIADKVEYYQIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJZ0</accession>
    <name>A0A068UJZ0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027857001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJZ0"/>
    <dbReference type="Gramene" id="CDP08766">
        <property type="protein sequence ID" value="CDP08766"/>
        <property type="gene ID" value="GSCOC_T00027857001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJZ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="49" mass="5366" checksum="CE62D03B7FF6A101" modified="2014-10-01" version="1">MEVFFFLFFIVCVCVCVCVCVCLCVCVCVCVCVCGVVTGKRVREGGCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKL8</accession>
    <name>A0A068UKL8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00027842001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP08754">
        <property type="protein sequence ID" value="CDP08754"/>
        <property type="gene ID" value="GSCOC_T00027842001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKL8"/>
    <dbReference type="OMA" id="IPNIAHD"/>
    <dbReference type="OrthoDB" id="1921377at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKL8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF111">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="235" mass="26296" checksum="347EBB8F2A3ADC7E" modified="2014-10-01" version="1">MNLRSSPLLFMEGQDQETPPLPLPVPSPPTNPSFLFAQPHLPSPNSSLIFPNISHSQPLVLQDNLHDLVGLFSAPPPTPSGIPNIAHDNTNDQIMMPSLETAPLTISDNAVAPSPEEVAIKDKIRRAASSSSKNRKNTVPKVVFQTRSPDDILDDGYRWRKYGQKSVKNSKYPRSYYRCSHHTCNVKKQVQRLSKDTSIVVTTYEGIHNHPCEKLMETLSPLLEQIQFLTRPVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULT5</accession>
    <name>A0A068ULT5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00028910001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068ULT5">
        <property type="interactions" value="1866"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULT5"/>
    <dbReference type="Gramene" id="CDP09515">
        <property type="protein sequence ID" value="CDP09515"/>
        <property type="gene ID" value="GSCOC_T00028910001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULT5"/>
    <dbReference type="OMA" id="CEAQMES"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULT5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02087">
        <property type="entry name" value="HAUSAUGMINL1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP09515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="42473" checksum="C9D78C844ED1A86B" modified="2014-10-01" version="1">MIFQKNQRLFQQFSQKQRLCSVKSCLKQSLKPAFLTSNPLNRLLHQVAPSPSLPLSLCLCKCVQISFGLRGKRREMSEIVGGGDPSPSVTSEASKNSSSGFDANRIAEVKSWLESQFSAVGKEVPEFEYTPRSIAHLHNIATISQAKTQAASIVANDFRQKATEYRAQAARIREILEHVGLAQESLPSDVVSSAQVLANVANLLNIRDTELSSFLVAMADLSLRKTAVEEKRSKVQQESKVLLDFTRKAISRLTYLKRILAQLEDDIAPCEAEMESRRTNLAIMDSKERQYEKQFSNCKAMLNRVGYSPEISHGVLAEMAEHRKELERKTKPILDTLRSYQDLPPDKALAVLAIEDKKRQYAAAEKYLEEVLQSALASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULW3</accession>
    <name>A0A068ULW3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00028422001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULW3"/>
    <dbReference type="FunCoup" id="A0A068ULW3">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULW3"/>
    <dbReference type="Gramene" id="CDP09194">
        <property type="protein sequence ID" value="CDP09194"/>
        <property type="gene ID" value="GSCOC_T00028422001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULW3"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULW3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP09194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="310" mass="33216" checksum="D19265388956D3E9" modified="2014-10-01" version="1">MAGSGVVTVYGNGAITETAKKSPFSVKVGLAQMLRGGVIMDVVTPEQARIAEEAGACAVMALERVPADIRAQGGVARMSDPQLIKEIKQAVTIPVMAKARIGHFVEAQILEAIGIDYVDESEVLTPADDENHINKHNFRIPFVCGCRNLGEALRRIREGAAMIRTKGEAGTGNIIEAVRHVRSVMGDIRVLRNMDDDEVFSFAKKIQSPYDLVMQTKQLGRLPVVHFAAGGVATPADAALMMQLGCDGVFVGSGVFKSGDPARRARAIVQAVTHYSDPEVLADVSCGLGEAMVGINLNDDKVERYANRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULX4</accession>
    <name>A0A068ULX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00028967001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULX4"/>
    <dbReference type="FunCoup" id="A0A068ULX4">
        <property type="interactions" value="2056"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULX4"/>
    <dbReference type="Gramene" id="CDP09550">
        <property type="protein sequence ID" value="CDP09550"/>
        <property type="gene ID" value="GSCOC_T00028967001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULX4"/>
    <dbReference type="OMA" id="KRCAELH"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000225">
        <property type="entry name" value="Protein SMG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF25">
        <property type="entry name" value="OS08G0305300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="69"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="209"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="106066" checksum="0FCB896622EFE70A" modified="2014-10-01" version="1">MTIPMDNNPDNSSRERVQKLFNKNVELENRRRKAAQARIPSDPNAWQQMRENYEAIVLEDHAFSEQHEIEYALWQLHYRRIEELRAHFNAAAASVSAGSNTSQNGKGPTRGGPDRLTKIRTQFKTFLSEATGFYHDLMLKIRAKYGLPLGYFSDDSENQIPLCKDGNKSAEVKKGLISCHRCLIYLGDLARYKGLYGEGDSKSRDFAAASSYYMQAASLWPSSGNPHHQLAILASYSGDELVAIYRYFRSLAVDSPFTTARDNLIIAFEKNRQSFAQLLGDARASSVKTTSVRGNGKGRGRGESRVASKDNKVEASSVKEKTSTTLETFRAFGIRFVRLNGILFTRTSLETFGDVFAVVRGDLLELLSSGTDEEYNFGSDATDCRLAIGRMVAILIFTIHNVNRETENQSYAEILQRSVLLQNAFTATFEFMGHILERCSQLNDPSSSYLLPGIMVFVEWLACHQDIAVGSELEEKQASARLFFWNNCISFFNRLISSGFMFVDEDEEETCFSNMSRYDESETANRLALSEDFELRGFVPLLPAQLILDFSRKHSFRSDSNKEKKARVQRIIAAGKALANVVRIGEEGIYFDTKSKRFVVGVEPQVSDDFSLTTTLEAPKLSGVVEDNLVSGQMTPRALEQKPQLYMEGEEEDDEVIVFKPSMTEKHLDGIALNPTSSEVFGSTMNAASIGGDVGSFSTGREGYIAQNAFSASLRPPTSLVNSSYLQPVQPSTTWMAEQGTLVNGLGNLNLFENGFIKKPESQKHFGALPAQTFPVSLPDSSFGTGSNFPNQLPETVVPSKLDSIMSLGADNISMKPSSVSPAGLKKNPVGRPLRHLGPPPGFGSVPSKTVDESLSAMSFKNENATIPQMDDYSWLDGYQLPLVNRSVAGLNSSNHPGQGYPIGSKSSSSMGMPSFPFPGKQTTTLQQQQQLQKANQQSAVLQQQYQGQSLWEGRFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMC6</accession>
    <name>A0A068UMC6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00028746001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMC6"/>
    <dbReference type="FunCoup" id="A0A068UMC6">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMC6"/>
    <dbReference type="Gramene" id="CDP09399">
        <property type="protein sequence ID" value="CDP09399"/>
        <property type="gene ID" value="GSCOC_T00028746001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMC6"/>
    <dbReference type="OMA" id="KRPVSMN"/>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMC6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF179">
        <property type="entry name" value="OS10G0565000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="542" mass="60362" checksum="7D3FE98AC9174F18" modified="2014-10-01" version="1">MHQKKSEVQIGKESCGISSDFNPTPPLSNLPPSLHHKQHSSNPQQFYSSHYTTPNNFAASILTSSPSSPPPNSPSSPCSSLSDNPNNNHSLHIIINENEPIAPSIASSPTTKTTPHKRPHLGQSQFSTKSSNSLIKSPTLSNSLHKYPFSPAPVAPKNNFHYRRLLRHLHLRRLRVHIRLVLLLSLPFFYFLVSHPSHSFVLDFLSAFAFSAALLFSLNLALPRLPSIRLFLARSLPIKLPSSSQVVSGTNRPHLPVFWSIGSRPKTEKRANSGCWVQAYSNGDVYEGEFHKGKCSGSGVYYYYMSGRYEGDWVDGKYDGYGVETWARGSRYRGQYRQGLRHGFGVYRFYTGDVYAGEWSNGQSHGCGVHTCEDGSRYVGEFKWGVKHGLGHYHFRNGDTYAGEYFADKMHGFGVYSFANGHRYEGSWHEGRRQGLGMYTFRNGETQSGHWQNGILDVPSTQNASHPVSPVAVYHSKVLNAVQEARRAADKAYDVAKVDERVNRAVAAANKAANAARVAAVKAVQKQMHHRSNSDDIPIPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMK6</accession>
    <name>A0A068UMK6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028945001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMK6"/>
    <dbReference type="Gramene" id="CDP09537">
        <property type="protein sequence ID" value="CDP09537"/>
        <property type="gene ID" value="GSCOC_T00028945001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMK6"/>
    <dbReference type="OMA" id="YNNREAS"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF12">
        <property type="entry name" value="OS06G0602900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="346" mass="37966" checksum="544A985F0D1ACD93" modified="2014-10-01" version="1">MEVTNRYVVTRHHIDGTPQESDFELKTEALSLSIEPGKKELIVKILYLSIDPYQLNRMKQKSSSQETTSSARAVKPFEAIDAHGVGRVVASGNPAFKEDDLVAGLLTWGEYCTVKEGGLLNKVDNIGFPISHHVGVLAFSGLTAYAGFFEVCKPKKGEKVFVSAAAGSVGNLVGQYAKLFGCYVVGCAGSQKKVDLLKEKLGFDEAFNYKEETDLKSALKRYFPDGIDIYFDNVGAEMLEAAVENMNTFGRVAVCGAISEYTDKGKRAAPNMVDIIYKRITMQGFLSVDHMKVYKDFISDTVEHIRAGKLQVLEDISHGLESIPSAFVGLFRGDNMGKKMVQVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMU1</accession>
    <name>A0A068UMU1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ripening-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00030199001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kiwellin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMU1"/>
    <dbReference type="STRING" id="49390.A0A068UMU1"/>
    <dbReference type="Gramene" id="CDP09746">
        <property type="protein sequence ID" value="CDP09746"/>
        <property type="gene ID" value="GSCOC_T00030199001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMU1"/>
    <dbReference type="OMA" id="YLCATHL"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMU1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22270">
        <property type="entry name" value="DPBB_kiwellin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039271">
        <property type="entry name" value="Kiwellin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33191:SF58">
        <property type="entry name" value="RIPENING-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33191">
        <property type="entry name" value="RIPENING-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24300">
        <property type="entry name" value="KWL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657818" description="Ripening-related protein 1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP09746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20882" checksum="328DBE0A4D4D28AA" modified="2014-10-01" version="1">MRKQVQFSSICLLVLLSIIALACTILMVEAKPCTPSGKIRGKQAPRDQCDPHTDDCCQAGRVYKTYECSPPVSKRTKAILTINDFQKGGDGGGTSACDNKFHSNNTPVVALSTGWFNGLKRCHKYITIFGNGRSARAMVVDECDSTKGCDSDHGFQPPCQNSIVDASEAVWKALKVPKKDWGSMEVFWADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN87</accession>
    <name>A0A068UN87_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030415001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN87"/>
    <dbReference type="STRING" id="49390.A0A068UN87"/>
    <dbReference type="Gramene" id="CDP09921">
        <property type="protein sequence ID" value="CDP09921"/>
        <property type="gene ID" value="GSCOC_T00030415001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN87"/>
    <dbReference type="PhylomeDB" id="A0A068UN87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="8875" checksum="DED592EF10B1C7A7" modified="2014-10-01" version="1">MNFKARTIAGNEIWSPKCISALLLILDNLLQSRPRISRESTEETTAGLIPDSSEKHVASPVLEDVAEKKSTPLLQDKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNP5</accession>
    <name>A0A068UNP5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00030654001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Perrotta G."/>
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                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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        <location>
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            <end position="86"/>
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        </source>
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    <sequence length="286" mass="32671" checksum="618E1914459F1B1F" modified="2014-10-01" version="1">MDGYRKTTLKPWKKGPARGKGGPQNAMCEYRGVRQRTWGKWVAEIREPKKRTRLWLGSFATAEEAAMAYDEAARRLYGPDAYVNLPHLRSNFNPLNKSQKFKWFPSNSLVSMFPSTGLLNLNAQPSVHVIHQRLQELKETGLLCQTSSASTSSSNPKSDVEYVDDHPHVESLEGKNNDEAEHPWENKSLNQEEKPQIDLNEFLQQLGILKKEDQPGVSEVPSNFIDKDFSPKDDDVFTNLPENIFNWETPSELPGIEDNQLVENSRFHVDNDNDDDPSFPPSIWNF</sequence>
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            <taxon>Coffea</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
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                <person name="Perrotta G."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Albert V.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NuA4"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP10460.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="144" mass="15790" checksum="F8DE9988446100FE" modified="2014-10-01" version="1">MESEGQRTSSAPSAVLASLLCKRAKLHEELRNIEKQVYDMETSYLQDPSQCGNVLKGFEGFLSSSKNTTLLKRSRKFQPEDRLFSLSSTTSPAAEEQAAGRDGGALLANGQGKPKKGRGGPRDAKRSRQSSEPDFDYEDDADLM</sequence>
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    <accession>A0A068UPN9</accession>
    <name>A0A068UPN9_COFCA</name>
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            <fullName evidence="7">60S ribosomal protein L17</fullName>
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        <name evidence="5" type="ORF">GSCOC_T00029021001</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPN9"/>
    <dbReference type="STRING" id="49390.A0A068UPN9"/>
    <dbReference type="Gramene" id="CDP09588">
        <property type="protein sequence ID" value="CDP09588"/>
        <property type="gene ID" value="GSCOC_T00029021001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPN9"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11461" checksum="7F67F8EEB2A93953" modified="2014-10-01" version="1">MHQKKKKERHKTALFDFGGRFICSKTLKIFILLVKGLDVDSLFISHIQVNQAHKQRRRTYRAHGRINPYMSSPCHIELILSEKEESVKKEVIHTCRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQ66</accession>
    <name>A0A068UQ66_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00030161001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQ66"/>
    <dbReference type="STRING" id="49390.A0A068UQ66"/>
    <dbReference type="Gramene" id="CDP09718">
        <property type="protein sequence ID" value="CDP09718"/>
        <property type="gene ID" value="GSCOC_T00030161001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQ66"/>
    <dbReference type="OMA" id="KSIPHRY"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQ66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF591">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="249"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP09718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="399" mass="45084" checksum="C3B9BAD4E732443E" modified="2014-10-01" version="1">MSAESIEFEHMDLIDFAVKQGNGVNGLSKLGLKSIPHRYILPPEERLNQNQVVLEDSIPIIDVSNWGDPEAAALICEAAAKWGFFQIINHGVPLEVLEDVLEAGHKFFELPNEERRKYLKENSPTPTVQLKTGFSPLAEKVFEWKDYLVHHYVPHNVSSDLWPSVSKCMMYLDWPSLNGITFLSIRNLISVMTVAFTPGNDLTSEVYIRDQVLEYLKWAKPVIKKLVEVLLQGLNVKEFDESQESQLIDRTTISLIHYPMCPSPELACGARRHSDISSITILLQDDVGGLYVKGTTADQWIHVSPVKGALAVNIGDILQIVSNDRYKSIEHQVIVNGRRNRVSVPIFVSPAADTVVGPFPQSLENGKKPIYKHVIYSDYLNYFLSKRDDRNQTIEFAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQF0</accession>
    <name>A0A068UQF0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00031563001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQF0"/>
    <dbReference type="STRING" id="49390.A0A068UQF0"/>
    <dbReference type="Gramene" id="CDP10750">
        <property type="protein sequence ID" value="CDP10750"/>
        <property type="gene ID" value="GSCOC_T00031563001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQF0"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQF0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP10750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="102" mass="11778" checksum="2B1B6D1800B317FE" modified="2014-10-01" version="1">MRSYDNILRPHAILYYSQRATKGGLLIAEATIVSETGRVWTKEQVEAWKPIVDAVHAKCGIFFCQIWHAGRISNYSEFLSCYNFCNFLYSICRVFLGPMPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQP5</accession>
    <name>A0A068UQP5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00030441001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQP5"/>
    <dbReference type="FunCoup" id="A0A068UQP5">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQP5"/>
    <dbReference type="Gramene" id="CDP09938">
        <property type="protein sequence ID" value="CDP09938"/>
        <property type="gene ID" value="GSCOC_T00030441001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQP5"/>
    <dbReference type="OMA" id="THLDSMR"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQP5"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP09938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="356" mass="38522" checksum="06DE42978AF67270" modified="2014-10-01" version="1">MKKIESSSTLGPGGLDISRAFFKPILNSAPPSPTKRHTKISVIGAGNVGMAIAQTILTQDLVDELALVDAKPEKLRGEMLDLQHAAAFLPRTKIHASVDYSITAGSDLCIVTAGARQIPGESRLNLIQRNLALFKLIIPPLARYSPDCILLIVSNPVDVLTYVAWKLSGFPPNRVIGSGTNLDSSRFRFLLADHLDVNAQDVQASLAYMVGEHGDSSVALWSSISVGGVPVLSFLERQKIAYEKETLENIRKEVVESAYEVINLKGYTSWAIGYSAANLARSLLRDQRKIHPVSVLATGLYGIDGGDVFLSLPAQLGRSGVMGVANVELTDWEAQQLRNAAATILEVQSQLEIEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URY8</accession>
    <name>A0A068URY8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00031099001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739129">
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
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    </evidence>
    <sequence length="216" mass="24340" checksum="BFDA93F95DD64204" modified="2014-10-01" version="1">MMRLLLSKTASARNSLHFSQFNSQRGMHGRNKKAMEFIAKGWNALKEVDRVIDYCDLNDHRLIPMLRTAKENFELALEADNSNTHARYWLSKLHLKYHAPGACKAIGAALLVEAADMGDKDAQYELGCRLRVENDYVQSDQQAFYYLEKAVDQLHPGALYLLGAVYLTGDCVKKDVASAIWCFHRASERGHAGAAIAYGSLLLRGKMPLFFFSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US54</accession>
    <name>A0A068US54_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cysteine-rich receptor-like protein kinase 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00033582001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739138">
        <property type="protein sequence ID" value="CDP11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="HTCLETS"/>
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        <property type="component" value="Chromosome VII"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:defense response to bacterium"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 23"/>
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        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNK2"/>
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        <property type="entry name" value="GNK2_sf"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1108">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="18">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="18">
        <location>
            <begin position="139"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="370"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71729" checksum="9AB735D8E679DEE2" modified="2014-10-01" version="1">MLCLLSFHTIEYCCSTSNDTDPWNYLDSYCGNITYNPNSPSGSIYRANLNFLLYNLSSHASRTDNNGFYNFSTGDDPSNKVYGLFLCRGDVHTDVCKECVADAHTRLLHECPNQTAAIVWYDECLVRFSDQTIFSKADLGENVTRRNPFDVPGPDWDKFKMVLINLLHNAADEAANHTMGKKFAVQEGNYSTDQKRLYTLTQCTPDLSPYDCKSCLREAIMDVPACCSKKQGGRVLYPSCNLRYEVSSFYDNVSSASPNSPGGPPPNSTEGNQNLVEYVTVRFPHQHILLITCIIICNLWKILSGKGRSPPRAAFSIAVPLIGVAVVLFVMALVFLKRRLRKSYVAMAPETSAESLQYSLTEIQIATNNFSVDNKIGEGGFGRVYKGVLGNGQEVAVKRLSRSSVQGAEEFKNEIVVVAKLQHRNLVRLLGFCLEGEEKILIYEFVANKSLDYFLFGGFNLDILIQICGVDQYEGNTNRIAGTVGYMAPEYTRWGQFSLKSDVFSFGVVILEIVTGKKSSDFHQSRDSEDLLSYAWNHWRRGQTLALWDSSVGDSYARNEVIQCIQVGLLCVEEDASKRPKMASVVSMLNPGSVSLPTPHRPAVFRSNGSESRVDELKVDQSNTQRISAPSSVNDASITEPYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV55</accession>
    <name>A0A068UV55_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00035969001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739149">
        <property type="protein sequence ID" value="CDP12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV55"/>
    <dbReference type="STRING" id="49390.A0A068UV55"/>
    <dbReference type="Gramene" id="CDP12430">
        <property type="protein sequence ID" value="CDP12430"/>
        <property type="gene ID" value="GSCOC_T00035969001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV55"/>
    <dbReference type="OMA" id="EMAYLHR"/>
    <dbReference type="PhylomeDB" id="A0A068UV55"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF602">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657996" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="797"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120600" checksum="49DCD7E79C455FD9" modified="2014-10-01" version="1">MEKLHNLSPFGFVLLCFLSASLAMLPTNITTDQSSLLALRSHISFDPHQILANNWSVRSSVCEWIGVTCGFRHLRVTGLSISNMNLSGTLPPQLGNLSFLVSLDMRNNNFHGEMPHEIARLRRLKVLNLGINNLKGDRIPSSISNLSKLETIYLSFNPLQGNIPTGIFNISSLQIIHLMDNGLSGVLPSDMCYRLPGLSILDLSMNKLNGQLPSSALAQCSELQVLSLSINKFGGSIPKEIGGLKKLEELYLGINYLEVCLLDNCKQLNTKFHIFHNFVIMLIYSLMMMLKFSRYANLFTKLTEYRDLYILMYMLKIILAGVIPREIGNCYFLQHVNMEFNSLTGSIPIEIFNLSKLIIMSLTQNQLSSNLPSTFGYRLPNLEELYLGINSFSGVLPTSISNSSKLRRVDFGSNKFTGPIPTSLGDLSLLELLNLSNNNLTRDSSSQELSFITSLTKCQYLSILVFSDNPLNGIIPNSVSNLSTSLQMLSASDCKIKGSIPNGIGNFSSLIQLDLSNNELNGSLPARIKDLHMLQGMDLNLGQNQIMGSIPKCMGNFTSLRNLNLSHNRLNSTPPVEIWNLKDLLELDLSSNLLSGSLPQAITNMKMANWVDLSINQLSGGIPDSIGEMQNLKNLSLAHNRLEGSIPESIGKMLSLESLDLSHNFLSGSVPMSMENLRYLRHFNVSFNNLIGEVPSKGPFINFTAASFTSNQALCGAQRFHVPPCPNNSAHKLRTKKLHRTIFILLGVIIAAGALSFGFVYLRYRKKDTVSGLANLSLVAMPERISYFELLKATNGYNESNLLGTGSFGSVYRGTLDNGRVVAAKVFNLHVEGAFKSFDVECEVLRNLRHRNLTGVITSCSNPEFKALVLEFMPNGSLEKWLYSHNYFLDLMQRLDILIDVACALQYLHCEYSTPVIHCDLKPSNVLLDQDMVAHLSDFGLTKLLGEENSITYTETLATLGYLAPEYGLEGLVSRKCDTYSFGIMMMEVFTRTKPNSEMFGENLSLKSWVTDSIPDELAHVIDANLLKESDEYFVEKLSCIASIMKVALDCTMESPRERSNIQDVLVALKKIKLQYISALHSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVG4</accession>
    <name>A0A068UVG4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035645001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVG4"/>
    <dbReference type="FunCoup" id="A0A068UVG4">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVG4"/>
    <dbReference type="Gramene" id="CDP12224">
        <property type="protein sequence ID" value="CDP12224"/>
        <property type="gene ID" value="GSCOC_T00035645001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVG4"/>
    <dbReference type="OMA" id="LDWHGPH"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVG4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000140">
        <property type="entry name" value="Esterase/lipase/thioesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF84">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="378" mass="41199" checksum="55601390F46CE68B" modified="2014-10-01" version="1">MSNQPTPHPSLEVIGGARDSFLPAFTSLHTPYHPYPFIAWNRHVETIFAAFFRSLPDIKFRRECLRTKDNGTVALDWVSGDRTRLSAVAPVLILLPGLTGGSQDSYVRHMLVRARSKGWRVVVFNSRGCGNSPVTTPQFYSASFLGDMSEVVALVNNRYPKANVYAVGWSLGANILVRYLGQESRSCVLSGAVSLCNPFNLVIADEDFRKGFNIVYDKSLANGLCKIFTEHAPLFEEMDGEYNISAAANAKSVREFDEALTRVSFGFKSVDDYYSNSSSSDSIKNVCVPLLSKSKAAANDPIAPSRGIPREDIKANSNCLLIVTPKGGHLGWVAGGEAPRGAPWTDPPVMEFLEHLERAAACSSVGSGGLQHVEASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVJ4</accession>
    <name>A0A068UVJ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035703001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVJ4"/>
    <dbReference type="Gramene" id="CDP12264">
        <property type="protein sequence ID" value="CDP12264"/>
        <property type="gene ID" value="GSCOC_T00035703001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVJ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658006" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7581" checksum="E107311B707B632C" modified="2014-10-01" version="1">MSSRPYLSLVTLLYLLTRTRIGQGCTSFPPLSVKIAYSKMMDMGWMLPSISSSALTGLALRENILRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWK4</accession>
    <name>A0A068UWK4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00036386001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWK4"/>
    <dbReference type="STRING" id="49390.A0A068UWK4"/>
    <dbReference type="Gramene" id="CDP12667">
        <property type="protein sequence ID" value="CDP12667"/>
        <property type="gene ID" value="GSCOC_T00036386001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWK4"/>
    <dbReference type="OMA" id="IAFRTFE"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000097">
        <property type="entry name" value="Calcium-transporting ATPase 9 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="648"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="864" mass="93895" checksum="5987920148358509" modified="2014-10-01" version="1">MHIPECLICYAVSDYRQSLQFQSLNEEKQNIHLEVVRGGRRIEVSIFDIVVGDIVPLKIGDQVPADGILVSGHSLAIDESSMTGESKIVQKDSKAPFLMSGCKVADGYGNMLVTNVGINTEWGLLMASISEDNGEETPLQVRLNGVATFIGIVGLAVAAIVLIVLFIRFFTGHTYNADGSRQFKAGRTKASTAIDGAIKIFTVAVTIVVVAVPEGLPLAVTLTLAYSMRKMMRDKALVRRLSACETMGSATTICSDKTGTLTLNQMTVVEAYVGGKKVDPPDDKSLLPPKLTSLLTEGIAQNSTGSVFLPEGGGDAEVSGSPTEKAILQWGLNLGMNFDVIRSSSSIIHAFPFNSEKKRGGVAVKLPDSDIHVHWKGAAEIVLASCTAYMDENDGIQPIEEKVLDFKTAIEDMAARSLRCVAIAYRHHEGKDVPTNEEELSNWQLPEGQLVLLAIVGIKDPCRPGVRDAVQLCRNAGVKVRMVTGDNLNTARAIALECGILTSDADADATEPNLIIEGKAFRALSEERRREVAEKISVMGRSSPNDKLLLVQALRKKHVVAVTGDGTNDAPALHEADIGLAMGIQGTEVAKESSDIIILDDDFASVVKVVRWGRSVYANIQKFIQFQLTVNVAALIINVVAAVSAGDVPLNAVQLLWVNLIMDTLGALALATEPPTDHLMNRPPVRRREPLVTNIMWRNLLIQALYQVTVLLILNFRGKSILHLEHDNADHANKVKNTMIFNAFVLCQVFNEFNARKPDEINVFKGVTKNHLFMGIIGLTVVLQVVMIFFLGKFTSTVRLSWKLWLVSIAIGLISWPLAAIGKWIPVPETPLGELLTGKIRQQRNGGGGNLNCCSILKKKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX82</accession>
    <name>A0A068UX82_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037788001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX82"/>
    <dbReference type="FunCoup" id="A0A068UX82">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UX82"/>
    <dbReference type="Gramene" id="CDP13036">
        <property type="protein sequence ID" value="CDP13036"/>
        <property type="gene ID" value="GSCOC_T00037788001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX82"/>
    <dbReference type="OMA" id="SMFKASN"/>
    <dbReference type="OrthoDB" id="691764at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX82"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34197">
        <property type="entry name" value="OS04G0591300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34197:SF2">
        <property type="entry name" value="OS04G0591300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="250" mass="27448" checksum="788F8804FC31FF56" modified="2014-10-01" version="1">MAAYMDEEEVFKCPQHPSKRRRNGICPTCLRDRLITLCPDCANVRPCACCPATTTSSSSSSSSSTFSFFSSASSSRRGGRVSDLLDKESAFRRSRSVGVPFLFTRFAREKQAENSPARKKSRTAALLAKFGLNSSKSKKREEFEENKENENSKVAAAAAPAEQKFANSCNSDGNNECRQSCSNASIEEFANMMMRSRSVSVGMMNHSGERRHSSSSASGKGKGWSFPSPMKVFRPKTPKVANDRSPMCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXN6</accession>
    <name>A0A068UXN6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Seven-in-absentia protein TRAF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00038017001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXN6"/>
    <dbReference type="STRING" id="49390.A0A068UXN6"/>
    <dbReference type="Gramene" id="CDP13166">
        <property type="protein sequence ID" value="CDP13166"/>
        <property type="gene ID" value="GSCOC_T00038017001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXN6"/>
    <dbReference type="OMA" id="IACLCKF"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052088">
        <property type="entry name" value="E3_ubiquitin-ligase_SINA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315">
        <property type="entry name" value="E3 UBIQUITIN PROTEIN LIGASE SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315:SF118">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Seven-in-absentia protein TRAF-like" evidence="5">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="163" mass="19166" checksum="C73D7E3B19B5AB99" modified="2014-10-01" version="1">MRVIACLCKFNSCNNTKYNQRKRKNHMFLRPTKVHSRGLPVDFIKCKPCLLFLSAQVFNYFGHQFCLHFEVFHLGTAPVYMAFLRFMGTDEDAEKFCYSLEVGRKGRKLTWQGVPRSIRDSYLIVRDNLDGLIIYRSMALYFSGGNMKELKLKVSGRIWRKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V089</accession>
    <name>A0A068V089_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cytokinin dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040425001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-dimethylallyladenine + A + H2O = 3-methyl-2-butenal + adenine + AH2</text>
            <dbReference type="Rhea" id="RHEA:13625"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15825"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="EC" id="1.5.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.99.12" evidence="3"/>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V089"/>
    <dbReference type="STRING" id="49390.A0A068V089"/>
    <dbReference type="Gramene" id="CDP14175">
        <property type="protein sequence ID" value="CDP14175"/>
        <property type="gene ID" value="GSCOC_T00040425001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V089"/>
    <dbReference type="OMA" id="TIKHIWN"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V089"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019139">
        <property type="term" value="F:cytokinin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000021">
        <property type="entry name" value="Cytokinin dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.462.10:FF:000001">
        <property type="entry name" value="Cytokinin dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015345">
        <property type="entry name" value="Cytokinin_DH_FAD/cytokin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF120">
        <property type="entry name" value="CYTOKININ DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09265">
        <property type="entry name" value="Cytokin-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="437" mass="49043" checksum="AEFD7EFA47F59238" modified="2014-10-01" version="1">MGGSSDITVAARGRGHSLAGQAQARGGVIMSMESLRHPEMRFYPGKMPYVDVSGGELWINILHESLKHGLTPKSWTDYLHLTVGGTLSNAGVSGQAFRHGPQINNVHQLEVVTGTGEVVRCSDDENSDLFHGVLGGLGQFGIITRARIALGPAPTMVKWIRVLYSDFSIFTEDQEFLISSQNSFDYIEGFVIINRTGLVNDWQSSFSPKDPVRSSQLQSEGKVLFCLEVAKYLYPENNYDVNQNIETILSELNYIPSTLFQSEVPYVQFLDRVHISEMKLRKKGLWEIPHPWLNLLVPKSKIHDFAAGVFGNIIRDTSNGPILIYPVNKSQWRNGTSMVSPEEDIFYLVAFLSSAIPYSTGKDGLEHILSENKRILNFCASTQLGVKQYLPQYSTQDEWKAHFGKQWEVFSRRKSTYDPLAMLAPGQRIFKKAVAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0Q5</accession>
    <name>A0A068V0Q5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00040366001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0Q5"/>
    <dbReference type="Gramene" id="CDP14132">
        <property type="protein sequence ID" value="CDP14132"/>
        <property type="gene ID" value="GSCOC_T00040366001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0Q5"/>
    <dbReference type="OMA" id="HITREND"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0Q5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050404">
        <property type="term" value="F:zeatin O-beta-D-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016138">
        <property type="term" value="P:glycoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000238">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058980">
        <property type="entry name" value="Glyco_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044:SF23">
        <property type="entry name" value="ANTHOCYANIDIN 3-O-GLUCOSYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26168">
        <property type="entry name" value="Glyco_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP14132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="451" mass="50362" checksum="D3862619C4FEA4D1" modified="2014-10-01" version="1">MVPLPAQGHLNQLLHLSRLISSYNIPVHFVGSATHNRQAKDRVHGWDPLAISDIRFHEFPLPSFPTPPPDPKAPTKLPTQLVPAFFATLHLREPACELVTKLSSTARRVVVIHDSLMCYVVQDMPSIPNAESYCFQSVSAFALYSYVWEAMGKPVLADGEPVNDLLSTPESVFPEELAEFFKVQQEARKCNWGNLFNSSRLIDGEYLNLLAEIKFDETENNWAIGPFNPPVITEDQKSKKSHKCLEWLDKQAPKSVIFVSFGSTTSLSDEEVEQIAIGLERSGQKFMWVLRDADTGDVSIGEGRKAQLPEGYEERVDGRGFILREWAPQLEVLGHPSTGGFMSHCGWNSCVESISMGVPMAAWPMHSDQPRNAILVTKILKTGLMVGDLAHQDESFKAEVVEDAVKRLMNSTEGQEMRKRAEELSDALKQSVIKGSDNSTEMDTFIAHITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1I3</accession>
    <name>A0A068V1I3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00042019001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="HG739174">
        <property type="protein sequence ID" value="CDP14640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1I3"/>
    <dbReference type="FunCoup" id="A0A068V1I3">
        <property type="interactions" value="2646"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1I3"/>
    <dbReference type="Gramene" id="CDP14640">
        <property type="protein sequence ID" value="CDP14640"/>
        <property type="gene ID" value="GSCOC_T00042019001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1I3"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1I3"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP14640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="309" mass="34033" checksum="A3A4C9BFE83E54F2" modified="2014-10-01" version="1">MEVSVEMEKFLCHLLLDHNKPISERFRALFSLRNIRGPTPRDALILATRDSSNLLAHEAAFALGQMQDGEAIPALELVLSDLSLHPIVRHEAAEALGAIALERNIPLLKKSLISDPAQEVRETCELALSRIEELRDHGSVDPSSAEPSPFLSVDPAAPASCSSVQELRDTLLDEKKGMYERYAALFALRNNGGEEAVTAIIESLGSRSALLRHEVAYVLGQLQNKRASDALSRTLRDTNEHPMVRHEAAEALGSIADDECLSLLEEFAKDPEPIVSQSCEVALSMLEFEKLGKSFEYLFMQAPKVELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2C3</accession>
    <name>A0A068V2C3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00042250001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2C3"/>
    <dbReference type="STRING" id="49390.A0A068V2C3"/>
    <dbReference type="Gramene" id="CDP14791">
        <property type="protein sequence ID" value="CDP14791"/>
        <property type="gene ID" value="GSCOC_T00042250001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2C3"/>
    <dbReference type="OMA" id="HISMQQG"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2C3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000043">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000021">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF380">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="132"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP14791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="699" mass="77674" checksum="DA1FB9618B0A52FE" modified="2014-10-01" version="1">MGNLCGKSSSTIKDGGESPNGRKLAKASSQTDLTRAVSSRRDESFRLKKKFNSGEIKIHMIDRKLSGSRRVRDDYYDKNKENSGALGNYYPGPGSVPKGLEGEQVAAGWPSWLASAAGEAIKGWLPRKADTFEKLDKIGQGTYSSVYKARDLTRNKLVALKRVRFDNMDTESVKFMAREILILRRLDHPNVIKLEGLVASRTSSSLYLVLEYMEHDLTGLASLPGVRFSEPQVKCYMQQLLSGLDHCHTHSVLHRDIKGSNLLLDNHGCLKIADFGLATSYDRNQKIPLTSRVVTLWYRPPELLLGASHYGAAVDLWSAGCILGELYAGKPIMPGRTEVEQLHKIFKLCGSPSEEYWRKAKLPHSTVFRPQQTYKRHLTETFKDFPPAAMGLMETLLSIDPAERGSAAVALKSEFFKTEPFACDPSTLPKYPPSKEIDAKLREEEAKRQGAQGVKGSKDLRAVPVPDANAELVSSMKRNAHSKNRSEQFNRHKEETSRGFPADPPRLSKGVIETRKATLEHPPQRVSYSGPLGPASGWAMSGKKYDDISFVSNKADLSTLSGLVASRTLPSEDSREKYGSQQVEIANQVKESLNLSGEPMKKHDQKHRMENLASSHHLETGRATKGPVLGHPSKATKIHFSGPLGVPPNKVDQMLKEHDRQLQEAVRRTRIERTRVGKVEGQEMQMTANPVYASTQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2D8</accession>
    <name>A0A068V2D8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00042487001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="HG739177">
        <property type="protein sequence ID" value="CDP14970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068V2D8">
        <property type="interactions" value="2909"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2D8"/>
    <dbReference type="Gramene" id="CDP14970">
        <property type="protein sequence ID" value="CDP14970"/>
        <property type="gene ID" value="GSCOC_T00042487001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2D8"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2D8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP14970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1284" mass="146027" checksum="A9A40B00F02CA48A" modified="2014-10-01" version="1">MQDDLTHQLAMVIRHNENLKRQERNGAPAHIISEFAQLLQFHIATYFDNELPGQPRATQRSGRPIKSICSRLKAKEGRIRGNLMGKRVDFSARTVITPDPTINIDQLGVPWSIALNLTYPETVTPYNIERLKELVEYGPHPPPGKTGAKYIIRDDGQRLDLRYLKKSSDQHLELGYKARFCNILIRVERHLNDGDFVLFNRQPSLHKMSIMGHRIKIMPYSTFRLNLSVTSPYNADFDGDEMNMHVPQSFETRAEVLELMMVPKCIVSPQSNRPVMGIVQDTLLGCRKITKRDTFIEKDVFMNILMWWEDFDGKIPAPAILKPRPLWTGKQVFNLIIPKQINLQRNAAWHQDDEPGPITPGDTQVRIEKGELLTGTLCKKALGTSTGSLIHVIWEEVGPDAARKFLGHTQWLVNYWLLQNGFSIGIGDTIADAQTMEKINETISHAKNDVKELIRKAQEKALEAEPGRTMMESFENKVNQVLNKARDDAGSSAQKSLSESNNLKAMVTAGSKGSFINISQMTACVGQQNVEGKRIPFGFIDRTLPHFTKDDFGPESRGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTSETGYIQRRLVKAMEDIMVKYDGTVRNSLGDVIQFLYGEDGMDSVWIESQKLESLKVKKGEFDSMYKYEIDDPNWNPDYMLPEAVEDLKTIREIRSVFEAEFQKLEADRLQLGTEIATTGDNTWPLPVNIRRLVSNAQKTFKIDFRRPSDMHPMEIVEAVDKLQERLKVVHGDDYLSAEAQKNATLFFNILLRSALASKRVLNDYRLTREAFDWVIGEIESRFLQSLVAPGEMIGCVAAQSIGEPATQMTLNTFHYAGVSAKNVTLGVPRLREIINVAKKIKTPSLSIYLKHKASETKEKAKKVQCALEYTTLRSVTQATEVWYDPDPMSTIIPEDVEFVKSYYEMPDEDIDPDKISPWLLRIELNREMMVDKKLSMADIAEKINLEFDSDLTCIFNDDNADKLILRIRIMNDEAPKGELNDESAEDDVFLKKIESNMLTEMALRGIPDINKVFIKQAKVNKFTQEEGFKTDSNEFMLDSEGVNLLAVMCHEDVDASRTTSNHLIEVIEILGIEAVRKALLDELRVVISFDGSYVNYRHLAILCDTMTYRGHLMAITRHGINRNDTGPLMRCSFEETVDILQMAALPRKRDISSCLTLDEIQSIMSTLSFVTARRPTFLAIHVFPLPDFPERTMVDTFRSMRSSRILVISCSTLFWSIANVPLQNTCIMVQWLHIPARRKEIVILLKSKLAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2R1</accession>
    <name>A0A068V2R1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042227001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2R1"/>
    <dbReference type="FunCoup" id="A0A068V2R1">
        <property type="interactions" value="2266"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2R1"/>
    <dbReference type="Gramene" id="CDP14774">
        <property type="protein sequence ID" value="CDP14774"/>
        <property type="gene ID" value="GSCOC_T00042227001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2R1"/>
    <dbReference type="OMA" id="LCNQYDS"/>
    <dbReference type="OrthoDB" id="1876367at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2R1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35497">
        <property type="entry name" value="ACYL-UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35497:SF1">
        <property type="entry name" value="ACYL-UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58649" checksum="349EC2D66AE3944B" modified="2014-10-01" version="1">MAGRKEVGFLNASGVNLKEQLARTTLRNARLQGHTYVDLRKDGKKSIFFCTLCLAPCYSDSILYNHLKGSLHCERLAAAKATLLKPNPWPFDDGVLFFDDSSERDELPVSKRDNLQLLDNNDYDESSLAIVSYHEHLENNSNGHASHDDIGPSPTNLTDTFCSQLVIPGVLCKDEVSQLEVSYLGVAQIAARFCEKNGIINEIRRIWCEWLGRKDCDGEDTLMVLEHDFAIVTFPYSYNLGRKGLLDDLKYLLPPSPYSESEENSGGRNRKRKSFSDPEDVSESLANQYDSSGEESQNSNSCNKKLLLDGYDDQLLHSRVLSSKTLRKELRRQQQVASERMCDICQQKMLPGKDVATLLNRSTGRLVCSSRNLTGAFHVFHVSCLIHWILLCEMEIYAKQFDAAKTKRRPRRKAGTKQSESGKFSEIKGIRKQIYSSFCPECQGTGVNIDGNELEKPTVPLSEMFKYKIKASDAHRAWMKSPEVLPNCSTGFYFPAQSEDMYEEKVSPLKLLHFYRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5A7</accession>
    <name>A0A068V5A7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042630001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5A7"/>
    <dbReference type="FunCoup" id="A0A068V5A7">
        <property type="interactions" value="1824"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5A7"/>
    <dbReference type="Gramene" id="CDP15073">
        <property type="protein sequence ID" value="CDP15073"/>
        <property type="gene ID" value="GSCOC_T00042630001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5A7"/>
    <dbReference type="OMA" id="MSTRYAI"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5A7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45523:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45523">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63845" checksum="779705598E523B9C" modified="2014-10-01" version="1">MSKDAEAMEAEGKQFKRLGKCRSKSKLDYPLDCGADADADQSGQTMSSLREEKVSSLRTGLVHVARKMPKNAHAHFVLGLMYQRMGQAEKAVVAYEKAAEILIRSEEEIDRPELLSLVRIHHAQCILLGSLEECKSDKELEPKELDDIILKLRESMDSDIRQAPVWNTLGLVLLKTGRFQSAISVFSTLLAVEPNNLDCLGNLGIAYFQSGNMELSEKCLQDLILKDQNHPSAFINYAALLLCRYGSLISGAGAGANDGGASEEQVTAANVAKECLLAAVKSDPRAAHLWSNLSNAYFLMGDHRSASKCLEKAVKLEPNCLATRYAVGVHRIKDAERSQNPSEQLSWAGNEMASILREGESSVIEPPIAWAGLAMVHKAQHEIAAGFDIENDDLLEIKERATDSLKQAIAQDPDDAVQWHQVGLHGLCTQQFKTSQTYFKAAVARLKECSYAWSNLGISLQLSDDSPHAEEAYKRALSLATSQQAHTVLSNLGNLYRQLRQYERAKAMLTKSLELQPGYAPAYNNLGLVFVAERRWEEARYCFNKAFQTDPLLDAAKSNMIKAANMCRVYSTLNSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6I5</accession>
    <name>A0A068V6I5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BURP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017214001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6I5"/>
    <dbReference type="STRING" id="49390.A0A068V6I5"/>
    <dbReference type="Gramene" id="CDP16139">
        <property type="protein sequence ID" value="CDP16139"/>
        <property type="gene ID" value="GSCOC_T00017214001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6I5"/>
    <dbReference type="OMA" id="ITECEDK"/>
    <dbReference type="OrthoDB" id="654134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6I5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF2">
        <property type="entry name" value="BURP DOMAIN PROTEIN RD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01045">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BURP" evidence="1">
        <location>
            <begin position="126"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="342" mass="37747" checksum="720EB3D20A219D66" modified="2014-10-01" version="1">MVLVLLLSHLNILGSSTVIAGSYVLAFYCGYYCLMDLLKLLCFLTSVSLGIAAEHADLEVYWKSKLPNTPMPKAVRDIIQNGKPPGVGALSASPQAIPFRYGRYMIRYGKNPTEGQLLNHQNVTVFFLKMDLHGGSIMNLHFVNLLENTAAFLPRQVADSIPFSSKSVPEILNKFSVNPNSVQAEAIKETIADCEEPGIEGEDKRCATSLESMVDFTTSKLGKNVGAISTEAQKPDPKILKYVIVDVSKLNNDDKAIVACHKQNYVYAVFYCHTLQHTDAYRVNLVGADDGAKVKAVVVCHQDTSAWNPKHVAFQLLKVKPGNVPICHFLPEDHFVSWALKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6P6</accession>
    <name>A0A068V6P6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="4">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00018123001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="4"/>
    <dbReference type="EMBL" id="HG739205">
        <property type="protein sequence ID" value="CDP16326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6P6"/>
    <dbReference type="FunCoup" id="A0A068V6P6">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6P6"/>
    <dbReference type="Gramene" id="CDP16326">
        <property type="protein sequence ID" value="CDP16326"/>
        <property type="gene ID" value="GSCOC_T00018123001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6P6"/>
    <dbReference type="OMA" id="HYEFKED"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6P6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518:SF3">
        <property type="entry name" value="4-ALPHA-GLUCANOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP16326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="712" mass="82903" checksum="7D5F29857BFA42EC" modified="2014-10-01" version="1">MREMPWRGAGVAIPMFSVRSEEDLGVGEFLDLKLLVDWAVESGFHLVQLLPINDTSVHGMWWDSYPYSSLSVFALHPLYLRVQALSDKIPEEIKQEIEKARSQLDLKDVDYEATMAAKLSIAKKVFALEKDMILNSSSFQNFFAENKDWIKPYAAFCFLRDFFETSERSQWGCYAQFSEAKLEKLVSKDSLHYEIICFHYYIQFHLHIQLSEAAEYARTKGVILKGDLPIGVDRNSVDTWVYPNLFRMNTSTGAPPDYFDKNGQNWGFPTYNWEEMSKDNYAWWRARLLQMAKYFTAYRIDHILGFFRIWELPDHAMTGLCGKFRPSIPLSQEELEKEGIWDFDRLTRPCIRRELLENKFGASWAFVASIFMKESQKDVYEFKEDCNTEKKIASKLKSCLEKSMMLESEEKLRLQLFDLLRDIVLIRDPEDPRKFYPRFSMEDTSNFRELDEHSKNTLRRLYNDYYFHRQESLWRQNAMKTLPVLLNSSDMLACGEDLGLIPSCVHPVMQELGLIGLRIQRMPSEPGLEFGIPSQYPYMTVCAPSCHDCSTLRAWWEEDEGRRLRFFQTFLGSNNSPPDQCIPEIAYFIIQQHVEAPSMWSIFPVQDLLALKEEYTTRLAVEETINDPTNPKHYWRYRVHVTLESLLKDKDLITVIKDLVRGSGRSYPLQEPEVSEGKGTVPEKQQAANGLEKVPQITQTNGISKKETVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6R4</accession>
    <name>A0A068V6R4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00018180001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="HG739206">
        <property type="protein sequence ID" value="CDP16351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6R4"/>
    <dbReference type="FunCoup" id="A0A068V6R4">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.A41"/>
    <dbReference type="Gramene" id="CDP16351">
        <property type="protein sequence ID" value="CDP16351"/>
        <property type="gene ID" value="GSCOC_T00018180001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6R4"/>
    <dbReference type="OMA" id="NRFAWNK"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6R4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000001">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000030">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF408">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104043" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP16351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="492" mass="55867" checksum="D25DC05645779F07" modified="2014-10-01" version="1">MEIKTTRFILLPALLFILFRVQTFGKTHREADYHHLKARLNPQSNVERSSYFPAFDAPAKPSNQKGLKEKDRIDRLPGQPHVGFKQYGGYITINETAGRAFFYYFVEAQGRKKPEDVPLLLWLNGGPGCSSLAYGAFQELGPFRVGSNGKTLFKNRFAWNYVANVLFLESPAGVGFSYSNTTSDFVSGGDRKTAADNYIFLLNWLERFPEYKNRDFYISGESYAGHYVPQLAHNIVYHNKKANRTIINLKGILIGNAVINDATDDPGMYDYFASHALISPETVKKIHKFCNFSEAELSANCQNILSVADGVFDEVDIYNIYYPRCFDDSLTSVPKQFSILEFDECSEYYGHSYFNHPNVQEALHANVTKIPYDWQPCSDVLQNWTDWQSTVLPFLKEFLANGLKVWIFSGDVDGRVPVTGSQYAIEALNVSIVTPWQPWYRDLEVGGYVQIYQDNLTFVTVRGAGHQVPSYKPDRALSLISHFISGIPFPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V828</accession>
    <name>A0A068V828_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00019113001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="10"/>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V828"/>
    <dbReference type="FunCoup" id="A0A068V828">
        <property type="interactions" value="1976"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V828"/>
    <dbReference type="Gramene" id="CDP16654">
        <property type="protein sequence ID" value="CDP16654"/>
        <property type="gene ID" value="GSCOC_T00019113001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V828"/>
    <dbReference type="OMA" id="TLIYDCL"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V828"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000013">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="11">
        <location>
            <begin position="35"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP16654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="513" mass="58627" checksum="ADC3F456F91C3DE6" modified="2014-10-01" version="1">MASAAWSIEKRASFKTESSVGDDDNVPDTGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARTKLSDDDLRDRIRGYLSHGKDNGEELSKFLQLIKYVSGAYDAEEGFRALDKAIFEHEVSTKSSEGSARRLFYLALPPSVYPSVCKMIKLYCTNKSDLGGWTRIVVEKPFGKDLASAEQLSSQIGELFDEPQIYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIDNVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQVFCLIAMEKPISIRPEHIRDEKVKVLQSVEPIKEEEVVLGQYEGYTADPTVPDNSNTPTFATVILRIHNERWEGVPFILKAGKALNSRKAEVRVQFKDVPGDIFRCQKQGRNEFVIRLQPSEAIYMKLTVKQPGLEMSTVQSELDLSYRQRYSGVTIPEAYERLILDTIRGDQQHFVRRDELKEAWEIFTPLLHRIDRGEKKTVLYKPGSRGPTEADELLQRAGYVQTHGYIWIPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8H5</accession>
    <name>A0A068V8H5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00017288001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8H5"/>
    <dbReference type="Gramene" id="CDP16193">
        <property type="protein sequence ID" value="CDP16193"/>
        <property type="gene ID" value="GSCOC_T00017288001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8H5"/>
    <dbReference type="OMA" id="YHHENGS"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8H5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17416">
        <property type="entry name" value="MFS_NPF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="62954" checksum="28A2AF1112831BCE" modified="2014-10-01" version="1">MITKPLLKDDHDCFSAKGGFRTMPFILANEAFAQVASCGLQPSMILYLTGEYHLNMATGSNIIFLWSAATNFMPLLGATVADSFLGRFRMILFGCVISLLGMALLWLTSMIPQVKPPPCHESNKNCSSATSFQLSLLCSCFGLMSIGFGGIRSSSLAFGADQLQKAGGHNNGRVLESYFSWYSALSTISLLIAYTCIVYVQENLGWQVGFGIPVMLMLLSTLSFSLASHLYVKLKAKSSLIVEMLQVAVASYRKRHIELPTESSKMLYHHHRGPSICLPSEKLRFLNKACISLDPEKDLTTDGTAADPWSLCTVNQVEDLKSILKVIPLWSTGMIMSVNNSQLSFSVLQAKFMNRKFGPNFEMPAGSCSMFAVVGAVLWIPFYLQIILPVASRILGRPVHPSTRERMGIGVALSFVGMIVAATVELKRRSLAIREGYSDDSAAVVDISLLWLLPQSFLIGAGAIANMVAQNEFYYSEFPRSMSSISCTLSLLGISAANLVSSFLMNAIDKLSKLGGKESWISTNVNKGHYDYYYWVLAGLSMLNMIYFLICNKAYGPGKEDKKETTFHEQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8R0</accession>
    <name>A0A068V8R0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">galactinol--sucrose galactosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00019447001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.82" evidence="2"/>
    <dbReference type="EMBL" id="HG739223">
        <property type="protein sequence ID" value="CDP16874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8R0"/>
    <dbReference type="STRING" id="49390.A0A068V8R0"/>
    <dbReference type="Gramene" id="CDP16874">
        <property type="protein sequence ID" value="CDP16874"/>
        <property type="gene ID" value="GSCOC_T00019447001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8R0"/>
    <dbReference type="OMA" id="QCDVFTV"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8R0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000504">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF26">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP16874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="835" mass="91991" checksum="1ED56134B115D118" modified="2014-10-01" version="1">MTCPSSTTLTATTSRARTSLLLQLKLGCHHWSPSRSRSWTCLRYGHGYIGGEGGGGGSLLGTAARRHNVSKNRAVRGISMFLNTRPKPVVKDGVLSFDGTEALKDMPHNIVIKPWYDSSSAAFLGAAFTDESESSSSSTSRLVFKLGVIRETRLLCLFRFKIWWSIPRVGNSASDIPVETQMLLLEAPHDHSASSDGTTAYILFLPLLDGETRSSLQGNSADELQVCVETGDPALLASESTKAVFVNYGGNPFDLMKESMKILQKYSRTFALRETKQASGIMPGMLDWFGWCTWDAFYHDVNPQGIKDGLSSLSKGGTPARFLIIDDGWQDTTNEFQKEEEPFVEGSQFGARLMSIRENMKFRKASSEASSVPNSLKEFISDIKSTFGLKYVYVWHALMGYWGGLHLDAPGTQKYNPTLKYPVQSPGNLAHKRDIAMDSMEKYGVGTIDPARIFEFYDDLHRYLASQGVDGVKVDVQNILETVATGSGGRVSLTKHFQQALEESIARNFQDNGIICCMGQSTDSIYNSKKSAITRASDDYYPKNPNTQTLHIAAVAYNSIFFGEVVVPDWDMFYSRHNAAEYHAVARAVGGCGVYVSDQPGQHDFNILRRLVLPDGSVLRAKYPGRPSRDCLFCDPVMDGKSLLKIWNLNKCTGVIGIFNCQGAGSWPGLEDSPKMNSPEISGKISPSDIDYFEEVSGKSWKGDCAVFSFKSASLFRLAKHGKLDITLGTLQCDIFTVSPIKVYGKKVEFAPIGLINMYNSGGATDAIEVITEFSDFGIRIKGRGPGIFGAYSNLKPKSCSLNLMDEGFEFRSEDCLLTIPIPSSTDVWEVAVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V933</accession>
    <name>A0A068V933_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00018351001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739210">
        <property type="protein sequence ID" value="CDP16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V933"/>
    <dbReference type="FunCoup" id="A0A068V933">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V933"/>
    <dbReference type="Gramene" id="CDP16443">
        <property type="protein sequence ID" value="CDP16443"/>
        <property type="gene ID" value="GSCOC_T00018351001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V933"/>
    <dbReference type="OMA" id="SEWAYIR"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V933"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658697" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="473" mass="51069" checksum="962313F105DE8FD5" modified="2014-10-01" version="1">MDIALLLFWSTTILGLSHNAEGSLFSIREATVHDIRIALDHNRLTSRELVEFYLKEIRRLNPVLNGVIEDNIATKDKLNTTAGSYALLGSVVPQDAGVVKKLRRAGAIILGKASMTEWAAARSSGVPNGWNARRGQSVNPYIKSANPCGSSTGSAISVAANMVAVTLGTETAGSILCPSSYNSVVGIKPTVGLTSRAGVVPYSPRQDTVGPICRTVSDAVYVLDAIVGFDPADAVATKKASKYIPHRGYLQFLKSDGLKGKRLGIPRYSFVGFSNSSVALKAFETHFHVLRKRGAVLVDIVDTASFDTIIISMLHDESKAVIVEFKLALNAYLKQLITSPVRSLADAIVFNKDHSKLEKIKEYGQDIFEAAEKTNRIGILERQILLNLTRASKNGFEKLMKENKLDALVTPISTIVYAISAGGYPGINVPAGYDTDGTPYGISFGGLKGSEPKLIEIAYDFEQATKIRKPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9J9</accession>
    <name>A0A068V9J9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter CorA-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00004081001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739238">
        <property type="protein sequence ID" value="CDP17326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9J9"/>
    <dbReference type="FunCoup" id="A0A068V9J9">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9J9"/>
    <dbReference type="Gramene" id="CDP17326">
        <property type="protein sequence ID" value="CDP17326"/>
        <property type="gene ID" value="GSCOC_T00004081001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9J9"/>
    <dbReference type="OMA" id="FHTTERF"/>
    <dbReference type="OrthoDB" id="1931410at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9J9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46950">
        <property type="entry name" value="MAGNESIUM TRANSPORTER CORA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46950:SF9">
        <property type="entry name" value="ZINC TRANSPORT PROTEIN ZNTB-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59617" checksum="2DB00C03DEEC3BA1" modified="2014-10-01" version="1">MEYSMNGMSEDHSSLGSSTKRPEGHKTRYNKDVMPGSELWTDGLICAFEFRKSMINSKDPATLHEIGASGNGALDSDADRPNMQSDCLHSVERFEGSHWIPIGWARISELVQTVQIDAGWSEQQVDLMDDEEDLTVADLAAPYWERQAGPTWWCHVAAGHPCVDAWLNSAQWLHPAISVALRDENRLISDRMKHLLYEVPVRVAGGLLFELLGQSAGDPYADEDDIPIVLRSWQTHNFLISALHVKGSASRINVLGIAEVQELLVAGGYNAPKTVHEVIAHLACRLARWDDRLFRKSIFGVADEVELKFMNRRNHEDLNLFGIILNQEIRKLSTQVIRVKWSLHAREEIVFELLQHLRGNTARSLLEGIRKSTREMIEEQEAVRGRLFTIQDVMQSTIRAWLQDRSLRVTHNLTVFGGCGLVLTIITGLFGINVDGIPGAANTPYAFGLFSGVLVFLGIVLIVIGLLYFGLKNPISEEKVEIKKLELQEMVKMFQHAAETHAQVHKPVSRHNLPPTAADKFLQEADYLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9P5</accession>
    <name>A0A068V9P5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TCTP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00000655001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739232">
        <property type="protein sequence ID" value="CDP17189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9P5"/>
    <dbReference type="FunCoup" id="A0A068V9P5">
        <property type="interactions" value="2309"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9P5"/>
    <dbReference type="Gramene" id="CDP17189">
        <property type="protein sequence ID" value="CDP17189"/>
        <property type="gene ID" value="GSCOC_T00000655001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9P5"/>
    <dbReference type="OMA" id="CAMITEG"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9P5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000003">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP17189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="168" mass="18857" checksum="DDD389CB5981D428" modified="2014-10-01" version="1">MLVYQDLLSGDELLSDSFPYKEIENGMLWEVEGKWVVQGAVEVNIGANPSAEGGEEDEGVDDQAVKVVDIVDTFRLQEQPAFDKKQFVAYIKKYIKNLSPKLEPEKLDAFKKNIEGATKYLLSKLSDLQFFVGESMHDDGSIVFAYYKEGATDPTFLYLAPGLKEVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9Y0</accession>
    <name>A0A068V9Y0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00004073001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Cold-regulated 413 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739238">
        <property type="protein sequence ID" value="CDP17319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9Y0"/>
    <dbReference type="FunCoup" id="A0A068V9Y0">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9Y0"/>
    <dbReference type="Gramene" id="CDP17319">
        <property type="protein sequence ID" value="CDP17319"/>
        <property type="gene ID" value="GSCOC_T00004073001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9Y0"/>
    <dbReference type="OMA" id="YQATNLR"/>
    <dbReference type="OrthoDB" id="1928310at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9Y0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008892">
        <property type="entry name" value="COR413"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33596:SF17">
        <property type="entry name" value="COLD-REGULATED 413 INNER MEMBRANE PROTEIN 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33596">
        <property type="entry name" value="COLD-REGULATED 413 PLASMA MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05562">
        <property type="entry name" value="WCOR413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="163" mass="17854" checksum="C9A3D6D6E90E11D1" modified="2014-10-01" version="1">MKKKRSHGLSAVCYAASLTTTNLEWVAAVCTAILTLSRGTPIHKSFLVPLFALQAPNSIVSWIRGEYGYWTAFLALLVRLFFSIPGELELLYIALLLVIVAPYQVMNLRGQQEGVIISLIIAAYLAFQHFSRAGSLRRAFDQGSVIASLAISCIVVVPCLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDV6</accession>
    <name>A0A068VDV6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00011299001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739391">
        <property type="protein sequence ID" value="CDP18926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDV6"/>
    <dbReference type="STRING" id="49390.A0A068VDV6"/>
    <dbReference type="Gramene" id="CDP18926">
        <property type="protein sequence ID" value="CDP18926"/>
        <property type="gene ID" value="GSCOC_T00011299001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDV6"/>
    <dbReference type="OMA" id="HYGCLED"/>
    <dbReference type="OrthoDB" id="1658010at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDV6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000146">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase IOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45631">
        <property type="entry name" value="OS07G0107800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45631:SF212">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP18926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="318" mass="35069" checksum="2B7791AF1AC36D52" modified="2014-10-01" version="1">MFKCSEIIEITNTFRTVIGRGGSGIVYLGCLEDGSNVAVKMLSSSSATRGQKQFQSEVEILIKIHHTNLVSFVGYCAEGRTMALICEYMANGNLRQHLSGKNLNPLSWKERVHIALDAAQGGLEYLHDGCNPPIIHRDLKSANILLNQKLQAKLADFGLSRIFASESDTHVTTAVAGTAGYLDPEYNYTFKFNEKSDVYSLGIVLLELITGKPAIIKGTDDVNIHIVEWVNKRVERGDIHEIMDPKLKGKFNINSAWKFLEAAMTCTMAMASQRMSAMELLVELKQCLAIELSEEIASRAADFPQDGGLEIDTAPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEC3</accession>
    <name>A0A068VEC3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL6c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00002098001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739428">
        <property type="protein sequence ID" value="CDP19076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEC3"/>
    <dbReference type="Gramene" id="CDP19076">
        <property type="protein sequence ID" value="CDP19076"/>
        <property type="gene ID" value="GSCOC_T00002098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEC3"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEC3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000002">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_uL6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="8">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="8">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP19076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="226" mass="25017" checksum="3EA43581E383DBB6" modified="2014-10-01" version="1">MATSLGASSPNCNLKSPFTGMRVPRIAVVGYQHAKFVTRRTIVECKESRIGKQLIEVPSNVTLTIDGQDLKVKGPLGELALTYPKEILLQRDDSGLRVRKSIETRRANQMHGLFRTLTDNMVVGVSKGFEKRLQLVGVGYRATIEGKDIVLSLGFSHPVRMTIPDGLQVKVEDNTRVIVGGFDKSAIGQFAASIRKWRPPEPYKGKGVKYADEIIRRKEGKAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEN6</accession>
    <name>A0A068VEN6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_339</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00008316001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739423">
        <property type="protein sequence ID" value="CDP19057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEN6"/>
    <dbReference type="STRING" id="49390.A0A068VEN6"/>
    <dbReference type="Gramene" id="CDP19057">
        <property type="protein sequence ID" value="CDP19057"/>
        <property type="gene ID" value="GSCOC_T00008316001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEN6"/>
    <dbReference type="OMA" id="VELEPWC"/>
    <dbReference type="PhylomeDB" id="A0A068VEN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027728">
        <property type="entry name" value="Topless_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083:SF48">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="14423" checksum="B44454FE32630F03" modified="2014-10-01" version="1">MPHLPTCVCGMKTPVGENSGKILHSGLWQGVPRESRGTITDATFPCDGIYIFASLEDGSIFILTSVELEPWCQINPTAYLPSNPSTRLHPLAIDAHPSESNQFVVGLTDGGVCIVEPPHVLVLWMWHAAFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF78</accession>
    <name>A0A068VF78_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00006637001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the plant Proton pump-interactor protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739453">
        <property type="protein sequence ID" value="CDP19179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF78"/>
    <dbReference type="STRING" id="49390.A0A068VF78"/>
    <dbReference type="Gramene" id="CDP19179">
        <property type="protein sequence ID" value="CDP19179"/>
        <property type="gene ID" value="GSCOC_T00006637001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF78"/>
    <dbReference type="OrthoDB" id="1745435at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055282">
        <property type="entry name" value="PPI1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32219:SF2">
        <property type="entry name" value="PROTON PUMP-INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32219">
        <property type="entry name" value="RNA-BINDING PROTEIN YLMH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP19179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="191" mass="21878" checksum="7C3509D73861DD67" modified="2014-10-01" version="1">MGLSEPITFGSHGMDEPAKGEKNKAAEVNFPKDAVDEWPAPKQIHSFYFVKYRLHEDQKLKVKLDQADTGLQKKNQARSQLIEKLRKLKADRAQKIGFLKGLNKENKQYRDLIDEKKKEREPLQQALGQLHGGRDTGSGICSSEEELNHRVSFDVLYFSSAIYMLLFPYPPTCFLLCLQSFAFHVLVFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF96</accession>
    <name>A0A068VF96_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012953001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739315">
        <property type="protein sequence ID" value="CDP18373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF96"/>
    <dbReference type="FunCoup" id="A0A068VF96">
        <property type="interactions" value="3231"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VF96"/>
    <dbReference type="Gramene" id="CDP18373">
        <property type="protein sequence ID" value="CDP18373"/>
        <property type="gene ID" value="GSCOC_T00012953001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF96"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF96"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000375">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="106"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="311"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132524" checksum="C955052A453529C7" modified="2014-10-01" version="1">MEDSGMVNNVAAALAAALDWRSSGDARKAAYSYLESVKAGDIRHLANASFTLVKKDWSSEIRLQAFKMLQHLVRLRWDELNPTEKRNFAKMAVDLMSEMANPSEEWALKSQTAALVAEVVRREGVSLWQELLPSLISLSNQGPTQAEIVSMMLRWLPEDVMVHNEDLEGDRRRLLLRGLTESLPDILPLLYSLLERHFGAALAEASRQQSDIVKQHAATVTATLNAVNAYAEWAPLPDLAKYGIIHACGFLLSSPDFRLHACEFFKFVSPRKRPIDGTSEFDSAMGQIFQVLMHVSRDFLAKSSSSIAMDESEFEFAEYITESMVFLGSSNLQSVAGDAGIVSSYLQQMLGFFQHCKLALHCQSLLFWLALMRDLVSKSKIFPTNNTVEKSNSSSGQADIEKKKILAFVNDDIFNAILDASFQRMLKKEKVHPHSAFLVGTLELWSDDFEGKGDFGQYRSRLLELIRFVASEKPLIAATKISERINAIVKSLLLAPTPAQELATMESMQLPLENVAIAVFDGSNDFGRMPSEVQLALCRIFEGLLQQLLSLKWIEPALVQVLGRYLDALGPFLKHHPDAAGTVINKLFELLTSLPLIVKDPSVSAARHARLQICTSFIRIAKAADKSLLPHMKGIADTMAYLQKEGTLLRGEHNLLAEAFLIMAASAGVQQQQQVLAWLLEPLSKQWTQVEWQEAYLSEPAGLVRLCAETSFMWSLFHTVTFFERALKRSGVRKGNFNLQNISTALHPMASHISWMLPPLLKLLRAVHSLWSPSVAQALPAEVKGAMIMSDVERTSLLGEGSLRLPRSALTFSDGSQLDMHKEGHSEPTEIDIRNWLKGIRDSGYNVLGLSATVEDSFFKYLDSDSIALALMENIQSMEFRHIRQLVHSSIIPLVRCCPSDLWEGWMEKLLHPLLFHSQRALSSSWSSLLQEGHAKVPDLHGIPAGSDLKVEVMEEKLLRDLTREICSLLSVLASSGLNSGLPSLEQSGQVARVDVSTLKGLDAFVSSSMVGFLLNHKSLALPALQISLEAFRWTDAEAVTKVAFFCGAVVLLSIVTNNADIQEFVCKHLFSAIIQGLALESNAIINADLVGLCREIFIYLSDRDPAPREILLSLPCITQQDFLAFQEALSKTSSPKEQKQHMKSFLLLATGNQLKALASQKSATVISNVSGRPRNLGPAPESNLTDGGDAIGLAAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGM5</accession>
    <name>A0A068VGM5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DH200=94 genomic scaffold, scaffold_636</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00012631001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739720">
        <property type="protein sequence ID" value="CDP19727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGM5"/>
    <dbReference type="STRING" id="49390.A0A068VGM5"/>
    <dbReference type="Gramene" id="CDP19727">
        <property type="protein sequence ID" value="CDP19727"/>
        <property type="gene ID" value="GSCOC_T00012631001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGM5"/>
    <dbReference type="OMA" id="KCKGRLP"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGM5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000020">
        <property type="entry name" value="Cytochrome P450 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF185">
        <property type="entry name" value="CYTOCHROME P450 87A3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658921" evidence="14">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP19727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="471" mass="53703" checksum="6121D48FA3D48A17" modified="2014-10-01" version="1">MLFACAIIALIILLFSHWVYRWRNPKCNGALPPGSMGLPIIGETIQYFTPYAKDDVPQFLQKRVSRYGPIFRTSLVGQPVIVSTDPEVNYHVFQQEGNAFRCSYTESVFRIIGKQSLVVHHGEFHKYLKNLILKLVSPEALREKLIYEMDGNTQKCLSSWSKLGKIDAKDGTAELVFKLAAKKILDYEESKAQKKLRDSYKAFMDGFISFPLNIPGTAFHACLQGRKKAMKAIKNTFEMRRSCNDATKVFVDHLLKEVEKEDTFLNEEIAMDLVFLLLFASHETTSTAMTLAMRFLNDHPAVLAELKREHENILKIRETEDSGVSWKEYKSMIFTHMVINETVRLANIAPGIFRKVVKEVEIKGYTFPAGWTLMVCPSSVHLDPNRYNDPLEFNPWRWEGQELHAGSKSFMAFGGGTRLCVGADFAKLQMAIFLHYLVTKYTWTVIHGGETIRKPGLLFPSGLHIEISENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGU8</accession>
    <name>A0A068VGU8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00010385001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739759">
        <property type="protein sequence ID" value="CDP19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGU8"/>
    <dbReference type="Gramene" id="CDP19779">
        <property type="protein sequence ID" value="CDP19779"/>
        <property type="gene ID" value="GSCOC_T00010385001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGU8"/>
    <dbReference type="OMA" id="EWENITP"/>
    <dbReference type="PhylomeDB" id="A0A068VGU8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF45">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="177"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="387"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="601"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="821" mass="94397" checksum="E2FE4C274A887A0E" modified="2014-10-01" version="1">MAELFVPKIIDQLSDVLVTQLGEKVNLVMGVEKEVANISSKLATIEKVLHDAERRRLKDRSVGIWLEKLEDITYEMDDVLDEWNFKIHGAKNERTQQNARLQATLWSKVRSFIPSLCSCLKQVPVRSDIALKIKSINEKLELTLKEGDQFKFISTGGIPDSQDFQRIMTTSIIDESEIYGAGGSGKTTLAQLLFNNDEVKNHFDLRNWICVSDPFDQKRIAKAILENAGKSSQESELDPLIQRIKETFSGKRFLLVLDDVWTEDDTKWKPFQDSLKDGALGSMALISDSDCWLIMQRLAFARKSGDLCKKVARIGQKIAEKCKGLPLAAKTMGSLLRFKDTVQQWQNVLDSEIWQLEEAAVELFPHLYLSYNELSPELKRCFSYCAVFPKDHVIDVEDLIWLWIAQGYVRPRRRGESLELVGLEYFNNLAMRSFFQELEKVETYYGLTEYMKCKMHDIVHDFAQFLTKNECHALDGTGRNSSSERPRHLTILEEGTEEEMFSSRVVDFGRLRSFITFPGIRRVVVPQNLFSRLKCVRTLTLSDCELDEIPAEIGRLIHLRHLNLSLNPFITLPEAICDLYYLETLNITLCRKLSNSDDLAILKDLNQLERLVIKIKGEVDFGSAKLGKKINMREMFLFFSDGTHFIETPSCIESMEPPPNLEQLMLVGYPGAQLPSWLVTKSHANNLTKLVIGRPHNISSLLALRKLSSLEELKLVRVEELKCLGKEFFGSSFSAEAVAFPNLRKLHFEDCNNWTNWEDLKIYDCKKLETLPHRILKKISSLKILDIRRCIKLRNRYSDKTGDDWIKVSHIPRVDISNKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHN9</accession>
    <name>A0A068VHN9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00011497001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG740078">
        <property type="protein sequence ID" value="CDP20201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHN9"/>
    <dbReference type="STRING" id="49390.A0A068VHN9"/>
    <dbReference type="Gramene" id="CDP20201">
        <property type="protein sequence ID" value="CDP20201"/>
        <property type="gene ID" value="GSCOC_T00011497001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHN9"/>
    <dbReference type="OMA" id="GREEVCF"/>
    <dbReference type="PhylomeDB" id="A0A068VHN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF44">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="87"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP20201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="40546" checksum="491628BDD630C37D" modified="2014-10-01" version="1">MQDVTLLTNCIVVLVVPREPEPVPSNHKISSSVIAGIVGSALVFGILILALSWALFRIRLRKLRGILEPLNPGFKNFDFSKLNAATNGFDRRNMIDVAGNVYRGELDGIQVAVKRLSEKSEEGAHEFITAIGTISALKHPNLATLMGSCTEQNQLLLVYKYMENVSLQHALFAEVKSELNWETRYKICLGVAEGLACLHESKLQVIHCNIKPTNILLDKDFTVKISDFEYSQFHDSKHSFVCRGHMSGEQIQGFPLTPKADVYSFGIITLEIVSGQEICPLGGREEVCFFFFFWAYKHQVEGNLTALVDPDLKSSNYEPDEAHTMLCLAMTCVNPTADDRPTMSSVVKTLKDSEKFGGKKKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI64</accession>
    <name>A0A068VI64_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_1080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00003964001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740164">
        <property type="protein sequence ID" value="CDP20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI64"/>
    <dbReference type="Gramene" id="CDP20292">
        <property type="protein sequence ID" value="CDP20292"/>
        <property type="gene ID" value="GSCOC_T00003964001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI64"/>
    <dbReference type="OMA" id="KIGVAMN"/>
    <dbReference type="OrthoDB" id="1927969at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VI64"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF774">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 85A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658676" evidence="3">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="205" mass="23506" checksum="40A4AFCA3370749E" modified="2014-10-01" version="1">MILMMLGIVHLMPCRCQLFDKWISRYCSRLDSRIRGRICLGTRLANSKRNFLWILRPDLVSGSSAILPSEFFEETKERSMFAGWCPQEKKVLSHPSVGGFLTHSGWNSTIESISYGVPLFCWPFFADQQTNCWFCCTKWGIGMELDNNVKRDEIESLVSELMAGEKGKEMKKKAMDWKKLAEMAVTDSNSNLENLIHQVLLNPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ25</accession>
    <name>A0A068VJ25_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_1411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00013328001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740495">
        <property type="protein sequence ID" value="CDP20594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ25"/>
    <dbReference type="STRING" id="49390.A0A068VJ25"/>
    <dbReference type="Gramene" id="CDP20594">
        <property type="protein sequence ID" value="CDP20594"/>
        <property type="gene ID" value="GSCOC_T00013328001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ25"/>
    <dbReference type="OMA" id="NCKEAVR"/>
    <dbReference type="PhylomeDB" id="A0A068VJ25"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="121" mass="13604" checksum="010E825FB5FE0B56" modified="2014-10-01" version="1">MEKAENLVELIEAQTHVWNAMFHFKKSACLGIPDVISNHGKPITLSDLISVIIIDSVMGSQIQDETSFETEFSLDMQMLVMLGPAKERTGKEWSKLFSDAGFSSYKVYPVLGMRCLIEVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ59</accession>
    <name>A0A068VJ59_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_1906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00004905001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740990">
        <property type="protein sequence ID" value="CDP20865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ59"/>
    <dbReference type="STRING" id="49390.A0A068VJ59"/>
    <dbReference type="Gramene" id="CDP20865">
        <property type="protein sequence ID" value="CDP20865"/>
        <property type="gene ID" value="GSCOC_T00004905001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ59"/>
    <dbReference type="OMA" id="ECKRTTH"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ59"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042300">
        <property type="term" value="F:beta-amyrin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF71">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="303" mass="35532" checksum="01F3A06AB884C58D" modified="2014-10-01" version="1">MCQVLGVYDWDGCNPLPPEFWLFPEFFPYHPAKMWCFCRSTYMPMSYLYGRKYRGPLTDLVLSLRQEIHVMPYDQINWNKARHDCCKEDLYCPHSFIQDFLWDTLNYCFEPIIRRWPCNKIRQRAMAKAIEHMRYGAEVSGYITTGCVEKSLQMMCFWAHDPDGDDFKYHLARVPDYLWLAEDGMKMQTAGSQVWDCVFASRAILASGMVDEYGDSLKKAHFYLKESQCKTNLKGDFKKMYRHFTKGSWTFSDQDQGLAVSDCTAEALKCLLRFSEMPQEIAGEKADVERLYDAVNICLYLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLI0</accession>
    <name>A0A068VLI0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_1329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005681001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740413">
        <property type="protein sequence ID" value="CDP20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLI0"/>
    <dbReference type="STRING" id="49390.A0A068VLI0"/>
    <dbReference type="MEROPS" id="I03.030"/>
    <dbReference type="Gramene" id="CDP20533">
        <property type="protein sequence ID" value="CDP20533"/>
        <property type="gene ID" value="GSCOC_T00005681001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLI0"/>
    <dbReference type="OMA" id="DATICVQ"/>
    <dbReference type="PhylomeDB" id="A0A068VLI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23375">
        <property type="entry name" value="beta-trefoil_STI_VvMLP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011065">
        <property type="entry name" value="Kunitz_inhibitor_STI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002160">
        <property type="entry name" value="Prot_inh_Kunz-lg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107:SF5">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00197">
        <property type="entry name" value="Kunitz_legume"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00291">
        <property type="entry name" value="KUNITZINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00452">
        <property type="entry name" value="STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50386">
        <property type="entry name" value="STI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656020" evidence="2">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="214" mass="23605" checksum="623C6D65397FA515" modified="2014-10-01" version="1">MMKASLLFILSFLVFSISVSTNSSFTSAAEAPEPVRDVAGKMLRTDRHYYILPAANVFDKFRGGGLTLSGIGKNTCPAAVFQETSEQKNGIPLAFLPVNPKKGVVRVSTDLNIKFAYPETCGQSPVWSIDNYVYPSGDSFVNIGGVVGNPGPKTLSSWFKIEKFGYQDYKLVYCPAVCSYCKVICKDVGIEYQNGKRRLHLTTDYPLRVVFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TL94</accession>
    <name>A0A068TL94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00014344001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TL94"/>
    <dbReference type="FunCoup" id="A0A068TL94">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TL94"/>
    <dbReference type="Gramene" id="CDO97105">
        <property type="protein sequence ID" value="CDO97105"/>
        <property type="gene ID" value="GSCOC_T00014344001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TL94"/>
    <dbReference type="OMA" id="TTSPWRY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TL94"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000591">
        <property type="entry name" value="RING-H2 finger protein ATL65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF21">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO97105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="433" mass="47416" checksum="2A80F1D675AEAD6B" modified="2014-10-01" version="1">MRIHPLAPSPAPAPVPSPHSKVPSSHTAAFPPPSSTSSSSSLSATTKTPPSSSSSPSKLPVEFSPPLIAMVVIIATAFVIITYSRVISRHFLRLHRLYRRRRRRRRYVPSSSASNIDSPPYPFDPSDAFHVFSPYGLDDSAIKTIPLSVHARKSSVHDCAVCLLEFEENDYVRTLPVCSHAFHVDCIDIWLKSHANCPLCRAGIFRPESPFVPVMAARIRPSLDDMMMESTILEPLAEIQPEESESTTVEEITQEPSPRINNTQSSEDQFNGRDFLLKRSYSFGFERNLGSERLVLEPVTASPWRYRRGGVGSFWSKRPSPFSSLTKSRVFSFRYYRGMNMKSPFFRRRGGGGGGGGGGVGGSFYPLSESSVRFGGSAASGGGGGSSRRSSKSFASPMFLRTSGGAAGGFFSSSRQRSGDPEALLSPDRYNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMZ0</accession>
    <name>A0A068TMZ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014636001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMZ0"/>
    <dbReference type="FunCoup" id="A0A068TMZ0">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMZ0"/>
    <dbReference type="Gramene" id="CDO97324">
        <property type="protein sequence ID" value="CDO97324"/>
        <property type="gene ID" value="GSCOC_T00014636001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMZ0"/>
    <dbReference type="OMA" id="TRIVCAH"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMZ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05381">
        <property type="entry name" value="CAP_PR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000006">
        <property type="entry name" value="Putative pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657151" description="SCP domain-containing protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="7">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="166" mass="18408" checksum="DD33B46B741C72FC" modified="2014-10-01" version="1">MTANMLSISLSLLCFLSSAFLVILPSHGQNSPQDYLDVHNAARSKVGVGPMLWDSTVAAYALNYANQRKGDCNLIHSNTDYGENLAKGCGNFSGAEAASLWVAEKPYSDYHQDACVGGRECLHYTQVVWRDSVRLGCARVQCLNKLWWFVICNYDPTGNYVGERPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN71</accession>
    <name>A0A068TN71_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00021657001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN71"/>
    <dbReference type="FunCoup" id="A0A068TN71">
        <property type="interactions" value="2972"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN71"/>
    <dbReference type="Gramene" id="CDO97765">
        <property type="protein sequence ID" value="CDO97765"/>
        <property type="gene ID" value="GSCOC_T00021657001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN71"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN71"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO97765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="10313" checksum="87D8AC7A3EECC65A" modified="2014-10-01" version="1">MASTKVQRIMTQPINLIFRFLQSKARIQIWLFEQKDLRIEGRIIGFDEYMNLVLEDAEEVNIKKKTTKQLGRILLKGDNITLMMNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNX8</accession>
    <name>A0A068TNX8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00015090001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNX8"/>
    <dbReference type="FunCoup" id="A0A068TNX8">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNX8"/>
    <dbReference type="Gramene" id="CDO97682">
        <property type="protein sequence ID" value="CDO97682"/>
        <property type="gene ID" value="GSCOC_T00015090001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNX8"/>
    <dbReference type="OMA" id="HPYENEY"/>
    <dbReference type="OrthoDB" id="2015206at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNX8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000363">
        <property type="entry name" value="Leucine-rich repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000328">
        <property type="entry name" value="Leucine-rich repeat protein kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000542">
        <property type="entry name" value="Leucine-rich repeat protein kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000453">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase HSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45974:SF266">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE HPCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45974">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657172" description="non-specific serine/threonine protein kinase" evidence="19">
        <location>
            <begin position="22"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="631"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDO97682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="953" mass="103984" checksum="D8950D8D5AE04233" modified="2014-10-01" version="1">MFARIQPYLLVIFVQVLVVAAITNPQDFAALQSLKSGWENAPPNWAGTDPCGSGWIGIGCSNSRVVSITLASVGLSGQVPGDIADLSELLTLDLSYNEGLTGSLPRTIGNLAKLTSLILVGCGFSGQIPDTIGSMKQLYTLSLNSNKFIGQIPPSIGALPKLHWLDLADNKLSGSIPVSNGTAPGLDMLVQTQHFHFGKNQLSGEIPSQLFSGNMSLIHLLLENNQLTGKIPSTVGLIQTLEVLRLDRNSLRGPVPQNLSKLTSVQELFLSNNNLNGPLPDLTGMTSLNYLDMSNNTFDASDFPPWISTLPSLTTLVMENTNLRGGVPETLFSLAQLQSVILKNNRLNGTLSLGSSYSNELQLIDLQNNTVKFYTEQAGGYGSIQIILVDNPICQETPQSYCIPPRQANSSYTTPSNCSRPQCRSDQVSSPSCQCAYPYTGTLFFRAPSFSYLGNLSTFLALQERLMFTFQSHQLPVDSVSLSNPSKNLDDYLTLSLEVFPSGLDYFNYTGISAIGFALSNQTFKPPPFFGPFFYRANGYQYFSGALSSSNKSSSSTAIIIGAAVGGSVLLLLLLVAGGYAFRQKRRAEIAAKHIDPFASWDRSKNSGGVPQLKGARNFSFEEVKKYTKNFSEANDIGSGGYGKVYRGTLPTGQLVAVKRAQQGSMQGALEFKTEIELLSRVHHRNVVGLVGFCFDQSEEMLVYEFIPNGTLKDSLSGKSGIRLDWMRRLRIALGAARGIQYLHVLANPPIIHRDIKSNNVLLDERLNAKVADFGLSKPMGSPDRTHVTTQVKGTMGYMDPEYYMTQQLTEKSDVYSFGVLLLELVTARAPIDKGKYIVREVKLAMDKTKDLYNLQELIDPVIVSSVAPGSLEKFVDLALDCVAEEGVNRPTMSEVVKEIESIMELAGLNPHTESASTSDNYDGARKGYEHPYSDDSLFVYSGAYPHSKLEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNZ6</accession>
    <name>A0A068TNZ6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-containing phosphotransfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021930001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNZ6"/>
    <dbReference type="FunCoup" id="A0A068TNZ6">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNZ6"/>
    <dbReference type="Gramene" id="CDO97976">
        <property type="protein sequence ID" value="CDO97976"/>
        <property type="gene ID" value="GSCOC_T00021930001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNZ6"/>
    <dbReference type="OMA" id="DGYMHQF"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000005">
        <property type="entry name" value="Histidine-containing phosphotransfer protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF43">
        <property type="entry name" value="HISTIDINE-CONTAINING PHOSPHOTRANSFER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="5">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="150" mass="17577" checksum="04C214C0610F7C2B" modified="2014-10-01" version="1">MERNQLRRKLANMRQSLFEQGYLDEQFTQLEELQDDANPNFVEEVVTLFYRDSARTIQNIEQALEKNPLDFAQLDSYMHQFKGSCSSIGAVKVKSESTQFRNYCKEGNAEGCRRTFHQLKKEYAALKKKLELYFQYARQAGPDETACRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPC5</accession>
    <name>A0A068TPC5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021687001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPC5"/>
    <dbReference type="STRING" id="49390.A0A068TPC5"/>
    <dbReference type="Gramene" id="CDO97784">
        <property type="protein sequence ID" value="CDO97784"/>
        <property type="gene ID" value="GSCOC_T00021687001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPC5"/>
    <dbReference type="OMA" id="SPVHPKY"/>
    <dbReference type="OrthoDB" id="737456at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35488:SF4">
        <property type="entry name" value="DUF4005 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35488">
        <property type="entry name" value="OS05G0358900 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="165" mass="18046" checksum="7F13640E5BA73EDC" modified="2014-10-01" version="1">MKTSPVFPSNEAGNYFGHEFDPHAEFALFLGEARKRTCDEGTFKFKVAPPDTEETRKTESNGEKRNKKSWKSSLFSWLKSDKKSDNLVEPLHGSAAPKLGRGIVSGPLRGSAGGLVPAKPRKPVSGPLMSLFNPADKVDGIPYMCLSHLTNPHEAQSYGPVYLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPG3</accession>
    <name>A0A068TPG3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00014503001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPG3"/>
    <dbReference type="FunCoup" id="A0A068TPG3">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPG3"/>
    <dbReference type="Gramene" id="CDO97233">
        <property type="protein sequence ID" value="CDO97233"/>
        <property type="gene ID" value="GSCOC_T00014503001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPG3"/>
    <dbReference type="OMA" id="YFETRCV"/>
    <dbReference type="OrthoDB" id="1852153at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPG3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31439">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31439:SF7">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO97233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="543" mass="60691" checksum="940EB20E01A915EC" modified="2014-10-01" version="1">MDIWSWICELPDSEDWFAESTSLSYQLTSSKPISNSTQTSIQLRAERTFEPNSEVSLTFSVVFQKYSDSTEAEASTATLCVSDKCHLAQDKPFLPLVLQLLQEIISRSPNAHDSTCPRSQLQKLKPEPIAWILDSHSPESFSSFFHLIFLARLFWICVFDAPSEVGSLYFHSLLAPNLGAFSCKQAPVLRTFFVSVGTDVELCLMRAFGYMLAKSLIFRQVGGLEAGLKALAPSASHRLGFSYATESHGLWILKGYTPVTAMDCATSNRNPNMHQFPVIEPKESALRYSLGHQQLEAVIQLEYKVEFCDAFIRVHALVDNIRLHVVKLGFKSKESGDDDDVLRNERHFPSRVRVWVGPEIGASYVGGLSLGRSTGNVEREVEIQKIFKGSSGKEITTPKVMGVARMATRTKMKNWRWDQDVEGNAGIFDGMLCDNTTGKEVATWKPSTGGRENDLAVNSFMRRNRAFTKSGGVVFAGEECCGGNGGVGWRLNKEMEGSVLKWRIGGQVWLTYWPNDVKSSYYETKCVEWCDEVDLPLIPGKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPL7</accession>
    <name>A0A068TPL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin alpha-6 chain</fullName>
        </recommendedName>
    </protein>
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            <taxon>Viridiplantae</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
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                <person name="Anthony F."/>
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                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
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                <person name="Dussert S."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">cv. DH200-94</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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            <begin position="161"/>
            <end position="191"/>
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        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    <sequence length="229" mass="25757" checksum="18B30671F4AB59EF" modified="2014-10-01" version="1">MATLHSISLKSSISPFSVSQSRQGFPCKWSFLCSELDSRNSGRKNFGSRSKKLSLRILIRRRLSVSCNVKESDNQSNGEEPPESLFMKELKRRGMTPASLLEEKTKSGYVGQETTSREEDGGFSRANAVSTNPERNLTNQREQSMALNSEGLEGLIPRARLLLTLGGTFFLGFWPLILITFAFFSTLYLYFGPNFVHDAGNTRVTPPEYIDPYQLLEEERISSTAPRLN</sequence>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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    </evidence>
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    <sequence length="153" mass="17262" checksum="874CDBB8BCC4A60E" modified="2014-10-01" version="1">MATFVGSASSSSSWIQMKNSAKKGKNNGKDNTKFRVSCVSSSIADPYKTLRIHPSASESEVRKAFRQLALQYHPDVCKGSNCGVQFHEINEAYDIVMSNLRGESTQSQMEAYDDGIDDSFRGMNDPDWDMWEEWMGWEGAGIRDYTSHINPYI</sequence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO98370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15660" checksum="BAB7B58B93C75F0A" modified="2014-10-01" version="1">MANKFPICSVCTSWVQEPKPEDHLGLPLEPSKPEHDYGMYKKLLHQYAQKSGFPLPVYKIENEGFPHAPKFRSSVFIDETKFTSKFTFPDRRAAEQDVAKLAYETIVKDNKTLTGGPHIYQVHQIFTWLHFIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ30</accession>
    <name>A0A068TQ30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00022418001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ30"/>
    <dbReference type="STRING" id="49390.A0A068TQ30"/>
    <dbReference type="Gramene" id="CDO98351">
        <property type="protein sequence ID" value="CDO98351"/>
        <property type="gene ID" value="GSCOC_T00022418001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ30"/>
    <dbReference type="OMA" id="KYCGDSE"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000005">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO98351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="446" mass="49848" checksum="E7C0A62F2F93ADA0" modified="2014-10-01" version="1">MREILHIQGGQCGNQIGSKFWEVVCDEHGIDPTGRCNGSSALQLDRVNVYFNEASGGRYVPRAVLMDLEPGTMDSIRTGPYGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFEVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLSTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQLINVQNKNSSYFVEWIPNNVKSSVCDIPPKGLTMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDATADEDAEYEDEEEAGAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR31</accession>
    <name>A0A068TR31_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GDSL esterase/lipase At4g16230-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00025668001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR31"/>
    <dbReference type="FunCoup" id="A0A068TR31">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TR31"/>
    <dbReference type="Gramene" id="CDO98755">
        <property type="protein sequence ID" value="CDO98755"/>
        <property type="gene ID" value="GSCOC_T00025668001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR31"/>
    <dbReference type="OMA" id="DVYHIFS"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR31"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051238">
        <property type="entry name" value="GDSL_esterase/lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650:SF4">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657252" description="GDSL esterase/lipase At4g16230-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO98755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40377" checksum="97A32C5F985D3C10" modified="2014-10-01" version="1">MDYLSYRKLAAGILFQLLALFVRLKTCFCEVAPPANFVFGDSLVDVGNNNYIVSLSKANFVPNGIDFGKPTGRYTNGRTIVDILGEEVGIKGFTPPFLAPTTAGPVVLQGVNYASGGGGILNHTGKIFVGRINFDAQLDNFANTKEYIISTIGAPMTMKLLQTALFSVTMGSNDFINNYLVPVVSKVQQNLVSPETFVADLITRYRTQLTRLYNMGARKIVVVNVGPIGCIPYQRAINPSSGKGCVAFPNRLAQLFNSQLRDLVTELRSNLKGSKLIYADAYRIVDDLIQNYFSYGFGNADSACCYVAGRFGGLIPCGPTSKICADRSKYVFWDPYHPTDAANSFIAKRLLDGGSGDVWPMNIRQLISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU36</accession>
    <name>A0A068TU36_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025809001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU36"/>
    <dbReference type="FunCoup" id="A0A068TU36">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU36"/>
    <dbReference type="MEROPS" id="C48.A02"/>
    <dbReference type="Gramene" id="CDO98863">
        <property type="protein sequence ID" value="CDO98863"/>
        <property type="gene ID" value="GSCOC_T00025809001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU36"/>
    <dbReference type="OMA" id="ANRWTIL"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU36"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000005">
        <property type="entry name" value="Ubiquitin-like-specific protease ESD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="309"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="511" mass="58581" checksum="28F0FB879707C2A9" modified="2014-10-01" version="1">MGALTSNRKRGYDFSSSVNYGSLVSNSPVSKKSRLPASINQTTGRTDRITAVFQFFRYPVEKTLFKREPHAPVRRHRGVSSVNLGNSASKVSYKVGSADEMGNLLSGQYKSTKRSALDTLRFNEEDKKVTEVAKEEVQEVSEDSSIEEVEILEVREDQKWKDGNGVVDEDSRKFDGIAVDKDSRPSSSSAMTNVSDGILKVETTEKLLESLSLSQELGVPQESVHKKLLYVAERRNDKINSLNFQIEYTEKQLQLQQLLRPQKKEEAAKKDVTAEAFKPLTEEEETEVNRALSNSSRRKLLVTHENSNISITGEVLQCLRPRAWLNDEVINLYLELLKERERREPKKFLNCHFFNTFFFKKLVSGKGGYNYQSVRRWTSQKKLGYCIFDCDKIFVPIHKEVHWCLAVINKKDEKFQYLDSLGGVDSQVIKVLARYIVDEVKDKCGKGIDVSSWQQEFVADLPEQENGFDCGVFMIKYADFYSRDIGLCFNQEHMPYFRLRTALEILRSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU92</accession>
    <name>A0A068TU92_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029158001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU92"/>
    <dbReference type="STRING" id="49390.A0A068TU92"/>
    <dbReference type="Gramene" id="CDO99534">
        <property type="protein sequence ID" value="CDO99534"/>
        <property type="gene ID" value="GSCOC_T00029158001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU92"/>
    <dbReference type="OMA" id="YNTAICK"/>
    <dbReference type="OrthoDB" id="691424at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU92"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006502">
        <property type="entry name" value="PDDEXK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31579:SF2">
        <property type="entry name" value="DUF506 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31579">
        <property type="entry name" value="OS03G0796600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04720">
        <property type="entry name" value="PDDEXK_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="169" mass="19088" checksum="1A5C2AFC769A7FE3" modified="2014-10-01" version="1">MARISRNHRILTWDNREIEHSGDPAIHIPDTVFRFLDEESEGSLVGSFSDNGEYEIQDDDNNEEKDVPANDRDKSFWESQNQLLQGTLCRTSSIESKIRTITKEAVKEVQQSGNLICNCGRATNADGCKNCLMKEVCRRLQSAGFNSAICKSKWRSSPDIPSALTLFCR</sequence>
</entry>
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    <accession>A0A068TVI1</accession>
    <name>A0A068TVI1_COFCA</name>
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    </protein>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
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</entry>
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    <accession>A0A068TW55</accession>
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        </submittedName>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
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                <person name="Pietrella M."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Rozas J."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
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                <person name="Graziosi G."/>
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                <person name="Giuliano G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="338" mass="36546" checksum="6258E81033CECE7D" modified="2014-10-01" version="1">MASSCSLQCGNDGQNCCQTCPEVSGAGPAAAAAADGCNKGFMLFGVRVMEGSFRKSASMNNLAQFEQPQDSMNNNDVNAGYASDDVVHPSARNRERKRGVPWTEDEHRLFLLGLQKVGKGDWRGISRNFVKTRTPTQVASHAQKYFLRRNNHSRRRRRSSLFDITTDTVLGSAMEDRAQEESVPQPAMQQQKNLINNLEKFPMSTYPTNIAPVMLPVNPVKGASSLESLTLGPANNQLLLNRTNNTSSPTPKLIRPIPLAPIPPSSKMADLNLNKTTIPDPLPLSLKLSTPSSSAASQPSSEQHSPSSSSPPARHTSPFQAMPSSFDNSSGDSIISVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWE7</accession>
    <name>A0A068TWE7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00032143001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWE7"/>
    <dbReference type="STRING" id="49390.A0A068TWE7"/>
    <dbReference type="Gramene" id="CDP00259">
        <property type="protein sequence ID" value="CDP00259"/>
        <property type="gene ID" value="GSCOC_T00032143001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWE7"/>
    <dbReference type="OMA" id="RTMSAKY"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWE7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990714">
        <property type="term" value="F:hydroxyproline O-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010405">
        <property type="term" value="P:arabinogalactan protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000005">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000071">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase GALT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF286">
        <property type="entry name" value="HYDROXYPROLINE O-GALACTOSYLTRANSFERASE GALT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="16">
        <location>
            <begin position="140"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP00259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="627" mass="72545" checksum="8D5F24ED76BC7A7A" modified="2014-10-01" version="1">MKRGKFDSLIPVSRIRSIQILMGFLFLYLVLMSLEIPLVLRNGLGLESPEPDSTISINTLPIRSPDASEYFVKENPVFNFQERKKEQFKKVSGLTFDEIAFDSVSKDDFSELHTTVRDAFVMGKKILEEIESGNVKAELQNRTQNRTESCPSSVSLSGVEMQKKGKLMIGLLREGDETLMVSQFMMELQGLRVVDGEDPPKILHFNPRIKGDWRGRPVIEQNTCYRMQWGSALRCEGWKSNADEETVDGQVKCEKWIRDDDDRTEESKATWWLKRLIGRTRKVTVDWPYPFVEGKLFVLTLSAGLEGYHINVDGRHITSFPYRPGFTLEDATGLYINGNIDVHSILAASLPTTHPSFAPQQHLEMLTKWQAPPLHDGPVELFIGILSAGNHFSERMAVRKSWMQYKSIKSSEYIARFFVAMHRRKEINVELMKEAEFFGDIVIVPYMDHYDLVVLKTIAICEYGVRTVAAKYIMKCDDDTFVRVDAVMKEVKKVHHGRSLYIGNINYYHIPLRHGKWAVTYEEWPEEEYPPYANGPGYVMSSDIANSIVTDFEKHRLRLFKMEDVSMGMWVERFNSSKQVEYVHSLKFCQFGCIDDYYTAHYQSPRQMICLWDKLQLKEKPRCCNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYM3</accession>
    <name>A0A068TYM3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034666001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYM3"/>
    <dbReference type="FunCoup" id="A0A068TYM3">
        <property type="interactions" value="1153"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYM3"/>
    <dbReference type="Gramene" id="CDP01137">
        <property type="protein sequence ID" value="CDP01137"/>
        <property type="gene ID" value="GSCOC_T00034666001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYM3"/>
    <dbReference type="OMA" id="IHLYRQG"/>
    <dbReference type="OrthoDB" id="658712at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYM3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35475">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35475:SF1">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="190" mass="21210" checksum="94153D8BAEBAB2A2" modified="2014-10-01" version="1">MGEIEEEAAPANADESSPLLSDPKSPHRIRSVRTKVPEVEVHLYKLGKGPIDVFKSSLSGWDQDQLEVRDILDKYGFKSVYAFTPGSCRGAPIRFNPRNGRSLLSYKDGSVVYLDGQPKDSLVKPVTKIVSGVAFITVLIVFAIKEAPPDWARKLNLSGGRIPPWILACAVIVFTRMRKRTRDFLEKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZZ6</accession>
    <name>A0A068TZZ6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF241 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036991001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZZ6"/>
    <dbReference type="STRING" id="49390.A0A068TZZ6"/>
    <dbReference type="Gramene" id="CDP01821">
        <property type="protein sequence ID" value="CDP01821"/>
        <property type="gene ID" value="GSCOC_T00036991001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZZ6"/>
    <dbReference type="OMA" id="DICEATR"/>
    <dbReference type="OrthoDB" id="1701699at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004320">
        <property type="entry name" value="BPS1_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070:SF109">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF241)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070">
        <property type="entry name" value="OS06G0725500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03087">
        <property type="entry name" value="BPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33078" checksum="FF2737170BA97822" modified="2014-10-01" version="1">MASKSTCHIRSISLPCRSHPTTLAVEEELNRFASWEASSTSEAICKDLCRLAELYKCMDDVLNLPLNIQSLSQHQKQKWGEQLLDNSVRILDICGITREIVSQFKENVKDLQSSLRRRKGDSSTETSVTKYSCFRKKMKKDAKRSIAALKQIDHEISASAIMDLDDQHISSVIRVLREVNTTSIAIFKNVLLFLTSQSPKAKPSKWSLVSRLVNKKKVGFEDQQEVENEFESVDSALHSLCRNDQSENEKIQSVQNRLETLEASIEGLENGLEGLFRCLIRSRTSLLNIISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0G2</accession>
    <name>A0A068U0G2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00036946001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0G2"/>
    <dbReference type="STRING" id="49390.A0A068U0G2"/>
    <dbReference type="Gramene" id="CDP01787">
        <property type="protein sequence ID" value="CDP01787"/>
        <property type="gene ID" value="GSCOC_T00036946001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0G2"/>
    <dbReference type="OrthoDB" id="505266at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0G2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF24">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="44" mass="5657" checksum="1D81BFF561F92E70" modified="2014-10-01" version="1">MIKKKLVKKQRQNRPIPYWIRMRTDNTIRYSAKRRHWRRTKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0H3</accession>
    <name>A0A068U0H3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">catalase</fullName>
            <ecNumber evidence="4">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00036968001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0H3"/>
    <dbReference type="STRING" id="49390.A0A068U0H3"/>
    <dbReference type="Gramene" id="CDP01802">
        <property type="protein sequence ID" value="CDP01802"/>
        <property type="gene ID" value="GSCOC_T00036968001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0H3"/>
    <dbReference type="OMA" id="THICKAK"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0H3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08154">
        <property type="entry name" value="catalase_clade_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000002">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF23">
        <property type="entry name" value="CATALASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="13"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP01802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="469" mass="54178" checksum="BB24A4CBADDFD3EE" modified="2014-10-01" version="1">MVILVDRTCSKDSIHSGAEIISFVANPIRYKINGYFYCASAKGVFEVTNDITQLTCADFLRTPGVQTPVIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNFPVFFIRDGMKFPDMVHSLKPNPKSHIQENWRIVDFFSHHPESLHMFTFLFDDIGVPQDYRHMDGSGVNTYTLINKAGKAHYVKFHWKPTCGVKSLLEEEAIKVGGANHSHATQDLYDSIAAGNYPEWKLFIQTIDPDYEDKYDFDPLDVTKTWPEDILPLQPVGRLVLNRNIDNFFNENEQLAFCPAIVVPGIHYSDDKLLQTRIFSYADTQRHRLGPNYLQLPANAPKCAHHNNHHDGFMNFMHRDEEHCTFCPCVDYFPSRYDPVRHAEMHPIPSAVLTGRREKTIIPKENNFKQPGERYRSFAPDRQERFICRWVDALSDPRVTYEIRSIWISYWSQADKSLGQKLASRLNIRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0T5</accession>
    <name>A0A068U0T5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00037139001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CPYC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0T5"/>
    <dbReference type="FunCoup" id="A0A068U0T5">
        <property type="interactions" value="1173"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0T5"/>
    <dbReference type="Gramene" id="CDP01947">
        <property type="protein sequence ID" value="CDP01947"/>
        <property type="gene ID" value="GSCOC_T00037139001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0T5"/>
    <dbReference type="OMA" id="YACYELD"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0T5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF4">
        <property type="entry name" value="GLUTAREDOXIN-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15066" checksum="6CE2ABAAA7DE792A" modified="2014-10-01" version="1">MLMTTWNNRRLLVTVTTIGVLWSTLIAAPRKTIAANSPSAFVQNAIYSNKIIIFSKSYCPYSLRAKHIFSELHEQPFVVELDLRDDGYQIQNILLDLVGRRTVPQIFVNGKHVGGCDDLQAAVRDGQLHSLLGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1L6</accession>
    <name>A0A068U1L6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00036577001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1L6"/>
    <dbReference type="FunCoup" id="A0A068U1L6">
        <property type="interactions" value="2813"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1L6"/>
    <dbReference type="Gramene" id="CDP01503">
        <property type="protein sequence ID" value="CDP01503"/>
        <property type="gene ID" value="GSCOC_T00036577001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1L6"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="2015843at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1L6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP01503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="249" mass="28401" checksum="0FAFC4EDF2BA85C3" modified="2014-10-01" version="1">MKFNIANPTTGCQKKLEIDDDQKLRIFWDKRISQEVSGDALGDEFKGYVFKIMGGCDKQGFPMKQGVLTPGRVRLLLHRGTPCFRGYGRRNGERRRKSVRGCIVSPDLSVLNLVIVKKGENDLPGLTDIEKPRMRGPKRASKIRKLFNLSKEDDVRKYVNTYRRTFTTKAGKKVSKAPKIQRLVTPLTLQRKRARIAQKKMRIAKAKSEAAEYQKLLATRLKEQRERRSESLAKKRSRLSAASKPSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1V3</accession>
    <name>A0A068U1V3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00039437001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1V3"/>
    <dbReference type="STRING" id="49390.A0A068U1V3"/>
    <dbReference type="Gramene" id="CDP02139">
        <property type="protein sequence ID" value="CDP02139"/>
        <property type="gene ID" value="GSCOC_T00039437001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1V3"/>
    <dbReference type="OMA" id="YASEERM"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1V3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF79">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657273" description="Protein kinase domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="352"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP02139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="640" mass="70676" checksum="F32B74CBBEDED6D0" modified="2014-10-01" version="1">MNKIFIWVFLFSFFLHFHSIKPDEEELRAALSNLITGLTESAPPNQASPWNLTSYPCRDHWDGVACDNRNSLRNITLDGLKLSGNLNASFLCDVQSIAASLTVMSLKDNNLQGESLAEIANCRQLTRLYLGGNRFNGSLPDSFLRLNNLKVLDISSNNFSGTLPDLSRISGLTEFSAQNNQLSGFLPSFEFSNFHTFNVSNNNFSGPIPSGGDRFPASSFTKNDQLCGPPLPNSCPSASSDSSDKPKGGYSKDEILTFLGYFLLGLTVLLATIVFLCRRCKKAEAKVEADSRVASVDDSISKQIYAPSNFKTGPVSKSDYSTASGESAVVPSSLIVLSSPEVSGIRFENLLKAPAELLGRGKHGSVYKVFSEEMGMILAVKRIKDWTISSYDFKQRMRRLDRVKHPNILPALAFYSSNQEKLLVYEYLQHGSLFNLLHGTQMGRTFDWSTRLDVAASIADGLAFMHQELREDGIAHGNLKSSDVLLTQNMEPYISEYGLVLDSQDPSLAGSDNSYQGNGEHLNRAIFRADVYAFGVILLELLTGKLVQSDGLDLASWVVSVVREEWTVEVFDRTLIREGASEVRMVNLLQIAIKCVNRSQEARPSMNEIAAMISTLKEEEDKSMDDASALISTSIYERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U257</accession>
    <name>A0A068U257_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00040048001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Gramene" id="CDP02606">
        <property type="protein sequence ID" value="CDP02606"/>
        <property type="gene ID" value="GSCOC_T00040048001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U257"/>
    <dbReference type="OMA" id="CWFLTGF"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
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            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55624" checksum="15BD8E4433EC713A" modified="2014-10-01" version="1">MPKSNRIVTPLLFFLISTTFTYNCLVFASPVPEQSLKRPDPLRHFKPYNGVYDIRNRHYWASAAFTGIHGYAVAGIWFLFGLGFGSYLILKNLFGSCFRIVNYPHSFYIATFSLVVLFTLLAIIASSFVFAASKSSQKRANRLVDTVFGAASDASGAMRRVINSLVDMQALLRPYDPQTCNLLNVTSHRLRRESLLIKDFVAKTKHPSHEAVEILYSTTVAVVTINLMLLVAALVLLILHWYPGIMVIIFCCWILTTLSWILTGFDYFFQTFARDTCSALVKFEENPDDSSLRFIHPCASPSDSNNLLVQIGKTVHNFISQANTKLTELKAVLGIQEGNEDTLGFQEICDPFASAPNYVYAPQNCHKDAIPIGDLPNILSRFTCYKGNSSEECLVDGRFLPEASYVMAEAYSHSIQDLINVFPDLLSLTQCTSVKQAFSDIVVRQCKPFKTSVRMLWSSALSLSLIMTVLVSLWVAKTCRDRHRSFAKFSIVPKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U327</accession>
    <name>A0A068U327_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00040137001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068U327"/>
    <dbReference type="STRING" id="49390.A0A068U327"/>
    <dbReference type="Gramene" id="CDP02672">
        <property type="protein sequence ID" value="CDP02672"/>
        <property type="gene ID" value="GSCOC_T00040137001"/>
    </dbReference>
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    <dbReference type="OMA" id="FQGFNVN"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057427">
        <property type="entry name" value="WAV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF59">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE EDA40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25243">
        <property type="entry name" value="WAV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="349"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP02672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="82950" checksum="0305F08789725A47" modified="2014-10-01" version="1">MVLGWRKAFCTSISRDRDSSIHSSSSTSNGGRQDKISHDAHQSNPTTPKLSSKLSFFSIPSTPRLQSQPVSSPRLRCRTTPTTRATSTPSTPPLQPPESPKRQCKTAKNSPRFFQLRSSTPSSPRSPSTLSLLKSTLRISSKTRCGICLHSIKSGQGMAIFTAECSHSFHFPCVAGHVRKQGTLACPVCNSTWTEMPLLSIHNVSGSSSSHHSRLDKQEKRMEFPSSPKTPPPPPPSSNSCKQPVLKVYNDDEPLMSPTCGARFNPIPESDENGEEDSDNITEEFQGFYPTTTNPFQKSTASALGNVETKISPEAAVISIGRSSQTFVVVLKIRAPPAPTNAARRAPIDLVMVLDVSRKLTNEKLQMMKRALRLVVSSLSPADRLSIVAFSSTSKRLLPLRRMTAAGRRSARRIVDSIVSLDGTAPASANDAIKKAAKVLEDRREKNPVASIILLSDAIEDRSANQRRQSSVVCTTRVTHYEVPVLSVGLRHCGAYGHGAPPDDSLAKCVGGLLSVVVQDLRVHLGFISGSGHGQVAGVYSFGGRAMALGSGLVRLGELFAEEERELLVELKVPSMSSAGAHHALSVRCSYKDPSTQVLIQGKEQALLVPRPQALRSSTPSGIERLRSLFVATRAVAESRRLVERNDLAGAHQLLTSARSLVLQASSSSEWGEEYVSGLEAELSELHWRRQNQVQQIPGRRNVERRHPTGASSGGSIRLDEKSSEPLTPTSAWRAAERLAKVAIMRKSMNRVSDLHGFENARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4R3</accession>
    <name>A0A068U4R3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00015902001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4R3"/>
    <dbReference type="FunCoup" id="A0A068U4R3">
        <property type="interactions" value="2042"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4R3"/>
    <dbReference type="Gramene" id="CDP03506">
        <property type="protein sequence ID" value="CDP03506"/>
        <property type="gene ID" value="GSCOC_T00015902001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4R3"/>
    <dbReference type="OMA" id="NCASKIG"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4R3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000416">
        <property type="entry name" value="p-loop nucleoside triphosphate hydrolase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056653">
        <property type="entry name" value="DUF7751"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF73">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24933">
        <property type="entry name" value="DUF7751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137107" checksum="E2B6573E38DF5590" modified="2014-10-01" version="1">MVETRRSSSTSKRPLPSPSSPLPKGKRSKAGEASSSTNDSSGEVGIDAAKESGRESREQEVRSADLTDADNLKLSDGEVPEKLPEGQLESEPLVSPMTLGDSVIDLEKTKSIGKVLNRGKKRQMKSKAAAAWGKLLSQFSQNRHVVISNSTFTVGQDRQSDLWVGDPSVSKSLCRLRHISTERGCPVTLLEITGKKGSVQVNGKIYPKNSTVPLSGGDEVVFSSSGKHAYIFQQLTPDNVSGTALPPSVNILESHNGPIKGLHFEARSGDSSAVAVASTLASLSNLRKELSLLPPSSRKDEDVQEGSEMPTLPSTCEVSDNPIVDAEMKDTTDHNDSPVLGEKANVPLSRAANENMNLDSVEIDPVDPEIGKEAAASHDIRFLRMFPRSGAAEFDLSGSISKILDEQREIGELLKDLDPPILTSTRREAFKDVLQQGVIDPNCIEVSFENFPYYLSETTKNVLIASTYIPLKCNKFAKFTSDLPTVCPRILLSGPAGSDIYQEMLTKALAKHFNAKLLIVDSLLLPGGSTVKEVDSVKEGSRPERASVFAKRAAHTAALHLKKPASSVEAEITGGSTLSSQAQPKQESSTASSKTYTFKKGDRVKYMGPLSSGFSPMQTPSRGPSYGYRGKVVLAFEENGASKIGVRFDRSIPEGNDLGGLCEDDHGFFCAADLLRLDTSTDDFDRLAIHELFEVASKESKNSPLILFVKETEKSMMGNPEAYASFKVKLEKLPKNVVVIASHTQTDNRKEKSHPGGLLFTKFGSNQTALLDLAFPDNFGRLHDRGKETPKTMKQLSRLFPNKVTIQIPQDESMLSDWKQQLDRDIETLKSQSNIVSIRTVLNRVGIDCPDLDSLCIKDQALTSENVEKIIGWALSHHFMHFSEASVKDSRLSIANESISYGLNILQGIQNETKCSKKSLKDVVTENEFEKRLLADVIPPTDIGVTFDDIGALENVKDTLKELVMLPLQRPELFCKGQLTKPCKGILLFGPPGTGKTMLAKAVATEAGANFINISMSSITSKWFGEGEKYVKAVFTLASKIAPSVVFVDEVDSMLGRRENPGEHEAMRKMKNEFMVNWDGLRTKDKERVLVLAATNRPFDLDEAVIRRLPRRLMVNLPDAPNREKILKVILSKEEVAPNVDLESIANMTEGYSGSDLKNLCVTAAHCPIREILEKEKKEKALALRENRPLPALHTSSDVRPVSMEDFKYAHEQVCASVSSESANMNELLQWNELYGEGGSRKKKSLSYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4U6</accession>
    <name>A0A068U4U6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00040079001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4U6"/>
    <dbReference type="FunCoup" id="A0A068U4U6">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP02628">
        <property type="protein sequence ID" value="CDP02628"/>
        <property type="gene ID" value="GSCOC_T00040079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4U6"/>
    <dbReference type="OMA" id="VGNREIM"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4U6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF21">
        <property type="entry name" value="OS03G0770000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="234" mass="26630" checksum="1120FBC1FFB659B2" modified="2014-10-01" version="1">MLSADCLFGNPFPAFESGFPPWDCQEPPFVFPQHDDPILSPLGELRVETQEPVISNSGSETYTPPPLDPTGQAISISGSENYDPTPLDSSSGSEEPNQNNKRPYPGSDDTTNPPVDSAADERKRRRMLSNRESAKRSRMRKQKHLENLRNQVSRLRIGNRELVNRLRVVTHHCQLVRTDNDRLRSESVILRQRLWDIRQVLLVRQLQQQLATSAWPCNNLTPMNDETIPQPLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5J9</accession>
    <name>A0A068U5J9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016216001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5J9"/>
    <dbReference type="Gramene" id="CDP03741">
        <property type="protein sequence ID" value="CDP03741"/>
        <property type="gene ID" value="GSCOC_T00016216001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5J9"/>
    <dbReference type="OMA" id="MSCLRLR"/>
    <dbReference type="OrthoDB" id="1536762at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5J9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008480">
        <property type="entry name" value="DUF761_pln"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05553">
        <property type="entry name" value="DUF761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="237" mass="27189" checksum="D6B1FD1E7EE996C9" modified="2014-10-01" version="1">MPTHAAGFSKYKRKPTPDTGIPSHPVHHLLAVSMSCLSFNKLLPSRKAWRVFTEKVQTKLHKLHPSKTIKKPKNRLKKTGKKTSCWPAFCTQSKVQRKRFKHKPSQTQTLRSYYVHKRPSAVYIDRLFIEPAAVSLVRVHSQPPKKAAATTASKEYQEVCPSTLNTEKPELVDQRENTAGTSKEEEKLNENMHSADDMWESLVLASPQMNGINERAEEFITRFRAEMLLQEQLAHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5S0</accession>
    <name>A0A068U5S0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="9">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00041402001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
            <location evidence="9">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
            <location evidence="9">Extracellular space</location>
            <location evidence="9">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="9"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5S0"/>
    <dbReference type="STRING" id="49390.A0A068U5S0"/>
    <dbReference type="Gramene" id="CDP02963">
        <property type="protein sequence ID" value="CDP02963"/>
        <property type="gene ID" value="GSCOC_T00041402001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5S0"/>
    <dbReference type="OMA" id="KMQPMRL"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5S0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0052">Apoplast</keyword>
    <keyword evidence="9" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103889" description="Xyloglucan endotransglucosylase/hydrolase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP02963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="290" mass="32553" checksum="A88B5E7C61FD94EE" modified="2014-10-01" version="1">MASLSLINVPFLLVISLSIVTSSMVASANNFYQDFDITWGGSRGKILDNGELLTLSLDNISGSGFQSKKEYLFGKIDMQLKLVPGNSAGTVTAYYLSSIGPIHDEIDFEFLGNLSGQPYILHTNVYTQGKGEREQQFYLWFEPTADFHTYSVHWNPSAVVFSVDTIPIRVFKNLESIGVAFPKTQPMRLYSSLWNADEWATRGGLVKIDWTQAPFMASYRGFSSSACSLASAKPSCVSSMPNYSPWLSEQLDPLGERRLRWVEKNYMIYNYCTDAKRFPQGFPPECRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6X7</accession>
    <name>A0A068U6X7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOD1/MUCI70 glycosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017555001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6X7"/>
    <dbReference type="FunCoup" id="A0A068U6X7">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6X7"/>
    <dbReference type="Gramene" id="CDP04231">
        <property type="protein sequence ID" value="CDP04231"/>
        <property type="gene ID" value="GSCOC_T00017555001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6X7"/>
    <dbReference type="OMA" id="YWTVLKE"/>
    <dbReference type="OrthoDB" id="1905162at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6X7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090406">
        <property type="term" value="C:pollen tube"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009992">
        <property type="term" value="P:intracellular water homeostasis"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:1902456">
        <property type="term" value="P:regulation of stomatal opening"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TOD1_MUCI70"/>
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        <property type="entry name" value="TOD1_MUCI70_glycTrfase_dom"/>
    </dbReference>
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        <property type="entry name" value="ALKALINE CERAMIDASE TOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12956">
        <property type="entry name" value="ALKALINE CERAMIDASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04765">
        <property type="entry name" value="TOD1_MUCI70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="TOD1/MUCI70 glycosyltransferase-like" evidence="2">
        <location>
            <begin position="114"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="453" mass="52033" checksum="A6806DAB14CBA114" modified="2014-10-01" version="1">MAAVVSLKTSKPLLFQSKLLCFSLFYFFSSLFLALYTTLSNTKCLFRSSPFDPIQYSLFSYPSSYGEHKYAIPTLRSSCDSPVYFSDYAAVSQEIQDLCRNSTALGSRTLNYMQRNAQSFGGNFSTQKRFSFFDHPRDGAEIPCGFFQGIPITFHDRAIMDRCDRVVVVSAIFGDHDKIRQPRGLGAKTLDSVCFFMFVDEVTLDRLDYHNLISRKVKEPKVGVWRIVKVASEKLYESAAMNGVIFKYLVHRLFPNSKYSIWIDAKLQLVIDPLLLVHSLVIQEDADMAISKHPFFLHTMEEAMATARWKKWWDVDGLKSQMETYCENGLEPWSPNKPYPSDVPDTALIIRKHSMATNLFSCLVFNELEAFNPRDQLAFAYVRDHMNPTLKMNMFDVEVFEQVAIEYRHNLKQGGPSVPKGPKINRASFDLFVNKTCSKCEQYLLKMWGESHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U710</accession>
    <name>A0A068U710_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00017606001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP04271">
        <property type="protein sequence ID" value="CDP04271"/>
        <property type="gene ID" value="GSCOC_T00017606001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U710"/>
    <dbReference type="OMA" id="RKSVCHN"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U710"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010087">
        <property type="term" value="P:phloem or xylem histogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000297">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase PXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000410">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase PXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000412">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase PXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000470">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase RPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000400">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000444">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF131">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE BAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="665"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP04271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="973" mass="106577" checksum="DC689C5E7067BC76" modified="2014-10-01" version="1">MDHLKDWKVPSNEVEGSSIHCSWDGVWCNSKGFVESLDISNLNLSGQISEGIQGLSSLSFLNISCNDFSSALPQSLGSLASLKILDVSQNNFVGKFPVGFGNASGLKAINASSNNFVGLLPEDLSNATSLEILDFRGSFFEGSIPVSYKNLQKLKFLGLSGNNLTGKIPAEIGQLSSLETIIIGYNLFEGTIPAEFGNLTNLQYLDLAVGTLSGQIPAELGKLKKLTTVYLYHNNFEGKIPPEIGNLSSLVYLDLSDNDISGEIPGKIADLKNLQLLNLMCNQLTGPIPDKFGELTKLEVLELWQNTLTGRLPVNLGRNSPLHRLDVSSNSLSGEIPAGLCDSGNLTKLILFNNTFSGLIPVGLSNCSSLVRVRIQNNHLSGTIPPGLGNLPKLQRLELAHNNLTGAIPEDFTLSTSLSFVDASWNQLESSLPSSILSIPQLQTFAASNNKLEGNIPDQFQDCPSLSVLDLSSNHFSGKIPQSIASCEKLVNLNLRNNQFTGEIPRPIASMPTLSVLDLSNNSLVGQIPASFGSSPALEMLNLSYNKLEGPVPNNGILVTINPNDLIGNAGLCGGVLPPCSHKSNSILHFRKFHINHVFIGFFTGIAILIAIVVMVLVGRRLYKRWYLYRSFFKDWFKRDSTEWPWRLVAFQRLNFSSNDILASLKDSNVIGVGGTGIVYKAEVQRPHSVVAVKKLWRTESDLETGDDLFVEVNLLGKLRHRNIVRLLGYLHNENDVMMVYEYMPNGSLGAALHGKQAGKMLVDWVSRYSIALGVAHGLAYLHHDCHPPVIHRDIKSNNILLDSNFEARIADFGLARTMSHKNETVSMVAGSYGYIAPEYGYTLKVDEKSDIYSYGVVLLELLTGKTPLDPAFGEAIDIVEWVRRKVNNKTSESALDPDVAGQCKHVQEEMLLVLKIALLCTAKLPKERPSMRDIITMLGEAKPRRKSVCQNWGYTANKDKIIFAHSPVVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U788</accession>
    <name>A0A068U788_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015267001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U788"/>
    <dbReference type="FunCoup" id="A0A068U788">
        <property type="interactions" value="2056"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U788"/>
    <dbReference type="Gramene" id="CDP03478">
        <property type="protein sequence ID" value="CDP03478"/>
        <property type="gene ID" value="GSCOC_T00015267001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U788"/>
    <dbReference type="OMA" id="YVHDKDC"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U788"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47463">
        <property type="entry name" value="F-BOX PROTEIN SKIP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47463:SF2">
        <property type="entry name" value="F-BOX PROTEIN SKIP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="ApaG" evidence="3">
        <location>
            <begin position="304"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="445" mass="50048" checksum="D6260B07A1701234" modified="2014-10-01" version="1">MATLESVGGLAMHVILSKLAPNDAASVACVSRRFRTWASDDDSLWSKFCSDDFQLNSPLDPVGNPTATFKEAYGTWRDAFHMYPWPLVMRVKRCWDRLKNWFAANFPEILATLRRGASEEEINALEMSLKVKLPLPTRVLYRFCDGQDLNADNLTGRVPQSLLGLIGGYSFYDHQVNVFLLPLEQIVEETKDYIQQLLLNGRPKYIVVAASCTYREKTFFLNCRSGQLHVGTRNLLTDGEMIPCVPGSLISLLNDRKGSQVQDALLLWLEEHCRRLESGIIKVRQDDELRGINLFPELPPLCCTAITNGVKVRASAVFVPEGSNLEDEDEKYLFAYTVRMSLSPEGCIISGMNFGSCQLYWRHWVIRIGDAVVDNVNGEAVIGKFPLLRPGEEEFIYESCTFLSSLPGSIEGCFTFVPGRLTDPSSSPFEAQVARFPLLLPDYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7L4</accession>
    <name>A0A068U7L4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="4 13">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00017975001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Photorespiratory enzyme that dephosphorylates the 2-phosphoglycolate produced by the RuBisCO oxygenation reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="4 13"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7L4"/>
    <dbReference type="FunCoup" id="A0A068U7L4">
        <property type="interactions" value="1749"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7L4"/>
    <dbReference type="Gramene" id="CDP04545">
        <property type="protein sequence ID" value="CDP04545"/>
        <property type="gene ID" value="GSCOC_T00017975001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7L4"/>
    <dbReference type="OMA" id="AGLDFHI"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7L4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07510">
        <property type="entry name" value="HAD_Pase_UmpH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000447">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF75">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01139">
        <property type="entry name" value="C2.A:_Pyridoxal_Phosphate_Phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00039">
        <property type="entry name" value="phosphoglycolate_phosphatase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP04545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="314" mass="34388" checksum="CE2C3C0E1086064A" modified="2014-10-01" version="1">MEGGEGPETASAAAECGHQPLTPNDVKDLLHSVDAFLFDCDGVIWRGDVLIDGVRDTLDMLRSMGKKLVFVTNNSTKSRRQYAKKFHSLGITVTEDEIFSSSFAAAMFLKVNDFPKEKKVYVIGGEGILDELELAGFVGLGGPEDGKKTVELEANCLFEHDKSVGAVVVGLDPYINYYKLQYGTLCIRENPGCLFIATNRDAVGHMTDLQEWPGAGCMVAAICGSTQREPIVVGKPSTFMMKFLLKKFNVSTSRMCMVGDRLDTDILFGQNAGCRTLLVLSGVTNLSTLEDSSNHIRPDYYTSKLSDIKKLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7N8</accession>
    <name>A0A068U7N8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00017484001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Complex I is composed of at least 49 different subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7N8"/>
    <dbReference type="FunCoup" id="A0A068U7N8">
        <property type="interactions" value="2091"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7N8"/>
    <dbReference type="Gramene" id="CDP04174">
        <property type="protein sequence ID" value="CDP04174"/>
        <property type="gene ID" value="GSCOC_T00017484001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7N8"/>
    <dbReference type="OMA" id="EYILPYK"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7N8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF71">
        <property type="entry name" value="ACYL CARRIER PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP04174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="14763" checksum="387E07A88E359561" modified="2014-10-01" version="1">MAARNALLKYLRVNVHPVQPFLQNPRTVIGGSISNFLRHRCFSEEVRGSFLDKSEVTDRVVTVVKNFQKVDPSKVTPSAHFHNDLGLDSLDTVEIVMALEEEFGFEIPDNEADKISSINLAVDFIASHPQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U808</accession>
    <name>A0A068U808_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00018689001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U808"/>
    <dbReference type="FunCoup" id="A0A068U808">
        <property type="interactions" value="1085"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U808"/>
    <dbReference type="Gramene" id="CDP04656">
        <property type="protein sequence ID" value="CDP04656"/>
        <property type="gene ID" value="GSCOC_T00018689001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U808"/>
    <dbReference type="OMA" id="AFKSKQH"/>
    <dbReference type="OrthoDB" id="775087at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U808"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35770">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35770:SF1">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="256" mass="28205" checksum="30E25AAF5B77A619" modified="2014-10-01" version="1">MGFEEMEPVFGQLKAEWCSAPQQTTPLEPFLFLAGPLPNNPSTLRIHVSDFHSNTWAAVKSHSQLEDMRDSIGIGGSWSEFVEYVVASIKSDDVKLVMEGESKSGGAAYAKLIAQKAKGMPRISVSLVKLVDVNASEAMANLSLELYKAYKNMHISLIKEETRCCQLTNRIAAEQAKSETLQKQLNSMLFSKKQKLQKMNDDTTSDVVLVTPSQDSPDKQAAQISASTKATTRVVPAYRRAKVRGVFLQDSDDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U882</accession>
    <name>A0A068U882_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017788001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U882"/>
    <dbReference type="Gramene" id="CDP04409">
        <property type="protein sequence ID" value="CDP04409"/>
        <property type="gene ID" value="GSCOC_T00017788001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U882"/>
    <dbReference type="OMA" id="FTCFFSG"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="6885" checksum="15C4AD94CEE7765D" modified="2014-10-01" version="1">MAFLSSFVACFSYSRRVGCEGEDGSSQNKSSKVQKSGSEKMKKKSDAAPIPLSYFPVGSRSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U898</accession>
    <name>A0A068U898_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00018851001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U898"/>
    <dbReference type="Gramene" id="CDP04760">
        <property type="protein sequence ID" value="CDP04760"/>
        <property type="gene ID" value="GSCOC_T00018851001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U898"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8853" checksum="5AEB176330430255" modified="2014-10-01" version="1">MADAPNNVRISVDLEDMMISFFFFESKIRFFFLELRPDLEERKQGDKKQSALENTGKLMAFFFFFSEFNFCSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8A2</accession>
    <name>A0A068U8A2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">U-box domain-containing protein</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase PUB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00018735001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8A2"/>
    <dbReference type="STRING" id="49390.A0A068U8A2"/>
    <dbReference type="Gramene" id="CDP04681">
        <property type="protein sequence ID" value="CDP04681"/>
        <property type="gene ID" value="GSCOC_T00018735001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8A2"/>
    <dbReference type="OMA" id="GRACMVQ"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8A2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000442">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058678">
        <property type="entry name" value="ARM_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045185">
        <property type="entry name" value="PUB22/23/24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22849:SF103">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22849">
        <property type="entry name" value="WDSAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25598">
        <property type="entry name" value="ARM_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP04681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="398" mass="44558" checksum="99BBCE4C50EB13FE" modified="2014-10-01" version="1">MAIPPLFKCPISLDLFTDPVTLCTGQTYDRSSIEKWLAAGNLTCPVTMQKLDDLSMVPNHTLRHLIDQWLQEDSQFCLDYREMINHVDCISVLKHRLDSEDSTLEEKLEIVEKVYILSEELPLQNSCLIQLDIFPLLLEKIFRKVNGSCSEDDLRFSERALACALKLLPFSDLTSLNMLKEEPVLDCFLSLFYRGNVNIKRNLCHIVEVISSSMETQQVSIMLGKSTKLQQELLNLLAETSEASEAGIKAISALSCLETSRENLVREGAVERLIAYILESEKYQRKLAPTAIATIERLLVVESAKEVVISNPSCVRALVKMVFRVSDHQGSESAVNSLLALCCDSNHAREEAISAGVLTQLLLLLQSQCSGRTKAKARMLLKLLNSTWVEQPKEAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U934</accession>
    <name>A0A068U934_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00017430001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068U934">
        <property type="interactions" value="1863"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U934"/>
    <dbReference type="Gramene" id="CDP04128">
        <property type="protein sequence ID" value="CDP04128"/>
        <property type="gene ID" value="GSCOC_T00017430001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U934"/>
    <dbReference type="OMA" id="MMDNLFL"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U934"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000006">
        <property type="entry name" value="HOPM interactor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF312">
        <property type="entry name" value="BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="587"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1426"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP04128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1788" mass="197512" checksum="AE3737DCF46A0BAF" modified="2014-10-01" version="1">MAGAAGGFVTRAFDSMLKECANKKYTALQTAIQSYLENAKHSNQQSSSSATMQTASSLGDESLTDTQAGSAKDTTEPDDSTTPSQCSVAADPIGRPKSAGGTITVTLANAGNTLGGDDAELVLNPLRLAFETKNAKVVELALDCLHKLIAYDHLEGDPGLDGGINGPLFTDILNMVCSCVDNSSPDSTTLQVLKVLLTAVASAKFRVHGESLLGVIRVCYNIALNSKSPINQATAKAMLTQMLSIVFRRMENDQVPTSSVSVAHKEAAAKSESNLGNEPASSNDQNDRESTLGDAISINQEKDTSVASLEELQNLAGGADIKGLEAALEKAVHLEDGEKATKGIDLEGMSIGEHDALLLFRTLCKMGMKEDNDEVTTKTRILSLELLQGLLEGVSVSFTKNFHFIDSVKAYLSYALLRASVSRTTSIFQYATGIFSVLLSRFRESLKGEIGVFFPLIVLRPLDGSDLNQKQSVLRMLEKVCKDSQMLVDLFVNYDCDLEAPNLFERMATTLSRIAQGTQNMDPNSITASQMGSIKTSSLQCLVNVIKSLVNWEKAQRESGKLKESSEVENSAKESDDSKGREDQASNFEKLKAHKSTLEAAVAEFNRKQEKGIEFLISSGLVESTPASVAQFLRNTANLDKVKIGDYIGQHEEFPLAVMHAYVDSMNFSGMKFDAAIREFLRGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNSLVWPKMSKSDFLRMNALHDAEESAPTELLEEIYDSIVKEEIKMKDEPVGIAKSSKQKPEAEERGRIVSILNLALPKGKSSGDSQSESEAIVKQTQAFFRSQGRKRGAFYTSHQIELVRPMVEAVGWPLLATFAVTMEEGDNKPRVVLCMEGFKAGIHITHVLGMDTMRYAFLTSLIRFNFLHAPKEMRSKNVEALRTLITLCDTDTNALQESWLAVLECISRLDYLTSNPTAAATVMQGSNQISRDAILQSLRELAGKPAEQVFVNSVKLPSESVVEFFTGLCSVSAEELRQIPARVFSLQKLVEISYYNMARIRMVWARIWSVLASHFIYAGSHPDERVAMYAIDSLRQLGMKYLERAELANFTFQNDILKPFVILMRNSRSDSIRRLIVDCIVQMIKSKVGSIKSGWRSVFMIFTAAADDDLELIVESAFENVEQVVLEHFDQVVGDCFMDCVNCLIGFANNKTSHRISLKAIALLRICEDRLAEGLIPGGALKPIDINAETTYDVTEHYWFPMLAGLSDLTSDPRPEVRNCALEVLFDLLNERGSKFTSSFWENIFHRVLFPIFDHVRQAGKENSVSAGDEWFRESSIHSLQLLCNLFNTFYKEVCFMLPPLLSLLLDCAKKTDQSVVSLSLGALVHLIEVGGHQFSDRDWDTLLKSIRDAIYTTQPLELLNDMGLENSRHHTALTRNLEVISGDTPTTPSANNGPLDNHQQNGSDSGNTYSMVSTNAGDDYEGSEGVPSPSGGAQKSIDAGGLQRSQTFGQKFMGNMRDSLFLRSFTTKSRNPSSDVFIPSSPSKLSDIVEPDAKNEEESSLLGTIRSKCITQLLLLGAIDSIQTKYWNNLTTSQKISIMDILFSLLEFAASYNSYTNLRLRMQQIPAERPPMNLLRQELAGTCVYLDILQKTTAEVNGNIEEAHKKSINENGDNHLVTTGATTTEQIKDEKLQGIAEEKLVSFCRQVLMEASDFQSTMGETANMDIHRVLELRSPIVVKVLNGMCSMNSKIFRNNLREFYPLITKLVCCDQMDVRGALADLCSKQLTELLPKAQQPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9A4</accession>
    <name>A0A068U9A4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019647001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9A4"/>
    <dbReference type="FunCoup" id="A0A068U9A4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9A4"/>
    <dbReference type="Gramene" id="CDP04867">
        <property type="protein sequence ID" value="CDP04867"/>
        <property type="gene ID" value="GSCOC_T00019647001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9A4"/>
    <dbReference type="OMA" id="IQWAMDA"/>
    <dbReference type="OrthoDB" id="1935019at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9A4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="21634" checksum="6B0FB7E3CEFB878B" modified="2014-10-01" version="1">MSSSNYDGRKKMEKSVEEDEVEELLKAAQDDMLLKLGLNSHMTHSSSQFSSIDPDLDSRFLALKKPHQSKSNSKSISKSKLDDTAGTTQKNPEKVLQNIDESDDLFARFAALKSSLPSYNTSVRDGQVQQQQQLMDDDGAGEEDEVEKVIKWAIDAARLDPSPPSNSNDDAASDADDVSDDEVDDGHGVDAGKKSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAI3</accession>
    <name>A0A068UAI3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00020698001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAI3"/>
    <dbReference type="STRING" id="49390.A0A068UAI3"/>
    <dbReference type="Gramene" id="CDP05575">
        <property type="protein sequence ID" value="CDP05575"/>
        <property type="gene ID" value="GSCOC_T00020698001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAI3"/>
    <dbReference type="OMA" id="YWSVEEL"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAI3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654726" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP05575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="613" mass="68656" checksum="092B99145F88BDC4" modified="2014-10-01" version="1">MEHHILCTFSSFLLLFLFSSIPITSQFPFGSSKQAYDHSNVTCIESERRALLQLKHELKDESNRLLSWIGEGCCSWEGISCHKITGSVLKLDLCNKVAFSDDFHCKNCLGGHLSPSLVNLTNLQYLDLSWNNFSGIQVPAFFGLLKNLRYLNLSRAGFDGEIPHHLGNLSHLRYLDLGDLGLNGLRTKDLGWSINMLPSLTTLDLRGCGLFIHPHLSHVNFTSLAFLDLRENNFNNYMVPHWLRNLTGLHDLRLGDNNLSNPIRGLFDQMTSLVHFDLSSNRFDVSTVPLCLGNLRDLRILNLANNSLSGQIPSSLGNLWQLSTLHLNGNKFVGKLPTSMQHLRNLEILDLGDNGLKDIIPAWIGERLSNLRFLRFQSNNFHGPISDTLCQLSLLQLLNLGHNNLRRESEYYASSLGFVKSISLSANNLVGEIPDGIMELVQLQVLNLSQNHLTGRIPKKIGNLKQLETLDLSMNALFGAIPESLSDLYSLNSLNLSYNKLSGPIPSGNQLQTLTDPSIYEGNSGLCGKPLPNNCWEHKLPAKNGPIDDDEGHSESDWSWFYAGIGPGFAAGLSGVLGILLFKKSWRYAYFKFIESACDKIWVKTTRPRRNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBE7</accession>
    <name>A0A068UBE7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DETOXIFICATION</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020614001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBE7"/>
    <dbReference type="Gramene" id="CDP05519">
        <property type="protein sequence ID" value="CDP05519"/>
        <property type="gene ID" value="GSCOC_T00020614001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBE7"/>
    <dbReference type="OMA" id="RARIHIT"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBE7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15200" checksum="26EA2809FB1482D3" modified="2014-10-01" version="1">MTLFHISGNYKILKGRQQHKYLRRTMRVRQDIGPFISYHLLNQCHLLAPGVARGSGWQHLGAYVNLGAYYLVGIPVALILGFALHVGGMGLWSGLVAGATVQSLLLSIITGLTSWENQVIEARRRIYEGEEEKATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCE9</accession>
    <name>A0A068UCE9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00022868001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCE9"/>
    <dbReference type="STRING" id="49390.A0A068UCE9"/>
    <dbReference type="Gramene" id="CDP06195">
        <property type="protein sequence ID" value="CDP06195"/>
        <property type="gene ID" value="GSCOC_T00022868001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCE9"/>
    <dbReference type="OMA" id="SHWRIET"/>
    <dbReference type="OrthoDB" id="7729168at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCE9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF37">
        <property type="entry name" value="PGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="9">
        <location>
            <begin position="260"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="455" mass="51319" checksum="DB6D94E1732715F7" modified="2014-10-01" version="1">MERLEMEKRLYGAAFEGNENTLHELLQEDKLVLDRVSLACFNYNNPLHIAINRGHEKFVEAILDHNPELLGNLEDSRQKWSSLHLASARGQLRIVEALVSVDPERCFDSDQDGRNPLHIAAIKGKIEVLEVLVDARPFAAREKTKRGETILHLCVKYHQLEALKKLVEAVDDDEFLNQTDGDGLTILHLAVIGKQIEIINYLLTTRIELNARNAKGQTALNMVPQNPKDRQKEIEKSLRQADALTADEITNQQSNFDQVKWLEQKIKALMVVASLIANMAFQAGINPPGGVWQDDQTEHSQENPSLNNAHDAGQSIMAYHKIQFYRFFISFNTIAFVSSLGTISLLISGLPFRRRVFMRILNGVMWLTATSILLSYGISVAFVTPESTKQRPGNVAVVAWSFVITIYLLGIAAAYSTNTWWKLCGRIKWRSRNSVSAVIENNRNGNLVELQIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD20</accession>
    <name>A0A068UD20_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00023199001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD20"/>
    <dbReference type="STRING" id="49390.A0A068UD20"/>
    <dbReference type="Gramene" id="CDP06376">
        <property type="protein sequence ID" value="CDP06376"/>
        <property type="gene ID" value="GSCOC_T00023199001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD20"/>
    <dbReference type="OMA" id="DYHAQNE"/>
    <dbReference type="OrthoDB" id="633301at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD20"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36897:SF2">
        <property type="entry name" value="OS10G0350800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36897">
        <property type="entry name" value="OS10G0351100-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="736" mass="81263" checksum="1CF3D374D220E05E" modified="2014-10-01" version="1">MVVTPPISRADGVTQHPFASRCPFLAAMVLTQAMKNFPTYIPHLEAPTLRTHSISLFASSPNAAVSSKFCSASLLKTEREDNFLDGVNTAPTANATLPTMADIIEASKRQNLDLHLQSLGPFFRIIAKTLITGNELGRAEGLVRLWLGGKILHLDSIKLRRETLEMEKSIFGIGLYIGAVAIRYGYNCGCKKAELLAINDTDLYHSPLVLVRTFPIFPFSKGPFFFRILAREGGQLLLLFGQKAIAGIVFSRIPGTLPPPHFPPHSPPLSFSTSLILLSSMEDDKKKKKNKKRKNKQNKTTADSAPGDAPGAFSVSPSAQHIPVTESAKISSALVDNPDAQEDDTASGMTLNPHGVIFEEKIQILLQEKNAILQKEATLLEKIEELQNEKAVHVQREASLEEQILQLQKEKDAFMLKVDALGQKIQQMQMEKDAHMQKESALEAEVGHLTSEKESWYHKEAHFEEKINHLTVEAATLSSKKVSLEEFVKQMEEERDSWILQENSSKEVIAKLNGDNTRLKSQVMELEELRNGLLQENHLLTENISGLQSQILSLERTAIVSQSSSGSKMMNELYVEIDRNGLQQEIPSAEMPTTVHLADSTAVGPHLMVGAIEAQESCPANDSMDEANAKMLVPDNEVQSPENNVNNDARGEGEYLDDKKDMLVTESSDMTKSDEIVQIPLDENENKKTDVEATSNAEKTLVPLSDAPLIGAPFRLISFVARYVSGADLVEKNSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEI0</accession>
    <name>A0A068UEI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00023923001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEI0"/>
    <dbReference type="STRING" id="49390.A0A068UEI0"/>
    <dbReference type="Gramene" id="CDP06886">
        <property type="protein sequence ID" value="CDP06886"/>
        <property type="gene ID" value="GSCOC_T00023923001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEI0"/>
    <dbReference type="OMA" id="MPRRTHH"/>
    <dbReference type="OrthoDB" id="753675at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF11">
        <property type="entry name" value="CASP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="8">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="22690" checksum="BF62D9A4FC86D32A" modified="2014-10-01" version="1">MEPSHSTKSNPETAILIDSKSAKGKSTAAPAAITATTKATPYRKGGWKRGVAIFDFILRLCALIATLTATITMGTTDQTLPFFTQFFQFQASYDDLPAFSYFVVANAIASGYLVLSLPFSIVCIVRPHAAGARLALLIFDTMLLAFTTAAAASAAAIVYLAHNGNQNANWLAICQQYTDFCQRVSGAVVASFMAAVTFVFLVVLSAVALRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEU9</accession>
    <name>A0A068UEU9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00024109001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEU9"/>
    <dbReference type="STRING" id="49390.A0A068UEU9"/>
    <dbReference type="Gramene" id="CDP07026">
        <property type="protein sequence ID" value="CDP07026"/>
        <property type="gene ID" value="GSCOC_T00024109001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEU9"/>
    <dbReference type="OMA" id="DDHKFEQ"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEU9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374">
        <property type="entry name" value="ZINC FINGER PROTEIN ZAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374:SF456">
        <property type="entry name" value="ZINC FINGER PROTEIN ZAT5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="335" mass="36490" checksum="6F8EABC49914DE46" modified="2014-10-01" version="1">MDALEEFSGSNDHSIVIKGKRTKRRQRPLSPVGRAAVVTSSSSSGGGGDDQGGGKDGEVLGYIYSLIPSCNTSTSDISISATSTDQEDEDMANCLILLAQGESCRKQVDQDRESKMEKFTSRRFNEMATTTTGGKVGFFVYQCKTCNRTFPSFQALGGHRASHKKPKINIEDNKATIVTPSNDHHHHQEEEEEEEEEKESAGEEQAAGQLIGRQSPPLSIQSTNKPCSTAASNKASKSHECSICGAEFASGQALGGHMRRHRNSMTASTSKVATILETSPSIDHHDQKPRNIFPLDLNLPAPSEDDVHRDLKFQFSANQQPHLVFSAPALVDCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG61</accession>
    <name>A0A068UG61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024320001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739109">
        <property type="protein sequence ID" value="CDP07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG61"/>
    <dbReference type="FunCoup" id="A0A068UG61">
        <property type="interactions" value="2290"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG61"/>
    <dbReference type="Gramene" id="CDP07169">
        <property type="protein sequence ID" value="CDP07169"/>
        <property type="gene ID" value="GSCOC_T00024320001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG61"/>
    <dbReference type="OMA" id="YWHDMEF"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="176"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="420" mass="47654" checksum="F396F8B352D3D2A7" modified="2014-10-01" version="1">MLDGYFSPKTKLFFFFRTSHRTSNMASTAAADADAATATKEAIENLWEEVRELSLGSTTTQIDHLPSPPTPLQFLRDYISPNKPCLIYNSISHWPALSLWPSTSYLQETLKSSPVSLHLTPTGRADSLIPHPHSNRSSSPLVFASAHVEKVPFSTALKRVSESSTCTEKGAKRCVGYLQEQNDCFRNEYGDLSQDCDDHIPWASEALGCLPEAVNLWIGNQLSVTSFHKDHYENLYAVITGEKRFLLLPPTDVHRMYIRDYPAAQYRYSEDTEDFELEIEDPVRYVPWCSVDPYPSFEGINRQMAEFPLYYNGPKPFEVTVKAGQVLYLPSMWFHHVSQCPDSRGLTIAVNYWYDMRFDIKYAYFNFLQSINYISDSAFWGGHVDSHSKVSASKGEDELEMIEFVPNGDATGQGVSDYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH77</accession>
    <name>A0A068UH77_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BZR1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein BRASSINAZOLE-RESISTANT 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00024852001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions in brassinosteroid signaling. May function as transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the BZR/LAT61 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH77"/>
    <dbReference type="FunCoup" id="A0A068UH77">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UH77"/>
    <dbReference type="Gramene" id="CDP07559">
        <property type="protein sequence ID" value="CDP07559"/>
        <property type="gene ID" value="GSCOC_T00024852001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH77"/>
    <dbReference type="OMA" id="FNNFSAC"/>
    <dbReference type="OrthoDB" id="775852at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH77"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008540">
        <property type="entry name" value="BES1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033264">
        <property type="entry name" value="BZR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31506">
        <property type="entry name" value="BES1/BZR1 HOMOLOG PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31506:SF22">
        <property type="entry name" value="PROTEIN BRASSINAZOLE-RESISTANT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05687">
        <property type="entry name" value="BES1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1070">Brassinosteroid signaling pathway</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BES1/BZR1 plant transcription factor N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="333" mass="35460" checksum="B9791B704E1292D0" modified="2014-10-01" version="1">MMWEAGGSTASSSAAGGSGGGGGGGGEGGGSGGVVNGRRKPSWRERENNRRRERRRRAIAAKIYAGLRAQGNYNLPKHCDNNEVLKALCAEAGWIVESDGTTYRKGCRPPPIEIGSTSANITPSSSRNPSPPSSYFASPIPSYQPSPLSSSCPSPTRQEPNMASHPFAFLRNSIPSSLPPLRISNSAPVTPPLSSPTRLPKQIFNLEALAKESMNALNIPFFAASAPASPTRGQRFTPATIPECDESDSSTIDSGQWMNFQTYAPNMVPTSPTFNLMKPMAQPVSPMDVVSGKGKGIEFDFEKLPVKAWEGERIHEVGLDDLELTLGSGNARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHN8</accession>
    <name>A0A068UHN8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00025034001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHN8"/>
    <dbReference type="STRING" id="49390.A0A068UHN8"/>
    <dbReference type="Gramene" id="CDP07694">
        <property type="protein sequence ID" value="CDP07694"/>
        <property type="gene ID" value="GSCOC_T00025034001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHN8"/>
    <dbReference type="OMA" id="PLPEMWV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHN8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13985">
        <property type="entry name" value="STKc_GAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000349">
        <property type="entry name" value="probable serine/threonine-protein kinase DDB_G0280111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="301" mass="34438" checksum="1FEB60FD139C6151" modified="2014-10-01" version="1">MWRFKPFMPKEQAGLEGRTIDIGNLKIQVRNAIAEGGFSCVYLARDAIHGTKQYALKHIICNDEESLELVMREISVMKLLKGHPNVVPLSAHTIFDMGRTKEALLVMDYCEKSLVTMLDNRGAGFLEEKQIFTIFRDVCNAVFAMHCQSPPIAHRDLKAENLLLGPDGLWKLCDFGSTSTNHKRFEKPEEMGIEEDNIRKHTTPAYRAPEMWDLFRRDIISEKVDIWALGCLLYRICYLKSAFDGESKLQVLNGNYRIPELPKYCTSLTDLIRDMLQSSPDSRPDITQASTFLDWLLLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI84</accession>
    <name>A0A068UI84_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00024574001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="10">The crystal structure with reduced Cu(1+) has also been determined.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Plastid</location>
            <location evidence="2 11">Chloroplast thylakoid membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
            <orientation evidence="2 11">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the plastocyanin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI84"/>
    <dbReference type="FunCoup" id="A0A068UI84">
        <property type="interactions" value="1099"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UI84"/>
    <dbReference type="Gramene" id="CDP07338">
        <property type="protein sequence ID" value="CDP07338"/>
        <property type="gene ID" value="GSCOC_T00024574001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI84"/>
    <dbReference type="OMA" id="YDYYCEP"/>
    <dbReference type="OrthoDB" id="197281at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI84"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009543">
        <property type="term" value="C:chloroplast thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04219">
        <property type="entry name" value="Plastocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001235">
        <property type="entry name" value="Copper_blue_Plastocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02656">
        <property type="entry name" value="cyanin_plasto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34192">
        <property type="entry name" value="PLASTOCYANIN MAJOR ISOFORM, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34192:SF10">
        <property type="entry name" value="PLASTOCYANIN MAJOR ISOFORM, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00156">
        <property type="entry name" value="COPPERBLUE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0186">Copper</keyword>
    <keyword evidence="6 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="12">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602387-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="167" mass="16820" checksum="1D2804FD0EF755C5" modified="2014-10-01" version="1">MATVTSAAVSIPSFTGLKASGAPASRVSSTVKVFAASPKLAVKASLKEVGAAVVATAASAMLATNALAAEVLLGSSGGELIFVPSEFSVASGEKIVFKNNAGFPHNVVFDEDGVPSGVDATKISMSEEDLLNAPGETYSVSLTEKGTYTFYCSPHQGAGMVGKVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ51</accession>
    <name>A0A068UJ51_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00026975001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ51"/>
    <dbReference type="STRING" id="49390.A0A068UJ51"/>
    <dbReference type="Gramene" id="CDP08214">
        <property type="protein sequence ID" value="CDP08214"/>
        <property type="gene ID" value="GSCOC_T00026975001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ51"/>
    <dbReference type="OMA" id="GHTCLYN"/>
    <dbReference type="OrthoDB" id="191334at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044174">
        <property type="entry name" value="BC10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042">
        <property type="entry name" value="CORE-2/I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042:SF8">
        <property type="entry name" value="CORE-2_I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="294" mass="34008" checksum="423EAF6D8FFF10F1" modified="2014-10-01" version="1">MSDEELFWRASLVPQIKKYPFNRVPKIAFMFLTKGPLPLAPLWERFFKGHSGLYSIYIHSLPSYQADFPPTSVFYGRQVPSQVAEWGRMSICDAERRLLANALLDLNNEWFVLLSESCIPLYNFSIIYHYITKSKYSFVGAFDDPGPFGRGRYNENMAPEVQISQWRKGAQWFQINRKLALIIVADTKFYPKFAEFCRSPCYVDEHYFPTMLTIQAPNQLANRSITWVDWSRGGAHPATFGSADITEPFIRGILENHTCPYNDQPTSICHLFARKFAPSTLQPLFFLAPKYFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJG2</accession>
    <name>A0A068UJG2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pseudouridine synthase</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027170001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJG2"/>
    <dbReference type="FunCoup" id="A0A068UJG2">
        <property type="interactions" value="2846"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJG2"/>
    <dbReference type="Gramene" id="CDP08364">
        <property type="protein sequence ID" value="CDP08364"/>
        <property type="gene ID" value="GSCOC_T00027170001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJG2"/>
    <dbReference type="OMA" id="EPPVMAC"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJG2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000036">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="9">
        <location>
            <begin position="115"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="377" mass="42609" checksum="FE7CAB1CB590E20A" modified="2014-10-01" version="1">MEIVWQTPANPPDRHDYILRDGMRYVRPYYFEFISHVKNRWANKTIVDLFTEEFKGRPRDYYVSAVKAGRIQVDGRIVPISYVVQPSQKISHFVHRHEPPVMAWDIEILHREAEVLTVSKPASVPVHPCGQYRKNTVVGILQAEHGLAPLFPIHRLDRLVSGLLILARSASRADLFRQQIESGMVQKQYIARVDGVFPEDEQVVDANVNYNAREGMSTVEVGDDYINGNASAKGKSACTKFTRINTNGSHSIVLCEPITGRTHQIRVHLQCTGHPIANDMLYLSKSVTKRSSEGLGADRAAAKSNLSVDQSSHQNHKDEADNVAEEDFRIDPMCTNCPNLAPKGYDGHEEGLWLHCVKYTGPDWVYECPYPDWAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJI5</accession>
    <name>A0A068UJI5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="8">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027221001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739116">
        <property type="protein sequence ID" value="CDP08394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJI5"/>
    <dbReference type="FunCoup" id="A0A068UJI5">
        <property type="interactions" value="2909"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJI5"/>
    <dbReference type="Gramene" id="CDP08394">
        <property type="protein sequence ID" value="CDP08394"/>
        <property type="gene ID" value="GSCOC_T00027221001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJI5"/>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJI5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="14436" checksum="ED5484A0885D5849" modified="2014-10-01" version="1">MSRSLGIPVKLLHEATGHIVTVELKSGELYRGSMIECEDNWNCQLENITFTAKDGKVSQLEHVFIRGSKVRFMVIPDMLKNAPMFKRLEARIKGKGSALGVGRGRAVAMRARAQAAGRGAPPGRGVVPPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJZ4</accession>
    <name>A0A068UJZ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027863001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJZ4"/>
    <dbReference type="Gramene" id="CDP08771">
        <property type="protein sequence ID" value="CDP08771"/>
        <property type="gene ID" value="GSCOC_T00027863001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJZ4"/>
    <dbReference type="OMA" id="YRPKFGF"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJZ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phytosphingosine metabolic process"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="entry name" value="ATP-NAD_kinase_N"/>
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        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00147">
        <property type="entry name" value="YegS/Rv2252/BmrU family lipid kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF54">
        <property type="entry name" value="SPHINGOSINE KINASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="34"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="349" mass="38064" checksum="C02701C8B0A831E5" modified="2014-10-01" version="1">MAKPACLIRAEQPLATDLTAADRSTISLAGSASSRLRDVVFVVNPRGSNGRTGEQWKKLLPYITSRLGSDCNICESLTSGPCHAIDITREAIREGAQAVVAVGGDGTLHEVVNGFFWGGEPVASHDPKSSHKTALGLIPLGTGSDFARTYGWKNDPHDAIERIAKGLRSRIDVGVISGESGDPHYFINEADIHLSAKAGYYASRYKKFGNLCYVIGALQAFFRHQNRDLRIKVDGGEWEVCSQVTALCVGNAKYFGGGMKIAPNADPSSGNFEVVILQDFRWHDFILNLHKLYNGTHLSVKNVFSRSVQSIEVEEIIPSDSIYVQSDGEYLGFLPRKFCILPGAIEMIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKP0</accession>
    <name>A0A068UKP0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00026910001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKP0"/>
    <dbReference type="STRING" id="49390.A0A068UKP0"/>
    <dbReference type="Gramene" id="CDP08163">
        <property type="protein sequence ID" value="CDP08163"/>
        <property type="gene ID" value="GSCOC_T00026910001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKP0"/>
    <dbReference type="OMA" id="MAPAMIR"/>
    <dbReference type="OrthoDB" id="2012132at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKP0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009646">
        <property type="entry name" value="Root_cap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31656">
        <property type="entry name" value="ROOT CAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06830">
        <property type="entry name" value="Root_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657759" description="Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48961" checksum="4504F1290F0AB83B" modified="2014-10-01" version="1">MAPAMIRHLLASVVLLMAVMANGQPTGSKHRTARCADRKFSACYSQPAQYCPAECPNYCAVDCFRCLPVCVPKPPPGPPPPPRRRRSPPPPRPPPPPRRRRSPPPPRSPPPPPTSNSTPPPLTPPTSSPPPLATPPPLSPPPASSTPSPPPEVSGKRVHCKNKNYTKCYRMEQRCPSSCPDQCEVDCVTCSPVCNCNKPGAVCQDPRFIGADGITFYFHGKKDQDFCIVSDSDLHINAHFIGKKSENMTRDFTWVQSLGILFDNHQIFVGAKRTATWDNAIDRLDLDFDGQQILLSEGEGSKWLPATAPGVSITRSLDVNAAVIEVEGNFQIKATVVPITEKESRIHKYGVTDEDCFAHLDLSFKFYSLSGAVNGVLGLTYSSNYVSRAKMGVDMPVLGGQKEFASSSLFSTDCSVAQFSGTPPISTTNNVEYSNMNCASGFDGRGVVCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL59</accession>
    <name>A0A068UL59_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst subunit Exo70 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028141001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL59"/>
    <dbReference type="FunCoup" id="A0A068UL59">
        <property type="interactions" value="1761"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL59"/>
    <dbReference type="Gramene" id="CDP08984">
        <property type="protein sequence ID" value="CDP08984"/>
        <property type="gene ID" value="GSCOC_T00028141001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL59"/>
    <dbReference type="OMA" id="LHITMHR"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL59"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.170:FF:000003">
        <property type="entry name" value="Exocyst subunit Exo70 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF17">
        <property type="entry name" value="EXOCYST SUBUNIT EXO70 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="254"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="652" mass="73202" checksum="AE5808C998A60461" modified="2014-10-01" version="1">MRNKIFLSPLTSPTSSHSSSHSSKTSPHTLSATIMEENVDCAEVIIRKWDLNATDSARLYSSNTPSLFAQDHRSQAQQFIKSVNDLQSAMHFFVSEDPGSPMLIRAQNLMQIAMKRLEKEFYSVLKTNMTALHPESVSLRSSSSRASSTWSAFSDFQNRETSEGEDDDDEITTDIDQIHIKSNKTEKVYEDVMSDLRVIANCMISSGYGKECTHIYNLIRKSIIDETLYYLGVEQLSSSQLQKMAWDDIEVKIKKWLAAVKTAVKTLFHGERVLCDHVFCASEKIRETCFTEISRGNALTLFSFPENVARCKKIFSPEKMFRFLDIYEAVSELWIDIGMIFSFDSLSGVRAQAMTSLLKLGEAVRTMLLQFESAIEKDSSKTAVPGGGVHPLARYVMNYLVFLTDYSGALADIVADWPTSVQTSLPESYLSSPISANDVDDDSPASTISVRLAWIILVLLCKLDGKAGCYGDHVALSYLFLANNLNYVVSKVKTSNLMPLMGPDWVSKHESKGKQYSAKYERMGWAKVLTSLPDDPTVEISLPEIKDSFRKFNSGFEEAYRVQSSWVIPDSKLRDQIKFSLSEKMVPGYRVFYENHREEVGDESIVRFTPDDLENCLSDLFQGRSEGMGSSRATSYRVSSVSTSPSSSWTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL89</accession>
    <name>A0A068UL89_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028404001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL89"/>
    <dbReference type="STRING" id="49390.A0A068UL89"/>
    <dbReference type="Gramene" id="CDP09181">
        <property type="protein sequence ID" value="CDP09181"/>
        <property type="gene ID" value="GSCOC_T00028404001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL89"/>
    <dbReference type="OMA" id="MIVIHEA"/>
    <dbReference type="OrthoDB" id="1662328at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="225" mass="24909" checksum="6D0E980F41D958CF" modified="2014-10-01" version="1">MALLITYDEHGGFYDHVPTPVEGVPNPDGIIGPDPYYFAFDRLGVRVPTLLISPWIDKGTVIHEPNGPTPQSQFEHSSIPATVKKLFNLKSNFLTKRDAWAGTFENAFKLRETPRDDCPEKLPEVKQSLRPGGPREDVELSEFQLELIQLASQLNGDHVLNAYPDIGKGMTVGEANRYAEDAVERFLEAGRAALRAGANESAIVIMKPSLTTRTAAVDARYLETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULL5</accession>
    <name>A0A068ULL5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028665001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULL5"/>
    <dbReference type="FunCoup" id="A0A068ULL5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09341">
        <property type="protein sequence ID" value="CDP09341"/>
        <property type="gene ID" value="GSCOC_T00028665001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULL5"/>
    <dbReference type="OMA" id="EENCHSM"/>
    <dbReference type="OrthoDB" id="632588at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULL5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049198">
        <property type="entry name" value="DUF6865"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35282">
        <property type="entry name" value="F5D14.24 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35282:SF2">
        <property type="entry name" value="F5D14.24 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21737">
        <property type="entry name" value="DUF6865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="82" mass="8858" checksum="3EFBB308131213F7" modified="2014-10-01" version="1">MDKIESGKEVSEELTRESLIAISYTAPEKEAAARNSNENLTGENVVAATKVDGNDTYRSKLISISYTESPDAKTLPVLPGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM17</accession>
    <name>A0A068UM17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">GSCOC_T00029018001</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM17"/>
    <dbReference type="STRING" id="49390.A0A068UM17"/>
    <dbReference type="Gramene" id="CDP09585">
        <property type="protein sequence ID" value="CDP09585"/>
        <property type="gene ID" value="GSCOC_T00029018001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM17"/>
    <dbReference type="OMA" id="CCTECPR"/>
    <dbReference type="PhylomeDB" id="A0A068UM17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF73">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 25" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658076" description="non-specific serine/threonine protein kinase" evidence="25">
        <location>
            <begin position="25"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="805"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CDP09585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122522" checksum="AC823CA9FE17EDA9" modified="2014-10-01" version="1">MGKIDHYLFLISFSLVSLAMMAAGNSNVTTDQLALLVLRDRMINSEPREILAKNWSITSSVCDWIGVTCGFRHHRVTALNISNMNLTGTLPPQLGNLSFLVSLNISRNNFHGELPGELVHLRRLRYLDFGINNLGGELPSWFGFLYKLQFLSLGNNSFMGSIPPSISNMSNLETLLLSFNFIEGTVPIEFQNLHNLKNLLIEYNQLSGPLPLHVFNLSSLQIISFMSNSLSGILPDDACQRLQKLTWLSLEYNNLIGRIPSTVSQCSLLRYLASSENRLSGPIPMGIANLTMLEELYLESNNLTGKIYLISLCFCSSIWRFQRNRTFFLAVLIDSDEKAQPLSLSLSLSLCNFAGAIPNEIGNLTMLTALDFHNNKLIDSSKISSLFVTTFLHYKSNQTHKSCNFVGAIPNEIGNLTMLTILYFYDNKLTGVIPAEIGNLAMLMDLDFSNNKLTGGIPEKIGNLHRLEELYLYNNALSGSIPAAIFNISSLQHIGLDQNKFSGTIPLTVSNNKLSNLESLFLERSSIPTSLASLRNLKYLYLDYNRLSSESSELSFFTFLTSSRSLTYLVLGNNPLNGFLPASFSNYSTSLEVITAKSCRIKGNIPDGISNLSSLVELEFSGNELIGSVPRTIHNSNRLTSMIPTNLLSMKDLQILNLSSNFLSGSLPLEIGNLKAAYSLDISFNQLSDKIPTTIGELQALQSLSLANNNLQGQLFMNNEGLCGDPRLSVPLCQSNSIRRSSKRKVLLLVISLSGMAAILIIAIGALLNLRWLKKPKSSSGIELMSAAKYERFSYYDLLHSTDNYNESNLLGEGSYGSVYKGILSDGTIVAIKVFNLLVEGSLKSFDKECEVLKSLRHRNLIKVLGSCCNPNFKALVLKYMPNGNLEKWLYSHNHFLDMFQRINIMIDVACALEYLHYGYDAPVVHCDLKPSNILLDEDMAAHVSDFGIAKMFGQGESILHTNTLATLGYIAPEYGSEGIVSTRIDVYSFGIVLMEIFSRMRPSDETFSGDLSLKSWVEDSLPNALQVVDANLIRPEDEHFTDKLKCVTLIMKLALNCCTECPRERISMKDVFAELIKIKHQFQFLMTVSIYPFCANFTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMJ7</accession>
    <name>A0A068UMJ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00030185001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMJ7"/>
    <dbReference type="FunCoup" id="A0A068UMJ7">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMJ7"/>
    <dbReference type="Gramene" id="CDP09735">
        <property type="protein sequence ID" value="CDP09735"/>
        <property type="gene ID" value="GSCOC_T00030185001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMJ7"/>
    <dbReference type="OMA" id="FRVWEHE"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMJ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF19">
        <property type="entry name" value="OS04G0619700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP09735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="554" mass="62250" checksum="68EA476C4CF0E6CF" modified="2014-10-01" version="1">MAFECQKDTGSCLKKDLADFSDNFADQEVDTDSSNNLKKVIFEFGKVKPKSSFHAKGGNSSSTSENLVPAAEVLPNSCRSITDLPQALISEILNCLDPKELGIVSCVSKFLYWLASEHDVWKEFYCERWGHPITPALELQDTDERSWKELFVEREFRSKTFLGRYSIDALYGHTEAVRTVFVLASKKLIFTSGYDQIVRVWNMEEGLSIASSRPLGCTIRAVAADARLLVAGGTDGFIHGWRTEDGNPHLFDLKAQNQNLEFRLWEHEGPITCVALDFTRIYSGSWDMTVRIWDRSTLKCLNVLVHSDWVWSLVPHENTVATAAGSDVYIWDINTGMQLAVINNAHVGNSYSLARSHTGKLLFTGGEDGAIHMFEVTTNLGCKVQKIAKWIPHTGPVFSLAFEFPWLVSASSDGKLSLIDVRKLLKMSRDSLTEKSSKVVHLDEKNVEPPQRMLHGFGSNLFSVDVGPDRIVCGGEEGVVRIWNFSQALEIEKRVRALRGLRLENRMRRRKLQTEMSSKTGRSDQCSVAAKKNQIGGDRNSWHNRRRVSGKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNJ9</accession>
    <name>A0A068UNJ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00030716001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polygalacturonase-inhibiting protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNJ9"/>
    <dbReference type="FunCoup" id="A0A068UNJ9">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNJ9"/>
    <dbReference type="Gramene" id="CDP10105">
        <property type="protein sequence ID" value="CDP10105"/>
        <property type="gene ID" value="GSCOC_T00030716001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNJ9"/>
    <dbReference type="OMA" id="VRCNPND"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNJ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000348">
        <property type="entry name" value="Polygalacturonase inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF4">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655050" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="334" mass="36678" checksum="A7C8BFF406286D67" modified="2014-10-01" version="1">MQASIGFVVFLSLYLFLSLPYPSLGANAKCNSNDRKALLQIKAAFIDRYHFVSWAPDVDCCEWYGLECDPNTGRVITLSVLAGNLSGQIPPAIGDLTDLQILIFHKLSNVTGQIPSAISKLVHLKQLILSNTNLSGPVPSFLGQLKNLTFLDLSFNNLAGSIPPSLFELPNLGGLRLDRNKLTGSIPDSFGNFVGTAPDLYLSHNMLSGPLPKSIGNVNFTLEIDFSRNNLQGDPSLLFGKNKTVHFVDLSRNLFEFDLSKVEFPDSLTNLDLNHNKIFGSLPNGLTELTLQFFNVSYNSLCGQIPQGGKLQSFDNYTYFHNRCLCGAPLPDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP54</accession>
    <name>A0A068UP54_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028766001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP54"/>
    <dbReference type="Gramene" id="CDP09413">
        <property type="protein sequence ID" value="CDP09413"/>
        <property type="gene ID" value="GSCOC_T00028766001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP54"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="200" mass="22384" checksum="761584BA3F8BCF89" modified="2014-10-01" version="1">MLPEIKVGIRYFLSFGGSFRHLAKNYSHSRPSLAATFVSGLRFFFFFFGGFFWTLQRLNKSDGDESWVRSNGILRNLGKYFTTVGPFSAGFGGSSTARSGGSAGAMVALLPARRQFSSWSTRNLKRELRELMAEFKELSFSECLHLTIASSVTAYLLHSTVRGIAKLTKSVWSRTGIANLKFSSKRFVLFICVVTYCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPD6</accession>
    <name>A0A068UPD6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028878001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPD6"/>
    <dbReference type="FunCoup" id="A0A068UPD6">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPD6"/>
    <dbReference type="Gramene" id="CDP09493">
        <property type="protein sequence ID" value="CDP09493"/>
        <property type="gene ID" value="GSCOC_T00028878001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPD6"/>
    <dbReference type="OMA" id="ASWLIQV"/>
    <dbReference type="OrthoDB" id="1925570at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPD6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36074">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36074:SF1">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="331" mass="36666" checksum="CB741C7895025874" modified="2014-10-01" version="1">MAGIAIVMDLLRKNPSLTGRTVHSYGLFSAKVAASAAATSAAAMAPFATWAFFGKGVPQVAYCDAGAAINGDYISRIRSVSENVFEEEDSVDYSTKEYIIELKPLFSAFHWKTLALTSLRSFLLFYLPLLEPHANMDDDDDDFLQDTHEERVNLVVPFKKSVKQIVRETTVVTTRRVLERLAVHYVSQRLAWKLLKDTPKSAARKAQRGMPTLTYIYSVGRTTFRGHFLAVLASWLVQVGIDVYRFFSRICGSKEETDEIDRAAELQLLGRKIYIATLRCGASLIFASIGAGLGAIIIRPTTGQWIGCALGDLAGPVILSLCFEKLFHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQ08</accession>
    <name>A0A068UQ08_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031274001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQ08"/>
    <dbReference type="FunCoup" id="A0A068UQ08">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQ08"/>
    <dbReference type="Gramene" id="CDP10521">
        <property type="protein sequence ID" value="CDP10521"/>
        <property type="gene ID" value="GSCOC_T00031274001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQ08"/>
    <dbReference type="OMA" id="MQKEYNA"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQ08"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015145">
        <property type="term" value="F:monosaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17361">
        <property type="entry name" value="MFS_STP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000002">
        <property type="entry name" value="Sugar transport protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044778">
        <property type="entry name" value="MFS_STP/MST-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500:SF109">
        <property type="entry name" value="SUGAR TRANSPORT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="30"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="510" mass="55378" checksum="94D65830A50649DD" modified="2014-10-01" version="1">MAGGSSAPTGVSKERAEQYQGRVTAYVIVACIVAAVGGSLFGYDIGISGGVTSMDGFLSKFFPTVYRHKMHAHENNYCKYNNQGLASFTSSLYLAGLVSSLVASPITRKYGRRGSIICGGISFSIGAALDASAQNLAMLILGRIMLGFGIGFGNQAVPLYLSEMAPTHLRGGLNMMFQLATTLGIFTANMINYGTEKLRPWGWRVSLGLAAAPAILMTVGGILLPETPNSLIERGSEEKGKKVLEKIRGTTNVHAELQDIIDASELANSIEHPFRNILEKKHRPELIMSIFMPTFQILTGINSILFYAPVLFQTMGFAGNASLYSSAVTGAVLASSTLVSIATVDRWGRRVLLIGGGIQMIICQVIVAIILGLKFGSDRELSKGFSILVVVVICLFVAAFGWSWGPLGWTVPSEIFPLEIRSAGQSITVAVNLLFTFAIGQAFLSLLCAFKFGIFLFFAGWITIMTIFVYLFLPETKGVPIEEMVFLWRKHWFWKRVLPKDLESSKNGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URH4</accession>
    <name>A0A068URH4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00033028001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URH4"/>
    <dbReference type="FunCoup" id="A0A068URH4">
        <property type="interactions" value="1487"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URH4"/>
    <dbReference type="Gramene" id="CDP11041">
        <property type="protein sequence ID" value="CDP11041"/>
        <property type="gene ID" value="GSCOC_T00033028001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URH4"/>
    <dbReference type="OMA" id="MDINWFE"/>
    <dbReference type="OrthoDB" id="2779at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URH4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042548">
        <property type="term" value="P:regulation of photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08866">
        <property type="entry name" value="SRPBCC_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34060:SF2">
        <property type="entry name" value="OS03G0837900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34060">
        <property type="entry name" value="POLYKETIDE CYCLASE / DEHYDRASE AND LIPID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="2">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="2">
        <location>
            <begin position="355"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="727" mass="82975" checksum="690F33827A655A89" modified="2014-10-01" version="1">MIEVISKAPSSIHLAFTPDVSFECKLRNITCGLKSCLQKRCVALCSISDKPKWSSNGHMPNDGHSKYRNHHKNYSSEEEEEERKVHCEVQVISWRERRIKAEVVVNADVASVWDALTDYERLADFVPNLVSSMRIPCPHPGRIWLEQRGLQRALYWHIEARVVLDLQEFQTSANDHELQFSMVDGDFKKFEGKWSVKSGKRFSKTTLSYELNVIPTFNFPAIFLERIISSDLPVNLQAMACRAESTFKNSQNSLTDEAPPVTTLADSFTSTSSDVSGVASDKNDFPTGELKEKLLKATLSPLSPAKSELSSNWGVFGKVCKLDKPCMVDEVHLRRFDGLLENGGVHRCVIASITVKAPVPEVWNILTEYERLPEIVPNLAISKILSRENNKVRILQEGCKGLLYMVLHARVILDLCEVLEQEISFKQVEGDFDSFRGKWSLEQLGNHHTLLKYTVESKMRKNSFLSEAIMEEVIYEDLPSNLCAIRDYIETKVAENTSKAFDYSAYTNELFASSSNENAASNDEPANQNLSSTASDSSRQRPKVPGLQRDIEVLKSELFTFIAEHGQEGFMPMRKQLRRHGRVDIEKAITRMGGFRRIAALMNLSLAYKHRKPKGYWDNLENLQEEISWFQKSWRMDPSFMPSRKAFEQAGRFDIARALEKWGGLHEVSRLLSLKVRHPNRQASLAKERKMEVLAPNEDQAPSKPYVSQNTQKWLTKVKEFDINWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URV2</accession>
    <name>A0A068URV2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00033021001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URV2"/>
    <dbReference type="Gramene" id="CDP11037">
        <property type="protein sequence ID" value="CDP11037"/>
        <property type="gene ID" value="GSCOC_T00033021001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URV2"/>
    <dbReference type="OMA" id="CCTADAS"/>
    <dbReference type="PhylomeDB" id="A0A068URV2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF602">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="349"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="608" mass="67513" checksum="D916B46063F59FEC" modified="2014-10-01" version="1">MNRFTGPIPSKLFNVSSLRVISMVENDLSGSLPSSLGAMLPNLEELYIGGNRLSGVILTYISNASRLAYLDLTSNQFTGVIPRSLVSVGNLSSNLESFYMNDCGLFGQIPSSIGNLSNLADLNLSQNALEGTIPPTFGGLLKLQEMELGYNKFQGPCPSELCYLLNLGRLSLSSNLLSGRLPSCIGNITSLRYLYLDSNNLSFNLPSNLWRLRDILELNLSTNSFSGSFSSEIENLKALIIVDLSVNNFFGDIPTAIGALQSLQALSLKHNRLQGFIPESMKNMLELHSRKMTVLLVLLALGSVVVAMVVSFLVIRKWRRKIVSPSNLDPDTTFERVSSHELRQITIWFSESALLGSGTFGSVYKGIQENGMTWAIKVFYLQLDGAFKSFNRECKVLRCLRHRNLTMVFSACSNPDFKALILEYMPNGSLEKRLYSGTHILNIMQRLDIMIDVACGLEYLHYGYPTPVIHCDLKPNNILLDQDMVGHVCDFGIAKLLGDGESVVQTKTLATFEYVAPEYGLEGLVSTSCDVYSFGMTLMETFTKRRPKDEMFTEELSLQHWIACISSILELALCCTADASKDRMTMKDVLKALQKIKLQFSEGLKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USV8</accession>
    <name>A0A068USV8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00033640001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USV8"/>
    <dbReference type="Gramene" id="CDP11402">
        <property type="protein sequence ID" value="CDP11402"/>
        <property type="gene ID" value="GSCOC_T00033640001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USV8"/>
    <dbReference type="OMA" id="HIIPLMQ"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USV8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000061">
        <property type="entry name" value="UDP-glycosyltransferase 83A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000108">
        <property type="entry name" value="UDP-glycosyltransferase 83A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1412">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 83A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012045493" description="UDP-glycosyltransferase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52426" checksum="32D9E3DAD7E7D0C8" modified="2014-10-01" version="1">MGIPHVLAIPYTAQGHVLLLMELALCLVKSGIKVTFVNTEFDHKRVIESLSGEGNVPDMMHLVSIPDGLESWDDRNDLGKLTKTIFRVMPAKLEALMEKINESETDKITCLITDESMGWALEIAKKMGVRAVAFWPAAAAVSALELNIPKLIHDGIIDSSGKTPFSIMLLQKQNGEIWLLQNRLKLSPTILAMDSAHFVWACIGDPTTQGIIFYVILKNIRTLKLADWIICNSSNELETSVFNSYPEMLPIGPLLSSNRLGKLVGSYGPKDLDCLVWLDKQPVQSVIYVAFGSITVFDQTQFQELALGLERTNMPFLWVVRRNLTAETDNAYPKGFKERIQGRGRLSSWAPQQPVLSHPSVACFLGHCGWNSTVEGVSNGVPFLCWPYFADQFTNRSYICDDWKVGLGLEKDGNGIIAQGEVKNKIEQLVTVKGYKERALDLKAKVMNSLREDGCSGKNFNNFVKWIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTS4</accession>
    <name>A0A068UTS4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BCNT-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035277001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTS4"/>
    <dbReference type="FunCoup" id="A0A068UTS4">
        <property type="interactions" value="1637"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTS4"/>
    <dbReference type="Gramene" id="CDP11955">
        <property type="protein sequence ID" value="CDP11955"/>
        <property type="gene ID" value="GSCOC_T00035277001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTS4"/>
    <dbReference type="OMA" id="TMQERWT"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTS4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="3">
        <location>
            <begin position="173"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="263" mass="28845" checksum="2E119F5CB00E33F7" modified="2014-10-01" version="1">MNVQIMDGMKVESNQDVAPVPPPSHTLPEEVERKARVDAVWQQMNKGPSGKALKSTLKNQSSSINKISPKPSSQNWMKVLGLAPKKTSSAVEGAPGKRPIVAQNGSSDDAKKLAAAALSAVKDAAAAAAAASALGRGKMEVTELRDFAGEEIEFKKLVDTSSKEAFDKGKASTGPASAVDAVLEQIKKKQKLSVLDKTKKDWGEFKEENKGLEEELETYKKSSNQYLDKVSFLQRTDYREFERERDARLAMQAKRKADMREDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTV3</accession>
    <name>A0A068UTV3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30-like ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00033053001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTV3"/>
    <dbReference type="STRING" id="49390.A0A068UTV3"/>
    <dbReference type="Gramene" id="CDP11058">
        <property type="protein sequence ID" value="CDP11058"/>
        <property type="gene ID" value="GSCOC_T00033053001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTV3"/>
    <dbReference type="OMA" id="NCFPENT"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTV3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="15438" checksum="CD8737E33EC8735A" modified="2014-10-01" version="1">MHPRTKKILQLLRLRQIFNGVFLKVNKATLNMLHRVEPYYIWGSLTLFFVKELIYKRGYGKVNKQRIALIALTDNSIIEQALGKHSIICIEDLAHEILTVGPHFKEANNFLWPFKLKAPLSGLKKKRNHYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UU15</accession>
    <name>A0A068UU15_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00033153001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UU15"/>
    <dbReference type="Gramene" id="CDP11113">
        <property type="protein sequence ID" value="CDP11113"/>
        <property type="gene ID" value="GSCOC_T00033153001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UU15"/>
    <dbReference type="PhylomeDB" id="A0A068UU15"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="230"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="9">
        <location>
            <begin position="410"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP11113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="673" mass="76038" checksum="D667D4F8B09F1AD7" modified="2014-10-01" version="1">MGGIGKTTLAKLVYNNPQIDAHFDKKIWICVSENFQEVELFKLILESLTGRKVDLSSKDAIVKEIKKEMKDNRYLLVLDDVWNEKPKLWDDFFESLAGIVTTNGSRCLVTTRLGQVATIVSRHSPYLLGKLSDDDCWSILKEKAFSGGEVPEEFNLIRQQILKWCNGLPLAASVLGGLLRIKRKEEWLSIVENRLLNLKEGDNSVEQILKLSFDNLPSALIRKCFGYCSIFAKDSEIERDLLIELWMAEGFLEPVLCNQSLMEDVGDQYIRVLLHSSLLEEVKYNWKTCYKMHDLVHDLAESISKPECVKSENGGIDNYNQVRYLAINSSDGITRKILNDTSASVRTLFVTRSISGDMLPKFKNLHVLNLHGAGLKELPPSIGKLKHLRFLDLSNSGIKTLPESLCKLYTLQTLRIDCLRYQDGFPVQVESDNVEGDVLEGLRPHPNLQELYICGFMGDRFPYWFMSLTKLVDLSLIDCSTSKELPAGLGQLPFLQKLEFSGLENVRYIGPSFYGIDDDFGKVGGQLEVLSRTFFRALNVLTLKNMGNLVEWMEPDINVFPMLEILTIEDCSKLTTAPSHFPSLKILEITKNDHVSVVKKILSKVSTTLSSLTIIGNTGMTGLTCLSDIAMHWPVWILKCWSPVWLLSGCVFMTAQILSPSQSWRVCNKCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV66</accession>
    <name>A0A068UV66_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00033824001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Whirly family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV66"/>
    <dbReference type="STRING" id="49390.A0A068UV66"/>
    <dbReference type="Gramene" id="CDP11528">
        <property type="protein sequence ID" value="CDP11528"/>
        <property type="gene ID" value="GSCOC_T00033824001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV66"/>
    <dbReference type="OMA" id="DTREFFH"/>
    <dbReference type="OrthoDB" id="511009at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990391">
        <property type="term" value="C:DNA repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013742">
        <property type="entry name" value="Whirly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31745">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31745:SF1">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08536">
        <property type="entry name" value="Whirly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="126" mass="13942" checksum="66180C5D1ABF44BE" modified="2014-10-01" version="1">MHCFALSATEVGSMINMGPQDTREFFHDPAMLSSNAGQVRKSLSIKPHADGSGYFFSLNVVNNILKTNERLVVPVTAAEFAVMRTAFSFALPRIMGWDQYSNQPLGTAHKSPSKVLPHLTDSEWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVN9</accession>
    <name>A0A068UVN9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036081001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739151">
        <property type="protein sequence ID" value="CDP12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVN9"/>
    <dbReference type="FunCoup" id="A0A068UVN9">
        <property type="interactions" value="1441"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVN9"/>
    <dbReference type="Gramene" id="CDP12486">
        <property type="protein sequence ID" value="CDP12486"/>
        <property type="gene ID" value="GSCOC_T00036081001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVN9"/>
    <dbReference type="OMA" id="FGNTRFS"/>
    <dbReference type="OrthoDB" id="1919407at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015919">
        <property type="term" value="P:peroxisomal membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034571">
        <property type="entry name" value="APEM9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36361">
        <property type="entry name" value="PROTEIN APEM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36361:SF1">
        <property type="entry name" value="PROTEIN APEM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="39173" checksum="DFF02D61EBF984F9" modified="2014-10-01" version="1">MAVVCGAKASTWEGIERSESYLVSCMFEEAASLASLIIRNLMRENHQNGNVDNDGNENELHDMLESSGMVFVQSMKELARTFEILKELKHLFGSVAAIPVQVLVTGVCFQISEGTSSDVEGYLKEFLNKWIYKDEGYYFSVEADGEEPDRRFSLGVDEYLEVVDLYVMTCLGMVLRDIDSAISWVEKASLPEDKRQELLRRLNSMNASKATSSSQAPVSSLHADKHGVESKNFSKNLEPGHVASKENSVKETILKLSGRGAPCFWWFRNTTVKFGNFRLNLSNGNILLGCILLFMCYFLKRKQASLKRVLRKQALSVKKGLVDLWQLAFSYQVNPLAAVQPLPAATRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVR8</accession>
    <name>A0A068UVR8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00035920001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with PEX13; forming the PEX13-PEX14 docking complex. Interacts with PEX5 (via WxxxF/Y motifs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739148">
        <property type="protein sequence ID" value="CDP12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVR8"/>
    <dbReference type="FunCoup" id="A0A068UVR8">
        <property type="interactions" value="1619"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVR8"/>
    <dbReference type="Gramene" id="CDP12402">
        <property type="protein sequence ID" value="CDP12402"/>
        <property type="gene ID" value="GSCOC_T00035920001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVR8"/>
    <dbReference type="OMA" id="FHWSHAI"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVR8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000217">
        <property type="entry name" value="Peroxisomal membrane protein PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054154">
        <property type="entry name" value="PEX14-like_M_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23020">
        <property type="entry name" value="PEX14-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="17">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14 central plants" evidence="19">
        <location>
            <begin position="154"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="18">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="351"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="533" mass="58175" checksum="5037958B1059F07D" modified="2014-10-01" version="1">MASQSDSTPNSVDDKAQNPASQPSESTVNQGTVAKADVPNERATPSPFVNSEPIREEQVQNAVKFLSHPKVRGSPVMYRRSFLERKGLTKEEIDEAFRRVPDPTPSATASQPVVANQDGQLNSSSAIQQQVPTQTLQRAQAPSTGNISRLGLYQFHWSHVLYAIGFLAVSGAGTAVLLKKTIIPRLKSWIRKVVLKEEEGEPLVEKGNAKPNLAEEAAAAAKAAAAAAADVARTSQEMLMSKTEEKRYFSELTNLLDVQIREMKTMSNAVQKLQDKGESSIPGRIATREEDNHRVSVVNSRQPYSNGKVDNRIDSVISSSPSPSVEPSAAPHPKSYMEIMAMVQRGERPSNIREINDQPPNPSQPVPNPRLVPKPKPWEVGQSQSSSGSGFQYQESSNGFTSGSQTIQLNADGSVPWWQQKNARITEIESDDEQNIRSSVASEKPVQRSWVPPQPPPVAMAEAAAAIRQPKKPLLQKEQLTDDQLLGRASEVTDELQRITKISEAGGLEANGGNPANNASEIQREEEQAYTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYE2</accession>
    <name>A0A068UYE2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lipoxygenase</fullName>
            <ecNumber evidence="15">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00038212001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Lipid metabolism; oxylipin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="15"/>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYE2"/>
    <dbReference type="SMR" id="A0A068UYE2"/>
    <dbReference type="FunCoup" id="A0A068UYE2">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYE2"/>
    <dbReference type="Gramene" id="CDP13317">
        <property type="protein sequence ID" value="CDP13317"/>
        <property type="gene ID" value="GSCOC_T00038212001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYE2"/>
    <dbReference type="OMA" id="HWINDHE"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYE2"/>
    <dbReference type="UniPathway" id="UPA00382"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.245.10:FF:000002">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.375.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.375.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.372.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020833">
        <property type="entry name" value="LipOase_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001246">
        <property type="entry name" value="LipOase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027433">
        <property type="entry name" value="Lipoxygenase_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00468">
        <property type="entry name" value="PLTLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00711">
        <property type="entry name" value="LIPOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 15" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="17">
        <location>
            <begin position="116"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="18">
        <location>
            <begin position="243"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="939" mass="105724" checksum="F3A6E82815BD4546" modified="2014-10-01" version="1">MLHSPIDQKPFPAMFTAQPSPCTLSSSTIQHVPTVRRSETITGGGRRIGGFTRQKANNVPGFQSTVQSKHQPIRTVISSEGAKLVEKSQGSNGSLASSSVSGGMEVRAAVTIRRKMKENITDKLEDQWESFMNGIGRGILLQLISEDIDPITRSGKSAESYVRGFPKPSNHPFVVEYAANFRVPNDFGRPGAILITNFLDKEFYLVEIVVHNFSPEPQFFPANTWIHSRKDNPESRIIFKNQAYLPSQTPDGIKDLRREDLLSIRGNGKGERKMHERIYDYAPYNDLGNPDKSDELARPSLGGNEQPYPRRCRTGRRPTKKDPLSESRIEKPHPIYVPRDEAFEEIKQNTFSAGRLKALLHNLIPLISSTLSSSDNPFTCFSEIDKLYNDGVLLKDEDQKDVIKNQFLTNLMNQVFTVGGRLLKYEIPAVIKRDRFAWLRDNEFARQALAGVNPVNIELLKELPILSKLDPAVYGPPESAITRELIEQELFGMSVEKALEDKRLFILDYHDMLLPFIEGMNSLPGRKAYASRTIFFYTPTGILRPIIIELSLPPSSNSPRKKHVFVHGHDATTHWIWKQAKAHVCSNDAGIHQLVNHWLRTHACMEPYIIATHRQLSSMHPIYKLLHPHMRYTLEINALARQGLINGGGIIEACFSPGKYSMEISSAAYKSLWRFDTEALPADLVRRGMAVEDPSMPCGVKLAIEDYPYAADGLLIWSAIKELVASYVDHYYSDPSSITSDVELQAWWNEIKNKGHFDKRDETWWPNLGTKEDLSSILTIMIWVASGQHAAINFGQYPFGGYVPNRPTLMRKLIPGEGDPAYEKFLLNPVHTFLSSLPTQLQATKIMAVQDTLSTHSPDEEYLHQLHNVQSTSIKDPEVLKLFEKFSAKLEDIERTINERNRNIALKNRSGAGIPPYELLLPSSGPGVTGRGIPNSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYK8</accession>
    <name>A0A068UYK8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00037264001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739154">
        <property type="protein sequence ID" value="CDP12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYK8"/>
    <dbReference type="Gramene" id="CDP12678">
        <property type="protein sequence ID" value="CDP12678"/>
        <property type="gene ID" value="GSCOC_T00037264001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYK8"/>
    <dbReference type="PhylomeDB" id="A0A068UYK8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000079">
        <property type="entry name" value="Protein SRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="371" mass="41950" checksum="ED195528BDB8E389" modified="2014-10-01" version="1">MAKLHRACKDWGFFQLVNHGAATVIEKMKLVTEDFFKLPLQQKMACPQLPNDVEGYGQIFVVSEDQKFDWGDMIFLCALPVSQRNMRFWPTTPTSFRLQKPENCVQNIHHNANSQISDDVRATMDDPEKLCSIYQDGMQGIRMNYYPPCQQADKVIGQTSHSDAIGLTLLVQVNDVQGLQIKKSNTWVPIKPIPGEIIINIGDIMELMGSHEDKQVKESAHFHLQYYCFFFNLHHKPSLVNYQYAFMEVSSCMLLICLLFYVMVGCPTLICTCLDDIKPTLDEYSLELLEVCITLVKVMVTNLGVDGPEIINSMYPDVMQGMIMNQCPPCSQGDKVVCLIAPHSDGGLTLLVQVNKVEGLQIKKNNRCVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V032</accession>
    <name>A0A068V032_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00039204001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP14031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V032"/>
    <dbReference type="FunCoup" id="A0A068V032">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V032"/>
    <dbReference type="Gramene" id="CDP14031">
        <property type="protein sequence ID" value="CDP14031"/>
        <property type="gene ID" value="GSCOC_T00039204001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V032"/>
    <dbReference type="OMA" id="VFILFTD"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V032"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009627">
        <property type="term" value="P:systemic acquired resistance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="653"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP14031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="91817" checksum="06F7C7EB316A1387" modified="2014-10-01" version="1">MRFNFNFIGLDDSGDGLESLSSPSTSTPKEDVEWLPLQHHPIFTSAADGALPPSSSASSKTLTNLLAWDGASRLYFWDSQKQCLHRISVQLGEPDPSSILAASPSKVLQADVQLNYEVQKISINRHGSAMLLSGSDRLCVMYLYGKTSVKDNIVICRTVTIGAEIYFHRRSIIRMLQVYWHPSSDTHLGILSSDSVFRIFNLSMSLQQPEQEYYLQPVKFGSSTRASSICPVDFSFGGNHLWDRFSVFILFSDGSVYVLCPIIPFGSVYKREVLQEIYVDAKTVGLNSTNSKAVSNINMAISWLEAIFPELSQQSAEGGDSFALKARPYAFIDSSIVLQGPLRNFCHGEKKDTQVQDAEGQGRAVSFLYNLVSKDSVLVIAWSGGQLQIDAFADEIQPVWKAGSPPRLFVDSCDRILGIAMICESVSSDLSFPEPDPTLDRDVWMGHPPPLLRLAIVDLALPGKGGSHISMSVDPLMPERTYCFHNGGIDSVVLHFLPFSSQSDGKDGARRSPSVNPVISACHGESSSTSSLCGFLALADSFGDSWIVGVTYSRECIVLEMETWNLLLPPIVDEEKNPALEEEKQYTNSTTIISKELLSGPKVVLLPPSSPNLRSVTADSIEGRSTLHQYFKLFHENYMEYAYKVYFELQHHAPQLKKIIDNQHSRLQKAEQKLLEVEEKQEKLESRITNAVQHCNVLEERLLKLRNLPGIHKKPLSKAERDFKAELDRYNGVELDALRSSIEALDARLKRFENSQQANVLNQHTQVSGKRMNYIPAEEVSKLRSSIEKLSLVNNENTKMVKLIESALRNLEINSTQGGICRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V453</accession>
    <name>A0A068V453_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00043033001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V453"/>
    <dbReference type="FunCoup" id="A0A068V453">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V453"/>
    <dbReference type="Gramene" id="CDP15342">
        <property type="protein sequence ID" value="CDP15342"/>
        <property type="gene ID" value="GSCOC_T00043033001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V453"/>
    <dbReference type="OMA" id="HGHRMSG"/>
    <dbReference type="OrthoDB" id="781280at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V453"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009834">
        <property type="term" value="P:plant-type secondary cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655410" description="Protein kinase domain-containing protein" evidence="13">
        <location>
            <begin position="27"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="373"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP15342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="688" mass="74894" checksum="13A2AC47A3EDD925" modified="2014-10-01" version="1">MDLCPAFFSLLLLLLITHLSFFTTTASSNDTAALTLFRSQTDLHGTLLSNWTLPPASNAATTACTASWVGVKCTNGRVTALFLPSLNLRGPIDSLSSLDQLRLLDLHDNRLNGTLSPLIRCLNLKLLYLSGNDISGEIPPDISSLRRLLRLDLSNNNLRGPIPSQFSNFSRILTISLQNNALSGTIPKSLVSLQELKSLNLSNNEFYGAVPQDLLKRYGENSFAGNEGLCGTSPLPPCSFTGKQPPSSSQTVPSNPSSLPATTAATFPTEKSKTHSRKKLGSGALVAIIVSTAVAALVIASFLIAYCCGRYSRDGSSLAGSESGKRRSSYSGGERRVYANNGGADSDGTTATDKSALVFFDRRKQFELEELLRASAEMLGKGSLGTVYKAVLDDGCTVAVKRLKDANPCARKEFEQYMDVIGKLKHPNIVKLRAYYYAKEEKLLVCDYMPNGSLHSLLHGNRGPGRIPLDWTTRISLVLGAARGLAKIHQEYATSRIPHGNVKSSNVLLDKNGVACISDFGLSLLLNPVHAIARLGGYKAPEQAEIKRLSQKADVYSFGVLLLEVLTGKAPSQYPSPSRPRLEEDDEEQPVDLPKWVRSVVRDEWTAEVFDQELLRYKNIEEELVSMLHVAMACVVPQPEKRPTMAEVTKLIEEIRVEQSPLGEDYDESRNSLSPSLANTEDGGVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5E9</accession>
    <name>A0A068V5E9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00016796001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="7056" checksum="4CEFDD3A933B5108" modified="2014-10-01" version="1">MEERSRLEIQANKAASLHSDIMSIYYEKINAADDFEGRETALETKESQQIQQKLKAVKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6T0</accession>
    <name>A0A068V6T0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00018501001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739213">
        <property type="protein sequence ID" value="CDP16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6T0"/>
    <dbReference type="Gramene" id="CDP16510">
        <property type="protein sequence ID" value="CDP16510"/>
        <property type="gene ID" value="GSCOC_T00018501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6T0"/>
    <dbReference type="PhylomeDB" id="A0A068V6T0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="11">
        <location>
            <begin position="734"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1418" mass="163308" checksum="CF38609A9FDE31F5" modified="2014-10-01" version="1">MECFGKLVKKKNRKKAVKSKNRTSTDVFDSLFLELDDCTSFTFFTERSSAITDQVGIVRIEAELLGMFQMYMANWNNADKQRGAGQGLGSLVLEIEAAVEEATSDVRVAHQSAGRYEKIEIAIAKLQQKLMFFRPQMEVAYEYVASNHSFESQHPLNNYENWENFCDTLLGVVRRQRDLLCRLCSQLRTMYDMVKCLHRYVEGMQGTCPNLQRDLLTHFGGVLVRAAHFSYVCWIHRMDEDKDQGMIIMLSDLVKAFKPNTPQVSELCLKLTTGYCSCHSSISSPHYLVKAYIYFLIPKEYYRYETLRRSLKDLIFFVHSICVSDLYRNDNVKLTLMEIKATIIELGSFGYSFHDTEETRDTDPAFFRLVEKMELLRAEVFLIRLLNQRGSLKFLEHQIDSFHNELKYFRDYQRNAPVAETKVPKLIWLHIKPVAGEADSVCRSFLAESITEDKFTDELLKLLEKIKLLKTEVLFEELLSKHPSLIVNVKLQIKSLDQGLVVSRTYLMGPLEENEKLILAQVESVARDAACFYYSLLENEITEDTVRKFSHLLPGLVEKMKDVNAMIKEIYLPHRRLSRSNFPKLEGLGCIDFFLVDLFEQLKSKADSILSVKHQFHVVHEEIKFLRSFLAYIEEQYNEHQELKSVASCIIQVTLEAEYLIDLFVAGDCLRWYHPLWLSDLVEDLRIIKFQATETCKNVQGINIHNVLSTSTRASSPAESPQIDEAVIDLADEKKLVIDRLVAGAGKLDVVSIVGMAGLGKTTLAWKVYNDPSITYHFHVQAWCCVSQAYQKRELLLQILGDTVELTDDLLEMSDADLEMKLYRCLKRNKYLIVMDDIWSIEACWELLQKKLFGTEGCPDELLELGKQISRSCGGLPLALVAISGLLKRTDMEPDWWKQVSENICSRIADDPETRCMDILNLSYTYLPDYLKRCFLYTGVFLEDKDIPVRKLTWLWAAEGFIANTQLGSKEDVAERYLRDLIGRSLVMASKRRSDGGVKTCRVHDMLRTLCLRRCEEENFLQWQNGYDELFPPTYEDLDYGVDPGYCLPANSTTYENRRVSIFSKRKHFVMSSPCGPCVRSLLYSATSDMRPWCPYDISSILNNFKLLRVLDVECINMGHAFPRGIEVMVRLRYLALSGDIDSIPESISELLNLEILLVKGLKGRVLLPRTIWSMAKLRHVHVINHAAFSLQDGIWKSSSQLHNLVSFSSPYLSCGERTENIMRRLPKLRKLRCTFSELSDDNEKCNQFPKLNFLTELVSLKLLYSGRIALPCKFDFPLNLRKLTLSKFHLPWSYISEIGKLPNLEVLKLLSKAFEGEVWEMKEGEFLNLKFLKLDSLNLAEWNASSDHLPQLQHLILRSCRQLKEVPSGFGEICTLEMIEVQLCTRSVGKSVRRLQTESLDMGNELKVLIDRSEMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6W4</accession>
    <name>A0A068V6W4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00017273001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6W4"/>
    <dbReference type="Gramene" id="CDP16184">
        <property type="protein sequence ID" value="CDP16184"/>
        <property type="gene ID" value="GSCOC_T00017273001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6W4"/>
    <dbReference type="OMA" id="HHETIND"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6W4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39689" checksum="7D97D19C4C97F510" modified="2014-10-01" version="1">MFLSALSFSLASPCYVKLKAKSTLIVELLQVAVASYRKRHIELSTESSNTIYHHQKGSSILPSEKLRFLNKACIIVDPEKDLTTDGRAADPWTLCTINQVEDLKRLVKVIPLWSTGMIMSVNISQNSFPVLQANSMNRRFGSSFEIPAGSFGMFTIISIIIWIALYDRVFLPIVSKIMGKHVHLSARKRMAIGMLLSFVCMVVTATVEAKRRNLAIREGYSDDSETVLDMSALWLLPQLCLIGFAEALSAVAQNEFYYSEFPLSMKSIASTLFLLEMSVANLVASFLMNIIDKLSKRGGKESWISTNINNGHYDYYYWVLAGLSMLNMIYFLTCTKAYGPGKEDEKENSSWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V819</accession>
    <name>A0A068V819_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00005296001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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            <taxon>Coffea</taxon>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
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                <person name="Dussert S."/>
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            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP17062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="547" mass="60592" checksum="FEE94C4B290EAB4E" modified="2014-10-01" version="1">MEDLGGSRFDGLGIAVRKKRSQTSRRPRPEPHLFCENHDPSSLSSIPISDDTGKVSSDDNAGDADSRGKIFNLNQCMSRGPSTSKDDVDNMYKKIKEDEGGSDALHTIGGVGDGTDYGQAVARGCLGLSGDGIGNENKLKKVKLKVGGVTRTIQAKSTPNGILNNGISAKTARSLDPRARQRLILQDGADHPPLDQKSGLPGVPSKDFPRGRLSLGKMVAKNGIEKPGEKPDPVRKSRRVPKKRVLDGAFDEDEDDDELRYLEKIRIPKVAGHRDFDAESTKKQRNLLRVSKGEKYEILDEVGNSSKDGKRSRSDRGSEDTDYEEEMLSDVEPEAKKRKQRKDSFDSPPESKREITLTTRQRALLSSKDTSTTSGASQIEFPNGLPPPPPRKQKEKLTEVEQQVKKAEAAQRRRMQNEKAARESEAEAIRKILGQDSSRKKREDKMKKRQEELAQEKAANAQMLASNTIRWSMGPAGTVITFPHEMGLPKIFDPKPSRYPPPREKCAGPSCTNAYKYRDSRTKLPLCSLQCYKAINTEIQAKTACQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCG2</accession>
    <name>A0A068VCG2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00010779001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HD-ZIP homeobox family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739337">
        <property type="protein sequence ID" value="CDP18540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCG2"/>
    <dbReference type="FunCoup" id="A0A068VCG2">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCG2"/>
    <dbReference type="Gramene" id="CDP18540">
        <property type="protein sequence ID" value="CDP18540"/>
        <property type="gene ID" value="GSCOC_T00010779001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCG2"/>
    <dbReference type="OMA" id="QAPVMGC"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCG2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08875">
        <property type="entry name" value="START_ArGLABRA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000229">
        <property type="entry name" value="Homeobox-leucine zipper protein HDG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042160">
        <property type="entry name" value="HD-Zip_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057993">
        <property type="entry name" value="HD-Zip_IV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654:SF11">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HDG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN MERISTEM L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25797">
        <property type="entry name" value="PDF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="14">
        <location>
            <begin position="277"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP18540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="90454" checksum="AF0DBB7682AED223" modified="2014-10-01" version="1">MFGDCQILSSMGGNGVPSDSYYPSSIQNPSFSFMTNLPFNIFPPALIPKEENGMSRSKEEILESGSGSEHVEGGVSGNEQEAEQQQPTKKKRYHRHTARQIQEMEALFKECPHPDDKQRLKLSQDLGLKPRQVKFWFQNRRTQMKAQQDRADNVILRAENESLKNENYRLQAALRNVVCPNCGGPAVLGEMGFDEQAVRLENARLKEEYDRVCALLSQYGGRAIPEIGTSSLLAPSLDLDINMLPRKFEEPIGDCPGMLSMPFIPENPNFSGGVLILDEEKSIAMELAISSVEELMKMCQACEPLWLRTSDGSKEVLNVDEYRRLFQWGVDLKQNPTQVRTEATRHNAVVIMNSITLVDAFLDANKWMELFPSIVSRAKTLQVVTSGVSGHASGSLQLMYAELQVPSPLVPTRESHFLRYCHQNAEGGTWAIVDFPLDNFNNSYPTIPYYKRRPSGCIIQDMPNGYSRVTWVEHVEIDSTPLNQTINHLVSSGNVFGAKRWLSVLQRQCERIASLMARNISDLGVIPSPEARKNVMYLSQRMIRTFCMNISNACGQSWTALSDSAEDTVRIATRKVSGPGEPNGLILTAVSTTWLPYPHYQVFDLLRDERRRSQLDVLSNGNALQEVAHIANGSHPGNCVSLLRINASPTVASNSSQKVELMLQESCTDDSGSLIVYTTVDVDSIQLAMNGEDPECIPLLPVGFVIHPLEIGSSSHDGSSLDNDQTSENGNNLPADLSGCLLTVGLQVLASTIPTAKLNLSSVTAINQHICNTVQQISAALGNHGSNIGTTSSNDNDNIIIASLGEPSAPAPPVQPDQVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD09</accession>
    <name>A0A068VD09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00011065001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739252">
        <property type="protein sequence ID" value="CDP17573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD09"/>
    <dbReference type="Gramene" id="CDP17573">
        <property type="protein sequence ID" value="CDP17573"/>
        <property type="gene ID" value="GSCOC_T00011065001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD09"/>
    <dbReference type="OMA" id="MENIMDP"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VD09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03480">
        <property type="entry name" value="Rieske_RO_Alpha_PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP17573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="24539" checksum="B8D051D6ADB97D9A" modified="2014-10-01" version="1">MPAADQSSKDASFDQQTDTSEKEEKFDWYAQWYPVIPVCDLDKRRPLGKKVMGIDIVVWWDRNENEWKVFDDTCPHRLAPLSEGRIDQWGRWQCVYHGWCFGGSGDCKFIPQAPRDGPPIHTSSKACVAAYPSCVLNGILWFWPNADSQYKDIFSKEKPPYIPEIDDPSFTSRMITRDIPYGYEILIENLMDPSHVPYAHYGILKVPRSSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDD7</accession>
    <name>A0A068VDD7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00005863001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739378">
        <property type="protein sequence ID" value="CDP18855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDD7"/>
    <dbReference type="FunCoup" id="A0A068VDD7">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDD7"/>
    <dbReference type="Gramene" id="CDP18855">
        <property type="protein sequence ID" value="CDP18855"/>
        <property type="gene ID" value="GSCOC_T00005863001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDD7"/>
    <dbReference type="OMA" id="GANLMHE"/>
    <dbReference type="OrthoDB" id="674745at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDD7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46442">
        <property type="entry name" value="DIRIGENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46442:SF6">
        <property type="entry name" value="DIRIGENT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008190205" description="Dirigent protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP18855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="177" mass="20352" checksum="64077C6B658C1FD4" modified="2014-10-01" version="1">MQKYICIVLLLLAFPFIFSHAKRTNPDKPCKHFTVYYHTVIFNGTNTANATAAVVREPTKFWNTSFGQMVIFDSPLTKDQSLLSTPIGRAQGLYFYDMKMRVGSWFAYSLLFNSTEHKGIINIMGANLMHEETRDLSIVGGTGDFFMARGIVTLRTEDVDIPRYFRLQMDVKLYECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VER0</accession>
    <name>A0A068VER0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00002112001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739428">
        <property type="protein sequence ID" value="CDP19087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VER0"/>
    <dbReference type="FunCoup" id="A0A068VER0">
        <property type="interactions" value="1208"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VER0"/>
    <dbReference type="Gramene" id="CDP19087">
        <property type="protein sequence ID" value="CDP19087"/>
        <property type="gene ID" value="GSCOC_T00002112001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VER0"/>
    <dbReference type="OMA" id="FSHVWRT"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VER0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901259">
        <property type="term" value="P:chloroplast rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="623"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="697" mass="78630" checksum="CA33E43A328B71F3" modified="2014-10-01" version="1">MEKLILSTTAFPSFQRKPSLLSTLVPSDATVKLAAATIPITSTKTKSPSHFGLLLHRSCCVNPYKGNNAVGVRTLHHDHDVDDSNDKDDAEVAGDHQLQKEDSASTDWEVKFLGQMGPFQNLPSEKRKEQQKSRLLQDTDKMDWCVRARKIALKSIENRGLTSVLKNSVNGNKKKRKKNKKKSKVEDVVIKELDDDSDFDIHEGDFNNVADLHSSDDTSDLREMVSMMADGMFQERKDKTMETFIQRISQFSGPSDHRKEINLNKLIVEAQTAEQVLEVTADMIMAVVKGLSPSPLSPLNIATALHRIAKNMEKVSMTRARRLALARHKEMSMLVGIAMTALPECSAQGISNIAWALSKIGGELLYLSEMDKLAEVALTKVGEFNSQNVANIAGAFASMRHSSPELFLGLARRASEIIDLFQPQEIAQLLWAFASLFEPADLLLDSLDHVFNNINQFKYSMDVVTKNASLETGREVNGEATSESNLCSPVLSFNRDQLGNISWSYSVFGQMERVFFNHVWRTLSQLEEQKISEQYREGVVFASQIHLVNLCLKHEFPHLQLSLKSDLEEKVARAGRTKRFNQKTTSSFQMEVARLLVSTGLDWVKEYEMEGYTLDAVLVDIKVALEIDGPTHFSRNSGVPLGHTMLKRRYIAAAGWKLVSVPHQEWEELQGEFEQLDYLRRILDDHICKEREHHSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHM3</accession>
    <name>A0A068VHM3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00009022001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739446">
        <property type="protein sequence ID" value="CDP19168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHM3"/>
    <dbReference type="STRING" id="49390.A0A068VHM3"/>
    <dbReference type="Gramene" id="CDP19168">
        <property type="protein sequence ID" value="CDP19168"/>
        <property type="gene ID" value="GSCOC_T00009022001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHM3"/>
    <dbReference type="OMA" id="NSIVYAC"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHM3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP19168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="203" mass="22518" checksum="3E998B6F1F34701C" modified="2014-10-01" version="1">MTVNSSFPWLMVISRSLKENGLSNLVKVVLTPTHLAIVMEYAAGGELFAKICSAGGFNEDEARFFFQQLISGVSYCHSMEICHRDLKLENTLLDGSPTPRLKICDFGYSKSGLLHSQPKSVVGTPAYIAPEVLSRNVKIADVWSYGVTLYVMLVGAYHIDLIGFLLSMTIHSNSIVYACNGIFLTEIDSNAYDTFLSMQYKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIY1</accession>
    <name>A0A068VIY1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012620001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740764">
        <property type="protein sequence ID" value="CDP20750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIY1"/>
    <dbReference type="STRING" id="49390.A0A068VIY1"/>
    <dbReference type="Gramene" id="CDP20750">
        <property type="protein sequence ID" value="CDP20750"/>
        <property type="gene ID" value="GSCOC_T00012620001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="123" mass="13632" checksum="9CCBF3D833EF5686" modified="2014-10-01" version="1">MIGVVTAFHCALSPLKCWSSSFFCLFGALRGSDTFSIYPIFSSLLPSIPFSIFSSLFFSIGLDTSSVCSLLLHRHTVSLSSISSFSAQHHKIPFFDQPWDSPSASLRFKFILAGSPLSHWEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ93</accession>
    <name>A0A068VJ93_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DH200=94 genomic scaffold, scaffold_638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00010584001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739722">
        <property type="protein sequence ID" value="CDP19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ93"/>
    <dbReference type="Gramene" id="CDP19728">
        <property type="protein sequence ID" value="CDP19728"/>
        <property type="gene ID" value="GSCOC_T00010584001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ93"/>
    <dbReference type="OMA" id="INIHNWI"/>
    <dbReference type="PhylomeDB" id="A0A068VJ93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="12">
        <location>
            <begin position="394"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="13">
        <location>
            <begin position="651"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1099" mass="126886" checksum="5C239A6736901FB7" modified="2014-10-01" version="1">MKLTLIEIKATISELGSFSHSFHVTEETWDADPAFFRLLEKMELLRVEVFLINLLYQRTNLKILDGYIDSFDMEPTYLQSYQRDASKGESEVHKLTWLYSEEASSIYRSFHDKSITEDKYRDEPFKLLDKIKLLKLEILMEELLNRQPRLIVNVKDQIESIDQGLRLSRTYSVGLLEENEKLILAQAAAAASSFYYSLRENEITEDAVRKFSHLLPALVEKMNVLNAQFKEIYLSHRRSLRSNLPKMEGIGCIDFFLVDLLEQLKSKADSVLSMKQQFHVVHEEIKFMRSFLTDIEEQYNEHQDLKTVASRIIQVTLEAEYLIDLVVAGDHLRWYHQLWLSDLVEDVKLIKLQARDTYKNAHGINIHNVPTSSMMVSSPAELPKIDEVVIDLADEKKKVIDRLKVGSGKLDVVSVVGMAGLGKTTLVRRVYKDPSVTHHFHVRAWCCVSQAYQKRELLLQILGDIMKLTDDMLEMTDEDLEMKLYKCLKRNRYLIVMDDMWSIEAWYDLEQSFPNDKNGSRILITSRHSEVAAKVQVDSTPHPLRLLSDDESWKLLQKKLFDTKDCPNELMEAGKQIAESCKGLPLAVVAIAGLLERTDKTPDIWKQVSESICSRIADDPEMRCMDILELSYRYLPTHLKPCFLYTAIVLEDKDIPVRKLTWLWRAEGFITDTGVESIEDIAEGYLRDLIERSLVMPSKRRSHGGMKTCHVHDMLRTLCIRKSEEENLLQFQNEPSNSSHEDIDYGRNHFIMSRPSGPYVRSLLYSATSDSYPTCPYDISFIFENFKLLRVLDLECINMGYSFPTGVLVLVGLRYLALCGDIDSIPASITHLQNLETLLVKGLKGRILLPYAIWNMEKLRHLHVKNYATITLQDGESTIFPEVLNLVSLSSPYLLYGIGIENIMRRLVKLRKLRCLFSELRDDTGKCNQFPIMNFLTELESLNVLYSGRVGLPCKFDFPLNLRKLTLSKFRLPWDCISDIGRLPNLEVLKLLSKAFDGKVWEMKEGEFLKLKFLKLDSLNLSEWNASSDHLPQLQHLILQSCWQLKEVPPGFGDSFTLEIIEVQMCTSSLEESVKRLEEEQQEMGNELKVLVDHSDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJX6</accession>
    <name>A0A068VJX6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH200=94 genomic scaffold, scaffold_2497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00007284001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741581">
        <property type="protein sequence ID" value="CDP21105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJX6"/>
    <dbReference type="STRING" id="49390.A0A068VJX6"/>
    <dbReference type="Gramene" id="CDP21105">
        <property type="protein sequence ID" value="CDP21105"/>
        <property type="gene ID" value="GSCOC_T00007284001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJX6"/>
    <dbReference type="OMA" id="NKQFCLH"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJX6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052088">
        <property type="entry name" value="E3_ubiquitin-ligase_SINA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315">
        <property type="entry name" value="E3 UBIQUITIN PROTEIN LIGASE SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315:SF118">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Seven-in-absentia protein TRAF-like" evidence="5">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP21105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="115" mass="13263" checksum="F2B933CCCC1F546D" modified="2014-10-01" version="1">MSSFLVCTGFNCVGHQFCLHFEPFHPRTAPVYMAFLRFMVSDEDAEKFCYSLEVGGKGRKLTWQGVPRSIRDSHITVRDGMDGLIIYRNMALYFSGGNMKELKLKVSGRLWRKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKC4</accession>
    <name>A0A068VKC4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2909</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00000474001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741993">
        <property type="protein sequence ID" value="CDP21235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKC4"/>
    <dbReference type="STRING" id="49390.A0A068VKC4"/>
    <dbReference type="Gramene" id="CDP21235">
        <property type="protein sequence ID" value="CDP21235"/>
        <property type="gene ID" value="GSCOC_T00000474001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKC4"/>
    <dbReference type="OMA" id="ANADMLT"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF88">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="161" mass="17997" checksum="92E0082AD5262A03" modified="2014-10-01" version="1">MNEMKKAELVFIPSPGMGHLVSSVELAKLLIEREEQLSITVLIMKLPFDTNIISYRNSLSASLSSRIRFLELIKEEPSSQLTFSHSFLFQFIDSHKSCVKEVLAEISNSVSSDLSGIVIDMFCTSFIDVANEFGVSCYIFYTSGAAMLGLVFHLQSLRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL90</accession>
    <name>A0A068VL90_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-glucuronate 4-epimerase</fullName>
            <ecNumber evidence="10">5.1.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00011934001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate</text>
            <dbReference type="Rhea" id="RHEA:11404"/>
            <dbReference type="ChEBI" id="CHEBI:57635"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="5.1.3.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.6" evidence="10"/>
    <dbReference type="EMBL" id="HG742659">
        <property type="protein sequence ID" value="CDP21367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL90"/>
    <dbReference type="FunCoup" id="A0A068VL90">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VL90"/>
    <dbReference type="Gramene" id="CDP21367">
        <property type="protein sequence ID" value="CDP21367"/>
        <property type="gene ID" value="GSCOC_T00011934001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL90"/>
    <dbReference type="OMA" id="HNMNRQF"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VL90"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050378">
        <property type="term" value="F:UDP-glucuronate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000198">
        <property type="entry name" value="UDP-glucuronate 4-epimerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="94"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP21367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="433" mass="47959" checksum="F9EE08E8C0D8B93D" modified="2014-10-01" version="1">MPSLEEELFPSTPGKFKDRGGAHSMNRQFYRCFASTSTMFLWALFLIALTASYLSFQSFVDSGSRYFSSAWGGHHWEKQVKSSAQIHRANGFSVLVTGAAGFVGSHVSLALKKRGDGVVGFDNFNNYYDPLLKKARKALLNSHNVFIVEGDVNDAKLIAKLFDIVEFTHVMHLAAQAGVRYAMENPHSYVHSNIAGLVTLLEACKNADPQPAIVWASSSSVYGLNEDVPFSESDRTDRPASLYAATKKSGEAITHTYNHIYGLSITGLRFFTVYGPWGRPDMAYFSFTKGILQGKPITIYRGKNRVDLARDFTYIDDVVKGCVASLDTAKKSTGSGGKKRGPAQYRIFNLGNTSPVTVPMMVGILERHLKVKAKKNYVDMPGNGDVPFTHANISLARRELGYKPTTDLQTGLKKFVKWYLAYYGHNHGKSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VM57</accession>
    <name>A0A068VM57_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_5623</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00001095001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG744707">
        <property type="protein sequence ID" value="CDP21674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VM57"/>
    <dbReference type="FunCoup" id="A0A068VM57">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP21674">
        <property type="protein sequence ID" value="CDP21674"/>
        <property type="gene ID" value="GSCOC_T00001095001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VM57"/>
    <dbReference type="OMA" id="YTIMFSD"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VM57"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22814">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22814:SF84">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP21674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="148" mass="16256" checksum="6125178CA833E1DE" modified="2014-10-01" version="1">MGVAGTLEYLADLISSRTAKKKKITNTVALKVRMDCEGCARKVKKALKGVKGAKKVDVDLKQQKATVTGFVDAKKVLEAARATKKKVEPWPYVPYTLIAHPYAAGVYDKKAPPNFVRKTDEPGVATLNPVEEQFLMFNDENPNACSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMU5</accession>
    <name>A0A068VMU5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00005165001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG749036">
        <property type="protein sequence ID" value="CDP22085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMU5"/>
    <dbReference type="STRING" id="49390.A0A068VMU5"/>
    <dbReference type="Gramene" id="CDP22085">
        <property type="protein sequence ID" value="CDP22085"/>
        <property type="gene ID" value="GSCOC_T00005165001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMU5"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="9">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP22085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="115" mass="12957" checksum="173AD30855802ADF" modified="2014-10-01" version="1" fragment="single">MFSTPSQAFDYADALSKSLLCFEGQRSGRLPYNQRVSWRHHSGLTDGLGQGVDLVGGYYDAGDHVKFGLPMAFTFHIDKEMGCYNVLMGCYREMEHALEAIKWGADYFTLDLMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VND7</accession>
    <name>A0A068VND7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2797</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008130001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741881">
        <property type="protein sequence ID" value="CDP21208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VND7"/>
    <dbReference type="Gramene" id="CDP21208">
        <property type="protein sequence ID" value="CDP21208"/>
        <property type="gene ID" value="GSCOC_T00008130001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VND7"/>
    <dbReference type="OMA" id="ENMAFRN"/>
    <dbReference type="OrthoDB" id="1164832at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VND7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF30">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="2">
        <location>
            <begin position="57"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="424" mass="48746" checksum="6DBE29E8F7B44D5B" modified="2014-10-01" version="1">MHDIVHDFAQFLTKNECHALDGTGRNSSSERPRHLTILEEGTEEEMFSSPVVDFGRLRSFLTFQRVVVPQNLFCSLKCARTLTLHYCRLAEIPAEIGRLIHLRHLNLSANRFITLPEAICDLYYLETLDISDCYELSCLPQRIEGLVHLRHLFNSCTYQLRQIPQGLGKLMSLCSLTRFIARSNSDDLAILKDLNQLESLRVEIEGEVDFGSAELEKKVNMREMSLFFSFGVHFIETPSYIESMEPPPKLERLVLGGYPGVQLPSWLVTKSHANNLTRLIISGPSNISSLPALWKLSSLRELEFVRVGKLEYLGKEFFGVTKALHENMAFRNLRKLHFEDCDNWTRWEDTSEDDEEVAVSIMPSLEKLKIRGCDKLETLPHRILGRISSLKKLNIWGCSKLRDRYSDKTGDDWKQISHIPQVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNF4</accession>
    <name>A0A068VNF4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_10998</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013454001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG750082">
        <property type="protein sequence ID" value="CDP22139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNF4"/>
    <dbReference type="STRING" id="49390.A0A068VNF4"/>
    <dbReference type="Gramene" id="CDP22139">
        <property type="protein sequence ID" value="CDP22139"/>
        <property type="gene ID" value="GSCOC_T00013454001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNF4"/>
    <dbReference type="OMA" id="LVECHRR"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNF4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF270">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE HPR3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="2">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="156" mass="17297" checksum="CEBB9410F629C9EA" modified="2014-10-01" version="1">MFGKCPVSTIRLLFLLSSFNPQLKRLMAQIHTNQIELSVNLPQVLVLGPPSIFPIYEKHFSLKFMLLKPWESPIPLEEFLSIHSQNTTAVLTSSAVAYLSSALRLLPSVRLVVTSSVGLDHIDLKECRRRGISVAYAPSVLSADVADLAVGLWVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNH2</accession>
    <name>A0A068VNH2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_12290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00006432001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG751374">
        <property type="protein sequence ID" value="CDP22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNH2"/>
    <dbReference type="STRING" id="49390.A0A068VNH2"/>
    <dbReference type="Gramene" id="CDP22216">
        <property type="protein sequence ID" value="CDP22216"/>
        <property type="gene ID" value="GSCOC_T00006432001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNH2"/>
    <dbReference type="OMA" id="EWILALM"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF154">
        <property type="entry name" value="ABC TRANSPORTER A FAMILY MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="278" mass="31074" checksum="6B15C30E66FFD37E" modified="2014-10-01" version="1" fragment="single">MILLELQVAPFAMTHVAYLSTFSYSDFGITYQLLPKEGVWLIVLELFPALSLYRGLDELFNFSEAAFEMGAYGMRWQSLRDENSGMREVLIIMSIEWLVFLFMSYCTLGGCFCRSPLSIFRSTQERPPSFQSPRLQVQESGVLVHVDNQDINQEVHYIHKCVPMAVAFLCAFLFGFSLIIQETILKVEHLLNEPSTSYPIISHKLQKTYPARDGNPEKQAVRGLSLAVARGECFGLLGPNGAGKTSFISMMTGLTKPSSGTAYVGGLNLKTQMSEIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNR4</accession>
    <name>A0A068VNR4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_12368</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00002541001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG751452">
        <property type="protein sequence ID" value="CDP22219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNR4"/>
    <dbReference type="Gramene" id="CDP22219">
        <property type="protein sequence ID" value="CDP22219"/>
        <property type="gene ID" value="GSCOC_T00002541001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNR4"/>
    <dbReference type="OrthoDB" id="1938319at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF32">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP22219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="316" mass="34734" checksum="B16ECEE682E9D852" modified="2014-10-01" version="1" fragment="single">MGLTGTIPRLLGNLSFLVTLDLSGNKFQGSLPQEIVYLHRLRVINLSFNNFTGQIPSWFSFLTCLKYLNLKKNNFTRLIPHSLFNLLKLENLILSSNSIQGIIPEEIGNLHSLKYVDIETNQLNDSIPSSVFNISTPETIALGHSPFGNLPTDVCLNLTKLKKLSLSSNKLSGQIPSSLSRFHCIFTGSIPKAVGALCNLNIPSSTGDHKSTRKKTSHVIFITSGIGAALMAITLTIVFLMYRNKTEVGRTEGILEIRTVQRISYYELLQATHGYEESNLLGTGSCGSVYKGILKDGMLVAVKMLNLQVKISLGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VPM8</accession>
    <name>A0A068VPM8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RHOMBOID-like protein</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00007323001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="HG744601">
        <property type="protein sequence ID" value="CDP21663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VPM8"/>
    <dbReference type="STRING" id="49390.A0A068VPM8"/>
    <dbReference type="Gramene" id="CDP21663">
        <property type="protein sequence ID" value="CDP21663"/>
        <property type="gene ID" value="GSCOC_T00007323001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VPM8"/>
    <dbReference type="OMA" id="TETFCED"/>
    <dbReference type="OrthoDB" id="1711561at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VPM8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP21663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="134" mass="14903" checksum="833C9B63972B30A0" modified="2014-10-01" version="1">MLSELLTNWTIYSNKVAALFTLVVIIVINLALGILPHVDNFAHIGGFISGFLLGFVLLFRPQFGYLESRQIPPGARLKSKYAVYPVLMLVALVLLIIGFTVGLVMLFRGENGNDHCSWCHYLSCVPTSKWSCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKN2</accession>
    <name>A0A068TKN2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014019001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKN2"/>
    <dbReference type="FunCoup" id="A0A068TKN2">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TKN2"/>
    <dbReference type="Gramene" id="CDO96860">
        <property type="protein sequence ID" value="CDO96860"/>
        <property type="gene ID" value="GSCOC_T00014019001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKN2"/>
    <dbReference type="OMA" id="AYVELQM"/>
    <dbReference type="OrthoDB" id="1915848at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKN2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009959">
        <property type="term" value="P:negative gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006943">
        <property type="entry name" value="DUF641_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040225">
        <property type="entry name" value="GIL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056813">
        <property type="entry name" value="GIL1_IRKI_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31161">
        <property type="entry name" value="PROTEIN GRAVITROPIC IN THE LIGHT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04859">
        <property type="entry name" value="DUF641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24994">
        <property type="entry name" value="GIL1_IRKI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF641" evidence="2">
        <location>
            <begin position="68"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GIL1/IRKI C-terminal" evidence="3">
        <location>
            <begin position="396"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO96860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="457" mass="52061" checksum="8AE4C827E7FD8981" modified="2014-10-01" version="1">MDSIRPSPAPSKNKLAKKFQKVIHLKTATKNRSNNAFCLLIPQEKLKCCESQQFEKEEIEDAAKESKNRAAMEAFIAKLFATVSSVKAAYAEIQMAQFPYNGEAIQSADQAVIDELKALSELKHSFLKKQIDASPPHVTLMLAEIQEQQSLMKTYEITMKKMQNEIEGKEAQISSLQRELNEAIQNNKSLEKKINASGSFSILDNVKFSEANSKDFIMVLHYALRSIRNFVKLMIKEMVSANWDVEAAANSIQPEVNFVKKDHKGFAFESFVCREIFSGFNDPGFAVRHENQPWPNGGYQKRLFFFDQFKKVKSVSVLQFLKHNPNSFLGKFLKSKYLQLIHPKMEFSFSGNLNQRKLVNSGEYPETEFFKAFAEMGRRVWLLHCLAFSFDHEVSIFQVKKNCRFSEVYMESVTDDIFTAADGDFRVVFTVVPGFKVGQTVVQSQVYLSPARSAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLF1</accession>
    <name>A0A068TLF1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BURP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014292001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLF1"/>
    <dbReference type="STRING" id="49390.A0A068TLF1"/>
    <dbReference type="Gramene" id="CDO97066">
        <property type="protein sequence ID" value="CDO97066"/>
        <property type="gene ID" value="GSCOC_T00014292001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLF1"/>
    <dbReference type="PhylomeDB" id="A0A068TLF1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF32">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01045">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654093" description="BURP domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="BURP" evidence="3">
        <location>
            <begin position="123"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="309" mass="34553" checksum="FB96AC4ACDB45FDB" modified="2014-10-01" version="1">MYMDLGSFACRIGHLFSLLILLGVHLQQGRPTEVHGEKWNKLTVSHDQNDASKQMDMHFSIVDSTTPKDPNVLRLHSMDVDDQEHNKKDDAQERETRTRDAQPHAHTSSHMMMNHMDLSTTVFFLLDDLKLGKTMPIYFPDRDLTSSSSPPLLSETEADDIPFSSQQLPNLLRLFSFSPGSPQAIAMEDTLRQCEIAPIKGDTKFCATSYESMINFAREILGSEANIQVLSTIHLTRSVAGSESRVYEVSLYGENGERVEAIAVCHLDTSRWSPNHVSFRVLGIKPGTSPVCHFFPADNFVLVASTSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLV4</accession>
    <name>A0A068TLV4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta-galactosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00014105001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 11"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLV4"/>
    <dbReference type="FunCoup" id="A0A068TLV4">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLV4"/>
    <dbReference type="Gramene" id="CDO96919">
        <property type="protein sequence ID" value="CDO96919"/>
        <property type="gene ID" value="GSCOC_T00014105001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLV4"/>
    <dbReference type="OMA" id="FEYHIPR"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLV4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22842">
        <property type="entry name" value="Gal_Rha_Lectin_BGal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000050">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000006">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041392">
        <property type="entry name" value="GHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17834">
        <property type="entry name" value="GHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0052">Apoplast</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654088" description="Beta-galactosidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="14">
        <location>
            <begin position="753"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO96919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="842" mass="94304" checksum="20079621A45CE5DC" modified="2014-10-01" version="1">MAHQHYRILVLALLLLLASSAAGVGRKKKTVTYDSRSIIIDGSRELLFSGSIHYPRSPPEMWPELIQQAKEGGLNVIQTYVFWNLHEPVQGQFNFDGNNDIVKFIKMIGEQGLYVTLRVGPYIEAEWNAGGFPYWLREVPNITFRSYNEPFMHHMQRYTDTIIDLMKKNKLFAPQGGPIIMAQIENEYNNVQLAYRDLGKKYVDWAANMAVSLYDQVPWVMCKQKDAPPTVISTCNGRHCGETFRGSNGPNKPTLWTENWTAQYRTFGDPPAQRAAEDIAFAVALFFARNGTLNNYYMYHGGTNFGRTSSSFVTTRYYDEAPLDEYGLPREPKFGHLRDLHRALRLSKKALLWGTPSVQQIEQDLQVITYDNPNVQNVCAAFLINNRTTTPATISFRGVDYYLPAKSISILPDCKTVVYNTVTIASQHNSRNFEESSKVGVLDWEFFPESIPSMDQLSQESKAPLELYGLTKDTSDYAWYRTSIHFDKRDLPMKAGVLPVLQALSLGHALLAFVNGEYIGFQHGNNIEKSFVFQKPISLKPGVNEISLLGMTVGFPNSGAYMEKRFAGPRVVTLQGLMSGTLDITMNNWKHQVGLNGERLQYFTEEGSSKVGWKKLNAAGNLGGVNAPLTWYKTYFDAPEGNGPVAIQMDKMAKGMIWVNGRNIGRYWVSFLSPLGQPTQSEYHIPRAFLKQTKNLLVVLEETGGDPREIKLVTVNRDTICSFITEYHPPQVKSWVRTGDQMRAVVENITSGAHLNCPGNKVIKAIEFASFGDPYGVCGTFAIGECNAPNALQIAEQYCKGKKECTIPMDKGLFFGANDACPHIAKTLAVQARCGNPGNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNU0</accession>
    <name>A0A068TNU0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4408 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00014243001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNU0"/>
    <dbReference type="FunCoup" id="A0A068TNU0">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNU0"/>
    <dbReference type="Gramene" id="CDO97028">
        <property type="protein sequence ID" value="CDO97028"/>
        <property type="gene ID" value="GSCOC_T00014243001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNU0"/>
    <dbReference type="OMA" id="GYRRCET"/>
    <dbReference type="OrthoDB" id="1095087at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNU0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33640:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29147" checksum="992FE6D48F82AC8E" modified="2014-10-01" version="1">MDSFHFHKIKMEKANAKLRHRRLHKITAMFRLMEFCILLIIVSRFTVQLPVAFKLSGEYFRGFSVTAVSPGLVFILGNAIVLVLFLKSGHPSAKNGDTTVNSKLDLYDEYVKINSEKNPSVYKEENTACKKQRKQSGSTCVGREVAVSSDAHNSRSDNTKERKVKIQRSQSENLKRAVQQQQQECAGRELRRLATVKCRGHVDNEEKPAVLGSSYKEDEMSNEEFRRTVEAFIARQQRALREEEEFAQCFLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPF1</accession>
    <name>A0A068TPF1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00014486001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPF1"/>
    <dbReference type="FunCoup" id="A0A068TPF1">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO97218">
        <property type="protein sequence ID" value="CDO97218"/>
        <property type="gene ID" value="GSCOC_T00014486001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPF1"/>
    <dbReference type="OMA" id="PYQPPEW"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPF1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000722">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF47">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654081" description="Protein kinase domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="475"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO97218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="759" mass="83017" checksum="AD8FE0F145E7B2C1" modified="2014-10-01" version="1">MLWCFSTLFLRLLLPSLALNVDGTLLLSFKYSILNDPLSVLDDWNYDDETPCLWTGVTCAQVETPFGTPAMFRVISLVLPNSKLLGSIPEDLGFIQHLRTLDLSGNFLNGTLPNSLFNASELQVLSLSSNAITGGLPGFSGGLKNLKLLNLSDNALAGNLPPNLPSLQELTVVSLKRNFFSGTIPNGFLYVEVLDLSMNLLNGSLPLEFGGERLRYLNLSTNKLSGPVSPEFAKKIPANATIDLSFNNLTGEIPESMALSNQQTESFRGNMDLCGKPLKKLCTVPSSLSAPPNISTTNSSAPAIAAIPQTIDSTPLPSSPGTAANAAQNQGQHRLKPGTIAGIAIGDLAGIGVLAIICLYVYQLRKRRADEGSKEIPLPVAVDKQQKDNVKDSQLSTAKETTSRSLPSWSCLTIRNGEEPSEATTSDCDDENKNMDIGHQIDQYHEKGRSTKYKSERSLVMVDGETELHIETLLKASAYILGSSAAASIVYKAVLEDGSAFAVRRIGESGFERFKDFESQVKAIAKLRHPNLVLLRGFYWGDDEKLVIYDYISNGSLANAGYRKVGSSPYHMPFQVRLKVAKGVARGLAYVHEKRHVHGNIKPSNVLLTPEMEPIISDFGLHWLLHGKNSYKTDAFSSRHFGFMGCTSPYHAPESLNNLKPNPKWDAYSFGILLLELLTGKVFSDRELGQWTAGLLMEDKNRVLRLADVAIRGDVANREDAMLECFKLGFSCASLNPQKRPSMKDALQVLDRIQTSPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQB5</accession>
    <name>A0A068TQB5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022553001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQB5"/>
    <dbReference type="STRING" id="49390.A0A068TQB5"/>
    <dbReference type="Gramene" id="CDO98456">
        <property type="protein sequence ID" value="CDO98456"/>
        <property type="gene ID" value="GSCOC_T00022553001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQB5"/>
    <dbReference type="OMA" id="DSTHRCH"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQB5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000031">
        <property type="entry name" value="Aspartyl protease AED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF274">
        <property type="entry name" value="PROTEIN ASPARTIC PROTEASE IN GUARD CELL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="136"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="482" mass="52040" checksum="B49B0658B462DA33" modified="2014-10-01" version="1">MYMARKAQRPCPSVNIFIIVLSFFSFTLSPFSPQVVSASAFKRLQLFSTEEAQPSSTSSVLSLSLHPRSSIMKLPYDNYSDLVLSRLASDRARAKLINSNIERAVSTFNCLHAVKPDVQVQPEDLKTPLTHSEGGYLARIGVGQPVKEFHLIADTGSQITWLQCLPCDPCYEQSDPIFDPSGSSSFSPLSCASQECTSLEKNQNCKADPCTYKASYGDNFSSMGEFATETVSFGSSGSVDKVAIGCGHTNQGGFGGAAGILGLGGTPVGFPSQIRATSFSYCLVDMDSNSSSSLEFNSAPPGDSVLVPLIINPRIEAYYYVELTGVTINGEKVSIPASDYQIGEDGRGGILVDSGTAITEFPTQVYYSVRDTFVKYARALPPASGFDYGPVKLDTCYDLSSEPTDCYPTMSFEFHGGKTLSLRPANYLIRVDTSGKHCLAFTGSSERVSSKRVSIIGNIQQQGMRVTYDITNKVIGFSPNQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRC7</accession>
    <name>A0A068TRC7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00022623001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRC7"/>
    <dbReference type="FunCoup" id="A0A068TRC7">
        <property type="interactions" value="1670"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRC7"/>
    <dbReference type="Gramene" id="CDO98504">
        <property type="protein sequence ID" value="CDO98504"/>
        <property type="gene ID" value="GSCOC_T00022623001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRC7"/>
    <dbReference type="OMA" id="KVSVRCF"/>
    <dbReference type="OrthoDB" id="271433at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRC7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070483">
        <property type="term" value="P:detection of hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF29">
        <property type="entry name" value="PLANT CYSTEINE OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="261" mass="28489" checksum="D68CCF63416397D6" modified="2014-10-01" version="1">MTKKTSSSSSSSSSSIQALYDLCKRTFTSSGNLPPSSKATQNLCSLLDTIGPADVGLRDENQEDDRGHGLLGLNLFNRVDRWAQPITYVDIHEGDSFTMCVFCFPTSSVIPLHDHPGMTVFSKVLYGSLHVKAYDWVEPALVQKGKQAGHPTVRLAKLAVDKVLTAPCSTSVLYPKSGGNLHCFTAVTPCAVLDILAPPYLEAAGRKCTYYHDYPYSTFSADGDEVQNGKEEDYAWLAEINTPDDLYMRSGTYTGPAIQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRS0</accession>
    <name>A0A068TRS0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00025571001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRS0"/>
    <dbReference type="FunCoup" id="A0A068TRS0">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRS0"/>
    <dbReference type="Gramene" id="CDO98682">
        <property type="protein sequence ID" value="CDO98682"/>
        <property type="gene ID" value="GSCOC_T00025571001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRS0"/>
    <dbReference type="OMA" id="TACHINS"/>
    <dbReference type="OrthoDB" id="1858060at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRS0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33181">
        <property type="entry name" value="OS01G0778500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33181:SF10">
        <property type="entry name" value="SSRA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="72" mass="8310" checksum="38C89965C271BBBB" modified="2014-10-01" version="1">MTSWVRTISSPFRKARTFFNQQSPRDDKSKQPAGHEKRVMDLQVEVMACAYEDVQVMWSILDKSKSGSNLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS43</accession>
    <name>A0A068TS43_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIFI-like Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022163001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS43"/>
    <dbReference type="FunCoup" id="A0A068TS43">
        <property type="interactions" value="1115"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TS43"/>
    <dbReference type="Gramene" id="CDO98158">
        <property type="protein sequence ID" value="CDO98158"/>
        <property type="gene ID" value="GSCOC_T00022163001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS43"/>
    <dbReference type="OMA" id="RCTMIGN"/>
    <dbReference type="OrthoDB" id="1900123at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010478">
        <property type="term" value="P:chlororespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057612">
        <property type="entry name" value="Ig_PIFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044960">
        <property type="entry name" value="RCA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32429">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32429:SF9">
        <property type="entry name" value="PROTEIN POST-ILLUMINATION CHLOROPHYLL FLUORESCENCE INCREASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25419">
        <property type="entry name" value="Ig_PIFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIFI-like Ig-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="291" mass="31277" checksum="20AF1AA554AA8D58" modified="2014-10-01" version="1">MAVTAAGSAATSSASLFASSQQIVSATRSASSSNTSVSVASTYVSNCMGASLRRCFPVKRKMAKISRIVTAAASVAASPVEEVTDYKLPTWAEFDLGRAPIYWKTMNGLPPTAGEKLKVFYNPAANKLVPNEEFGIAFNGGFNQPIMCGGEPRAMLQKVRGKVDPPIYTIQICIPKHALSLIFSFTNGTEWDGPYRLQIQVPRPWRNRPIEFFTEGLAQELSRDGACEKAIFPDTNVVATRCAMIGNLSVEGGDRCNLDFVVGCTDPSSPLFNPLANVDDGSCPLDSDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSM0</accession>
    <name>A0A068TSM0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00022414001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the auxin efflux carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSM0"/>
    <dbReference type="FunCoup" id="A0A068TSM0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSM0"/>
    <dbReference type="Gramene" id="CDO98348">
        <property type="protein sequence ID" value="CDO98348"/>
        <property type="gene ID" value="GSCOC_T00022414001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSM0"/>
    <dbReference type="OMA" id="FGSHEYG"/>
    <dbReference type="OrthoDB" id="1868374at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSM0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014024">
        <property type="entry name" value="Auxin_eff_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00946">
        <property type="entry name" value="2a69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF18">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO98348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="602" mass="66017" checksum="4567627D94F37B09" modified="2014-10-01" version="1">MITLVDFYHVMTAVVPLYVAMILAYGSVKWWKIFTPDQCSGINRFVALFAVPLLSFHFISANNPYTMNLRFIAADTLQKIIVLAVLAVWTKVSKRGCLEWTITLFSLSTLPNTLVMGIPLLKGMYGEFSGSLMVQIVVLQCIIWYTLMLFMFEYRGAKMLISEQFPDTAGSIVSIHVDSDVMSLDGRQPLETEAEIKEDGKLHITVRKSNASRSDIFSRRSQGLSSTTPRPSNLTNAEIYSLQSSRNPTPRGSSFNHTDFYSMVAGGRNSNFGANDVYGLSASRGPTPRPSNYEEENGNNMNKSRFHYPAAPGNTAHYPAPNPGMFSPTGSKVMGANAAAKKPNGQHKEEGAKDLHMFVWSSSASPVSDVFGGHDYGALDQPSKEVRVAVSPGKVEGHRDNQEDYMEREDFGFGNKGMDNNNDDDKMGDKQVKAMPPTSVMTRLILIMVWRKLIRNPNTYSSLIGIIWALVSYRWNVEMPAIIAKSIAILSDAGLGMAMFSLGLFMALQPRIIACGNSVAAFAMAVRFLTGPAVMAAASIAVGLRGVLLHVAIVQAALPQGIVPFVFAKEYNVHPDILSTAVIFGMLIALPITLVYYILMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSZ4</accession>
    <name>A0A068TSZ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00026589001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSZ4"/>
    <dbReference type="STRING" id="49390.A0A068TSZ4"/>
    <dbReference type="Gramene" id="CDO99420">
        <property type="protein sequence ID" value="CDO99420"/>
        <property type="gene ID" value="GSCOC_T00026589001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSZ4"/>
    <dbReference type="OMA" id="QQGKQAY"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSZ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.20:FF:000003">
        <property type="entry name" value="DNA/RNA-binding protein Alba 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF17">
        <property type="entry name" value="PROTEIN ARGONAUTE 18-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO99420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="242" mass="26665" checksum="74BA0EAEC9683E8F" modified="2014-10-01" version="1">MDRYQRVEKPRPEEPINENEIRITAQGLIRNYISYATTLLQEKREQEIVLKAMGQAISKSVAIAEIIKKRIPGLHQDTSIGSTTITDAYEPIEEGLEPLEMTRQVSLISITLSTNELNKNSPGYQAPSNIDQPRGENQQQQQPRQYVNIAENNLDSYGGRGRGRGRGRGRGRGRGRGGYGNYQGENGGYYNYGRGGGRGRGWGYRGSGYGRGRGGFQVGGRGYGRGRGRVGRGRGGVNQAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT41</accession>
    <name>A0A068TT41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Auxin response factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00029061001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TT41"/>
    <dbReference type="FunCoup" id="A0A068TT41">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TT41"/>
    <dbReference type="Gramene" id="CDO99470">
        <property type="protein sequence ID" value="CDO99470"/>
        <property type="gene ID" value="GSCOC_T00029061001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TT41"/>
    <dbReference type="OMA" id="NHHGRDI"/>
    <dbReference type="OrthoDB" id="624437at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TT41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140677">
        <property type="term" value="F:molecular function activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010158">
        <property type="term" value="P:abaxial cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010582">
        <property type="term" value="P:floral meristem determinacy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009835">
        <property type="term" value="P:fruit ripening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010050">
        <property type="term" value="P:vegetative phase change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF5">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0292">Fruit ripening</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="11">
        <location>
            <begin position="136"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO99470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="682" mass="75440" checksum="699A813EA4A5505D" modified="2014-10-01" version="1">MCGLIDLNTVNNDDDGNGSEMTPSASESVCMELWHACAGPLISLPKKGSRVVYLPQGHLEQLADQLSLSNIDLPPHIFCRVVDVKLHAEATTDEVYAQVSLLPDYQMEHKWKEGEVEVETEEDVEGAGKSLTPHMFCKTLTASDTSTHGGFSVPRRAAEDCFPPLDYEQQRPSQELVAKDLHGMEWKFRHIYRGQPRRHLLTTGWSAFVNKKKLVSGDAVLFLRGGDGELRLGIRRAAQLKSCSTFPTASQQFNASSIISVVNAVTTRRVFNVCYNPRAGSSEFIVPYQRFSKSVAHSISAGMRFKMRFETEDAAERRCTGLIVGISDADPVRWSGSRWRCLLVRWDDMEVSRHNRVSPWEIEPSGIVSGHSSLVTLGTKRTRTGLLTTKPEHSVARDATGISEYGDIRLQKVLQGQEIVGLNNPYDGFDASSQHPSEMKSFPNTKDSRISVVPNQLKSLQGDSFASHEVSFVEPFQFNQVLQGQETILNQSYGRGPAVDIVLESSGSSILNGVQVPGQGNRWSAIRGYPTHVQPPNPSGQLSSPSSVMMFHQASYPVSKVRDAQCGGNLEKLEACNRGLFDTSERYIRRISVCSPESQTAVSMCKNSCRLFGFPLAEGKNGTNEENQIQVKMPYDHDAAFVPENDVQLHPKPSLVTKVTGNSCTKVSDLYNVRDMLLDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUG8</accession>
    <name>A0A068TUG8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00025990001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUG8"/>
    <dbReference type="FunCoup" id="A0A068TUG8">
        <property type="interactions" value="1578"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUG8"/>
    <dbReference type="Gramene" id="CDO98993">
        <property type="protein sequence ID" value="CDO98993"/>
        <property type="gene ID" value="GSCOC_T00025990001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUG8"/>
    <dbReference type="OMA" id="LYGTWWG"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUG8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF24">
        <property type="entry name" value="OS07G0655900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="67"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="276" mass="30202" checksum="1614E2467CE0DC31" modified="2014-10-01" version="1">MAFKFSWVSFFKITLFLILVAAIATACYTLPIEKMLKNFLVWVEQDLGPWGPFVLAVAYIPLTILAVPASILTLGGGYLFGLPVGFIADSLGASIGAGAAFLLGRTIGRSFVISKLKDYPQFQAVAIAIRRSGFKIVLLLRLVPLLPFNMLNYLLSVTPVPFGEYVLASWLGMMPITLALVYVGTTLKDLSDVTHGWSEFSKTRWAFIALGLVVSVILIFCVTRVAKRALEKALAENEDFDGIAPSPQLPIVADSPVHLNEPFIIKIDPSQDNHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV41</accession>
    <name>A0A068TV41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00029965001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV41"/>
    <dbReference type="FunCoup" id="A0A068TV41">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TV41"/>
    <dbReference type="Gramene" id="CDP00150">
        <property type="protein sequence ID" value="CDP00150"/>
        <property type="gene ID" value="GSCOC_T00029965001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV41"/>
    <dbReference type="OMA" id="SCFKEMT"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045218">
        <property type="entry name" value="DA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022087">
        <property type="entry name" value="DA1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209:SF7">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12315">
        <property type="entry name" value="DA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP00150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="501" mass="56752" checksum="017F476FDD7CAD12" modified="2014-10-01" version="1">MSSSSVNHLSQPCIYGLSSYAERKSRFMKWLSKLFKGGSSSRGITSGHQPQFLGDENMVWRAPVRSLDDRSRANKEKEELDRAIALSLAEDLKRPQGYRWRSDHDEDLGSSLHGNLNSPYPPYAPREYYPRSYTICGGCNREIGTGNYLGCMGTFFHPDCFRCHACGSPITEFEFSLSGGYSYHKSCFKELAHPKCEVCDQFIPTNGAGLIEYRCHPFWSQKYCPSHEYDKTPRCCSCERLESRSARYISLGDGRSLCLECMESAIMDTGDCQPLYHAIRDYYEGMNMRIDQQIPMLLVERQALNEAIEGEKQGFHHMPETRGLCLSEEQTVTSILRRPRFGGHSLVGMTRQPQKLTRKCEVTAILVLYGLPRLLTGAILAHELMHAWLRLKGYRNLSPQVEEGICQVLSHLWLESEVMPEFRNMPSTSAASSSSSSTWSSSKKGAKSRIESKLGEFFMHQIANDASPAYGEGFRAANAAVKKYGLRRTLDHIRENRSFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV98</accession>
    <name>A0A068TV98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein KIN-10A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00026345001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-10 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV98"/>
    <dbReference type="FunCoup" id="A0A068TV98">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TV98"/>
    <dbReference type="Gramene" id="CDO99258">
        <property type="protein sequence ID" value="CDO99258"/>
        <property type="gene ID" value="GSCOC_T00026345001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV98"/>
    <dbReference type="OMA" id="MDMSIDF"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009524">
        <property type="term" value="C:phragmoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031535">
        <property type="term" value="P:plus-end directed microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000068">
        <property type="entry name" value="p-loop containing nucleoside triphosphate hydrolase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1019">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="60"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="413"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO99258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="952" mass="105729" checksum="F1A66E581038DD0E" modified="2014-10-01" version="1">MAPTPSSKPHSMMQTPSSKSNPAHNQTRTPQSKQRLNFNVSKPSPNHNSSAMAKESNNPPAEHPVEINPDKQSLRVKTEIGYRDFSLDGVSLSEEEDLDAFYKKFVESRINGVKLGDKCTIMMYGPTGAGKSHTMFGCGKQPGIVYKSLKDILGEGEEVGEENGEKLGPATFVQVTVLEIYNEEIYDLLSTNNGGGFNLGWAKGGSASKVRLEVMGKKAKNASFIAGHEATKISREIQKVEKRRIVKSTLCNERSSRSHCMIILDVPTVGGRLMLVDMAGSENIEQAGQNGLEAKLQTAKINQGNTALKRVVESIANGDSHVPFRDSKLTMLLQDSFEDDKSKILMILCASPDPKELHKTISTLEYGAKAKCIVRGPHTPIKERGAEDSSSAVILGSRIAAMDQFIYKLQMENKLREKERNDAQKELTKKEEEIAALRAKVSLAEGKGHDTMEEEINLKANQQVQKLKSELEKRIQECEKMADELIEMERRKMENVVLQFQQESEMLRQRLRELESELYKSRVGGGSLDMDGSNFVRKLLDTYSEDSGMVKSMDLDKSYDLDAGKQDVVVFKAGNSETKSYLDFDSRKNSRDDKDYDLLVRSFSSKGCLSTVFEADEEEGSGDDKEKFSDEEVRKEVIEEKVVCSSTLAAKAPSIPVSSPEVSSQNQEKVENFRETLVDKLLQAESPSEPESAQDTASSRLMRIQNIFTLCGNHRELSQHIRTPMPGRKRSENIDPMASPVRTTEEGSDAKSISDVKQLQKSLSKDLLVSDIPENFQTPMGNKKMAPSSFESTLASKENCNPIDEKIGDLDVYVKWEASMENPGKFITTLKVVKDSTLADLRKLIEIHLGGDNQAFTFLVLGDPSGAPVPRETEATMQASKLPICNNQLPGRLACLRPLKGTRNTPHHLPLSPLENKLPLTPISNVTKHCDYPSPELPTHLDSTPFVTLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVI8</accession>
    <name>A0A068TVI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta(3)-Delta(2)-enoyl-CoA isomerase</fullName>
            <ecNumber evidence="5">5.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029839001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVI8"/>
    <dbReference type="FunCoup" id="A0A068TVI8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVI8"/>
    <dbReference type="Gramene" id="CDP00062">
        <property type="protein sequence ID" value="CDP00062"/>
        <property type="gene ID" value="GSCOC_T00029839001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVI8"/>
    <dbReference type="OMA" id="VAMIRMK"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF84">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="246" mass="26995" checksum="061D07456C134DF6" modified="2014-10-01" version="1">MCTLEKRGNLFILTIIGDDEHRLNPTLIDSIREALHRARGECSGPSALITTAHGKFFSNGYDLAWAQSDRSRLLLMDAKLRCLISDLINFPMPTIAAVTGHASAAAFAFAMAHDYILMRKDRGFLYMSELDIGLVIPPWFVTLLKSKAKSPVAWREVVLKAAKLTAEMGMEMGIVSSAHVSAEETVKAAVELGEALVARKWDGEVYSENRRMVFVEVLAATRSHETGAGGDDEKRAESVAKTLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVR3</accession>
    <name>A0A068TVR3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00032242001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVR3"/>
    <dbReference type="STRING" id="49390.A0A068TVR3"/>
    <dbReference type="Gramene" id="CDP00336">
        <property type="protein sequence ID" value="CDP00336"/>
        <property type="gene ID" value="GSCOC_T00032242001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVR3"/>
    <dbReference type="OMA" id="ICTHWYQ"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVR3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF698">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="410" mass="44878" checksum="6BBD2C4815022994" modified="2014-10-01" version="1">MDSLNVDTVESQNQLPQPQKGTTFLRTCFNGLNAVSGVGILSIPYALSEGGWLSLTILFLVAVLCYYTGLLLQRCMDVDPLVRTYPDIGELAFGKKGRLTISTFMYLELYLVAVEFLILEGDNLHKLFPDACFHLGGKKVGGKQVFVLLTALIILPTTWLRNLGLLAYVSVGGVLASFVLLGSVFWVGAIDDVGFHETGSLWRWSGLPTAISLFTFCYCGHAIFPTLCNSMKDRSQFPKVLLVCFVLSGLTYGSMAVLGYLMFGDNLSSQVTLNLPTAKISSKIAIYTTLINPITKYAIIIAPIATAAEDAFRFRNSRTMSLLIRTSLVVSTVVVALCIPFFGYVMGFIGAFLSISVSMLFPCLCYLKIKKADKRWGPELVSIMLILVLGIIVSALGTYISVRNIVRNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWH6</accession>
    <name>A0A068TWH6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00032191001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWH6"/>
    <dbReference type="FunCoup" id="A0A068TWH6">
        <property type="interactions" value="2643"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWH6"/>
    <dbReference type="Gramene" id="CDP00299">
        <property type="protein sequence ID" value="CDP00299"/>
        <property type="gene ID" value="GSCOC_T00032191001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWH6"/>
    <dbReference type="OMA" id="WINEQNF"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWH6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000258">
        <property type="entry name" value="Probable serine/threonine-protein kinase PBL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="86"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="419" mass="45983" checksum="6BAD6F53DDAA5972" modified="2014-10-01" version="1">MGNCLGSSARVDATLSSHTLPASETLRIPSKTSNSSAPSTLTLPSYSGKSGSFDSIPTPRSEFEILSSPHVKSFPFSELRNATRNFRPDSLLGEGGFGYVFKGWIDEQTLTPSKPGSGMVIAVKKLKPEGFQGHKEWLTEVNYLGQLHHPNLVKLIGYCSEGDNRLLVYEFMPKGSLENHLFRRGAQPLPWATRMRVAIGAARGLAFLHDAEEQVIYRDFKASNILLDSEFNAKLSDFGLAKAGPTGDRTHVSTQVMGTHGYAAPEYIATGRLSAKSDVYSFGVVLLELLSGRRAVDKGKVGVEQNLVDWAKPYLGDKRKLFRIMDTKLEGQYPQKGAFTAANLAMQCLNPDPKVRPRMTDVLTALEDLPSPKSLKHSPSEYQASPDPARHSLKQNRSPLNMTPCASPLPTQLKSPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWM9</accession>
    <name>A0A068TWM9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032665001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWM9"/>
    <dbReference type="FunCoup" id="A0A068TWM9">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWM9"/>
    <dbReference type="Gramene" id="CDP00651">
        <property type="protein sequence ID" value="CDP00651"/>
        <property type="gene ID" value="GSCOC_T00032665001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWM9"/>
    <dbReference type="OMA" id="FDIVAYV"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWM9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000534">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000032">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="230"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="533" mass="59598" checksum="976FAF2A4124185E" modified="2014-10-01" version="1">MAAANHKLAVIIKNPLDKEEFLLIKQTPPPKFNDPEYDSFVDTDLWDLPSTQLTPLSEPDQLLHSKISIKTREFSSSDKINLSEFDFNSALNQALEQVGYGSAREVEWEFWKCLEEPDFGPGLPIKTVYIVGNLGSQDGKLKEVCKWIRMENCLEMLLEVKPNSDRVGPLAVLGLLNDMAPSESWKVPPTSHCQEYPPGLKLVPMGSRTGKPFRTTNLVIFVPGNKTDSSSNNSFIACGDALIVDPGCSSAFHRELEEIIAALPKKLVVFVTHHHHDHVDGLSVVQKCNTGATLLAHENTIRRIGKDDWSLSHVAVSGSEEVYIGGQLLRIIHAPGHTDGHMALLHVSTNSLIVGDHCVGQGSAVLDVTSGGNMTEYFRTTYLFMDLSPHNLIPMHGRINLWPKHMLCGYLKNRRNRESTILKSIEDGAKTLFDIVSYTYAEVDRSFWIPAASNVKLHVDHLAEQDKLPKEFSIQRFQNSCRLHFLSHWMWAYLRGGSFPIRHYIARTAEIVGAAAIVGLAAMYFSRNKLDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWQ7</accession>
    <name>A0A068TWQ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00032452001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWQ7"/>
    <dbReference type="FunCoup" id="A0A068TWQ7">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00497">
        <property type="protein sequence ID" value="CDP00497"/>
        <property type="gene ID" value="GSCOC_T00032452001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWQ7"/>
    <dbReference type="OMA" id="FGSYVFV"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000284">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000442">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g49710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000196">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g14850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000472">
        <property type="entry name" value="Putative pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF511">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="621"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="713" mass="79631" checksum="AF237FA487C52141" modified="2014-10-01" version="1">MSGISSYCCSILKNCCENKNLIQAKKLHCIIIKTLENPETFLLNNLIHSYIKLHNVVYARNVFDKIPKPNLFSWNTILSAYSKSGNLSKMEEVFKLMPKKDGVSWNLIISGYASRGMSNEALKAYKLMIRDGLGSLNRITFSKMLILSLNKGWIELGRQVHGQITKCGFMSYVFVGSPLVDMYAKSGLICHAKQVFDDHMTEKDSISWTTMITGLTQNCLEIDAIDFFRNMMLEGLAVDQFTLGSILTACGGLIALKEGKQVHAFAVKTNHVDNVFVGSALVDMYSKCRSITSAETIFKSMPYKNIVSWTAMVVGFGQNGYSEEAIQIFCEMQRIGIEPDEYTLGSVISSCGNLASLEEGGQFHAQAQVSGLISFTTVANALVTLYGKCGSIGDSHQMFNEMKIKDEVSWTALLSGYAQFGKANETVDIFEKMLASGLQPDSVTFIGILSACSRAGLVKEGHHYFQLMVEEYGIKPMVDHYTCMIDLLSRAGKLKEAKDFIQKMPCKPDAIGWATLLSSCRSRGNIEIGKWAAKYLQELDPENPASYVLLSSMYASRGLWGEVAQLRRRMRDKGVKKEPGCSWIKYKNKVHIFSADDKSSPFSDQIDNELEKLNLKMIDEGYIPDVSSVLHDIEESEKIKSLNHHSERLAIAFGLLFVPPALPIRVVKNLRVCGDCHNATKIISKITQREILVRDAVRYHLFKDGKCSCGDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWX5</accession>
    <name>A0A068TWX5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00032396001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWX5"/>
    <dbReference type="FunCoup" id="A0A068TWX5">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWX5"/>
    <dbReference type="Gramene" id="CDP00454">
        <property type="protein sequence ID" value="CDP00454"/>
        <property type="gene ID" value="GSCOC_T00032396001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWX5"/>
    <dbReference type="OMA" id="QATQRHR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWX5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000557">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="171" mass="19485" checksum="DE32F067D8FDD7F2" modified="2014-10-01" version="1">MNQAVQKNTLYVGGLAEEVNESILHSAFIPFGDIKDVKTPLDQATQKHRSFGFVTFLEREDAAAAMDNMDGAELYGRVLTVNYALPERIKGGEQGWAAQPIWADADTWFERQQQEEEMQRLQAEHRAAMQAAEELHRQKMADEREGEKEEETDIVNDPMRKAEEEALMQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ53</accession>
    <name>A0A068TZ53_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IST1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032630001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ53"/>
    <dbReference type="FunCoup" id="A0A068TZ53">
        <property type="interactions" value="2805"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZ53"/>
    <dbReference type="Gramene" id="CDP00628">
        <property type="protein sequence ID" value="CDP00628"/>
        <property type="gene ID" value="GSCOC_T00032630001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ53"/>
    <dbReference type="OMA" id="DLQLKHM"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000003">
        <property type="entry name" value="IST1-like protein isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF81">
        <property type="entry name" value="OS01G0687700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35235" checksum="EF1A81B29507D9B7" modified="2014-10-01" version="1">MSLLNQLFNRGLLGQKCKTCLTLTISRIKLLQNKRDGQLKIMRKEIAQFLQAGQESIARIRVEHVIRERNIWDAYEILEMFCEFVLARVPILESQRECPSELREAVASIIFAAPRCSDLPDLVHVRNLFAAKYGKEFIAAASELRPDTSVNRTIIEKLSVSAPSAEVKMNILKEIAREYNVNWNSSKTEAEFSKKPEDLLNGPKHIAAPSLSVSQSSAVHSPPILEHSNTSLNGQQGHSNQSAVAVNNIPRLATNKPKPPSLKDQSVEPKTESKETRSQSSDPLEKARAAIAAAERASAAARAAAELVNFNFSSEARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ69</accession>
    <name>A0A068TZ69_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00032653001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ69"/>
    <dbReference type="STRING" id="49390.A0A068TZ69"/>
    <dbReference type="Gramene" id="CDP00643">
        <property type="protein sequence ID" value="CDP00643"/>
        <property type="gene ID" value="GSCOC_T00032653001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ69"/>
    <dbReference type="OrthoDB" id="779054at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP00643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="9353" checksum="782D04BF95DADCDC" modified="2014-10-01" version="1">MVFSSNPLALSVPDLAFESWLRDKGYLEILDQRTSDLHLHFHRHRTIHPLFLLLQHHRHHHPLWPRYLPLFPLKIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0U4</accession>
    <name>A0A068U0U4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00036943001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0U4"/>
    <dbReference type="FunCoup" id="A0A068U0U4">
        <property type="interactions" value="1812"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0U4"/>
    <dbReference type="Gramene" id="CDP01784">
        <property type="protein sequence ID" value="CDP01784"/>
        <property type="gene ID" value="GSCOC_T00036943001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0U4"/>
    <dbReference type="OMA" id="CKWPREA"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0U4"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="21007" checksum="3BDF1BB5FA4F6BFA" modified="2014-10-01" version="1">MGESSAAADAYENGRYKYIHDIHKGPPEAIDVHHIVLQRSSQKKLLIFCFLTLLLFASSPFFFFLQQLNLLTTLPWSLLLGGLFVRLLSQKLVKKESVIILPAFGVQLETQYGSGRTIRRFVPINKILKPVLNECVTPVTCYWSLALIIRGEEELMLVFKELYPPVKMLVPIWKAVCAAIDVEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U176</accession>
    <name>A0A068U176_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00039632001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U176"/>
    <dbReference type="STRING" id="49390.A0A068U176"/>
    <dbReference type="Gramene" id="CDP02280">
        <property type="protein sequence ID" value="CDP02280"/>
        <property type="gene ID" value="GSCOC_T00039632001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U176"/>
    <dbReference type="OMA" id="EMEFIRD"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U176"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651:SF50">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="524"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP02280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="717" mass="81819" checksum="F516D9D49BA927F5" modified="2014-10-01" version="1">MPDANRFSPLCLWIAKQFQRLNPCSSDLEADDSIYPYACYACTQVGVPVFHSTTCDPDHQPEWEASAGSSLLPINCRKSRTGDNPSPPGLLPGRVLDPRSARVQRWNRIILLARAVALAVDPLFFFAMSIRVRGGGGAADNQPCIYRDRGVATIVSAIRTCVDLVHTCHFWLQFRLAYVSKESLVVGCGKLVWDPRAIASRYLMSPAGFWLDVFVMLPIPQAVYLLVVPKLLEADRIRLTLSILPIIFLMQFLPKVYHSFSLMRRMRKVTGYIFGTIWWGFGLNLIAYFLASHVSGGYWYILAIQRIASCLAQQCDRSKASCNKKLSCAMEVCYWASRSTCAVGNSTTAHKPLCLDDAGPFHYGLYKFALPLFSKNSAMTKILYSNLWGLMALRLKLIFGLLLYSTMGNNLEPTCRCLEVIFTIFMVLGGLMLFTLLIANIQVFLHAIMVRRKEMQLRYRGIEWWMRHRQLPSNLKCRVRRYENQRWKLAGGQDEMEFIRDLPEGLRRDIKHYLCLGLIKKVPLLCSLDDLILDNICDRVKPLVYSKDEKIIREGDPVQRMIFIADGRIRRSQSLGEGAVANSMLEAGSFLGDELLSWCLRRPVADRLPASSATFTCIEPAEAYALDADDFRYITNHFRFHFANKNLKQTARYYSSNWRTWAAVNIQIAWRHYKTRARGSTNQLMLENGGNDSRRRLRQCAAFFMSLRPHDHPGLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U183</accession>
    <name>A0A068U183_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00039595001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U183"/>
    <dbReference type="STRING" id="49390.A0A068U183"/>
    <dbReference type="Gramene" id="CDP02251">
        <property type="protein sequence ID" value="CDP02251"/>
        <property type="gene ID" value="GSCOC_T00039595001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U183"/>
    <dbReference type="OMA" id="NSHAMWQ"/>
    <dbReference type="OrthoDB" id="753675at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U183"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF12">
        <property type="entry name" value="CASP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="9">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP02251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="189" mass="19669" checksum="3312AC73978E107E" modified="2014-10-01" version="1">MPFKKKTKVSPEPEVDEESNESAPKAGANRGISKLDLAMRMVAAIGTLGSALAVGTANGAGPFFAGFFRFGAGYDDLPTFTFLVVTNAIVCGYLVLSLLLSIFHILKSSARVTRVILIILDTVMVAYLTGGASSAAAMVHLAHKGNGGAICQQHNSFCDRVAGALVGSFIGVVVLLLLISMSAVALSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1D2</accession>
    <name>A0A068U1D2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00036460001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-arogenate from prephenate (L-Asp route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-arogenate from prephenate (L-Glu route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1D2"/>
    <dbReference type="FunCoup" id="A0A068U1D2">
        <property type="interactions" value="782"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1D2"/>
    <dbReference type="Gramene" id="CDP01418">
        <property type="protein sequence ID" value="CDP01418"/>
        <property type="gene ID" value="GSCOC_T00036460001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1D2"/>
    <dbReference type="OMA" id="IEPFHVM"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1D2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033853">
        <property type="term" value="F:aspartate-prephenate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033854">
        <property type="term" value="F:glutamate-prephenate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009095">
        <property type="term" value="P:aromatic amino acid family biosynthetic process, prephenate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000033">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="113"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP01418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="488" mass="52888" checksum="1B4D251532544DC8" modified="2014-10-01" version="1">MPAASSYSLQTCSSSARSIASKTTQPLALTDRHQRCRSLSFSSQLHRLDLSIKIADSRRELDSNRLNAVVRAQSSLGTMEVDISLSPRVNSVKPSKTVAITDQATALVQAGVPVIRLAAGEPDFDTPAVIAEAGINAIREGYTRYTPNAGTSELRSAICRKLKEENGLSYTPDQILVSNGAKQSILQAVIAVCSPGDEVLIPAPFWVSYPEMARLADATPVILPTQISDNFLLDPKLLESKLTEKSRLLILCSPSNPTGSVYPRKLLEEIAGIVARHPRLLVLSDEIYEHIIYSPATHTSFAALHGMWERTLTVNGFSKAFAMTGWRLGYLAGPKHFVSACNKIQSQFTSGASSISQKAAVAALEMGYAGGEAVATMVKAFRERRDFLVKGFRELDGVKISEPQGAFYLFLDFSSYYGAEIDGFGKIDGSESLCRYLLDKAQVALVPGEAFGDDTCIRISYAASLSTLQAAFERIKKALVTLRPPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U341</accession>
    <name>A0A068U341_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetylajmalan esterase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00041354001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U341"/>
    <dbReference type="STRING" id="49390.A0A068U341"/>
    <dbReference type="Gramene" id="CDP02931">
        <property type="protein sequence ID" value="CDP02931"/>
        <property type="gene ID" value="GSCOC_T00041354001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U341"/>
    <dbReference type="OMA" id="PYLNVNT"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U341"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF677">
        <property type="entry name" value="ACETYLAJMALAN ESTERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657560" description="Acetylajmalan esterase-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40658" checksum="045D8C27195D9CE6" modified="2014-10-01" version="1">MAPGFTFFYSSLLIGSYISVAATASRRNFVCPFDSLYQFGDSISDTGNVIRVPGVGPTLPAARFPYGQTIGRPTGRWSDGLLIIDFTAMDLHLPLLNPYLDRNASFNNGVNFAVAGSTALDFAFFTARGIAVPIVTSPLGVQVNSFKQYLSSICCSPTECSTKLRQSLFWVGEIGGNDINYAFTQGKSLQEIRTYIPSITQAIINNTRQIIQLGAKRIVVPGNFPLGCIPVALNFVSNASSQEFDEFGCSRSFNDLARYQNSYLQNALNSLRKEFPDAVIVYADFYGSFRSVLTRASFLGFDAGSLLKACCGIGGPYNYDMNRACGSPGVPVCPNPRRFIHWDGLHLTQQAYRRISEFLIPDILSRIQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4W6</accession>
    <name>A0A068U4W6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041675001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4W6"/>
    <dbReference type="STRING" id="49390.A0A068U4W6"/>
    <dbReference type="Gramene" id="CDP03174">
        <property type="protein sequence ID" value="CDP03174"/>
        <property type="gene ID" value="GSCOC_T00041675001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4W6"/>
    <dbReference type="OMA" id="MNYAIII"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4W6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF2">
        <property type="entry name" value="PRA1 FAMILY PROTEIN F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="20624" checksum="C7EE0CC24F442D44" modified="2014-10-01" version="1">MTTMYGTIPTSDFYADRLDRVRSDLGKRRPWKEMLSSLSFPDGFQHSLSRINTNVAYFHMNYAMIVLFVLFLSLLWHPVSLIVFTVLMVAWLFLYFLRDDPIVVFGYAVDERVVLTILSISTVVLLVTRTTLNVVVGVAVGLAAVVVHGAFRMTEDLNVYGNEGVGGPTRLDLMETAAASFSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7B1</accession>
    <name>A0A068U7B1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00017766001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DH200</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DH200</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7B1"/>
    <dbReference type="Gramene" id="CDP04391">
        <property type="protein sequence ID" value="CDP04391"/>
        <property type="gene ID" value="GSCOC_T00017766001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7B1"/>
    <dbReference type="PhylomeDB" id="A0A068U7B1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP04391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="538" mass="58386" checksum="FB7B2E9DA7A7EBF6" modified="2014-10-01" version="1">MEFNNQENQVHDAKQQQPSEQPASEHITTIDSKTEAILSDISLPRFRRLWWATGAELKTLFQIAAPACIVYLLNSVMSTSTQVFCGHLGNLEFAASSLGNNGLSVLAFGLMLGMGSAVETLCGQAYGAKKYDMLGIYLQRAAILLVATAIPLMIAYIFSKPIFLLLGQKKEVASAAAVFVYGLIPQIFLYAFNFPIQKFLQAQSIILPSAVIAAVALAVHMLLTWFALFKFGWGLLGAAFVLSFSWVLIVVPQFVYILVSDRCRKTWNGFSMQAFSGLWSFYKLSAASAVMLCLECWYFQIMVLIAGLLPNPEVALETVSICLTINGCMFMISSGFNAAARQEFFSSPLLWNLIKNSSSYSYSVRVSNELGAGHAKAAAFSVLVVTASSSLIALTVAILVLAYRHVISYAFTSGKQIAIATSELMPILAISITLNGIQPILSGVAVGCGWQKFVAYVNVGCYYGVGVPLGTLLAFKFKLGAKGIWSGLSGGMAMQTLILIWVTCRTNWDAEVEKARKRLEKWNDQTEGSSSSGGNVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA12</accession>
    <name>A0A068UA12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00019944001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA12"/>
    <dbReference type="FunCoup" id="A0A068UA12">
        <property type="interactions" value="2625"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UA12"/>
    <dbReference type="Gramene" id="CDP05034">
        <property type="protein sequence ID" value="CDP05034"/>
        <property type="gene ID" value="GSCOC_T00019944001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA12"/>
    <dbReference type="OMA" id="RPMGPVF"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="8">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="40474" checksum="7688293D4BD413AE" modified="2014-10-01" version="1">MAEWQQFIQSVFFGVIFSFLLAKLFAVIFAFREENLRVVRGDPTEESQSKPSAAAIEREISESDSRVFEEKKPLIADTEKDIAAAVAKESGSVITPGGDDTYTSGSDSDSDWEGVESTELDEAFSAATAFVAATAADRSSQKVSNDVQLQLYGLYKIATEGPCSTPQPSPLKMTARAKWQAWQKLGAMPPEEAMQKYIEIVTELYPSWITNTATKKQGKESSGASSAGSRGPMGPVFSTFTYEDEPGNDLKLDAIHAFAREGDAGNLLQCIENGFPVNAKDSEGRAPLHWAVDRGHLNVTELLLSKGADINAKDNDGQTALHYAAVCERATLAEFLVKHKADIEIKDNDGNSPADLCELNWPWMQQSASVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAW4</accession>
    <name>A0A068UAW4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020786001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAW4"/>
    <dbReference type="FunCoup" id="A0A068UAW4">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAW4"/>
    <dbReference type="Gramene" id="CDP05626">
        <property type="protein sequence ID" value="CDP05626"/>
        <property type="gene ID" value="GSCOC_T00020786001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAW4"/>
    <dbReference type="OMA" id="VHPRTCC"/>
    <dbReference type="OrthoDB" id="785270at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47005">
        <property type="entry name" value="HEAVY METAL TRANSPORT/DETOXIFICATION SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47005:SF5">
        <property type="entry name" value="HEAVY METAL TRANSPORT_DETOXIFICATION SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24721" checksum="99154B07690D4D86" modified="2014-10-01" version="1">MRLNVDLQCPSCYKKVKKILCKFPEIRDQVYDEKHNLVTITVVCCSPEKIRDKLCCKGDKVIKSIEIVELPPPPKPKPPEKPKEPEKPKEPEKPKEPAKLKETDKPKEPAKPPVVVVVVEKPKIPEKPPFEPVPIIPPPPPPAPVPVEPCLHPPVPVGVCCVPCSEGYGGGPCYYWYGQPVPPLPYYDSYGYEYGYGYGKGYPYSRCDYFSEENAGGCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCB9</accession>
    <name>A0A068UCB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020259001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCB9"/>
    <dbReference type="STRING" id="49390.A0A068UCB9"/>
    <dbReference type="Gramene" id="CDP05273">
        <property type="protein sequence ID" value="CDP05273"/>
        <property type="gene ID" value="GSCOC_T00020259001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCB9"/>
    <dbReference type="OMA" id="MVHIHTI"/>
    <dbReference type="OrthoDB" id="1935281at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18914">
        <property type="entry name" value="bHLH_AtORG2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="320" mass="36042" checksum="66A84C1B6EB4D6AA" modified="2014-10-01" version="1">MIKGTYYLVMYCPHSSCNRMVHIHTISPLSTTWCEHVSGVLGPVFVRYPNWADLRGLDMYPLQQGNELENQNPCRPCQPDKILNDLVTLESTASLPPATSITGKKHHHRRFLPAIQQENKKQDHEDTTTTNSNQHKLKRILHRDIERQRRREMANLYASLRSLLPLDYVKGKRAISDHMQEAVNYIKCLQKNINQLGSRRDRLMIPLCNLSSTFSFSSGNRSTSADSQCLRDCGAIVRVSQGGDGVEVLISISSKEETFPISRVLKMLLGEGLDVVSCVSTATNEIKVHKILAEVTDGRKSIDTLALQHQLMNAINPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCF5</accession>
    <name>A0A068UCF5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021565001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCF5"/>
    <dbReference type="FunCoup" id="A0A068UCF5">
        <property type="interactions" value="1732"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCF5"/>
    <dbReference type="Gramene" id="CDP06166">
        <property type="protein sequence ID" value="CDP06166"/>
        <property type="gene ID" value="GSCOC_T00021565001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCF5"/>
    <dbReference type="OMA" id="LHIRERI"/>
    <dbReference type="OrthoDB" id="772275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCF5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37174">
        <property type="entry name" value="FORKHEAD-ASSOCIATED DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37174:SF2">
        <property type="entry name" value="FORKHEAD-ASSOCIATED DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="285" mass="32227" checksum="0FEF5FF88BFE3AB1" modified="2014-10-01" version="1">MILNWPSIFVQPKLPMVRTACFASGVNTDQLREQLDNLHKEAETTRAKANSARLRFLRLSEAAEKLRQQAALSVQTAKDNDARELLLQKRKVMQAMEKSKNRIELLDELAAKLTEVISVKETELIGNVALDLEVGGDAAPTPVRFVSPKEEVLKTSTDVNYFDQNEKLGQNEELEGAALNLPELHSSDELNNREQPVDGDVCKEDDAVHGVKEISSYEDFLECIDCHLHKVEVEILSLLKFSRLILEIKENEEKSKVQHVVEILKDVLHIRERIGSIKKTEVGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDK2</accession>
    <name>A0A068UDK2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00023478001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDK2"/>
    <dbReference type="STRING" id="49390.A0A068UDK2"/>
    <dbReference type="Gramene" id="CDP06576">
        <property type="protein sequence ID" value="CDP06576"/>
        <property type="gene ID" value="GSCOC_T00023478001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDK2"/>
    <dbReference type="OMA" id="GVDTRMM"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045000">
        <property type="entry name" value="TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898">
        <property type="entry name" value="TROPINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898:SF28">
        <property type="entry name" value="TROPINONE REDUCTASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="122" mass="13643" checksum="7E9B3E112FC7C2BB" modified="2014-10-01" version="1">MGINVESPFHRSQLAYPLLKADQRIWRVKNLACEWAKDNIRVNTVAPWAVRTTLMKQELDQSLAGKYPPLLSRTPLRQFAEADEISPLVAFLCLPAASYITGQVIYVDGGFTAGTYIRGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDY4</accession>
    <name>A0A068UDY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00021142001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDY4"/>
    <dbReference type="FunCoup" id="A0A068UDY4">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDY4"/>
    <dbReference type="Gramene" id="CDP05843">
        <property type="protein sequence ID" value="CDP05843"/>
        <property type="gene ID" value="GSCOC_T00021142001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDY4"/>
    <dbReference type="OMA" id="WQMTEVL"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000225">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF43">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="328"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="484"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP05843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="601" mass="68177" checksum="0E598DDAF8AACA5C" modified="2014-10-01" version="1">MVIKLIFRPNCLPFSVLSFPPRLFSRPLNFSLLSTSTTTAVAAVSSTLPYGPSLRKGHSPSPFPPTLHQCPSSEQESDSNLFDEDSFTRVFDLAALRVPSELCFGLENRLRGHLLNWPRVRNIARVPGDEIDAELKKLFPDCSSSNNLNTDNDALVTLNRRIYGKADGDGELLSPVLYRDKLARTFNSRGFVNFRNLAKISRPKKVKKKEEERKEKGKKGGVGRNEMAVVAVVEEEESDVSGLLGDEFKGKSWRGSTRLLLLDETYANKGINEMPEAIKAVLKEYVGDKGDSTFELVKCKLTLFYSYWQMNEVLEALLPNGMIIPSAFETVGHIAHLNLRDEHLPYKKIVAKVVLDKNKPKIQTVVNKTDIIHNDYRTMQLEVLAGNHSLVTTVVENGLRFHVDLATVYWNSRLSTERQRLLNYFTRDDVICDVFAGVGPIALAAARKVKHVYANDLNPYAVDYLERNSVLNKLEKKIEVFNMDGRRFIDTIFASHKTRPVTQVVMNLPNDATEFLDAFRGLFRKHHKDRGYTLPRIHVYGFSKAQDPEFDFHERIRIALSEVAFDVEMHRVRIVAPGKWMLCASFTLPERVAYSKTVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEM6</accession>
    <name>A0A068UEM6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein bL9c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">50S ribosomal protein L9, chloroplastic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">CL9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00024108001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEM6"/>
    <dbReference type="FunCoup" id="A0A068UEM6">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEM6"/>
    <dbReference type="Gramene" id="CDP07025">
        <property type="protein sequence ID" value="CDP07025"/>
        <property type="gene ID" value="GSCOC_T00024108001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEM6"/>
    <dbReference type="OMA" id="FAIRWTK"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.430.100:FF:000005">
        <property type="entry name" value="50S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.10:FF:000006">
        <property type="entry name" value="50S ribosomal protein L9, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="entry name" value="Ribosomal protein L9, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_bL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_bL9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_bL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_bL9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="Ribosomal protein L9 C-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="13">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP07025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="22201" checksum="78B6F41E78E5C6AE" modified="2014-10-01" version="1">MASAAASLSWGSSSWLSSHCLTQCMRPEATKLPEKTSILMVVAQKKAKKTRKIILKEDVADLGKKGQLMDVKAGFYRNYLFPLGKAQIVTPLLLKEMKMEEERIEAEKKRVIEEAQQLALIFETVGAFKVKRKGGKGKQIFGSVTAQDLVDIIKAQTQRDVDKRIVSVPEIRETGEYIAELKLHPEVTARVRLIVYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFG5</accession>
    <name>A0A068UFG5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024351001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739109">
        <property type="protein sequence ID" value="CDP07186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFG5"/>
    <dbReference type="FunCoup" id="A0A068UFG5">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFG5"/>
    <dbReference type="Gramene" id="CDP07186">
        <property type="protein sequence ID" value="CDP07186"/>
        <property type="gene ID" value="GSCOC_T00024351001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFG5"/>
    <dbReference type="OrthoDB" id="6253837at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFG5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="535" mass="61275" checksum="BEB2383BF9983EB2" modified="2014-10-01" version="1">MDEEEGGGIRLSKRFSDKGGEVDYKTKAGTAWSHSYLNQKPWHPLSYPNQRRKWIAEQTHAQRERRAEEVAREYAQEQEFFRQSALISKKEKEKMETMKAVSFMYVRPPGYNAESAKAADMADERKKQEQEQNNTSQGPFEHGASTSMKHESLPSSEEKKKPRPKDVFGRALPTEEQFEVLKNAPRLETGVAGRSKPFGVEIRNVKCLRCGNFGHQSGDRECPLKDAIMPSEENRLKRDDPLTAIQALTDVNEPLKWELKQKPGLSPVRGGFRADDPNQQIVAEDIFDEYGGFLSGDNIPDLLANFSSSEPKKKSSSKRKHKRQLSPTEVSGREKWSSSNDDGGRRLEKKRHKKSSRKHSHSSLADNLDSNMLQKGNRSLAGGDRDRHLKKKRSDRKSQKHSVSSLQENSDSDVPYDHRDNGSSSGDDRKRRSKLSPSSGDDHGRRLEKKRHHKSPRKHSRSNDGSSSGDDRKRRSKKIHKRKSPKDSYSSQSEISDYDRHCRSSRYKHSHPTSSENSDSDGHYRNRRHRHGYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFW7</accession>
    <name>A0A068UFW7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00024298001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP07157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFW7"/>
    <dbReference type="STRING" id="49390.A0A068UFW7"/>
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        <property type="gene ID" value="GSCOC_T00024298001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFW7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Heat stress transcription factor B-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF456">
        <property type="entry name" value="E2F_DP FAMILY WINGED-HELIX DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="11">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="343" mass="39731" checksum="81FE38538816AED7" modified="2014-10-01" version="1">MEVRGRGIAGNGGIVRPSSLPSKQVSEKMGFMKGVRGFTPPPFLMKTFQMVEDTETNNMISWNFEGTSLIILDHLKFAAEVLPKYFKHSNLSSFIYQLNNYGFRKIGLRQYEYENKWFQRGQEHLLMNIRRRNDEDPTIRKRREPREQHVTAARPSIEAKLEIFEDHMNALKEDITRSKYHMGKLESSIAIFKKNVKKMEAKSKALIKVLARIFSPALVEKIIQRVEEEPELEILQTMKRRRVILPQSSKTTTKSMDDGACGMDQDDQEANTSMAESKKSADQKLWKKFMGDDSVSEDESEQQLLKQHSRIDMEFDDLMVSKIMNAKEPNLDVEDEVAVDLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGI7</accession>
    <name>A0A068UGI7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00024892001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="ANCPAFV"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:pollen germination"/>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BnaA09g28200D protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BnaA09g40460D protein"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="JINGUBANG-like"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844">
        <property type="entry name" value="F-BOX AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF336">
        <property type="entry name" value="PROTEIN JINGUBANG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="6"/>
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="444" mass="48860" checksum="97E12471566CE524" modified="2014-10-01" version="1">MFSDTSSLPPKIGNMTHSDPNICSAATDDEMAARHSSFSGYDVSRLSGEMSPMTMSPWNQNSPFTQSPWSKFDENVPQNVPQNGLIGSLVREEGHIYSLAAKEDLLYTGSDSKNIRVWKNMKEFTAFKSNSGLVKAIIISGDKIFTGHQDGKVRVWKINPKNPSVHKRSGTLPTFFDIFKASMKPSNYIEVKRKRTALWIKHVDAISCLSMNQEQGLLYSASWDRTFKVWRVENSKCLESVKAHDDAVNSVVASVEGLVYTGSADGTVKVWRRESSGKTVKHHFIQTLLTQECAVTALAVNKSGSVVYCGSSDGLVNFWEREKELTHGGVLKGHKLAVLCLTAAGNLVFSGSADKTICVWRREGNVHTCLSVLTGHTGPVKCLAAEEDKDSSTGDQRWVVYSGSLDKSVKVWSVSETAPDLRHMGNMQPGQGDSPWDSIPSAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGR1</accession>
    <name>A0A068UGR1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024654001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGR1"/>
    <dbReference type="STRING" id="49390.A0A068UGR1"/>
    <dbReference type="Gramene" id="CDP07399">
        <property type="protein sequence ID" value="CDP07399"/>
        <property type="gene ID" value="GSCOC_T00024654001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGR1"/>
    <dbReference type="OMA" id="CKEAFRH"/>
    <dbReference type="OrthoDB" id="625265at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF45">
        <property type="entry name" value="SNAKIN-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657962" evidence="2">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="107" mass="11508" checksum="2EA4CB48FD07631E" modified="2014-10-01" version="1">MAFPKAPMMMVIIIIASLVTLSLVYAAQVPQIDSSTGGRSLLQNNDIDCKSACDARCAETKRRNLCKRACGTCCERCHCVPPGTSGNEDVCPCYANMTTHGGRHKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGU3</accession>
    <name>A0A068UGU3_COFCA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025137001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGU3"/>
    <dbReference type="Gramene" id="CDP07765">
        <property type="protein sequence ID" value="CDP07765"/>
        <property type="gene ID" value="GSCOC_T00025137001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGU3"/>
    <dbReference type="OMA" id="CYSGREY"/>
    <dbReference type="OrthoDB" id="1688035at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGU3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33168">
        <property type="entry name" value="STRESS INDUCED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="116" mass="13452" checksum="A48F45C226338D30" modified="2014-10-01" version="1">MDMGARCSSGNGEVCCCCWCRSLSSRNYDRFVSHIIRPSSGSKAPIWRQLWTKMKNEKKRTFYRSTSTRFAYDPHTYSQNFDQGLTWADPDDISRSFSARFAVPSRIFDDKDVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGU6</accession>
    <name>A0A068UGU6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Factor of DNA methylation 1-5/IDN2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00025146001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGU6"/>
    <dbReference type="STRING" id="49390.A0A068UGU6"/>
    <dbReference type="Gramene" id="CDP07770">
        <property type="protein sequence ID" value="CDP07770"/>
        <property type="gene ID" value="GSCOC_T00025146001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGU6"/>
    <dbReference type="OMA" id="ALWITQE"/>
    <dbReference type="OrthoDB" id="1892195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080188">
        <property type="term" value="P:gene silencing by siRNA-directed DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045177">
        <property type="entry name" value="FDM1-5/IDN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005379">
        <property type="entry name" value="FDM1-5/IDN2_XH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596:SF65">
        <property type="entry name" value="PROTEIN INVOLVED IN DE NOVO 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03469">
        <property type="entry name" value="XH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Factor of DNA methylation 1-5/IDN2" evidence="2">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="306" mass="35063" checksum="4C5EE12EB7392C24" modified="2014-10-01" version="1">MSQDAVSCDNPANDPLELACIQQLATAGLILKLVEEQEKKVEVELRKMSELKGQLNTKDVEANSYQHAICVLRRFAHEDEEKMKQTQEELLQRVEEVNDLQTLNQHLIVKERATNDESTEARKELIVSLAHFLDDQSDIRIKRLGEIDILPMQIAVQRKFTTAKSFIEAARLCSLWQSKIENPEWHPFRIVGDTSKNLFVQEILDEEDEALVDLQMEWGGEAYAAVVTALKEMNECNPSARRITPELWNFTEGRRATLKEIVLHLINMLNPPQKRSRTGKIFSSLFSGVVSRSYNVVRPLKFPGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH93</accession>
    <name>A0A068UH93_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00024869001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH93"/>
    <dbReference type="STRING" id="49390.A0A068UH93"/>
    <dbReference type="Gramene" id="CDP07574">
        <property type="protein sequence ID" value="CDP07574"/>
        <property type="gene ID" value="GSCOC_T00024869001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH93"/>
    <dbReference type="OMA" id="ISQCVYY"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF45">
        <property type="entry name" value="PQ-LOOP REPEAT FAMILY PROTEIN _ TRANSMEMBRANE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP07574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="382" mass="43592" checksum="74C1F409F83164BA" modified="2014-10-01" version="1">MKPLKLSYCSVGQKPCVRWVEKYFKDCLCNLKDEISFAFGIASLVCWAVAEIPQIITNFKSKSADGVSLAFISTWIVGDVFNLVGCILEPATLPTQFYTAVLYAATTLVLALQCIYYDHIIRLWKGRKTKVNKDYNERSALKQNLHDRSSRDRRNAPIEVPRPRWRDFHFRSARSLAGSDTPPIQSYIKPKSGPPALEHQSESSSEDEEAIPPEFYQRPVSQPRLIPGPVGYGTFLAVSAYIPRGSKASQLYFVGRRLLEEKYELHGRAYGQWLGWLMAAIYMGGRIPQIWLNIKRGSVEGLNPLMFLFALIANAAYVGSILVRSSEWEKIQPNMPWLLDAVVCVALDLFIILQYIFYRFIKRKKSQRSEEHYEDCGTKLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHN1</accession>
    <name>A0A068UHN1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MLO</name>
        <name evidence="11" type="ORF">GSCOC_T00024267001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in modulation of pathogen defense and leaf cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MLO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHN1"/>
    <dbReference type="FunCoup" id="A0A068UHN1">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHN1"/>
    <dbReference type="Gramene" id="CDP07138">
        <property type="protein sequence ID" value="CDP07138"/>
        <property type="gene ID" value="GSCOC_T00024267001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHN1"/>
    <dbReference type="OMA" id="PVLMWIV"/>
    <dbReference type="OrthoDB" id="1388414at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHN1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF34">
        <property type="entry name" value="MLO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4 8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="589" mass="67039" checksum="64696CD11CB004F3" modified="2014-10-01" version="1">MAGGGGGRSLEQTPTWAVAVVCFVLVAISILIEHILHLIGKWLKSKHKRSLYEALEKIKSELMLLGFISLLLTVGQGPITKICISKEVGATWHPCNKKQEANLDQHSGVSHGEDGRRRLLSDDGARRILASGGADKCEAKGKVSFVSTDGIHQLHIFIFVLAVFHVLYCILTYALGRAKMSSWKAWEKETKTAEYQFSHDPERFRFARETSFGRRHLSFWSRTPFLLWIVCFFRQFVRSVPKVDYLTLRHGFIMAHLAPQSHANFDFQKYINRSLEEDFKVVVGISPPIWLFAVIFLLFNTHGWYSYLWLPFVPLVIILLVGTKLQVIITKMGLRIQERGEVVKGVPVVQPGDDLFWFNRPRLILYLINFVLFQNAFQLAFFAWTWYEFGLRSCFHEHLEDIIIRISMGVLIQILCSYVTLPLYALVTQMGSTMKPTIFNERVATALKNWHHTAKKHIKESKHSGLASPISSRAATPSHHLSPVHLLRRYKSELDSLQTSPRKSNFDVEQWDTESPSPSQFHQGSIDHVSSSQHQHNIELGFLDHDGTDVQGPSLSSQVAPLPEHEINTRLSNSGKSSEFSFIQRNASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHY5</accession>
    <name>A0A068UHY5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00024373001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739109">
        <property type="protein sequence ID" value="CDP07203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHY5"/>
    <dbReference type="FunCoup" id="A0A068UHY5">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP07203">
        <property type="protein sequence ID" value="CDP07203"/>
        <property type="gene ID" value="GSCOC_T00024373001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHY5"/>
    <dbReference type="OMA" id="LPKHDEY"/>
    <dbReference type="OrthoDB" id="1909330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHY5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044837">
        <property type="entry name" value="REM16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391:SF99">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS06G0194400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS11G0197600-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="176"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP07203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="274" mass="31740" checksum="C0B1A7E745E1F1BB" modified="2014-10-01" version="1">MVVSKKGALAYEERRHERLEQNKKKLEQLNLTKLSQALHSTISPKPSPMKKVKPKVARQPVDPSTIRRSSRVADKPPPNYKEIYLLFQLCNKRSVLRHFDRRSLPYFPGCSVVNLRSLYYLVLWQVPIEPLGRPRSYRYSRRDLSNRVYASDEDREYAHERAEVLQSGLDSKIPSFVKPMLQSHVTGGFWLGLPVQFCKTYLPKRDETVTLVDEQEEEYPTKYLAVKTGLSGGWRGFSIEHELVDGDALVFQLIEPTKFKVYIIRVNQAEDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKD1</accession>
    <name>A0A068UKD1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027714001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKD1"/>
    <dbReference type="FunCoup" id="A0A068UKD1">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKD1"/>
    <dbReference type="Gramene" id="CDP08669">
        <property type="protein sequence ID" value="CDP08669"/>
        <property type="gene ID" value="GSCOC_T00027714001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKD1"/>
    <dbReference type="OMA" id="HRFNQKF"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKD1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05472">
        <property type="entry name" value="cnd41_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000010">
        <property type="entry name" value="Aspartyl protease family protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000019">
        <property type="entry name" value="aspartyl protease family protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033873">
        <property type="entry name" value="CND41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051708">
        <property type="entry name" value="Plant_Aspart_Prot_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967">
        <property type="entry name" value="OS07G0603500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967:SF60">
        <property type="entry name" value="PROTEIN ASPARTIC PROTEASE IN GUARD CELL 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654967" description="Peptidase A1 domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="145"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="487" mass="52173" checksum="872EF70AF65F647B" modified="2014-10-01" version="1">MRTPTIALSLLLLLFSTFLTSTPTPTPTHKLDCQTFIPNSLPKPTQSPSWTSDGEPQTILSQETAAGTEFQSNNFSLELHHVDALSLSPHASPESLFNLRLQRDAFRAKSISDMASGRGRQGVGLGRMNFSSSVISGLSQGSGEYFTRLGIGTPPKYSYMVLDTGSDVVWIQCSPCKKCYTQADPLFDPSHSSSFAGVACASPLCRRLDSPGCNNRQKCLYQVSYGDGSFTFGEFSTETLTFRRVRVNNVGLGCGHDNEGLFIGAAGLLGLGRGKLSFPSQAGRRFGRKFSYCLVDRSSSSRPSSIVFGESSVSRTSVFTPLLTNPKLDTFYYVGLNGISVGGSRVPGITESHFKLDAAGNGGVIVDSGTSVTRLTRPAYIAMRDAFRAGASNLRRAPDFSLFDTCFDLSGKTEVKVPTVVLHFNGADVSLPASNYLIPVDGNGRFCFAFAGTISGLSIIGNIQQQGFRVSFDLAGSRVGFAPRGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULI6</accession>
    <name>A0A068ULI6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028616001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULI6"/>
    <dbReference type="FunCoup" id="A0A068ULI6">
        <property type="interactions" value="1532"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULI6"/>
    <dbReference type="Gramene" id="CDP09306">
        <property type="protein sequence ID" value="CDP09306"/>
        <property type="gene ID" value="GSCOC_T00028616001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULI6"/>
    <dbReference type="OMA" id="WPSSANT"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULI6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000175">
        <property type="entry name" value="54S ribosomal protein L51, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="119" mass="13646" checksum="CA9D7E5E7A32BF36" modified="2014-10-01" version="1">MALRGVWQLNKLIVSYCDWGGSSRGVRAFMESHLPAFKEISPQLEVVSELNRGQHPYLKGLYRNKNERVVSVKNMTPEDILLCATRLRNSLGRKVVKLKTRHVTKHPSVQGTWTTELKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULS1</accession>
    <name>A0A068ULS1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00028437001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULS1"/>
    <dbReference type="FunCoup" id="A0A068ULS1">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULS1"/>
    <dbReference type="Gramene" id="CDP09207">
        <property type="protein sequence ID" value="CDP09207"/>
        <property type="gene ID" value="GSCOC_T00028437001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULS1"/>
    <dbReference type="OMA" id="IMHPTVD"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULS1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20405">
        <property type="entry name" value="Tudor_Agenet_AtDUF_rpt1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054292">
        <property type="entry name" value="DUF7028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF12">
        <property type="entry name" value="GB|AAC80581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22970">
        <property type="entry name" value="DUF7028"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="838"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP09207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1211" mass="136942" checksum="27246FDAA457D1A7" modified="2014-10-01" version="1">MAALSDEAAAKKKRKRINGKKKILIHDKVEVRSTEEGFLGSWHAGTVVGCGELRRRIKYDEILNDDGSERLVEWVKVSPALDGLVRGNQATSNCCRGNIRPLPPSVDFQKWSLHYGQCVDVFVQDAWWEGVIFDHEDGSDQRKVFFPDMGDEVKAQIETFRITREWDDITDEWRPRGNWLLLELIEEVELEWPLLVSVKQIWYEIRVKMEFGKLKEWTSSSRDIWRQLLLQVLSTSYKLTVKQIFHELNSSENSTEEGQPLFEFSANALDAILDPESIFSDTMAIVPYGTNCQLETHAALSADLNPSEEQNAPNALACIGWVEMDNSTHSMKRPNELPCVQAPAFSGLPPNPDHSPEAGSGAKSGRCPTSSDKLNGKLKASGDRTKLQWLPAGIDMVPGTACCPGSVTDYIQKRKLNYKSRAASTLEVRMHISYLGWKIQFARDKAVTRMRYISPEGEIHYSLYQVCLRLQPGSDVPSRICQDDESNSDYPVESSVSSSLTVIPKADTGALKVLSCSEPVYFERDNCPEAVLNYSNWGGTTYHGQNGAKGGIMALKAKRHLSFLGWKFYLEPKGFKKEMRYGSPCGKKFYSLRSACHWCVTEGRIHLNPSPPSNAMVSEGHVNDDLSKQLLIESSSKTSQPKQLAQQGQVKCHGIRGPERKRNHCLLQQSLAALHTGPQNEDSYLLDDVKESQASAKQRDDVNAEMSSCVLRSSKRARQSVVSPSIHQTPRTTLSWLIDNNVVLPRAKVHYRGKKDGRVMKEGKITREGIKCTCCQKVFTLSKFEAHAGSNYHRPSANIFLEDGRSIFQCLLKLKGETNKRKIRSEPREMKGHRLHNDHICSVCHYGGELVLCDQCPSSFHTICLGLKEVPDGDWFCPSCCCGICGLSRLNEDTGRPVDDRLINCGQCEHQYHIECLKKKGLVKHDCHPERNWFCNEKCEQIHLSLHNLLGKPIPVGHDNLTWTLLKYKNAEDSDQEGLDNEHLMESYSKLNIALSVMHECFEPMKEPRTKRDLVEDVIFSRWSELNRLNFQGFYTVVLERDDDLITVATVRVYGEKVAEIPLVATRFQYRRLGMCRIMMNELEKKLIELGVQRLVLPAVPSVLSTWETSFGFSRMTESERLNFLDCTFLDFQGSHMCQKLLKNTQCTELSQLTGKLVQQKLSPHSGEKDNDLEARGAASEVLQAEQVEDIEVVDQGAAEYVDFLFSYEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM34</accession>
    <name>A0A068UM34_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028586001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM34"/>
    <dbReference type="STRING" id="49390.A0A068UM34"/>
    <dbReference type="Gramene" id="CDP09289">
        <property type="protein sequence ID" value="CDP09289"/>
        <property type="gene ID" value="GSCOC_T00028586001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM34"/>
    <dbReference type="OMA" id="LQWVIAP"/>
    <dbReference type="OrthoDB" id="66678at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM34"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36893:SF1">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36893">
        <property type="entry name" value="OS01G0275950 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655026" evidence="2">
        <location>
            <begin position="21"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="946" mass="106243" checksum="639E81137EB1D123" modified="2014-10-01" version="1">MSKYSSIIFASIILSLSCSAVSDLSFWHLQQYVRQSDRKFEQKTNRFWEFHEQSNSWVEVELPFDLVSCVNDTCTRVGSVDHQTMDKIEDTEELDVPESKRSSEKEDCLKAGVGENSNAVLPFRKRVSLTKMSDTSIWITGPSGSIYERFWNGLQWVIAPHDLPASAGYAISVFIVNQIILALSEAGNLYQMQLNENAHPVWIDFTPLINNSTSHETGQRFPARVISGVTSEDRERLYLCTKNRSLIELIGTEPTRWKNHGRPPGADVEAIVDATSVRPEAVFTVSAAGDLYEYDQSSKPAWKKHIQKEGSELDLSLAPLKGCSFHGLNGPTSVSIFLLTKGGDLVERQFQQRKWKWVPHGSPEDHFLTSITCNPQDEPNENLNTMFLTTAAGLVFEYRIPKQSGASQENQILEHWVNHIHPSNAKIAKRITGLQLQVGRMIFPLDDGRLSELHLAGIGGESSGPSQQINARRRVSPKYVWSILDAPETEGWNAEYCTEEYGPTNCISGMKEETNDEDLTGLISRRRKGISSQQNYLLLGISGSSSTKTLEDLSIADHSITKNFRLRAMHGGKSFFLITDEGLTFEYLSAENVWFWLRHEHSTAIRGAVGNYNGSLYLIDEYGSLFIRERSGNELAWINCTAIKKGRQVIGGPPWDGIPGKTQKVTATDALFFVSRSGRLLQLTVALRKFKWKDCRNPPNTKIACIADQEALREKIVFVVGRNGRLYQYNKVTELWHEHYQSQHLVLSRLPGTAMRPSPLSLKGSLFMLSENGGLVEYHWNQLDGWNWVEHGTPNSNVTLVGSPGPCFEGGQLFLIGSDGNVYLRFLDQATWKWKNCGFPYTETKVDADQKQIGEGNGNKDICINEEIETSFEKLAENLQAINKNCDPKVESTRPISFAETSVIFELRDGRLAELQKTGDANWAWSRSIGTPTSLCLANYWTTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM94</accession>
    <name>A0A068UM94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028697001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM94"/>
    <dbReference type="FunCoup" id="A0A068UM94">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09364">
        <property type="protein sequence ID" value="CDP09364"/>
        <property type="gene ID" value="GSCOC_T00028697001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM94"/>
    <dbReference type="OMA" id="CSIMLTW"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM94"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021940">
        <property type="entry name" value="CER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12076">
        <property type="entry name" value="CER1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Very-long-chain aldehyde decarbonylase CER1-like C-terminal" evidence="7">
        <location>
            <begin position="442"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="70586" checksum="43E75657D0430A1D" modified="2014-10-01" version="1">MATTPGLLTDWPWTPLGRFKYVVLAPWVAHSIYSNATKGESERDLTNLLILPFLLWRMLHDQIWISISRHRTANGKNRIVDKTIEFEQVDRESNWDDQIILNGILFYIFNNLLSNASRLPLWRTDGVILTSLLHSGPVEFLYYWLHRALHHHFLYSRYHSHHHSSIVTEPITSVIHPFGEHIAYFLLFAIPILATWYTGTASLASMFGYITYIDLMNNMGHCNFELIPKRLFSIFPPLKYLMYTPSYHSLHHTQFRTNYSLFMPFYDYIYGTMDKSTDSLHETSLQREEDAPDVVHLTHLTTPQSIYHIRLGFASVASKPEGSTWYILLMWPVTLWSAIINSIYGRTFILERNKLEKLKLQSWAIPRYNVQYLKKWRSRAINGLIEKAILDAEAKGTKRKELNKNGEFFMRRYPKLKLRVVDGSSLAVATVLNNIPKGTTEVLLVGNLTKVARSVALALCERGIQVNISSQYEFEKLKQSVASQSNLVVLSKSVAAYKTWLVGDGLTEKQQLNAPKGALFIPFSTFPPKKVRSDCSYLHTPAMLAPASLQNLDSCENWLPRRALSAVRAAGIVHALEGWTEHECGENMLNVEEVWQAALKHGFRPLGSPSNWSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMA6</accession>
    <name>A0A068UMA6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00030069001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMA6"/>
    <dbReference type="STRING" id="49390.A0A068UMA6"/>
    <dbReference type="Gramene" id="CDP09660">
        <property type="protein sequence ID" value="CDP09660"/>
        <property type="gene ID" value="GSCOC_T00030069001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMA6"/>
    <dbReference type="OMA" id="TYICIVE"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMA6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031:SF37">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="123" mass="13992" checksum="8D6BCDC8451646E8" modified="2014-10-01" version="1">MYKSRLQEYTQKSCLRPPVYTIVKEGAGHSPNFRATVLVDGKKYASEGTFQRRKSAEHNAAMIALQSIQNKMNNDGYPINPKDTTLCKSILNEYALKMHLEHPAYYTVQPQGLIPVFASTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN48</accession>
    <name>A0A068UN48_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNARE-interacting protein KEULE-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030362001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN48"/>
    <dbReference type="FunCoup" id="A0A068UN48">
        <property type="interactions" value="3031"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN48"/>
    <dbReference type="Gramene" id="CDP09881">
        <property type="protein sequence ID" value="CDP09881"/>
        <property type="gene ID" value="GSCOC_T00030362001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN48"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN48"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76143" checksum="97348AF0341463DA" modified="2014-10-01" version="1">MSMSDSDTSSQGGEYKNLRQISRERLLYEMLRSTKTGDSKSTWKVLVMDKVTVKIMSCACKMADITEEGVSLVEDIHRRRQPLPTMDAIYFIQPTKENVVIFLSDMAGRSPLYKKAFVFFSSPVPRELVIQIKRDTSVLSRIGALREMNLEYFTIDSQGFITDNERALEELFGDEESSRKVDACLNAMATSIATVFASLREFPFVRYRAAKSLDPTTMTTFRDLIPTKVAAAVWNCLMKYKANLPNYPQTETCELLILDRSVDQIAPVIHEWTYDAMCHDLLNMEGNKYVHEVPSKTGVPERKEVLLEDHDPIWLELRHSHIADANERLHEKMTNFVTKNKAAQMHQGSRDGGELSTRELQKMVQALPQYSEQIEKLSLHVDIAGKINRIIRELGLKEVGKLEQDLVFGDAGTKDVINFLRTNQDVTRENKLRLLMIYAAVHPEKFEGDKVAKLVELARLPQEDMNAVYNMRLLEGAADSKKSSVVPFSLKFDVHKKKHAARKDRPGEEVAWQLSRFYPMIEVLIEKLSKGELAKNDYPCMNDPSATFHGNSNSASVRTGEIPAAHSVRSRRTATWARPRNSDDGYSSDSILKHASSDFKSMGQRIFVFIVGGATRSELRVCHKLTTKLKREIILGSSSLDDPPQFITKLKLLAAQDLSLDDLQISLDDLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UND8</accession>
    <name>A0A068UND8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00028332001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UND8"/>
    <dbReference type="STRING" id="49390.A0A068UND8"/>
    <dbReference type="Gramene" id="CDP09128">
        <property type="protein sequence ID" value="CDP09128"/>
        <property type="gene ID" value="GSCOC_T00028332001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UND8"/>
    <dbReference type="OMA" id="QDCDPRL"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UND8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000016">
        <property type="entry name" value="probable serine/threonine-protein kinase At4g35230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000154">
        <property type="entry name" value="probable serine/threonine-protein kinase At4g35230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000069">
        <property type="entry name" value="probable serine/threonine-protein kinase At5g41260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045845">
        <property type="entry name" value="BSK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE BSK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BSK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1070">Brassinosteroid signaling pathway</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="59"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP09128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="489" mass="54744" checksum="008FA3B52D762BCA" modified="2014-10-01" version="1">MGARCSKLGFCWWPSNLKSNVPYSSDLEKCGENERMKLPAFKEYSLDELKVATSGFSVENIVSEHGEKAPNVVYKGQLEDDGSWIAVKRFNKSAWPDSRQFLEEAKAVGQLRSERLANLIGCCCDGNERLLVAEFMPHETLSKHLFHWETQPLKWAMRLRVALHLAEALDYCSSKGRALYHDLNAYRILFDQDANPRLSCFGLMKNSRDGKSYSTNLAFTPPEYLRTGRVTAESVVYSFGTLLLDLLSGKHIPPSHALDLIRGKNIQMLMDSCLEGHFSNDDGAELVRIASRCLQYEPRDRPNAKSLVTSLAPLQKEIDVPSHILLGITHETSSPVQTSKLSPLGEACSRVDLTAMHELLEKVGYKDDEGVANELSFQLWTSQIQETLNSRKRGDNAFRAKDFATAISCYTDFIEGGNMVSPTVLARRCLCYLMNNRPQEALADAMQAQVTSPDWPTAFYLQAAALFSLGMNSDAQETLKDGSSMENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNG8</accession>
    <name>A0A068UNG8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030679001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNG8"/>
    <dbReference type="Gramene" id="CDP10080">
        <property type="protein sequence ID" value="CDP10080"/>
        <property type="gene ID" value="GSCOC_T00030679001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNG8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33659">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33659:SF11">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657835" evidence="2">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="6357" checksum="B6296C0A3A237288" modified="2014-10-01" version="1">MAEVSIAKALVMMVVVLMAVVAAASAQESPSPSPDAGAGFSLPVSGAMVAVSLVLSSVALLRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNM4</accession>
    <name>A0A068UNM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPX2 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030331001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNM4"/>
    <dbReference type="FunCoup" id="A0A068UNM4">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNM4"/>
    <dbReference type="Gramene" id="CDP09854">
        <property type="protein sequence ID" value="CDP09854"/>
        <property type="gene ID" value="GSCOC_T00030331001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNM4"/>
    <dbReference type="OMA" id="MEVEQVF"/>
    <dbReference type="OrthoDB" id="1684416at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF15">
        <property type="entry name" value="OS06G0130200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 central" evidence="2">
        <location>
            <begin position="256"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="513" mass="58609" checksum="B4FEE6C8B47E7C46" modified="2014-10-01" version="1">MDEEMEESEIYTFTAVEIDLDYEFDAVRYFDFSRQESLAEAHEAELWFETATTYPPSPFVARLFNVNDGLLENVNTSPKPKHVEEANMLESDSDIEVDEETSAVDKDGGQKEFNSRGTSASLRNSNQQRFQNHQQLASGLTFYNHMKKDSLKAKTKSSTKPYLSRTSTLMKPTASQLAKQNEPRQMYSSRFQRQLVDKNEKSTNNSFGVEIQAAKRQKLEGGHLSKVIDTKHQVNFVHKEPKRDGIVVGNTMQTKLRITIPREPDLETTYRAHRTRPKTVEEPQSLTSTVHRFKALPLNRKILEAPSLLAPKRSTPRVPEFREFHLKTSERAMQHTAIASVSAASFSNSNKEVESRNSTSQQCRDESRRCNVVDTSKERSELSHNFKALPLNRKILSSKGDIGVFRNSKREITVPMEFNFRTEKRVQHNPPIELFNKLSLTSEPKSKIKQPHPANLPAKGSKENRWDSFWEEQQVKHDMKEKLPLNGGKQFGNNLKKADDGLVSGINRSLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNT0</accession>
    <name>A0A068UNT0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Laccase</fullName>
            <ecNumber evidence="4 14">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00028501001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Secreted</location>
            <location evidence="2 14">Extracellular space</location>
            <location evidence="2 14">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 14"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UNT0">
        <property type="interactions" value="3451"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNT0"/>
    <dbReference type="Gramene" id="CDP09253">
        <property type="protein sequence ID" value="CDP09253"/>
        <property type="gene ID" value="GSCOC_T00028501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNT0"/>
    <dbReference type="OMA" id="FWRTRNV"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNT0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000007">
        <property type="entry name" value="N-alpha-acetyltransferase 25, NatB auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF68">
        <property type="entry name" value="LACCASE-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 14" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="1024"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="1153"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="1405"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP09253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1557" mass="175030" checksum="C16F61F9FC691977" modified="2014-10-01" version="1">MASKFGLAGGIPERRVRPIWDAIDSRQFKNALKHCSALLSKYPNSPYALALKALILERMGKAEEALSVCLNAKDQLYTNDSVLIDDLTLSTLQIVFQRLDHLDMATSCYEYACGKFPNSLELMMGLFNCYVREYSFVKQQQIAIKMYKVVGEERFLLWAVCSIQLQVFCGNGGEKLLLLAEGLLKKHIASHSLHEPEALSVYISLLEQQSKFGDALEILAGKLGSLIMIEVDRLRLQGRLLARAGDYSEAADILQKVLEQCPDDWEYFLHYLGCLLDDGSSFFLGNGGNSIYPPKHVGCKNLDLPDEVFNTRISRASVFVEKLMAECDNASIRSPHLANLEIQKRKLIYGKGDPGKLVEGLMQYFSRFGHLACFTSDVEAFLLFLDDPNKSDVLEKLKGCELTSSSQTKALGQAITIFKVENLIGNMFSLPVCELEGLAVRMADMYCKNLPLSKDLDLQENMHGEELLSMACNVLVQLFWRTRNVGYLLESIMVLEFGLTIRRYTWQYKILLLHLYSYWNCLPVAYDWYKSLDVKNILLETVSHHILPQMLASPLWSDLNDLLRDYLKFMDDHFRESADLTFLAYRHRNYSKVIEFVQFKERLQRSSQYLVAKIEAPILQLKQNANSIQEEECILESLKNGNHFVELSNELGNKLLTFNEDLQLRPWWTPTFDKNYLLGPFEGVSYYPRENLIKQTEENVLKNIEKRSLLPRMIYLSIHCASSSLKEHTEANGSAFDPKLSLELKVLLERYARILGFPFQDAIELVLGVSSGQKPSEALSSDLIGWINFVVFLNAWNLNSREIGFSNNDKPRPSTWHLVNSLLKKYIIEKMRSTGPLLSSPGGDLPMLVQLVTEPLSWHSLIIQSSVRSSLPSGKKKKKGGVTEQTNSHHSHEIQDSIQSLCDAMKEVTGWLSEQINKLDDVKFETIFSLLQVNGEDQGPGRILHMFETLISSVDNTALGDRISQALQSWDAAEVVRKVGAGQSSVLSHVVKPWSSGFLLGFLAILAAVASHPNGEIHYHEFVVQAKSVTRLCSTHSIITVNGQFPGPTLAVRNGDTLVIRVLNRAPYNVTLHWHGVRQMRTPWADGPEYVTQCPIQPGGTYTYRFTIENQEGTLWWHAHSRWLRATVYGALVIFPKQGFAYPFAKPKLDVPIILAGEWWKRDIISVMRQALFTGAAPNVSDAYTINGQPGDLYRCSNRGTFKVYVNSGDTVLLRVINAALNQQLFFTIANHQLTVVGADASYLKPFSTRVIMLGPGQTTDVLLNANQRAGRYYMAARAYATAQGAPFDNTTTTAILEYRNSRTGSFSRPILPQLPAFNDTATTTAFTSQLRSIPSNYKVPTQIDDSLFFTVGLGFVNCNPGPRCQGPNNTRFAASMNNVSFVLPNRTSLLQAYYQNIPGIYTLDFPPVPPVQFNYTGTVPRSQWQPVFGTKLYKLKFGANVQIVLQDTGIFSTEDHPIHLHGYHFFVVGQGFGNFNPQTDTGNFNLVDPPSRNTIDVPVGGWAVIRFVADNPAGVWLFHCHIDSHLTWGLAMSFIVENGRGELQTVEPPPADLPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNT3</accession>
    <name>A0A068UNT3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00030704001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNT3"/>
    <dbReference type="FunCoup" id="A0A068UNT3">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNT3"/>
    <dbReference type="Gramene" id="CDP10096">
        <property type="protein sequence ID" value="CDP10096"/>
        <property type="gene ID" value="GSCOC_T00030704001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNT3"/>
    <dbReference type="OMA" id="WKIKGGD"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNT3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000019">
        <property type="entry name" value="Cytochrome P450 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF17">
        <property type="entry name" value="3,9-DIHYDROXYPTEROCARPAN 6A-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="519" mass="58714" checksum="30BCEAF579E1DA1D" modified="2014-10-01" version="1">MANSSDILFYGLLFFIWFATTTFFRYVLKQRKNGSKQIRHPPSPPSLPIIGHLHLLGSVASKSYQTLANQYGPLIRLRVVSSSVVVVSNAAIAKEFLKNNEMNFVSRPQFGAADFNIYAGSEFVNAEYGPYWRFMKKLCMTELLSVTQVNRFVDIRRQEMMKLLKILVGFSEERKACDLGVELMTTTNNVISRMAMSTRCTPGLDEGRRLWEFVKEIFELSPKFALGELFGPIGKLDLFGYGKRVKALLSKFDSLVEKIMVEHENELNSSNKERKDMMDILLEIHGDKKAEVKLSRTDIKSFLMELFMAGTETVSVALTWTLAELINHPKVFRQLRDEINTVVGSKRLVQEFDVPKLLYLQAVVKESLRLHAPAPLMFRRCGEDCKINGYDILANERIAFNVFAIMRDPSSWDNPLEFQPERFMVGSKVAYDDYQMDLKGQNFNVFPFGSGRRGCPGASLSLAVVHSAVALLVQCFDFTVHGGEKIKMEEGSGLSAGLAHPLMCYVTPHLNPLELLHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR79</accession>
    <name>A0A068UR79_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RPM1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00030725001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP10113">
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        <property type="gene ID" value="GSCOC_T00030725001"/>
    </dbReference>
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    <dbReference type="OMA" id="SHECNIG"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR79"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="174"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="440"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="589"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="108946" checksum="04E93B86CA161218" modified="2014-10-01" version="1">MAETILPFVLRQLSTFLREEGQLLGGLRQEVQFIMDELGHIRAFLREAEEKEEDAQPRLQEWIKQVREVAYDIEDFLDEFGARFPRHPTTGFHGSVRRTFSSIKNLKARHRGASKIQSIKSRIKSISEGHQRYQSEFGISTQASNSLSAANNTTWRYSRDDALLVEEAKLVGIEQPKKHLISQLLKGDDCQLKVVSVVGMAGLGKTTLVKKVHEDPDVISHFPVRAWVTVSQTCDFQDLLKDLIRQLCKEGKKPVPQLIESMTTAELKEFIKNFLQQAGRYAIVFDDVWDVEFWNTIKFALPESSRGNRVMLTTRKADVASASCIESRGLVYKMEPLSIEDSWTLFCNKIFNGDNCPGHLMDAAKGILDKCAGLPLAIIAISGLLALKDVNRIEEWEKVRRSLGGELEGTGKLDRVKKILCLSYNDLSWQLKTCLLYTSVFPEDYKIQGVRLINLWIAERFVEWREGMNIEDIAWGYLSELVNRSIIQVTRVFYEGIPRHCQIHDLWREIIISKSREQNMATITAGQPTRWPSEKVRRLVVHSSRSNNTQHHQQRPNYCFDCLRSFITVGSMDPPLFKIGQATLEKIPNEIFNLFHLNYLNLFGTRVERVPKAIGKLQHLEYLNLGNTRVRELPMEILKLQKLWFLKVFQLVDSSDDDYGFHGFKAPSNMGGLLGLEILECIDASGESTIIQEIGKLTQLRELIITKLKREDGKELCSSLANLTNLRELTVNSVGKGDDHEILDLNHHYSSLSSSSSSSSCSFLQSLHMLILLGHLEKMPKWVVHLHSLVRIDLNWSRLRGEEDPLESLQYLPNLHSINFCGSYQGEGLCFKVGGFLKLKRLHLKSMEGLRWMRVEEGALPHLQRLILEKLPLLEELPLGIQHLSHLQQLFLYEMSSQMMEKMENQKEESEGYTRIEHIPEIVLGYNTNDGKWRHRRLWAKNKKTYNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URC8</accession>
    <name>A0A068URC8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030775001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URC8"/>
    <dbReference type="STRING" id="49390.A0A068URC8"/>
    <dbReference type="Gramene" id="CDP10153">
        <property type="protein sequence ID" value="CDP10153"/>
        <property type="gene ID" value="GSCOC_T00030775001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URC8"/>
    <dbReference type="OMA" id="ACFSIDF"/>
    <dbReference type="OrthoDB" id="1483207at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288:SF17">
        <property type="entry name" value="CYSTEINE_HISTIDINE-RICH C1 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288">
        <property type="entry name" value="PHORBOL-ESTER/DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="375" mass="42316" checksum="FF6DCA966D00C20E" modified="2014-10-01" version="1">MEKPLQKLLIQHFSHEHLLERRLFPPEGNCICFGCKLQILPGKHGYRCRKCPFYLHQVCYSMPQKIQHPVDPNHHLTLLAIPSDFDKAIDCEACEQTIAGFYYNCATCGTFYHMLCLATPLSVKLPVHPHTLKLEFSPPYKFQCDLCDMSSHRGWLYRCGFCEFDVHISCAIMNSQAMLQLQPQTRVLEIDGRTDADSKRHELMALVLKGIAGLQGQENFPSQSEYYQPSPLSEYAPTPSFQLSEACFSIDIERSFIHDGLESKEADFHQVQLQESKETKNIAYVVLTKGDVHDPKQPNPVVTPAKNPSDGSRIGTPQKGQKPAIRSHVWVELGQENAKANASNDNAGLVHQTQEQVSIILSINITEINGMQNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USM6</accession>
    <name>A0A068USM6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BREVIS RADIX N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00033326001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USM6"/>
    <dbReference type="STRING" id="49390.A0A068USM6"/>
    <dbReference type="Gramene" id="CDP11219">
        <property type="protein sequence ID" value="CDP11219"/>
        <property type="gene ID" value="GSCOC_T00033326001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USM6"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044532">
        <property type="entry name" value="BRX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027988">
        <property type="entry name" value="BRX_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058:SF2">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13713">
        <property type="entry name" value="BRX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor BREVIS RADIX N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="114" mass="11860" checksum="C472681D5297839F" modified="2014-10-01" version="1">MLTCVACSKQHLNAASLPQPQHDGDNDAAAATISTPSTRQAIKALTSQIKDIGIKASGTYKNCKPCSGSSNHHNNRGNDYADSEPGSVSGRYHFSYARAAAAAAGSSNSTPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTL4</accession>
    <name>A0A068UTL4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033930001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739140">
        <property type="protein sequence ID" value="CDP11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTL4"/>
    <dbReference type="Gramene" id="CDP11589">
        <property type="protein sequence ID" value="CDP11589"/>
        <property type="gene ID" value="GSCOC_T00033930001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTL4"/>
    <dbReference type="OMA" id="FYMNHHS"/>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTL4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13079" checksum="1FB806CE7B94DB47" modified="2014-10-01" version="1">MNFRSVEEFWLFYMNQHSKPATRCWHFVSTLCSIICLTYSMGFQLVVCDPCALVGTWHGIAIFFVEGNVPATFGHHFWSLLCDFKMFRLMLTGQMDREIKRLSKRLVLQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUJ7</accession>
    <name>A0A068UUJ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00035477001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUJ7"/>
    <dbReference type="FunCoup" id="A0A068UUJ7">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUJ7"/>
    <dbReference type="Gramene" id="CDP12096">
        <property type="protein sequence ID" value="CDP12096"/>
        <property type="gene ID" value="GSCOC_T00035477001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUJ7"/>
    <dbReference type="OMA" id="IGSQWTV"/>
    <dbReference type="OrthoDB" id="361580at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUJ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592:SF24">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="41966" checksum="A885AB3ADA2A3EE5" modified="2014-10-01" version="1">MCSIANAPSSRLRAFPPPPINLMLSSTSLNCPKTFPRRPLRSIPAPPFFRASKLSPNIKSVAPLTHTFRPSCTKKWKISCFRHEECSSAGINRESLGEEIRHENLRKTEVEKPSTGKRSWISSLGEWVDAVLRVIGKPWTVPWTAETILQVTLLWVVSFWFVGSWMIPFGAHMVGFNKESLTYRGQALFSLLTDVTEGLAGILILHRCLSRFRPLPSDWFKFSLKGKWLFDVVLGCLMFPLVNRLSQFNLDLLPVLPSTPVTLSTVEQSIMARDPVAMGLYALVLVVCAPLWEEIVFRGFLLPSLTKYMPVWCSVLMSSVAFALAHFNVQRMLPLIFLGVVMGVIYARSRSLLPSILLHSLWNGFVFLDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUK1</accession>
    <name>A0A068UUK1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00033443001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUK1"/>
    <dbReference type="Gramene" id="CDP11293">
        <property type="protein sequence ID" value="CDP11293"/>
        <property type="gene ID" value="GSCOC_T00033443001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUK1"/>
    <dbReference type="OMA" id="SAESFMM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUK1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000317">
        <property type="entry name" value="Inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF602">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655114" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1969"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="973"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="2024"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1001"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="2052"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2312" mass="255076" checksum="08D733E01DF03172" modified="2014-10-01" version="1">MEKFHNLSPLGLVLLCFLSASFAMFPTNITTDQSSLLALRAHISFDPLQILAKNWSVGSSVCDWIGVSCGSRHRRVTALDISNMGLTGIIPPQLGNLSFLVSLDLSANNLHGELPHEFVGLRRLKLLNLSVNNLEGELPQWIGSFPQLRRLSLRNNSFTGLIPSSISNLSKLESISLSYNPLQGNIPIGIFNISSLQVINLINNSLSGVLPSDMCYHLPRLSYLQLSMNKLNGQLPSSNLAQCSELRALSLSINEFGGSIPKEIGALKKLEELYLGHNYLEDCFWWIGSFPQLRLLSLSSHSFTGLLPSSISNMSKLEEISLSYNLLAGDIPTGIFNISSLQMIDLANNSLSGVLPSNMCYHLPGLSFLGLSDNKLYGQLPSSNLAQCSELQVLSLSYNEFGGSIPKEIGALKKLEELYLGHNYLEELLPKIFRILDLNLLIFIPFHFAGQIPKEIGNSTMIKIQNFASNNLTGVIPREIGNWYFLQQLEMEFNSLTGSIPIEIFNLSKLSIMSVTQNQLSGNLPSTFGYRLPNLEHLYLDINDLFGVLPSSISNSSNLRHIEFGGNKFTGPIPTSMGDLRFLEVLSLSDNFLVSDSSSPELTFITSLTKCQYLSILDLSDNPLNGIIPDSLGNLSNSLERLYVAGCKIKGSIPDGIGNLRSLILLDLSNNDLTGSLPATIIDLQKLQYMDLSMNNLISRVPLHLLCALHNLDTMNLGQNQFMASIPKCFGNLTSLRHLNLSHNRLYSAPPEEIWNLKDLLELDLSSNLLSGSLPYAITNMKMANWVNLSTNQFSGGIPDSIGDMQNLQNLSLAHNRFEGSIPESIGKVFSLESLDLSHNFLSGSIPMSMENLRYLKYINLSFNNLSGEIPSKGPFTNCTAESFASNQALCGAQRFHVPPCPSISAHKLRTKKLHRTIFISLGVIIAVGALSFGFVYLRYQKKDEFSSGADLSLVAMPERISYFELVQATNGYNESNLLGTGSFGSVYRGTLDDGRVVAVKVFNLQVDGAFKSFDVECEVLRNLRHRNLTRVISSCSNPEFKALVLEFMPNGSLEKWLYSHNYFLDIIQRLDILIDVAGALQYLHCEYATLVIHCDLKPSNVLLDQDMVAHLSDFGLTKLLGEENSITYTETLATLGYLAPEFGLEGLVSAKCDIYSFGIMIMVVFTRTIPYSEMFGENLSLKSWVANSIPDGLANVIDANLLKESHECIGRKLSCIASIMKVALGCTMESPKERSSIQDVLVTLKKIKLQFIKLSPLQILQPGLGTITEQSLAMEKFHNLSPLGLVLTCFLSASLAMFPSNITTDQSSLLALRAHISVDQILAKNWSVASSVCDWIGVSCGSRHRRVTALNISNMGLTGIIPPQLGNLSFLVSLNMSANNFHGELPHEFVGLRRLKLLNLSVNNLEGEFPHWIGSFPQLEEISLSYNLLQGNIPIGIFNISSLQIIALSNNGLSGVLPSDMCYHLPGLIRLSLSKNKLYGQLPSSNLAQCSELRVLSLSFNEFGGSIPKEIGALKKLEGLYLGHNYLEEIGNWYLLQQLDMEFNSLTGSIPIEIFNLSKLSVMSLLRNQLSGNLPSTFDYRLPNLEHLYLSNNHLSGALPSSISNSSNLRLIEIGDNKFTGPIPTSMGDLRLLELLDLAINNLVSDSSSPELSFITSLAKCKYLAILFLGGNPLNGIIPDSVSNLSTSLEQLYVPYCEIKGSIPDGIGNLRSLILLDLSNNDLTGSLPATMKDLQKLQYMDLSMTKLISRVPLHFLCALHNLDTMNLGQNQFMASIPKCFGNLTSLRHLDLSHNRLYSAPPEEIWNLKDLLMLDLSSNLLSGSLPYAITNMKMANWVDLSTNQFSGGIPDSIGDMQNLQNLSLAHNRLQGSIPESIGKVFSLESLDLSHNFLSGSIPMSMENLQYLKYINLSFNNLSGEIPSKGPFTNCTAESFASNQALCGAQRFLVPPCPTISAHRSRTKRVRRTIYILLGVIIAMGALSFGFVYLRYRRKDKLPNGANLSLVAMPERISYFELLQATNGYNESNLLGTGSFGSVYRGTLDDGRVVAVKVFNLQVDGAFKSFDVECEVLRNLRHRNLTRVISSCSNPEFKALVLEFMPNGSLEKWLYSHNYFLDLMQRLDILIDVAGALQYLHCEYATPVIHCDLKPSNVLLDQDMVAHLSDFGLTKLLGEENSITYTETLATVGYLAPEYGLEGLVSAKCDIYSFGIMMMEVFTRTNPNSEMFGEKLGLKSWVANSIPDGLANVIDANLLKESDECIGEKLSCIASIMKVALGCTIESSRERSSIQDVLVALKKIKLQYMSSQNSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV09</accession>
    <name>A0A068UV09_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00033743001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV09"/>
    <dbReference type="FunCoup" id="A0A068UV09">
        <property type="interactions" value="2905"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UV09"/>
    <dbReference type="Gramene" id="CDP11473">
        <property type="protein sequence ID" value="CDP11473"/>
        <property type="gene ID" value="GSCOC_T00033743001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV09"/>
    <dbReference type="OMA" id="IVQPHPN"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="456" mass="50380" checksum="486D6870C4900214" modified="2014-10-01" version="1">MESLRFHDGNITDLIDSRILGLRSDITHCLQVHSSMVRRLFLERELEGHRGCVNAVAWNSQGSLLISGSDDTQINIWSYSSRKLLHSIETGHSTNIFCTKFVPETSDELVVSGAGDAEVRLFNLSRLSGRGLDENMITPSAIFQCHTRRVKKLAVEVGNPNVVWSASEDGTLRQHDFREGASCPPAGSSHQECRNILLDLRWGAKKSLADPPKQSLALKSCDLSFTRPHLLLVGGSDAFARLYDRRMLPPLSSSEKKLPPPPCVGYFCPMHLSDRGRSSIHLTHVAFSPNSEEVLLSYSGEHVYLMDVNPATGSSMRYTVGDITKLTSFAPILNGVELQQSFPRVCSNGSSKGHVAARLDKCRKLIQFAGKSLKGETSSYDGIEACNEVLDGHGHEIGPSLMLECLCIRAALLLKRKWKNDVHMAIRDCYRARKINSSSLKALLCMSEALFQASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVG1</accession>
    <name>A0A068UVG1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00033980001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739141">
        <property type="protein sequence ID" value="CDP11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVG1"/>
    <dbReference type="STRING" id="49390.A0A068UVG1"/>
    <dbReference type="Gramene" id="CDP11613">
        <property type="protein sequence ID" value="CDP11613"/>
        <property type="gene ID" value="GSCOC_T00033980001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVG1"/>
    <dbReference type="OMA" id="SHEESWK"/>
    <dbReference type="OrthoDB" id="3027644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="231"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="313" mass="35908" checksum="AF77C03FC8B11FAD" modified="2014-10-01" version="1">MTGMGKTTLAKNLYNHPRVANHFHAHAWCSVFQEYEKRELLLEIWSNIRVPSDNICQMDDEDLALELYQQLKRSAYVIVMDDVCNIAVLMDLEGSLPDDGHGSRILIMSRLHDLAAIAEFDTVSHSLILSHEESWKLWQMRTFPDRNCPDELLGFGKKIAENCKGLPLAIIAIPGILKKTEKQQNKWKEVADNLSSLVVEIPESWCKEILQLSYHHLPAHLRTCFLYLGAFKEDKDILISKLTWLWVAECFVQMTELKCSDDAAEDCLMDLVDCILVMIQKGDLMKGAIHAMFMICFVICAFQKQRKRTFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWI1</accession>
    <name>A0A068UWI1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00037385001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739154">
        <property type="protein sequence ID" value="CDP12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWI1"/>
    <dbReference type="Gramene" id="CDP12751">
        <property type="protein sequence ID" value="CDP12751"/>
        <property type="gene ID" value="GSCOC_T00037385001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWI1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658029" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR608264-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="22484" checksum="4EA942DB7B2EED8E" modified="2014-10-01" version="1">MISLAFFKASFLLQISIIASFLLAAYAGNFYQDVAQTFGDQRFNILEGGQLFMLSLDKTSGSGFQSKNEYLFGRFNMQLKLIPGNSAGTVATFYLSSQGQGHDEIDFEFLGNSSRQPYIVHTNVYTQGKGGREQRFSLWFDPTTSFHTYSIAWQTQGLDAKGRNRIRWVQQKFMIYNYCSDAARFPQGFPTECRGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXI7</accession>
    <name>A0A068UXI7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00035830001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXI7"/>
    <dbReference type="FunCoup" id="A0A068UXI7">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXI7"/>
    <dbReference type="Gramene" id="CDP12348">
        <property type="protein sequence ID" value="CDP12348"/>
        <property type="gene ID" value="GSCOC_T00035830001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXI7"/>
    <dbReference type="OMA" id="IFKGYGK"/>
    <dbReference type="OrthoDB" id="1670832at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXI7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000010">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051955">
        <property type="entry name" value="PME_Inhibitor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080:SF303">
        <property type="entry name" value="PECTINESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31080">
        <property type="entry name" value="PECTINESTERASE INHIBITOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="8">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="245" mass="26763" checksum="32C9969DABD175A0" modified="2014-10-01" version="1">MDSINFFKGYGKVNNPAGNQQPASNRRRRILLAASLAVFLTIVLGAMIGALIYESATEPPESEEEQLPASDSGESLKTVCAVTQYLDSCINSISALNDPPKSDPVHFFNLSLQVSQRELASLASLPKTLISKSNDRRAESALKDCVNLFDDSLSQLNRSAELMKVAVVGPAEKLLTEMRISDMQTWISAAMTDQDTCLDGLDEMGSTVVDELRTRVHKSSEYMSNSLAILNNLKSLVDKFGLKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY46</accession>
    <name>A0A068UY46_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038245001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY46"/>
    <dbReference type="FunCoup" id="A0A068UY46">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UY46"/>
    <dbReference type="Gramene" id="CDP13341">
        <property type="protein sequence ID" value="CDP13341"/>
        <property type="gene ID" value="GSCOC_T00038245001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY46"/>
    <dbReference type="OMA" id="GPFSRCP"/>
    <dbReference type="OrthoDB" id="525163at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY46"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34687">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34687:SF1">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655224" evidence="2">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="101" mass="10188" checksum="209EEC88DEDE4956" modified="2014-10-01" version="1">MGPIVLTQLATGLSVLAGAVVVKSVMDSKTMFGPGQFPRCPTCNGTGRVACLCSRWSDGDIGCRTCAGSGRRSCTSCGGSGTGRPIPVQLSAGPPRNQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZS6</accession>
    <name>A0A068UZS6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 and DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00038867001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 2 heme b groups non-covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZS6"/>
    <dbReference type="STRING" id="49390.A0A068UZS6"/>
    <dbReference type="Gramene" id="CDP13807">
        <property type="protein sequence ID" value="CDP13807"/>
        <property type="gene ID" value="GSCOC_T00038867001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZS6"/>
    <dbReference type="OMA" id="DYRKYWN"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZS6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045265">
        <property type="entry name" value="AIR12_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017214">
        <property type="entry name" value="UCP037471"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF175">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04526">
        <property type="entry name" value="DUF568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037471">
        <property type="entry name" value="UCP037471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655414" description="Cytochrome b561 and DOMON domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="13">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="14">
        <location>
            <begin position="176"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037471-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="409" mass="46167" checksum="9658DC0503072842" modified="2014-10-01" version="1">MSPDNRFRVAFVLSLLLPVFADVQDCSEEFREEAAKKINITSCRKQSLGAEFAWNYNNGTRRLEILFGAKLHGGMGWLAWGLNPGKHAGMVGTQALIGIKLSNGTSSHDTYSITGSTKLGCKLLPSKIDLEVGDFSFSFPEADFAVIQATIVLPREYNDSSTNVVWQVGNFADGKQPFMHPKNIWHLSSKETINLISGSVRGDGAHKLQKLRKVHGILNIVGWGTFLPVGAIIARYFRKFPVEWSQWFRLHVSCQILGYLLGTSGWIIGLWLGNASKYYGYHTHRVLGIVIFTFTTLQMFALRLKPKRNDDYRVYWNMYHHFLGYSLLAIISVNIFHGISILNVDHTWKWAYIGLLCLLGSIAVVLEIYTWIKFWKRESPGIHKTQDQDQKDLHRGNKNDSGASTASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V050</accession>
    <name>A0A068V050_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00038092001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V050"/>
    <dbReference type="FunCoup" id="A0A068V050">
        <property type="interactions" value="1416"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V050"/>
    <dbReference type="Gramene" id="CDP13223">
        <property type="protein sequence ID" value="CDP13223"/>
        <property type="gene ID" value="GSCOC_T00038092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V050"/>
    <dbReference type="OMA" id="MQAFCIA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V050"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP13223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="422" mass="43699" checksum="888731016482571E" modified="2014-10-01" version="1">MAWNIGANDVANAMGTSVGSGALSLMQAVLIAAVLEFSGALLMGTHVTSTMQKGILVANVFDGKATLLFAGLLSSLAAAGTWLQVASYYGWPVSTTHCIVGSMVGFGLVYGGTGAVFWSSLARVTSSWVISPLMGAMVSFVVYKCIRRFVYSAPNPGQAAAAAAPIAVFVGVTGISFAAFPLSKQFPLAVLQALACGTAGAFIVYRIIQKQLGHLLVKSNSGEGEPKEEIIHTKNVGFLSDFAGPKGTQLQLVYGVFGYMQVLSACFMSFAHGGNDVSNAIGPLAAALSILQGGVSGAEIVIPNHILAWGGFGIVAGLTMWGYRVIATIGKKITELTPTRGFAAEFAAASVVLFASKLGLPISATHTLVGAVMGVGFARGLNSVRAETVREIVTSWAVTIPAGAIFAVIYTWILTKLFACIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2Y1</accession>
    <name>A0A068V2Y1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042334001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739176">
        <property type="protein sequence ID" value="CDP14864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2Y1"/>
    <dbReference type="FunCoup" id="A0A068V2Y1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP14864">
        <property type="protein sequence ID" value="CDP14864"/>
        <property type="gene ID" value="GSCOC_T00042334001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2Y1"/>
    <dbReference type="OMA" id="DIFWPSA"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2Y1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF1">
        <property type="entry name" value="HPP FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="254" mass="27057" checksum="BC99834C681BAB6D" modified="2014-10-01" version="1">MGLQNYLPKPPAPVSSSAPPLNSQLIVHFCSNIYSCKSNEKQTKLCNLVTSLGLHSHDGKRFTSVRRKGELRIVASSSSSSSNVPAPFWDSWAPQKGSQAPSLSDIFWPSAGAFAAMAILGKIDQILAPKGISMTIAPLGAVCAVLFATPSAPGARKYNLFMAQIGCAAIGVIAFTVFGPGWLARSSGLAAAIAFMICTRAVHPPAAGLPLLFIDAPKLHRLNFWYALFPGAAACILLCLIQEMVCYLKDNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V313</accession>
    <name>A0A068V313_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Subtilisin-like protease fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042587001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V313"/>
    <dbReference type="STRING" id="49390.A0A068V313"/>
    <dbReference type="Gramene" id="CDP15046">
        <property type="protein sequence ID" value="CDP15046"/>
        <property type="gene ID" value="GSCOC_T00042587001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V313"/>
    <dbReference type="OMA" id="YRAGHIN"/>
    <dbReference type="PhylomeDB" id="A0A068V313"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="3">
        <location>
            <begin position="351"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="475" mass="51697" checksum="179740818A459456" modified="2014-10-01" version="1">MNHGILTSASAGNWGNGTTGLLNNYSPWALTFAAATIDRKFVTKVHLGDKEVYVGVSINAFDLNGTLYPLVYSVDGLAIGHDGNESRYYMIGSLNDTNQVTGKIVFTDHLNSWMRATDVGAIGIVMHAKGPLDYGDTYSLPASLLYNRDGNQILSCINSTSDPTTTIDKSIEIIDKAASSIVSFSSRGPNPITVDILKPDLSAPGVEILAAWSEATTVMGYVGDKRSSSYVKSFNPTWSPSAIKSALMTTDFLKSFHQSYFLILNMIKKHKDISSYSKIISAEKDIDAEFAYGSGQINPLKAVTPSLVYDIEEKDFVSFLCRQTYNITSLRLITGDSIISCSKDNNSSVWDLNYPSFTLSAPSGHVARVFHRTVTNVANVGSTYKATIIAPPQLSVQVNSTILTFESTGQKQSFTMKVKAHIAKNITSGSLVRDDGVHQVRSPVVAHSFESRRKDDYTGSFLKGGFSYKGFHPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3Q3</accession>
    <name>A0A068V3Q3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00043160001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3Q3"/>
    <dbReference type="Gramene" id="CDP15430">
        <property type="protein sequence ID" value="CDP15430"/>
        <property type="gene ID" value="GSCOC_T00043160001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3Q3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="9467" checksum="6962F3729BDE2C4A" modified="2014-10-01" version="1">MMLVSQYLIISKKKKGLGTRLYTRRARTRGFKTHRNSSTRHPHIYMLVKLAKWCAGWMPKPRPPQIQLHVLNFMPTPNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V509</accession>
    <name>A0A068V509_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NUCLEAR FUSION DEFECTIVE 6, chloroplastic/mitochondrial-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016762001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V509"/>
    <dbReference type="FunCoup" id="A0A068V509">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V509"/>
    <dbReference type="Gramene" id="CDP15865">
        <property type="protein sequence ID" value="CDP15865"/>
        <property type="gene ID" value="GSCOC_T00016762001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V509"/>
    <dbReference type="OMA" id="FRIGAKT"/>
    <dbReference type="OrthoDB" id="736963at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V509"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043459">
        <property type="entry name" value="NFD6/NOXY2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156">
        <property type="entry name" value="OS02G0230000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156:SF48">
        <property type="entry name" value="PROTEIN NUCLEAR FUSION DEFECTIVE 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9936" checksum="F4B96D0B881FC9FE" modified="2014-10-01" version="1">MAISAASAAARSIFRSSSVRNAAARVTSKAKPSRSPFSSPSRTPLSHRVFRSPVEMSACVESIQPYHTATASALMTSLLTVSRCSYAWLPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5B2</accession>
    <name>A0A068V5B2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00042640001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5B2"/>
    <dbReference type="STRING" id="49390.A0A068V5B2"/>
    <dbReference type="Gramene" id="CDP15078">
        <property type="protein sequence ID" value="CDP15078"/>
        <property type="gene ID" value="GSCOC_T00042640001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5B2"/>
    <dbReference type="OMA" id="IDEEYLW"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5B2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF29">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="240"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="485" mass="52898" checksum="6FBFBFAE1ED2B5CA" modified="2014-10-01" version="1">MALSVEKTSSGREYKVKDLSQADFGRLEIELAEVEMPGLMACRAEFGPSQPLKGARITGSLHMTIQTAVLIETLTALGASVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGSEGGPDLIVDDGGDATLLIHEGVKAEEEYEKTGKLPDPSSTENAEFQIVLGIIRDGLKVDPKKYHKMKGRLVGVSEETTTGVKRLYQMQANGTLLFSAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKVAVVCGYGDVGKGCAAALKSAGARVIVTEIDPICALQALMEGIPVLTLEDVVSKADIFVTTTGNKDIIIVDHMKKMKNNAIVCNIGHFDNEIDMLGLENYPGVKRVTIKPQTDRWIFPENETGIIILAEGRLTNLGCATGHPSFVMSCSFTNQVIAQLELWKEKATGKYEKKVYVLPKHLDEKVAALHLGKLGAKLTKLTSGQAAYINVPVEGPYKPPHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6I6</accession>
    <name>A0A068V6I6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00017337001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739203">
        <property type="protein sequence ID" value="CDP16221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6I6"/>
    <dbReference type="STRING" id="49390.A0A068V6I6"/>
    <dbReference type="Gramene" id="CDP16221">
        <property type="protein sequence ID" value="CDP16221"/>
        <property type="gene ID" value="GSCOC_T00017337001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6I6"/>
    <dbReference type="OMA" id="HCVLREC"/>
    <dbReference type="OrthoDB" id="1704635at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6I6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP16221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="139" mass="14916" checksum="740E3CFBF5D55DFA" modified="2014-10-01" version="1">MASSLSGICFNPLKTHLPKPLPHSKNSVFPSKTSPQLVNINAYHQPGVEAGKKAAGEVLALQKRVLAVLNEASCKEPVEPLTLEEVADRCHASEDIEMIFKIIAHMAANDRAIIAEGSCGSPRSIKVVLGECNVDELYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6S6</accession>
    <name>A0A068V6S6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00018485001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739212">
        <property type="protein sequence ID" value="CDP16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6S6"/>
    <dbReference type="FunCoup" id="A0A068V6S6">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6S6"/>
    <dbReference type="Gramene" id="CDP16505">
        <property type="protein sequence ID" value="CDP16505"/>
        <property type="gene ID" value="GSCOC_T00018485001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6S6"/>
    <dbReference type="OMA" id="GSICQAC"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6S6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000468">
        <property type="entry name" value="PTI1-like tyrosine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655585" description="Protein kinase domain-containing protein" evidence="15">
        <location>
            <begin position="25"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="458"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP16505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="767" mass="84134" checksum="B5CB41FDAB1A94CD" modified="2014-10-01" version="1">MAIFHQKFFTLVLCFLSSLPFICPLSTVSISQAGNQTLVCALIPSSKQQSHLNCTSFPEGIPIRVGPSLTSFSAIVGGNGFLCALRSSSSSTSIVFCWRFSSNVTNMAHKRIYVGPILEELDAGNSHICGLVSRTKRLECWQWKEFNSTRNSLITSSVAVAENFVCGLLKSGKIQCLGSFANVTDHVPAGIFTVVAAGFRHACAISLTGTLECWGGMAGVKPSGQFKSLALAENRSCALRRPNGTVACWGENNFDLPIYLQQTSFISLEAKGNVFCGVATSNYSLFCWGNDEILDSKATVFNSVIPGPCRKQCPCELLPNYGSYCSQGQVICQPCSIFLSSDKNPPSSPSPLLPVPRMNTKSSSQWNKKLVAFLVVGCIGSLSFLIVLCFLFYKHCKNKASRVHDSGPMDDPARAPQSSQQQAPPGLEKKLSHLISMGNGNRLEEFSLEVLLRATNNFSEKHKIGTGSFGSVYMGTLDDGLEVAIKRAEISSCSSYHHAGGTKRSQEDKDYAFLHELEFLSRLNHRNLVRLLGYSEDCNERVLVYEYLDNGTLFDHIHKLENSPLMSWAARIKVALDAARGIQYLHEYAVPPIIHRDIKSSNILLDATWTAKVSDFGLSLMGPPDDVSYLSMSAAGTVGYMDPEYYRLQQLTTKSDVYSFGVVLLELLSGCKAIHKNKNDEPRNVVDFVVPYIVQDEIHRVLDQRMPPPTPFEIEAVAYVGYLAADCVRLEGRDRPTMTEIVNSLERALAACLATPRLSRSSTGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8T0</accession>
    <name>A0A068V8T0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00004778001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739225">
        <property type="protein sequence ID" value="CDP16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8T0"/>
    <dbReference type="Gramene" id="CDP16962">
        <property type="protein sequence ID" value="CDP16962"/>
        <property type="gene ID" value="GSCOC_T00004778001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8T0"/>
    <dbReference type="OMA" id="ENENQGM"/>
    <dbReference type="OrthoDB" id="1910803at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8T0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="286" mass="31780" checksum="A8A86E2255C89D85" modified="2014-10-01" version="1">MANSHQTQLLLRNPSPSQSPSHDHPTINTERMLANALGASESGDAVTIIYFHHSLSYKYRGTLRVQNILSSVHHVMSLLPEHLPLRLLRTSHELRIFLDSTDNTLLLLDFCGWTPGLLARGLSEETNGTLVQEEKQPKVDGIQSPKMSCSADKGLNQFPWLTELTLGNDGNLSEADKIAHTDGFSCTVDEFQLLKSFLPKLMKFARDFFLPPERLGFGLVSEKSLLSELDIEASAAPWLMKLYSAGCPTCSKVLTEGDDLKAILQTQESVVTEASWHSIFLFTSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8Z6</accession>
    <name>A0A068V8Z6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="6 16">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00004942001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 16">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Plastid</location>
            <location evidence="2 16">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="6 16"/>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8Z6"/>
    <dbReference type="FunCoup" id="A0A068V8Z6">
        <property type="interactions" value="2247"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8Z6"/>
    <dbReference type="Gramene" id="CDP17037">
        <property type="protein sequence ID" value="CDP17037"/>
        <property type="gene ID" value="GSCOC_T00004942001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8Z6"/>
    <dbReference type="OMA" id="WFDQWFG"/>
    <dbReference type="OrthoDB" id="419752at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8Z6"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3110.10:FF:000002">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0934">Plastid</keyword>
    <keyword evidence="14 16" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="19">
        <location>
            <begin position="194"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="659" mass="71574" checksum="029DE46888ECB84A" modified="2014-10-01" version="1">MSTLRSNKNWQINTIQTSPSQTQTQTFILFFSSIYRAVTPKLGKINTQTGAAKRIREIAETDGVYSFREGQVEDLLSGRSVLSSLYLFLLFFFVFLNLFERGNLIPILGLGFRVLGFEIDIEMAITITSLGYYCCHCHHTINTSPPKLASSRRHTLSWRSFRCSYSTTVTPYSNAPIDGSSTSRLDCVIVGAGITGLTIAQALSGNNVLVTEARERVGGNITTVERDGYLWEEGPNSFQPSDPMLTLVVDSGLKDDLVLGDPKAPRFVFWEGKLRAVPSSPTDLPFFDLMSFPAKLRAAFGALGFRPSPPANEESVEQFVRRNLGNEVFERLIEPFCSGVYAGDPSKLSMKAAFGKVWKLEQNGGSIIGGTIKALKDRSSSAKVPRDPRLPKPKGQTVGSFKKGLAMLPDAISSRLGSKVKLSWKLSSIAKSEDGGYTLIYETPAGVISVQTRSVVMTVPSYVASSLLRPLSAAAADALSKFYYPPVAAVTISYPQEAVRGNCLIDGELKGFGQLHPRTQGVETLGTIYSSSLFPNRAPPGRVLLLNYIGGATNPGISLKTESQLVEAVDRDLRKMLINSNAREPLVLGVRLWSQAIPQFLVGHLDTLNAAKNGLANCGLKGLFLGGNYVSGVALGRCVEGAYEVAAEVKDFLAQYVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAZ9</accession>
    <name>A0A068VAZ9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00004322001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDP17916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAZ9"/>
    <dbReference type="STRING" id="49390.A0A068VAZ9"/>
    <dbReference type="Gramene" id="CDP17916">
        <property type="protein sequence ID" value="CDP17916"/>
        <property type="gene ID" value="GSCOC_T00004322001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAZ9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAZ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF26">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13681" checksum="A41C01C3D06A46FC" modified="2014-10-01" version="1">MEIICNQRQRRIQFNSPAQTTGAAATVLLHKQASKQAAEREERMIIIGNQMDYTDQIIKEIILVMLTAGTNTSSVTIEWALSLLLNHPESFDWKRISEKEIDLAERTRVSMPKAKPLEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB20</accession>
    <name>A0A068VB20_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00003888001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB20"/>
    <dbReference type="FunCoup" id="A0A068VB20">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB20"/>
    <dbReference type="Gramene" id="CDP17772">
        <property type="protein sequence ID" value="CDP17772"/>
        <property type="gene ID" value="GSCOC_T00003888001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB20"/>
    <dbReference type="OMA" id="LGVDDGM"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB20"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF48">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="561"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="649" mass="71418" checksum="A39A9F21DE3FA5D9" modified="2014-10-01" version="1">MAFWGIEVKPGKPVTHSFDKVRRRLRISQATLGIGSAITKSLVQCNVGNKSPVFLCALLPDKTESCHLDLEFEEADDVVFSVIGPRSVYLTGYYVSNDQHPALNSDTESYGEDIANTETEESGLRSDEDEYEDSFIDDSDPVLSPPSPDGVVKEMDDVKEMRERKGSKRLQGKKFVIIDSDDETTSQESEDDDNHLISASKNNMVAKDKVTVETIAEPADCGASGHVSKEKADPVTMPKEPKRKTLPCNASFPADEVKLDKEMEPKEIRCLSQEAETFEDNSVNPIDSPVHQVHANLAKVDDASGSLHASKKEDKRQAISFSSRAVSDFHSVYVNTTSELAPVNNKKSKRKRKEQADGDKIIEGSNSNHKMSLKEDKVMQAVAETDNKEQDLPMPNESNQEPTINGKIDLDGPSSLPHPEKDQPSKKRRKKGSIKERSDGSNDATSKKILVDDQLKENLLKDEKIVSDLPATTSEDKKQTADEGTNFDFAAEGNQLEKPKKKKKKAKTVDNKENMNVSGSLLSENESREPSKSCQVRTLSNGLVIEQLALGKQEGKIAAIGKKVKVYYTGMLKESGHVFDSNVGNSPYKFRLGDEAIIGGWNIGLEGMHVGDKRRLIIPPALGYGSKGAGENVPPNSWLVYDVELAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD90</accession>
    <name>A0A068VD90_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012211001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739255">
        <property type="protein sequence ID" value="CDP17648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD90"/>
    <dbReference type="Gramene" id="CDP17648">
        <property type="protein sequence ID" value="CDP17648"/>
        <property type="gene ID" value="GSCOC_T00012211001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD90"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="62" mass="7358" checksum="75440EA45E5E9054" modified="2014-10-01" version="1">MPKVGKDTCYLFKQVLHLTAMAMRLVKSWSGRFLVLAFQMFQKLQFRHLPETVVRTTVWTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDG6</accession>
    <name>A0A068VDG6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00000322001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="HG739341">
        <property type="protein sequence ID" value="CDP18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDG6"/>
    <dbReference type="FunCoup" id="A0A068VDG6">
        <property type="interactions" value="2937"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDG6"/>
    <dbReference type="Gramene" id="CDP18609">
        <property type="protein sequence ID" value="CDP18609"/>
        <property type="gene ID" value="GSCOC_T00000322001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDG6"/>
    <dbReference type="OMA" id="FKLSTMV"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDG6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18015">
        <property type="entry name" value="DEXHc_RecQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000510">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001215">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001544">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="101"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="301"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="599"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="708" mass="79681" checksum="1A2809156BD314CF" modified="2014-10-01" version="1">MGSSEEILQELLNVEVELHDVQEQLKELLDRQDELYQRQSELKALLESCESSSRRSPGKIDGSSDCTENWSGTFEWDSQADDIRFNVFGIPTYRANQREIINAVMTGRDVLVIMAAGGGKSLCYQLPAVLKNGVALVVSPLLSLIQDQVMGLAALGIPAFMLTSTTGKEDEKFIYKALEKGDGELKILYVTPEKISKSKRFMSKLEKCHHAGRLSLISIDEAHCCSQWGHDFRPDYKNLGILKTQFPDVPVIALTATATKKVQEDLMEMLHVSKCVKFVSTVNRPNLFYTVREKSSVGKVVIDEIAAYIQASYPNNESGIVYCFSRKECEQVAKELREKGISADYYHADMDVHAREKVHLRWSNGKLQVIVGTVAFGMGINKPDVRFVIHHSLSKSMETYYQESGRAGRDGLPSECVLYFRPGDVPRQSSMVFYENAGLQNLYDIVRYCLSKRECRRGAFFRHFAEPLRDCNGMCDNCAFASDVKELDVSAHAKMIVSLLQDLQENDQRVTMLQLADKLKVKQKGVDPELKRDELEQLVIQLILERVLKEEFQHTAYATNAYVTIGPLSKYVLHGKKIIKLEVSSGQKGNSSILKQSKRTKSGDLEFKLDKLRKELASINGGIFPHSVLSTQQISMLSVQQPKSVEQLEKVIGKLKTQKYGVRILEEIENFESNNQSNNILESQISRASKKMKSTKTPVIIESSGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDK2</accession>
    <name>A0A068VDK2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00003852001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May interact with bacterial adhesins thereby protecting the reproductive tissues from microbial attack. Has no oxalate oxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. In the absence of manganese, it forms tetrameric and pentameric forms which show superoxide dismutase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Secreted</location>
            <location evidence="1 15">Extracellular space</location>
            <location evidence="1 15">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDK2"/>
    <dbReference type="FunCoup" id="A0A068VDK2">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP17748">
        <property type="protein sequence ID" value="CDP17748"/>
        <property type="gene ID" value="GSCOC_T00003852001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDK2"/>
    <dbReference type="OMA" id="FQKNNAN"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010497">
        <property type="term" value="P:plasmodesmata-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000025">
        <property type="entry name" value="germin-like protein subfamily 2 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012542644" description="Germin-like protein" evidence="16">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="17">
        <location>
            <begin position="52"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP17748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="210" mass="22367" checksum="E29DCAAE869F4E40" modified="2014-10-01" version="1">MLMVFLTISFNQVFASDPDMLQDVCVADLTGKPKVNGFICKENITANDFFTTILGTPGATNNTFGSVVTGANVEKVPGLNTLGVSLSRIDYAPGGLNPPHTHPRATEMVFVLEGELDVGFITTANVLISKSIKKGEVFVFPRGLVHFQKNNGNVAAAVISAFNSQLPGTQGISVTLFASNPPVPENVLTMAFQIGSKEVDKIKSRLAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFM4</accession>
    <name>A0A068VFM4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_535</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00011274001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739619">
        <property type="protein sequence ID" value="CDP19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFM4"/>
    <dbReference type="Gramene" id="CDP19521">
        <property type="protein sequence ID" value="CDP19521"/>
        <property type="gene ID" value="GSCOC_T00011274001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFM4"/>
    <dbReference type="OMA" id="HESTREC"/>
    <dbReference type="OrthoDB" id="3794806at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF203">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="164"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="8">
        <location>
            <begin position="436"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="560" mass="64160" checksum="F81C2E7E3870AE45" modified="2014-10-01" version="1">MAMQDIGVSIVGKIAEKFIDPIMRQFQYLFCYRSNIETLRNGIKKLELTKTEVQRSVDEARNNGEEIKPIVTDWLRQANGLEKEADTIFEGMENVKVNCFKIVRLPNLKSRYLIGRHAAKRGNDAEKHLRERWFDEVGYLPPLGKMPFSESTPSFEESLITRMSMKREVIEALKQDKRSLLAICGMAGVGKTFLLEQIADQVKSEKLFDGVAFATVSQNPDIRNVQNQLAEQLRMTLISEHSGRARAEQIYTRLTNSDERNLVMLDDIWEEVDLRSLGIPIRLGECKGLKVVLTSRFSHVCRNMEAEIFEVNALPKEEAWHLFKKVVGISDDSALSDVVKQVAEECKGLPLAIVVVARAFRTNYTTPESWKLALGQLKKYTMRDLERVQDFVFSRIEWSYDRLKSVEAKLLLLFCSLFPEDYSIPVECLVRYGKGLEIQLQEMKLQRINFIEYLWKGPIEPPSLCNLRVIEVSNCQRITTLFSQSVLKCLVNLQKIVVHSCKNLESIVMREENMKDQVLELLQLKVVTLQYTGLEGFGCEGDTYSKAFLNQVSLSLCISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VID4</accession>
    <name>A0A068VID4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CCT-eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00012535001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739567">
        <property type="protein sequence ID" value="CDP19433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VID4"/>
    <dbReference type="STRING" id="49390.A0A068VID4"/>
    <dbReference type="Gramene" id="CDP19433">
        <property type="protein sequence ID" value="CDP19433"/>
        <property type="gene ID" value="GSCOC_T00012535001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VID4"/>
    <dbReference type="PhylomeDB" id="A0A068VID4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP19433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="24031" checksum="A1256141679AB4BC" modified="2014-10-01" version="1">MQIFMKTLIRKTITLEVESSDTIDNVKAKIQDKEGNPPDQQCLIFTDSSASSWILFSYASFEQQPKKFVNPKILLLNIELELKSEKENAEIRLSDPSQYQSIVDAEWNIIYDKLDKCVKSGAKIILSRLAIGDLATQYFADRDLFGAGRVTEEDLHRVAAATGGTIQTTVNNEVQFYCSVLDIIYALHLFSELVKYAIFIALFLFKKFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIG7</accession>
    <name>A0A068VIG7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_507</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00013628001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739591">
        <property type="protein sequence ID" value="CDP19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIG7"/>
    <dbReference type="Gramene" id="CDP19468">
        <property type="protein sequence ID" value="CDP19468"/>
        <property type="gene ID" value="GSCOC_T00013628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIG7"/>
    <dbReference type="PhylomeDB" id="A0A068VIG7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="90"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="429"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="515" mass="58402" checksum="66D156D37D431E4B" modified="2014-10-01" version="1" fragment="single">MADAVISATIRVALETAASLATDRIGMLCGFKKDVASMTRTLSFINALLADAEERQQNQDRGVQEWLKSLEEVAYDAGNVLDELNYESLRLPITGMGGLGKTTLAKSIYNNHQIDGHFQKKIWVCVSKKVPIVELFKLILVHLTGEKVEVDVRDVIVGKIRNHLEGKRYFLVLDDVWDDDQALWDDFFTTLKGLHPTNGSWCLVTTRLRMMENEAYPLGKLPDDLCWSILKEKVVGGEEEPDELKAIKERVIKRCDGLPLAASVIGGLLSLKRKEEWQPILENRLLSLSAGGDHVMQILKLSFDNLPSPYIKKCFAYCSIFPKDSEIERNMLIELWMAEGFLQADLNSQMIMEEIGMNYLRILLQSSLLEETRNYQGTCYKMHDLVHDLAESMSKSTKVIIDRDTSILDNGNQIRYLATVSFAVDLSGDMLMKLKNLYVLNLSPTRTRELPVSIGKLIHLRYVNLERSSISILPDSLCKLYNLQTLTLSESSVKHLPKGMCNLISLRHLHYYIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VII5</accession>
    <name>A0A068VII5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_1161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00008100001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740245">
        <property type="protein sequence ID" value="CDP20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VII5"/>
    <dbReference type="FunCoup" id="A0A068VII5">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VII5"/>
    <dbReference type="Gramene" id="CDP20389">
        <property type="protein sequence ID" value="CDP20389"/>
        <property type="gene ID" value="GSCOC_T00008100001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VII5"/>
    <dbReference type="OMA" id="GPMMQAF"/>
    <dbReference type="OrthoDB" id="416832at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VII5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003742">
        <property type="entry name" value="PRK05339.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756:SF3">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="286" mass="31521" checksum="16E29C9639D6253C" modified="2014-10-01" version="1">MVSDGTGWTAEHSVNAALGQFEHCLVDRVCPVSTHLFSGIDDVERLMEVIKQAAKEGAMLVYTLADPSMAESAKQACQLWGIPSADILGPITESIASHLGVSPSGLPRWARGRSSSLSEDYFRRIEAVEFTIKQDDGALPENLHKADIVLAGVSRTGKTPLSIYLSQKGYKVANVPIVMNVKLPSALFEIDPEKVFGLTINAVVLHTIRSARSRTLGFAEDIRSNYSEMDHVKEELEFAAKIFAQNPVWPVIEVTGKAIEETAAIVLRLFHDRKNRCSMPRISKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ01</accession>
    <name>A0A068VJ01_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00010859001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739670">
        <property type="protein sequence ID" value="CDP19648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ01"/>
    <dbReference type="STRING" id="49390.A0A068VJ01"/>
    <dbReference type="Gramene" id="CDP19648">
        <property type="protein sequence ID" value="CDP19648"/>
        <property type="gene ID" value="GSCOC_T00010859001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ01"/>
    <dbReference type="OMA" id="YCNIEHR"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ01"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="284" mass="30489" checksum="CD82E08CC9D6EA84" modified="2014-10-01" version="1">MDDLNKISTIGNRSDLPSSFQPQDILQQLTSLPSLFNTLQARRAIIPAANGHCSARALARYYAALVDGGVVPAPHSSSGPPLGSHLHTPKFPTKNICKKNRAANIKNLLTASKKIGNFHQRQEHDSSGGGNSRRTARGNSYTRVPIDSSSSKPCASEGDSFDGRNVSKLFCSPRIHDAFMGVGEYENLALPDGQFGLGFKRSYTMSGDIVGFGHSGMGGSTGYCNIEHRFAIAVTINKMSMGTVTAKVIDLVCTELNIPLPKELRRFVEGSPDDVLNSGTPIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ07</accession>
    <name>A0A068VJ07_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00000097001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740463">
        <property type="protein sequence ID" value="CDP20574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ07"/>
    <dbReference type="FunCoup" id="A0A068VJ07">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJ07"/>
    <dbReference type="Gramene" id="CDP20574">
        <property type="protein sequence ID" value="CDP20574"/>
        <property type="gene ID" value="GSCOC_T00000097001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ07"/>
    <dbReference type="OMA" id="YAHEFET"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ07"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19124">
        <property type="entry name" value="AKR_AKR4A_4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000014">
        <property type="entry name" value="NAD(P)-linked oxidoreductase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044497">
        <property type="entry name" value="AKR4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="305" mass="34080" checksum="597F166DB641A5D8" modified="2014-10-01" version="1">MPLVGFGCAAQPLPPSEQLVSTFIDAMEIGYRHFDTAACYGTEEALGKAVAKALEIGLIKSRDELFITSKLWCTDADHDLVLPALKQTLGKLGLEYLDLYLIHWPLRLKQGTEMLNFTKDAILPFDMHGTWKAMEECSKLGLTKSIGLSNFTCEKISKLQESATILPAVNQVEMNVGWQQRKLVPFAKEKGIHISAWSPLGGYGTSWGSNAVMESPIIKNIADSRNKTVAQVALRWVYLQGASVIVKSFSKERMKQNLQVFDWELTKEEMDQILQIPQRRAPGTEALVDPTGPYKSLEEFWDGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ78</accession>
    <name>A0A068VJ78_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_1675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00005981001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740759">
        <property type="protein sequence ID" value="CDP20746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ78"/>
    <dbReference type="STRING" id="49390.A0A068VJ78"/>
    <dbReference type="Gramene" id="CDP20746">
        <property type="protein sequence ID" value="CDP20746"/>
        <property type="gene ID" value="GSCOC_T00005981001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ78"/>
    <dbReference type="OMA" id="IPGIMEK"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="20579" checksum="2511414570A01778" modified="2014-10-01" version="1">MLNMKEIPFIFLLLSSKQMIPGIMEKRVLILLYKALLVNRFKISMTRSVRNFEFMAPKKGLYRFCFTNRSPYHETVDFDVHVGHFPYYEQHAKDEHFNPLLEQISKLEEALYNIQFEQHWLEAQTDRQALVNENMSKKAVHKALLESIALIGTSVLQVYLLQRLFERKLGTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK91</accession>
    <name>A0A068VK91_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00006529001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741810">
        <property type="protein sequence ID" value="CDP21185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK91"/>
    <dbReference type="STRING" id="49390.A0A068VK91"/>
    <dbReference type="Gramene" id="CDP21185">
        <property type="protein sequence ID" value="CDP21185"/>
        <property type="gene ID" value="GSCOC_T00006529001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK91"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK91"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="113" mass="12854" checksum="3EC0093917AB0359" modified="2014-10-01" version="1">MLKYLVFLPIDGQAEFKVSRSSKNFFCLCHYCLLHCYHFQDGDAVLRFSKPNKCWVESSQKRYVPCAGDTVLGIVVDSRSDNFLVDIKGPTLAFLPVLAFEGGTRRNIPKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKI3</accession>
    <name>A0A068VKI3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_2729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00007702001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741813">
        <property type="protein sequence ID" value="CDP21186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKI3"/>
    <dbReference type="STRING" id="49390.A0A068VKI3"/>
    <dbReference type="Gramene" id="CDP21186">
        <property type="protein sequence ID" value="CDP21186"/>
        <property type="gene ID" value="GSCOC_T00007702001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKI3"/>
    <dbReference type="OMA" id="MEYILPY"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKI3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF62">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 81, SUBFAMILY D, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP21186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="226" mass="26018" checksum="58D05D073E28D670" modified="2014-10-01" version="1" fragment="single">MEQNMLSNISILFLTLILPLLLLHKKRQKKSLPPSPPSLPMIGHLHLLKPPLHRTLKRLSDKYGPIFSLRFGNQLAVITSSPVIVEECLTKNGIVFANRPSGLATKYLNYDGTTMATAPYGPLWKRLRRISTMELFSGTRLNMFSANRQEETKLLVKNLYKKSSQNFARVEIRSQMMEMAINNIMTMFSGKRYYGYEVEDNKEALQFRDIVREMFELGNLSPVDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKW1</accession>
    <name>A0A068VKW1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_3499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00009925001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG742583">
        <property type="protein sequence ID" value="CDP21346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKW1"/>
    <dbReference type="Gramene" id="CDP21346">
        <property type="protein sequence ID" value="CDP21346"/>
        <property type="gene ID" value="GSCOC_T00009925001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKW1"/>
    <dbReference type="OMA" id="SCINEDK"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKW1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="454"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="829" mass="94147" checksum="393BD3D54BC9C4ED" modified="2014-10-01" version="1">MAESVVVFLIKQLSALLSQESTLLGGLRPDVQFIKDELGSMKAFLRQAEAKGDNDSQLQEWVKQVREVAYDTEDVLDDFAFRFARGDADGFFGRVGKIYNSIKNLKARHRISLEIKDIKARVVEISARHQRYQSLYGTQEIGPSSSHLANADCDIRDQALLIEEAKLVGIDQPKKELISQVLDDNSHLKVVSVVGMGGLGKTTLVKKTRITDVASASCLESHDFIYKMKPLSDEESWTLFCNRTFQSNGCPSNLEKVSRKILKKCEGLPLAIVAMGGVLALKDKDRIDEWEMILHGFSGEVDGSGKLERIRRILLLSYNDLPHHLKSCLLYLSIYPEDYRIKRIDIYNILDTWIALGFIEEKEGMTATDIAKRYLKELINRSLIQVKGTRHNGILKECGIHDFLREMIVSKSKEQSFTTVATGYCTRWPGKVRHLAIHNFTDNPPQGFNSLKSLRSLRTFKYEDPLTTSFLSKFLCGGPKLLKVLNLREAELDNIPKAVFKLFHLKYLNLSDTRVKIIPKSIGQLQNLEALILTGTTITELPVEILKLRRLRCLAVGRKGDYSNNYAIWGFKSPDGIGKLTSLESLAFIEANSGKIVMEIGKLIQLRQLWITKLRREDGKELVSSLLRLTNLQELYISSIKEEETLDLQHSISSRLGFLVRILLDGRLEGVPEWVMSLQSLSTLALYNSGLSEDENAIDCLGHLPNLVDLILHRAYEGETLCFKAGRFPKLQRLQLGQLKRLKWVRVEEESLSNLQQFLIVGCKLMEGLPLGLQNLTKLKFFGFYDMSDELIHKVQNLDKQSEDYQTISHIPQICTGHWINGEWKEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL19</accession>
    <name>A0A068VL19_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_3079</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00002207001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742163">
        <property type="protein sequence ID" value="CDP21279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="59"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP21279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="59" mass="6791" checksum="298385050741306F" modified="2014-10-01" version="1">MQIFVKTLTGKTITLEDNEGIPPDQQQFIFTDKQLEDGRTLANYNILKESTLHLICRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLM5</accession>
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        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_5202</fullName>
        </submittedName>
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        <name type="scientific">Coffea canephora</name>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">cv. DH200-94</strain>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLV1</accession>
    <name>A0A068VLV1_COFCA</name>
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        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_5180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013019001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF20">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="265" mass="29104" checksum="7F679FD9E0AAD6BC" modified="2014-10-01" version="1">MDDREVELSHPVLVPNSDSSSSVQASISVDSFLDELLRNAQTCTHTHTCNPPGPDAAHTHTCYHTHTQVIPSERVENPSEKVDGPCDSRKSTSKTRRSSGNREAVRKYREKKKAQTAYLEEEAKKLRLVNQQLIRKVQRQAILEAEISRLRSLLLDVRGKIDTELGAYPLQKQCISSFKVKEGDSGMQYSGLAMELQCENDLTCFHPQGDSSIEDGGFGGCDKMGASSWEGNCQSATVACKANGPAERNGMDSVETRLSSASQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VML7</accession>
    <name>A0A068VML7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable glutathione S-transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00001691001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. HSP26 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG746280">
        <property type="protein sequence ID" value="CDP21862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VML7"/>
    <dbReference type="STRING" id="49390.A0A068VML7"/>
    <dbReference type="Gramene" id="CDP21862">
        <property type="protein sequence ID" value="CDP21862"/>
        <property type="gene ID" value="GSCOC_T00001691001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VML7"/>
    <dbReference type="OMA" id="FWANSAT"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VML7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000012">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF762">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="224" mass="26076" checksum="3CCD92F68EE67140" modified="2014-10-01" version="1">MAEEVKLFRTWSSGYALRIVWALKLKGIEYETIFEDLTNKSPSLLQYNPIHGKVPVLVHDGKPVCESLVILEYVDETWKHNPLLPQDPYEKSMARFWANFGDDKLMKSIWQLFIAREKDQDVAAVEALENLKLVEEQLKGKKFFHGETVGYLDLAFGWFADFVSILEEIMSLKLVDGERFPHLSSWIQHFIDAPVIRDCWPPRDKMIIKFQVMRENYLAAATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQE1</accession>
    <name>A0A068VQE1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_8140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012899001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG747224">
        <property type="protein sequence ID" value="CDP21948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQE1"/>
    <dbReference type="STRING" id="49390.A0A068VQE1"/>
    <dbReference type="Gramene" id="CDP21948">
        <property type="protein sequence ID" value="CDP21948"/>
        <property type="gene ID" value="GSCOC_T00012899001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQE1"/>
    <dbReference type="OMA" id="RWRCAFT"/>
    <dbReference type="PhylomeDB" id="A0A068VQE1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="1">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="22095" checksum="770366A2474FAE9B" modified="2014-10-01" version="1" fragment="single">MSDASEASFNAVESPLLPTRAQKRCQVQKRWRVVSITVRSIRRFSSVKEEVVVNEGVELTPIVFDAQKRLRAFWTTLCSINAFCRAKDIAAENQSRLLDNPLPSPCDTVIDVMPERLSEPTPVKKIVTPECLSELARRKNSEQLHQLGGVPGVASYLKSNAESGIQGDDEEIARRRHNFGSNTIQKPTPKTLPIVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLN8</accession>
    <name>A0A068TLN8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00014483001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLN8"/>
    <dbReference type="FunCoup" id="A0A068TLN8">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLN8"/>
    <dbReference type="Gramene" id="CDO97215">
        <property type="protein sequence ID" value="CDO97215"/>
        <property type="gene ID" value="GSCOC_T00014483001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLN8"/>
    <dbReference type="OMA" id="WKLIAYA"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLN8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045016">
        <property type="entry name" value="NhaD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038006">
        <property type="entry name" value="NhaD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43269">
        <property type="entry name" value="SODIUM/PROTON ANTIPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43269:SF2">
        <property type="entry name" value="SODIUM_PROTON ANTIPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="13">
        <location>
            <begin position="160"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO97215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="582" mass="62431" checksum="ED6360AE7A93022D" modified="2014-10-01" version="1">MYTLLSIRSSHFSPSHNFNKNHDHHSHHHPLGFSTPLSLKSGQSYTIRPRDYGPKILHRSGVLVRAEDEARDLSSSSSTQQRQPQTHFEKQQLQELNSSSRECDPLCSVDETSSQDHPKTDFLKALAILAAAGTGTLAINHSWVAANQDLAMALLFGIGYVGIIFEESLAFNKSGLGLLLAVSLWVIRSIGAPSTDIAVSELSHASAEVSEIVFFLLGAMTIVEIVDAHRGFKLVTDNITTRKPKVLLWMIGLATFCLSSVLDNLTSTIVMVSLLRKLVPSSEYRKLLGAVVVIAANAGGAWTPIGDVTTTMLWIHGQISTLPTMKDLIVPSAVSLAVPLALMSLTSEVNGKGQNLPNVLSSEQTAPRGKLVFSVGIGALVSVPVFKAVTGLPPYMGMLLGLGVLWILTDAIHYGESERLKVPQALSRIDTQGVLFFLGILLSVSSLEAAGILRELANYLDANIPNVELIASAIGVVSAVIDNVPLVAATMGMYDLSSFPQDSKFWQLVAYCAGTGGSMLIIGSAAGVAFMGMEKVDFFWYLRKVSGFAFAGYAAGIAAYLAVHNLNFSLPTLAQFPLLSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMR4</accession>
    <name>A0A068TMR4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00014472001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMR4"/>
    <dbReference type="STRING" id="49390.A0A068TMR4"/>
    <dbReference type="Gramene" id="CDO97204">
        <property type="protein sequence ID" value="CDO97204"/>
        <property type="gene ID" value="GSCOC_T00014472001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMR4"/>
    <dbReference type="OMA" id="MEDHNSF"/>
    <dbReference type="OrthoDB" id="1896682at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006514">
        <property type="entry name" value="IRX15/GXM/AGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01627">
        <property type="entry name" value="A_thal_3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31444">
        <property type="entry name" value="OS11G0490100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21729">
        <property type="entry name" value="IRX15_IRX15L_GXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="325" mass="35595" checksum="E98F441DA890A7BA" modified="2014-10-01" version="1">MKSSSAKLILVHPSSLHKQGVAIAASHRLWLLLFLSFFALAFTLTLITTKDAMTAAAANAASASATVKAPLPRPVFDALLHYASVNYSAVGSRFSASELAAVAAVLRRCNSNAAPCNLLVFGLTHETLLWNSLNYKGRTVIVGDNDYFVTRLEQRHPEIEAYDVQFTTKVSELYELLEYSKEQLKNECRPVQNLLFSDCKLAINDLPNQIYDVAWDVILIDGPFGFLPTAPGRMSAIFTAGVLARSKKASAGKTDVFVHECNREVERVCSEEFLCRENLVETIDALGHFQVGETEANKRFQFCSDSGSIASSSSSPSSKKNRADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMS4</accession>
    <name>A0A068TMS4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015039001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMS4"/>
    <dbReference type="Gramene" id="CDO97640">
        <property type="protein sequence ID" value="CDO97640"/>
        <property type="gene ID" value="GSCOC_T00015039001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMS4"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045894">
        <property type="entry name" value="At5g08430-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46851">
        <property type="entry name" value="OS01G0884500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46851:SF15">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 19-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51402" checksum="2D251C13421A4974" modified="2014-10-01" version="1">MCLNLGGISTLFEHMERRNQLQTPSERLRLLEYHHAVIPEELEPVIEEIGHDQKGAEMSHESTFSINLNWKWGGNCTSRENKFHGPLSCQYEKQNLPEVSLSVSPNQSASKEKDNKMMASALEVSPEPSLACEDQCNMMLQTDAELCSSSVEVTKQNLPEENNKAFEVSPGLSLASEDQRNGMLQTDAELCILTVEVTKQNLPGENNKAFEVSPGLSLASEDQCNGMLQTDAELCISTVEVTKQNLPEVSLSISPNQSAPKEENNKALEVSPEPSLASEDQCNVVLQTDAELCSSPVEVAMQNLPRASLSISPRQPASKEKNNKTVASAHEVSPRPSHTCEDGQNAMLQVETDAELDGSAVEVTKQNQGMDAEGATSKKTVIVVSSDDESTWSYEPRKQHLEDPYSREWLILGPNGERNEEKYSLSLLKRWSDASSYALKYKAWKENGSEELAIPLADAIKKAFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN78</accession>
    <name>A0A068TN78_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Probable DNA helicase MCM9</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Minichromosome maintenance 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00014755001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Probable DNA helicase that may play a role in DNA repair during meiosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN78"/>
    <dbReference type="FunCoup" id="A0A068TN78">
        <property type="interactions" value="1707"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN78"/>
    <dbReference type="Gramene" id="CDO97414">
        <property type="protein sequence ID" value="CDO97414"/>
        <property type="gene ID" value="GSCOC_T00014755001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN78"/>
    <dbReference type="OMA" id="HYVKQHF"/>
    <dbReference type="OrthoDB" id="271325at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17760">
        <property type="entry name" value="MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002270">
        <property type="entry name" value="Probable DNA helicase MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058768">
        <property type="entry name" value="MCM9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26066">
        <property type="entry name" value="MCM9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="21">
        <location>
            <begin position="302"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDO97414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="660" mass="73463" checksum="A201FD1813504B63" modified="2014-10-01" version="1">MDNSYGKAKELASFLIKHYTEQLHSIILSPDPRLHYPLLVDFAELLDDNPTLAHLLFSHPAEYLLVFDEAAIWAQKVIFKDLKQWDNASVKDYVHVRINVSGSPLECPETFPSIGRVRVKHRGILLTLKGTVIRSGAIKMIEGEKIYECRNCKHRFKVYPEVETRNVIPKPTICPSQSSKFCESTRFNLIEDNKICHDYQEIKIQENAQVLGVGAIPRSIPVILKDDLVDTVKAGDDVIVTGVLTAKWSPDVKDVRCDLDPVLVANYVRRMNEVKSGIDIPDDVIMKFKQFWLDFENAPLKGRNAILRGICPQVFGLFTVKLAVALTLIGGVQHVDASGTKVRGESHLLLVGDPGTGKSQFLKFAAKLSNRSVITTGLGSTSAGLTVTAVKDGGEWMLEAGALVLADGGLCCIDEFDSMRGHDRATIHEAMEQQTISVAKAGLVTTLSTRTVVFGATNPKGQYDPDESLSVNTTLSGPLLSRFDIVLVLLDKKNPEWDAVVSSHILAEGEKENDNCNEDLTSTWPFPMLRRYIHFVKRNVRPVLSKEAENVISRYFQLQRRSATQNAARTTVRMLESLIRLAQAHARLMFRNEVTRLDAITAILCIESSMTTSAIVDSVGNALHSNFAENPDEEYAKQEMLILQKLCIIDEFPALKSNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ78</accession>
    <name>A0A068TQ78_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00014889001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ78"/>
    <dbReference type="STRING" id="49390.A0A068TQ78"/>
    <dbReference type="Gramene" id="CDO97518">
        <property type="protein sequence ID" value="CDO97518"/>
        <property type="gene ID" value="GSCOC_T00014889001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ78"/>
    <dbReference type="OMA" id="TRIEMSQ"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902065">
        <property type="term" value="P:response to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000359">
        <property type="entry name" value="Mitogen-activated protein kinase 1, putative, expressed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF29">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO97518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="294" mass="32678" checksum="47B0F4360B3C81FE" modified="2014-10-01" version="1">MAESVCCVSPSATYRRSINSWQKGEILGSGSFGTVFEGYTDDGLFFAVKEVSLLDQGSQGKQSIYQLEQEILLLSQFQHDNIVQYLGTEKDDSKLYIFLELVTKGSLLSLYQKYNLRDSQVSAYTRQILSGLNYLHQRNVVHRDIKCANILVDVSGSVKVADFGLAKATKLNDIKSCKGTPYWMAPEVVNRKNHGYGLAADIWSLGCTVLEMLTGRIPYSHLEGMQALFRIGRGEPPPIPNSLSRDAQDFILECLQVNPDARPTAAQLLNHPFVRKLPSAFPSPVSPHYSGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU03</accession>
    <name>A0A068TU03_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025759001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU03"/>
    <dbReference type="Gramene" id="CDO98828">
        <property type="protein sequence ID" value="CDO98828"/>
        <property type="gene ID" value="GSCOC_T00025759001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU03"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="131" mass="15240" checksum="E18B308E0D9D7C57" modified="2014-10-01" version="1">MIRKYRSNNELLKERKKEGISDGFSIYLMELKLELKLKFAERLKKSLDRVRLKGAQSHRWRESKSGGIRSATGPRVGDLEQELANYLSCLIQFTNLATETNFLKFANPPNELLLYVIGVHLRNLNINDNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU30</accession>
    <name>A0A068TU30_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00029481001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU30"/>
    <dbReference type="FunCoup" id="A0A068TU30">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU30"/>
    <dbReference type="Gramene" id="CDO99790">
        <property type="protein sequence ID" value="CDO99790"/>
        <property type="gene ID" value="GSCOC_T00029481001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU30"/>
    <dbReference type="OMA" id="DDDNWAS"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd12393">
        <property type="entry name" value="RRM_ZCRB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001144">
        <property type="entry name" value="U11/U12 small nuclear ribonucleoprotein 31 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000009">
        <property type="entry name" value="Zinc finger CCHC-type and RNA-binding motif-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034219">
        <property type="entry name" value="ZCRB1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO99790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="256" mass="28736" checksum="9D988C5224091EF2" modified="2014-10-01" version="1">MSRKRTHIDDDDDDDTFYHRYSSTAPPPTQLSSSSSGTNKRSGSGGLAPSKSTVYVSNLDYSLTNSDLHTIFSNFGKVAKVTVLKDRYSRQSRGVAFILFVSRDDAIKAVKGIDKKVLNGRTLTASIASDNGRAPEFIKKRVYKDKSRCYECGEEGHLSYECPKNLLGPRERPAPSKKGRRDGGGSGGGWGRREVEEEEEEEEMALFETDNWASVVDKGAEDRLLRGEEEVRKKKKKKKKEKRKGYFSDESDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU53</accession>
    <name>A0A068TU53_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029098001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDO99499">
        <property type="protein sequence ID" value="CDO99499"/>
        <property type="gene ID" value="GSCOC_T00029098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU53"/>
    <dbReference type="OMA" id="NETSNGW"/>
    <dbReference type="OrthoDB" id="738796at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040344">
        <property type="entry name" value="At3g17950-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33544">
        <property type="entry name" value="DUF4005 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33544:SF14">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="141" mass="15247" checksum="392F6D96A4D8A0E0" modified="2014-10-01" version="1">METRNGWPLGLGNINLRLRATLNFEAAAQAAPANELSSEMPSPSPSFTSFSSSNLDTESTASFFQDQSVPLGRLIGIKPASRGSLQFPSTNDFRQHRSLSSGRSNAEVSRNPGVETSQGLCVPLLHNVIEKMSRSKSTSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU76</accession>
    <name>A0A068TU76_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029130001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU76"/>
    <dbReference type="STRING" id="49390.A0A068TU76"/>
    <dbReference type="Gramene" id="CDO99519">
        <property type="protein sequence ID" value="CDO99519"/>
        <property type="gene ID" value="GSCOC_T00029130001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU76"/>
    <dbReference type="OMA" id="KDKANDM"/>
    <dbReference type="OrthoDB" id="6363407at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF24">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN (LEA) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="278" mass="31418" checksum="A04D21371585D933" modified="2014-10-01" version="1">MAAIPIAKKAAFNLSKAFPRSNYPLLYGKVSRVCFTTATKHSGGQYAEHADRRRDHDRDLYADKSDEDAAEMTKRARESVKESMGKTKERTQEMEEKAKEAAEKAKHRTESVAERAAEKAKEGKDWAADTAQETKEKAEDRADEMKEKTEDTAYEMKEKTKGAAETVAEKTKEGAYKVVETAETVGEKAKQTMKDAWGAAKETTQKIKETVVGKDDDDDKDRVEDFMEDHVRKPARKHRDIPVTEAPKGEHPDGVTMDEDVVELRRKAGQHDHHDKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUF6</accession>
    <name>A0A068TUF6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Equilibrative nucleotide transporter 3-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00029308001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUF6"/>
    <dbReference type="FunCoup" id="A0A068TUF6">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO99652">
        <property type="protein sequence ID" value="CDO99652"/>
        <property type="gene ID" value="GSCOC_T00029308001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUF6"/>
    <dbReference type="OMA" id="FWLLFIN"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUF6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF30">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOTIDE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO99652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46357" checksum="F776FC6F47556A42" modified="2014-10-01" version="1">MADMNGSPTPARLEGKLTAIVVCWVLGLGTLVAWNTMLTVGDYYYALFPRYHPARVLTLVYEPFALGTIAILAYKEAKIDTRKRNLAGFTLFFLSTFALLILDLATSGKGGIGNYIGICIIVAVFGIADAHIEGGMVGDLSLMCPEFIQSFFAGLAASGALTSALRIMTKAAFDKTNHGLRKGVILFLAISTFIELLCIFLYAFVFPKLPIVKHFRAKAASEGSKTVTADLAAAGIQTQAKNLLLSVKGDNDDKQLNRLSNKQLFFQNIDYALGVFLTYVLTLSIFPGFLYENTGNHKLGSWYAIVLIAMYNVWDLIARYIPLIECLKIESRKGLMVAILSRLLFIPAFYFTAKYGDQGWMIMLTSLLGLTNGYLTVCVFTAAPKGYKGPEQNALGNLLVLFLLGGIFAGVALDWLWLIGNGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWR1</accession>
    <name>A0A068TWR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032756001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWR1"/>
    <dbReference type="Gramene" id="CDP00705">
        <property type="protein sequence ID" value="CDP00705"/>
        <property type="gene ID" value="GSCOC_T00032756001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWR1"/>
    <dbReference type="OMA" id="FFRWAEA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWR1"/>
    <dbReference type="Proteomes" id="UP000295252">
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613:SF88">
        <property type="entry name" value="OS12G0152600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
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        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
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        </location>
    </feature>
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            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
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        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
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            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
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            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="690"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP00705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="85702" checksum="A4A37576801910B6" modified="2014-10-01" version="1">MHVILISVFIRQVLFFIRFMMTLYARASKSIISKNFLKVEVKLLFFASIHQSHCHPVFIGNTADLNSINFKDMSPVIYSVNKHSDSYFQNFILRTILEKPYVAGNSLWIFPDHYHADSELLIRVLNSIQEKPKVALKLFRWAEGKPGFKYSEFLFCTILDVLVQHGFMRSAYWVVERVVSVNLSSVMDVLIDGFLNSKVSVKVLDLALWVCTKKENVELCLLVFDKMMRNGLLPDVKNCNRILRVLRNRGFIGKAREVYRIMGKFGIKPTIVTYNTMLDSYCREGQVQEAVDLLSEMQRRGCFPNGVTYNVLINGLSKKGQFDQAKGLIQEMLNKGLTVSAYTYNPLISSYCANGMLVEALGLAKEMEMRGASPTLSTYNTLMYGLCKQGRVGDAWQWYPVVLKKNFVPDIVSYNILIYGYCRVGNAMAATFLLDELKRRKLIPTVVTYNTIIDGLCKLGNLEDARQLKDEMVDHGISPDVYTYTILVNGSCKAGRLSMAAEFFDEMLHKGLRPDCFAYTTRISSELKLGDASKAWTLQEEMLAKGFPPDMIVYNVFVGGICKMGNLNEAYAVLQKMVFDGLVPDHVTYTSIIHACLENGRVRKARELFHEMLSNGLSPTVVTYTVLIHAHAGLGRLELALMYFSEMQEKGIVPNVITYNALVNGLCKCRRLDQAYTYFSEMKTKGVIPNKYTYTILINGNIDLDNWMEALRLYIEMLDMGIKPDSCTHSALLKDLNKDYKLYAVQYLDYVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYL2</accession>
    <name>A0A068TYL2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00036412001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068TYL2"/>
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        <property type="protein sequence ID" value="CDP01385"/>
        <property type="gene ID" value="GSCOC_T00036412001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYL2"/>
    <dbReference type="OMA" id="CIRREGS"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYL2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47943:SF2">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47943">
        <property type="entry name" value="CYTOCHROME P450 93A3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP01385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30949" checksum="0C2DFA9387A58317" modified="2014-10-01" version="1">MMMIIHWLWATLALAGLCYFLQDLFLMKKRRGLPPGPKGLPIIGSLHLLRKNPHQDLAKLAKKHGPIMYLRFGCVPEIVVSSPEAAEKNLTFGQYGPYWRNMRKLCILQLLSSHKINSFRPMRKEEVGTLVKSLKQATSDGAAVDLSGLTSSLGANMSCLMIFGQRYMDKDFDDRGFGEVIQEALHVGSTPNICDYFPLLGVLDLQGLTRRFKAQANVFHDFFDKIIDEHLECKEQKQTKDFVAIMMEIIQSGTSEFEFDPRHVKAVLCVSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYN9</accession>
    <name>A0A068TYN9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Squalene monooxygenase</fullName>
            <ecNumber evidence="5 14">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00034984001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways. Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25283"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="5 14"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYN9"/>
    <dbReference type="STRING" id="49390.A0A068TYN9"/>
    <dbReference type="Gramene" id="CDP01371">
        <property type="protein sequence ID" value="CDP01371"/>
        <property type="gene ID" value="GSCOC_T00034984001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYN9"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYN9"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046246">
        <property type="term" value="P:terpene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000074">
        <property type="entry name" value="Squalene monooxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF15">
        <property type="entry name" value="SQUALENE EPOXIDASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="15">
        <location>
            <begin position="232"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP01371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="540" mass="58370" checksum="25FA39B662B80D8B" modified="2014-10-01" version="1">MASSIDVLITKLNNYIGFTGFMGIGIAFLLCFAVFLLDYLSFAAKKKIKDETRLKEESEARINNSVTDEGPISQGRAAGDPEIVIVGAGVAGAALACSLGKDGRRVLVIERDLSEPDRIVGELLQPGGYLKLVELGLEDCVEGIDAQRVYGYGLFKDDKRTKVSYPLENYRSDVSGRSFHNGRFIQRMRVKAAKTPNVRLEQGTVTSLIEENGTVKGVNYKTKVGKQITAYAPLTIVCDGCCSNPRRSLCNPKVDIPSSFVALVLKNCQLPYPNHGHVILANPSPILMYPISSFETRCLVDIPGRQKVPSIPTGEMAQYLKTVVLPQLPSEVHGAFISAIEEGDIKVATNRSMPATPCSTPGAILLGDAFNMRHPLTGGGMTVALSDIVVLRKLLKPLDDLNDAAGLNEYLEVFYSLRKPVASTINTLAGALYKVFTASDDQARAELRQACFDYLSLGGVFSNGPVALLSGLNPKPLTLVMHFFAVAIYGVGRLLLPFPSLKRALIGGKLIMDATGIIFPIVKAEGIKQMVFPVSIDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ70</accession>
    <name>A0A068TZ70_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00036701001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ70"/>
    <dbReference type="FunCoup" id="A0A068TZ70">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZ70"/>
    <dbReference type="Gramene" id="CDP01600">
        <property type="protein sequence ID" value="CDP01600"/>
        <property type="gene ID" value="GSCOC_T00036701001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ70"/>
    <dbReference type="OMA" id="CHEGREN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ70"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009809">
        <property type="term" value="P:lignin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000004">
        <property type="entry name" value="probable cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="24"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP01600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="361" mass="38702" checksum="E564ED30894B6A44" modified="2014-10-01" version="1">MARKSPEEEHPMKAYGWAARDSSGVLSPFKFSRRATLEDDVRFKVLYCGICHTDLHFIKNDWGISTYPFVPGHEIVGEVTEVGSKVTKVKVGDKVGVGYFLESCRSCENCSEGLENYCPKVVLTSGAPYHDGTKTYGGYSNEMVCNEHFIIRFPENLPLDGGAPLLCAGASVYSPMKYYGIAKPGSHIGINGLGGLGHVAVKFAKALGAKVTVISTSDRKKDEALNHLGADAFLISQNVEDMKAAAGTMDGILDCVSAKHPLVPLLGLLKSHGKLVTVGVPAQPLELPIAPLVVGRKLVGGSNVAGIAETQEMIDVAGKHNITADIELVSMEDLNTAMERLAKGDVRYRFVIDVANTLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ95</accession>
    <name>A0A068TZ95_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fiber protein Fb34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00032684001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DESIGUAL family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ95"/>
    <dbReference type="FunCoup" id="A0A068TZ95">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZ95"/>
    <dbReference type="Gramene" id="CDP00663">
        <property type="protein sequence ID" value="CDP00663"/>
        <property type="gene ID" value="GSCOC_T00032684001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ95"/>
    <dbReference type="OMA" id="QNEGLGM"/>
    <dbReference type="OrthoDB" id="2015495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ95"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009606">
        <property type="entry name" value="DEAL/Modifying_wall_lignin1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052222">
        <property type="entry name" value="DESIGUAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31769">
        <property type="entry name" value="OS07G0462200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06749">
        <property type="entry name" value="DUF1218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21067" checksum="21A16F6809881AE0" modified="2014-10-01" version="1">MGVSIPILVIITSLHLIAFVLAIGAERRRSTANVMPDKYDETTYCVYGTDASTVYGLSAFGLLLISQTVLNGVTKCLCFGKGMMGGRSTTCAVFFFIFSWVSFLGAEACLLAGSARNAYHTKYRGIFGGNDLSCATLRKGVFAAGAALTLLSMIGSIFYYWSHAKADTGGWEKQNTEGLGMTTSHYMENQQELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U114</accession>
    <name>A0A068U114_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2HC zinc finger plants domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034893001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U114"/>
    <dbReference type="FunCoup" id="A0A068U114">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U114"/>
    <dbReference type="Gramene" id="CDP01298">
        <property type="protein sequence ID" value="CDP01298"/>
        <property type="gene ID" value="GSCOC_T00034893001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U114"/>
    <dbReference type="OMA" id="QAVIMAM"/>
    <dbReference type="OrthoDB" id="436688at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U114"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056971">
        <property type="entry name" value="Znf-C2HC_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35513">
        <property type="entry name" value="OS02G0158600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35513:SF1">
        <property type="entry name" value="OS02G0158600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25017">
        <property type="entry name" value="zf-C2HC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2HC zinc finger plants" evidence="2">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="179" mass="19342" checksum="3C69EBC78F2E09BC" modified="2014-10-01" version="1">MNHGMDADMMEADSTASPPSPPPPRPPIPSDQSDVMTGLLSTARQLIQQGNPSQALHAVVIAMRMRGGEEAVYHALNRAGELYRNKVQESIAADELATLLAECALAEATPLNSQSSQHNKVDQSRELDVDGTSILAETGRKQIVLDAFSDGSSFVCLQCGGLVSNERKEEHYAFWCCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U246</accession>
    <name>A0A068U246_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00040034001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U246"/>
    <dbReference type="FunCoup" id="A0A068U246">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U246"/>
    <dbReference type="Gramene" id="CDP02596">
        <property type="protein sequence ID" value="CDP02596"/>
        <property type="gene ID" value="GSCOC_T00040034001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U246"/>
    <dbReference type="OMA" id="YSCYQRM"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U246"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20544">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000069">
        <property type="entry name" value="Cyclin-D5-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="181"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37945" checksum="D436A96B62766B55" modified="2014-10-01" version="1">METSQTTSSIPSLLCEEDESCFTLNNESDETLCQCCIFEYDDEYIEMLIHKESDLQSNTNKSLCNSSNDETDEQSWSKRARLHAVQWILDTRALFGLHFQTAYLSLIYFDGFFSKRSVEDGKLWAIRLLSIACLSLAAKMEEYKAPALSDYHIDECNFEGRLIQKMELLVLDALEWKMNVLTPFLYFRYFIAKFYGESRPKGLMSRAIELTLAMLKDISLVKYPPSMIAAVAVLAACDSQLTMKMLEFKLSIISSWGSSHKENVLLCYNLMREIQKAKSNTPNLQSPLSLSLKQSSSRDCRESSCIIGTKRRLAYPDSDQHQPLQRTRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2N6</accession>
    <name>A0A068U2N6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00037048001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MS5 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2N6"/>
    <dbReference type="FunCoup" id="A0A068U2N6">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2N6"/>
    <dbReference type="Gramene" id="CDP01873">
        <property type="protein sequence ID" value="CDP01873"/>
        <property type="gene ID" value="GSCOC_T00037048001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2N6"/>
    <dbReference type="OMA" id="AERNDNC"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2N6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044961">
        <property type="entry name" value="MS5/SDI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36326">
        <property type="entry name" value="PROTEIN POLLENLESS 3-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36326:SF7">
        <property type="entry name" value="PROTEIN POLLENLESS 3-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP01873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="480" mass="53276" checksum="D2E071B25EFEE786" modified="2014-10-01" version="1">MLQDMWNAPPGFRPTKSAPSSPAKPLGVSRTRSESFQVAHKVPVGDTPYVRAKNVQLVDKDPEKAIPLFWAAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLRSRCSDQAQEALDNILKLITVIKRCGRLDDQIGLLRHKLYLIQQGMAFNGKRTKTARSQGKKFQVSVEQEATRLLGNLGWALMQQHNYIEAEDAYRRALLIAADNNKMCNLGICLMKQGRIAEAKENLRRVKPAVADGPRGIDSHLKAYERAQQMLRDLESEMMNKGGDRVEQSKLFDAFLGSSAVWQPQPCKEQSNVSTAASSNHHRDEYADENISSNLIQNQMVPPVQKNVKSSAVYGNSLNIDAPPFYFSKSSKDPIGTQFPETLKRTRSGNAANSARAKTMGELMMISSLEPEQKVRKQSISPEKDPDRLADLLPDSKDFEEAILAAVLGSGDESGKFLESRNEAGVAQQKVDKRLKVFQDITLSLSPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3S2</accession>
    <name>A0A068U3S2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039580001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3S2"/>
    <dbReference type="FunCoup" id="A0A068U3S2">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3S2"/>
    <dbReference type="Gramene" id="CDP02243">
        <property type="protein sequence ID" value="CDP02243"/>
        <property type="gene ID" value="GSCOC_T00039580001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3S2"/>
    <dbReference type="OMA" id="RFPFKKF"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3S2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="225" mass="25500" checksum="2A11FC60FA98389E" modified="2014-10-01" version="1">MSLHSGLNHLPIEHMPLDNTIPLLVLVLGFLQVCLYIILDWDGKVYSFFLGSKSSTSSLQEQSSDGLKNSGVVGEEKKKKKKQKKNQVSEFLVKQQQPGFKVDKHDESVCGEDVKLVFTSLGLLGHHDHDGARIVEERLNCNDLFNLFEEKEPSEDEVKATFDVFDQNKDGFIDANELQRLLCALGLREGSELENCRRMITAVDEDGDDKIDFIEFVKFLENTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U498</accession>
    <name>A0A068U498_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">Protein LIKE COV 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00041864001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="GSCOC_T00041864001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U498"/>
    <dbReference type="OMA" id="TTGWYTL"/>
    <dbReference type="OrthoDB" id="534431at2759"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010222">
        <property type="term" value="P:stem vascular tissue pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="COV1-like"/>
    </dbReference>
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        <property type="entry name" value="COV-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876:SF15">
        <property type="entry name" value="COV-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29293" checksum="9A1D9B6F1AD30451" modified="2014-10-01" version="1">MGSTSRERDRELLIPVSDSVEADDDSSSKPSSSASSSHHHSGRETFYKVIRSWASKKFMTGCVILLPIAITFYITWWFIHFVDGFFSPIYAQLGIDIFGLGFVTSITFIFLVGVFMSSWLGASVLSLGEWFIKRMPFVRHIYSACKQISAAISPDQNTQAFKEVAIIRHPRIGEYAFGFITSSVILQNYSGEEELCCVYVPTNHLYIGDIFLVNSNDVLRPNLSVREGIEIVVSGGMSMPQILSTLDPRIVQVDRIRPDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4D2</accession>
    <name>A0A068U4D2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039853001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4D2"/>
    <dbReference type="STRING" id="49390.A0A068U4D2"/>
    <dbReference type="Gramene" id="CDP02468">
        <property type="protein sequence ID" value="CDP02468"/>
        <property type="gene ID" value="GSCOC_T00039853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4D2"/>
    <dbReference type="OMA" id="EMNIDLN"/>
    <dbReference type="OrthoDB" id="1908613at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4D2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044787">
        <property type="entry name" value="HHO5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058673">
        <property type="entry name" value="HHO5-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003:SF3">
        <property type="entry name" value="HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26575">
        <property type="entry name" value="HHO5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="42578" checksum="4DFD1E33C13CF602" modified="2014-10-01" version="1">MKFDSKEFRLLDLNSSGFVPKSISDLLAEVSMIPDIPLKLSKLNDYVCVLEQEMKKIDGFRRELPLCMLLLNDAIWKLKEEVVKLKKREVETVVMEEFMPLKGNSDREDERPKRKSADWTDKKTWMSSAQLWTTPIQYENERSDGAARWSLSDQARSFNKKLGGAFLPFKKPGGAVVTKTEEEEEEEDYPLNGLSLSMPALAEVGSDDLTNSKGKHVGVASDDGTGVLSEGGSSSQTTQGKKQRRCWSHDLHQNFVKALFELGGAQAATPKHIREIMQVDGLTNDEVKSHLQKYRLHIRKLMPSSSTSASPNYEWLRRGERSYLRKPSAKQSASPEGPLHLAGGGSAKGASVTGGDSMEEEEDRRSESCSWKDRHQKPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4D3</accession>
    <name>A0A068U4D3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00015146001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4D3"/>
    <dbReference type="Gramene" id="CDP03415">
        <property type="protein sequence ID" value="CDP03415"/>
        <property type="gene ID" value="GSCOC_T00015146001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4D3"/>
    <dbReference type="PhylomeDB" id="A0A068U4D3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="144"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="555"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP03415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="75256" checksum="635F21A9E163A10B" modified="2014-10-01" version="1">MAGALVDALLGSTTEVLVEKAINLASEQIGQFVGFKKDLEKLKDTLIGIQAFLRDAEKEQVTKEFVKRWLENLERVAFDAGNLLDDVNYEMIRRKVEIQNQMKRKVCLFFSLSNPIAFRLEKNRKTTSLFVDQTFVGRDGDVLEIVGRLTAPSNNENISVQPIVGMGGIGKTTLARQVFNDPKIVNHFAKRIWVCVSDDFDVDRLFDFMLESLGGQKPGGGVRQLEAKVQDLKNLLDDKKFLLVLDDVWDKESTRWNWNEFLGSLRGTSQAMGSWILVTTREQQVVDITRISSPQGYSLKQLSDDQCWHILKENAFCGGEVPDGLQDIGLKIAQRCRGLPLAASVLGGMLRNKEPDEWQSLESGFQSLGGDENVDVTNTILKLSFDHLPHPSLKKCFAYCSIFPKDFQMERNELIQLWAAEGFLHSNPRNDMHMEEVGNRYFTILLDSNLFQDAEKDDYGNVLNCKMHDLVHDMVQSISNSKTLRLTESGSVLMETSSIRYLALERSEKEMTFSSTESFKQLHSFLDLFDALPPPHPYFPFLSWLLLYGWPHWESLPEQLQHLSALTTLALSDFGVKSLPDWFGKLSSLEELELSNCRKLENLPSHQSMRSLTRLRKLWITHCPLLKERCDPESSSTDPNSERSKISHIPTIVIDWENIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5A8</accession>
    <name>A0A068U5A8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041922001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5A8"/>
    <dbReference type="FunCoup" id="A0A068U5A8">
        <property type="interactions" value="1617"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5A8"/>
    <dbReference type="Gramene" id="CDP03364">
        <property type="protein sequence ID" value="CDP03364"/>
        <property type="gene ID" value="GSCOC_T00041922001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5A8"/>
    <dbReference type="OMA" id="SENWAVK"/>
    <dbReference type="OrthoDB" id="1925343at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5A8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010048">
        <property type="term" value="P:vernalization response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058585">
        <property type="entry name" value="Fn3_VIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032881">
        <property type="entry name" value="Oberon-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044514">
        <property type="entry name" value="VIN3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056990">
        <property type="entry name" value="VIN3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286:SF1">
        <property type="entry name" value="VIN3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286">
        <property type="entry name" value="VIN3-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23376">
        <property type="entry name" value="Fn3_VIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07227">
        <property type="entry name" value="PHD_Oberon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23380">
        <property type="entry name" value="VIN3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="331"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="682" mass="75372" checksum="4D8BAE1398899F6C" modified="2014-10-01" version="1">MDLEDKFLAKVSGIQSLSSSVHSTPEKNGQSDDASRSPKVLQEFLKSGARKDLLHTCLEKEKKQSASSKCKMSEPATKISKKPIKNQDQKKTASSPKDQPLKKQNRKAENPVRIPPTTEQCADFKCSNSWICKNSACRATLSIEDTFCKRCSCCICHLFDDNKDPSLWLECASESGQGDYCGLSCHIECALQRGKVGVVDLGQLMQLDGSYCCAACGKVSGILGYWKKQLNIAKDARRVDVLCYRIFLSYRLLDGTSRFKELHEIIKEAKAKLETEVGPVNGVSAKMARGIVSRLSVAGNVQTLCSLAIEKADEWLTSKSSATADYREGSLPAACRFLFEEVTSTSVVIVLIELSSVSSNDVKGYKLWYCKSREENYTKEPVCVFPRAQRRILISNLQPCTEYSFRIVSYMEGGDLGHSEAKCFTKSREIIHKNSNSVAENHSHRKENPDSGGSSSAEMEHRTPTAIESDSGFKVRDLGKILRLAWAQEQGCFERFCGADIVRCSSVSKVIKPESIQEDVPSVSRELDLNVASVPDLNEEAAPLIESSRDEDNVSHDIEKNGVARSHGSGDSQNWNHGQNGEVPAVDSKVEASRKRAASNGETHDSDSTLINGSPFRVRNGPGCLDENFDLRSTDQERRVVNTFIQTLLDDPSSLAGQLVDSFTDIISSKRPRNGFCSRLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5V3</accession>
    <name>A0A068U5V3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00015959001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5V3"/>
    <dbReference type="FunCoup" id="A0A068U5V3">
        <property type="interactions" value="1125"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5V3"/>
    <dbReference type="Gramene" id="CDP03554">
        <property type="protein sequence ID" value="CDP03554"/>
        <property type="gene ID" value="GSCOC_T00015959001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5V3"/>
    <dbReference type="OrthoDB" id="41419at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5V3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36776">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36776:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP03554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="19858" checksum="F4F9D662D4BE7A26" modified="2014-10-01" version="1">MGSVLFSNPTLIMAELKYVGHYKIGNSGSLILYFKPKFHHKHELRLSRFPSLLSPSNTQYNIEGDPEEDSVQHLRVPSSWLDPSQALEESEWLRATLHKWLDDEYCPEETNIKISEVASHSFYKSLMEKKTDLGEILLEMAQELGSVSYQESFHGAFSSANAAVDLIIQRIQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6I9</accession>
    <name>A0A068U6I9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00016442001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6I9"/>
    <dbReference type="FunCoup" id="A0A068U6I9">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP03932">
        <property type="protein sequence ID" value="CDP03932"/>
        <property type="gene ID" value="GSCOC_T00016442001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6I9"/>
    <dbReference type="OMA" id="KQFETWI"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6I9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF2">
        <property type="entry name" value="OS06G0184866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43953" checksum="EA8218E6EFD3D620" modified="2014-10-01" version="1">MKLIPRNSLISILRTSLSSLSFRPISNTASDHPAETLTPSPPISQNPYAKPNPHPRTRTPSEKQFEKWIQNLKPGFTPSDVDEALNAQTDPDLALDIFRWTAQQRGYKHDQVTYLTMIEIAATGKRYRVAETLIEEVVAGACPPSLPLYNSMIKFCCGRKFLFNRAFDIYKKMLKCDDPTVKPSLETYTLLLNSLLRKFNRLNVCYVYLHAVRSLTKQMKASGVIPDTFALNMIIKAYSKCLEVDEAIRIFREMGLYGCEPNAYTYSYIAKGLCEKGRVAQGLNFFKETREKGFVPKGSTYVILICSLALERRFEDAIEIVFDMLDNSMSPDFLTYKTLLEELCRDGRGNDAFELLQEMWKRDTSMNEKTYSALTNVLHFLNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U731</accession>
    <name>A0A068U731_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00015161001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U731"/>
    <dbReference type="Gramene" id="CDP03423">
        <property type="protein sequence ID" value="CDP03423"/>
        <property type="gene ID" value="GSCOC_T00015161001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U731"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP03423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="57" mass="6548" checksum="FD8FAD22E2A3D67C" modified="2014-10-01" version="1">MRSDEVFLNQELFLFGIFCRFLKEDTLTPKGPSTYGRKLLNGGRAWNRHYIGVTGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U835</accession>
    <name>A0A068U835_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016230001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U835"/>
    <dbReference type="STRING" id="49390.A0A068U835"/>
    <dbReference type="Gramene" id="CDP03753">
        <property type="protein sequence ID" value="CDP03753"/>
        <property type="gene ID" value="GSCOC_T00016230001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U835"/>
    <dbReference type="OMA" id="LYCGMLF"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U835"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF54">
        <property type="entry name" value="INACTIVE LYSINE-SPECIFIC DEMETHYLASE JMJ19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="354"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP03753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="87939" checksum="FB7BAE3532456110" modified="2014-10-01" version="1">MTEDTRSMINDKVEKLSVPPGFVSLSSFTLKNLSSNEVACSSMAVGDAFQTELSPVGFTPTMDNIAMFKSNLSHRPWILYNQFDYKSNESDSELEMNFPLRACLPKGVVRGCSSCPNCQKVTARWHPEESHRPVLEEAPVFQPSEEEFKESLEYVARIRQKAEQFGICRIVPPPSWKPPCLLKERNIWETSKFKTHIQLVSDLQDQGIKRNLDRSHKEAKIKRRRVWMRSSGDGSLNEISTDANEVQSEAESFISKLGPELTLEAFNRYADDFKRQYFCKRENAINSDANLTVHEDGWEPSVENVEGEYWRIIENPIEEIEVLCCANVETGGFGSGFPVHSNSMGLPNYPEYCDSCWNLNNIFKLPGSLLGYENRQTSAALLPHLSSGMCFSSVCWKAEEHHLYSLSYIHFGSPKIWYVIPGGYCYRFERVVKKHLPHCLEHPELLYKNISQLSPSTLTAEGIPVYRCVQYPGEFVVTFPAAYHSQFDCGFNCSETVNFAPFDWLPYGQHVVEMYCEQGRKTLISHDKLLLGAAMDAVREKWKCELLKKNASVCGKDGILTKALKLRVKQEAIRREYLCRGLQLQKMEDDFDSDKRDCSTCLYDLHFSAIGCSCSPGRYACLLHAKNLCPCHWTARYLLYRYEISELNLLVQALEGRLDAIYHWGKKKLDLRVSSDDLRELRNRGEVSASVKSAATSTLSQLLGPKELVTGQVCRKEEEEKYDLQKISAGSGSRQDTQECIDPNFGNITSKKGKFDKSQTVQNEVIVLTDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8D7</accession>
    <name>A0A068U8D7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00018797001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8D7"/>
    <dbReference type="FunCoup" id="A0A068U8D7">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8D7"/>
    <dbReference type="Gramene" id="CDP04726">
        <property type="protein sequence ID" value="CDP04726"/>
        <property type="gene ID" value="GSCOC_T00018797001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8D7"/>
    <dbReference type="OMA" id="VINHEWS"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8D7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF356">
        <property type="entry name" value="PROTEIN TRICHOME BEREFRINGENCE-LIKE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="136"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP04726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="420" mass="48027" checksum="006F1006D54D6EFB" modified="2014-10-01" version="1">MSSLSRTASLKQRTQIVGSPRAVASPRISRKSWNSEPVLIGIVIGLVVSFFLAVGLRYLYVLPSLTQAFHDDSVSHLNDSGNSCDVFDGNWVLDHRYPLYNASECPFVEQGFNCLENGRMDKEYLKWRWKPENCDIPRFNVMSILEMFRNRRIVFVGDSMSRTQWESLICMLMTGVEDKRSVYEVHGSKITKQIRFLGVRFSSFNFTIEFYRSVFLVQHSWAPKHGPKRVRSTLKLDELDDISDEWINTDVLIFNSGQWWVPGKLFGTGCYFQIGNSLKLGMSIGTAFRTALGTWSSWVDTRINPNRTRVFFRTFEPSHWSGDETLRLCNMTSQPLSETEGKDSSPFSDTVFDVVKNMAVPVTVLHITPLSAFRRDAHVGIWSDKPNMSDCSHWCLPGVPDIWNEILFHLLPGFKDASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U994</accession>
    <name>A0A068U994_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020073001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U994"/>
    <dbReference type="Gramene" id="CDP05130">
        <property type="protein sequence ID" value="CDP05130"/>
        <property type="gene ID" value="GSCOC_T00020073001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U994"/>
    <dbReference type="OrthoDB" id="662136at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U994"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32096:SF80">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 27-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32096">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 30-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="270" mass="30124" checksum="3B2E7657B1D19A8C" modified="2014-10-01" version="1">MADDWDLYAVVRSCFNAAATSTASSSTTTDAAIAPVENSSLPSGETSLSSSFLASPSFQSGHTSSDFPGFANHTRDSFRGLEEIYKEPYEDIVQSFVDLNSQAQHIQAIQGPGCTADQTPQQQRIYGQPQQLMQQPQRYSHLSREMFVGASLSFPSTSPQPERPRRRKNQQAKRIQQMTQEELSADSWAWRKYGQKPIKDSPYPRNYYRCSTSKGCTARKQVERCPADPSMYVVSYSGEHSHPRPTHRSSLAGTTRSKPLLPVSLQPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAH3</accession>
    <name>A0A068UAH3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="6">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020564001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
            <location evidence="6">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Secreted</location>
            <location evidence="6">Extracellular space</location>
            <location evidence="6">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="6"/>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAH3"/>
    <dbReference type="FunCoup" id="A0A068UAH3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAH3"/>
    <dbReference type="Gramene" id="CDP05491">
        <property type="protein sequence ID" value="CDP05491"/>
        <property type="gene ID" value="GSCOC_T00020564001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAH3"/>
    <dbReference type="OMA" id="CACHVLV"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAH3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103896" description="Xyloglucan endotransglucosylase/hydrolase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="366" mass="41852" checksum="B5B0E792ABE3BBF2" modified="2014-10-01" version="1">MVNFHLGFFALTTFIVLVCGASKNLPILSFDEGYSQLFGDDNLMVIKDGKSVHLTLDERTGSGFVSQDIYSQGFFSASIKLPADYTAGVVVAFYMSNGEMFQKNHDEVDFEFLGNIRGKDWRMQTNIYGNGSTNAGREERYGLWFDPSEDFHQYSILWTEDQIIFYVDNVPIREFERTATMGGDFPSKPMSLYATIWDGSDWATNGGKFRINYKYAPYIAKFSDLVLHGCAVDPTEQATKCDIAPKHDSIPTGITPEQRIRMQSFRKKHMQYSYCYDRARYTVPPAECVLDAEEAEGLRAFDPVTFGGAHRHRGKRHHRSRSSSSSFPINIFNRWSYYYIETCGGVNVFQFLKGYCLWGKKNDIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAV0</accession>
    <name>A0A068UAV0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00018827001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAV0"/>
    <dbReference type="Gramene" id="CDP04743">
        <property type="protein sequence ID" value="CDP04743"/>
        <property type="gene ID" value="GSCOC_T00018827001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAV0"/>
    <dbReference type="OMA" id="EVICIHA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAV0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27835" checksum="C7FC4C67E5C8B4EA" modified="2014-10-01" version="1">MIIPEKNRREISKYLFQVPVFYFEEVICIHAPMHALIHEIHWNSPSCFPPVFNCLSKALLLPTATVASEAASYSQVLDKWLDIRTLKKIHCRIILHLNLNSCISFGIKLMRAYAARGQTSITCQIFDRIPERNVVIFNVMIRSYVNNHLYHDALFMFKSMNSSNTNPDYYTFPCILKACFASMDLRVGLQVHTQVLKMNLDGNLYVGNGLIAMYEKCGSLTGACSVLDEMPRRDVVSWNSMVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB39</accession>
    <name>A0A068UB39_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00020862001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB39"/>
    <dbReference type="FunCoup" id="A0A068UB39">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB39"/>
    <dbReference type="Gramene" id="CDP05671">
        <property type="protein sequence ID" value="CDP05671"/>
        <property type="gene ID" value="GSCOC_T00020862001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB39"/>
    <dbReference type="OMA" id="NVHTNIM"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB39"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF18">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="202"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP05671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="509" mass="56818" checksum="4309A53C67C36F2B" modified="2014-10-01" version="1">MSSSSFKEIPAMAYPRTLVSIVASAGGLAVFLLIASSLLISGPIGSTFSSYFYGVVDHTEKDDLLSSGDGSGNRDAFEAFRSNLTIRNNSDSGDAVVESQVGEMKPGDSRNMRGQEKVVNVTNNAEKVSTNVQKNNTNGANLTDSVNTDCDLYAGKWVYDSTGPLYTNSSCPVLTQMQNCQGNGRPDKEYENWRWKPAQCNLPQFDAMKFLELMSGKTLAFVGDSVARNQMESLLCILWQVEVPKNRGNKKMQRYYFRSTSTMIVRIWSSWLVHQTPEPFDFAPTGVDKLHLDLPDERFMEFVPNFDVIVLSSGHWFAKKSVYILNNEIVGGQLWWPDKSRQMKVNNVDAFGISVETIVTAMLKHPNYTGLTILRSFSPDHYEGGAWNTGGSCTGKEKPAVDKDLVENGFTNIMHEKQVAGFNKAIKKQTNKSKAILMDITKAFSYRHDGHPGPYRSPDPNKITKRGPDGRPPPQDCLHWCMPGPVDTWNELVFEILRREFVAKKSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBV9</accession>
    <name>A0A068UBV9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00020991001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.58"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBV9"/>
    <dbReference type="FunCoup" id="A0A068UBV9">
        <property type="interactions" value="3225"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBV9"/>
    <dbReference type="Gramene" id="CDP05727">
        <property type="protein sequence ID" value="CDP05727"/>
        <property type="gene ID" value="GSCOC_T00020991001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBV9"/>
    <dbReference type="OMA" id="HRHTIID"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBV9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000004">
        <property type="entry name" value="Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP05727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="343" mass="39283" checksum="A3BF1B1C1EA13BE8" modified="2014-10-01" version="1">MDVLQKSSERIPLSQRPEYADVKPVAQDDGPNPIVPISYTDEFRETMDYFRAIYVTDERSLRALQLTTEVIKLNAGNYTVWQFRRLVLEALNADMNKELDFVDGIVEGNSKNYQIWHHRRWVAENLGTDPSTRELEFTKKILSKDAKHYHAWSHRQWVLQALGGWKDELAYCELLLKDDIFNNSAWNQRYFVVTRSPLLGGLGAMRESEVTCTVNAIMEHPENESPWRYLRGLYRNDTQALVQDPQVASVCLKILTAKNNYVHALSMLLDLLCHGFQPSLEIRNAVYGLSDSGAQGSDLVKVVCSILELVDPMRANYWKWRRNMAPAQAAQCLKDDGLTGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCY3</accession>
    <name>A0A068UCY3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wound-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00023253001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCY3"/>
    <dbReference type="FunCoup" id="A0A068UCY3">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCY3"/>
    <dbReference type="Gramene" id="CDP06415">
        <property type="protein sequence ID" value="CDP06415"/>
        <property type="gene ID" value="GSCOC_T00023253001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCY3"/>
    <dbReference type="OMA" id="QHMMRIL"/>
    <dbReference type="OrthoDB" id="1922476at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009798">
        <property type="entry name" value="Wun1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33703:SF16">
        <property type="entry name" value="OS05G0342100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33703">
        <property type="entry name" value="OS07G0691300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07107">
        <property type="entry name" value="WI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17573" checksum="3BD8B3B586C7D859" modified="2014-10-01" version="1">MAEKEPEISVLEQNNGNEATVKALYKALASGEIGKVAGFVASDLEWWFHGPQGCHHMMKMLTGKSSHKAFSFNPRSMDAIDDYVIVEGWEGVQAYWVHVWTLKDGLITQFREYFNTWLTVADLRPVAVAGGCSSSKFWQSHPRDLAKRSLPGLMLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UET1</accession>
    <name>A0A068UET1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc/iron-chelating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">cv. DH200-94</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
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    </evidence>
    <sequence length="185" mass="20666" checksum="154EC5183B881F9C" modified="2014-10-01" version="1">MSRAGLVALPSFNAVGSADNKPRLKPETETQKFINHGQKPIDISATNSSNLGLGLGLGFGNKKREPLWQCIQNCGACCKLNKGPTFPSPEEIFDDPSDIQQYKSLIGPDGWCIHYEKTTRKCSIYADRPYFCRVEPDIFQTLYGIDKKKFNKEACSCCIDTIKAIYGSKSEELNNFKHAIWETSS</sequence>
</entry>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
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                <person name="Perrotta G."/>
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                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
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                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Giuliano G."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="9571" checksum="4D43016683F45F2D" modified="2014-10-01" version="1">MPRMVAQFGYGGASKYISIGQANIGTCPVQARHRRSTTNSRRVGFASLVNKHISISRQEFEFEFVILSSSSGRNFAEVGSCDSAVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
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                <person name="Lepelley M."/>
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                <person name="Priyono X."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Jayarama X."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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        <source>
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    <sequence length="72" mass="8390" checksum="BF4DCDF4EBA8C8FD" modified="2014-10-01" version="1">MASTLDESIYKINMDGTFFEAGIGIRFVVRNQWLRRFPELSILGRWNALTFLKALQFAKNFGVSHSFWNLSM</sequence>
</entry>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
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                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH78"/>
    <dbReference type="FunCoup" id="A0A068UH78">
        <property type="interactions" value="1627"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UH78"/>
    <dbReference type="Gramene" id="CDP07612">
        <property type="protein sequence ID" value="CDP07612"/>
        <property type="gene ID" value="GSCOC_T00024922001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH78"/>
    <dbReference type="OMA" id="RARIFCK"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000357">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF12">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="191"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="598" mass="66051" checksum="9289A58C18CF33CC" modified="2014-10-01" version="1">MSDEKLKKSNSFQGILGKSSDDLVRRSSKSPTYRRRGFFNGLNVEGVRRDFTVNIPARSAPSSGFSSPALSPRFSTVDFHYPFRASSALETSPQDRVTGSPPPLLPTKLPCSPDHSPVRSPTSQNPCMNVRKNNGAALHSYHKSHSETWFDGNNANVHPLPLPPGVLRPSQSSLTYQNVDKSDVSPVIAQWKKGKLIGRGTYGSVYVATNCKTGALCAMKEVDLVPDDSKAQECIKQLEQEIKVLRQFKHPNIVQYYGSGTIEDRFCIYLEYVHPGSINKYVRDHCGAMTESIVRNFTRHIVSGLAYLHSKKTIHRDIKGANLLVDANGVVKLADFGLAKHLTGHATDLSLKGSPHWMAPEVLQAAMRKDTNSELAYGVDIWSLGCTVIEMLTGKPPWSEFNGVQAMFNVLHRSPHIPETLSPEGKDFLQRCFQRRPEDRPSAAVLLGHAFLRNSCDQNVASCLEEFSGVTLSDKPQSPKDSIERTKNLMSDLPSLSVKNREVPHNSECLQSSPQVSDFGFASRQSPCSTLDVSSPELNSTSRNISPPDICNSLPAGTGINKRPFDNIYVFGCSVDRKKVTKQCFGKHEGGKTPRWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHB6</accession>
    <name>A0A068UHB6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Disease resistance protein winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025505001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHB6"/>
    <dbReference type="STRING" id="49390.A0A068UHB6"/>
    <dbReference type="Gramene" id="CDP07960">
        <property type="protein sequence ID" value="CDP07960"/>
        <property type="gene ID" value="GSCOC_T00025505001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHB6"/>
    <dbReference type="OMA" id="CPRRIWE"/>
    <dbReference type="OrthoDB" id="1935686at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHB6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1185">
        <property type="entry name" value="DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="5">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="14898" checksum="A2E9AF9A7BD87090" modified="2014-10-01" version="1">MEKLGKKILKNCGGLPLAVVVLGGILKTKKSLREWNAVHENIKSYLDRGEKFRKEGEVSKVLAYSYYDLPWQLKPCFLYLGKFREDSDIGVESLYQMWIGEGMIFDNDRTRQEPMMDVAERYLEELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI20</accession>
    <name>A0A068UI20_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="12">HMG-CoA reductase</shortName>
            <ecNumber evidence="12">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00024470001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="12"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI20"/>
    <dbReference type="FunCoup" id="A0A068UI20">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UI20"/>
    <dbReference type="Gramene" id="CDP07253">
        <property type="protein sequence ID" value="CDP07253"/>
        <property type="gene ID" value="GSCOC_T00024470001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI20"/>
    <dbReference type="OMA" id="VCEAMIS"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI20"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:saponin biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
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    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP07253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="572" mass="60875" checksum="4887EB4C9057F663" modified="2014-10-01" version="1">MDVRRRPPKPSGPPTNSLDHQQNKGSSSASARVLDRSPSPTPKASDALPLPLYLTNCIFFTLFFSVAYYLLHRWRDKIRNSTPLHVLTLSDLAAILSLIASFIYLLGFFGIDFVQSFIARPSNDHWDVDGPPPTTTTPLGISHPPCPKEEEADEELVNSVVSGDIPSYSLESTLGDCLRAASIRREAVQRITGRSLSGLPLDGFDYDSILGQCCEMPVGYVQIPVGIAGPLLLNGCEYSVPMATTEGCLVASTNRGCKAIYASGGATGILLRDGMTRAPVVRFPTAKRATDLKFFLEDPLNFDTLALVFNKSSRFARLQGIQCSIAGKNLYIRFSCSTGDAMGMNMVSKGVQNVLDFLRSDFCDMDVIGISGKCSVRNFCSDKKPAAVNWIEGRGKSVVCEATISEEVVNKVLKTTVPALVELNMLKNLAGSAVAGALGGFNAHAANIVSAVFIATGQDPAQNIESSHCITMMEAVNNGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASKESPGSNARLLATIVAGAVLAGELSLMSAIAAGQLVKSHMKYNRSSRDVTKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIH9</accession>
    <name>A0A068UIH9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1230 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027028001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068UIH9"/>
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        <property type="gene ID" value="GSCOC_T00027028001"/>
    </dbReference>
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    <dbReference type="OMA" id="MWVKTAE"/>
    <dbReference type="OrthoDB" id="192326at2759"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009631">
        <property type="entry name" value="CGLD27-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34214">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34214:SF1">
        <property type="entry name" value="DUF1230 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06799">
        <property type="entry name" value="CGLD27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
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            <begin position="137"/>
            <end position="157"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="71"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29506" checksum="314EE19B0FB12205" modified="2014-10-01" version="1">MATTLFHSPKPPLVQAPPATSYQLTTPFTKISSIPRAQTIPKTNLHSRLPSASFRNSSSIPPESSETGGGCPVPLDQQPINEYKALSNSFPFSWASAGFVEYSSRLFVAGAAFAVLVGLPVSWFGSVGPESDPIKRVLAGVSSGILVMTLLVVRMYLGWAYVGNRLLSATVEYEETGWYDGQMWVKTAEVLARDRLLGSFSVKPVLSRLKNTLVTLAVSLFICVVIFLNVEGSQDRSYKTSEEAGGRAVPGVYNDESARTFEPDAFCGEPAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIL2</accession>
    <name>A0A068UIL2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aminopeptidase</fullName>
            <ecNumber evidence="18">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00027092001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16 18">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="18"/>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIL2"/>
    <dbReference type="FunCoup" id="A0A068UIL2">
        <property type="interactions" value="2731"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIL2"/>
    <dbReference type="MEROPS" id="M01.A25"/>
    <dbReference type="Gramene" id="CDP08301">
        <property type="protein sequence ID" value="CDP08301"/>
        <property type="gene ID" value="GSCOC_T00027092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIL2"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIL2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000009">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000007">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0492">Microsome</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="21">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="19">
        <location>
            <begin position="244"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="20">
        <location>
            <begin position="538"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="882" mass="99173" checksum="082E053E1CDF423E" modified="2014-10-01" version="1">MAEKETTNSKYQQFKRQPRLPKFALPKRYDLKLKPDLTACKFSGAVDISVDVVSDTKFLVLNAADLSVRANSVHFTSSSNKAFDAVAVELCEEDEILVLEFAESLPIGVGNLSIAFDGTLNDRMKGFYRSVYEHNGEKKNMAVTQFEPADARRCFPCWDEPACKATFKITLEVPSELVALSNMPILEEKVNGNLKTVSYQESPIMSTYLVAVVVGLFDYVEDQTPDGVVVRVYCKVGMVDQGKFALDVAVKTLGIYKEYFALPYSLPKLDMIAIPDFAAGAMENYGLVTYRETALLYDDKHSAAANKQRVATVVAHELAHQWFGNLVTMEWWTHLWLNEGFATWVSYLAADALFPEWQIWTQFTDESTEGLRLDGLSESHPIEVDINHAAEIDEIFDSISYRKGASVIRMLQSYLGAECFQRALASYIKKYACSNAKTEDLWSVLEESSGEPVNKLMNSWTKQKGYPVVSAKLKDQILELEQSHFLLSGSPGDGQWVVPVTLCCGSYDSRKSFLLQAKSEAHDIKELLGASVSKSSSWVKINLDQAGFYRVKYDDDLSARLRHAIEKKYLSTMDRYGILDDSYALSMACQQSLASLLALMGAYKEEIDYTVLSNLISISAKVVRVAADAVPHLLDNIKLFFINLFQYSAGRLGWDPKPGESHLDAMLRGELLTALALFGHEETQKEASRRFSIFLDDRDTPVLPPDLRRAVYVAVMQKVNKSNRSCYDSLLRVYRESDLSQEKTRILGSLGSCQDPEVILEILNFLLSSEVRSQDVVHGLGVSREGREIAWKWLKDNWDQIVKTYGAGFLVTRFISAVVSPFSSCEKAAEVEEFFASRMKPFIARTLKQSIERVLINAKWVHSIQNEENLEDVVTELACRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ98</accession>
    <name>A0A068UJ98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027064001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
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            <text>GTP + H2O = GDP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
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            <dbReference type="Rhea" id="RHEA:19670"/>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="812" mass="90506" checksum="9B0946941D0C40FF" modified="2014-10-01" version="1">MDYKHNIRNMSVIAHVDHGKSTLTDSLVAAAGIIAQEVAGDVRMTDTRADEAERGITIKSTGISLYYEMTDEALKAYKGERQGNEYLINLIDSPGHVDFSSEVTAALRITDGALVVVDCIEGVCVQTETVLRQALGERIRPVLTVNKMDRCFLELQVEGEEAYQTFQKVIENANVIMATYEDPLLGDVQVYPEKGTVAFSAGLHGWAFTLSNFAKMYASKFGVDESKMMERLWGENFFDPATKKWTSKNTGSPTCKRGFVQFCYEPIKQIISTCMNDQKDKLWPMLSKLGVTMKSDEKELMGKALMKRVMQTWLPASSALLEMMIYHLPSPAKAQKYRVENLYEGPLDDQYANAVRNCDPEGPLMVYVSKMIPASDKGRFFAFGRVFSGKIATGMKVRIMGPNYVPGEKKDLYVKNVQRTVIWMGKKQETVEDVPCGNTVAMVGLDQFITKNATLTNEKEVDAHPIRAMKFSVSPVVRVAVQCKVASDLPKLVEGLKRLAKSDPMVVCTIEESGEHIIAGAGELHLEICLKDLQDDFMGGAEIIKSDPVVSFRETVLEKSCRTVMSKSPNKHNRLYMEARPLEEGLAEAIDDGRIGPRDDPKNRSKILSEEFGWDKDLAKKIWCFGPETTGPNMVVDMCKGVQYLNEIKDSVVAGFQWASKEGALAEENMRGICFEVCDVVLHADAIHRGGGQVIPTARRVIYAAQLTAKPRLLEPVYLVEIQAPEQALGGIYSVLNQKRGHVFEEMQRPGTPLYNIKAYLPVVESFGFSGTLRAATSGQAFPQCVFDHWDMIKRKGLKDQMTPLSEFEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJH1</accession>
    <name>A0A068UJH1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027182001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="49390.A0A068UJH1"/>
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        <property type="protein sequence ID" value="CDP08374"/>
        <property type="gene ID" value="GSCOC_T00027182001"/>
    </dbReference>
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    <dbReference type="OMA" id="SCITDSH"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007142">
        <property type="term" value="P:male meiosis II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="JASON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33318">
        <property type="entry name" value="ASPARTYL/GLUTAMYL-TRNA(ASN/GLN) AMIDOTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33318:SF7">
        <property type="entry name" value="PROTEIN JASON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="430" mass="48618" checksum="B7DE284442557736" modified="2014-10-01" version="1">MMQACRTLRETPANFCQAPEKWNNLSAQKGGSENSRCRSWITNTSVEERDLEVKFEQPLTPVKCCGRWVKVSGSLEHKSSSCMTNRQNAGRVSTSSTEGKEIEDAGSVELIASSRNGLTGSLATPRDISPFIIGENKSVEFDCYSDTSSVTSENYSSETSTQSLNQSGSASNLSTANSSCYPTPIKLSDKMQTSGIVFPVYLDAFGQDKNTRITSLYLYSVLNPVENFSQWKQLKNEDTNDHQNSHIKEPCVRVDKETPMSDVGTGGTSAGQELKVEASWSSWSSWPRALFRDPDGDPEHNEFAAGENSHCRRIQVDRSILGMDASDWDKDESHVSPKWWNGNGVPNSTDKYKEVWAMCWIKFQGRIHKCKEVSPKWWDGNGIPNTTHKYREDRKVCWHETPFEERLEKALFEETFIRQRYAWLLVPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJM9</accession>
    <name>A0A068UJM9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00027773001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Noel B."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Bernard M."/>
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                <person name="Da Silva C."/>
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                <person name="De Bellis F."/>
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    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="136"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="649" mass="71601" checksum="64C483CF0862577A" modified="2014-10-01" version="1">MSGKKERSSTSTSRSPPTMSHHSSPPRRHPLPLVVTLNCIEDTTLESDCLAGVASVEHVSLSRLADARIESAAAVLLHSLAFLPRAAQRRLRPWQLILCLGSSDRSVDSALAADLGLNRLFHVDVSRAEEVADTVMALFLGLLRRTHLLSRHALSASGWLGSVQPLCRGMRRCRGLVLGIVGRSASARSLATRSLAFRMSVLYFDVDEGNGKLSRSLNFPSAARRMDTLNDLLAASDLISLHCSLTNETIQIINADCLQHIKPGAFLVNTGSSQLLDDCAVKQLLIDGTLAGCALDGADGPQWMEAWVREMPNVLILPRSADYSEEVWMEIREKAISILQSLFVDGINPRDSVSDEEELENEVGHDRVETQDSESALQSSVCEQLTSDIHLNAESSQKKASNPSKESSGQHQGPVSSQGTSSRTEAKRSRSSKKTKRRHARQKSQHKIEEHMTHERESTSHHEDDTAMSGTDQVLSSNSRFASPEDSRSRKTAIESIQESSAEQLLKASREFTKKSGELLKDGFVVALRPRDQHALYVSRQRVQGGAWFLDTVPNVAKRDPAAQFLVDFRSKDAIGLRSFTAGGKLLQINRKMEFVFASHSFDVWESWTFEGSLEECRLVNCRNPLAVLDVHIEILAAVGEDGITRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL93</accession>
    <name>A0A068UL93_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="8">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027214001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739116">
        <property type="protein sequence ID" value="CDP08388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL93"/>
    <dbReference type="FunCoup" id="A0A068UL93">
        <property type="interactions" value="2909"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL93"/>
    <dbReference type="Gramene" id="CDP08388">
        <property type="protein sequence ID" value="CDP08388"/>
        <property type="gene ID" value="GSCOC_T00027214001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL93"/>
    <dbReference type="OMA" id="HEADGHI"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="14535" checksum="4D87B775B1A3714C" modified="2014-10-01" version="1">MSRSLGIPVKLLHETTGHIVTVELKSGELYRGSMVECEDNWNCQLENITFTAKDGKVSQLEHVFIRGCQVRFMVIPDMLKNAPMFKRLEARIKGKGSTLGIGRGHAVAMRARAQAAGRGAPPGRVVVPPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN35</accession>
    <name>A0A068UN35_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028212001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN35"/>
    <dbReference type="FunCoup" id="A0A068UN35">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN35"/>
    <dbReference type="Gramene" id="CDP09038">
        <property type="protein sequence ID" value="CDP09038"/>
        <property type="gene ID" value="GSCOC_T00028212001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN35"/>
    <dbReference type="OMA" id="EISMNQD"/>
    <dbReference type="OrthoDB" id="1707227at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045884">
        <property type="entry name" value="At5g59350-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34054">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34054:SF16">
        <property type="entry name" value="MEMBRANE LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="316" mass="35288" checksum="83BAF7A73C6341CE" modified="2014-10-01" version="1">MGSFSGLGIGLSFVFGCIFLGLVAELYYLLWWKKRINNREIEDHFTNYAAEISYLFCWKKSNSTDSRRNDTQELAASVINSEVSGHENDLELGGNGKDGSMQFKGFGEESVESELMRLHNLCGPPRFLFTIKEETKEDLESDDGKSRGDRSRKGSRTRSLSDIIIAVDTPFRTPLPSPPLRTPSLDSYSNIHGFNPLFESITEAELNKLRSSPPPKFKFLRDAEEKLIRRLVEEAERMALKNGGCVRDSVIQPSPNGTVITEEVDGSYVAIIGKDNERELQQQQQPSLCHSTPSQVLPLASSPSTFRLADAKSGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN47</accession>
    <name>A0A068UN47_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00030103001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN47"/>
    <dbReference type="STRING" id="49390.A0A068UN47"/>
    <dbReference type="Gramene" id="CDP09682">
        <property type="protein sequence ID" value="CDP09682"/>
        <property type="gene ID" value="GSCOC_T00030103001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN47"/>
    <dbReference type="OMA" id="AENIHEC"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN47"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044653">
        <property type="entry name" value="AZF1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45988">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45988:SF18">
        <property type="entry name" value="C2H2-TYPE ZINC FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="789" mass="87351" checksum="F2993F203C575722" modified="2014-10-01" version="1">MEENKNSNLGKEKQSRLVEEEKNHHESKTNPVSMDGKLLVKLKFPKGAEETEEGAEVVVSPVKKSHFCHECNKGFSSGKALGGHMSSAHVQARENLKKLKFNKSVKFKRDGSSSDAAARETICSICGKDFPSRKSLFGHMRCHPDREWRGMEPPKEQGKIPREHPQSLSILDDDDDEEEEAEEEESLETDNQADYHVHVAADNVAISTVAAEVVDLTRSLSSWSVKGKRGRECPRVLLDSYPYCEEEEQKIQDAVDQLISLAYKQNKHDGSSTRRGQIKEGRNSASGLKKKRVDDPMELEKQNHCFYDDCKKGNVGVKNKRRGPKTTPKNSETEVELTPLDQKLDGEESTPEKFRCSTCDKTFSSHQALGGHRSSHNKFKATVQNTADGSSPFPFGHENRANPVSQTAVENDEIKGVEASKFAENIHECTLCKKTFPSGQALGGHKRCHWQGLSSQVASPEAEEPRPLVRKGLQFDLNEPAEEEDANASDLGNSIAEVVDLTRSMSSWSVKGKRGGECPRVLLDTYSEEEEQKILDAVDQLISLAHKQIIHDGSSTRRGQIKEARNGASGLKKKRVDDQVHPARVRRDYPVKKRQFSEIATDSEETLDGLLDKGKRKDPMKPESGVEISPSSQSRHTVIEKFRCSTCDKTFSSHQALGGHRSSHNKFKATVQNTANGSSPFPSGHENRAKPVSQTAAENDEIKGVEASKFAENIHECTLCKKTFPSGQALGGHKRCHWQGLSSQIASPEAEEPRPLVRKGLQFDLNEPAEEENANTSDLGNSSGDASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNC2</accession>
    <name>A0A068UNC2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030147001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNC2"/>
    <dbReference type="FunCoup" id="A0A068UNC2">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNC2"/>
    <dbReference type="Gramene" id="CDP09709">
        <property type="protein sequence ID" value="CDP09709"/>
        <property type="gene ID" value="GSCOC_T00030147001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNC2"/>
    <dbReference type="OMA" id="MQNLEIG"/>
    <dbReference type="PhylomeDB" id="A0A068UNC2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128:SF24">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128">
        <property type="entry name" value="HOMEOBOX PROTEIN WARIAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="442" mass="48703" checksum="0EA1A0B1B76F961E" modified="2014-10-01" version="1">MEKRLSEAAQSGEISELYELLRLDPTILDKYDEPSFVDTPAHIAAAAGSSHFAIEVLSLKPSFGSKLNPDGYSPLDLALQSEQYPTVKRLVKYDPELIRVKGRERLTPLHYVAQVGDADLLAYFLLLCPKSIQDLTIRGETAVHIAVRYIKVRALRVLLGWLEIAENEQILNWKDENGDTALHIAASTNNFEARDVVRLVISEVKRLKTINAKNLEGLTCLDTFLGLAIRGDERIAKALRDAGAKRSSSLRPSDNLADILSRNPGRMLDFYAALNDVSSETRNALLVVAVLFVTATYSAVLKPPGGISSAGDTILSFQNPCNISSSSSFAGNNTTIYTSNGATGKAQMDGELFPSFITLNTALFVISLRVIFLLLPRPLSLYMGTFGVCLLANYLLSVAIISPERAFSQVFANVFMILILHMISMLFENQDLNPLRRPDLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPD4</accession>
    <name>A0A068UPD4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030952001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPD4"/>
    <dbReference type="FunCoup" id="A0A068UPD4">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPD4"/>
    <dbReference type="Gramene" id="CDP10276">
        <property type="protein sequence ID" value="CDP10276"/>
        <property type="gene ID" value="GSCOC_T00030952001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPD4"/>
    <dbReference type="OMA" id="CDLDNMR"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPD4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="215" mass="23930" checksum="B7E7DB4BD9253378" modified="2014-10-01" version="1">MDSSDEEGSEEYLFKIVIIGDSAVGKSNLLSRYARNEFNPHSKATIGVEFQTQSIEIDGKEVKAQIWDTAGQERFRAVTSAYYRGAFGALLVYDITRKDTFESVRKWLDELNAHSDSTVAKMLVGNKCDLESMRQVSVEDGKSLAEAEGFFFIETSALDSTNVKQAFEIVIREIYSNVSRKVLNPDMSKTELSVNRVSLVDDGAKGWGNYTCCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQ21</accession>
    <name>A0A068UQ21_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031137001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQ21"/>
    <dbReference type="STRING" id="49390.A0A068UQ21"/>
    <dbReference type="Gramene" id="CDP10417">
        <property type="protein sequence ID" value="CDP10417"/>
        <property type="gene ID" value="GSCOC_T00031137001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQ21"/>
    <dbReference type="OrthoDB" id="1837350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQ21"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373:SF14">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373">
        <property type="entry name" value="OS07G0479600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="150" mass="16414" checksum="7D8D3C58AB9F5296" modified="2014-10-01" version="1">MGCSCLPNLDNTVVFNLFFLFFTFCSLSSVVVVSKVATGLCKTLKLSARGCFGCCTKSQPIIAVDEPSKGLRIQGRLVKKPSISEDFWSTSTCDLENSMVQSQRSMSSISISNQSLSQQGGTGNSINHSEFVNHGKYTLQSPLYCWLSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URN6</accession>
    <name>A0A068URN6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">1,3-beta-glucan synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00033125001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068URN6">
        <property type="interactions" value="1273"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URN6"/>
    <dbReference type="Gramene" id="CDP11096">
        <property type="protein sequence ID" value="CDP11096"/>
        <property type="gene ID" value="GSCOC_T00033125001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URN6"/>
    <dbReference type="OMA" id="LAKFKTW"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058851">
        <property type="entry name" value="CALS1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF47">
        <property type="entry name" value="CALLOSE SYNTHASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25968">
        <property type="entry name" value="CALS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1481"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1630"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1654"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1730"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1760"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1791"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1820"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1862"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="15">
        <location>
            <begin position="345"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1916" mass="220284" checksum="58A051815811643B" modified="2014-10-01" version="1">MSRAEELWERLVRAALRRQRSGADAYGRVDGGIAANVPSSLANNRDIDDILRAADEIQDQDPNVARILCEHAYSLAQNLDPNSEGRGVLQFKTGLMSVIKQKLAKREGGTIDRSQDIARLQEFYKQYREKNNVDKLREEEMQLRDTGVFSGKLGELERKTVKRKRVFATLKVLGNVLAQLTKEVSPEEAERLIPEELKRVIESDAAMTEDLVAYNIIPLDAPARTNAIGFFPEVRAASSAIKYFRGLPKLPADFSIPPTRSADMFDFLHYTFGFQKDNVSSQREHVVHLLANEQSRLRILEEPEPILDEAAVQNVFMKSLENYINWSRYLAILPVWNNSEDVSKEKKLLFISLYFLIWGEASNVRFLPECLCYIFHHMGRELEEILRQQVLQPANSCVLENGVSFLDRVIRPLYDVVAAEAANNDNGRAAHSAWRNYDDFNEYFWSLRCFELSWPWRTSASFFVKPTPRSMNVLKSGGSKHRGKTSFVEHRTFLHLYHSFHRLWIFLIMMFQGLAVIGFNDGQFDSKTIRELLSLGPTYVVMKFIQSVLDILMMYGAYSTSRRVAVSRIFLRFICFSLASVFICFLYVKALQEENKPNSESILFKIYVVILAIYAGLHVSLSIVMRIPACHHLGSLFDNWPLVRFIKWMHQEHYYVGRGMYERTSDFLKYMIFWLLVLGCKFSFAYFIQIKPLVKPTRQVIDMEITNYSWHDFVSKHNHNALTVASLWAPVFAMYLLDIYIFYTVISAVLGFLLGARDRLGEIRSLDAVHKLFEGFPEAFMDTLHVPLPNRASLRSSGQALEKNKEDAAHFAPFWNEIIKNLREEDYITNLEMELLQMPQTSGNIPLVQWPLFLLASKIFLAKDIAIESRDSHEELWDRISRDDYMKYAVQECYYTIEVILTAILDDEGNDEGRKWVERIYEDIRGSIAIKNIHNDFQLEKLALVIQKVTALMGVLREDHTPELESGAIKAVQDLYDVMHYDVLNINMRDNYETWNVLSRARNQGRLFQKLKWPRDVKLRLQIRRLYSLLTIKDSAANIPENLEARRRLQFFTNSLFMEMPVAKPVREMLSFSVFTPYYSEIVLYSMSDLLKKNEDGISTLFYLQKIYPDEWKNFLARIGRDENASESELNDNTNDILELRFWASYRGQTLARTVRGMMYYRKALMLQAYLERMMAGDLESAISKYEVMDIQGFELSPEARAQADLKFTYVVTCQIYGKQKEERKPEAADIALLMQRNEALRVAFIDVVETLKDGKVHTEYYSKLVKADINGKDQEIYSVKLPGNPKLGEGKPENQNHAVIFTRGNAMQTIDMNQDNYFEEALKMRNLLEEFHRDHGIHAPTILGVREHVFTGSVSSLASFMSNQETSFVTLGQRVLAKPLKVRMHYGHPDVFDRVFHITRGGISKASRVINISEDIYAGFNSTLRQGNITHHEYIQVGKGRDVGLNQIALFEGKVAGGNGEQVLSRDVYRLGQLFDFFRMISFFFTTVGYYFCTMLTVLTVYIFLYGRAYLALSGVGETIQIRARILNNTALSAALNAQFLFQIGVFTAVPMVLGFILEQGFLRALVSFVTMQFQLCTVFFTFSLGTRTHYFGRTILHGGARYQATGRGFVVRHIKFSENYRLYSRSHFVKGMEVVLLLVVYLAYGYNEGGAIGYILLTVSSWFLAISWLFAPYLFNPSGFEWQKTVEDFRDWTNWLLYRGGIGVKGEESWEAWWDEELAHIRTLRGRLLESILSLRFFVFQFGIVYKLHIQGSNTSLTVYGFSWAVFALLIILFKVFTFSQKISVNFQLVLRFIQGVSFLLALAGLAAAVVFTKLSVSDIFACILAFLPTGWGILCIAVAWKPVVKKMGLWKSVRSIGRLYDAGMGMLIFIPIALFSWFPFISTFQTRLMFNQAFSRGLEISLILAGNNPNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URT5</accession>
    <name>A0A068URT5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00031015001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URT5"/>
    <dbReference type="Gramene" id="CDP10323">
        <property type="protein sequence ID" value="CDP10323"/>
        <property type="gene ID" value="GSCOC_T00031015001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URT5"/>
    <dbReference type="OMA" id="MIVICEQ"/>
    <dbReference type="OrthoDB" id="1478287at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URT5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="11">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="12">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="13">
        <location>
            <begin position="370"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP10323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="686" mass="78943" checksum="A7C6F808B25FA6B0" modified="2014-10-01" version="1">MGGIGKTTLARQMFDHPDTDFQFHCRAWVRVSQVYQLRNLLLDLLRSVTKPSDNVHEKTNEDLAQDLYQSLKGRKYLVVMDDVWSNEAWDCIQMCLPDDNNGSRVVVTSRFMELATYVSPKSLPHCMSLLDTKQSWELLEKLVFGLESCPLELVDLGKQIARKCHGLPLAIVVIAGTLSRTVMTSDCWKDVAASVSSVVFTNPEQCLDILALSYNYLPQQLKACFLYMGAFPEDYEIEVRKLFRLWIAEGFLEASSSSNLEDVAEAYLEDLIGRSLVLVGKRNVVGKIKSCRLHDLLRELCLREAQKENIMTVIKQEDQSFPAKDNQRHLILHLNSDADVHLAPPYRSLQSFLCFTLGSGFVPDIFFSYLIFQSLRVLDMFFLQFDSFPAQIVNLEYLTYLALNVTYKLPTALARLKNLQTLVINGPWPIRDDADLPTLIVRYWSMPNLRHLHTTMVAFLSYITDAASNIYRKPLPLGYLKTLSTVQFLCCRRDAFANMPYLAELGLCETKEDYYRDRSCECLKDLAYLHKLEALNCSFYREIREARTISWDAFPSNLRKLTLSASNLPWEDMTNVAKLPNLEVLKLKNYAFRGSTWKLTDEVFRCLKQLLIEKTDIVQWEAEDDHFPCLQFLILRSCEFLAELPYVLGEIPTLERIELHYCNESAELSAQEFKDLIEDLAVIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URW0</accession>
    <name>A0A068URW0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00033373001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="8">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URW0"/>
    <dbReference type="FunCoup" id="A0A068URW0">
        <property type="interactions" value="1761"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URW0"/>
    <dbReference type="Gramene" id="CDP11250">
        <property type="protein sequence ID" value="CDP11250"/>
        <property type="gene ID" value="GSCOC_T00033373001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URW0"/>
    <dbReference type="OMA" id="HEWVEMV"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URW0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000011">
        <property type="entry name" value="Glycine cleavage system H protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="154" mass="16871" checksum="EB3FCC8F265C1813" modified="2014-10-01" version="1">MATKLWASKAASYLRISVFHRGFATVVKDLKYADSHEWVKVDGNSATVGITDHAQDHLGDVVYVELPEVGKEVKQGDSFGAVESVKATSDVYSPVSGKVVDVNEKLGDSPGLVNGSPYEDGWIMKVEISNKDELNSLLDSEQYTKHCEAEDQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UST2</accession>
    <name>A0A068UST2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00033438001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UST2"/>
    <dbReference type="STRING" id="49390.A0A068UST2"/>
    <dbReference type="Gramene" id="CDP11289">
        <property type="protein sequence ID" value="CDP11289"/>
        <property type="gene ID" value="GSCOC_T00033438001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UST2"/>
    <dbReference type="PhylomeDB" id="A0A068UST2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="72" mass="7616" checksum="1B8FA1A8D6B241FD" modified="2014-10-01" version="1">METGKVVVERVGGKSTATHCYSKYPLKFIIRSKVGPSQTDAVWIYTITYGGGIVSGDSTKCDISVGDGAPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USZ2</accession>
    <name>A0A068USZ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00031508001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USZ2"/>
    <dbReference type="Gramene" id="CDP10708">
        <property type="protein sequence ID" value="CDP10708"/>
        <property type="gene ID" value="GSCOC_T00031508001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USZ2"/>
    <dbReference type="OMA" id="VMHESTT"/>
    <dbReference type="PhylomeDB" id="A0A068USZ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40392" checksum="176450C85EBEB4FA" modified="2014-10-01" version="1">MSGSRVLETQTPPLETENEAGPGGWRSASFMLAGGSLERFAYYGVESNRISYLTGPIGESVATAAANVNTWIGVVSLVPVLGAYLADSFLGRHRSIIFTSLLYILGLGLLSLSAIIIPTSTSSSTYQGMNKKSGPKTGLQVLFFVSLYLVALAQGYKPWVQAFGADQFDGKHPEQSKAKSSFFNWWLCGICIGSTAAHLILHYIQDNINWALGFGIPCLAMILGLTLFLLGSRIYFFPVKRASSSQEEYQEDLLLNARQRSQDYRFLENVSPAADDYSTVSDKTEVPKNVLRLFPIWITCLTYTVAYAQAATLFTKQATALDKSIGLSFNIPAATLRTFVPLTIMLCIPIYDRIFIPVARTITKNPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT97</accession>
    <name>A0A068UT97_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00033837001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UT97"/>
    <dbReference type="FunCoup" id="A0A068UT97">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UT97"/>
    <dbReference type="Gramene" id="CDP11537">
        <property type="protein sequence ID" value="CDP11537"/>
        <property type="gene ID" value="GSCOC_T00033837001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT97"/>
    <dbReference type="OMA" id="YFRITNG"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT97"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000007">
        <property type="entry name" value="Chlorophyll a-b binding protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="3 13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11 13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5 13" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>5</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="289" mass="30999" checksum="6283C9809649320F" modified="2014-10-01" version="1">MASLAASTAAASLGVSEMLGNPLNFTSSSRCAPSPSNTASFKTVALFSKKKAAAKPKPAADSSLDDELAKWYGPDRRIFLPEGLLDRSEIPEYLTGEVPGDYGYDPFGLSKKPEDFAKYQAYELIHGRWAMLGAAGFVIPEALNKFGANCGPEAVWFKTGALLLDGNTLNYFGKNIPINLAFAVIFEVVLVGGAEYYRITNALDLEDRLHPGGPFDPLGLAKDPDQFALLKVKEIKNGRLAMFAMLGFFIQAYVTGQGPVENLAAHLSDPFGNNLLTVIAGTAERAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTX4</accession>
    <name>A0A068UTX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00033094001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTX4"/>
    <dbReference type="FunCoup" id="A0A068UTX4">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTX4"/>
    <dbReference type="Gramene" id="CDP11078">
        <property type="protein sequence ID" value="CDP11078"/>
        <property type="gene ID" value="GSCOC_T00033094001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTX4"/>
    <dbReference type="OMA" id="CKEKATH"/>
    <dbReference type="OrthoDB" id="1897584at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35295">
        <property type="entry name" value="DNA LIGASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35295:SF1">
        <property type="entry name" value="DNA LIGASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19528" checksum="466332FBE088B227" modified="2014-10-01" version="1">MMALQQIRKKAQKDGQKKNEETISNVASEIKSNLDELRTKLEKDRQAFAKALSKSSKDCENLLKNESTKFQAVYENFCKEKTTHMQGLKDAISKYEEEKEKLFMRYEQLRKKEKSMIAELEKACASRITDLEESLKKKKQDDKTFSILRKTLGSFLDNASDEDFPPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUE9</accession>
    <name>A0A068UUE9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00035422001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the 7-subunit TFIIH core complex composed of XPB, XPD, TFB1/GTF2H1, GTF2H2/P44, TFB4/GTF2H3, TFB2/GTF2H4 and TFB5/GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CYCH1/cyclin H1, CDKD and MAT1/At4g30820 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUE9"/>
    <dbReference type="FunCoup" id="A0A068UUE9">
        <property type="interactions" value="3077"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUE9"/>
    <dbReference type="Gramene" id="CDP12051">
        <property type="protein sequence ID" value="CDP12051"/>
        <property type="gene ID" value="GSCOC_T00035422001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUE9"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUE9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="278"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="495"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="753" mass="85192" checksum="5A8C5A5E2E20FF32" modified="2014-10-01" version="1">MKKIFAISGDKVRPSKKIKFSNKEHRSTAVEDYDPSYAEDIDDDYRDGEGKKWDFTELELKPDHANRPLWACADGRIFLETFSPLYKQAYDFLIAIAEPVCRPESMHEYNLTPHSLYAAVSVGLETETIVSVLSKLSKTKLPKEMIKFIHDSTANYGKVLKRLLKDEVIGRARISTEGLHGSDGFTVSKSMGEIEGRHDELLNEAELAAAAEEKETHSFEIDPAQVENVKQRCLPNALNYPMLEEYDFRNDTVNPDLDMELKPQAQPRPYQEKSLSKMFGNGRARSGIIVLPCGAGKSLVGVSAASRIKKSCLCLATNAVSVDQWAFQFKLWSTIRDEQICRFTSDSKERFRGNAGVVVTTYNMVAFGGKRSEESEKIIEEIRNREWGLLLMDEVHVVPAHMFRKVISLTKSHCKLGLTATLVREDERITDLNFLIGPKLYEANWLDLVKGGFIANVQCAEVWCPMTKEFFAEYLKKENSKKKQALYVMNPNKFRACEFLIRFHEQQRGDKIIVFADNLFALTEYAMKLRKPMIYGATSHVERTKILEAFKTSRDVNTIFLSKVGDNSIDIPEANVIIQISSHAGSRRQEAQRLGRILRAKGRLQDRMAGGKEEYNAFFYSLVSTDTQEMYYSTKRQQFLIDQGYSFKVITSLPPPDSGPELSYHRLDEQLALLGKVLSAGDDAVGLEQLEEDADGMALQKARRSAGSMSAMSGASGMVYMEYNTGQKRPGHGMKSKPKDPAKRHHLFKKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUT0</accession>
    <name>A0A068UUT0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00035727001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUT0"/>
    <dbReference type="STRING" id="49390.A0A068UUT0"/>
    <dbReference type="Gramene" id="CDP12280">
        <property type="protein sequence ID" value="CDP12280"/>
        <property type="gene ID" value="GSCOC_T00035727001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUT0"/>
    <dbReference type="OMA" id="LASCIQI"/>
    <dbReference type="OrthoDB" id="1877784at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUT0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF93">
        <property type="entry name" value="ALPHA-HUMULENE_(-)-(E)-BETA-CARYOPHYLLENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="109" mass="12420" checksum="5A99842A862FBC22" modified="2014-10-01" version="1">MKMLARAYFVEAKWLHQGYMPTLEENMKNAVPSSGYPTLTIISFLGMGDIVKKEAFDWALKVPEIVRAASIIARLRNDIVGYKFEQKREHIAKLMPYDATKHNGATSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVP1</accession>
    <name>A0A068UVP1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA (cytosine-5-)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00035865001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739148">
        <property type="protein sequence ID" value="CDP12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVP1"/>
    <dbReference type="STRING" id="49390.A0A068UVP1"/>
    <dbReference type="Gramene" id="CDP12367">
        <property type="protein sequence ID" value="CDP12367"/>
        <property type="gene ID" value="GSCOC_T00035865001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVP1"/>
    <dbReference type="OMA" id="YPNEECC"/>
    <dbReference type="PhylomeDB" id="A0A068UVP1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF25">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13034" checksum="305813CDF50C1951" modified="2014-10-01" version="1">MSDVRYSLFYKKWNLIWVGMNKVASLESHEIEMLKGFPPNHTNGGGISRTKQYTILGNAFPLIISKQIFFAYHLSVLKSMFLDKISVLSVKSRNFTWLYNPYVSSLTLDSCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVZ3</accession>
    <name>A0A068UVZ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00036016001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="19"/>
    <dbReference type="EMBL" id="HG739149">
        <property type="protein sequence ID" value="CDP12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVZ3"/>
    <dbReference type="Gramene" id="CDP12449">
        <property type="protein sequence ID" value="CDP12449"/>
        <property type="gene ID" value="GSCOC_T00036016001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVZ3"/>
    <dbReference type="OMA" id="HADISSH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVZ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.30:FF:000003">
        <property type="entry name" value="Os04g0303100 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000248">
        <property type="entry name" value="S-receptor-like kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF30">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="22">
        <location>
            <begin position="70"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="23">
        <location>
            <begin position="381"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="562"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="879" mass="97996" checksum="9FDDD563C5AC4732" modified="2014-10-01" version="1">MSILTWLNFYSKPRQTYFHIIFLQVYKTRTNSLSQNMDVKQRLLYAIFLSSLLLSSMSSLTAQKENYNSTAYLPASWINQASESLMINSTGGNIVIPILLRGSDGPRYVCGFYCNMEGNQCVFGVLISQSRRSNDEYLQSPELVWSANRNNPVHSNATLQLRQDGDLVLANSDGTLIWSSHTRGKLVSGLKLTKMGNLVLFGPKNESIWESFDHPTDSLLLGQKLGPGQKLRASDSATNWSQGRLSLAVGSNGLSAYIESDPPQRYYVSGTNSYPFYEFRNGSLNDLTIPPASGAQFIKFEPDGHLKVYQWRDMRFVEVIDLLDPYVGDCGYPMVCGNYGVCSKGQCGCIETTNDQEKSYFSQINFRQPNLGCSRVTPIFCDDSRDHTLLELTNTSYFAVDSSLDKANMGMEDCKSKCLSNCSCKAALFYYTDQRDSVLESNGNCLLLNEVFSIINNEDNIRPPYNTTVLVKVQDVYVHSSSSSSSSSSSSSSSSSSSSDIKQTILGCTFAVLACVVSLICYCLILLRRILEDSEETEGHFLNQLPGMPTRYSYEKLKSMTEDFSKKLGQGGFGSVYEGVLSDGTKIAVKCLDGSGQVKDSFLAEVQIIGSIHHVNLVKLIGFCFHKLHQLLVYEYMANGSLDKWICGGKNSQSLPWNARRRIITDIAKGLAYLHEDCSHKIIHFDIKPQNILLDQNFNAKVADFGLSKLVEKDQSRVITKMRGTPGYLAPEWLSSVITEKVDVYSFGIVMLEIICGRKNVDWSKIEEDKHLLSIFKRKAEEERLQDMVDKNNLDMLIHVQEAVEMMEIAAWCLQSDFTKRPSMSLLVKVLNGLVAPETNLDYDFTKPSVVETGAAGHLVIEAENIASQLLPSALSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWU9</accession>
    <name>A0A068UWU9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LOB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037395001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739154">
        <property type="protein sequence ID" value="CDP12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWU9"/>
    <dbReference type="FunCoup" id="A0A068UWU9">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWU9"/>
    <dbReference type="Gramene" id="CDP12757">
        <property type="protein sequence ID" value="CDP12757"/>
        <property type="gene ID" value="GSCOC_T00037395001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWU9"/>
    <dbReference type="OMA" id="ACNEMSS"/>
    <dbReference type="OrthoDB" id="1926568at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWU9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF91">
        <property type="entry name" value="PROTEIN LATERAL ORGAN BOUNDARIES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="193" mass="21475" checksum="5D01E406A13BA2C8" modified="2014-10-01" version="1">MASSSSYNSPCAACKFLRRKCMPGCIFAPYFPPEEPQKFANVHKIFGASNVSKLLNELLPHQREDAVNSLAYEAEARVKDPVYGCVGAISFLQRQVERLQKELDAANADLIRYACNDHIQPELSAPHGAMHQVHQPMTPRQRPVEYNNTRRMGNEGGGFYQTPNFQYPYHLPWNDNDIHRYGGGGGGGGGGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX96</accession>
    <name>A0A068UX96_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00037625001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX96"/>
    <dbReference type="STRING" id="49390.A0A068UX96"/>
    <dbReference type="Gramene" id="CDP12927">
        <property type="protein sequence ID" value="CDP12927"/>
        <property type="gene ID" value="GSCOC_T00037625001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX96"/>
    <dbReference type="OMA" id="RILINCW"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX96"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47943:SF2">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47943">
        <property type="entry name" value="CYTOCHROME P450 93A3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16730" checksum="9D3E620DB03C8B93" modified="2014-10-01" version="1">MLAGALDTSATVVEWTLAVLQKSQRVLKKVQQELEEVVGLDRMVEESDLEYLNYLNMVVKEALRLHPAAPLLVPHAAMENCSVDGFHIPKNSRVIINVWTIGRDPNAWSDPEKFIPERFIRSNIDVKGHDFQLLPFGSGRRGCPGVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXS0</accession>
    <name>A0A068UXS0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00037819001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXS0"/>
    <dbReference type="STRING" id="49390.A0A068UXS0"/>
    <dbReference type="Gramene" id="CDP13059">
        <property type="protein sequence ID" value="CDP13059"/>
        <property type="gene ID" value="GSCOC_T00037819001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXS0"/>
    <dbReference type="OrthoDB" id="25592at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXS0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="21728" checksum="D830C5D2555BC2F4" modified="2014-10-01" version="1">MSSDVISSFIENSFLSGHAANLSLKGSPYWMAPELLQSVMQQDSNSDLALAIDIWSLGCTIIEMLNGKPPWSEYEGAAAMFRVLKETPPIPENLSAEGKDFLRCCFRRNPAERASASTLLEHRFVTTSHPPDILSCSLSLSGMKLRDDANSQRERSNSKLGQVPAYSDMHIAKGKLTDNYIHGSLAPVRLANDVATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY81</accession>
    <name>A0A068UY81_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase D</fullName>
            <ecNumber evidence="10">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00038475001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phospholipase D family. C2-PLD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="10"/>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY81"/>
    <dbReference type="STRING" id="49390.A0A068UY81"/>
    <dbReference type="Gramene" id="CDP13510">
        <property type="protein sequence ID" value="CDP13510"/>
        <property type="gene ID" value="GSCOC_T00038475001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY81"/>
    <dbReference type="OMA" id="MEMMYLD"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY81"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04015">
        <property type="entry name" value="C2_plant_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000027">
        <property type="entry name" value="Phospholipase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000025">
        <property type="entry name" value="Phospholipase D delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024632">
        <property type="entry name" value="PLipase_D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011402">
        <property type="entry name" value="PLipase_D_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF169">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12357">
        <property type="entry name" value="PLD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036470">
        <property type="entry name" value="PLD_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="825" mass="93878" checksum="580CD61C17BF64C3" modified="2014-10-01" version="1">MASKLLHGTLQATIFEIDRLQTGWGFNFCGKTGGPAKMARRFFARLKRAVLCRPEIVGSRLYATIDLERARVGRTRMIEKQLSNPRWYEGFRIYCAHMVSNVIFTVKDDNAVGATLIGRAYLPVEEIISGFVVDRWLQILDEDGIPIQGGPKIHVKLQFFSVNHDPNWSQGIGGSLAFKGVPRTFFKERQGCHVTLYQDAHMPDTAFSNCLESKLRYEPQRCWEDIFDAINNAKHLIYITGWSVYTQITLIRDPYRPKPGGDITLGELLKKKANEGVRVLLLVWDDRTSVETLKRDGMMATHDQETGDFFRDTNVHCVLCPRNPDDGNSIIQGFEVSTMFTHHQKTVIVDSEIPESRGEPKRRIVSFLGGIDLCDGRYDTIAHPLFSSLNTAHHDDFHQPNFPDSNIRKGGPREPWHDVHCKLEGPAAWDVLCNFQQRWQRQVGNNYLFSINELDRFAIPPSPVTKSEDHETWNVQVFRSIDGGAAYGFPENPAEAAQVGLVSGKDHIIDRSIQDAYINAIRRAKNFIYIENQYFLGSSYGWEGNDIQVPDINALHLIPKELSLKIVSKIEAGEKFTVYVVIPMWPEGIPESASVQAILDWQRRTMEMMYKDIARALQAKGERDDVDLRDYLTFFCLGNRESREVGEYAPPETPNPGTDYARAQKSRRFMIYVHAKTMIVDDEYIIVGSANINQRSMDGARDTEIAMGGYQPHHLSNAEPAQGSIFRFRMALWLEHLDVLDYVFYHPGTLECVRQVNLLAERNWELYSSDTFPDNENLSAQLLRYPVNVSRDGIITALPGLDFFPDTKARVLGTKSDYLPPILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ95</accession>
    <name>A0A068UZ95_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038628001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ95"/>
    <dbReference type="FunCoup" id="A0A068UZ95">
        <property type="interactions" value="2910"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13622">
        <property type="protein sequence ID" value="CDP13622"/>
        <property type="gene ID" value="GSCOC_T00038628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ95"/>
    <dbReference type="OMA" id="IYAMYCV"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ95"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032843">
        <property type="entry name" value="Jiv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45270:SF1">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45270">
        <property type="entry name" value="OS03G0832900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14901">
        <property type="entry name" value="Jiv90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="278"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="540" mass="61428" checksum="A40F08E34FFA5226" modified="2014-10-01" version="1">MVAIQENLLLCCENNSRLLPRQDWDIYREALANGLLCVCKAGETDVAFVDSMEGLWSQGISLYFIGLGSAALLVIMWSCFLSLTSLSCLVYVLLSMGAAGIAVQYLGYTPGLFIVGLFAILILWMYANFWITGTLFIVGGYLFSLNHARLVVLMAMIYAMYCVKVRVGWFGVFLSINLAFLSNDVLNYVLQCCDNLSESVPIEEQTKSESFTEDGFSTECEYSVPADEPEKVQSCKSSSKPAVASSLVNKQKESTAKQVIREDENSIIEMKRILGSNNHYEALEFPRNKKVDSILLRKEYRKKAMLVHPDKNMGSTLASESFKKLQCAYEVLSDAVKKRDYDEQLKKEESKSVIQRSSSTSRQQDSSDYCLEESRRIQCTKCGNSHIWVCTNRTKAKARWCQDCCQYHQAKDGDGWVEYKGSLIFDQPRKVEIPRAFVCAESKIFDVSEWAICQGMACRPNTHRPSFHVNMVGLDKSSQRSNSSRYPWDLDAEVMDEDEDFELWLQQALASGLFCETSKRRKSWSPFKLHHRKKSWRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0G9</accession>
    <name>A0A068V0G9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00038291001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0G9"/>
    <dbReference type="FunCoup" id="A0A068V0G9">
        <property type="interactions" value="1771"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0G9"/>
    <dbReference type="Gramene" id="CDP13378">
        <property type="protein sequence ID" value="CDP13378"/>
        <property type="gene ID" value="GSCOC_T00038291001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0G9"/>
    <dbReference type="OMA" id="DYNDMAR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0G9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="257" mass="27511" checksum="2E943F826F24B5BA" modified="2014-10-01" version="1">MAVPFATLSNVGSVSAPIRTLCPLKISRISIPSCCLPKRIPATVSTASHSTFLSGSSRLTSSSNSSNPLLLSKRGAFLLSEASLQSKVTHKVYLDISIGNPVGKLAGRIVIGLYGDDVPQTAENFRALCTGEKGFGYKGSSFHRVIKDFMIQGGDFDKGNGTGGKSIYGRTFKDENFKLSHTGPGVVSMANAGPNTNGSQFFICTVKTPWLDQRHVVFGQVLEGMDIVRLIESQETDRGDRPRLRVVVSDCGELPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1D2</accession>
    <name>A0A068V1D2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH200=94 genomic scaffold, scaffold_88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00041145001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739172">
        <property type="protein sequence ID" value="CDP14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1D2"/>
    <dbReference type="FunCoup" id="A0A068V1D2">
        <property type="interactions" value="2113"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1D2"/>
    <dbReference type="Gramene" id="CDP14595">
        <property type="protein sequence ID" value="CDP14595"/>
        <property type="gene ID" value="GSCOC_T00041145001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1D2"/>
    <dbReference type="OMA" id="THTQREP"/>
    <dbReference type="OrthoDB" id="1875375at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1D2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="168" mass="19207" checksum="E2D0012C3080B8E4" modified="2014-10-01" version="1">MLQRFIFLAPSRRSTIIKPSYRNPNRLLRYKLSPQISFARVYSDGIIPNSQSSLLCVLSPPSKMVNVPKTKKTYCKSKECKKHTLHKVTQYKKGKDSLAAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKIVLRLQCQGCKHVSQHPIKRCKHFEIGGDKKGKGTSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1I7</accession>
    <name>A0A068V1I7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable alanine--tRNA ligase, chloroplastic</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00041035001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Plastid</location>
            <location evidence="15">Chloroplast</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1I7"/>
    <dbReference type="FunCoup" id="A0A068V1I7">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1I7"/>
    <dbReference type="Gramene" id="CDP14521">
        <property type="protein sequence ID" value="CDP14521"/>
        <property type="gene ID" value="GSCOC_T00041035001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1I7"/>
    <dbReference type="OMA" id="GFDMEME"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1I7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.54.20:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000007">
        <property type="entry name" value="Probable alanine--tRNA ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.54.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03134">
        <property type="entry name" value="Ala_tRNA_synth_plantC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027522">
        <property type="entry name" value="Ala_tRNA_synth_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 15" id="KW-0934">Plastid</keyword>
    <keyword evidence="11 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="92"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP14521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="991" mass="108576" checksum="FD50EF5FA68D43CA" modified="2014-10-01" version="1">MGSLKVPCSFGGKAALLVPFPASRFRVPQSHCYRPSSTGWRSFPGFVLQSLELVYPNSSCSVHSGRVHLTARASVQPATKKLVGDQVKDLPNSGDSIRQRFLEFYAARGHKILPSASLVPDDPTVLLTIAGMLQFKPIFLGKVPREVPRATTSQRCIRTNDIENVGQTSRHHTFFEMLGNFSFGDYFKKEAIKWAWELSTIEFGLPADRLWISIYEDDDEAFAIWQDEVGVPAKRIKRLGEDDNFWSSGVTGPCGPCSEIYYDFHPERGESNVDLGDDTRFIEFYNLVFMQYNKKDDGSLESLKQRNIDTGLGLERVARILQKVPNNYETDLIFPIIEKASELANVSYAVADDCTQRYLKTIGDHMRAIVYLISDGVIPSNIGRGYVVRRLIRRAVRMGRLLGIKGDGLGDIEGAFLPVLAERVIQLSTHIDSDVKNRAARIFDELKREELRFVQTLERGEKLLEQILAEALLDSEKSGTAPCLSGKDAFLLYDTYGFPVEITKEVADGRGAGIDMNGFDAEMENQKRQSQAAHNVIKLGVENGADLTEKVPDTEFVGYDTLCANAVIEGLLVNGNPVIQVSEGNEVEVLLNRSPFYAESGGQIGDHGILYVSNAGNHQKAAVEINDVQKSLGNIFFHKGTVTQGVIEVGFEVEAAVDAKLRQRAKVHHTATHLLQAALKQVLGEETSQAGSLVAFDRLRFDFNFHRPVTDDELMEIEGLINRWISDSTLLETKVMPLTDAKRAGAIAMFGEKYADQVRVVEVPGVSMELCGGTHVNNTSELRGFRIISEQGIASGIRRIEAVAGDAFIEHILARDNYMKQLCSTLKVKAEDVTTRVEALLEELRAARNEVSAANAKAAIFKASTITCKALSVGTSREIRVLVESMDDVDGDALRSAADYLLDALQDPAAVFLGSRPGEGKVSLIAAFSPGVVELGLQAGKFIGPVAKMCGGGGGGRPNFAQAGGRKPENLLGALEKARQDLIAIISEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V275</accession>
    <name>A0A068V275_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formiminotransferase N-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042138001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V275"/>
    <dbReference type="STRING" id="49390.A0A068V275"/>
    <dbReference type="Gramene" id="CDP14716">
        <property type="protein sequence ID" value="CDP14716"/>
        <property type="gene ID" value="GSCOC_T00042138001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V275"/>
    <dbReference type="OMA" id="WAQPEQV"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V275"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF5">
        <property type="entry name" value="PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="318" mass="35242" checksum="F3ECAC55EA5DF1DE" modified="2014-10-01" version="1">MDSISSQSSKDKKKTVMHSMLLCCKLYISEARNAEALDSIERAAKRDPETVIVNKFEDRDYNRVCYTLVSYVVHDSTGCPIYSPLQQSVVAMAEAAYEAINLEQHLGTHPRLGVMDDILCHPLARASLDEAAWLAQKVAAEIGNRFQVPVYLYGAANPTGKALDTIRRELGYFRPNNGHHWVGWTQPQVLPEKPNEGPEVVTSARGISMIGARPWIAMYNIPVMSTDVSTARRIALMVSARGGGLPTVQTLGLVHGEDSTEIACMLLEPNQIGADRVQNHVEKLAAQEGLDVEQGYFTDIPPQMITERYRKLINAYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4B3</accession>
    <name>A0A068V4B3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00043139001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4B3"/>
    <dbReference type="FunCoup" id="A0A068V4B3">
        <property type="interactions" value="1413"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4B3"/>
    <dbReference type="Gramene" id="CDP15412">
        <property type="protein sequence ID" value="CDP15412"/>
        <property type="gene ID" value="GSCOC_T00043139001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4B3"/>
    <dbReference type="OMA" id="NALVTEW"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4B3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="7">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP15412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="158" mass="17552" checksum="954C3CA0B5D72837" modified="2014-10-01" version="1">MIRRLVPFFAARIRENHLRLLGSSSASSSVLREQPPPPQPSPSQSQSQSIVAVHMTDNCVRRMRELQSQEGKEKMLRLSIEAGGCSGFQYNFSLDDKHNDDDRIFEREGVKLVVDKISLDFVNGATVDFVEELIRSAFQVSSNPSAVGGCSCKSSFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6M9</accession>
    <name>A0A068V6M9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage and polyadenylation specificity factor subunit 3-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00018068001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739204">
        <property type="protein sequence ID" value="CDP16291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6M9"/>
    <dbReference type="FunCoup" id="A0A068V6M9">
        <property type="interactions" value="2278"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6M9"/>
    <dbReference type="Gramene" id="CDP16291">
        <property type="protein sequence ID" value="CDP16291"/>
        <property type="gene ID" value="GSCOC_T00018068001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6M9"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6M9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010197">
        <property type="term" value="P:polar nucleus fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="246"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72917" checksum="42B155664AB00EB3" modified="2014-10-01" version="1">MAIECLVLGAGQEVGKSCVVVTINGKRIMFDCGMHMGYLDDRRYPDFSLIPRNAAEDFTSSLSCIIITHFHLDHIGALPYFTEVCGYKGPIYMTYPTKALAPLMLEDYRKVMVDRRGEEEQFSSKDIVECMKRVTAVDLKQTVQVDKDLQIRAYYAGHVLGAAMFYAKVGDAAMVYTGDYNMTADRHLGAAQIDRLHLDLVITESTYATTLRESKYVREREFLKAVHNCVACGGKVLIPSFALGRAQELCMLLDDYWERMNLKIPIYFSAGLTIQANVYYKTLINWTSQKVKDSYAARNPFNFRNVCKFERSLINAPGPCVLFATPGMISGGFSLEVFKQWAPDEVNLITLPGYCVAGTVGHRLMSAKTPTQVNIDQNTQIDVRCQIRQLSFSPHTDAKGIMDLIKFLSPKHVILVHGEKPKMESLKGKIESDFDMQCHVPANNETVSIPSTHYVKADASSAFLKSTWSPNFKFVTERSSGNLITDDMDMISKPVLRVRDDRVAEGILTTGKHQNPKIVHLKELVHTSGLETHDVQFALCFPVRITKMDEQQQLNPVSQESLPFLHQLFLKLSNNFSEATIQESDQNLQIESFIVSVCSKEKCPHRMNDGPDYTYEAVHFCCTWSGADEKLARNVISFMKNLVLNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7F3</accession>
    <name>A0A068V7F3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase subfamily 4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00016690001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739195">
        <property type="protein sequence ID" value="CDP15823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7F3"/>
    <dbReference type="STRING" id="49390.A0A068V7F3"/>
    <dbReference type="Gramene" id="CDP15823">
        <property type="protein sequence ID" value="CDP15823"/>
        <property type="gene ID" value="GSCOC_T00016690001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7F3"/>
    <dbReference type="OMA" id="HASTLYH"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7F3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46686">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46686:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="296"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP15823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54439" checksum="39961F93E5FF7BDA" modified="2014-10-01" version="1">MGLKHSNRKFHSRPKLSLLKCSTIVAAFLFLASFIYFFSPLADFAKSWSREVHFKGDLREAKFPWNKLCFGQANEKLKLAVFSKSWPIGAAPGGMERHASTLYTALAAKGHEIHIFTAPSDRRAHEDIHQGNLHVYFASNDHGSVNCSLAFDIFNRENKMNEFDYVHTESVSLPYWRARVVPKVAVTWHGVWYEIMHSKLFQELLSNPKEQLPGPMTELQEAMPRLLNEIRFFSIYKQHICISDSAGEVLVNIYQLPQRNVHVILNGVDETKFTPDPMAGAVFRERYGVPSNVSLVLGIAGRLVRDKGHPLLHEAFAKITKRHPGVFLLVAGSGPWGRRYAELGKNVKVLGALEPSELSHFYNSLDVFVNPTLRPQGLDLTLMEAMHCGKPVLTPNYPSITRTVVLNEEFGYTFSPNVESLVEALESAIKDGSRELQRKGKLCQRYAVSMFTASKMASAYERFFLCMKNSRYCQYPLTSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7P1</accession>
    <name>A0A068V7P1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00018975001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739216">
        <property type="protein sequence ID" value="CDP16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7P1"/>
    <dbReference type="STRING" id="49390.A0A068V7P1"/>
    <dbReference type="Gramene" id="CDP16572">
        <property type="protein sequence ID" value="CDP16572"/>
        <property type="gene ID" value="GSCOC_T00018975001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7P1"/>
    <dbReference type="OMA" id="DEGLCCE"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7P1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF16">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="201" mass="22129" checksum="D74836A88ABB9BE4" modified="2014-10-01" version="1">MSVVTISRQNEALCGNVPSGRAFVNLTLEEVKGNEALCGNITGLRACESFPLIRKHVKDKRKELVLIIVIPLLGSFILLGAFSGIVILHDQIKKYSRAEDIKVKKGGLFAICAFDGKELYKEILKSTEEFSEIFSIGKGGYGSVYRAQLPSGDVVAVKRLHNMPNTSNWSSLVGTYGYVAPEFAYTMKVNEKCDVYSILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V854</accession>
    <name>A0A068V854_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Agenet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00019349001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
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                <person name="Lan T."/>
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                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Giuliano G."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
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        <property type="gene ID" value="GSCOC_T00019349001"/>
    </dbReference>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917">
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="424" mass="49604" checksum="03BA3328DE3F6DBA" modified="2014-10-01" version="1">MKRAPQMLQLFHKGDRVEVLKRDYSYNKDGVFVWFPAIVLQPSSTRSTNRPKNHIYVEFKTLRTIAIAVQDEDKDDDDDHNRTPLPREFVDLGDVRPAPPKELHRSLELENSWRPFVGTEIARARGKSRFWTLWRPLRKSAIVEEVEQWGLRVVRDWDDGFWVPSLELQKPSPDSDTPSQSVKLRMKYHQKSSYPKFHKGMSVEVKSDEEAPGGIPNTHDSRVTTEDETQFFKEEAGISCIRPCPPEIHQVEHFELFTQVDVWYNDGWWVGHISKVKDGFKYKVFFENTNEEIDFEHVQLRPHQDWIKDKWVAAPNELAKMGIKPRDLKLKIKCSRNIEEEKFNKGMMVEVKSDEQGYHGSWYTTAIACPIADDRFLVEYQTLRTDDESEPLLDVAKSSYIRPCPPHIQKLDSYKLLEKVDISC</sequence>
</entry>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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                <person name="De Bellis F."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </evidence>
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    <sequence length="544" mass="62142" checksum="74B9202FFD92C4E7" modified="2014-10-01" version="1">MFKLCLCRGAALCAGEFHPDDLLQLEQHIKATKKAYFSELQKYHNDMIEELRMWKDRWDGCKDPEEEILQKIWRPGRQAAKSMQFSETRFHDPEENNVATPESCSWATSEKACSNENNQNLPWDTQGRKGFSDSNLNNSSDGLKGIAKPKKVEKLQKRNIQFGDGAKYMSYIKVSKEQHQRVKRTMKHTSNSIQPRSLNNVLGNLETLHVQPFEVFEEEERQKLHDYWLQLVNKDIPVGYRSWITNKLKVQQVAKSLGQELEEKLKFQEKDGERDNYDNLELIDDIGATISPNSSAEELLYGEDEKREVSQSFLEDQKANQVIKAESSIQLEDEEDKETDNLPQQTLDVTENVEEEGESVSISAEEDREENIASISSAHQVKDMTVDSHDNSMLAKVDDLPLMVSEYPGNMNHIAIPVSHRDPSNSADDVWSAVSEPGSFYHSAAFGHQYVSSSELSLSHPQVMEEQPTNIINLEADAEEKDSERELLHREADELLMVCLSLVLILLKTEMSCLSLSSGAMMVAYLITIQIRKGWPWIFNNQII</sequence>
</entry>
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    <accession>A0A068V8P2</accession>
    <name>A0A068V8P2_COFCA</name>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
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        <location>
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            <end position="848"/>
        </location>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP17145.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1112" mass="129220" checksum="140F499E303474EF" modified="2014-10-01" version="1">MEATRIYPYSFWSHQDILIISWEKRITSSCSRPKPQEPDTDSFTAVRSQFNGYQLPSSWVYQPPQKDHKSLHPYYKKSLDILEKEARDQTKKQEWKPKLVQPIKCLNQKAEPSLNPVDKCFMFKEEDFPKLESFVKNGSRHIPKIQNAAPTVLPSGETVGPSPTEEVLNWQIENSLVQNSALTSIHKNVTEVRGKVDHIDTTVKTQNSQVSHMIKVLEERLEGLKYELPSNSSSLANFVLNKEKETQFIQNQIATLRTIGEVPKFDIGPSEPVTKVSPGFGATPIRNWPTPFYFGGVTTPNPSVFFPDQPQQSSKPFDIAQVLKRKAKEVVQEPDSSLMYTEKKANKATKIYDNPLSSMLKDFHYDLVPYISTYSQLSDSFESDQAKLSDSQVSDNEDLSVEIKTIEEEEGESSPNCEGESSPKSSYDQISSDEHIPVINMATKAEVVHPDDTYEEGERENSGASRTQRTNFPKAKGVQIFTIDNIPSEQWEAKFQEFHAWMIVQNITDESHFEILSVFTAHFARILKDWWTSLGKQDKLFFLTRQDFAENINILHLMFIGDVKESRETKRKEFFQMKCLSYDRKDLNKHFKKMTKLFIALGADINLKQAFISSFPKSLSDGAEMFIHNKYGSILNLSIGQIKQAVFLSLDDLCNKRKIIREYLKGDVCLDQACKKPELIIKGKSQACVPYKRRRKFKRFSKSYKDFPKRPFRKKLRYFKRKCKQFRGKKGNKCFIYGKPGHFAKNSPSWGSSQTQAIQRLKQELVNLPTLHIPIEDKKILQTDANEKYWGVVLFEENKQGTKHCCGFASGKFKISEQHYHSTFKEILALRNGIKKFSFFLISHHFLVKMDMGSFPKMLHFKQKSIPHPQLLRWSAWFSQYSFDVKHIMGKKNIVADFFSRKERIPQQVLSCLMFTSVQLVPPDIHEIPYPWEKEGIERIRNHYELQHFSSYDGSILSAFGTNPEYPFCQIFIANPTDFPKELLWYIWCMCHQCHILMKFQNPFFNQSLDQNLQVFLQWFKPLTYWSGLFSTNSNHTLFHFHIPCHLINNQIQSLPIPSAVIYKELTHTILDQDDEYGKAQRYIFQENRCIPPEIWPGPYGSWNFQNSHPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9M9</accession>
    <name>A0A068V9M9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="11">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00019117001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9M9"/>
    <dbReference type="STRING" id="49390.A0A068V9M9"/>
    <dbReference type="Gramene" id="CDP16658">
        <property type="protein sequence ID" value="CDP16658"/>
        <property type="gene ID" value="GSCOC_T00019117001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9M9"/>
    <dbReference type="OMA" id="ICHIASA"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9M9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF112">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPC1, CYTOSOLIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP16658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="36527" checksum="C5579B629C8005E0" modified="2014-10-01" version="1">MAKIKIGINGFGRIGRLVARVALQSDDVELVAVNDPFITTDYMIYMFKYDTVHGQYKKHELKVQDSKTILFGDKPVTVFGSRNPEEIPWGEAGADFVVESTGVFTDKDKAAAHLKGGAKKVIISAPSKDAPMFVIGVNEKDYKPDIDIVSNASCTTNCLAPLAKVLNDRFGIVEGLMTTVHSITATQKTVDGPSMKDWRGGRAASFNIIPSSTGAAKAVGKVLPALNGKLTGMSFRVPTVDVSVVDLTARLEKAATYDEIKAAMKEESETNLKGILGYTEDDVVSSDFVGDSRSSIFDAKAGIALNGNFVKVVSWYDNEWGYSNRVVDLIRHMAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA24</accession>
    <name>A0A068VA24_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00002749001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739243">
        <property type="protein sequence ID" value="CDP17407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA24"/>
    <dbReference type="Gramene" id="CDP17407">
        <property type="protein sequence ID" value="CDP17407"/>
        <property type="gene ID" value="GSCOC_T00002749001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA24"/>
    <dbReference type="OMA" id="GECIVIH"/>
    <dbReference type="OrthoDB" id="1289445at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="125" mass="14789" checksum="CF38E935B60D48A9" modified="2014-10-01" version="1">MKHFLEFVLIYHGLGIWGFLILFWYLRRLRRMRDRLIEMKQWCDEVMREEDEEDDCEGAEDEKVLSKAAVLGFMQMLMQDDDGGYAEEAVSVEWAEKCLSIHFKCPCGKGYQILLSGNNCYYKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAB4</accession>
    <name>A0A068VAB4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intron-binding protein aquarius N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00004490001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739251">
        <property type="protein sequence ID" value="CDP17532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068VAB4">
        <property type="interactions" value="3265"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAB4"/>
    <dbReference type="Gramene" id="CDP17532">
        <property type="protein sequence ID" value="CDP17532"/>
        <property type="gene ID" value="GSCOC_T00004490001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAB4"/>
    <dbReference type="OMA" id="YRVWLDC"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="5">
        <location>
            <begin position="556"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="6">
        <location>
            <begin position="775"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1558" mass="177748" checksum="6DDD02390880545F" modified="2014-10-01" version="1">MKVYGTGVFDFRRHRVAEYPVEGPLPAGAAESAVPDKSLESKPGTNLSTSITLTEIQRDRLTKIAAANWAKTGDSTSAKKPFSPQLVKEIYDNELTVKGGRKPVPLQRVMILEVSQYLENYLWPNFDPETATFEHVMSMILMVNEKFRENVAAWVCFHDNKVMFMAFLERVLCLKEGRNFSVAEKINYLLFMINGFQSLEDEIVSEKVLRVASLQSWHSLSYGRFQIELCLNPDLIKKWKKITRRAKEAAKRGESLEASSMMEVRFLRNLIEEFLEVLDSNVFHHQQQDDESDQSVNIGDPEQVDDACVLYCERFMEFLIDLLSQLPTRRYIRPLIADVAVVSKCHLSALYRHRKGKLFSQLVDLLQFYENFEIDDHLGRQMADDEVLQAHYERLQAFQLLVFKKIPKLRELSLANIGAINKRADLSKKLAVLSPEELRDLVCVKLKLLSKSDPWSERVDFLIEVMVSFFEKQQSQKEAINALPLYPNEQIMWDESLVPSINYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIREDIQEAVPHLLAHINNEGETAFRGWSRMAVPIKEFKITEVKQPNIGEVKPSAVTAEVTFSISSYKAQIRSEWNALKEHDVLFLLSICPSFEPLTADEAAKATVPQKLGLQYVRGCEVIEMRDEEGTLMNDFTGRIKRDEWKPPKGELRTVTVALDTAQYHMDVSDIAEKGAEDVYGTFNVLMRRKPKENNFKAILESIRDLMNETCIVPDWLHDIFLGYGNPSAAQWINMPDLLEVVDFKDTFLDADHVRECFADYQVCFTNSDGTENANPSPPFRIKLPRSLKGDAHALPGNKKSISALGDAANATDVHSNGEKLVVEAYTPPDHGPYPQDQPKQNSVKFTPTQIGAIISGIQPGLTMVVGPPGTGKTDTAVQILNVLYHNCPSQRTLIITHSNQALNDLFEKIMQRDVPARYLLRLGQGEQELATDLDFSRQGRVNAMLVRRLELLSEVERLARSLQLPEDVGYTCETAGYFWLLHVFSRWEQFLAASEKNQDKATFVQDRFPFKEFFSNAPQPIFTGQSFESDMRAAKGCFRHLKTMFKELEECRAFELLKSTVDRSNYLMTKQAKIVAMTCTHAALKRKDFLQLGFKYDNLLMEESAQILEIETFIPMLLQRQEDGYARLKRCILIGDHHQLPPVVKNMAFQKYSHMDQSLFTRFVRLGIPYIELNAQGRARPSLARLYNWRYRELGDLPFVKDNQIFHKANAGFCYDYQLVDVPDYNGRGETAPSPWFYQNEGEAEYIVSVYMYMRLLGYPANKISILTTYNGQKLLIRDVINRRCAPYDFIGPPNKVTTVDKFQGQQNDYILLSLVRTRFVGHLRDVRRLVVAMSRARLGLYVFCRRSLFEQCYELQPTFQLLLRRPDQLALNLHEVIPYTDRHVEDTGIVHLISGIEEMAGIVNYKMHQIYQARAMSHQLAAYSGHVPMAVDASDENSLSSSTVRGALESDPHRDNGINGEVSPENESNESTAKDLLANGNNDMPPGSKSNGNVDLKVQGDDLDGMEISGSAEEESKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBH2</accession>
    <name>A0A068VBH2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00007056001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VSR (BP-80) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739302">
        <property type="protein sequence ID" value="CDP18160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBH2"/>
    <dbReference type="FunCoup" id="A0A068VBH2">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBH2"/>
    <dbReference type="Gramene" id="CDP18160">
        <property type="protein sequence ID" value="CDP18160"/>
        <property type="gene ID" value="GSCOC_T00007056001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBH2"/>
    <dbReference type="OMA" id="VHAEAQP"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000178">
        <property type="entry name" value="vacuolar-sorting receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000001">
        <property type="entry name" value="Vacuolar-sorting receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056858">
        <property type="entry name" value="VSR_TRX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF4">
        <property type="entry name" value="VACUOLAR-SORTING RECEPTOR 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25011">
        <property type="entry name" value="VSR_TRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658442" evidence="16">
        <location>
            <begin position="28"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="17">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting receptor thioredoxin-like" evidence="18">
        <location>
            <begin position="192"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP18160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="632" mass="70216" checksum="45C24D4C7D08DFBD" modified="2014-10-01" version="1">MANTLFSRAFLIVSTLVLSSTSFLTEARFVVEKSSISILDPSDIRSKHDAAIGNFGVPDYGGSMVGTVVYPDTGATGCSPFEGDKPFRSKSSTPTILLLDRGGCYFALKVWNGQQAGAAAVLVADSVDEPLITMDSPEESSDADGYLEKIGVPSVLIDHSVGESIKGALKKAANVVVKIDWSESMPHPDQRVEYELWTNSNDECGIRCDEQMNFIKNFKGNAQILEKGGYTRFTPHYITWYCPHAFLLSSQCKSQCINHGRYCAPDPEQDFGMGYQGKDVVFENLRQLCVHRVANESNRSWVWWDYVTDFHIRCSMKQKKYSKECAEEVMRSLHLPIEKIKSCMGDPEADVENQVLKIEQDLQVGRGSRGDVTILPTLVINDVQYRGKLERIAVLKAICAGFKETTDPPICLNGDLETNECLENNGGCWQDSHSNITACKDTFRGRVCQCPSANGVQYRGDGYKSCEAVGPGRCMVNHGGCWSETRHGLTVSACTESDLTGCHCPPGFTGDGYKCEEIDECKEGKVCQCDDCTCKNTWSGFECGCRGDKLYILEHDTCIERHTSKFGWFLTLLVLAAVVAASMAGYIFYKYRLRSYMDSEIMAIMSQYMPIDNQQNQVVHHEAEPLQQRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBY1</accession>
    <name>A0A068VBY1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00006460001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="HG739292">
        <property type="protein sequence ID" value="CDP18097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBY1"/>
    <dbReference type="FunCoup" id="A0A068VBY1">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBY1"/>
    <dbReference type="Gramene" id="CDP18097">
        <property type="protein sequence ID" value="CDP18097"/>
        <property type="gene ID" value="GSCOC_T00006460001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBY1"/>
    <dbReference type="OMA" id="WGCKFDA"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000382">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF51">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="75"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="547"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP18097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="676" mass="74180" checksum="D8497DAAED70B609" modified="2014-10-01" version="1">MQEILGSVRRSLVFRSPTSAGDGGVGGAGEDGTIVDRINSCLRKSRVFSKPSPPRLPPQTMTAGENAAAVQSIRWRKGELIGCGAFGQVYMGMNLDSGELLAVKQVLIPANSASKEKAQVYVQELEEEVKLLKNLSHPNIVRYLGTVREEETLNILLEFVPGGSISSLLGKFGSFPESVIRMYTKQLLLGLDYLHKNGIMHRDIKGANILVDNKGCIKLADFGASKQVVELATVSGAKSMKGTPYWMAPEVIRQTGHRFSADIWSVGCTVIEMATGKTPWSQQYKEVAAFLFYIGTTKEHPPIPEFLSAEAKDFLLKCLEKEPELRPSASELLQHPFVTGEILLPSVATSTSVMKNSEPLYSCGENLGDTAGSDDVCNLGSLDFSTINCQKFSEGRHSLGQNRISDEICQIDEKDNLVVGKAHFSDIMITDESCKSFNPICEPCEDWTTNYDASPEVEKSSIKLDMKQEIDRPTGCSPSPGESKNVFSFCSAPSVDEDDDEVTESKIRAFLVEKALELKKLQSPLLAEYHNSFNPLCSPNLSDAKGDESASKFLKLPPKSRSPSRTPSTAVESATDASPGSSSRRASHIGVRTNEDHQQNLSPQTNDLNGNLADTQEPCSPNVMEIQRKWKEELDQELERKREMMRQAGMGGKTSSPKDRALNRPRERSRFASPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC50</accession>
    <name>A0A068VC50_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00004331001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739307">
        <property type="protein sequence ID" value="CDP18306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC50"/>
    <dbReference type="Gramene" id="CDP18306">
        <property type="protein sequence ID" value="CDP18306"/>
        <property type="gene ID" value="GSCOC_T00004331001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="25" mass="3259" checksum="28EECEE7D2744EE6" modified="2014-10-01" version="1">MTLDLYKEDYIELIIFIWYMSCLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCD9</accession>
    <name>A0A068VCD9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00009694001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="HG739239">
        <property type="protein sequence ID" value="CDP17353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCD9"/>
    <dbReference type="FunCoup" id="A0A068VCD9">
        <property type="interactions" value="3530"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCD9"/>
    <dbReference type="Gramene" id="CDP17353">
        <property type="protein sequence ID" value="CDP17353"/>
        <property type="gene ID" value="GSCOC_T00009694001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCD9"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCD9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="317" mass="35979" checksum="47FD5D82B6D7976B" modified="2014-10-01" version="1">MSSDSAVPSPGSVHGGSLDEQISQLMQCKPLSEQEVRLLCEKAKEILMDESNVQPVKSPVTICGDIHGQFHDLAELFRIGGKCPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKIFTDLFDYFPLTALVESEIFCLHGGLSPSVETLDNIRNFDRVQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEQFNHTNNLKLIARAHQLVMEGFNWAHDQKVVTIFSAPNYCYRCGNMASILEVDDCKGHTFIQFEPAPRRGEPDVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCJ6</accession>
    <name>A0A068VCJ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012022001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCJ6"/>
    <dbReference type="STRING" id="49390.A0A068VCJ6"/>
    <dbReference type="Gramene" id="CDP18292">
        <property type="protein sequence ID" value="CDP18292"/>
        <property type="gene ID" value="GSCOC_T00012022001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCJ6"/>
    <dbReference type="OMA" id="PWRNKRY"/>
    <dbReference type="OrthoDB" id="691424at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCJ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006502">
        <property type="entry name" value="PDDEXK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01615">
        <property type="entry name" value="A_thal_3542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31579">
        <property type="entry name" value="OS03G0796600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31579:SF34">
        <property type="entry name" value="T14N5.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04720">
        <property type="entry name" value="PDDEXK_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="24601" checksum="84BED010D852F71A" modified="2014-10-01" version="1">MSSSDDEKLSQMIRDYIELDPSSPISSSKSLQVDQKSSFMYLQEILERVTVAESEILRKIFLYWKDLEPSKLRKWVVMNLGKDYYDASLCRTSWVTKFNRSSGEYEYIDVMMKNDATSDGAVRLIVDIDFRSQFELARPTPEYEELSNSLPSIFVGTELKLEKIISLVCSAAKESLRERGLHVPPWRKARYMHSKWLSENCKKISFPELGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDE2</accession>
    <name>A0A068VDE2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00002668001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739362">
        <property type="protein sequence ID" value="CDP18736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDE2"/>
    <dbReference type="STRING" id="49390.A0A068VDE2"/>
    <dbReference type="Gramene" id="CDP18736">
        <property type="protein sequence ID" value="CDP18736"/>
        <property type="gene ID" value="GSCOC_T00002668001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDE2"/>
    <dbReference type="OMA" id="YIDIETH"/>
    <dbReference type="OrthoDB" id="1884766at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDE2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288:SF27">
        <property type="entry name" value="CYSTEINE_HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288">
        <property type="entry name" value="PHORBOL-ESTER/DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP18736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="398" mass="45439" checksum="AECBA7E90B4FF986" modified="2014-10-01" version="1">MLDEPCAAHGQEIKHPFHSQHTLSLVLYYVRPPRCCSLCGGGGRNGYFFTCSSCDFCLDVDCANLGETTTICKADQGHIQIQPVTHPHPLIQVEVMISMKNFRSCCFACGLRFEDLVYACLSCGILLHKSCADLPNEITSHLHPNHLLKLVKNSFWYHKRFSCQVCLQSTGHFFYSCGECDFGLDVKCTRSAFPLIMSKYHEHALAYIDIETHNFECVLCIGICRQFYFRCLRLDCNFSIHDHCYPSLPLSIKDDCHIHPLTFADYPIKGVPDDPEKEAELYCYACEEGRAFDRITYFCSSCHFVAHVHCVITAIISYLHKEPSHLAITSIGEQLGSTGDSADEDAVLHQLDEELMRLEKDVQALMAKIGELRQRRYEHISKRTTSRRNYLLEKRDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDG7</accession>
    <name>A0A068VDG7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00001430001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739257">
        <property type="protein sequence ID" value="CDP17698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDG7"/>
    <dbReference type="FunCoup" id="A0A068VDG7">
        <property type="interactions" value="1582"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDG7"/>
    <dbReference type="Gramene" id="CDP17698">
        <property type="protein sequence ID" value="CDP17698"/>
        <property type="gene ID" value="GSCOC_T00001430001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDG7"/>
    <dbReference type="OMA" id="KQHWKLG"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDG7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36598" checksum="86719A81D3F68227" modified="2014-10-01" version="1">MSGARFGFALDEELRKAASDEEVKAAIANKISRERIGHEIDLMVSGNQPVKAMTYVSDLQLFGAVFSLPLEFEPEIPDRYDRVCVADFDSAWRLLEAIGCPFSADQQRLFLYAALFLPFRENVYKEKKAKKIPVVSYIIRNSLKLKASDAEMVISLHIATKKFVSLIPFVVSKEDIQILEVDWKREIIDVPFASKLRILAGLLLRDIKDFWRAALLLSMLLYPTDIYSATSSFEFDKRREVYNMVEEAILGKGLDKVWEVKPLVDGKEIMSILDLKTGGPLVREWQQKLIEWQLAHPFESKDKCIQWMNEASSKRARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFG3</accession>
    <name>A0A068VFG3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00004053001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739491">
        <property type="protein sequence ID" value="CDP19284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFG3"/>
    <dbReference type="STRING" id="49390.A0A068VFG3"/>
    <dbReference type="Gramene" id="CDP19284">
        <property type="protein sequence ID" value="CDP19284"/>
        <property type="gene ID" value="GSCOC_T00004053001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFG3"/>
    <dbReference type="OMA" id="MIAMHIS"/>
    <dbReference type="PhylomeDB" id="A0A068VFG3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000445">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000416">
        <property type="entry name" value="Probable leucine-rich repeat receptor-like protein kinase At5g63930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF163">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="349"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP19284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="635" mass="70170" checksum="244E30C4902569AF" modified="2014-10-01" version="1">MRTNFLVPFRNLTNLIKLYLQNNQFSGSIPVTFGNLNRLVNLSLDQNHLSGPIPPVIGNLSSLQFLYLYQNNLTGAIPKSLGNLTNLIKLDLSENQLSGSIPASIGNLSTLKVLYLYNNQFSGSIPATFGNLNRLVKLDLAFNQLSGSIPVSIGNLSDLEILALAENQFSGTIPQELGNLNKLVDLRLFSNHFSGPLPELLFAKNNITGGIPPEIGNLTQLHKLDLSSNYLSGEIPREVVKLTSMLTLDLHDNQLTDLSTNSLIGTLPELLGDLKHLFHMNLSNNVFGQKIPSQIGKLTQLSELDLSQNLFTGEIPSEFQNLQSLLHINLSFNNLEGPIPSGRAFVNLTLEEVKGNKGLCGNITGLRASEDMEVNKGGLFAICAYDGKALYKEIVRSTEEFSETYCIGKGGCGSVYKAKLPSGEVVAVKRLHNIPNHSILVYEYLERGSLAKILSIEEAAKELDWQKRLNIIKGVAHALSYMHHDCSPPIVHRDISSNNILLDPECEAHISDFGTSKFLRRDSSNWSSLAGTYGYVAPEFAYTMKVNEKCDVYSFGVLTMEVIKGKHPGDLIANLLSSKLEEIELKDLLDQRLQYPNQEIEKNLISILKLARECLHVDPQCRPTMLIISRLISTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFH2</accession>
    <name>A0A068VFH2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00001495001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739495">
        <property type="protein sequence ID" value="CDP19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFH2"/>
    <dbReference type="FunCoup" id="A0A068VFH2">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFH2"/>
    <dbReference type="Gramene" id="CDP19294">
        <property type="protein sequence ID" value="CDP19294"/>
        <property type="gene ID" value="GSCOC_T00001495001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFH2"/>
    <dbReference type="OMA" id="WKSKTYS"/>
    <dbReference type="OrthoDB" id="10266693at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009657">
        <property type="term" value="P:plastid organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13661">
        <property type="entry name" value="PBP2_PotD_PotF_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30222">
        <property type="entry name" value="SPERMIDINE/PUTRESCINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30222:SF17">
        <property type="entry name" value="SPERMIDINE_PUTRESCINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="480" mass="53529" checksum="6F25837DF6882413" modified="2014-10-01" version="1">MKIEVKSSPDSKSEVKKTFLFSIVQLVQPKFHSTFCPDRCLVSNLGDVKKSENLEEAEADELKAAFERWKSKTYALSVPLRVVALRNSLPSIWFQEFIQSQGKRVKLQPEFRQNLTDIFSELCQSNNKGAVSPKSAMAADVVTLGDSWLSFAIKEGLIQPIQGVEEQDWFRDLTEDWKGYLRRSTDGNLDPQGKIWAVPYRWGSLVIAYKKSKFLKHKLAPVVDWADLWRPELAGKISMVDSPREIVGAVLKYMGASYNTHNITSQVAGGKSALKEKLALFAKQVRLFDSQYYLKAFGVGDVWVAVGWSSDILPAAKRMSNVAVVVPKSGASLWADFWAIPATSRVKTGNVGGRVRGPSPLVSQWIEFCLQSARALSFKEEAIPGALPIVFQDPVQGSGNLHKGQPKLETNLIACMPPPDILARCEFLEPLPEDTMADYQWLIANMKKPKQSVMQILQHYILLIVRSLLAIVQSKGGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHK0</accession>
    <name>A0A068VHK0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003962001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740164">
        <property type="protein sequence ID" value="CDP20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHK0"/>
    <dbReference type="Gramene" id="CDP20290">
        <property type="protein sequence ID" value="CDP20290"/>
        <property type="gene ID" value="GSCOC_T00003962001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHK0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="44" mass="5208" checksum="173C277618A57BFF" modified="2014-10-01" version="1">MVGEKGKKMKRKALKWKRLVEAATQKVYFNLENVINQVLLNPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHN0</accession>
    <name>A0A068VHN0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00002434001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739983">
        <property type="protein sequence ID" value="CDP20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHN0"/>
    <dbReference type="STRING" id="49390.A0A068VHN0"/>
    <dbReference type="Gramene" id="CDP20099">
        <property type="protein sequence ID" value="CDP20099"/>
        <property type="gene ID" value="GSCOC_T00002434001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHN0"/>
    <dbReference type="OrthoDB" id="1692590at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="147" mass="16899" checksum="52CC4CDF8B014EAD" modified="2014-10-01" version="1">MAERRGGGCCPPMDLMRSEPMQLVQLIIPAESAHLTTDYLGELGLVQFEDLNAEKSPFRQTYTTQIRRCLSKQGSKQERLRQETEAAKNRAAEAAALARSHHPHLVGVHRHRQIFAEKIYAVRDPFSLKFIFLFKFIFLSLKQRMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK99</accession>
    <name>A0A068VK99_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2302</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00001087001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741386">
        <property type="protein sequence ID" value="CDP21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK99"/>
    <dbReference type="SMR" id="A0A068VK99"/>
    <dbReference type="STRING" id="49390.A0A068VK99"/>
    <dbReference type="MEROPS" id="I03.030"/>
    <dbReference type="Gramene" id="CDP21024">
        <property type="protein sequence ID" value="CDP21024"/>
        <property type="gene ID" value="GSCOC_T00001087001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK99"/>
    <dbReference type="OMA" id="DLNIMFP"/>
    <dbReference type="PhylomeDB" id="A0A068VK99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23375">
        <property type="entry name" value="beta-trefoil_STI_VvMLP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011065">
        <property type="entry name" value="Kunitz_inhibitor_STI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002160">
        <property type="entry name" value="Prot_inh_Kunz-lg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107:SF5">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00197">
        <property type="entry name" value="Kunitz_legume"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00291">
        <property type="entry name" value="KUNITZINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00452">
        <property type="entry name" value="STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50386">
        <property type="entry name" value="STI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658734" evidence="2">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="207" mass="22721" checksum="AA789905D5CBAC20" modified="2014-10-01" version="1">MKISLLFLISFLPFFISTVSSFASAAEPEPVLDVAGNVLRTDLYYYILPANVRGRFGGGGLTLSSIGNDTCPVGVFQELSAQRNGIPVTFSPVKPRNGVVRISTDLNIEFAYPETCGESPVWRVDNYLDPSADSFVSIGGVVGNPGPATLGSWFKIQKFGYDYKLVYCPTVCSYCDVICKDVGILYQNGERRLFLIDYPLRVVFKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKB3</accession>
    <name>A0A068VKB3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_2599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00011617001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741683">
        <property type="protein sequence ID" value="CDP21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKB3"/>
    <dbReference type="Gramene" id="CDP21141">
        <property type="protein sequence ID" value="CDP21141"/>
        <property type="gene ID" value="GSCOC_T00011617001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKB3"/>
    <dbReference type="OMA" id="HCINCES"/>
    <dbReference type="PhylomeDB" id="A0A068VKB3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="184"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="438"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="666"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP21141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1269" mass="144120" checksum="F1F410345B183182" modified="2014-10-01" version="1">MADALVGATIRITLEKAVGIASDQIGMVYGFKKDLVKFKASVEMILAVLADAEEEQPKQQAVQLWLKRLEGLAYEADNALDELNYDVLRQQVETGKRNGNQLKGKVRSLFHSNSIGFRWKMGQKIRDLNKKLNIINEEANSFGLKSQLGGSGTKATLLPDIGRTVMVNRETDSVVFPNIVGREHDKFKIVQKISSETSNVIYVLPITGMGGLGKTTLAQSIFNDQQIERHFDLKIWVCVSEDFEVTRIFRLILESLTRRKVDVASRDVIVQEIRKEIEGKRYLLVLDDLWNEIPLLWTDFYRSLTGISTTRGNWCLVTTRQLQVATVVATYPPYSLGKLSDDDCWTIIKDKMIGSGEVTEELQAQEKEITKWCQGLPLAAIVIGGLLRMRRKEERLSIVNNGLLKFTGDDSSVMQILKLSFDHLPSPSIKKCFAYCSMFCKDFKVERRKLIQLWMAEGFLQSNLENEVMEEIGDKYFRVLVESSLLQEEISSDKRTFGTMHDLVHDLAQSISRCESIVLNSSGEITPRNFDVISSSLRSLFPRSSIPEDLVPKLKNLRVLDLSSANIVELPTSIGKLIHLRYLEFPYTLTKTLPESLCKLYNLQTLKFNCISPMDLPEQMSKLISLRHLCYYNNDRKVQMPLGMGRLTCLQTLDFFNVGEEKGRQIEELGCLRHLKGFLRIRNLELVKGKEAAERAKLFEKQNLSSLSLEWGGRWEDDGADINVLEGLQPHPHLQVLEVENFMSGQFPLWLMNPATSLEKLVWLRLVNCRRCTELPALGQLPFLQSLAMIGLEKVTVIGHSFYGLCNPSGSRSSRSSSQLSRKVFPHLKSLYLNNMNNLVVWMEAEAREGEVLDVFPMLETLKIQNCYKLNRAPNYFPCLRQLLKTPNKSHALVLKDILSKATTLSTLRIGGQAGLTCVSDVLAVHNSQNLKYLSLESCPHLLHLGDLHKLLSLEHLSVVRCPNLKTIDLIVPNDQQHLTSLRSLTIGQCNGLRSLPSEILELNTSLRELRLYECHNLVWFPVDLQQMPSLSVLWLSNCPKLTTMPQGFGGLTSLRELCIGPFSDTSMENYGYDWLALCSFFPVRKLTLQGWPRSESLPNQLQNLTALIELHLFGFGIEALPEWLGNLVNLEELEVVNCAKLRTLPSMAAMRRLTKLSDLLIKLCPLLEEICTPQSGPDSEWSKINHIPHIFVGQMTVQYLPCKILNLQITCNSFVGFPQKKSLLFAVSNLFPYFLLFYFFNFWIFFLLDMNISNFGLLVSELLHQFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLH9</accession>
    <name>A0A068VLH9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00004614001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG743373">
        <property type="protein sequence ID" value="CDP21464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLH9"/>
    <dbReference type="STRING" id="49390.A0A068VLH9"/>
    <dbReference type="Gramene" id="CDP21464">
        <property type="protein sequence ID" value="CDP21464"/>
        <property type="gene ID" value="GSCOC_T00004614001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLH9"/>
    <dbReference type="OMA" id="MEIALNC"/>
    <dbReference type="PhylomeDB" id="A0A068VLH9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF602">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="259"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="569"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP21464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="839" mass="94234" checksum="C15F9D0744C620DA" modified="2014-10-01" version="1">MTYQENSRRNWELEQSMDFESTWKSVEWIHSSGNQSNTTSLGEVNFGWNLLNSSIPASLCNLNNLLALNLSSNALTGSLPQEIQNLQALADLDLSRNHLNGKVPSSIGGLERLASLSLAHNRLEGTIPDSLRHMLSLEILDLSNNNLSGPIPKSLETLLYLRYINLSFNHLTGEIPSSGPFKTFTYESFMCNDDLCGAQRFHVPPCSSPRIHSRKKILQISGIVSSIAAIDETSRNTDLSMGVPKWISYYDLVQATDGYDESNLLGKGSFGSVYKGTLTDGTLVAVKVFSLLVEITSKSFDTECEVLRNLRHGNLTKVIGSCSNLDFKALVVDYMSNGSLENLLYSNDHCLDLVQRISIMVDVASALEYLHFGYVTPVVHCDLKPSNLLLDENMIAHVSDFGITKFLDEGNSVLHTETLATLGYMAPEYGLEGLVSTRIDVYSFGIVLMETFSRMKPSDEMFSEDLSLKSWIVKSLPTATIISMIFNLALSCSTECRQDRMNMKDVLAALKKIKRQLDTLSDTSARKHFRVLCVCTESISRKICLEIVCLIANDPFLLNTPTRHQNTSAGQSNLLGTGGFGSVYCGTLNDGRKVAVKVFHVQLERALESLDTECEVLRNLRHRNLTKVISGCSNNDFKALVLELMPNGSLEKWLHWPSCFLDMKQRLNIMIDLASALHYLHNGYSIPVVHCDLKPSNVLLDQDMIAHFTFKILHSFFFFCQNLDWKDSYSTKCDVYSYGIMLMEVFTRTKPNDERFNGNSSLKGLVQSSMPNAPYQIIDTNLLQEDEEHFAEKLDCISFIMEIALNCSRESSRERSNMETVLREMNNIKYKLLSIDRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMM5</accession>
    <name>A0A068VMM5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_9244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00001372001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG748328">
        <property type="protein sequence ID" value="CDP22030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMM5"/>
    <dbReference type="STRING" id="49390.A0A068VMM5"/>
    <dbReference type="Gramene" id="CDP22030">
        <property type="protein sequence ID" value="CDP22030"/>
        <property type="gene ID" value="GSCOC_T00001372001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMM5"/>
    <dbReference type="OMA" id="KNDICMT"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMM5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP22030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="146" mass="16488" checksum="ED823182CD80A011" modified="2014-10-01" version="1" fragment="single">MDAIIQAPYDATVRLMLASLERNLLPDAVIRRLTRLLLAGRLRSGYKPTSEQQLSDLLAFAHSLREMPTAIQTEVPKSQHYELPTSFFKLVLGEHLKYSCCLFLDKSKTLEDAEKAMLELYCERSQIKDGHTVLDVGCGWGSLALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN88</accession>
    <name>A0A068VN88_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DH200=94 genomic scaffold, scaffold_2631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00008820001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a key role in the control of the eukaryotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG741715">
        <property type="protein sequence ID" value="CDP21158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN88"/>
    <dbReference type="FunCoup" id="A0A068VN88">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VN88"/>
    <dbReference type="Gramene" id="CDP21158">
        <property type="protein sequence ID" value="CDP21158"/>
        <property type="gene ID" value="GSCOC_T00008820001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN88"/>
    <dbReference type="OMA" id="PGTCLRE"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN88"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000281">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase B2,2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP21158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="314" mass="35469" checksum="98BECAEA4DDA7964" modified="2014-10-01" version="1">MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGVPPTALREVSLLQMLSQSLYVVRLLCVEHIVDGNKKNGGSDSGNGKPLLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPSLIQSFLFQLCKGVAHCHSHGVLHRDLKPQNLLVDKDKGILKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTAVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEKQWPEVCSLRDWHVYPQWEPQNLARAVPSLGPDGVDLLSKMLKYDPAERISAKAALEHPFFDSLDKSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNA7</accession>
    <name>A0A068VNA7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_10609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00001943001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG749693">
        <property type="protein sequence ID" value="CDP22117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNA7"/>
    <dbReference type="Gramene" id="CDP22117">
        <property type="protein sequence ID" value="CDP22117"/>
        <property type="gene ID" value="GSCOC_T00001943001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNA7"/>
    <dbReference type="OMA" id="MRMSING"/>
    <dbReference type="PhylomeDB" id="A0A068VNA7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP22117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="136" mass="15515" checksum="E23716206BB849AD" modified="2014-10-01" version="1">MNFGDFDKAIMVYGSMRKHNVKPDSVTYNVLISGCCKMSKFSNALEFLNEMLDLKVPLSQEILPYLNLSLSLSQGQLTGAESMFSMMKMAGFHPDVVTYTAMLHAYSVADDWEKAFAIFQEMELHGVQQFKEWFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TL22</accession>
    <name>A0A068TL22_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014099001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TL22"/>
    <dbReference type="FunCoup" id="A0A068TL22">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TL22"/>
    <dbReference type="Gramene" id="CDO96916">
        <property type="protein sequence ID" value="CDO96916"/>
        <property type="gene ID" value="GSCOC_T00014099001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TL22"/>
    <dbReference type="OMA" id="NYAWREL"/>
    <dbReference type="OrthoDB" id="641593at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TL22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36806">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654052" evidence="1">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO96916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="219" mass="24874" checksum="B57663548FF83EDE" modified="2014-10-01" version="1">MLTSLMKNKLFSFLLFFFLLFAPSPTFSLSFPLSNYGTLLSLSHSLAVRVANLRASRGDFTGSARARTIAYKIESVQGFGLWKFTWNLGSDYLKNYAWRDINTVSITDLSFAVSDLNELLRELNELSRVGSDSERVAWVGRNYNRVFTVSRSLFDKLLKIFRQSGPFREVVETMQKEVVEGDLLRDCLELGTNDLKGLIQVLKDMAAQYTASTFSRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLX2</accession>
    <name>A0A068TLX2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00014638001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in the defense reaction of plants against pathogens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLX2"/>
    <dbReference type="FunCoup" id="A0A068TLX2">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLX2"/>
    <dbReference type="Gramene" id="CDO97325">
        <property type="protein sequence ID" value="CDO97325"/>
        <property type="gene ID" value="GSCOC_T00014638001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLX2"/>
    <dbReference type="OMA" id="GCAMALN"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLX2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05381">
        <property type="entry name" value="CAP_PR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000006">
        <property type="entry name" value="Putative pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654007" description="SCP domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="8">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO97325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="162" mass="18007" checksum="FF54DFDE04CB2832" modified="2014-10-01" version="1">MGSPKISLALVSFILLAIFWPSRAQNSQQDYVDAHNAARAQVGVGPIAWDDTVAAYAQNYANQRINDCNLVHSGGRYGENLAEGSGDLTGRDAVNLWVSEKQYYDYNSNTCAQGQQCGHYTQVVWRDSVRLGCARVQCTNNGWWFVICSYDPPGNYVGQRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM48</accession>
    <name>A0A068TM48_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014224001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM48"/>
    <dbReference type="FunCoup" id="A0A068TM48">
        <property type="interactions" value="2904"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TM48"/>
    <dbReference type="Gramene" id="CDO97014">
        <property type="protein sequence ID" value="CDO97014"/>
        <property type="gene ID" value="GSCOC_T00014224001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM48"/>
    <dbReference type="OMA" id="AGYVWDV"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM48"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12413">
        <property type="entry name" value="RRM1_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="274"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="502"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="654"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="888"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="951" mass="105562" checksum="D650F76B515FFED6" modified="2014-10-01" version="1">MGKKKKVKATDGDSQYSPSTVFVTGLPYSLTNAQLEESFSEVGPIRRCFMVTKKGSSEHRGFGFVQFAAVEHANRAIELKNGSTVGGRKIQVKHAMHRASLEQRRSKGNQAEISDGVAQAKDNKLSLSAKTVEHEEFSKSLSTVNETLESLEKRKAATTSSSIADEETSLEKEKQRVAKTVIFGGLLNTAMAEDVHRLARECGTVRSIIYPLPKEELEHHGLARDGCKMDASSVLYTSVKSARSSVAALHQKKIHGELLWARQLGGEGSKTQKWKLIVRNLPFKATVNEIKNMFSAVAFVWDVFIPQNPETGLSKGFAFVKFTSKQDAENIIKMFNGKNFGKRPIAVDWAVSKKVYASGGKSLDAGEEGPDKHGEESDSDGDLDEDDTEVNEKSLQDYKVDGMSDGSDSTEEKVSGSETNFDEEADITRKVLQNLISSTSKATDSLDNDNSGLSKEMKDDESLGISSKLSDTFIAPNTIPGNSGKNKQIEKNPTERDNELQRTIFISNLPFDSSSEEVKQRLLAFGEVESFLPVLHHVTKRPRGTGFLKFKTSDGADAAVSAANAAAGLGIFLKGRQLKILKALDKKAAQDKVSEKTKKENRDHRNLYLAKEGLILEGTPAAEGVSVSDMSKRKMLQEKKMTKLKSPNFHVSRTRLAMYNLPKTMSEEELKQLCIHAVTSRATKQKPVIRQIKILRESKNTNSTRKNSSRGVGFVEFSEHQHALVALRVLNNNPETFGPEQRPIVEFAVDNVLTLRSRKDKLQARQQDSLNGVQDLQQNDKSSALDYHSKEKSRKRKSRHDAKASDTSGSKTEAEVGRQVFAESPSGEVRVVKKQKGDAGGKRDNISFKKKMRSSKNKQIPDQEQRNPDGGVPHPAEGTTISAHKPQKHEEPVGPEIRKKSKRNSDPLGRDVVDKLDTLIEQYRSKFARRDADQTDHEKRGSKQIRRWFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TND1</accession>
    <name>A0A068TND1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014818001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TND1"/>
    <dbReference type="FunCoup" id="A0A068TND1">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TND1"/>
    <dbReference type="Gramene" id="CDO97469">
        <property type="protein sequence ID" value="CDO97469"/>
        <property type="gene ID" value="GSCOC_T00014818001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TND1"/>
    <dbReference type="OMA" id="RKEYSSH"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TND1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="397"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="656" mass="70964" checksum="720B557244CFAAB4" modified="2014-10-01" version="1">MADCLCSILNSRAITSLSLLIPRCPPQNPFISLPALSFANPRVPRRRKEKQLLFCISNNESSSSISSSSKIDIISTREHSDGSIVFQFGDPREAMKDDELKQSSLSNKGGESDGQVESRVVKVLDGDHERKVIVKKMEREVRVHSSNLVADSGTSGVVSTNEESSTSSFLEGPSKSSEKLNAEVPVSGLSVEKVWNVSSSELNANTLIDADDTLSTVSVLEKRSKKESGETSEVLLDGKGDNEVVQQLVSVKPDSPTEVTDTVHQESDSESVELLDLPGDSESHSLESGINNIIMDDSSDSDTIEVMPVSPQTDAEPTLDEEAGCIAVDTFGEEDTSIQISEIKSDQSIVLSEAGIGLDKLQRSDNSERSSLEIIQLESPEVPVDGEEIPIAEIVLSSAAALLPHPAKLLTGGEDAYFISGRYWLGIADGVGRWSDRGIDAGVYARELMENCEKIVSEGNGSITIGRGRRRVRVRATPEEVLSLSVAESQSPGSSTVLVAHFDGQALHVVNIGDSGFLILRNGVVFERSHRMTYKFNFPYQIQRGHDPSELLEEYEIELEEGDVIIIATDGLFDNLYEQEIVSIVSASLSAGRRPKRIAEMLAAGAQEVGRSSTERSPFTDAARAAGDPTRKGGKLDDVTVIVSLVRKEYSSHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNX1</accession>
    <name>A0A068TNX1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00014287001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNX1"/>
    <dbReference type="FunCoup" id="A0A068TNX1">
        <property type="interactions" value="2963"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNX1"/>
    <dbReference type="Gramene" id="CDO97063">
        <property type="protein sequence ID" value="CDO97063"/>
        <property type="gene ID" value="GSCOC_T00014287001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNX1"/>
    <dbReference type="OMA" id="FSHINSW"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNX1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000295">
        <property type="entry name" value="Ras-related protein Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF4">
        <property type="entry name" value="RAS-RELATED PROTEIN RABG3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO97063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23102" checksum="47F6CD09832EBC72" modified="2014-10-01" version="1">MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNVMKSFDNLNNWREEFLIQASPSDPDNFPFVVLGNKIDVDGGNSRVVSEKKARAWCASKGNIPYFETSAKDGTNVEEAFQCIAKNALKSEEEEEIYLPDTIDVASSSQQRSSGCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPH1</accession>
    <name>A0A068TPH1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DWD hypersensitive to UV-B 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00014520001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPH1"/>
    <dbReference type="FunCoup" id="A0A068TPH1">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPH1"/>
    <dbReference type="Gramene" id="CDO97248">
        <property type="protein sequence ID" value="CDO97248"/>
        <property type="gene ID" value="GSCOC_T00014520001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPH1"/>
    <dbReference type="OMA" id="YMINSLP"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPH1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046377">
        <property type="entry name" value="DHU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048514">
        <property type="entry name" value="DHU1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47201">
        <property type="entry name" value="BNAC09G30780D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47201:SF1">
        <property type="entry name" value="PROTEIN DWD HYPERSENSITIVE TO UV-B 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20919">
        <property type="entry name" value="DHU1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DWD hypersensitive to UV-B 1 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DWD hypersensitive to UV-B 1 N-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="606"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="810" mass="91556" checksum="288877969FD426C4" modified="2014-10-01" version="1">MATIDIHTLERRYLDSCDRHGIVPTNVVLSALFKAKVRKARSEVVSLVILLDDLTDDHFHPLLDLLSGIDFSEIEAVDFINKSSGFLSGECVLSLMRAIHKKLRVVDLQDKLFGKEFLLDLAQRGLRCQVLYLKSSHFRKLNMVGKFVHMHTLNLDFSASLTSFREDCFSCMPNLKFLSLCETRISNLWTTSAALAKLPSLTRLRFQNCLCLDESGRCCVSSQGKANESNDSGYIHGRFYSEEPWSIDEEILYQSANAEEQGMNTNDINFDQSTVEYSSDNSEVDFSSHHQDRCLPHFLPDASGWGELFDLQNQNSLGLWDIQDEVPLPSSSNSKHMPCSASRKFNSCHSSPICYEKYYREYMIASLQNLKNLDNLPIEKIDRERAKAVFSEHFEYQPYKRQNKENVVRILYKREIRATHTQAGSSREKLSYSSCDSPSYYSRSLSAAKMGSSAWPALHPLSWLGNPLRDERRSFRPRQFEYHPSDSSLMVFGTLDGEVVVVNHESENIVSYMPSLGIMNSVLGLCWLKKYPSKLVAGSDNGSLRLYEINHMSQASVGSGSVAFDDFDQLTSVHVNSADELLLASGYSKHVALYDISTGRRLQMLTDLHREHINVVKFSNHSPSIFATSSFDQDVKMWDLRQKPNQPCYSTSSSRGNVMVCFSPDDQYLLVSAVDNEVKQLLAVDGRLHLDFRISSTGSSQNYTRSYYMNGRDYVISGSCDESVVRICCAQTGRRLRDISLEGKGSGASMFVQSLRGDPFRDFNMSVLAAYVRPSSNSEIVKVNLLASNDYFEKVHLYSRFSHPLHGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPJ7</accession>
    <name>A0A068TPJ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022172001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPJ7"/>
    <dbReference type="STRING" id="49390.A0A068TPJ7"/>
    <dbReference type="Gramene" id="CDO98166">
        <property type="protein sequence ID" value="CDO98166"/>
        <property type="gene ID" value="GSCOC_T00022172001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPJ7"/>
    <dbReference type="OMA" id="AQQYNPF"/>
    <dbReference type="OrthoDB" id="440455at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPJ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31245:SF20">
        <property type="entry name" value="F18B13.13 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31245">
        <property type="entry name" value="UBIQUITIN SYSTEM COMPONENT CUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="271" mass="30283" checksum="FF4D93DF641DA20C" modified="2014-10-01" version="1">MSAIVCGKRSFFDDLQSPSPTASSPPAAKKHRCISSASPVRFLHSPPQQPPLIDRLMAAFPDMEKELLEKALEEFGHDLDSAIKSLNKLRLGYVEGELHSVVEAHARGKNGISSSDEGVSVAPEDASTQSNIPVDGAEWVELFVREMMSATSIDDARSRASRVLESLERSISARVGAEAAESFTKENTMLKEQIEVFLRENSILKRAVAIQHERQKEYDDRNQEVQQLKQLVAQYQQQLRTLEVNNYALTMHLRQAQQGNSIPGRFHPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPV1</accession>
    <name>A0A068TPV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF632 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00022032001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPV1"/>
    <dbReference type="FunCoup" id="A0A068TPV1">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPV1"/>
    <dbReference type="Gramene" id="CDO98057">
        <property type="protein sequence ID" value="CDO98057"/>
        <property type="gene ID" value="GSCOC_T00022032001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPV1"/>
    <dbReference type="OMA" id="HHHERTF"/>
    <dbReference type="OrthoDB" id="674656at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPV1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF59">
        <property type="entry name" value="PROTEIN, PUTATIVE_ 48652-45869-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="3">
        <location>
            <begin position="313"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO98057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="85130" checksum="B13B0EFEBD306476" modified="2014-10-01" version="1">MGCNQSRIENEETVTRCKERKQYMKDAVAARNAFAAAHSAYAMALKNTGAALSDYAHGEVQYPSSPSSSVHGGPASLPQPPVDHLPPPPPPLPPFHQPPPPPIQRAASMPEMSFPKRDLKHSDPILEEENEDEMETESNHGGLKHRSSKSSGGVGSRSGIGRSSEVVDDEELRNPPSPPRPSPPSPPLKQNRSPPPPPPPPEHKGMTSWDFFVLPMENVPGPTLAEVDEGRVEREELERKVLEERAKRSEIDAEGGIGWRSAGGKAESVEEVEKAPELPPQPPQVAPPPKVAKRVKQIVPADAKRRGGSSVNLLQIFSELDDCFLKASESAHEVSKMLEAARLHYHSNFADNRGHIDHSARVMRVITWNRSFRGSSNVDDVKDDFDSEEHETHATVLDKMLAWEKKLYDEVKAGEQMKLEYQRKVTSLTKLKKRDSNTEALERMKAAVSHLHTRYIVDMQSMDSTVSEINRLRDDQLYPKLVALVDGMAFMWESMRGHHESQSKIVQALSSLHISQFPKETSEHHHERTFQLLLVVKEWHMQFDKLIKNQLDYIRALNNWLKLNLIPIDTNLKEKVSSPQRPANPPICVLLHAWHDYLEKAPDELARSAINNFAHVVDHIVEYQIDEMKLRNKCEDTRRELAKKTEQFKDWYRKYMQRRTPPDELDPERAQDKDLIVERQIQVETLEKKLEEEEAEYKKQCIQVREKSLASLRTGLPNLFLAMSGFSLACSDMYRNLRSISQKRSRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQD3</accession>
    <name>A0A068TQD3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MLO</name>
        <name evidence="11" type="ORF">GSCOC_T00014960001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in modulation of pathogen defense and leaf cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MLO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQD3"/>
    <dbReference type="FunCoup" id="A0A068TQD3">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQD3"/>
    <dbReference type="Gramene" id="CDO97578">
        <property type="protein sequence ID" value="CDO97578"/>
        <property type="gene ID" value="GSCOC_T00014960001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQD3"/>
    <dbReference type="OMA" id="IWSLWGL"/>
    <dbReference type="OrthoDB" id="1388414at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF9">
        <property type="entry name" value="MLO-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4 8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO97578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="562" mass="64213" checksum="D1F79A9F10F287B2" modified="2014-10-01" version="1">MHELIREGRSLEFTPTWSVASVTTVMVFVCLFVERSIYRFGKWLRKTRRKALFASLEKIKEELMLLGLISLLLGQWARWISQICVKSSLFSSKFYLCSDEDYGMGERERVLFTKSDTFSNETEIPTGLNYSTLHQCGADREPFVSHEGLEQLHRFLFVLGFIHVIYSCITVGLAMSKIYSWRKWENEATFAPDGNLQAPKNKVMRRQSTFALHHASHPWSRSRVLIWMLCFLRQFRSSIQKSDYLALRLGFITNHSLPLSYNFHKYMVRSMEDEFSGIVGISWPLWGYAIICIFINIHGLNVYFWLSFIPAILVMLVGTKLQHVVSLLALEIAEPKGSSFGTLVKPRDELFWFGKPEILLRLIQFISFQNAFEMATFIWSLWAFKQRCFMKNHALIAIRLISGIVVQAWCSYSTVPLNVIVTQMGSRHKKALIAESVRESLHSWCKRVKERARRDAALSLATRSTCSLESTIDEGDEIITVASGTLSPCSSSGSLNHQDMNEESTDCVVEGSNPPDDDISFRISEYLAQTIASGAGAGDNADDLEEHHQHQPETLFDLFQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQH1</accession>
    <name>A0A068TQH1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022283001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQH1"/>
    <dbReference type="STRING" id="49390.A0A068TQH1"/>
    <dbReference type="Gramene" id="CDO98252">
        <property type="protein sequence ID" value="CDO98252"/>
        <property type="gene ID" value="GSCOC_T00022283001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQH1"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4370:FF:000002">
        <property type="entry name" value="Transcription factor TFIIIC, tau55-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="253" mass="28555" checksum="8EA565FEA764D090" modified="2014-10-01" version="1">MFILTKQKKKSYLIKIFETAFFSIVSRPKKPHPHQRPSQPLFYPIPRGARVGDGTIPGSSHPITRLFPSLLFSLPSSVRGFGFWGFGFGSFINLKIKLMMEGNNIRWHQDDKREEEVEEEEYVLINLDAVTDLVNIPPNAPYVLSGLDTLNPTLIIDEKFRLIGEYEETIGTCLVFSECDAAPELHQETGPSEANLFTGRCIVDNKRAPTKQVKPITQLHKILKFRLAQEADIGDSTAKQTNIVNNENSNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQJ0</accession>
    <name>A0A068TQJ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022324001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        <property type="gene ID" value="GSCOC_T00022324001"/>
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    <dbReference type="OMA" id="VNIPRFC"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fer2"/>
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    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
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    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11661" checksum="28080E060CFC07EA" modified="2014-10-01" version="1">MGLGLLASRTLLRSEKLRPGNFTLLLCRSIISTIHFPNPEDAIEVFIDGYPVKIPKGMTVLQVNIPRFCYHSRLSIAGNCRMCLVEVEKFAKPIASCAMLALLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQU9</accession>
    <name>A0A068TQU9_COFCA</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CDO98417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="191334at2759"/>
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        <property type="component" value="Chromosome VI"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="BC10-like"/>
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    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042">
        <property type="entry name" value="CORE-2/I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042:SF153">
        <property type="entry name" value="GLYCOSYLTRANSFERASE BC10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO98417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="405" mass="47040" checksum="5DBE6F055B1D9BA7" modified="2014-10-01" version="1">MKQGHQQQQQQQQQQLQISNLFSFQRYLHNLVLYFMFFGTGLVIGVSLSFYLAENPFNLQFKLFSTSQSTLPLPPPPPPSPSPPPPPPPVLCPAPAPVPDFTTPKNLTHQMTDEQLLWRASMVPRINEYPFKRTPKVAFMFLVRGELPLARLWERFFKGHEGLYSIYIHSSPSYNGTTPDGSVFHGRNIPSKDVEWGKVNMIEAERRLLANALLDFSNQRFVLLSESCIPLFNFSTIYSYLINSTETFVDSYDLPGPTGQGRYNKKMKPVINKSDWRKGAQWFEMDRELAIQVVSDRIYFPLFKRHCKSSCYADEHYLPTFVGMKYGRKNSDRTLTWVDWSKGGAHPHRFSRYEITPDFLNRMRNGQTCEYNGRKTNICHLFARKFSWTALDRLLMYAPKVMEFN</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
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            <taxon>Gentianales</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
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                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Librado P."/>
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                <person name="Munoz A."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
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                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
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                <person name="Graziosi G."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="7272" checksum="B26D05AD70DB5981" modified="2014-10-01" version="1">MTGNGKFYYNKKLPLDPFGQSFWPKIASFSGLYFFIIIFYLYISNCYNNFSKKKIAIQTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRG0</accession>
    <name>A0A068TRG0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022666001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRG0"/>
    <dbReference type="Gramene" id="CDO98534">
        <property type="protein sequence ID" value="CDO98534"/>
        <property type="gene ID" value="GSCOC_T00022666001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRG0"/>
    <dbReference type="OMA" id="KEIMGHD"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRG0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF242">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 89B2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52483" checksum="DE60126342524532" modified="2014-10-01" version="1">MSISPNQSPHVLLFPYPTAGHVIPLLDLANLLLTKGLTITILVTPPNLPLLDPLLSTHPSTSIQRLVLSLPELVNSSGVNFATRLRATAQLHDTVLEWFQSQQSPPVAIISDFFLGWTHHLAAQLGVPRVVFWPSGAHHALILHHLWHNLSEKISSMNEDSMISFPSLPNSPAYPLWQVAELITQSKPGEPDWEFFRDNFLSNARSWGIIINSFRDLEDTCINLVKTEICHDEVWAIGPLVLSSSASTAAATGDTSALSNRGGSSAVPLDEVMTWLDDKADDSVVYVCFGSREVLTSQQTDALAAALECSGVHFIWCAREAQQNKGQVSCDDQTSALLTMEYEDRVAGKGLIIRGWAPQVAILQHRAVGAFLTHCGWNSVLEGVAAGVVLLTWPIGADQFANAGLLVDELGLAIPACLGGPKVVPDSTKLAQVFVGSVSVDGQPKRAKVVEMRDAASRAVQNGGSSSKDLDDLVKHLRDLKQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRM4</accession>
    <name>A0A068TRM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BI1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025954001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRM4"/>
    <dbReference type="FunCoup" id="A0A068TRM4">
        <property type="interactions" value="2828"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRM4"/>
    <dbReference type="Gramene" id="CDO98965">
        <property type="protein sequence ID" value="CDO98965"/>
        <property type="gene ID" value="GSCOC_T00025954001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRM4"/>
    <dbReference type="OMA" id="FTGWYVY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO98965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27258" checksum="CA67619F217D774B" modified="2014-10-01" version="1">MDLYGAKSTKDDYAVDLEAGDLLYPGIGYGENQLRWGFIRKVYGILAAQIVLTTLVSALIVLYDPINQLLRGNSILLLFLCFLPFVLLWPLHVYQQKHPLNLVFLGLFTASLSLTVGVSCANTDGRIVLEALILTSAVVVGLTGYTFWAAKKGKDFSFLGPILFTSLVVLLLTSFLQMFFPLGSTSTAVFSAFGAIVFSGYVVYDTENLIKRFTYDEYIWASVNLYLDILNLFLTILQMLRQGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTK3</accession>
    <name>A0A068TTK3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00026365001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTK3"/>
    <dbReference type="Gramene" id="CDO99274">
        <property type="protein sequence ID" value="CDO99274"/>
        <property type="gene ID" value="GSCOC_T00026365001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTK3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO99274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="71" mass="7798" checksum="15BE27DB12DADED3" modified="2014-10-01" version="1">MPPVLPQLNCHHPEHYSPLISSILSIIFSGVSPVSFPSSAIPFSRFFQHAGRLEVSCLKSNSGKHEQIQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTU5</accession>
    <name>A0A068TTU5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00025665001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTU5"/>
    <dbReference type="STRING" id="49390.A0A068TTU5"/>
    <dbReference type="Gramene" id="CDO98753">
        <property type="protein sequence ID" value="CDO98753"/>
        <property type="gene ID" value="GSCOC_T00025665001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTU5"/>
    <dbReference type="OMA" id="HGTMMIN"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF19">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="51"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO98753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="342" mass="38213" checksum="44DFED132FF24C79" modified="2014-10-01" version="1">MAPGDNKVAANTIVFPQFDILSGDSAHSDHYFIHSNKSKKAQGCFNDSTSAVSKKIAKEWKILEKDLPDSIYVRVYEQRIDLLRAVIIGAAGTPYHDGLFFLDIVLPSDYPNQPPKVYYHAHGLCLNPNLYSNGTVCLSLIHTWTGRGVELWTPAKSTILQLLVSVQGLVLNSKPYFNEPGREVGLYSKAERWTKKSMAYNEEVFISSCKTMLYNLRKAPKGFESFVVEHFRARGDFILAAIRAYINGDATVGQYQECVSASLSSVPVSSKFKANLEKMHLDLRSAFHGIDTSPPKMKKLPLEGRREEKEATSDAVKSRSSAKESKQGISSRILKVLKKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUF4</accession>
    <name>A0A068TUF4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00029652001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUF4"/>
    <dbReference type="FunCoup" id="A0A068TUF4">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUF4"/>
    <dbReference type="Gramene" id="CDO99930">
        <property type="protein sequence ID" value="CDO99930"/>
        <property type="gene ID" value="GSCOC_T00029652001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUF4"/>
    <dbReference type="OMA" id="WWDKKPI"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUF4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO99930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26905" checksum="5A9827EEB5E4DDF3" modified="2014-10-01" version="1">MHSSYISRTHNFLYSRKYNFRFSYPNYCTTTTTSERATMEKYSKDAVGEEVIKDQLREGFAKSACDYDPSNREFDEILPHLLNIYASHATPQDFDIYAPDATFEDPLMRAQGIKQIKSAFYSIPKVFSESRITEYSIKENVISPRKKEILMDNKQYYKFLGKDIHMISLIKLQIENGKIVRHEDWWDQKPLWNSETVRLPLVGRLAEMTRRASMLVTHCLMRFGKDPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVQ3</accession>
    <name>A0A068TVQ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PsbP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00029799001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVQ3"/>
    <dbReference type="FunCoup" id="A0A068TVQ3">
        <property type="interactions" value="940"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVQ3"/>
    <dbReference type="Gramene" id="CDP00039">
        <property type="protein sequence ID" value="CDP00039"/>
        <property type="gene ID" value="GSCOC_T00029799001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVQ3"/>
    <dbReference type="OMA" id="IHELGPM"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
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    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
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        <property type="entry name" value="PsbP_C"/>
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    <dbReference type="NCBIfam" id="NF040946">
        <property type="entry name" value="PSII_PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31407">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31407:SF10">
        <property type="entry name" value="PHOTOSYNTHETIC NDH SUBUNIT OF LUMENAL LOCATION 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01789">
        <property type="entry name" value="PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PsbP C-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="239" mass="26782" checksum="7429B11CDC9836A7" modified="2014-10-01" version="1">MAVSSMSLSLASTTTTALTKGFHVPPSKGIISARPTPFCTLSFITCSRDTIPEEERNCLRRSLLLGVGVLSLNLSSAAALLAQGIPKNYEAFVDKADGYSYFYPSDWRDFDFRGHDSAFKDRYLQLQNVRLSFIPTDKSDVHDLGPLDEVVSHLVNHVYSAPTQVATVMDMQEKNIEGRNYYTFEYVLTSSNFARAAFATIAIGNGRYYTLIVGANERRWRRVRNQLKVVADSFKLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVX9</accession>
    <name>A0A068TVX9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00032351001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 6"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVX9"/>
    <dbReference type="STRING" id="49390.A0A068TVX9"/>
    <dbReference type="Gramene" id="CDP00416">
        <property type="protein sequence ID" value="CDP00416"/>
        <property type="gene ID" value="GSCOC_T00032351001"/>
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    <dbReference type="InParanoid" id="A0A068TVX9"/>
    <dbReference type="OMA" id="LFMGFTE"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVX9"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000089">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF53">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="328"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="480" mass="52890" checksum="342360246C244AAF" modified="2014-10-01" version="1">MVKICCIGAGYVGGPTMAVIALKCPSIEVAVVDISQPRISAWNSDHLPIYEPGLDDVVKQCRGKNLFFSNDVEKHVAEADIVFVSVNTPTKSQGLGAGKAADLTYWESAARMIADVSKSAKIVVEKSTVPVKTAEAIEKILTHNSKGINFQILSNPEFLAEGTAIQDLFDPDRVLIGGRETPEGLKAVQTLKEVYAHWVPEERIICSNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVSQVSHAVGKDTRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKHVIKINDYQKARFVNRIVSSMFNTVSGKKIGILGFAFKKDTGDTRETPAIDVCRGLLVDKAQLSIYDPQVSQDQMQKDLTMVKFDWEHPVLLKPASPTALKQVSFAWDAYEASKDAHGICFLTEWDEFKTLDFQKIYDNMQKPAFVFDGRNVVNPDKLRQIGFIVYSIGKPLDQWLKDMPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW57</accession>
    <name>A0A068TW57_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029218001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW57"/>
    <dbReference type="STRING" id="49390.A0A068TW57"/>
    <dbReference type="Gramene" id="CDO99583">
        <property type="protein sequence ID" value="CDO99583"/>
        <property type="gene ID" value="GSCOC_T00029218001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW57"/>
    <dbReference type="OMA" id="CENAKPI"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW57"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="311" mass="35305" checksum="E3423654BA141DF5" modified="2014-10-01" version="1">MEKIEHKYVEVNGLKLHVAEIGNGSKTVLFCHGFPEIWYSWRHQMVAVASAGFRALAPDYRGYGFSDPPPVPEKANYLDFVSDLHALIQCLGIPKVFLVAKDFGVRVAQVFALLHPEKVEGVVTLGAPFTPLGPPLFLQYLPGGFYISRWQEPGRAEADFGRFDPKTVVRRIYILFSRSELPIAGENQEIMDLVDSSMPLPSWFTEKDLEMYGSLYDKSGFRTALKVPYRSLSEEFNISEMKVDVPALLIMGEKDYVINFPGMNDYIRTEQAKECVPQLETKYIPEGSHFVQEQFPDQANDLILNFLKQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXP5</accession>
    <name>A0A068TXP5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029917001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXP5"/>
    <dbReference type="FunCoup" id="A0A068TXP5">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXP5"/>
    <dbReference type="Gramene" id="CDP00118">
        <property type="protein sequence ID" value="CDP00118"/>
        <property type="gene ID" value="GSCOC_T00029917001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXP5"/>
    <dbReference type="OMA" id="IVRHAKP"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXP5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000028">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF412">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP20-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="188" mass="20281" checksum="E0481B8A3ECB2EBD" modified="2014-10-01" version="1">MSDTIDLTGDGGVLKTIVRHAKPDAIAPSESLPLVDVHYEGILADTGEVFDTTREDNTVFTFEVGKGSVIKAWDVALRTMKVGEVAKITCMPEYAYGSAGSPPEVPPDAILIFEVELVTCRPRRGASLSSVSDERARLEELKKQREVAAATKEEEKKRREEAKAAAAARIQAKLEAKKGQGKGKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXU7</accession>
    <name>A0A068TXU7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00032021001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXU7"/>
    <dbReference type="Gramene" id="CDP00163">
        <property type="protein sequence ID" value="CDP00163"/>
        <property type="gene ID" value="GSCOC_T00032021001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP00163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="57" mass="6632" checksum="7C37CF8E664CE9B9" modified="2014-10-01" version="1">MAEKFRKFMGLCCSRKPVVISCQKQIILELEEEIESQSMGKKNSTKLLYIYTPSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYB3</accession>
    <name>A0A068TYB3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034379001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYB3"/>
    <dbReference type="FunCoup" id="A0A068TYB3">
        <property type="interactions" value="3265"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYB3"/>
    <dbReference type="Gramene" id="CDP00924">
        <property type="protein sequence ID" value="CDP00924"/>
        <property type="gene ID" value="GSCOC_T00034379001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYB3"/>
    <dbReference type="OMA" id="PVHYNET"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYB3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37081" checksum="B1DDB981791C72C2" modified="2014-10-01" version="1">MEEADASVDNNARISKEAPQLVAVLREMKYGLDTVRAKIEALAAKVKADNFPTTDGISYLDAKYLLLLNYCQSLVYYLLRKAKGLSIEGHPVVRSLVEIRLFLEKVRPIDKKLQYQIGKLAGVTPRNVAENRDMTVEETETAKEEEKWIKYRPNPDMLISKTDATLEKDGVYRPPKLVPATMDEDKMSRQERNAMRKEKETLRQARRSAYVRELMNDLEGKPEEVREDIGTESAEVTKYMEKMEQRAQQEEELFIRAPLTKAEKKKMRRLKKPRNGLLDLTESFYDEIKTLPLEDNGPEQSAVIGNGNSSERKFKKQKRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYF0</accession>
    <name>A0A068TYF0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-acyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00032309001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYF0"/>
    <dbReference type="FunCoup" id="A0A068TYF0">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYF0"/>
    <dbReference type="Gramene" id="CDP00383">
        <property type="protein sequence ID" value="CDP00383"/>
        <property type="gene ID" value="GSCOC_T00032309001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYF0"/>
    <dbReference type="OMA" id="ICCFIEK"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYF0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF265">
        <property type="entry name" value="PROTEIN S-ACYLTRANSFERASE 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="177"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="626" mass="69178" checksum="191BE3A3928A6990" modified="2014-10-01" version="1">MRKHGWQLPYHPLQVVAVAVFLALGFAFYVFFAPFVGRKLYQYIVMGLYTPLIVSAFSLYIWCAAADPADPGVFKSKKYLKIQEKPLQQKQSKLGGDSTSSIQDAKAATTGDKTFDEANKEVEAKAEHAAQMEKNASPNQRGHLMALLTFLPCAFLCKCSSSHEESSEHQTSEDGMFYCSLCEVEVFKYSKHCRVCDKCVDRFDHHCRWLNNCIGKRNYRKFFILMVSALLLLILQWSTGILVLICCFLERKRFSVDITTKLGSSFTVVPFIIVVAVCTILAMIATLPLAQLFFFHILLIKKASGISTYDYIIALREQEQQGIGGQQSPQMSPVSSLTGLSSASSFNNFHRAAWCTPPRLFVEDQFDVVPPETGSVSSLGKKSVVEEPIKKKNPVPVKISPWTLARLNAEEVSKAAAEARKKSKILQPVTRHEAQYTPETDSSFGSSGRRMVSRPDNSRKRPSKRVRLPADLPVEPLTRNSSEAAGISMRHMITDTSTSLAPLHLEAPSAFRTGRTISTSAGIVASSPESSLDSPDIHPFGASLGTEEARRLVGLSAASINVQKDIPLSRSTSDGYDASGGEDSDRVPHRIGQRPSNWSSLLFGTDPDDRVTRLNFSSSSRSDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZQ9</accession>
    <name>A0A068TZQ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ethylene insensitive 3-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00036474001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZQ9"/>
    <dbReference type="FunCoup" id="A0A068TZQ9">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZQ9"/>
    <dbReference type="Gramene" id="CDP01429">
        <property type="protein sequence ID" value="CDP01429"/>
        <property type="gene ID" value="GSCOC_T00036474001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZQ9"/>
    <dbReference type="OMA" id="YACQNTM"/>
    <dbReference type="OrthoDB" id="2017676at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZQ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3180.10:FF:000001">
        <property type="entry name" value="Ethylene insensitive 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3180.10">
        <property type="entry name" value="DNA-binding domain of EIN3-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006957">
        <property type="entry name" value="EIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047091">
        <property type="entry name" value="EIN3-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023278">
        <property type="entry name" value="Ethylene_insens-like_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33305">
        <property type="entry name" value="ETHYLENE INSENSITIVE 3-LIKE 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33305:SF29">
        <property type="entry name" value="ETHYLENE INSENSITIVE 3-LIKE 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04873">
        <property type="entry name" value="EIN3_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding domain of EIN3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ethylene insensitive 3-like DNA-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="365" mass="41142" checksum="BAC2E5AA6389FF77" modified="2014-10-01" version="1">MSRAQDSILKSMVKIMEVCNAQGFVYGIVPEKGKAMTGSSDSLREWWKGKVKFDQMAPVAIAEFLPKIIQEGGVDPNSLLYLLQGIPDTILGSLLSALMQHCAPPQRRFPLENGLPPPWWPTGKELWWGDQGMAQEQGAPPYKKPHDLKKAWKVSVLASVIKHMAPDFNRLRRLVRQSKCLQDKMTAGDTSTWSRIVDQEEALSKLTEKALKISPSEQDDQEKEKEEGLNLASVAASEKRKCMFECEVILDSLLACQNSDCPQSNLSSGFSDKNSRSEHEKTCIYRKSDGEKNDADIKSQESNSFPVGLSIHHQPFPEGQVLFTADQVMVNDDHHGVTSQHDWMDTYHDEIGQLPWIMMHMETWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1X8</accession>
    <name>A0A068U1X8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00039960001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1X8"/>
    <dbReference type="Gramene" id="CDP02545">
        <property type="protein sequence ID" value="CDP02545"/>
        <property type="gene ID" value="GSCOC_T00039960001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1X8"/>
    <dbReference type="OMA" id="VESQCCH"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1X8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000218">
        <property type="entry name" value="WD40 repeat-containing protein HOS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP02545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62396" checksum="4F18AB1821A3A6A8" modified="2014-10-01" version="1">MASITSVELNYLIFRYLQESGFTHSAFAFGYEACINKCQIDGSLVPPGALVTFVQKGLQYLEMEANLSNADSDVDEDFSFLQPLDLITKDVYELRRTIKERRKNELKKTKEKELDKQYEEAHGLVKDREKQVRKREREKETERTEEKPREKEHSYHNDKEVDTNHEDQKNVRNEENGVSGEPMEISTTSTSQIVELTSCDVTILEGHTSEVCACAWSPSGSLLASGSGDSTARIWRIGDGTNQSSSQNGPAGEIVLLHVKAKTNEKSKDVTAIDWNIDGTLLATGSYDGQARIWSTDGELKSTLTRHKGPIFSLKWNKKCDYIVTGSCDKTAVVWDVKTEGFKQQFEFHSGPILDVDWRNNVSFATSSTDHMIYVCKIGETSPIKTFSDHQGEVNCLKWDPTGTLLASCSDDVTAKIWSLKQDKCVHDFKEHDKEIYTIRWSPTGPGTNNPNLPLLLASASFDSTVKLWDVEQGRLLCSLTGHREPVYSVAFSPNGEYLASGSLDKSVLIWSLKESKIIKRYTGNGGIFEVCWNKEGDKIAACFANNVVCVLDFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U297</accession>
    <name>A0A068U297_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00039644001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U297"/>
    <dbReference type="FunCoup" id="A0A068U297">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U297"/>
    <dbReference type="Gramene" id="CDP02289">
        <property type="protein sequence ID" value="CDP02289"/>
        <property type="gene ID" value="GSCOC_T00039644001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U297"/>
    <dbReference type="OMA" id="GLMQDWP"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U297"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106286">
        <property type="term" value="F:(E)-caffeate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050563">
        <property type="term" value="F:trans-feruloyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05904">
        <property type="entry name" value="4CL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF389">
        <property type="entry name" value="4-COUMARATE--COA LIGASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="459"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP02289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="547" mass="59518" checksum="8903B8917B20F991" modified="2014-10-01" version="1">MGSTGIQSLHPEEHVFRSRYPPVQIPSDLTLPDFVLQNAELYSEKVAFVDAATGKGYTYAEVARDIRRFAKALRSIGLRKGCVVVVVLPNVIEYAIIALGIMSAGGVFSGANPASHASEIKKQVESAEAKLIITDASTYKKVNDLGLSVIVVGEEERIEGTMKWDELLEAADRASSGSNNETVQQSDLCALPFSSGTTGLSKGVMLTHRNIVANLCSSLFSVGPEMIGQVTILGLIPFYHIYGLTGICCATIRNKGKVVVMPKYELRAFMDALITHEVTFAPIVPPIILGLVKNPIVDEFDLTKLKLRSIMTAAAPLAPEILNEFEKKFPGIVVQEASIAYGMTEHSCITISHGDPSKGHGIAKRNSVGFILPNLEVKFVDPETGRSLPKNTPGEICVRSQCVMKGYYKNEHETALTIDKDGWLHTGDVGYIDDDGDVFVVDRIKELIKYKGFQVAPAELEGVLLTHPSVEDAAVVGLPDKEAGEIPSAWVVISPGAKENEEDIIKHVAANVAHYKKVRRLQFVDAIPKSPSGKIMRRLIKEKMAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2K7</accession>
    <name>A0A068U2K7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037016001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2K7"/>
    <dbReference type="STRING" id="49390.A0A068U2K7"/>
    <dbReference type="Gramene" id="CDP01843">
        <property type="protein sequence ID" value="CDP01843"/>
        <property type="gene ID" value="GSCOC_T00037016001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2K7"/>
    <dbReference type="OrthoDB" id="1932217at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33872">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33872:SF7">
        <property type="entry name" value="OSJNBA0084K11.10-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="278" mass="32117" checksum="5B6659442AE86542" modified="2014-10-01" version="1">MDLFEDADRLRNDDGSTLLKYVQRVIKIDTSISMLLMFTLRGAVSFIFRQTMIKLKAFEVQFPTWFPASIRCPAFECLLWTGRLLTSNRTQMRCFVFEIFKMMQIETKSETHSSRLKMGSSPPPPPPVPPLPKFSCTANPAIKRPTVVSVTNQEIAMYWRQRSMVEEDHLLAAIKAAARIRARNLSEDDYRRFEESLKEDDDGKEKDTAAESFSQKDEKIKELRVGIKDWWTKSKYAYLNQPVIESMDTPKRRASAYIPQFCCYMSAPPPATRNLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3C1</accession>
    <name>A0A068U3C1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041467001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3C1"/>
    <dbReference type="STRING" id="49390.A0A068U3C1"/>
    <dbReference type="Gramene" id="CDP03006">
        <property type="protein sequence ID" value="CDP03006"/>
        <property type="gene ID" value="GSCOC_T00041467001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3C1"/>
    <dbReference type="OMA" id="ISYFDFQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3C1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000327">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000560">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052059">
        <property type="entry name" value="CR_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47973">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="101"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="447" mass="50241" checksum="B986422032C1B2B2" modified="2014-10-01" version="1">MERCFYFLDAVTSATPPMLDLQSPIKHSSSALFFLLGGMVVLIILLVLFFIYNKFIKTGRLKMFTAGPKKGLCGTTNVLSGNLHTISYYDFETLKKATKNFHHANLLGRGGFGPVFLGKLEDGKLIAVKQLSLEKSQQGESEFLSEVRMITSIQHKNLVRLLGCCSDGAQRLLVYEYMKNRSLDIIIYGKSDVFLNWSTRFQIIIGVARGLQYLHEDSHFRIVHRDIKASNILLDDKFQPRIGDFGLARFFPEDQAYLSTTFAGTLGYTAPEYAIRGELSEKADIYSFGVLVLEIISCRKNTDLALPSEKQYLPEYAWKLYEKSKLMDLVDPKLREDGVLEKDVLQVLHLAFLCLQPHANLRPPMSEVVAMLTCKVELDEAPIRPAFLDRKRRNNDPASWDTISEVFPSPQRSSSNSFPKPGIPPASSPKQINPTTLPKSASISLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4K3</accession>
    <name>A0A068U4K3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039958001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4K3"/>
    <dbReference type="STRING" id="49390.A0A068U4K3"/>
    <dbReference type="Gramene" id="CDP02543">
        <property type="protein sequence ID" value="CDP02543"/>
        <property type="gene ID" value="GSCOC_T00039958001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4K3"/>
    <dbReference type="OMA" id="HEDGNTN"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4K3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF59">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654535" description="Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18042" checksum="D324E466D588D777" modified="2014-10-01" version="1">MPSINSAAYSFVVVLLEVLCARPAIDNSLPRQQVNLAGWGMSCLMKGELHKIVDPLLAFIERRYGETVEKCLKECAVNRPNMVEVLWDLECALQLQHSAIPEQSHEDGNTNISYNLPLPVIRGLPSHSIAISEDEMGSGTHSTKVAQILDSEVLSQLWMDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5W1</accession>
    <name>A0A068U5W1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00016388001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5W1"/>
    <dbReference type="FunCoup" id="A0A068U5W1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP03886">
        <property type="protein sequence ID" value="CDP03886"/>
        <property type="gene ID" value="GSCOC_T00016388001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5W1"/>
    <dbReference type="OMA" id="RPQTDRN"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5W1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46629">
        <property type="entry name" value="OS01G0917900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="281" mass="30814" checksum="8F216B2FE21D7537" modified="2014-10-01" version="1">MSNLTLSAVLKTEDRSGGPMRTPSNRTLMDIIREDPNGGGYSKDTRKSWRHFREKLRLRRQGSGSSWTSSVPVPASDVPIQHPMGGSSSSRRMMMSRRDSTRLNTPTPDQTSQPDADLSSGVPRSRSSMLQRNESRAIRGRYDNARGIDDEMGAEEGEETEGETTEEEEGGGGGTGGGEEQPVRMSLMALLAETDRQMGLDGSGFTMDDDEDADEEEEEEEEGGAGGGGYNNCCVCMVRHKGAAFIPCGHTFCRLCSRELWVQRGNCPLCNNFILEILDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U690</accession>
    <name>A0A068U690_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00016298001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP03812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U690"/>
    <dbReference type="STRING" id="49390.A0A068U690"/>
    <dbReference type="Gramene" id="CDP03812">
        <property type="protein sequence ID" value="CDP03812"/>
        <property type="gene ID" value="GSCOC_T00016298001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U690"/>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U690"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="764" mass="83752" checksum="D5424160279618BE" modified="2014-10-01" version="1">MTAQSWLDDRGSLSHTQSQTPRSAGNVFRLLARREICPRTKCLPKKHWGEATKQNCYSPFGIRSEAKRDARRGLSSWMEAESLEHLSAKYCSLVPPPRSTIAAAFSPDGKSLASTHGDHTVKIIDSESGQCLKVLRGHRRTPWVVRFHPKDREILASGSLDHEVHVWNANTSECIGYRDFCRPIASLAFHAEGELLAVASGHKLYLWSYNGSGENSSPTILLKTRRSLRAVHFHPHAAPLLLTAEVNDLDSSNSSMSRATSLSCLQYPPPSLHMANINSRNLLNVAAELSLVPSFNPYPSSSAIDDIEINARLVEQNDQRAFPVDMYATTSTTHTGLQDRLISSFAYREQNSISGTAVDAMDTAEMQHIEGYHPRGPSDQETPGPGVRPLPSISHTLELPIPIPRQVESSRFGQNGSLPSRQSSPWDLPFLQGWLIGQSQAGIHPRLPVSSHMYPVGYPGIHEVSLTSNSFICNRVLPSIMSRSVEAESSGLQQQPQLTENRILNSLRRVDSIPILGVIPSELSASFSTTVGAELPCTVKLRLWLHDIKNPCAPLDTDKCSLTIPLAVLCSEMGAHFSPCGRYLAACVACVLPKVDAEPSSVSQLNQDIGADGLSPTRHSSLAHQVLYELRIYSLEESTFGSVLVSRVVRAAHCLTSIQFSPMSEHILLAYGRRHSSLLKSIVMNGEVSLPVYTVLEVYRVSDLELVSVLPSAQDEVNVACFHPSVGGGLVYGTKEGKLRILQYDGAYRLNSSTSNIFPTAQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7S7</accession>
    <name>A0A068U7S7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein CHUP1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00017491001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7S7"/>
    <dbReference type="STRING" id="49390.A0A068U7S7"/>
    <dbReference type="Gramene" id="CDP04179">
        <property type="protein sequence ID" value="CDP04179"/>
        <property type="gene ID" value="GSCOC_T00017491001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7S7"/>
    <dbReference type="OMA" id="MRNCKEF"/>
    <dbReference type="OrthoDB" id="754037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7S7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072699">
        <property type="term" value="P:protein localization to cortical microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040265">
        <property type="entry name" value="CHUP1/IPGA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342:SF41">
        <property type="entry name" value="OS08G0129600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
        <property type="entry name" value="PROTEIN CHUP1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP04179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="64785" checksum="85AD9370F9B33D7C" modified="2014-10-01" version="1">MEVVELRRLNKELQLQKRSLACRLSSLESQLATSAKVSESDIVEKIKEEASLLRHTNQDLCKQVEGLQMSRLNEVEELAYLRWVNSCLRNELRNCSNLNSDTICSPYAIERPRESICLSSNGSDEDSGYSSISRLNLIKKLKKWPITDEDMQQLDHTDNFRDPNWDNSESSMRRHSISGLKCYSQDFMLDKRRQSDGFMRFKEPTKEVQMLDSQKYDLRANKLPEFLSSCQDACRVKASLDVEKRALRIPNPPPRPSCTASSTQKAQISSQVPAPPPPPPPPPPPPKFIGRNMTGTVKRAPQVVEFYHSLMKRDSRKDSLNGGTCDASDVANVRSSMIGEIENRSSYLLAIKADVETQGEFVNSLIQEVNNAMYQNIEDVVAFVKWLDDELCFLVDERAVLKHFEWPEKKADTLREAAFGFRDLKKLEHEIENYIDDPQLSCDAALRKTVALSEKMERTVYNLLGMRDLMIRRCKEFQIPTDWMLDTGILSKIKLASVKLAKVYMRRVAMELQSKGALDKESSMDYMLLQGVRFAFRIHQFAGGFDADTMHAFEELRNLSVVLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7T0</accession>
    <name>A0A068U7T0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein TIC 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00017497001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
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        <text evidence="7">Involved in protein precursor import into chloroplasts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Chloroplast inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Tic20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP04184"/>
        <property type="gene ID" value="GSCOC_T00017497001"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="414558at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7T0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005691">
        <property type="entry name" value="Tic20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510:SF5">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16166">
        <property type="entry name" value="TIC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="4" id="KW-1001">Plastid inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="206" mass="22753" checksum="7A80A412BAD873AB" modified="2014-10-01" version="1">MATLPLLRPSVLRHPNNPLHRKLHPPPPHSTHLKFPQPSKPITSTMSVSASSKTPTPAADRLMSAASYCFPLFNGFQYGRFLLSEYPILATPFKPIIPVVSAYHSIPYASFISFFAFYLGIVRNPSVSRHVRFNALQALVLDVVLVVPMMVQQILSPGLNLTILGYNCLFVFLVACFAYALGCSVLGKTPYLPFIAEAASRQLDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8A4</accession>
    <name>A0A068U8A4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00016337001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8A4"/>
    <dbReference type="FunCoup" id="A0A068U8A4">
        <property type="interactions" value="1552"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8A4"/>
    <dbReference type="Gramene" id="CDP03843">
        <property type="protein sequence ID" value="CDP03843"/>
        <property type="gene ID" value="GSCOC_T00016337001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8A4"/>
    <dbReference type="OMA" id="LGAEKCQ"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8A4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP03843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="382" mass="42583" checksum="4ABEBF48A9E2D696" modified="2014-10-01" version="1">MVINRQLVLTYLYLLVYILLSSGVILYNKWVLSPKYFNFPFPITLTMIHMGFSGLVAFFLVRVFKVVTPVKMTFEIYATCVIPISAFFASSLWFGNTAYLFISVAFIQMLKALMPVATFLMAVICGTDKLRWDIFLNMVLVSIGVVVSSYGEIHFNIVGTVYQVTGIFAEALRLVLTQVLLQKKGLTLNPITSLYYIAPCSFVFLFVPWYLLEKPGMEVSQIQFNFGIFFSNALSALALNFSIFLVIGRTSAVTIRVAGVLKDWILIALSTVVFPESTITTLNIVGYAIAICGVIMYNYLKVKDVRASQLPIENLAERTAKEFKMEKKSSDLYVPDDTINSSSGLRIGRNSASDVNVDEEAPLLASSRLSHLGQSHYSSHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8E4</accession>
    <name>A0A068U8E4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00019538001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8E4"/>
    <dbReference type="STRING" id="49390.A0A068U8E4"/>
    <dbReference type="Gramene" id="CDP04810">
        <property type="protein sequence ID" value="CDP04810"/>
        <property type="gene ID" value="GSCOC_T00019538001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8E4"/>
    <dbReference type="OMA" id="NERRHTI"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8E4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1498">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="422" mass="47557" checksum="4B27D842827531E8" modified="2014-10-01" version="1">MDSIAASNKPHAVCIPYPALSHINPILKLAKLLHHKGFYITFVNKECNDLPDFRFETIPDDMPPDADSAQDMPSLSKSTSKTCLATFSSLLSRLSKAAPDVPPVICIISDGIMSFTVKAAQQFDLPEVLFWTPSAYGMLAYMQYCHLVKQGHIPLKGTYVTNSYLGMRNLDSWNERRHTIEGSSKLHKNNCSAVVLNTFYDFEHSSLDAISAMYPHVYSTSPLQLMLNQIHDESLTSISSDLWREEPGCIEWLNDKDPKSVVYVNFGSITVITAHQLIEVAWGLANSKKSFLWIIRPDMVAGDDAAVLPLEFLTKTKERGKLELTRTSSKSSCNCRVLNTLRMELDFRKYLCRRTRYLLALFLRGEVEVLVRELMDGEKGQKMRNKALDWKNKGEAAAGPNGQSYQNLDQLIKDLLLPILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8G3</accession>
    <name>A0A068U8G3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00017894001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8G3"/>
    <dbReference type="FunCoup" id="A0A068U8G3">
        <property type="interactions" value="2593"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8G3"/>
    <dbReference type="Gramene" id="CDP04484">
        <property type="protein sequence ID" value="CDP04484"/>
        <property type="gene ID" value="GSCOC_T00017894001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8G3"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8G3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="247" mass="27952" checksum="4B5E85C3081905CB" modified="2014-10-01" version="1">MAEDLVLDTAIRDWVLIPLSVVMVLIGVLRYFVSKLMRSSSQLPDPKIVKEGQVIIRARNLRAAANFIPAKSFRARKVYYSNEENGLLFVPKGQAQNAQAQMFSDPNMAMDMMKKNLSMIIPQTLTFAWVNFFFSGFVAAKIPFPLTQRFRSMLQNGIDLSTVDVSYVSSRSWYFLNLFGLRGLFSLILGEENATDDTQRMMQMSGFGMDPSKSLSAEKDGLDIVQHEWALPKFEQRAEAALRKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAG5</accession>
    <name>A0A068UAG5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00020548001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol polyphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAG5"/>
    <dbReference type="FunCoup" id="A0A068UAG5">
        <property type="interactions" value="1840"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAG5"/>
    <dbReference type="Gramene" id="CDP05481">
        <property type="protein sequence ID" value="CDP05481"/>
        <property type="gene ID" value="GSCOC_T00020548001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAG5"/>
    <dbReference type="OMA" id="VACCHLA"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAG5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000053">
        <property type="entry name" value="Type IV inositol polyphosphate 5-phosphatase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045849">
        <property type="entry name" value="IP5P_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666">
        <property type="entry name" value="TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45666:SF18">
        <property type="entry name" value="TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="431" mass="49076" checksum="0E0B43CAFDC7E601" modified="2014-10-01" version="1">MWPRLIASKILSKRVGSNNFVADFPSGTETWLELPSLNKRYLSSGSILPDHEETETYKIFASTWNVGGVAPTNDLNMDDWLETCNTTCDVYVFGFQEVVPLRAANVFGCENKKITMQWNSIVREALNKKECKEKKGQNSSSSGDWNSFESEKSDSQKFRCIISKQMVGILISVWIRSDLLSFVRNPSVSCVGCGIMGCLGNKGSVSVRFRLHETSFCFVCSHLASGGRGGDEKYRNSNAAEILSRTIFPRGPSLDLPRKILDHDRVVWLGDLNYRISLPESDTRLLVDKEEWNALLENDQLRTKLKDGQVFEGWQEGTIEFAPTYKYCPNSDSYYGIFGSGKGDKKRSPAWCDRIIWFGEGMKQQLYARGESKLSDHRPVKAIFSTEMKISRKLKEFQSFFWSERFEQMTHSFDIHSADDFKCNARTSLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBA9</accession>
    <name>A0A068UBA9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00019803001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBA9"/>
    <dbReference type="STRING" id="49390.A0A068UBA9"/>
    <dbReference type="Gramene" id="CDP04933">
        <property type="protein sequence ID" value="CDP04933"/>
        <property type="gene ID" value="GSCOC_T00019803001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBA9"/>
    <dbReference type="OMA" id="MRWLKGE"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBA9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000595">
        <property type="entry name" value="ATPase family AAA domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="294" mass="32409" checksum="C571CAD7EC96F0EB" modified="2014-10-01" version="1">MSTISHGTGKQSTSQRGNGFGDVVLNPSLQKRIQQLASATANTKSHQAPFRNMLFYGPPGTGKTMAARELAQRSGLDYALMTGGDVAPLGSQAVTKIHQLFDWSKKSKKGLLLFIDEADAFLCERNKIYMSEAQRSALNALLFRTGDQSKDIVLALATNRPGDLDTAVADRIDEVLEFPLPGEDERFKLLKLYLDKYIAQAGERKSGLFSNFFRKQQQKIEIKGLTDDILREAAAKTEGFSGREIAKLMASVQAAVYGSENCVLDPNLFREVVDYKVAEHQQRRKLATDEGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBK5</accession>
    <name>A0A068UBK5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00019926001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UBK5">
        <property type="interactions" value="2779"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBK5"/>
    <dbReference type="Gramene" id="CDP05023">
        <property type="protein sequence ID" value="CDP05023"/>
        <property type="gene ID" value="GSCOC_T00019926001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBK5"/>
    <dbReference type="OMA" id="WGKLISF"/>
    <dbReference type="OrthoDB" id="19988at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBK5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="589"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP05023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2372" mass="267871" checksum="9C7BF22E10E04F57" modified="2014-10-01" version="1">MGGGVREVLFEVRRHASGTYPNYPPTGQQLDDGRGRTLLSYFSLRGITQMTERWAEYRNPKKLGKHAALFISPHADRVAVAFRNQITFLQKDDDYQQPSGTFTSGNISAFTCGTWSEAHEVLGVFDDTNTLYFIKANGEEIARITGKHLKVSLPILCLILQDGNDVNKACLCTFSILTSDGSLHDLEISQDLSASMSAAPLARTGVMLKKQFPKNVFCMHHHPKLSLFATISSASGVAISNTSGHPGSPSLSLWQRSSSSDLELMVSIDFEGLYAQAKGVDQLISPKVLISPEGNFVGTLDAKGCLLIFKFHQKQWSLSNLYNTKRYDLQMKNDLSGGGMDFLNDLVDFTWWSDDVLAVAKRDGTITMFDVPTGVKLLEKDPVYSMPIMETVEKLSGCLFLLESTSGQSYKSSEEKRTTDLRLIEQLECAKLQWNLFSLSERSVSEMYDLLIRKQDYQVALSFAHHHGLDKDELLKSQWMSSSQGVNEINKLLSTIKDHVFVLSECVDCVGPTEDAEKALLAYGLHLTEDYRFSKSQEDESSQVWDFRMARLKLLLFRDRLETFLGINMGRFSAQEYNKFRNLPINDAAVALAETGKIGALNLLFKRHPYSLGPYILEVLAAIPETVPVQSYAQLLPGNSPPASIALREEDWVECDKMVSFINSLPEDHGSRVLIRTEPIVKRYMGFQWPSTADLSSWYKNRARDIDTLSGQLENCMCLVDFGYQKGISELQHFYEDISFLRQLIYSDENEGKRNFFLSLIAWEKLSDYEKFRLLLVGVTEEDVIGRLKNIAIPFMQKRDYHIAADSTDELIGSQCTMDNTADSFLVRWLKEISLENKLGLCLIVFEEGCTDLENSYFFKDEAQVVDCALQCMYLCSSTDRWSTMSSILSKLQHLRGYGNEDLKTRLKVTEGHVEAGRILAIYQVPKPINYFREAHTDEKGVKQTLRLILSKFIRRQMGRSDNDWANMWRDLQSLQEKAFPFLDLEYMLIEFCRGLLKAGKFPLARNYLKSTGSVVLAADKAETLVIQAAREYFFSASSLDCPEIWKAKECLNILPSSRNARAEADIIDALTLKLPKLGVNVLPLQFRQMKDPLEIIKLAITSQDGAYLNVDELIEIAKLLGLSSHDEISSVQEAIAREAAVAGDLQLAFDLCRVLAKKGHGSVWDLCAALARGPALDNMDVNSRKHLLGFSLSHCDEESIGDLLNGWKDLDMMGQCETLMMLTGSEPPESAVQENLPFENGYQWESILRENGKILSFSALHLPWLLELITKAETTKKHISGSVSGKQYISVRTQAVVTIISWLARNGFAPKDNLIISIAKSIMEPPVTEEEDIMGCSFLLNLVDGFSGVDIIEGFVKARESYNEITSIMNVGLIYGLLHNRRGECEEPAQRRMLLLREFQQKHKSVASDERDELDKAQSAFWREWKLKLEEQKRVADHSRVLEQIIPGVETARFLSGDTSYRESVVFSFIESIKLEKKHVLEDVIKLAHTYGLDQTKVLLHYISSTFTSEAWTVDDIVADLSQFRKEVISSAAETITVITVSVYPLIDGHDKQRLAYIYGLLAECYLQLEELKEPLPTIGQSPMHLDAIHLARFSKVVSQECFRVSFIGGLNFKKIAGLTDLNWDSFNDEVFSHISEKNVEALADMVRNLIGLYGDSLPEGLLSWQFVYRHHVLNLLTTFETQFKTDGLSESPENFHCFLSELEQTYNAVLKYVKFIEYPGILDIMMRFFAVMVPFEKPSSKCFDSLWQECLLKLLNMWLRMMSDMQELKSLEHSDESFCSESLVTCLKVFINLILKGKVSPIEGWGTIISFSNSGVNGDAIVEIFNFCRAMLFSGCRFLAVAYVFTDALSQLSPGSALASSTGRYYINIQDLPHLYISLLEVILLDLDSGSLEKQKFHSFLSSLSKLEGNLEELKCVRDSVWKKLAEVSDNLQLPSHSRVYILELMQCIRATDKELKVFSSELDTYVIPWEGWENVQSGCVNHEKTSDCGMSNVADTANRFTNTLVALKSSQMLSAISPSLEIAPEDLLTTESAVSCFVKVSESAKSESEIDALIAMLGVWEELFMYGRKDSPKVDDIGNSWSNDDWDEGWESFLEESREKESKSNSTLLVHPLHVCWLEIFKKLIRLSRYEEFLRLADKYKGNTTQILLDEDDARCLSQIMLELNCFIALKIMLLLPYEAVQLQCLEAVEVKLKQTGIPDEFGKDYEFLLLLLSSGIVVPIITKSSYGTTFSCLCYMFGNVSRQWQEAQLSSLKYMIASEDKSNLNLIFVFTRLLFPCFLAELVKADQQILAGFFVTKFMHTSASFSIVNVVDASLRRYFEKQLQLLDDDEASWEGINSSEPLLNTILSFRDRLGELIPSALSLLPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBP2</accession>
    <name>A0A068UBP2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021223001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBP2"/>
    <dbReference type="FunCoup" id="A0A068UBP2">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBP2"/>
    <dbReference type="Gramene" id="CDP05906">
        <property type="protein sequence ID" value="CDP05906"/>
        <property type="gene ID" value="GSCOC_T00021223001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBP2"/>
    <dbReference type="OMA" id="HINNWIR"/>
    <dbReference type="OrthoDB" id="594804at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBP2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd22160">
        <property type="entry name" value="F-box_AtFBL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053781">
        <property type="entry name" value="F-box_AtFBL13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006566">
        <property type="entry name" value="FBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050232">
        <property type="entry name" value="FBL13/AtMIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055357">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31900:SF34">
        <property type="entry name" value="EMB|CAB62440.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31900">
        <property type="entry name" value="F-BOX/RNI SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08387">
        <property type="entry name" value="FBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23622">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00579">
        <property type="entry name" value="FBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="465" mass="53206" checksum="DE2DFB7E38F091B1" modified="2014-10-01" version="1">MVKNILRLPFWQIKSGFASPSAAENSEPKRQKLSNESTTEPAIDMISDLPELVLFHILSFLPTNDAVATSILSTKWRFLWAKMTIFNFDDGLFPADAGKRETFVNFVDRVFLVTAATFMKKLSLKCGKRCGQNHINNWIRTAIGRGVEDLDLTTYGHGLDYRLPGSSLFICKTLVALNLSGDVVINETSSGSFPNLKILYLTSVKYQSDDSVRKFISSCLVLEQLTVVRDREDNVVTFTISAPTLKHLTIDFRSCSDDSDRALKINAPALQCLNLFDDLSINFMVEDLTSLVEAKVDVFNKKMLMYNEGYRDSVIGFLMSLHNAKILCLRYHSVEVLSYYWISTRFQNLIRLVLQSRYCDWIALEDLLQQAENLETFHVNARFIHWREPEQVPKCVSSTLTRIFLGSFGCVKYERTMVKYFLNNAKVLKSMELLTYNVDELKKENTLQKILRFQRASQACQIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC64</accession>
    <name>A0A068UC64_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00020161001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC64"/>
    <dbReference type="FunCoup" id="A0A068UC64">
        <property type="interactions" value="1195"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05198">
        <property type="protein sequence ID" value="CDP05198"/>
        <property type="gene ID" value="GSCOC_T00020161001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC64"/>
    <dbReference type="OMA" id="WGNSHEK"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC64"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF99">
        <property type="entry name" value="OS04G0534100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="200"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="530" mass="61980" checksum="D48D707A1C99D9AC" modified="2014-10-01" version="1">MQAIKDRAHIKEHRLRNQHYWRSSVLPLLFLIILSIAAIVYTRLLDSSSIAQNYSEHSIFTGITFHNYHSREYTKKTTQSDEFPVKKVEIPLNCTAGISKRTCPANYYPSQLLVQDQNIATSPPQPTCPDYFRWIHEDLWPWRETGITLEMLSMARKTAHFRLVIVNGRAYMEKFRRSHHSRDTFTLWGILQLLRKYPGQLPDLELMFDCNDRPAIMKEVQSGPNSPAPPPLFAYCRDDATLDIVFPDWSFWGWPELNIKPWESLSKDLKEGNERSRWVEREPHAYWKGNPAVARNRLDMAKCNVSDKQDWNARIYSQDWIREQQQGYKQSDLASQCTHRYKIYIEGVGWSVSEKYILACDSLTLLVKPRYYDFFARSLMPLEHYWPIRNDDKCRSIKHAVDWGNTHPQEAQAIGKAASSFIQEELKMDYVYDYMFHLLSGYAKLLKFKPGVPREAVEVCSEFMACPAQGLVKEMMMETFARGPSDAPPCTMPPPYDPQTLHSILERKENSMKQAETLEKQYWDARNKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDE0</accession>
    <name>A0A068UDE0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00023397001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Inorganic phosphate and probable anion transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sodium/anion cotransporter (TC 2.A.1.14) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDE0"/>
    <dbReference type="FunCoup" id="A0A068UDE0">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDE0"/>
    <dbReference type="Gramene" id="CDP06516">
        <property type="protein sequence ID" value="CDP06516"/>
        <property type="gene ID" value="GSCOC_T00023397001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDE0"/>
    <dbReference type="OMA" id="VTTIFWN"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDE0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000131">
        <property type="entry name" value="Probable anion transporter 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000142">
        <property type="entry name" value="probable anion transporter 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654814" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="8"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="417" mass="44676" checksum="B4CB1317EEE6477F" modified="2014-10-01" version="1">MVAERFKVVALVASIMCLCNADRVVMSVAIVPLAAQHGWSSSFLGIVQSSFLWGYIFSSVIGGALVDKYGGKRVIAWGGALWSLATLLTPWAANHSTASLLAVRAFFGLAEGVALPSMNTLLSRWFPSHERATAVGISMGGFHLGNVVGLVLTPLVMSSVGISGPFILFSSLGLLWLTTWVYRVTNDPQDSSTIRKSELRLIQAGKSDSSATKGKLPPLGLILSKLPAWAIILANVTNNWGYFVLLSWMPVYFKTVFGVNLKQAAWFSAVPWGTMAISGYIAGAISDYLIKAGYSLTLVRKIMQSIGFIGPGVALLCLNFAKTPEVAAVFITVALSLSSFSQAGFLLNMQDIAPQYAGFLHGISNSAGTLAAIISTIGTGFFVQWLGSFQAFLTVTACLYFVTTIFWNLYATGEKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE62</accession>
    <name>A0A068UE62_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021244001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE62"/>
    <dbReference type="FunCoup" id="A0A068UE62">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05923">
        <property type="protein sequence ID" value="CDP05923"/>
        <property type="gene ID" value="GSCOC_T00021244001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE62"/>
    <dbReference type="OMA" id="SACWNSY"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009640">
        <property type="term" value="P:photomorphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044630">
        <property type="entry name" value="SPA1/2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44218">
        <property type="entry name" value="PROTEIN SPA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44218:SF1">
        <property type="entry name" value="PROTEIN SPA1-RELATED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP05923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="715" mass="80060" checksum="CDCC424DD6418276" modified="2014-10-01" version="1">MEGSSESGWQRSDSSRGLNSSSVLEGNLRLVRANTIRSSGDTSSEFGFRPGRKVRERIVLPHITNQFKTYTGGFEEGVALDPVVRAIECNDISLRQWLDNPERTVDALECLHIFTQIVDIVNLAHSQGIILHNVRPSCFVMSSLNRVSFIESASCSDSGSDSFEEGTNSQTAEFKGASSPLPSDLPQRGSQLATETLQLEMNPLNASRIVSETSCIRSSARQAEVAPNDDQTEERKHSFPMKHILLMETNWYNCPEEVSGGPSSSASDIYRLGVLLFELFCTFSSVEEKSATMSSLRHRVLPPQLLLKWPKEASFCLWLLHPEPSSRPKMGELLQSEFLNEPRDNIEEREAAIELREKIDEQELLLEFLLLLKQRKQDAADHLHEMVSFLTSDIEEVTKLQTALRIKGGTSIDLVKDSASGPPSSNTVDEGDSGSSGSRKRCRPGLYTHNAEELDDPVPENQATILSKSSRLMKNFRKLESAYFLTRRRALKPSGKVYARSSPISSDARGSVVATERSSLSKLSSKEQYNEDRQSGWINSFLEGLCKYLSFSKLKVKADLKQGDLLNSSNLVCSLSFDRDGEFFATAGVNKKIKVFEYNSILNKDRDIHYPVVEMASRSKLSSICWNGYIKSQIASSNFEGVVQVWDVTRSQIFMEMSEHESRVWSVDYSVADPTLLASGSDDGSVKLWNINQAILFLHLVDVSFETKRSKHRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFZ4</accession>
    <name>A0A068UFZ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable glutathione S-transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00023444001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. HSP26 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFZ4"/>
    <dbReference type="FunCoup" id="A0A068UFZ4">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFZ4"/>
    <dbReference type="Gramene" id="CDP06553">
        <property type="protein sequence ID" value="CDP06553"/>
        <property type="gene ID" value="GSCOC_T00023444001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFZ4"/>
    <dbReference type="OMA" id="MEDYNAN"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFZ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000012">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF676">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP06553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="233" mass="26568" checksum="9A89C7EB46D2FB1B" modified="2014-10-01" version="1">MEEVKLFGHPASPFSCRVEIALKLKGVHYDFIAEDPSNKSPQLLQYNPVHKKIPVLLHNGKPIAESLVILEYIDEVWKTNPILPQNPHEKAKARFWANYVEEKCLPALFKTFWSVGEQYDKDKAEAGEVLKFLEDELQGKKFFGGDSIGLVDIVANFMAFWFRTIQEALGLDVLTKDNFPKLWEWAENYVNCSDINQFLPPKDKLIAIFPPPYMGQHLVAFFQSRLAAAAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHE1</accession>
    <name>A0A068UHE1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024994001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHE1"/>
    <dbReference type="FunCoup" id="A0A068UHE1">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHE1"/>
    <dbReference type="Gramene" id="CDP07667">
        <property type="protein sequence ID" value="CDP07667"/>
        <property type="gene ID" value="GSCOC_T00024994001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHE1"/>
    <dbReference type="OMA" id="VNDESHF"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHE1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34574:SF5">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34574">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="140" mass="15523" checksum="59BB950221F0AA32" modified="2014-10-01" version="1">MGVVIIDGSTVRDFVANEAEFNKSADEKFAALDLNNDGVLSRSELRKSFESFRLLETHFGVDVATPPDELTKLYDSIFEKFDCDNSGTIDREEFRNEMKKIMLAIADGLGTCPIQMALEDDDDSFLKQAADLEASKVNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIA2</accession>
    <name>A0A068UIA2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectinesterase</fullName>
            <ecNumber evidence="5 13">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00026690001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
            <location evidence="1 13">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 13"/>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIA2"/>
    <dbReference type="FunCoup" id="A0A068UIA2">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIA2"/>
    <dbReference type="Gramene" id="CDP08022">
        <property type="protein sequence ID" value="CDP08022"/>
        <property type="gene ID" value="GSCOC_T00026690001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIA2"/>
    <dbReference type="OMA" id="FFKISMH"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIA2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6 13" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104088" description="Pectinesterase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="14">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP08022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="534" mass="58317" checksum="FDF089395EAE2D81" modified="2014-10-01" version="1">MAFPLAIFLFMTVFVSPALARNIPPPPSIKSWCAQTPYPQPCEYFLSQSPKYGYNYPIKGKSDFFKMSLNLALERAVHAQENTNNLGSKCRDEREKAAWEDCLELYESTIVKINKTVDPYTKCNAVDAQTWLSTALTNLETCKQGFIELGVADHLVPLMSNNVSCLISNTLSLNKVGYNEPSYKEGFPTWVTPGDRKLLQSSSPTPNAVVAQDGSGNFKTVAAAVAAAATRSGNGRYVIHVKAGTYKENVEIGTKLKNIMLVGDGIGKTIIMGSNSVGGGTTTFKSATVAVVGDGFIARGITFRNTAGPQNHQAVALRSGSDLSVFYQCSFEGYQDTLYVHSQRQFYSECDVYGTVDYIFGNAAVVFQNCNLYSRNPPNKINTITAQGRTDPNQNTGISIHNSRVTAASDLKPVQSSVKTYLGRPWQQYSRTVFMKTFLDGLIDPAGWLPWSGNFALDTLYYGEYANTGPGSSTANRVSWKGYHLITSATEASKFTVGNFIPVGADVVRGHTPKTLYPAFLWRPIVYLSASAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIK1</accession>
    <name>A0A068UIK1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00027177001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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    <dbReference type="OMA" id="KPNDHEG"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="9" id="KW-0862">Zinc</keyword>
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            <end position="263"/>
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    </evidence>
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    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="3">DUF4228 domain protein</fullName>
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        <lineage>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Jayarama X."/>
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                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="213" mass="23624" checksum="EF3763EB7B432C04" modified="2014-10-01" version="1">MGNAISPYCCQLTSSSIVKLIFYGGKTRVVSAGKASAGKIMFEFPDHMVCHADSFFIGHPIPVLDIDDELIAGETYFVLPLDCFTNNVLSASSLATLRRSISSGSKPAAVNFKECPFEHVKGTNGRVLIKVRPEFIIKLLTRDQETGDEDSRSLSPSHGFLCSTPELKKHYDQMVGSKDNAWSPKLETITEYKIRYSPCRFIGFERKQGEAEC</sequence>
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    <name>A0A068UKB4_COFCA</name>
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        <lineage>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKB4"/>
    <dbReference type="Gramene" id="CDP08916">
        <property type="protein sequence ID" value="CDP08916"/>
        <property type="gene ID" value="GSCOC_T00028050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKB4"/>
    <dbReference type="OMA" id="NFVQGWV"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carpel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MADS_MEF2_like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
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        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="K-box" evidence="8">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="249" mass="28229" checksum="548DE3397B0CC2B5" modified="2014-10-01" version="1">MGRGRVELKRIENKINRQVTFSKRRNGLLKKAYELSVLCDAEVALIIFSSRGKLYEFGSSGITKTLERYQRCSLSPQENAAERETQSWYQEVSKLKAKYESLQRAQRHLLGEDLGPLNVKELQNLEKQLEGALLQARQRKTQLMIEQMEELRRKERQLGDLNKQLKIKVSLEMSSLEAAEGQGLRALPCLWSSSVPSGSSMFPMHPSAMDCDPEPVLQIGYHHQYAPAEGPSAPRSMAIESNIIQGWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKI5</accession>
    <name>A0A068UKI5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027764001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
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    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gramene" id="CDP08704">
        <property type="protein sequence ID" value="CDP08704"/>
        <property type="gene ID" value="GSCOC_T00027764001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKI5"/>
    <dbReference type="OMA" id="AYTWLLH"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKI5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000051">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000054">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48046:SF6">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48046">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 72E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="470" mass="51514" checksum="2FF0077C396EDD2B" modified="2014-10-01" version="1">MDQTPRVALLPSPGMGHLIPLVEFAKRLILQHDFSVTIILPTDGPLSKAQTTFLAALPAAIDYILLPPVNFDDLADDVRIETRISLTVTRSLPSLRDALKSLVDTAKLAALVVDLFGTDAFDVANEFKLPPYIFFPSTATALAFFSYLPKLHEMVACEFRDLPGPIRVPGCVPIHGRDLLDPAQDRKNDAYKWLLHHARRYSLAEGIVVNSFKDLEPGPLKALQEQEPGKPPVYPVGPLIQMGSGEKRGEEPECLKWLDDQPSGSVLYISFGSGGTLSHNQLVELAFGLEMSEQRFLWVVRSPNDGVANATYFTVNSQNDPLAFMPEGFLDRIKGRGFLVPSWAPQAKILGHSSTGGFLTHCGWNSTLESVVEGIPLIAWPLYAEQKMNAVMLAEDLKVASRPKADENGFVGRVEIANMVKRLMEGEEGKGLRSRMKELKDAAAKVLSQDGSSTEALAQVAGKWQAKICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKI9</accession>
    <name>A0A068UKI9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator complex subunit Med12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00027917001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UKI9">
        <property type="interactions" value="1763"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKI9"/>
    <dbReference type="Gramene" id="CDP08812">
        <property type="protein sequence ID" value="CDP08812"/>
        <property type="gene ID" value="GSCOC_T00027917001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKI9"/>
    <dbReference type="OMA" id="DCEDCAR"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKI9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090213">
        <property type="term" value="P:regulation of radial pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="7">
        <location>
            <begin position="157"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1942"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1942"/>
            <end position="1952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2266" mass="250477" checksum="2CFCCE8527CD0ED4" modified="2014-10-01" version="1">MQRYHAASCTSAVNNTAIGGSARDVSRAESSSIPSNFSLNSRRPLPLTPYKLRCDKEPLNSRLGPPDFHLQTPTCPEETLTRDYVQSGYRETVEGIEENRETSLSQIQAFTKPVILKCKESIRKCHRAINESRAQKRKAGQVYGVPLSGSLLSKPGAFPEQKPCGEEFRKKWIEGLSQPHKRLCSLADHVPHGYRRKSLLEVLIRNNVPLLRATWFVKVTYLNQVRPGSSNLSGGVPDKTQFSRSEQWTKDIIDYLQAFLDEFVSKNNFHSTLHIRDRSPQMVYPGTLQHRNDAASTSTDADEPSLHFKWWYVVRLLQWHHAEGLIVPSLIIDWVFNQLQEKERLGILQLLLPVIYGVIEAVVLCQTYVRTLVGIAMRFIQEPSPGGSDLVDNSRRAYTMSALVEMLHYLIIAVPDTFVALDCFPLPLCLVTNVVNDGSFLLKIAEDESNMKTGPLEVACLQRDKGVEVHPDSLTINCIVSSIQKRAENLAKAARPGHPSQNVAKALLALDKSLIHGDVSVAYKLLFENLCDGAVDERWIAEVSLCLRSSLKYIGVVTLSFISSIFFICEWATCDFRDFRTGPPSGQKFTGRKDLSQIYIAIRILQLKRREMQSLSQGKNESSLAPDTLAKDPDLQNNYPGRFPVGNACEQNKYSLKSGKTRNLSNIFESPSPLHDIIVCWIDQHEVHSGEGVKRLQLLIMELVRAGIFYPQAYVRQLIVSGIMDGNGISVDLERRKRHHRILKQLPSSYVHDALEEAQVLEGAMLLEVINTYANERRLVLRGLLDCHKSSGSSWQKQKHYYNSGGGSDPSSVDQWRSLQGISSLTTKNVDQVVELEDLKASIVMLLQLPSSSLSSDSGLENFVGGFKRSTGSSITKIDIGEGTPGCEECRRVKRQKLSEDRSSYPQGFLSNALDDEDIWWLRRGPKSLDKMDPPPKQAKQSGRGRQKGVRKTQSLAQLAAARIEGSQGASTSHVCDNRVNCPHHRTGVEGDAPKSGDGIRMAYGSDIVSIGKVLKKMRLVEKRTVMLWLISVVKHLVEEAEKTAAKVGQYGRPYSAVDDANSVRWKLGEDELSMFLYLMDVSNELVSAARFLLWLLPKALSSPAASIHAGRNILMLPRNTENVVCEVGEAFLVSSIRRYENIIVAADLVPETLKAAMHRVAATMASTGRVSGSSALVYARNLVKKYGNVASVVDWEKNLKSSYDKRLISELESGRLPDAEFGFPLGVPAGVEDLDDFFRHKISGVRVSRVALTMRDIVQRQVDEVFQYFFGKERKLFGPGTVKSPVLENLDDGYQIAQQIVMGLMECMRQTGGAAQEGDPTLVSSAISAIVSNVGLVIAKIPDLTAGNHLNFQSTSSSMHFARRILRIHTTCLCLLKDALGERQSRVFEVALAVEASTALAQVFVPGKAPRTQFHPSPESHDSSSNSYEALNSSVKSVLGRGAKIAGAISALLVGALLQGVTSLERMVTLFRLREGLDPIHFFRSLKSNSNGSARSIGALKLDNLVEVSTHWFRVLVGNCRTVSDGFIVELLGEASVVGLSRMQRTLPLNLVFPPAYSIFAFVIWKGLIFNTGVGLRDDLQQLYQSLALAIGDALKHLPFRDVCLRDTHGLYDLIAADAIDSEFAALLESHSADVLYKSMAFVPLRARLFLNALIDCRMPQSLLKPEDVNRMQGQGGLKNYYQEKDANFRDKLVHVLDTLQPAKFHWQWVELRLLLNEQTVIDKLKNEAPLAEAIKSVSPNADKVAVSEKESSFVELVVMRLLARPDAASLFSEVVHLFGRSLEDQMLMQTKWLLGGTDVLYGRKSIRQRLIINAEKEHLSTKLQFWKPWGWCDSNSDSRKTRGSKRKFEVASLEEGEVVDEGSDVRFPGRGSTQVVDVEGFLVSQQHVTERAFIELVLPCVDQGSDASRNTFANDMIKQMNNIEQQINVLSHGAAKSVGSVASGAESPASKGNSRKGMRGGSPGLSNSRRPAGPADGVPSSPAGLRASMSLRLQFLLRLLPTMCTDGEPGKSMRQMLAAVILRLLGCRVVHEAAGHTTSSTLNLSKRDVESLTEASATSVLLSGESLFDCLLLLLHGLLSSYRPSWLKLKSNSKSASECGKDFSVFGREVAENLQNDLNRMHMPDHIRWRIQTAMPILLPSVRCSISCQPPSISPASIAALQSSNQISVLQPHNSILSQRNPVSLVRTVANMAGKAKQLPLQDLDLEIDPWTLLEDGTGVQSSSNSAAIGGSDHANLRASNWLKGAIRVRRTDLAYIGAIDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKY2</accession>
    <name>A0A068UKY2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00028125001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKY2"/>
    <dbReference type="FunCoup" id="A0A068UKY2">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKY2"/>
    <dbReference type="Gramene" id="CDP08972">
        <property type="protein sequence ID" value="CDP08972"/>
        <property type="gene ID" value="GSCOC_T00028125001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKY2"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKY2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000044">
        <property type="entry name" value="Polymerase/histidinol phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="669" mass="74274" checksum="B0FD4E371A1A9103" modified="2014-10-01" version="1">MGFFDLNIPYHESDRHVTETTTYKSNRLKLVIKAAELGYTGVAYNRVIKGVMSESDRCSTSLFPLSSLLKHAPSFSSSVKFHRDLLNVPVSTPFRQYSRLTVVIDCPAQAAALNSGNPVIKSYDIVAVRPINQNAFEQACQTSEVDIIAIDFSEKLPFRLKQSMVKAAVKRGVYFEISYSSLIVDAQVRRQTISNCKLLVDWTRGKNLVISSAAASVSELRGPYDVANLFSLIGLPFEHAKAAVSKNCRSVIVNALRKKHYYKDAIKVEVMPSSGKVNPKESVFSDWLKWDPISSGEGDLLLDDIEKSFSASGSVHNTVKTVGFASALNSLPSHGLQIKEILSAVESASEALDIGKNLSGADESKLTVSVSGISEELSRTNLLPEEIQTSENDRHQSPRHQDSEMRTLPNGSVNDSTLAEKEINHVVATMELKTAKDLDADLPASDREFHNLHSQSCLDSYEQVPLADHMTNRYSADDADTAHTCHDIANAEILFHSKDVLSTFHGEEAKMPISSTKGLYAESGSVVDKIEMDRENKKIPAFAVSDTHSNEEFRENKQFQEKLENLAAFAIEIPNEESHDPAKKANGSLVSEVEPIEEDMASELMEEDEMEGRRKLKGEVAMHYQFLSKSVSGRGRGKRRSVHQKIPFNLKHILNSRPFKRKARKLNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULA8</accession>
    <name>A0A068ULA8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028202001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULA8"/>
    <dbReference type="Gramene" id="CDP09029">
        <property type="protein sequence ID" value="CDP09029"/>
        <property type="gene ID" value="GSCOC_T00028202001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULA8"/>
    <dbReference type="OrthoDB" id="10066542at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULA8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5616" checksum="B278B7D957CF5340" modified="2014-10-01" version="1">MAPLLLSPSFAYTVVYVRDVAKSVEFYATAFGHNVRRLDESHRWGELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM15</accession>
    <name>A0A068UM15_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00028524001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM15"/>
    <dbReference type="STRING" id="49390.A0A068UM15"/>
    <dbReference type="Gramene" id="CDP09264">
        <property type="protein sequence ID" value="CDP09264"/>
        <property type="gene ID" value="GSCOC_T00028524001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM15"/>
    <dbReference type="OMA" id="HGHITHR"/>
    <dbReference type="OrthoDB" id="1931471at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM15"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF62">
        <property type="entry name" value="OS05G0423500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="146" mass="16677" checksum="5592F2F68C7D32D8" modified="2014-10-01" version="1">MRKTYIYLSLLSFFQGYEFRPNSSLYTSTKEDSNTLDKSNSNRPQIFAQINGIHYLHTGSAQGIIHRDIKSTNILLDESYVAKVANFGLSRSGPCLNETHLTNKSDVYSFGVVLFEVLCARPAVDPLFGHDEERMKKKWPKGKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNK9</accession>
    <name>A0A068UNK9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00028393001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNK9"/>
    <dbReference type="FunCoup" id="A0A068UNK9">
        <property type="interactions" value="1642"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNK9"/>
    <dbReference type="Gramene" id="CDP09173">
        <property type="protein sequence ID" value="CDP09173"/>
        <property type="gene ID" value="GSCOC_T00028393001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNK9"/>
    <dbReference type="OMA" id="WPTDEVY"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNK9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000686">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc6 C-terminal" evidence="10">
        <location>
            <begin position="416"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP09173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="507" mass="56256" checksum="30D34BB42790B689" modified="2014-10-01" version="1">MPNLAGRRLSPVDVIKAALGDSSPHKRKLRSDSSTRDGSDSSVPLPMQSSPVKWKSPRRCPNDSPKINSPSKDNEKFSRGKAMTSSKLPVKKKLSDNVDQLSSVKEALHVSTSPSTVVCRENERTRMLEFCQRCIELETSGSMYVCGCPGTGKSLMMEKVKEALVEWAKEAGLQPPDIVAINCTSLANTSEIFSKILGKSSLQNKSGGSISPLKTLQNNYSQKQHSNGMKMTLIIADELDYLITKDRAVLHDLFLLTTLPFSRCILIGIANAIDLAHKFLPKLQSLNCKPMVITFRPYSKDEIIVILRQRLVALPYVVFQPQALELCARRVAAASGDLRKALWVSRSAIEILEAEIRDSIDYLNLSGVDERFGTTLAKQDSTIVRVDHMALALSKAYRSPVVDTIQSLPQHQQIILCSAVKLYRRGKKHTTIGELNRSYNDVCKSTLIPPAGIVELSSMCRVLVDQGLLKLGQSREDKLRRVTLNVDEADINFALQGVRFFRNCLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR89</accession>
    <name>A0A068UR89_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase-like plant mobile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031940001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR89"/>
    <dbReference type="STRING" id="49390.A0A068UR89"/>
    <dbReference type="Gramene" id="CDP10956">
        <property type="protein sequence ID" value="CDP10956"/>
        <property type="gene ID" value="GSCOC_T00031940001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR89"/>
    <dbReference type="OMA" id="TAYETIV"/>
    <dbReference type="OrthoDB" id="1751334at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010073">
        <property type="term" value="P:meristem maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019557">
        <property type="entry name" value="AminoTfrase-like_pln_mobile"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044824">
        <property type="entry name" value="MAIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46033">
        <property type="entry name" value="PROTEIN MAIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46033:SF8">
        <property type="entry name" value="PROTEIN MAINTENANCE OF MERISTEMS-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10536">
        <property type="entry name" value="PMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase-like plant mobile" evidence="1">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="213" mass="24917" checksum="CAF3A6457BD7ED1B" modified="2014-10-01" version="1">MLLQLWAWERMPRIRPTVLFPAAQADNFPRGGRWAGERTTRYVPSHVVSLFRDALTKMGADEFIWEPYSTDLIAQLPAYCSAGQHIWRSVVPLIYWEVVEFNFPQRVLRQFGLFQPIPASVDTDTDKKLHSLGRSGRSGKDWVQYHSHWVQYWERRAQSVVSGYRSDPLIPLDEYIVWYQNITVRYIAPPVSRQAVDDTHRPDGGQFDYLVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URB7</accession>
    <name>A0A068URB7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00031978001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URB7"/>
    <dbReference type="FunCoup" id="A0A068URB7">
        <property type="interactions" value="1395"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URB7"/>
    <dbReference type="Gramene" id="CDP10981">
        <property type="protein sequence ID" value="CDP10981"/>
        <property type="gene ID" value="GSCOC_T00031978001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URB7"/>
    <dbReference type="OMA" id="QRIDLDC"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URB7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF75">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="7">
        <location>
            <begin position="90"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="272" mass="30719" checksum="DF63783BB2002B2C" modified="2014-10-01" version="1">MFETPKLNLHYCNHASFATKGSKPGPVSETKKFIEKVLFVPPGVDPEEVTDDLILPGSNIVLGPYAGDAKIKEVEFVKSSNRPKDCPKDDRPEFAMLGRSNVGKSSLINALVRKKEVALTSKKPGKTQLINHFLVNRSWYIVDLPGYGFANAPEAARMDWSAFTKGYFLNRETLVSVLLLVDASVPPQKIDLDCANWLGRNNIPMTLVFTKCDKMKGGKAKRPDENIRNFQQLIRENYKRHPPWIMTSSMTGLGRDELLLHLSQLRNYWNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US47</accession>
    <name>A0A068US47_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00033095001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068US47"/>
    <dbReference type="STRING" id="49390.A0A068US47"/>
    <dbReference type="Gramene" id="CDP11079">
        <property type="protein sequence ID" value="CDP11079"/>
        <property type="gene ID" value="GSCOC_T00033095001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US47"/>
    <dbReference type="OMA" id="HEWVEEM"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068US47"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000012">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF59">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655040" description="mannan endo-1,4-beta-mannosidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="41"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="391" mass="44072" checksum="E93FAA8A73D7ABFE" modified="2014-10-01" version="1">MASCSRRISHLFGLAAALVALLSLVLACEASGSTVPRNGAGFVRTQGPRFVLNGSPFLFNGFNSYWLMHVAADPKERYKVSEVLRDASAAGLSVCRTWAFGDGGDRALQISPGIYDERVFQALDFVISEANKHGIRLILSFVNNYNDFGGKGQYAQWARNAGAHVNSDDDFYTHSTIKEKTAIKSRLLCFQVLVTRLNTITRISYRDDPTIMAWELMNEPRCQADYSGRTVNEWTQEMASFVKSFDRKHLLEIGMEGFYGDTMPEKKQFNPGYQVGTDFISSNLLRDVDFATIHAYPDQWLSGKDDKAQLVFMQRWMSSHWEDSRTILKKPLVIAEFGKSSRDPGYSLSARDDYMSNVYRITYGFARSGGTMSGSLIWQEWIRTTTDTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US53</accession>
    <name>A0A068US53_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00033102001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068US53"/>
    <dbReference type="STRING" id="49390.A0A068US53"/>
    <dbReference type="Gramene" id="CDP11084">
        <property type="protein sequence ID" value="CDP11084"/>
        <property type="gene ID" value="GSCOC_T00033102001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US53"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068US53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF158">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5534" checksum="0ACF8D3929F3D68E" modified="2014-10-01" version="1">MNLSHNRMSGSIPKSFDHCFSLISIDISYNQLEGPLPNTSAFQKLHLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTZ6</accession>
    <name>A0A068UTZ6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00035389001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTZ6"/>
    <dbReference type="FunCoup" id="A0A068UTZ6">
        <property type="interactions" value="3056"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTZ6"/>
    <dbReference type="Gramene" id="CDP12030">
        <property type="protein sequence ID" value="CDP12030"/>
        <property type="gene ID" value="GSCOC_T00035389001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTZ6"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTZ6"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="15">
        <location>
            <begin position="207"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP12030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="534" mass="59765" checksum="EEAE89ABAA4355C9" modified="2014-10-01" version="1">MDSQDVKSDLVLILDYGSQYTHLITRRIRQLSVYSLCLNGTASLESIRKENPKVIILSGGPHSVHAPQAPCFPSGFIEYVESEKIPVLGICYGLQLLVQRLGGQVSIGEKQEYGRMEIEVQKACGLFGNRKVGDKQVVWMSHGDEAVKLPQGFEVAARSQQGAVAAVEDNKRRFYGFQYHPEVTHTHEGMETLQHFLFDVCGVSAEWKMKDVLEQEIKAIQEKVRLEDHVICALSGGVDSTVAATLVHKAIGDRLHCVFVDNGLLRYKERERVMETFERDLHLPVTCVDAAEQFLSQLKGVVDPEMKRKIIGKEFINIFDAFAHDLEQKFGKKPAYLVQGTLYPDVIESCPPPGTQSTHSHTIKSHHNVGGLPKNMKLKLIEPLKLLFKDEVRALGSILNVPEAFLKRHPFPGPGLAVRVLGDISQGNALDILRQVDEIFVQSIKDAGIYDKIWQAFAVFLPIRSVGVQGDQRTHSHVVALRAVTSQDGMTADWYNFEHNFLDDVARKICNSVRGVNRVVQDITSKPPSTIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX52</accession>
    <name>A0A068UX52_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate lyase 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037501001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX52"/>
    <dbReference type="STRING" id="49390.A0A068UX52"/>
    <dbReference type="Gramene" id="CDP12834">
        <property type="protein sequence ID" value="CDP12834"/>
        <property type="gene ID" value="GSCOC_T00037501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX52"/>
    <dbReference type="OMA" id="PRTEIKM"/>
    <dbReference type="OrthoDB" id="4221926at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX52"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681:SF4">
        <property type="entry name" value="OS12G0171100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658323" description="Alginate lyase 2 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="210" mass="24154" checksum="1CF29667D5FE6AC5" modified="2014-10-01" version="1">MTPFLFLATLFLTLLRALKADPTDGFSYVKLSEANFQVQKPYDVSVNQRYSYIGGEHRLWVYKTDKPYSQTSNTKPRTEIRITGYDYTSGVWQFEGYAYVPSGTSGVSIMQVFGASTQATTAMLRVYNPSLTYYTNPVLIPNVYNKWYRVNVIHDTGAARVRVYIDGVFKYETHDNGPATHYFKFGVYTQDNPSDYMESRWVGIKVLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY35</accession>
    <name>A0A068UY35_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00038416001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">cv. DH200-94</strain>
        </source>
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            <name>heme</name>
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        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
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        <property type="gene ID" value="GSCOC_T00038416001"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
        <ligand>
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        <ligandPart>
            <name>Fe</name>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="511" mass="57958" checksum="264B9A62355DD4E4" modified="2014-10-01" version="1">MEAFNFMAILASFSALLASFCALKLVFSLWWKPKIKEKQLKQQGIGGTSYNFLFGDKPVSKKLMIEAWAIPMSLNHEIVPRVDPSLHQIVQTYGKVCLSWTGTRPRLIMGKAELIRLILNDKDGHFQKPPQNPLVDLLTLGVSTLEGEKWAKRRRLITPAFHHEKLQGMVPEFLASCCNLIDRWTMLLASDGRSEIDISPELQSLSADVISRAAFGSSYIEGKKIFELQKEQAVLALEAFQALYLPGLRFLPTMKNKRRYEVDAEIKAMLRDIICKKQKAMQNGESGNGDLLGLLLQCKEEKGNEMTIEDVIEECKLFYFAGQETTANWLTWTLIVLSMHPDWQEKARQEVLRICGKTAPDVEILNRLKIVTMVLFEVLRLYPPVTGLFRYTIQRTKVGDISIPAGVEVYLPIMLLHHDSEYWGDDAEEFKPERFAEGVSKASKDQLAFYPFGWGPRICLGQSFAIIEAKLALAMILQNFSFKLSPSYTHAPHPILTLQPQHGAPIIFQQI</sequence>
</entry>
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    <name>A0A068UYQ5_COFCA</name>
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        <recommendedName>
            <fullName evidence="10">PGG domain-containing protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
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        <location>
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            <end position="254"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="290"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="10">
        <location>
            <begin position="229"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="418" mass="46271" checksum="42EB2A082437601F" modified="2014-10-01" version="1">MEKRLYDVAADGDVSTFVHLLQEDPLLLDKVSLNCQDKNPLHIAAMLGHVAFVQAILGVNSDMCLVPDRFGRNPLHIAAIKGRLAVLQELIHARPLAAREKTEGGGNILHLCVKYNQLGALQILVQTIRDHEFLNAKNDDGMTILHLAVCDKQNETIKYLLRNKVVDVNTKTANGNTALDLVQGDIYSELARSLEDAGAKRAKDISPSATAGNDGHENKSHSQPSQGGDWLARKRDALMVVASLIATMAFQAGVNPAGGVWQDDKTDYPNPHNAGEAVMAHSHPKYYKNFIRVNTVAFVSSLSTIMFLISGLPFRRKFYMWCLMVIMWLTISAIALTYGISIVIVTPKDYRKQLSHVIETAVTVWCGVMALLLLGNTIRLINRWFKGRGNNVDRRIKRGIDSSVQSQSNDKNDGLYMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ06</accession>
    <name>A0A068UZ06_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VDE lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037558001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ06"/>
    <dbReference type="FunCoup" id="A0A068UZ06">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZ06"/>
    <dbReference type="Gramene" id="CDP12878">
        <property type="protein sequence ID" value="CDP12878"/>
        <property type="gene ID" value="GSCOC_T00037558001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ06"/>
    <dbReference type="OMA" id="FTVDNCS"/>
    <dbReference type="OrthoDB" id="420426at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ06"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046422">
        <property type="term" value="F:violaxanthin de-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010028">
        <property type="term" value="P:xanthophyll cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044682">
        <property type="entry name" value="VDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010788">
        <property type="entry name" value="VDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970:SF2">
        <property type="entry name" value="OS01G0716400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07137">
        <property type="entry name" value="VDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VDE lipocalin" evidence="2">
        <location>
            <begin position="266"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="543" mass="61445" checksum="91E90B78C17C324F" modified="2014-10-01" version="1">MILNLHLAPFATVILNRRTTFTGFKTRFIQLRQSPLQFSRERASIISFSPAPLKTSTTDNFKATSTEEEEEEAVKTTEPSATPVRIVALVGENSVSPLKSSPWLDVMLHTAKRLKWVDEAYDMLVFSDGLLKSTDKTKENLHLGLRNADILLIVAVTNQESIEWVQANSVNVPSILCFESSPTLRNKLGGSIVETKSNGYIFSKLTAISQSKRKTESTKIVQSVSEAWDRHNSDDIRFSLLVVINACIRPVPILKNLRAKGFSTLNCMVKNCGPQILNCLLDPNCRKALQCLNKCSPVDQVCNYRCIASYESPCLEEFSLCVLQKNNCLELDAKIPEKPSVPPMIKFRGDNLSHETAEDLFVGWLGKLDWSWRVIAGQNPAYDQFPCQYQLFYRGKAKGSFWYEPIFRVRTLEGNLVWRRRKYRVRRGKVPATFHFSVLDNGVVSNEFWTIVDISDDFSWGLFHYHGAARVAGQSYTGAVLVSPDGMYPDETQRQRLFSALDRCDIKEWELFNVDNLSCPNPPLGLPEGSRLHSKIEPEDMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ63</accession>
    <name>A0A068UZ63_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00038897001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739161">
        <property type="protein sequence ID" value="CDP13825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ63"/>
    <dbReference type="Gramene" id="CDP13825">
        <property type="protein sequence ID" value="CDP13825"/>
        <property type="gene ID" value="GSCOC_T00038897001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ63"/>
    <dbReference type="OMA" id="TEPMESW"/>
    <dbReference type="OrthoDB" id="543442at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="91"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP13825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="37409" checksum="6D94349909EFFC8E" modified="2014-10-01" version="1">MYIGFSSSTRSVLTSHCLLGWTPTIGPKKTSKVLTIGLPIILIISLPIAISGIIYQVRIKKKFAEVLEDWEHDYGYHRFKYKDLYITTKMFRDRELLGRGDFGKVYIGVLPSSKLEVAVKRVSHDSMHGIKEFVVEIVSIGGLRHRNLVPLLGELLLVYECMPNGSLDRFRVIRGVASGLFYLHEGWEQIVIHRDVKASNVLLDSELNGRLGDFRLARLYDHGIDPQTTHVVGTLGYLAPEPTRTGKATTRTDVYTFGAFLLEIVCSRRPIEPHSPIEDDILVDRPTTRPSMRQVVLYLDRALALLDLHSLGISATRLSFASQEGFNDFNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZF7</accession>
    <name>A0A068UZF7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor</fullName>
            <shortName evidence="5">bHLH transcription factor</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Basic helix-loop-helix protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00037771001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZF7"/>
    <dbReference type="FunCoup" id="A0A068UZF7">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZF7"/>
    <dbReference type="Gramene" id="CDP13028">
        <property type="protein sequence ID" value="CDP13028"/>
        <property type="gene ID" value="GSCOC_T00037771001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZF7"/>
    <dbReference type="OMA" id="WVAGTEK"/>
    <dbReference type="OrthoDB" id="1926382at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11449">
        <property type="entry name" value="bHLH_AtAIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000078">
        <property type="entry name" value="Transcription factor bHLH13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045084">
        <property type="entry name" value="AIB/MYC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11514">
        <property type="entry name" value="MYC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11514:SF43">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="509"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="693" mass="75404" checksum="A3CB1988D10E41CD" modified="2014-10-01" version="1">MTDYRVHTKMNLWGNQTPTTLTSDDNTSMMEVFMNSADPGSLWPPMSIHQSIPSTTSSTITAAGGGGMDSSSKSLPSSSFFNQETLQQRLQTLIDGAQEYWTYAIFWQSSVVDYGGPSVLGWGDGYYRGEEDKGKRKNPLSSSSTNSLLEQEHRKKVLRELNSLIAGPQGSSDDAVDEEVTDTEWFFLISMTQSFVNGSGLPGQALYNSSPVWVAGADRLASTHCERAQQAQGFGLQTVVCIPSANGVVELGSTELIFQSSDLMNKVRVLFNFNNMDMGSGSGSGSWPVQPESDPSALWLTDPSSSAAGVKESVNNNNNTTGQGSSIPSSANNKQMLFGNDNNPSSSTLTDNPRNILNAHHNSSQQSGGFYTRELNFSEYGFEGNSVRNATCKPETGEILNFGGESTAKRSCSANGNLFSGQSPFGVGDESKSKKRSPVSRGSNDEGMLSFTSGVILPSSGVVKSSGGGGDSDHSDLEASVAKEADSSRVVDPEKKPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLHNMESDKEELRNQIDSLKKELTSKEARNFAPPPPDKDLKLASHQGSKSLDMDIDVKIIGWEAMIRVQSSKNNHPAARIMGALKDLDLELLHASVSVVNDLMIQQNTVRMGKRFYTQEQLKIALTSRVAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V057</accession>
    <name>A0A068V057_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00038107001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V057"/>
    <dbReference type="STRING" id="49390.A0A068V057"/>
    <dbReference type="Gramene" id="CDP13233">
        <property type="protein sequence ID" value="CDP13233"/>
        <property type="gene ID" value="GSCOC_T00038107001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V057"/>
    <dbReference type="OMA" id="CRKEWEI"/>
    <dbReference type="OrthoDB" id="9985979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V057"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF38">
        <property type="entry name" value="LYSINE KETOGLUTARATE REDUCTASE TRANS-SPLICING RELATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="387" mass="44318" checksum="DFDADACF4597286D" modified="2014-10-01" version="1">MKIFVAVFIGSLFGFLVGFSFPSLSLTKLNITSSLICDFSKVGHKFSSNSSRNIRDALPSLIGSRNNSLQSPNMTDLLKIWVPSNPRGAERLPPRIIANESDFFPRRLWGKPSEDLTHKPKYLVTFTVGLNQKNNINAAVKKFSENFTILLFHYDGKTSEWDEFEWSKRAIHVSVHKQTKWWYAKRFLHPSIVAPYDYIFIWDEDLGVEHFDAEQYIKLVKKHGLEISQPGLGPSNKGLTWQMTKRRGDEEVHKETTEKPGWCSDPHRPPCAAFVEIMAPVFSRGAWRCVWHMIQNDLVHGWGLDFALQRCVEPAHEKIGVVDAQWIVHQSIPSLGSQGQSENGKAPWQGVRERCRKEWAMFQNRMSNAEKAYYLGKGIDPSNFTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V096</accession>
    <name>A0A068V096_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL9c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">50S ribosomal protein L9, chloroplastic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">CL9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00039283001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739163">
        <property type="protein sequence ID" value="CDP14086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V096"/>
    <dbReference type="FunCoup" id="A0A068V096">
        <property type="interactions" value="2131"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V096"/>
    <dbReference type="Gramene" id="CDP14086">
        <property type="protein sequence ID" value="CDP14086"/>
        <property type="gene ID" value="GSCOC_T00039283001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V096"/>
    <dbReference type="OMA" id="KFAILIR"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V096"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="entry name" value="Ribosomal protein L9, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_bL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_bL9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="Ribosomal protein L9 C-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="9">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL9 C-terminal" evidence="10">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="201" mass="23244" checksum="EC33217278C90B0C" modified="2014-10-01" version="1">MAYLQYGRHILRRGSDQILPNPLFFAAQGVRYRKLEVILTTSMDKLGKAGETVKVKPGFFRNHLMPKLLAVPNIDKFAYLISEQRKIYQPKEVEEVKMVVPKTEEDRMKEYHTAARRLDSAKLVLRKLTTKDNEVREPVTKDEIVAEVARQLSVHIEPENLHLPTPLAAFGEFEVPLRLPRSIPLPDGKLQWALKLKIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V108</accession>
    <name>A0A068V108_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00040678001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V108"/>
    <dbReference type="FunCoup" id="A0A068V108">
        <property type="interactions" value="2328"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V108"/>
    <dbReference type="Gramene" id="CDP14346">
        <property type="protein sequence ID" value="CDP14346"/>
        <property type="gene ID" value="GSCOC_T00040678001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V108"/>
    <dbReference type="OMA" id="HCIMQFA"/>
    <dbReference type="OrthoDB" id="1890226at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V108"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35118">
        <property type="entry name" value="KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35118:SF3">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67904" checksum="7EDCF6AE4BFC0B1D" modified="2014-10-01" version="1">MPNAIYASTSAAAEASAYLALEDFLHASVKCLWEAFWSQDEPLPFYVSSLYNANLRFYQAEKAIAKGRFRDLCATAIMLKNPRHPLGKWDDVLELALLRPDIETLATLDVDSRPSSLAIGEALFFAVRVLLARSFSRSNIPLSLNSVFVLLLDSQYGGVVKVEADVNKLEADVNNVYGCAAEWIKNHSRISISPVDRIWNKLGNANWGDIGALQLLFATFHSIVQYAGMPKNSVEDLAADHSSRLQARRIERQLGDSSVNGNGLFRYQQRNASPEIVEVQDESIRLGSERSMKLEVGSVLWLEESDSRQGYEINEVLSDGEILYYIASSIKDSGTALFLYIGSPPTQLEPAWEDMKLWFQVQRQTKILGVMKQKGLSSKYLPQLSVSGRVIHPGQCRRPSSGGNCDHPWCGTPILVTSPVGRTVADMVRVGEFRAEEAIRCCHDCLSALHTAASAGMRHGDIRPENVICVTSGRGQPYFVLIGWGHAILEERDRPAMNLHFSSTYALQEGKLCSASDAESLVYMLYFASGAELPDLDSVEGALQWRETSWSKRLIQQKLGDMSAVLKAFADYVDSLCGTPYPMDYDIWLRRLRRHIHEEDHGKEIDRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1A8</accession>
    <name>A0A068V1A8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00040918001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739169">
        <property type="protein sequence ID" value="CDP14446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1A8"/>
    <dbReference type="FunCoup" id="A0A068V1A8">
        <property type="interactions" value="2177"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1A8"/>
    <dbReference type="Gramene" id="CDP14446">
        <property type="protein sequence ID" value="CDP14446"/>
        <property type="gene ID" value="GSCOC_T00040918001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1A8"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1A8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000658">
        <property type="entry name" value="PRK00029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP14446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="587" mass="65724" checksum="00DAD9B39499192A" modified="2014-10-01" version="1">MDSPSIAAVDSIADDLRNQSLNSNNHGGNHDGINNASKNKGVKLKLEELNWDHSFVRELPGDPRTDIMPRDVLHACYTKVSPSAEVENPQLVAWSESVAESLDLDSKEFERPDFAQIFSGASPLVGGVSYAQCYGGHQFGMWAGQLGDGRAITLGELLNSKSERWELQLKGAGKTPYSRFADGLAVLRSSIREFLCSEAMYFLGIPTTRALCLVTTGKFVTRDMFYDGNPKEEPGAIVCRVAQSFLRFGSYQIHASRGKEDLDIVRTLADYTIKHHFPHLENMSKSESVSFKTGEEDNEVVDLTSNKYAAWAVEVSERTASLIAKWQGVGFTHGVLNTDNMSVLGHTIDYGPFGFLDAFDPSYTPNTTDLPGRRYCFANQPDIALWNIAQFAMTLSSAKLITDKESNYVMERYGTKFMDDYQAIMTQKLGLPKYNKQLLSKLLNNMAVDKVDYTNFFRLLSNIKADPAIPEDELLIPLKAVLLDIGKERKEAWTSWVKFYIEELSSSGISDEERKASMNSVNPKYVLRNYLCQSAIDAAEMGDFEEVRRLLKVMERPFDEQPGMEKYARLPPAWAYRPGVCMLSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1B2</accession>
    <name>A0A068V1B2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00041104001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1B2"/>
    <dbReference type="STRING" id="49390.A0A068V1B2"/>
    <dbReference type="Gramene" id="CDP14575">
        <property type="protein sequence ID" value="CDP14575"/>
        <property type="gene ID" value="GSCOC_T00041104001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1B2"/>
    <dbReference type="OMA" id="QLNDYYI"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1B2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000002">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF57">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="238" mass="26453" checksum="BF2B547B4B1C78D1" modified="2014-10-01" version="1">MTIQQTGFISTYSALSEAAGVAGNFFAFVLFVSPVPTFRRIIRRQSTEQFSGLPYVYALLNCLICLWYGMPIISPGIILVATVNSVGAIFQMIYIIIFIAYAERGKKVKMLGLLLAVFAVFSIIICVSLKFFEPPNRQLFVGYLSVLSLISMFASPLFIINLVIKTKSVEYMPFYLSLATFLMSLSFFGYGMFKQDLFISVPNGIGGLLGIIQLVLYFCYSRSSDGGRPRAPLLESYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2D1</accession>
    <name>A0A068V2D1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00042261001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2D1"/>
    <dbReference type="STRING" id="49390.A0A068V2D1"/>
    <dbReference type="Gramene" id="CDP14801">
        <property type="protein sequence ID" value="CDP14801"/>
        <property type="gene ID" value="GSCOC_T00042261001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2D1"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="16971" checksum="E490F2F49A110C7C" modified="2014-10-01" version="1">MEVEHAELLQPFSPSGQYLRSSAISLSVIAVMESEISIDDSMAIPLLYDVFLPINPRFSSMTVGFLAFCSFSCQIGKLTENGNPDLFFCFFFISVLHETHIYCFLSSLSATSFLKILTIVTSKNFSKFLNYTFPKYSKKTLPTINIPFTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2Q8</accession>
    <name>A0A068V2Q8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00040403001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2Q8"/>
    <dbReference type="STRING" id="49390.A0A068V2Q8"/>
    <dbReference type="Gramene" id="CDP14158">
        <property type="protein sequence ID" value="CDP14158"/>
        <property type="gene ID" value="GSCOC_T00040403001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2Q8"/>
    <dbReference type="OMA" id="PEMDSTY"/>
    <dbReference type="OrthoDB" id="1902591at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2Q8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000227">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g13880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000196">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g14850"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000285">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001325">
        <property type="entry name" value="Tetratricopeptide repeat (TPR)-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="599"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="5">
        <location>
            <begin position="916"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP14158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112674" checksum="C9BD3DD21BBF2BAA" modified="2014-10-01" version="1">MVARFKQLQSKTLFLPPPLLSVRSLSSSCAAPRIIDYNNIATDSQFRNAKIPRFGSPDAPTKGSRNGGRNKEVPRFRLSNGSKRGPRNLDSPDLELLPMQRGIKRRIREDYLGGVDDDGGVVNLDRGKVLRWYSETFRYCAVNLCLNEGKVFHANLIKIGIDPDSHLFVSLINFYAKCGALSFARRVLDEMPEKDVVSWTALISGFVAEGLGQEGVELFCEMRREGIRPNEFTLATVLRACSMVSGLEFGKQLHAEVVKGEAFTDVYVGSALVDLYAKCGEMEYADKVFFIMPEQNAVSWNVLLNGYAQLGDGHKLLILFCKMTESDMRFSNYTLSTVLKGCASSRSLWAGQVVHSMAIKIGSAFDDFISCGLVDMYSKCELANDALQVFKMIRDPDIVTWSTMISGLDQQGQKLQAVELFRLMMQSGLRPNQFSLSTVVSTATDLGDPHFCKSIHACIWKFHFESDLSVSNALITMYMKLGLVYDGLKVFSAMSQKDVVSWNALLSGYHDGESSDQGPMIFKKMLTEGLMPNQYTFISTLRSCTSQLNASFGKQVHAYLLKNNLCTDVHVGIALIDMYSKCRCLDDVELIFNRLSERDIFTWTVLIAGYAQTDNQGEKALGFFNRMHREGVKANEFTLASCLSACAGIASLINGQQLHSWAIKSGHFCDVYVASALVDMYGKCGCIDDAEMIFKSIETVDTVLWNTMICGHSKHGQNEKALQSFGAMLNKDVQPNGVSFIGVLSACSHMGLVEEGKKHFHLMSELYGIAPSVDHYACMVDILGRAGRFSELESFIQHMKIAPNTLIWETVLGACKIHGNVEMGEKAAQKLFEIDPDEDSSYIWLSNIYAAKGRWNDVSRIRALMSSRGVKKEPGCSWVEVDAKTHVFLSQDASHPRLTDIYQKLEDLHQRLQSIGYTPNTHYVLHNVPDAVKKENLFHHSERLALAFALVSNANGGRIRIFKNLRICGDCHEFMKGVSDITNKEIVIRDSNRFHHFHNGICSCKDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3T3</accession>
    <name>A0A068V3T3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00043001001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3T3"/>
    <dbReference type="FunCoup" id="A0A068V3T3">
        <property type="interactions" value="1566"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3T3"/>
    <dbReference type="Gramene" id="CDP15316">
        <property type="protein sequence ID" value="CDP15316"/>
        <property type="gene ID" value="GSCOC_T00043001001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3T3"/>
    <dbReference type="OMA" id="YNEVFHS"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3T3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="151"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP15316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="232" mass="26265" checksum="EC0E2B6ABADDB3D6" modified="2014-10-01" version="1">MFKFWNSPDQQTQPRPQEISTGSWGPPSVVSSPSSSRPGTPSVSSSGSFSIQRPADRSQSSAHVSPSEAAGIIAHLKDKSVDELRKLLSDKDAYHNFLLSLEPVKTQNKVRDELRNETLQLASANLDKEPRIMELRNQCRIIRTTELAAAQEKLHELDRKKEETLKFYAPVSLLRQLQEAMSTAEEESEALHRQLLDREIDHGSFIQKYKKLRCTYHRRALTHLAAKTSFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V539</accession>
    <name>A0A068V539_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00015560001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP15634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068V539"/>
    <dbReference type="FunCoup" id="A0A068V539">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V539"/>
    <dbReference type="Gramene" id="CDP15634">
        <property type="protein sequence ID" value="CDP15634"/>
        <property type="gene ID" value="GSCOC_T00015560001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V539"/>
    <dbReference type="OMA" id="EHDHGSC"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V539"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02079">
        <property type="entry name" value="P-type_ATPase_HM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000022">
        <property type="entry name" value="Putative cadmium/zinc-transporting ATPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000043">
        <property type="entry name" value="Putative cadmium/zinc-transporting ATPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051014">
        <property type="entry name" value="Cation_Transport_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01512">
        <property type="entry name" value="ATPase-IB2_Cd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48085">
        <property type="entry name" value="CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48085:SF5">
        <property type="entry name" value="CADMIUM_ZINC-TRANSPORTING ATPASE HMA4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP15634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1102" mass="118903" checksum="B416DA6396DE2F0A" modified="2014-10-01" version="1">MVAHASASHGEDGEEKKIQKSYFDVLGICCPSEVPLIENILKSMDGVKDVSVIVPTKTVIVLHDSILTSQLQIVKALNKARLEASIRVQGVNSAQKKWPSPYAIASGVLLLLSFLKYFYYPFHWLALGSVAFGIIPIIFRALSALRNLTLGDINILLVITVAGSIVLRDYWEAATIVFLFTISEWLESLASHKATAAMSSLLNLVPQRAVLAETGEEVDVNDVKVNSVLAVKGGEIIPIDGVVVEGNCDVDEKTLTGESFPAIKQKDSNVWAGTINVNGYISIRTTELAEDCVVARMTKLVEEAQNNKSRTQRFIEKFAKYYTPAIVLMSAALAVIPASLRVHNQKQWYHIALVVLVSACPCALILSTPVAIFCALTKAAKSGVFFKGADYLETLANVKVMAFDKTGTVTRAEFEVTEFRSLLDDCSLSNMLYWVSSIESKSSHPMAAALVDLAQSHQVEPKPDKVEKFQDYPGEGIYGRIDGKEIYIGNSKISARAGCPSVPKLGGNIDEGKSVGYIFVGSTPAGIFSLADVCRTGAKEALKELKSAGIKTVMLTGDSYAAARHAQDQLGGALDAVHAELLPQDKAKIIEDYQKLAYTAMIGDGINDAPALATADIGISMGISGSALATETGHVILMTNDIRRIPKVARLARRVRRKILENMILSVATKGSIVALAIAGHPLVWAAVLADVGTCLLVILNSMLLLREKPKHQRKCCKSSAASALDNKQNKKCSGRDSLHILPCCSAIIPQEHCNVKSCCSRNSAPRHQSGPQSSSSSSCRSSKIADYTDKHSCCGNGKGIQMAKCSNLGSDNSDLEHIGELSTHQHGELSCSKSIKMLGKSLSPAKEDNGKSSESDLLHTHQPCCHAIKPQKQCEVDTCFSKNCAPTYQSGALSSSSRGSCKKSEFKNKKSCCERDKQARKPKCCNRGSCKGNTEHIGLSTHHHGESNCSESSKRHAFDDGVNEIEQCSSFNCKSCGSSVQDSQLSSKTEVEVKLCPDHPKDHITADEELGEPKRFCCGQDQGDNFQSLCKDHSADCSPPYQQTTTDILGGHNHVGCGAPRACLSKRHVGGCCESFRKECCVHGGHFEASFRGGLSEIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V665</accession>
    <name>A0A068V665_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anther-specific protein LAT52-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00017354001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ole e I family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739203">
        <property type="protein sequence ID" value="CDP16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V665"/>
    <dbReference type="FunCoup" id="A0A068V665">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16230">
        <property type="protein sequence ID" value="CDP16230"/>
        <property type="gene ID" value="GSCOC_T00017354001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V665"/>
    <dbReference type="OMA" id="ADCNEPF"/>
    <dbReference type="OrthoDB" id="1888725at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V665"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006041">
        <property type="entry name" value="Pollen_Ole_e1_allergen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31614:SF2">
        <property type="entry name" value="F28N24.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31614">
        <property type="entry name" value="PROTEIN DOWNSTREAM OF FLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01190">
        <property type="entry name" value="Pollen_Ole_e_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655477" description="Anther-specific protein LAT52-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17479" checksum="F2E6862843BC5D75" modified="2014-10-01" version="1">MAKAVAVVSALCFLALASLAHAQEAFTVKGRVYCDPCRVEFQTSLSKSIEGAEVELQCRVRENETVTVSQKAKTDAIGNYELSVQGDHEEEICEVVSVSSPSQECNVPFGENKARVLLTQNNGVQGTDRYANALGYKTAEANPDCKAVLQEMGYIPDEDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6Q1</accession>
    <name>A0A068V6Q1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Disease resistance protein At4g27190-like leucine-rich repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00018421001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739211">
        <property type="protein sequence ID" value="CDP16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6Q1"/>
    <dbReference type="Gramene" id="CDP16480">
        <property type="protein sequence ID" value="CDP16480"/>
        <property type="gene ID" value="GSCOC_T00018421001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6Q1"/>
    <dbReference type="OMA" id="CACSELE"/>
    <dbReference type="OrthoDB" id="1926275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6Q1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF187">
        <property type="entry name" value="AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="219"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="382" mass="42582" checksum="82950DFD9CD94F24" modified="2014-10-01" version="1">MHDLVRDMALRITNGNSKLKMKWTEDLHAVYFHTFGSAEIEVPPGWSPNCPKLSTLLLPHFSIKRIPDSFFRHMCGLKVLNLEGCKDITELPNCVSDMVNLTALILGGCARLMFVPPLGKLKQLRDLDLSCTSIQDLPQGWGSLVNLERLNLKKCQTLGLKIIPKGTFSQFHRLQLLLLPPFGKSLSPLRDLEQLGLSRLPNLVGLFYGGSEPYLLPVGTFSSLKILWIHECHNMKQLFTVQLLQTLQNLETLDIKNCEGLEEIAADGNGVGQGGGERIQLTSSGATATVILPKLRCLSLNRLPQLKNICKAAMICNSIKEIEIFDCPKVKRLPLFLPTTNGLPSPPSTLRKIRGDVEWWELLEWDSPYPKSALDPLFIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7R9</accession>
    <name>A0A068V7R9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00018932001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739215">
        <property type="protein sequence ID" value="CDP16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7R9"/>
    <dbReference type="Gramene" id="CDP16549">
        <property type="protein sequence ID" value="CDP16549"/>
        <property type="gene ID" value="GSCOC_T00018932001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7R9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="178" mass="20778" checksum="5F7B40D6ADA66859" modified="2014-10-01" version="1">MRNQTTLMTNSHHRNFDQLHFNQFDTQPFVNRGTTKPLDQIHTTSHNHFSRLFLCTNQSRNQFHSKYHSTLSFLIHNKTSFLPCLDREHRERERAAGNFLDSAVSWSKAREGNLPEASPILPSSTTLFSRNSKPESPSALGRELGRKFLEFRVKDWLLAEVLETESWMPIYVFLLDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8N4</accession>
    <name>A0A068V8N4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00011386001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739226">
        <property type="protein sequence ID" value="CDP17011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8N4"/>
    <dbReference type="FunCoup" id="A0A068V8N4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8N4"/>
    <dbReference type="Gramene" id="CDP17011">
        <property type="protein sequence ID" value="CDP17011"/>
        <property type="gene ID" value="GSCOC_T00011386001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8N4"/>
    <dbReference type="OMA" id="NDHFCES"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8N4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000022">
        <property type="entry name" value="Probable 2-oxoglutarate-dependent dioxygenase AOP1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="163"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="313" mass="35539" checksum="E672152223319FEB" modified="2014-10-01" version="1">MGSLAQHKLPVIDFTKKNLDPGSSSWLSTRQAVVGALEEYGCFIALYDKVSLELHEAIFRASEDLFDLPTETKLLNTCHKPAPGYVGQNPRFPLYESLGIDDATSIDGVQKFTTLMWPNGNDSFCESASSYSKLVAELDQMVMRMVSETYGVEKSYETLLGSTSYLLRLIKYREPQENETNLGIVPHTDKSFMSILQQHQVKGLEIKTKDGRWMEIDPFPSSFIIMAGEAFMAWTNGRIEAPHHRVIMPGNAERYSVGLFTFIWDLLIQVPEELVDVEHPLQFKPFDHHKFHQFHTTEEGMRSKCAIKSYCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAC1</accession>
    <name>A0A068VAC1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00006660001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739261">
        <property type="protein sequence ID" value="CDP17730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAC1"/>
    <dbReference type="Gramene" id="CDP17730">
        <property type="protein sequence ID" value="CDP17730"/>
        <property type="gene ID" value="GSCOC_T00006660001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAC1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="58" mass="6752" checksum="4C696E910C91DEF2" modified="2014-10-01" version="1">MQPREDHHRETWRAILLPCVSSFFISGVRSIIDSQKTIHMVTNPKSPFAEIKFHVNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAC5</accession>
    <name>A0A068VAC5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00011465001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739250">
        <property type="protein sequence ID" value="CDP17519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAC5"/>
    <dbReference type="FunCoup" id="A0A068VAC5">
        <property type="interactions" value="2649"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAC5"/>
    <dbReference type="Gramene" id="CDP17519">
        <property type="protein sequence ID" value="CDP17519"/>
        <property type="gene ID" value="GSCOC_T00011465001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAC5"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP17519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="80068" checksum="30F6A849423A5255" modified="2014-10-01" version="1">MQQLQRLQEKDPEFYEFLKEHDKELLDFNDEDVDDEAETDVDSEDIEEDAETDEYLMKHVPSVAVEAKSSKNVITTAMVDSWCKSIQENTSLGAVRALMKAYRTACHYGDDSGDDNANQLSIMSSSVFNKIMLFVLSEMDGILRGLLKLPPSGGKKETLLDLMSTRLWKNYNHLVKSYLGNSLHVLNQMTDTKMISFTLRRLRYSSIFLAAYPALLRKYVKVVLHFWGSGGGALPVVSLLFLRDLCLQFGSDCIDDCFKGMYKAYVLNCQSFTATKLQHIQFLGNCFTELLRVDLGAAYQHAFIFIRQLAMILRETTTRTKKNSKLSFKELFRKVYGWKFMNCLELWTGAICAYSSEADLKPLAYPLTQIITATARLVPTAQYFPLRLWCIKMLNRIAASTGTFIPVSLLLLEMLEIKELHRPPTGGVGEAVDFRTMLRVKKSALKTRAFQEMCVFSVIEELTEHLAQWSYSAAFFELSFVPTVQLREFCKSTKVERFRREMRQLIRQIEANCEFTNKKRMSVAILPNDPGAASLLEDEKMKGSSPLSQYATVLRERAQQRNDSITQSSVTVGERASIFGSKITDNDEQDDSVNEEGVTAFNSGWLPGSDSTTSHAEKVKEKRKRKRPQEEAAFDEDVVEELILSSDEDEDEDSMSNAQELEDTEEEPVISKRQKMSQQPLASLSNLSKKKRKYKSKKSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB68</accession>
    <name>A0A068VB68_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008279001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739289">
        <property type="protein sequence ID" value="CDP18075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB68"/>
    <dbReference type="FunCoup" id="A0A068VB68">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB68"/>
    <dbReference type="Gramene" id="CDP18075">
        <property type="protein sequence ID" value="CDP18075"/>
        <property type="gene ID" value="GSCOC_T00008279001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB68"/>
    <dbReference type="OMA" id="LYWSALM"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB68"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF53">
        <property type="entry name" value="PROTEIN ACTIVITY OF BC1 COMPLEX KINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="611" mass="68637" checksum="7C776CBF7E6A7449" modified="2014-10-01" version="1">MAAGNGKPSSAGNGNTALEQLDFERGVCIPFRKYSPQTVRDKVLESRGAILSLIGRGVEIVWKLGLYWSTLVYDYFVGRDEEVVPFRASQLRNLLCDLGPSFIKAGQVLANRPDIIREDYMNELCILQDDVPPFPDQVAFNIIEEELGQPLEAVFSKISSQTIAAASLGQVYRATLRASGEDVAIKVQRPEIEPIIYRDLFLFRTLASFLNGISLQKLGCNAELIVDEFGEKLLEELDYTLEARNIEDFLENFKDDPTVKIPGVYRQLSGSHVLVMEWIDGIRCTDPQAIKEAGIDIDGFLTVGVSAALRQLLEFGLFHGDPHPGNVFALRDGRIAYVDFGNVAVLSQQNKQILIDAVVHAVNEDYAEMANDFTRLGFLASGTDVSPIIPALEAIWQNSLEKGLADFNFRSVTGKFNQLVYNYPIRIPERFSLVIRSLLTQEGICLTLEPDFKFLEVAYPYVAKRLLTDPNPALRERLIQVLFKDGVFQWKRLENLIVLAKENVAKMSSNPALRGESRQRSKQWRIERKLDLTDTIKDGARLFLLDAGIRRQLLLALTEDSKLHIQELIDVYRLLEDQIDIPSVALEVAQDLPSVARDVMLSWSASVLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBV3</accession>
    <name>A0A068VBV3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00001634001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739283">
        <property type="protein sequence ID" value="CDP18049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBV3"/>
    <dbReference type="Gramene" id="CDP18049">
        <property type="protein sequence ID" value="CDP18049"/>
        <property type="gene ID" value="GSCOC_T00001634001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBV3"/>
    <dbReference type="OMA" id="EISQKCH"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBV3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF45">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="280" mass="31399" checksum="1B403BD1854ACA27" modified="2014-10-01" version="1">MVLDQAQRYRKTKGIIINTFLELESHAIHALSNDKTIPPVYAVGPVLNLKGSNSQNQETEMIMKWLDLQPKCSVVFLCFGSGGSFDGDQVKEIAYALEHSGYRFLWSLRTPSPKEKFEFPSEYENLDEVLPEGFLQRTATVGKVIGWAPQAAVLSHPAMGGFVSHCGWNSILESVWCGVPVATWPLYAEQQENAFLMVKDLAMAVEIKINFKRDFVMGVSSEILSADVIERGIKHLMDPENEIREKVKEMKEKSRLAPNEGGSSFSSLRRFLEDVADNIP</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
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            <end position="101"/>
        </location>
    </feature>
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            <end position="76"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="150" mass="16642" checksum="1372EF55041092C0" modified="2014-10-01" version="1">MNCVDDDTKETVTFRAVSRDEEGRKRAEKAEVDSYNVDTLKYIGKKLIDKGVQRQDRRPIDGIPLGRQHKSGHGGKRTWEGPSPCYLSPMAPPAIDENDPNYVDEEAEDRILRGEVSGVAGLVVGELELPKLAEEGVARIDVDPQLQTNI</sequence>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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        </location>
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    <sequence length="224" mass="24930" checksum="04EC42CDAA0BC172" modified="2014-10-01" version="1">MAISFFGLAIFLFLTLDSDFTSSPISTASAGIQITYGSVIKLMHERTKFRLHSHDVPYGFGSGQQSITGFPNIDDSNSYWIVRPVPDTNAQQGDTIKGGTIIRLQHMRTRKWLHSHLLNTTLLDYIRKSKVAASEARGITQGMGAYKVQVPFDGKPQTFVFLNTPRHEAFRAMRARGARVIDIAVIVVATDDGIRPQIEEAIAHAKAARVRIVIAINKVRLHLF</sequence>
</entry>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
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        <text evidence="1">May be involved in environmental stress response.</text>
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    <dbReference type="FunCoup" id="A0A068VDJ2">
        <property type="interactions" value="2335"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDJ2"/>
    <dbReference type="Gramene" id="CDP18642">
        <property type="protein sequence ID" value="CDP18642"/>
        <property type="gene ID" value="GSCOC_T00004131001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDJ2"/>
    <dbReference type="OMA" id="QCPNANQ"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDJ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000003">
        <property type="entry name" value="AN1-type zinc finger protein 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF27">
        <property type="entry name" value="ZINC FINGER AN1 AND C2H2 DOMAIN-CONTAINING STRESS-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP18642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31630" checksum="0200B58A49D1775D" modified="2014-10-01" version="1">MGTPAFPNLGKHCSVEDCRLIDFLPFTCDSCHQVFCLEHRSYGRHHCPKANKNDVTVVVCPLCAKGVRLIPDENPNITWESHVNIECDPSNYDKVTKKRKCPVSGCREILSFSNKIRCKDCTIEHCLKHRFGPDHRCPGPKKIESTFQFSSFLSSGKQQSKQNPVSSSSSWASSLFRVASSVRATAESGVARLSSDFKDILQGSGSSGGSSSTSHGGSTSGQVEQCPQCNLRFSSVMDLVNHVERVHERNGVMKVTLDVCPKCSKGFRDPVSLVEHVEREHRGTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEY9</accession>
    <name>A0A068VEY9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00011805001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739303">
        <property type="protein sequence ID" value="CDP18243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEY9"/>
    <dbReference type="FunCoup" id="A0A068VEY9">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18243">
        <property type="protein sequence ID" value="CDP18243"/>
        <property type="gene ID" value="GSCOC_T00011805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEY9"/>
    <dbReference type="OMA" id="QIDHCAM"/>
    <dbReference type="OrthoDB" id="671858at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEY9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34570:SF12">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34570">
        <property type="entry name" value="OS03G0593100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="139" mass="15609" checksum="193758E1B39BD1F0" modified="2014-10-01" version="1">MGRQDGDPAGAIVGPSIALLQERFKKLERIKEKRQMSTFSSISEAKRIIVPTNYNNDNNNSFSEDHHQMFLPSRPAAPFHQDPLSLGLNLNNKHADYRSLKSSGTTRPSFSALWSAHDKRGVKRPQKPDVSDVDTTLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFH5</accession>
    <name>A0A068VFH5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_511</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00003812001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739595">
        <property type="protein sequence ID" value="CDP19476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFH5"/>
    <dbReference type="Gramene" id="CDP19476">
        <property type="protein sequence ID" value="CDP19476"/>
        <property type="gene ID" value="GSCOC_T00003812001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFH5"/>
    <dbReference type="PhylomeDB" id="A0A068VFH5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF3">
        <property type="entry name" value="OS09G0267800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="540" mass="61525" checksum="EB70317D6A59EBA7" modified="2014-10-01" version="1">MHDMVHDVAKSIMSKSTRFINSETGSGDYSNQVRCLVIDSFGEGTINLLDSRSNLLHTLFLSQGSLSDDMLMKLKNLHVLNLSGEENQNLPISIGKLRHLRYINFEDSTSETLPESVCKLYNLQTLCLSYFLKVLPNGMCDLISLRHLHYYNDDKEFQMPLEMGRLTCLQTLRFFNVGREKGRQIGELGSLKNLKGRLEIRNLELVKGKEGVEEAKLSEKENLFGLELKWAREREGDNYNDEDVLDGLRPHPNLEELVIQHFMGDQFPRWLMDLPTTLPKSAITLPKLARLKFYSCDRCKELLPLQNFTSLKKLVIDECDGLTNLPGDMLYSCTSLQKLRVAYCDNLISFPLNLQQTPSLLELELYRCPKLKTCMMPKGFGFLTSLRELSIGPFSDDGDDHENSSIYNEFDWSGLISSSSSSSSSALRLLDLYGLPHMESLPHQIQHLTTLTSLLLRDFGGVKALPDWFGNFAALEYLCLLNFKELRHLPSEDAMRSLTKLKRLEVYGSPLLKERCTPESSGPDSQWSKVSHIQHLRIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFX0</accession>
    <name>A0A068VFX0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrator complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012426001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739340">
        <property type="protein sequence ID" value="CDP18593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFX0"/>
    <dbReference type="FunCoup" id="A0A068VFX0">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFX0"/>
    <dbReference type="Gramene" id="CDP18593">
        <property type="protein sequence ID" value="CDP18593"/>
        <property type="gene ID" value="GSCOC_T00012426001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFX0"/>
    <dbReference type="OMA" id="HEAENPI"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFX0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="482" mass="55682" checksum="A3290DCF1AF098AF" modified="2014-10-01" version="1">MRSKLTKNAIFEADNSLEVSLREAFQLLEPQLRPPFPLKLPTQEDYFNLNKAILCEILCEPHVARVHIKHLHAIVTDGYTYFISMLIKIVNELYAKLVDSVKTQLIWVTREMVNVLGVGFDGLLVALLRQIVGGDFSGGNLWLCFEMVSLFRDKWDCLLEDEPLVLTSALYVFLRLLADHCRLPNDSKVETLKRLEIDFCIRMLREKFGLCLKIGRDLVRLLQDLVHVPEFCSIWKDLLLNPSVFQTDAFLDIPQLYLSRTSSRYFLLRITPEMENQLRFLLTHVKLGNQKRYQVWFAKKFLGFPERETLLSDIVRFICCGHHPPNEIIQSDIIPRWAVIGWLLKSSQRNYVEANVKLALFYDWLFFDEKVDNIMNIEPGILLMINSIPSYVDITRTLLEFLLMLVENYDIERKDVIVKGVSSAFTFLVRKGVVQSLDALTCSDVISPFLKQLFEKIFKDMLASLSERAVASLPLKPISAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG50</accession>
    <name>A0A068VG50_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00004158001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739347">
        <property type="protein sequence ID" value="CDP18663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG50"/>
    <dbReference type="FunCoup" id="A0A068VG50">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VG50"/>
    <dbReference type="Gramene" id="CDP18663">
        <property type="protein sequence ID" value="CDP18663"/>
        <property type="gene ID" value="GSCOC_T00004158001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG50"/>
    <dbReference type="OMA" id="KHITHRC"/>
    <dbReference type="OrthoDB" id="938199at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VG50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053192">
        <property type="entry name" value="Vacuole_Formation_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410">
        <property type="entry name" value="CYSTEINE/HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410:SF216">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP18663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="40763" checksum="D37235FF1DC9A880" modified="2014-10-01" version="1">MTRDRILPQEDEEDLVQLPTNNFVQEMRHILEKKQGLEIMRVPKKVQVSCCQHTLAIVDIQKLIKSRNVERITCNRCIEPVVSLCCHCTQCNYFVHLTCAQLPEELQHPSHEKHKLKLAFVSYVWGMIKCSACNLDYNGYLFKCDTCRLYTFDHDVKCALLPSTIDHKAHEHSLVQMYRGNGNRCNSCGNVVRSFLYACEPCGFYLDYECALLPESVNHRWDKYALPLSFPPFSDRPDEFYCEICKEEIHPRRWHYHCRECDQSFHPRCIPGLGVTRNCNFGRILEFGRHPHPLKLVCDGEYRSTCDSCHERMYGNRVFKCETCQFYICIKYVARVANSGKIAGPAKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG67</accession>
    <name>A0A068VG67_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00000139001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739650">
        <property type="protein sequence ID" value="CDP19602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG67"/>
    <dbReference type="Gramene" id="CDP19602">
        <property type="protein sequence ID" value="CDP19602"/>
        <property type="gene ID" value="GSCOC_T00000139001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG67"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="65" mass="7965" checksum="5D26D4306D08782D" modified="2014-10-01" version="1">MFIKFSKFSVLENYLQLKVFSTCALNVTSSTFTPIRKGWYLKSLKKLIRKRWYLNMRDYELNYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH51</accession>
    <name>A0A068VH51_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00006890001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740016">
        <property type="protein sequence ID" value="CDP20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH51"/>
    <dbReference type="STRING" id="49390.A0A068VH51"/>
    <dbReference type="Gramene" id="CDP20140">
        <property type="protein sequence ID" value="CDP20140"/>
        <property type="gene ID" value="GSCOC_T00006890001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH51"/>
    <dbReference type="OMA" id="CLQWITS"/>
    <dbReference type="OrthoDB" id="1922547at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304:SF9">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7055" checksum="CBD85486F73BAA6D" modified="2014-10-01" version="1">MRMSCNGCRVLRKGCSENCSIKPCLQWIKSPESQANATVFLAKFYGRAGLMNLINAGPEHLRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ66</accession>
    <name>A0A068VJ66_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_616</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00003164001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739700">
        <property type="protein sequence ID" value="CDP19688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ66"/>
    <dbReference type="STRING" id="49390.A0A068VJ66"/>
    <dbReference type="Gramene" id="CDP19688">
        <property type="protein sequence ID" value="CDP19688"/>
        <property type="gene ID" value="GSCOC_T00003164001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ66"/>
    <dbReference type="OMA" id="WIPNEEM"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027728">
        <property type="entry name" value="Topless_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083:SF5">
        <property type="entry name" value="PROTEIN TOPLESS-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="223" mass="24247" checksum="C4694FFF217B7A85" modified="2014-10-01" version="1">MLITIFFVHDGTITGHHKQITGLAFSQNLNVLLCIWNIDGWEKKKMKAIQAPPGHTSPLIGETKVQFRNDQCHLLVSHESQIAVYDTQLECLNSWYPRDALSASISSAIYSCDGLLVYTGFLDDAIGIFDADSLRLRCWIAPSTYMPSSIVSGSGEIFPMVIAAHPSDPSQFALGMSDGAVHVIEPSDTEPKWGSLSSQDNGTLPTNPSSSALNSQPSETPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK23</accession>
    <name>A0A068VK23_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_2379</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00008232001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG741463">
        <property type="protein sequence ID" value="CDP21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK23"/>
    <dbReference type="STRING" id="49390.A0A068VK23"/>
    <dbReference type="Gramene" id="CDP21051">
        <property type="protein sequence ID" value="CDP21051"/>
        <property type="gene ID" value="GSCOC_T00008232001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK23"/>
    <dbReference type="OrthoDB" id="939809at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK23"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="129" mass="14997" checksum="8EEEB176F9162DB2" modified="2014-10-01" version="1">MDPRKRITAAEALEHQWLKKGGEASDTPIDSVVKIRMKQFRAMNKLKKLALKVIAENLSEEEIKGLRQMFNNMDMDRSGTITYEELKTRLSRLGSKLSEEEIHELMEAISNPRLWRRFLVLTHTWGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK27</accession>
    <name>A0A068VK27_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00009221001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741482">
        <property type="protein sequence ID" value="CDP21056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK27"/>
    <dbReference type="STRING" id="49390.A0A068VK27"/>
    <dbReference type="Gramene" id="CDP21056">
        <property type="protein sequence ID" value="CDP21056"/>
        <property type="gene ID" value="GSCOC_T00009221001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK27"/>
    <dbReference type="OMA" id="SPDRYWN"/>
    <dbReference type="OrthoDB" id="654134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK27"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF2">
        <property type="entry name" value="BURP DOMAIN PROTEIN RD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656019" evidence="1">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="BURP" evidence="2">
        <location>
            <begin position="90"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="308" mass="34387" checksum="6DA0EDE05E98B34F" modified="2014-10-01" version="1">MDLLKLLYFLTLVSTGVGAKHADLEVYWKSKLPNSPMPKALRDIVRNGKPPGVGSFSVRPDRIPLKIYKYIAHYSPTEDQLHYHQKVTAFFLKKDLHRGSSVNMQFIESVNDTPAFLPRQVADSTPFSSKSVPEILNKFSVNPHSAQAEAIKKTIAECEEPAIEGEDKYCATSLESMVDFTTSKLGKNVLAFSNEAPKNAGKIQKYGIVDVSKLNNDKAIVDDELVACHKQNYVYAVFYCHSFQNIDAYMVNLVGSDGAKVKAVVVCHKDTSSWDPRHLAFQLLKVKPGTVPICHFLPGDHIVWVPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKW3</accession>
    <name>A0A068VKW3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_1092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00006077001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740176">
        <property type="protein sequence ID" value="CDP20313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKW3"/>
    <dbReference type="STRING" id="49390.A0A068VKW3"/>
    <dbReference type="Gramene" id="CDP20313">
        <property type="protein sequence ID" value="CDP20313"/>
        <property type="gene ID" value="GSCOC_T00006077001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKW3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKW3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052306">
        <property type="entry name" value="CYP450_71D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953:SF16">
        <property type="entry name" value="CYTOCHROME P450 71D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953">
        <property type="entry name" value="OS08G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP20313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="247" mass="27938" checksum="7B74183CCE7F1EAD" modified="2014-10-01" version="1">MATGESGNEDLIDVLLRVKESGDLQFPITNNNIKAIVIDVFSAGTETSSTTVEWAMSEMVRNPNVMAKAQSEIRTAFKGKKKIEETDIQELKYLRLVIKETLRLHPPGPLLVPRECREECEIEGYTIPVKTRVLINAWAIGRDPDYWNDPESFKPERFKSNPVDFTGTHFEYLPFGAGRRMCPGISFGLANVHLPLALLLYHFDWKLPDGLDPCDLDMSETVGITASRKDSLRLLATSYDPYLQKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMM6</accession>
    <name>A0A068VMM6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_8193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00000759001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG747277">
        <property type="protein sequence ID" value="CDP21951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMM6"/>
    <dbReference type="STRING" id="49390.A0A068VMM6"/>
    <dbReference type="Gramene" id="CDP21951">
        <property type="protein sequence ID" value="CDP21951"/>
        <property type="gene ID" value="GSCOC_T00000759001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMM6"/>
    <dbReference type="OMA" id="MLILPRH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP21951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="78" mass="9437" checksum="CDC4A56395C59A04" modified="2014-10-01" version="1">MSASFLDEVLEVTGKFFKLPLDEKRTYSRDENRIDGYGNDVIYSDRQILDWNDRLYLHVLPESIRKCKKWPRLPQNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN93</accession>
    <name>A0A068VN93_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00006535001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG751246">
        <property type="protein sequence ID" value="CDP22210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN93"/>
    <dbReference type="STRING" id="49390.A0A068VN93"/>
    <dbReference type="Gramene" id="CDP22210">
        <property type="protein sequence ID" value="CDP22210"/>
        <property type="gene ID" value="GSCOC_T00006535001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN93"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="110"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP22210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="338" mass="39698" checksum="6019F599E420DB0F" modified="2014-10-01" version="1" fragment="single">EKSTDFTFGFWFDESEYVRRQEETKMLEMLFPFMTLLPSFQEDLHMSEFLPFEKNSTLPSRILSWMQSAEPKVTPLPVVILQECLIAYIKKQADYIGWIILSKLLYDWRLLDELEVLRAIYLLGSGDLLQHFLVVIFNKLDKGESLDDDFELNTILQESIRSSADGSLLSTPDSLVVSITKNSDLSEDEQHGASIQISTPRKSRLQTMGIDVLQSLNFTYKVSWPLELLANVEALKKYNQVMIFLLKVKRAKFVLDKARRWMWKDRSTATTTRKRHWLLEQKLLHFVNAFHQYVMDRVMYFTALFSTLTTFRVWFLYYLHIKMDRAFIFVGGYVIEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLM0</accession>
    <name>A0A068TLM0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014454001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Rouard M."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
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                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="300" mass="33534" checksum="C4FD0F3C25D1FF19" modified="2014-10-01" version="1">MSDGGSQDNFLWDNEVWALSNSDNSGRSDENQPAKKFSESNNSNCPTPREAEPRVGPSLGKRKRKNGKQPSVEGNDQAAEGKGGAGADHELHIWTERERRKKMRSMFSNLQSLLPQLPPKADKSTIVDEAVNYIRSLQQTLQRLQKQKLEMIRGLTTINYDPSMITPHRLAMDSREAFLADQGSSSQLSSNPNPLGVARFPTSFRTWATPNMVLNVCGDKAHINICCPKKLGLFSAICYFLEKHKLEVVSAHVSSDNYRSLYMIQAQASGAVDHQYPEAFSFDDIFHLATGEMMMYMSSL</sequence>
</entry>
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        <name type="common">Robusta coffee</name>
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            <taxon>Gentianales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="entry name" value="ZINC FINGER PROTEIN GIS2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="9"/>
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            <end position="62"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="164"/>
        </location>
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        </location>
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        <location>
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            <end position="222"/>
        </location>
    </feature>
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        <location>
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            <end position="243"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO96994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="254" mass="28195" checksum="8C2FFDC75900703D" modified="2014-10-01" version="1">MSSDSRSRSRSRSRSPMDRKIRTQRYSYRDAPYRRESRRGFSQSSLCKNCKRPGHFARDCTNVAICHNCGLPGHIASECTTKSLCWNCREPGHMAGNCPNEGICHTCGKAGHRARDCTAPPMPPGDLRLCNNCFKQGHMAADCTNDKACKNCRKTGHLARDCQNDPVCNLCNISGHVARDCPKGNIFDERGGGPRIGGGVGGGYREIVCRNCQQVGHMSRDCMALMICHNCGGRGHLAYECPSGRFMDRFPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM47</accession>
    <name>A0A068TM47_COFCA</name>
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        <recommendedName>
            <fullName evidence="6">DUF936 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014555001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM47"/>
    <dbReference type="STRING" id="49390.A0A068TM47"/>
    <dbReference type="Gramene" id="CDO97276">
        <property type="protein sequence ID" value="CDO97276"/>
        <property type="gene ID" value="GSCOC_T00014555001"/>
    </dbReference>
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    <dbReference type="OMA" id="DSTHSMY"/>
    <dbReference type="OrthoDB" id="773154at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="entry name" value="DUF6857_pln"/>
    </dbReference>
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        <property type="entry name" value="DUF936_dom_pln"/>
    </dbReference>
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        <property type="entry name" value="DUF936_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928:SF12">
        <property type="entry name" value="DUF3741 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31928">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6857" evidence="3">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6857" evidence="3">
        <location>
            <begin position="429"/>
            <end position="682"/>
        </location>
    </feature>
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            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="76801" checksum="1193AC7AEDED4EE8" modified="2014-10-01" version="1">MALLKSGVLEKHLQELKDEDQTLGDDRKPVLLQIRSIIPVLEEGDLFPDRGFYLKVSDASHAMYVSLPQEQNDMILSNKLKLGQFIYVHKLEKSEPVPLIRGLTPVPGRRPCEGSPEDIHSPTALVKFLQVLDTDPVVEKGVISEKTINEDSTISRKPLYRGLSDSEGLIRNHNGLQQRPRGRFRSLSASRTRHGERTVGSRSSKPTSTDDDSDSDSTLSSVSLMSKRKSWTQSDILGLKQMFDSSAIKNESKPVAKSLSANVSPVRSMRYDSSDECSSSTTRRRDVSSTKKLVKGTNKSRTPVPKVISEQTSQPVSSLVHDGKGAETAIAWESLPSKLVKLGKEVVRQRDIALSAAADALQEACAAERLLNSLSQLLENILFFSKRVEIQCTKMIFEVKHITYDVKQIFYALHFQNYDWKNDFIAQNTYSEFHVSGEEDVQPYVDKFFDLQDDLARTRLIVQSLTNISPFKTPETDANGTTSVKEALNIALERKKNATTWIKSAVAFDLSTCSSDPLKLSVSPVAATDAVKKPSRCVKPKGARIIRRQRTNDDLPLLVASDKDYQAEWTRGSTLCAAADLASLLQDECRKLLLSYVENYLEEVESKTSSMHSDRQVSGMMYKVKRVNDWLNVFIGKEPNLPGDDGFKIFSNLDDSEREAYGRVRNKIYEILLNHVERTALAFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM52</accession>
    <name>A0A068TM52_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00014561001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDO97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068TM52">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TM52"/>
    <dbReference type="Gramene" id="CDO97281">
        <property type="protein sequence ID" value="CDO97281"/>
        <property type="gene ID" value="GSCOC_T00014561001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM52"/>
    <dbReference type="OMA" id="NYHPRGF"/>
    <dbReference type="OrthoDB" id="1920561at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM52"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36364">
        <property type="entry name" value="OS03G0203000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36364:SF1">
        <property type="entry name" value="OS03G0203000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="38208" checksum="F28B4005974C270F" modified="2014-10-01" version="1">MSRREGRDSESRRHRSRFDEEPPSPKRSRRDGKPETERPPANSHLDNRDHSDRDQKHRRRLQDALPLEASSEQDSKVGGAALSKEKSDKASLDHEGTKVSLDPKDIPRSRSYFQHDDRGNAGQVGRSFGRRAATERGWWRDSKEQQSERGNRISTGDVQKKDDRAPRVHGEVNDAWRHDKYFQVEADPKQPAKKRSFREQKDQDDSGKAGKEVEELLKPNPEENPVSESARRDERGGYTSRHSGRPEQGFAGDREANKGDAWRSHFSTRDRYGNRTGNYRGRDRFTARQGYRATTRGRVEKWKHDLYDEANRSPSPKNEEDVVAKVEALLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMZ3</accession>
    <name>A0A068TMZ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014645001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMZ3"/>
    <dbReference type="FunCoup" id="A0A068TMZ3">
        <property type="interactions" value="1881"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMZ3"/>
    <dbReference type="Gramene" id="CDO97329">
        <property type="protein sequence ID" value="CDO97329"/>
        <property type="gene ID" value="GSCOC_T00014645001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMZ3"/>
    <dbReference type="OMA" id="WWIRFFS"/>
    <dbReference type="OrthoDB" id="745247at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMZ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045488">
        <property type="term" value="P:pectin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044689">
        <property type="entry name" value="CGR2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34208:SF5">
        <property type="entry name" value="OS01G0144000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34208">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28637" checksum="9C7FB4C708656F0D" modified="2014-10-01" version="1">MSRRPNTSRRLGDGGSIPFVGSLHPKARPSPSLSVGLLVVGAFLIIGYLYHGSGGRSADIDALNRLEGGASCALEVQRALPILKKAYGDSMHKVLHVGPETCSVVSKLLKEEDTEAWGIEPYDLEEADGYCKSLVRKGIVRVADIKFPLPYRPKSFSLVIISDALDYLSPKYLNRTLPELARVSADGVVILSGFPGQQRAKVAELAKFGRPAKLRSSSWWIRFFVQTSLEENEAAAKKFEQAAAKKSYKPSCQVFHLKSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPL2</accession>
    <name>A0A068TPL2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021938001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DH200</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPL2"/>
    <dbReference type="FunCoup" id="A0A068TPL2">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPL2"/>
    <dbReference type="Gramene" id="CDO97982">
        <property type="protein sequence ID" value="CDO97982"/>
        <property type="gene ID" value="GSCOC_T00021938001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPL2"/>
    <dbReference type="OMA" id="LCIRKHR"/>
    <dbReference type="OrthoDB" id="1928184at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPL2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34945">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34945:SF8">
        <property type="entry name" value="DOWNSTREAM TARGET OF AGL15-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="5">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="375" mass="42271" checksum="FFAE05CD77D0823E" modified="2014-10-01" version="1">MKKALMSTPESLPDNNIIDFRAPPPSPVASGRRSSFNNEDALSEFLENSLKVPDLVLPDRVFPQQKSVQNPPKLDFRSLNSTENDSVTKFVDSVARIGCFEVVNHGVPEGLIKSVLAAGAGIFGISQEKRKLVTRSLEKPYGFEEFHGEEEKAVTEEFVWSQDESLKMDMEGIWPAGYSNFSERMQKLVLAIENVAVTALEFLEQNTSTITRENVKQDPEFGPICYLHKHNGHIINGDQSVNSVLRYDVIRMLVRGSEFPHAICLHICDGAEEFHVYSKKGWASFCPDQGTIIITTGDQLQASGKGPYKHVMGRPIFRGADQERMSMVFPYPSVILKCDKHHKEQKISICWQFIATLILTLFFHFAVRLQSHARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ33</accession>
    <name>A0A068TQ33_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00022007001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ33"/>
    <dbReference type="FunCoup" id="A0A068TQ33">
        <property type="interactions" value="2866"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ33"/>
    <dbReference type="Gramene" id="CDO98034">
        <property type="protein sequence ID" value="CDO98034"/>
        <property type="gene ID" value="GSCOC_T00022007001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ33"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000295">
        <property type="entry name" value="Ras-related protein Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO98034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23172" checksum="0D4482A853E0313F" modified="2014-10-01" version="1">MASRRRMLLKVIILGDSGVGKTSLMNQYVNRKFSNQYKATIGADFLTKEVQFEDRLYTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNVMKSFENLNNWREEFLLQASPSDPENFPFIVLGNKVDIDGGNSRVVSEKKAKAWCASKGNIPYFETSAKEGYNVEAAFQCIAKNALKNEPEEELYLPDTIDVAGGQQQRSTGCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR37</accession>
    <name>A0A068TR37_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00025681001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR37"/>
    <dbReference type="STRING" id="49390.A0A068TR37"/>
    <dbReference type="Gramene" id="CDO98765">
        <property type="protein sequence ID" value="CDO98765"/>
        <property type="gene ID" value="GSCOC_T00025681001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR37"/>
    <dbReference type="OMA" id="TMGPDPK"/>
    <dbReference type="OrthoDB" id="1903759at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR37"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000003">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000007">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000058">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590">
        <property type="entry name" value="OS03G0124300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590:SF5">
        <property type="entry name" value="OS04G0586500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0278">Fertilization</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656999" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="24"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="527"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDO98765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="859" mass="95010" checksum="950F690B07E7F685" modified="2014-10-01" version="1">MIFDIHVLFLGIACSFIVNKVHSASNSNISNSDSLVLACGAPTNATDNNGRSWIPDSKFLASSDNSIVATALSQDPSLPSTVPYMTARVFQSQFTYTFRISPKARHWIRLHFYPSSYNNLSSSNGFFSVTADGFTLLNNFSALITAQALTQAYIIREYNIVPIQTGILNLTFTPSPAYNGSFAFVNGIEIISTPELFQAAPLVGFSEQSVEVEQNTVQTLIRLNVGGQYIPASDDSGLSRTWYDDSPYLFGAAFGVTSQADENVRINYPTGLPEYIAPVNVYDTARSMGPDPKVNQNFNLTWVFQVDPNYTYLVRFHFCDYQMSKVNQRVFAIFINNQTAFPDADVIGWASAKGVPVYKDFTIHVSDRSGDEQLWVALQPNQTSVPEFYDVILNGLEIFKINDTKGSLAGPNPVPSPLATPMESEPKQFAPSKSRKTGLILGAVGGAAVGFALVIGFVAFLRRRKRMALGESSSIAGWLPIYDSSRSSETGTTISGKSCGSSRISNIGGSLCRRFSLAEIKNGSMNFSESQVIGVGGFGKVYRCFVDGGTEVAIKRANPSSEQGVHEFRTEIDLLSKLRHRHLVSLIGACEEHNEMILVYDYMANGTLREHLYKTKKPRLLWRQRLDICIGAARGLHYLHTGAKYTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPTLHQTHVSTMVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLCGRPALDPNLPKEQVSLADWALRCHSRGVLDDIIDPCIKGEMAPECLKHFAETAAKCLSDQGIDRPSMGAVLWNLEYCLQLQNNPDGPEFVVQQKANDAYAMHETLLTIEENDKISQETEDSSSNEIFSQIINPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRC5</accession>
    <name>A0A068TRC5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022715001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRC5"/>
    <dbReference type="Gramene" id="CDO98572">
        <property type="protein sequence ID" value="CDO98572"/>
        <property type="gene ID" value="GSCOC_T00022715001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRC5"/>
    <dbReference type="OMA" id="DMYIKNH"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000381">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001681">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g33170 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF349">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67864" checksum="B0F3603952FFA467" modified="2014-10-01" version="1">MHNFLRSLQSTRLLELSSIAIIRSKILSSNHTYCSITINGPVGSKDDEDAYVSILRKCIDASNLRNAKAIHAKIFKGDICGSSWLFLGNHLINAFAKCGETCDALQLFDEMPQKNVVSWTALIAGFEQKGLSAESFSLFKQMGASGMRANEFTLVSALHACSAADFLGVVHVYQVYGLIIRLGFESNVHLLNAFLVALMRHRRLSEAFEVFEESHHRDIVSWNTIIGGYLQLSCREIPGFWVRMISEGIVPDGFTFASVLTGLAELLDFEMGVQVHGKLVKSGHGSEMCVGNALVDMYLKNRKLVEGFKAFEEIPLLDVSSWTQMAIGCLNCGEPNVALKVIGEMRRKGVKPNKFTLATAFNVCANLTSLEEGEKIHGLRIKLGHDVDVCVENALLDMYAKCGCMSSALKVFRSMDEWSVVSWTTMVMGFAQNGCAKEALEIFDEMRLKRVEPNCITFICALYACSQGGFVNEGWSYFSSMSSQYGIDPGEDHYACMVSLLGRSGCIKEAEELIHGMPFKPSLLIWQTLLGACRLHGDNETAKRAAEHALHLDKTDPSAYVLLSNTFASSNNWDSVGILREVMESQDVKKMPGSSWIELDRNESVTKSHRVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS72</accession>
    <name>A0A068TS72_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00025853001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS72"/>
    <dbReference type="FunCoup" id="A0A068TS72">
        <property type="interactions" value="2094"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TS72"/>
    <dbReference type="Gramene" id="CDO98897">
        <property type="protein sequence ID" value="CDO98897"/>
        <property type="gene ID" value="GSCOC_T00025853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS72"/>
    <dbReference type="OMA" id="MGECYYY"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF36">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62814" checksum="E056005BA2EE23B0" modified="2014-10-01" version="1">MDHYVPKDQVTTLLDHGLFTSAQLLGGFLVSSSTGNSEASPQLKAESLVLLGDSFFKEKEYRRAIHTYKQALLHLKTILKPTATTSRSSLSASNRSSSPSSFNNSAINENEVKFRIASSYCALNENRAALIEMEGIPSKAKTLQMSLMMGKLYRYTRHTRAAAACYKECLRQCPYIIEAIIALAELGLSAKDIISLFPQTPSRSARAPFDHLESSRWLQRYVEAQCCIASNDYKGGLELFSELLQRFPNNIHILLEMAKVEAIIGKIDEAIMNFEKVRSIDPYVVAYMDEYALLLKTKSDQSKLNKLVHDLLNIDPTRPEVFVALSVLWERKDDRGALSYAEKSIRIDERHVPGYIVKGNLLLSMNRPDAAAIAFRGAQDLRADLRSYQGLVRSYLALSKIKEALHAAREAMKAMPQSAKALKLVGDVHASSTTGREKAKKFYESALRLEPGYLGAALALAELHVMEGRNGDAVSLLERYLKDWADDSLHVKLAQVFAATNMLQDALLHYQAALRINPQNEAAKKGLERLEKQMKGVDPDAPEEDEENDVEDVDGDVEENELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSB5</accession>
    <name>A0A068TSB5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022233001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSB5"/>
    <dbReference type="FunCoup" id="A0A068TSB5">
        <property type="interactions" value="1053"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSB5"/>
    <dbReference type="Gramene" id="CDO98213">
        <property type="protein sequence ID" value="CDO98213"/>
        <property type="gene ID" value="GSCOC_T00022233001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSB5"/>
    <dbReference type="OMA" id="MAWLIRP"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSB5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000003">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF36">
        <property type="entry name" value="OS08G0439900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22534" checksum="A7755968ACD328FD" modified="2014-10-01" version="1">MRKEAFEGNILRLLRNETQYELDHSPPSRPIPEFHLFTVDERPGEQWIRLKKKFGETEEIKVDVTMFDVSIPKKKPGGVVTEDDVQLRVTMIVNICKGEGVDVLEFVCSAWPDTIEIRKVYARGQKQITSPPYMGPEFKELDDKLQDSLYDYLEIRGINDDLAAFLHSYMKNKDKTEFIRWMGTVKSFVEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSI5</accession>
    <name>A0A068TSI5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00026020001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSI5"/>
    <dbReference type="FunCoup" id="A0A068TSI5">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSI5"/>
    <dbReference type="Gramene" id="CDO99017">
        <property type="protein sequence ID" value="CDO99017"/>
        <property type="gene ID" value="GSCOC_T00026020001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSI5"/>
    <dbReference type="OMA" id="WNQEIQE"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSI5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000382">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="82"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="564"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO99017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="702" mass="78233" checksum="68F8AF31FB485826" modified="2014-10-01" version="1">MQDFIGSVRRSLVFKPLTGGDSPDNNGTIANGFNGFVEKIGSSIRKSRIGIFSKPQVPSLPPIAKSEPVKVRKDESKPQIRWRKGELIGCGAFGRVYMGMNIDSGELLAVKEVSIAANSASKERTQVHIRELEEEVNVLKNLSHPNIVRYLGTAREQESLNILLEFVPGGSISSLLGKFGSFPESVIRMYTKQLLLGLEYLHKNNIMHRDIKGANILVDNKGCIKLADFGASKKVVELATMTGAKSMKGTPYWMAPEVILQTGHTFSADIWSVGCTVIEMATGKPPWSQQYQEVAALFHIGTTKSHPPIPEQLSAEAKDFLLKCLHKEPNLRPSASDLLKHPFVTGEYEGTHPVFRHSIMLDNSGNWIAATRMDITKSTKFDPWVSSNGLKDACTMSGVRRSTMYPEKFSGQGSVWKSGNFDDDMCQLDDKDDLLMVGSSMKSYNSEFHSKDFNKSFNPICEPEDDWPCKFDESPELERHRTSLLASQAIQYPGNSVELSSKKDGGFTFPVGQLVADDEDEVTESKIRAFLDEKALELKKLQSPLYEEFYNSLNAASPVSPVATENKENVSDNLNLPPKSRSPNRLPSRRLSAVVDNTNSCSPESRSKRSSNIGGLNHQVSHDAQSSQLRELKGLLFDSQREPPSPSASFSERQRKWKEELDEELKRKREIMRQAGVVKTSSPKDRIVHRFKDQLRYASPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTF8</accession>
    <name>A0A068TTF8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029221001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="1">
        <location>
            <begin position="309"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="435" mass="49514" checksum="F17A952660FC463F" modified="2014-10-01" version="1">MGIFKLKLSQLLVSLVLIVLLAYNSLSIFSVYIPFPAKTAPLLASSSPENVAEKSRRFVSMSSSGKVSSSVMYAVKEEIPVAEKKTLLDLNFTILHTDQNSLDFIRNESVILHVKRRQSRKALSKIFGQDGEMKQFSKRVKEFFKANSSNSSCKFRFFMTWISSIGNFGDREFFTIESLFKSHPDGCLIIASDSLDSRLGMEILRPFLKKGFRVAAVSPDYSYLFKNTVAKAWIDRLTKGNVNPGEVSFGQNLSNLLRLGLLYKFGGIYIDADMIVLKRFVNLRNAIGAQTVNLQTRNWSRLNNAVMIFDKGHPLLYKFIEEFALTFDGNKWGHNGPYLVSRVVSRVSQRPGYNFTVLPPAAFYPVDWSRIGSLFRAPRNETQSKWMFTKLREIRGRSFAVHLWNKESRKLEIQQGSIIQHMMSDTCIFCNFTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTK0</accession>
    <name>A0A068TTK0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026528001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDO99377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068TTK0"/>
    <dbReference type="Gramene" id="CDO99377">
        <property type="protein sequence ID" value="CDO99377"/>
        <property type="gene ID" value="GSCOC_T00026528001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTK0"/>
    <dbReference type="OMA" id="ETDEYFW"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47759">
        <property type="entry name" value="OS04G0509100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47759:SF2">
        <property type="entry name" value="TRIGLYCERIDE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="124"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="883" mass="98617" checksum="CB6BEF181758C893" modified="2014-10-01" version="1">MAGLQLHLYFLHSAHTPKGPKLLHFKNPVSLSYARKLLFHKRISGFLDSSYFRAKSVNGPHLLCCFSKGNAENETVLAKEQESESENERPPFDINLAVILAGFAFEAYYTPPENIGKREVDGAKCQTVFLSKSFMREIYDGQLFIKLKKGINLPAMDPWGTSDPYVVIQLDSQVVKSKTKWGTKEPTWNEEFALNIKQLPNQILQIAAWDANIVTPHKRMGNSGINLDSLFDGDLHEVLIDLEGMGGGGQIELEIRYKSFEKIDEEKQWWRIPLVTEFLEKYGIENAVKKVFGSETVQARQFVEFAFGQIKSLNNEYLPNNWFSNSRVGNRYISDPSAESDMTPQLESRSEFSSNDRIDEVVENETGNNTENSGVDDGKNSLTIDQVGETLESDKQFWHKLTETVNQNVVQKLGLPAPNIIRWDTFDLLNKIGLQSRKIAEAGYIESGLATPENLESGNGDANTGPISPDTDQSSFSNMKRVTQDLLQQTDAVLGALMVLNATVSEISKRSGLLGKQDDKTDASTESSEPSASPPDGLVLDEEKAEEMRALFSTAESAMEAWAMLATSLGHPSFIKSEFEKICFLDNPSTDTQASQYSSVGYCLVVALWRDSARKRLVVAFRGTEQARWKDLRTDLMLVPAGLNPERIGGDSRQELQVHSGFLSAYDSVRTRILRLIKQVVGYNDDDFQPLSKWHVYVTGHSLGGALATLLALELSSSQLAKHGAICVTMYNFGSPRVGNKKFAEVYNKKVKDSWRVVNHRDIIPTVPRLMGYCHVAQPVYLAAGDLENALENMSLMADGYQGDVLGESTPDVIVNEFMKGERELIEKILNTEINIFLSIRDGSALMQHMEDFYYVTLLENVKSNYQTVATSQSNEEKSVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU74</accession>
    <name>A0A068TU74_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00029536001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU74"/>
    <dbReference type="FunCoup" id="A0A068TU74">
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657319" description="Nucleoside phosphorylase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO99840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="339" mass="36812" checksum="AC6DA25B2D68E652" modified="2014-10-01" version="1">MAGNQVKWLLLMLVFVSSLIAVSSERKTISASRTFKELNRNGPYLGLITVFAPEEDAFFATGAFKPNPKHPYVDLSGRRFRVGSIGGSKVIYVRCGEGMVNAAAATQQMLDVFRVIGIVHFGIAGNANNSMSIGDVIIPKQFAQTGLWDWVKFKATIPTNDVAELDFGSYDVPNGGDNELGSIGYSTEFFYSKSGKPNAPERTLWFQTSQNWLEVSSSLEGMALEQCVNSSLCLPEKPKVVVGLNGATANIFVDNAAYREFLYTTFHVSSLDMESAAVVMTCLSNGFKVIVIRGLSDLAGAQDGDNTIRLFGPLAASNVAKAVVQFVKTLRGFHFQLSI</sequence>
</entry>
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    <accession>A0A068TVL3</accession>
    <name>A0A068TVL3_COFCA</name>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00029756001"/>
    </dbReference>
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    <dbReference type="OMA" id="HIANSSC"/>
    <dbReference type="OrthoDB" id="1925835at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVL3"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007142">
        <property type="term" value="P:male meiosis II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="JASON"/>
    </dbReference>
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        <property type="entry name" value="ASPARTYL/GLUTAMYL-TRNA(ASN/GLN) AMIDOTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33318:SF22">
        <property type="entry name" value="SUPPRESSOR PROTEIN SRP40-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="486"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54215" checksum="F3F033BA97018419" modified="2014-10-01" version="1">MGCFFACFGSSKKHHKTKKPESLTSPKNQNLNESHEVNEALICSNQADEEGAEIADPIEVIPEIKGKNEEQVSTSFGKKVTFDLLLKAPEECQAQEGALENDQKRKKRDESRPEVILDFPSSSEKKEGKAKKEESKDEADLLSDSTISSLFTYPPNHRYQNCESSDDECVDMGLKKNNPEDEEDDGKSDDDMDGNYEEKNGSEDSVDIQEESSELFSISIEYKKQSSAVERDEKEVSSPLKPAPDREINKPNARDRTQYVHPVLNPIENLGQWKAVRAKTTSSLEHQEKENLNLVQEFTIPCAEKENSSLTSKNPIPFSEEPNPNQSQQQRSKRFSNRLRHDEVAVDTSLSSWLMESDKTPPDGNSPGSVGNSAPKKTESPTSFEDRPILGVLTVEDLKQMSKSATPSPRRSPRHSPDEMPIIGTVGSYWRHTREARAADTRSPGKGTSVTSCTTSRECRKGGMNGHHTPFQARLERTLDGATVQV</sequence>
</entry>
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    <accession>A0A068TZB9</accession>
    <name>A0A068TZB9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036459001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZB9"/>
    <dbReference type="Gramene" id="CDP01417">
        <property type="protein sequence ID" value="CDP01417"/>
        <property type="gene ID" value="GSCOC_T00036459001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="67" mass="8214" checksum="A1F1987111AE159B" modified="2014-10-01" version="1">MFFTFNHKKKKSEVEICAFFLYWRRRCSKELNCFDRARRPSNVCDGFLSTRMRNSFDINDQPMYCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1E1</accession>
    <name>A0A068U1E1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039685001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00039685001"/>
    </dbReference>
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    <dbReference type="OMA" id="RFPFNRG"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTP"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
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        <property type="entry name" value="TAF8"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="381" mass="41718" checksum="79BAA18ADC221767" modified="2014-10-01" version="1">MSDGGGENVKEGENNLNHLHSKKSRSRADDFGLSIAKVAVAQICEAAGFQGFQRTALDTLSDVAVRHILEIGKTGNMFANLAGRSQSNVFDIIQGLEDLGSIQGFSGASDVHHCLLGSGTVREMVRYVGEAEEIPFAYSLPGFPVLKEREPGRTFEQTGGSPPAEHIPPWLPVFPDPETYVSLHKIDEKMAQIWEDEVGGPVEKRRELDKTFANLQQRMACNGTQPSVEVDFGNEAKEKGLVECNPFLTPPLQHGEKEVSLVLPPAKLSDEVFLQSANLEVPVSHISAMETFAPGIEAVKSGTFDFEDGRKKVPLNGRPNVRFKLGGGKRCLRVAISSQNQGIDKNSTWFRNDDGMDDKKRRVEQILKPSYESAGTDSLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1U4</accession>
    <name>A0A068U1U4_COFCA</name>
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        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00039611001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1U4"/>
    <dbReference type="STRING" id="49390.A0A068U1U4"/>
    <dbReference type="Gramene" id="CDP02262">
        <property type="protein sequence ID" value="CDP02262"/>
        <property type="gene ID" value="GSCOC_T00039611001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1U4"/>
    <dbReference type="OMA" id="GAIDFQF"/>
    <dbReference type="OrthoDB" id="773121at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1U4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000005">
        <property type="entry name" value="ethylene-responsive transcription factor RAP2-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF197">
        <property type="entry name" value="OS12G0582900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP02262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="430" mass="47378" checksum="A637FDCBC982F469" modified="2014-10-01" version="1">MARKRKAGDCMDNEKNSSSSSSSGDEGNVAWDEMVKEAAAAAAFGGARRARKRFVGVRQRPSGRWVAEIKDTIQKIRVWLGTFDTAEEAARAYDEAACLLRGANTRTNFWPCSSSSSATPALPSKITNLLLSKLKARNNSLAAAAAAASSVPASDHEQQRESHEFPDDQSSDFPDAQFTDFLNDPEDYTPEKDGTTTSTASNLSTNNSSDSHLSSSPEYCLTQHDHHCEVIREPSLDLECWDDTVQSSNGHECLSWDGSTAEDETEEHAEEGNNVNPGIVDFNFVDEIESCYNCSPFEIAGQISQPVEIEDYGDDPSMLSEAMKRMNYERKFSASLYAFNGITECLKLRLRSVSVLQQERSEQLTRLRNACNKNIPDQEQQETLQGDNVELIKKQEEEATPADAGASSSNFDGDLSLWSSIDLPPICYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U231</accession>
    <name>A0A068U231_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039748001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U231"/>
    <dbReference type="FunCoup" id="A0A068U231">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U231"/>
    <dbReference type="Gramene" id="CDP02382">
        <property type="protein sequence ID" value="CDP02382"/>
        <property type="gene ID" value="GSCOC_T00039748001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U231"/>
    <dbReference type="OMA" id="WMQDAAD"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U231"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="193"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="505" mass="56268" checksum="8A56DBF46E1546BB" modified="2014-10-01" version="1">MATRGVACPKLLQNLPYFLLRRFSSAPSPIAAAVSPLNLVERADSEANFSINPTVTPTQSSRDSIVDFQDVKGLFSTLSTPRLLKSLITLEMAAVDPMVDMGLWVMNSRLMETPILKQVISEAVKHTFYDHFCAGKNLEEAGRTITRLWDPAGLQGMLDYGLENAVDYESCDQNTMEFIKTVEYSSSLPPSSVSFVVVKISAICPPSLLRRVSDLLRWEYRDSAFHLPWKLNCFPIFSDSSPFYHTPKKPEPLSPEEERNLLLTHERLFKICEKGMEANVPLLIDAEDTALQPAIDYLTYSSAALYHRDDEPLLFGTIQAYLKDAKDRLVKAKKAADKAGVPVGFKLVRGAYMSSERGIAASLGAESPIQNNIQETHASYNSCAEFLLEEVASGSGAVVLATHNVESGKFAAVKATELGIGKDNRKLQFAQLYAMAETLSFGLKNAGFRVSKYLPFGPVEQIMPYLLRRAEENRGLLSTSNMDRLLMRKELNRRLKSFFTEEQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U235</accession>
    <name>A0A068U235_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039512001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U235"/>
    <dbReference type="FunCoup" id="A0A068U235">
        <property type="interactions" value="2465"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U235"/>
    <dbReference type="Gramene" id="CDP02194">
        <property type="protein sequence ID" value="CDP02194"/>
        <property type="gene ID" value="GSCOC_T00039512001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U235"/>
    <dbReference type="OMA" id="YTDQNKG"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U235"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.20:FF:000014">
        <property type="entry name" value="RNA terminal phosphate cyclase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="185"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41397" checksum="2F1AE02F119FD147" modified="2014-10-01" version="1">MGKISWMKLKGSQNLRLRLLLSTLSSTPILIEDIRADATWPGLRPHEVSFLRLLEKISDDCLVEINETGTKLKYKPGIVMGGKHLIHDCGVIRSIGYFLEPLILLGLFGRKPLCIRLRGITNDSKDPSVDTFRSTTLPILKRFGVNPEGLELKIESRGVAPGGGGEVILSVPILQDSLRAVTWIDEGMVKRIRGVTFSTRVSVQFENTMIHAARGIFNRLLPDVHIFTDHKAGLLAGRSPGYGISLVAETTSGCFISADNSVCYAQGEEEADIEDEAMQDLMPPEDTGEQAAGVLLGEIEQGGVVDSTHQGLLFLLCALCPQDVSKVRVGKLSPYGIEVLRHLRDFLGVKFVIKPDPSTETVILKCVGCGLKNLSRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2F0</accession>
    <name>A0A068U2F0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00040167001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2F0"/>
    <dbReference type="Gramene" id="CDP02700">
        <property type="protein sequence ID" value="CDP02700"/>
        <property type="gene ID" value="GSCOC_T00040167001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2F0"/>
    <dbReference type="OMA" id="CPRLPIM"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP02700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="178" mass="19730" checksum="40E09EBCDB9EED16" modified="2014-10-01" version="1">MKMLVLVNQVLPPIIFLNSSKLTQPSPSTSTDLIILRQSLSEHFSPRLLRTECNSFAEIFPFLSLSYKSKASRSSLLLAVWFTPAKYTSNSFKSMKPSPSVSISSIIRLTSSGDVFEPSMFKMLPKSDDEILPSPLVSNLLNISLTSFTCSLPMLFSFSLVEPLNFSGSAINDFFSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2J2</accession>
    <name>A0A068U2J2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00040163001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the plant CAR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2J2"/>
    <dbReference type="FunCoup" id="A0A068U2J2">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2J2"/>
    <dbReference type="Gramene" id="CDP02696">
        <property type="protein sequence ID" value="CDP02696"/>
        <property type="gene ID" value="GSCOC_T00040163001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2J2"/>
    <dbReference type="OMA" id="KPSRQNC"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2J2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04038">
        <property type="entry name" value="C2_ArfGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044562">
        <property type="entry name" value="CAR1-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45933:SF11">
        <property type="entry name" value="PROTEIN C2-DOMAIN ABA-RELATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45933">
        <property type="entry name" value="PROTEIN C2-DOMAIN ABA-RELATED 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP02696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="166" mass="19025" checksum="DD130B4180470BB1" modified="2014-10-01" version="1">MENLLGLLRIHVIRGVNLAIRDVRSSDPYIIVRMGKQQKLKTRVVKKNVNPEWNEDLTLSIADPSIPIKLQVFDKDTFSFDDKMGDAEFDIGPFIEAVRMRLENIPSGTVITNVKPSRQNCLAEDSNIVWENGKVKQHMFLRLRNVERGEVELRLEWIDIPGSMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U388</accession>
    <name>A0A068U388_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040229001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U388"/>
    <dbReference type="STRING" id="49390.A0A068U388"/>
    <dbReference type="Gramene" id="CDP02747">
        <property type="protein sequence ID" value="CDP02747"/>
        <property type="gene ID" value="GSCOC_T00040229001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U388"/>
    <dbReference type="OMA" id="TLYGNRP"/>
    <dbReference type="OrthoDB" id="1720031at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U388"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd06410">
        <property type="entry name" value="PB1_UP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053198">
        <property type="entry name" value="Gynoecium_Dev_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066">
        <property type="entry name" value="OS05G0427100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31066:SF88">
        <property type="entry name" value="PB1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="543" mass="58887" checksum="07ECB2D6956D89BA" modified="2014-10-01" version="1">MDPPPPPPSSTATDPLPPLPTTPPKLRLMCSYGGHIVPRPQNKSLFYAGGETRIVALDRRTVCTSISALTAHLSRTLFGNRPFHLKYQLPNEDLDSLISVTTDDDLQIMLEEHDRISAVTSPTPSRIRLFLFPIKPESLGSALLDPKADSWFSDALNNTRIVQRGQSVDAAGLGQGLMGLDILGRSDCNAALENPAESMSNNGAEAKEISGAVPESLVLETSSSFGSTSSSISMSNAPAVGIHCEDGSVSLFERRLRVPSSASIESDNSVGSAGIQPKAGIHQEPYVQVASGVSSYSVETENYPPDPQSVIQMQKNVQLAGYQLSQQSEGKHHQYEVQYVQGDMRYMPQYQAGPSPLQSYYPLYQMPMLQQLHSSYAVNQPYPIYLVPVRPNQNYGVSVENTNVASSRPPLHPQAAMIPPVTYKEATTGQPVPESALKFYQTVPQATPAVSAPTTQGKQQFMELPELQHPSQTVVSAPVASSNYASEFDDDVAYTQIYKTQPSASALPLPYQTLMKGVNLMASESSSTQENMGIKHQTPSHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3P6</accession>
    <name>A0A068U3P6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7906 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039523001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3P6"/>
    <dbReference type="FunCoup" id="A0A068U3P6">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3P6"/>
    <dbReference type="Gramene" id="CDP02203">
        <property type="protein sequence ID" value="CDP02203"/>
        <property type="gene ID" value="GSCOC_T00039523001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3P6"/>
    <dbReference type="OMA" id="LDWKLIE"/>
    <dbReference type="OrthoDB" id="18100at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3P6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057228">
        <property type="entry name" value="DUF7906"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25483">
        <property type="entry name" value="DUF7906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654539" description="DUF7906 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7906" evidence="3">
        <location>
            <begin position="80"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="675" mass="75779" checksum="18F7AFC463904943" modified="2014-10-01" version="1">MRRSTTATVLILLLLIYLSTIAASAGILGLDSFLTQQYRRDPQGTNDSFLLLPSSLKRSISHPSVVNPPTPASLLSLQLSVPITVKLVGPTFTSSSPPLLSSFLTSAVSSDHFRVITPFSSDASHHLSLSHSLHLDVSLSSSSLSSHLSEALKTHLSNTPSSIRLPFASVPHSLIDEIIKQDFENEKPIDGIYIYILHLGSQSKSYAYSYTPGDPSPGVTKCMGSIWMGKDRYLWIDLGAGPVDYGPALSGDGVLPRGEFHPLAAMHGRPKSQKAMLADLASLVWSAYQVLFVPSLRIPVPFENSLTVQFIHIYGSSSDNFGLDWKSIERAFTDEINDKGLLLGEQKLSFKKYEVKLSECSICSFAIWRATTSYTSRYLFDNYTLIVSEYLDSRRLHQTISESSEEFRRLAGLPEEDFRSRVLPVYVFDLDASTILLLDRYHQSVAFKDMVIAVRTKNTQTVSDYSCNGRHVFTQTRQLERPLVGSILQSMWGVSPTHLVWSPWHNSTLVDYTWSVGQTPFGPFSDISSLSFVQKDAARRNVLLTSFNYTIGSALDVLESISAHGGEKKLLRQNQQTEFLQRWNLFKYKLDKAISALSHFDYDMALYYLRSSDHDLYAFHSLVYHASQDLEASLTCFKDPPFPWFSVSMAAGVFFTLVYIYAKRETLFQNKRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4A3</accession>
    <name>A0A068U4A3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041871001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4A3"/>
    <dbReference type="FunCoup" id="A0A068U4A3">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4A3"/>
    <dbReference type="Gramene" id="CDP03326">
        <property type="protein sequence ID" value="CDP03326"/>
        <property type="gene ID" value="GSCOC_T00041871001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4A3"/>
    <dbReference type="OMA" id="VVNGMCL"/>
    <dbReference type="OrthoDB" id="1708151at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4A3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF5">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="93"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="722" mass="80834" checksum="B6066D75302282A9" modified="2014-10-01" version="1">MAGGLIASPHTKTTSHLILTSICRTGLLSEYPIHPIRLRFYPLLRLQFTFRPSSRYLYSCTKEQQHGPIDLSKYRETFSKRMALAGLKPHHRLALGVSGGPDSIALCVLAAMWKREGQCGIEVIDSSGFIDGLMAIVVDHGLRRESKEEANLVCSRVTKMGIRCEIALCEWSEGRPKQGHLQEAAREKRYQILQEVCIRHQIGVLMIAHHADDQAELFILRLSRGSGVLGLSGMASVSQLFPMFPDYSREALNWHGLLLVRPLLEFSKEDMFQICKGGNQEWVEDPTNQSPVFARNRIRMSLNNLSSSIFKAELQAIISACREMRLHVDKICSNLINQAVTIMPEGYAVINLKILNASSIKDIYLSKFLALVLQFISQRHRPVRGSASKLLLDYIRTFPSRTCLTAAGCYLSPVPGSKGSKVLICCSLNSNVPVKLEIIQAHANGKQNSISSEVEQIVRNAKACLDKFICGVSDVRLFSLTSPHIVDLKSSESVLIEAKRLGILSNSTYDTIFSLQNHEKQHFMSKTEVMSDRDLTNGRKPEDTIASRRIYPGQIGYFMSRFLIKWNPCREMPYKLFSSSETHYDKVLELERQQSCSSCLVHHEHVAEIRCMVDSDWLYLANLSKSQNMGNSLEQVLSAAAIKQEAGKIKTWSDFVKLSAQRALMSLKCIPVNARRSLPVLVDSQGLLLSIPNVGFRHCPCLDVCAIFKPRVPVGGGHTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4G3</accession>
    <name>A0A068U4G3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041974001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4G3"/>
    <dbReference type="STRING" id="49390.A0A068U4G3"/>
    <dbReference type="Gramene" id="CDP03401">
        <property type="protein sequence ID" value="CDP03401"/>
        <property type="gene ID" value="GSCOC_T00041974001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4G3"/>
    <dbReference type="OMA" id="HRHHPIY"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4G3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045319">
        <property type="entry name" value="KAT/AKT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45743">
        <property type="entry name" value="POTASSIUM CHANNEL AKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45743:SF2">
        <property type="entry name" value="POTASSIUM CHANNEL AKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11834">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51490">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="KHA" evidence="7">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="412" mass="45350" checksum="69DBFBB39FF1A591" modified="2014-10-01" version="1">MNIIQANVGDGTIIMNNLLQHLKELKDPIMEGVLIETENMLARGRMDLPLSLCFATLRGDDLLLHHLLKRGLDPNESDNDGRTALHIAASKGNENCVLLLLDFGADPNSRDSEGNVPLWEAMLGRHELVVKLLSDNGAKITSGDVGQFACTAAEHNNLKLLQEIVRLGGDVKRPRSNGSTALHVAVCEGNNDIVKFLLQQGSDIDKTDEHGWTPRALAEQQGHEDITALFESIKETKTQPVAPILEEKHGVRFLGRFKSEPTIFPVPQEGSFRAVGGSWGRSSRRRRADKFHNSLFGIMSAARNGENSLLLSVNQAKLATVTRIYVARVTISCPEKEDVAGRLVCLPPSFQELREIGFKKYGFWPARILNKDGAEIDEIELVRDGDHLVLVSDGGVREPNQQRAEGADGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U567</accession>
    <name>A0A068U567_COFCA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015230001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U567"/>
    <dbReference type="STRING" id="49390.A0A068U567"/>
    <dbReference type="Gramene" id="CDP03462">
        <property type="protein sequence ID" value="CDP03462"/>
        <property type="gene ID" value="GSCOC_T00015230001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U567"/>
    <dbReference type="OrthoDB" id="10645916at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U567"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040286">
        <property type="entry name" value="At3g25440-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31426">
        <property type="entry name" value="GROUP II INTRON SPLICING FACTOR CRS1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31426:SF2">
        <property type="entry name" value="OS01G0958400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="136" mass="15739" checksum="77AF63B02FE03CF6" modified="2014-10-01" version="1">MSPIDTLSKKRALEKSKYEQSLESVRRFIANAEKELELYYRHVALYGDPNDGNPNSIFDKPRRIEWARKVEVKEDASSMTEEYSHTLFQTEIDSMDDEILESEEISEFDDKHKNNAASASEIDYEDDGTHIGEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5S5</accession>
    <name>A0A068U5S5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S acidic ribosomal protein P1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00041412001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5S5"/>
    <dbReference type="FunCoup" id="A0A068U5S5">
        <property type="interactions" value="1180"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5S5"/>
    <dbReference type="Gramene" id="CDP02968">
        <property type="protein sequence ID" value="CDP02968"/>
        <property type="gene ID" value="GSCOC_T00041412001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5S5"/>
    <dbReference type="OMA" id="YSAHDHE"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5S5"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L12_arch"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11415" checksum="0D970B2A3483E51E" modified="2014-10-01" version="1">MSVSELACTYACLALHDDGIPVTAEKIATLVKAANVTVESYWPSLFAKLCEKRNIEDLIVNVGCGGGAAVAVAAPGAGAGSAPAAAAAPAAEEKKEEPKEESDEDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5X8</accession>
    <name>A0A068U5X8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00016109001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5X8"/>
    <dbReference type="Gramene" id="CDP03672">
        <property type="protein sequence ID" value="CDP03672"/>
        <property type="gene ID" value="GSCOC_T00016109001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5X8"/>
    <dbReference type="OMA" id="YGESSTC"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5X8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="370" mass="39888" checksum="AD559EAA52B54381" modified="2014-10-01" version="1">MAYDEGGSPALFRSQECPLREWTPSNGVSQNHPTANCGFAAAILQGRRNYQEDRIACNPAMKIPFLGNDGQKNVSVGVAAVFDGHGGAEASEFASKKFLSYFYLNVLFNIYKQASPHKGNDEANQNKSSVESRSGTTSSLIDDTSLYDILNEALIRTFRDIDSEFTREALRNNYASGSTGTVALIVNGRLLVGFVGDSKALLCSNRSLASQGGEGTSMRTSYVQELTKDHHPDREDEKARIETAGGFVHTWGVPRVNGILAMTRAIGDLSLRRFGVIAEPEVIAWQTLTTDNSFLVIGSDGIFEGLTPANVCAILHNNACKPGTTESSGSSSCLAPSALAKRIVNNAYENGSHDNISVIVIHLESAYHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6B4</accession>
    <name>A0A068U6B4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016343001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6B4"/>
    <dbReference type="Gramene" id="CDP03847">
        <property type="protein sequence ID" value="CDP03847"/>
        <property type="gene ID" value="GSCOC_T00016343001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6B4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="8765" checksum="F745DB4BCDE748B4" modified="2014-10-01" version="1">MLKSNRCSNLKFPSDPTSESMSYDLNLRNSGDGVGANPQEFPNSASNEDPVLHKLREDFGVIVLKKSLETKQRAVVVTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6G6</accession>
    <name>A0A068U6G6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00017397001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6G6"/>
    <dbReference type="FunCoup" id="A0A068U6G6">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6G6"/>
    <dbReference type="Gramene" id="CDP04101">
        <property type="protein sequence ID" value="CDP04101"/>
        <property type="gene ID" value="GSCOC_T00017397001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6G6"/>
    <dbReference type="OMA" id="PKKGNCC"/>
    <dbReference type="OrthoDB" id="6078042at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6G6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47820">
        <property type="entry name" value="BNAC05G24000D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47820:SF3">
        <property type="entry name" value="OS07G0499800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="846"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="899"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP04101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116566" checksum="DA6D3D357F642F25" modified="2014-10-01" version="1">MASSQVEIASSSPFGYVLKDRNRHDHRYRTRESNAFQKNFKDLVQTHLNSCGPGHSRNSGSVSNGKLNSNENSPRHHIDFTDLWVHNPQRNNNENNPKESRAGEKWDKARDMVFAFERKSQENTSSGGPNSPVKSESSVEAQSLGGVSSLVRMWRDFEAEARCFSATNSPVCSSRSNSVMFFNDNSSYADAPLRGPDAGEEFADLRPATPSKSEDLFLDWESDQTGLSGPPSSRGRDSDATESERIRVADIIKKLSSKGEDHNDTISQHSLPRVRTSLEKAEQRVFSPVSSSPRIRGRQAFTDLLMHLERDRHRELERLVDKKAVSRFSHRGRIQAMLRVRFLRRGAEGKDGRQSNSASFDSKRLAPSAIVNIRMIKWIHGFPLTKRNLKYKTLSSLLRNPNEYQITLWCYANFLFLSTSSCIVIPLFSQSIPARMKLRIQFLFKPQFMMWTTLHSIKRYVGKDLLYIRKGNALMWILVIFCSSHFRLNYPSWHAMERFMAQVRHSGTDSRSQQGEAVDKITEGEKSPMIYQQRKENHQQELTEPTKSPKAVVDNDVDAQEPIRENQIVGTNYHGSNTTVRQNAVQVQRSEILHQEAISSPGVMQQRTSSGSENDGKTEVTSTANSMKMDEANENSEIEESSNQNLIASTNGFMDDAYKAQGDWKEDEGTHQDLVVSDYGQETDVFQPFEWEELQDDYEQEVDMNQDWISDVSRPRSTWEDLRQARYQEMLDPFMQNDEIRQLLNRKSVSNFLSSGLREGIDRLMMSRTQSQPNEQANQRQEEHNSYQVEEVTKKVEMQEVQKEPEERVEEEEEIADHSNDLGEDESDEIQTGREYTESQDYFGQTTSWDYNQDNEVGDNYFDPTEFESPEQPLSPSSPPETQPSSSFTNHPSIEMEFIYELRGNMEQLHQEISELRRSVKSCIDMQVKLQESFTRDVTTASCHSGTGRKKRKDSSQSKKSGRGRCYICYEMQIDSLLYRCGHMCTCFKCASDLQWGSGKCPICQAPIIDVVRAYACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6P0</accession>
    <name>A0A068U6P0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00041801001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068U6P0"/>
    <dbReference type="Gramene" id="CDP03273">
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        <property type="gene ID" value="GSCOC_T00041801001"/>
    </dbReference>
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    <dbReference type="OMA" id="NRIEEWN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
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        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Protein phosphatase 1 regulatory inhibitor subunit PPP1R7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein phosphatases pp1 regulatory subunit, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP03273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36317" checksum="32DA8DD4D84309B9" modified="2014-10-01" version="1">MDSPMGDGGENPTVLDLTSYQLRDLDSVDLPPSLTELDLTANRLSKLDPRIAQLSNLKKLSLRQNLFDDSGVEPLATSHLIADLEELVLRDNQLKKVPDVSIFKKLLVFDVSFNEIPTLQGLSKVSTTLRELYVSKNEVTKMEEIDHFHALQILELGSNNLRVMENLQNLINLQELWLGRNRFKTVNLCGLKCIKKISLQSNRLTSMTGFEECVALEELYLSHNGISKMEGLSTLANLRVLDVSSNKLTEISDIKKLTQLEDLWLNDNNITSLDGIAEAVAGSRDALTTIYLERNPCVNSPNYIVTLKEIFRNIQQIDSELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8W5</accession>
    <name>A0A068U8W5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00019906001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8W5"/>
    <dbReference type="FunCoup" id="A0A068U8W5">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8W5"/>
    <dbReference type="Gramene" id="CDP05005">
        <property type="protein sequence ID" value="CDP05005"/>
        <property type="gene ID" value="GSCOC_T00019906001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8W5"/>
    <dbReference type="OMA" id="SLMGDWI"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8W5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001864">
        <property type="entry name" value="Calcium-dependent protein kinase SK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000085">
        <property type="entry name" value="CDPK-related kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000101">
        <property type="entry name" value="CDPK-related kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001294">
        <property type="entry name" value="CDPK-related kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="160"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="613" mass="67945" checksum="F141C219DA22CCD4" modified="2014-10-01" version="1">MGHCCTKSVSASVHKVDDPIASFDGDPSATATSAGDSAAADNRRKPRPAVSPGPPSANGHSNKSTPAHSFAASPWQSPYPAGVRPSPSPARTPGRKFRWPFPPPSPAKPIMSAILKRQGAPAKPNEGPIPEHDGGGAADNEGERPLDKSFGYPKNFGAKYELGKEVGRGHFGHTCWAKGKKGELKNQAVAVKIIAKAKMTTAISIEDVRREVKILKALSGHKNLVQFHEAFEDAQNVYIVMELCEGGELLDRILSRGGRYTERDAKSIIVQILSIVAFCHLQGVVHRDLKPENFLFSTRDEDASLKIIDFGLSDFIRPDQRLNDIVGSAYYVAPEVLHRSYSVEGDIWSVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWPTVSAEAKDFVKRLLNKDHRKRMTAAQALTHPWLRDQDCAVTLDILIYKLVKSYVRATPLKRAALKALSKALTEDELTYLRAQFKLLEPQDGFVSLQNFRTALMKNASDAMIESRVPEILNLLEPLSHKSLEFEEFCAAAISVYQLEALEKWEHIASTAFEKFELEGNRVTSVEEIAKEMNVGPAAHSLLKDWIRESDGKLSFLGYTKFLHGVTLRNSNLRHHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9H3</accession>
    <name>A0A068U9H3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00020105001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9H3"/>
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        <property type="interactions" value="787"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9H3"/>
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        <property type="protein sequence ID" value="CDP05156"/>
        <property type="gene ID" value="GSCOC_T00020105001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9H3"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:proline-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
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    </dbReference>
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        <property type="entry name" value="C-terminal domain of ProRS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF3">
        <property type="entry name" value="PROLINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP05156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="448" mass="50593" checksum="F108365BCA1D5EAB" modified="2014-10-01" version="1">MVIRPYGYAIWEAIQEYLNVKFKETGHSNMYFPQFIPYSFIEKEASHVEGFSPELALVTIGGGKELEEKLVVRPTSETIVNHMFTQWIHSYRDLPLMINQWANVTRWEMRTKPFIRTLEFLWQEGHTAHTTLEEAEKEALQMIDVYTKFAYEQAAIPVIAGRKSRVETFAGANRTYTIEAMMGDRKALQAGTSHNLGQNFSQAFGTQFTDENGQRQHVWQTSWAISTRFVGGIIMTHGDDTGLMLPPKLAPVQVVIVPIWKKADERTGVFNATSSVKDTLQAAGIKVKVDDSDQRTPGWKYNFWEMKGVPLRIEIGPRDVSSGTVVISRRDIPGKQGKVFGISMDCSILVAYVKGLLDEIQSCLLERATSFRDCNIVDVSSYDELKEAISEGKWARGPWSARDEDELKIKEETGATIRCFPFEQPQGTKSCLMTGSPAEEVAIFAKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAX2</accession>
    <name>A0A068UAX2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00018878001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAX2"/>
    <dbReference type="STRING" id="49390.A0A068UAX2"/>
    <dbReference type="Gramene" id="CDP04778">
        <property type="protein sequence ID" value="CDP04778"/>
        <property type="gene ID" value="GSCOC_T00018878001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAX2"/>
    <dbReference type="OrthoDB" id="5857966at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAX2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000537">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF7">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="132"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP04778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="402" mass="45167" checksum="9B6238296C7B910F" modified="2014-10-01" version="1">MTPIPNTLWENASYDTFKTSIRQECEQACLNDCNLLTNPKVALVKVGMPGSPVGGGSSYPQLHPKKKLRLDILIISISLLVFAPVILVISGVLIHIHQLGAHKNMSRYKNAEPMGDVAPRAFTYAELERATNDFKEELGQGAFGTVYKGMLMDFQKAVAVKRLEKVLAEGEAEREFHNEMAVIGKTHHRNLVRLLGYCADGPKKLLVYEYMSSGSLADVLYAKENQPNWDEGIKIACDIARGILYLHEECETQIIHCDIKPQNILMDEHRCAKISDFGLAKLLKHDQTKTFTAIRGTKGYVAPEWHKKLPVTVKADVYSYGIVLLEIICRRKNIDWSFPEDQAILEEYAYDCFEAQEMIKIAIWCIQGEPSLRPSMKKVLLMLEGTVDIPIPPNPTSFLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBM1</accession>
    <name>A0A068UBM1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00020710001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBM1"/>
    <dbReference type="Gramene" id="CDP05584">
        <property type="protein sequence ID" value="CDP05584"/>
        <property type="gene ID" value="GSCOC_T00020710001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBM1"/>
    <dbReference type="PhylomeDB" id="A0A068UBM1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000317">
        <property type="entry name" value="Inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000453">
        <property type="entry name" value="Leucine-rich receptor-like protein kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001347">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654755" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="15">
        <location>
            <begin position="29"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="16">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP05584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128078" checksum="9FA8177E5AEFCD42" modified="2014-10-01" version="1">MEHHLLCTFSSLLLLFLFLFSSIPVTSQFPFGSNKQAHNYSNVSCVENERQALLQFKHGLIDESNRLSSWIGEECCSWEGISCHKTTGSVLKLDLRNTADDNDYYTNWLGGQLSPSLVNLTNLQYLDLSLNIFSGIQVPAFFGLLKNLRYLNLSSAGFDGEIPHHLGNLSHLRYLDLAWNSLSIKDLGWVAGLSSLEGLVLSKLNLTAAQDGLQSINMLPSLTTLDLNACELFIHPHLSHVNFTSLAFLDLSENNFNNYMVPPWLRNLTGLHDLRLVHLDLFYNRFDVSMLKSLCNISSLTYLDLSFNNLQGSIPSEIGQLINLTYLDLSNNNLQGSIPSEIGQLPKLTNLLLYLNSLNGTIPTSLGQLTKLQAFDIGYNSLAGVLSEDHFANLRELKSLNLTGNSLALNVSSLWVPPFQLQEIQMGSIIVGPRFPAWLRTQKELEVLGMRDASISGAIPNWFRVLCDDIRILDLSSNSLTGNPLEFKSLPLDISVLDLSHNFLTGHIPQLQHALAFLALNDNRFTGTIPEDLCKSENLSELNLSNNLLSGRVPLCLGNLRYLSFLNLANNSLSGQIPSSLGNLRRLSYLHLNGNKFVGKLPASMQRLSNLEALDLGDNGLKDIIPAWIGESLSILRFLRFQSNNFHGPISDTLCQLSLLRLVQLQVLNLSQNHLTGRIPDKIGNLKQIETLDLSMNALFGAIPESLSDLYSLNSLNFLTYLDLSGNNLQGSIPHEIGQLPKLTDLLLSDNSLNGTIPTNLWQLTKLQAFDVDYNSLTGCEYLSELNLSNNLLSGRVPLCLGNLRALLFLNLANNSLSGQIPSSLGNLRRLSTLHLNGNKFVGKLPTSMQHLKNLQMLDLGDNGLKDIMPAWIGESLSNLRFLRFQSNNFHGPIADTLCQLSLLQVLNLAHNNLSGFIPHCFNNITALMVSGLYGDYGIEAQASLQDIKGGRESEYLQGSLPLVKSISLSANNLVGEIPDGVMELVQLQVLNLSQNHLTGRIPDKIGNLKQLETLDLSMNALFGAIPKSLSDLYSLNSLNLSHNKLSGPIPSGNQLQTLTDPSIYEGNSGLCGKPLPNNCWEHKSPTKNGPIDDDEGHGESDWSWFYAGIGPGFAVGLLGVLGILLFKKSWRYAYFKFIESVCDKIWVKSTRPRRNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBS8</accession>
    <name>A0A068UBS8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00020038001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBS8"/>
    <dbReference type="STRING" id="49390.A0A068UBS8"/>
    <dbReference type="Gramene" id="CDP05103">
        <property type="protein sequence ID" value="CDP05103"/>
        <property type="gene ID" value="GSCOC_T00020038001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBS8"/>
    <dbReference type="OMA" id="PPIICHY"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBS8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF106">
        <property type="entry name" value="POTASSIUM TRANSPORTER 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="63"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP05103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25765" checksum="C2E23C9C750310FF" modified="2014-10-01" version="1">MTSMLNKIPQGGWVPFAISAILGTVMLSWTYGRSKKSMYEGGGKMSIGELNQKLSSTCIFRTPGICFFFTDLVDGIPPIIRHYIQHTNSVREIMVVVTIRTLPIKTVLPEERFVVGRLGVEGVYRCLVQLGYKDSLNMEGGDYAREIVAKLRGNADTTAEQRKLHSASENETVFVMGRTVLAANENDGWLARFTIEYLYRFLQKNCRSSVSALHLPPEKTMQVGMLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC34</accession>
    <name>A0A068UC34_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00020995001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC34"/>
    <dbReference type="FunCoup" id="A0A068UC34">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC34"/>
    <dbReference type="Gramene" id="CDP05729">
        <property type="protein sequence ID" value="CDP05729"/>
        <property type="gene ID" value="GSCOC_T00020995001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC34"/>
    <dbReference type="OMA" id="HMNGRIA"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC34"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF106">
        <property type="entry name" value="ANTHER-SPECIFIC PROLINE-RICH PROTEIN APG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657516" evidence="4">
        <location>
            <begin position="37"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="371" mass="40254" checksum="C048919433A7DD22" modified="2014-10-01" version="1">MACLRSSSTVATSSGFFAFRNMSLFFFFALISFSEGQTVPAVYVFGDSLVDVGNNNYIKDSLLKANYPYNGIDYPGGKPTGRFCNGKNAADFIAEKVGLPTSPPYLSDTSDVFLEGVSFASGGSGLFNTTGQGFLRKTLSLAQQVDYFTALHDRLVKQLGPAAAQQRLSKSLFLVVIGSNDAFAYFESLNNRKVMKVTPDQYVDQMISILQGLLKQIHSLGARKFVVVGLGSLGCCPGQRHDTGNEQCNQDINALAIKYNQGLASMLAGLKSVLNDFSYSLFDTYTVLLDIIDNAATYGFTEAKAACCGLGKLNADVFCTPLAVYCPNRTDHVFWDKVHPTQATDKIMVDTIYSGSQPYVSPINVKQLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD70</accession>
    <name>A0A068UD70_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00023296001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD70"/>
    <dbReference type="FunCoup" id="A0A068UD70">
        <property type="interactions" value="1144"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD70"/>
    <dbReference type="Gramene" id="CDP06441">
        <property type="protein sequence ID" value="CDP06441"/>
        <property type="gene ID" value="GSCOC_T00023296001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD70"/>
    <dbReference type="OMA" id="FWDFAKQ"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045037">
        <property type="term" value="P:protein import into chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GYF_2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37755:SF1">
        <property type="entry name" value="PROTEIN TIC 56, CHLOROPLASTIC"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="508" mass="59424" checksum="96D017E3CB42B574" modified="2014-10-01" version="1">MASLNFNFNPFNDDNWFKKPINLVSLFENLNPFKPQASTPNFAALSFKPSPKKPKNEAANPGKYEQMLDQFYWECENLPDYRHTPEVERLLNEDPVFEKLENPTPEELAENAKRWEEFRASPVVQFLARAEEIANKINELELKENSTPYRKEDRKLWKAVPNVLGLDGRPMPRKAIKTKRESDDKFWDFARQFFFGLWRFRQRPYPPGRPIDVAQAIGYKRLERRYYDFIMRSSGWYYKDRLGRTRGPMELIQLKTAWGAGIIDKHTFIWGDDMDEWAPIGMVYGLERAIATWEVRFGAAATAALHKLQKGMPPWAPLKGHEQKTYKQLQEEAYESKRRDLAVLEANEGVWPGVRIPSHALFLWASGSELTSVLEADHMPNKFIPKDLRYQLAKVIPGLRPWEVLSVEQAMDQITYGGEWYREPLGSYTTGPPYIQEWNKDVRTLFDIFHNLSVQVYNKLERTIPGFSTVMERVQAESIESEEKRREKREAEKRAEKEKSFGRVEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDJ8</accession>
    <name>A0A068UDJ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022986001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDJ8"/>
    <dbReference type="STRING" id="49390.A0A068UDJ8"/>
    <dbReference type="Gramene" id="CDP06259">
        <property type="protein sequence ID" value="CDP06259"/>
        <property type="gene ID" value="GSCOC_T00022986001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDJ8"/>
    <dbReference type="OMA" id="GQQKWSG"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDJ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="139" mass="13255" checksum="21AF3BE736031317" modified="2014-10-01" version="1">MSAIALLQKAAQIGATATNVSLLRGFGIVSSASASSGQQKWSGRAIESDSVSLAAGLGLGLPCDSGSSLKELMLGTPSVFGPKHTTLDLLGLGMAAGGGPSGGFSALMTSIGGGLDDAAAAASFGGSGEYSGKDMGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDL0</accession>
    <name>A0A068UDL0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00020882001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739102">
        <property type="protein sequence ID" value="CDP05683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDL0"/>
    <dbReference type="STRING" id="49390.A0A068UDL0"/>
    <dbReference type="Gramene" id="CDP05683">
        <property type="protein sequence ID" value="CDP05683"/>
        <property type="gene ID" value="GSCOC_T00020882001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDL0"/>
    <dbReference type="OMA" id="EECELFH"/>
    <dbReference type="PhylomeDB" id="A0A068UDL0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.990">
        <property type="entry name" value="Glycosyltransferase family 88, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF255">
        <property type="entry name" value="CYTOCHROME P450 72A11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP05683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="192" mass="21826" checksum="443F69AB2C650A61" modified="2014-10-01" version="1">MRQIKKEVNDSIRRIINSKLKAMKAGESCDDDFLDRLLESNSQEIHEHGSKDVGMTAQKEIEECELFHFAGQAVTTFELIFSSKILLGNPPAPQPNPPHTKERILALFWRKSSQGGLNFFLLCTCSYDYITGNYAIICNAKAISTVTLLFAGILILKLLALIYHDPELWGDNVKEFKPKRFPELSHFILQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE47</accession>
    <name>A0A068UE47_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00023438001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE47"/>
    <dbReference type="STRING" id="49390.A0A068UE47"/>
    <dbReference type="Gramene" id="CDP06547">
        <property type="protein sequence ID" value="CDP06547"/>
        <property type="gene ID" value="GSCOC_T00023438001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE47"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF94">
        <property type="entry name" value="COPPER TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="3 6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP06547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="186" mass="20338" checksum="EF33B87F5E45F2DD" modified="2014-10-01" version="1">MQHLSSNFLNPRMPQSHTRTPSPHPSPGSSYHHIFFMAIDALPIHHNTTAPPPPPPPPTNVHHHHPFSLFTHFYWGKDAEILFSGWPGHNSAMYALALLFVFFSAVLVELFSNINVVRPGSKRVAAILFQMGIRAIRAGFAYLVMLSVISYNGGIFIAAVVGHAVGYVAFGSPVSIFRKGSANTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEP7</accession>
    <name>A0A068UEP7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00024141001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable carboxypeptidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="11"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEP7"/>
    <dbReference type="Gramene" id="CDP07045">
        <property type="protein sequence ID" value="CDP07045"/>
        <property type="gene ID" value="GSCOC_T00024141001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEP7"/>
    <dbReference type="OMA" id="EHGPCNV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000060">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103963" description="Carboxypeptidase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="494" mass="54730" checksum="E68FFA56096AE031" modified="2014-10-01" version="1">MANALLPLLLLCILLLGPATFSARIGNHQKALPHLVPKFRVSPAKGLIRGLNLHPRQDVNIVANDFAAANDSRIVEKPLKLNILGAPDPSVADLGHHAGYFNLPHTVGARMFYFFFESRRKNNSDPVVIWLTGGPGCSSELALFYENGPFHITDGLSLVWNNFGWDKISNIIFVDQPTGTGFSYSSSNDDIRHDEKGVSNDLYDFLQAFFRKHPEYAKNEFYITGESYAGHYVPALAGRVNQGNKNKEGILVNLKGFAIGNGLTNPLIQYKGLPDYALEHKLISQSYYNGMQESVTECEEAIEACGTSGTDSCETAYELGNEIFDDILSSAGNINYYDIRKQCEGQLCYDFSNVENFLNQDTVREALGVGHIEWVSCSSTVYDAMVDDWMRNIEVDVPALLEDGIKLLVYAGEYDLVCNWLGNSRWVQAMEWSGQKAYLAAPNTSFTTNGVEAGVRKGYGSLTFLKVLNAGHMVPMDQPQAALEMLESWIKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH30</accession>
    <name>A0A068UH30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00024013001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UH30">
        <property type="interactions" value="2048"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UH30"/>
    <dbReference type="Gramene" id="CDP06953">
        <property type="protein sequence ID" value="CDP06953"/>
        <property type="gene ID" value="GSCOC_T00024013001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH30"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000012">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="18">
        <location>
            <begin position="1609"/>
            <end position="1994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP06953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2321" mass="267782" checksum="5FA284F6CE916161" modified="2014-10-01" version="1">MNGSDNRRRDRRDTRISKKQKLILNAEEQLESKLGFDLFTEGDKRLGWLLTFASSSWEDQGTRKVYSCVDLYFVCQDGSTFKAKYRYRPYFYAATKPKMEMDVEAYLRRRYEGQIADIEIIEKEDLDLKNHLSGLCKSYLKIAFDTVQQLMSVKNDLMHIVERNQEKLDASEAYEFILTEKSKQRPQDFIDCITDLREYDVPYHVRFAIDNDVKSGQWYDVTVSSSGIELQRRTDLLQRAEVHVCAFDIETTKLPLKFPDAEYDSIMMISYMVDGQGYLIINRECVGEDIEDLEYTPKPEFEGYFKVSNVKNEEWLLREWFAHMKEVKPGIYVTYNGDFFDWPFLESRAAHHGFRMNDELGFQCDKNQGECRAKFACHLDCFAWVKRDSYLPQGSHGLKAVTKAKLGYDPLEVNPEDMVRFAKERPQMMASYSVSDAVATYYLYMTYVHPFIFSLATIIPMPPDEVLRKGSGTLCEMLLMVEVGELTYATLAYKANVICPNKHQSDPEKFYNNQLLESETYIGGHVECLESGVFRSDLPTSFKLDPSAYEVVFLIVSVSYLCAYFYDRKDAMCLLFHEQINFSILSVRHVKILPNPLHYLFNHKFPALHHYLSIMYLVYFYEYVSVILKGHDNFSRIYNKQERWLGSIRLVEGKMDLESISNYYEVKDAISEKLIRLRDDPVHEECPLIYHLDVAAMYPNIILTNRLQPPSIVTDEICTACDFNRRGKNCLRKLEWVWRGETYMAKRSDYHHLKRQLESELVEGADGQSAKTFLELPKAEQQSKLKDRLRKYCQKAYKRVLDKPVTELREAGICMRENSFYVDTVRSFRDRRYEYKGLNKVWKGKLTEAKASGNPMRIQEAQDMVVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGAVTYTGAKIIQNARLLIERIGRPLELDTDGIWCALPGSFPENFTFKTKDPKKKLTISYPCVMLNVDVARNNTNDQYQIELTVNSNYVQTLKDPITRTYTTHSECSIEFEVDGPYKAMILPASKEEGILIKKRYAVFNDDGTLAELKGFEIKRRGELKLIKVFQAELFDKFLHGCTLEECYSAVASVANRWLDLLDSQGKDIADSELLDYISESSTMSKSLADYGEQKSCAVTTAKRLADFLGDTMVKDKGLRCQYIVACEPKGTPVSERAVPVAIFETEPEIMKFYVRKWCKISSDGGIRSIIDWSYYKQRLSSAIQKTITIPAAMQKVANPVPRVIHPDWLHKKVREKDDKYRQKKLVDIFGSLSKNNCLKGSSDVISNKHGVDEQNAADLEDFGKISRTFPVGPRPVVHCFDANKVQQLSKTSSELDCPPQQTALSKESIDRNVDYRGWLELKKRKWRETREKRKCQRLDAARKSNKQNGTDVLPGFMFKYGKAKSRVGVNSYFENHQMALTRSHWQIIQLVPSPQHGHFFAWVVIEGVMRKIPITVPRVFFLNSKAPVTEEFPGRRVNKVLPHGHTSYNLIEVIIEEEQFKEESKKLAAHLADPEVEGIYETNVPLEFNAILQLGCVCKVDKKAKRRNGQDSWSMSELHMKTTTECSYLEQSLSFFYLYHSISEARAIYVGYFPASRLISVLVVNPFQNKELSPQILERLFREACQALSFQQPNSAERMSFKVEYVGHVKDAEKNMQRMINDYRDRHHGPVIAVIECPNSDLLKSNIQALDDFPCVNIPSNARDSQYQALGWQIVAAKIGMHRCAASSQWLNERITLSRYAHVPLGNLEVDWLLHTADIFFSRALRDQQQVLWISDNGIPDLGGVNEEMSSFIDEVNQPILNYPGAYRKVSVELKIHHLAVNALLKSNQINEIEGGTLFGLDQDLNPATKFPDEQYCFDEVTSCAPAFRVLKQLIQRCLADAVTSGNVFADAMLQRLYRWLCSPKSKLHDPAIYRMLHKVMQKVFALLVAEFRKLGATIVFASFSKVIIDTGKSDLLAAKAYCDSLLKTLQTRDLFEWIEFEPLQFWHSFLFMDQYNYGGIQASFQDESSNDKARPSDVTIQKESEVEIVSSWNIAENLPKLTQDHFILIVSEFMYMPWKFAQEQAAKRACLADGDLCTPSITAAAAETFDLQMTEDLKNKIRSYFTDKLLKIVCDPSLLMKRKSRDQQNIMNTNTQPLESCHQGDPALEFIKYVSTVLALDQSVQHEVLIMRKNLLKFVRVREFAPEAEFYNQSPSFTLPNVICSYCNECRDLDLCRDRALLGQEWRCAVPQCGQPYDRELMENALLQIVRQRERLYHLQDLVCLKCNQIKAAHLAEHCSCAGSFRCKEDVSEFRNKMQVFLNIAQDQKFQLLQECTSWILEVSQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI11</accession>
    <name>A0A068UI11_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00026917001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI11"/>
    <dbReference type="FunCoup" id="A0A068UI11">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UI11"/>
    <dbReference type="Gramene" id="CDP08170">
        <property type="protein sequence ID" value="CDP08170"/>
        <property type="gene ID" value="GSCOC_T00026917001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI11"/>
    <dbReference type="OMA" id="EMHQQTP"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI11"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000018">
        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016679">
        <property type="entry name" value="TF_GATA_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016992">
        <property type="entry name" value="TF_GATA_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP08170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="360" mass="39899" checksum="70F286126CFF8E0F" modified="2014-10-01" version="1">METPEFFQGGYYNTHMAPEKRLSDAKNSDHFIIDDLLDYPNDDGMVADGTFDTTITAGTSTDSSTVVDTSCNSSFSGSTEPHLPGGDMGCRNFTDGQFSSELCVPYDDLAELEWLSNFVEESFSSEDLQKLQIISGMKARTNEVSETHDDQPEPNRETATPMLRPEMSVPAKARSKRSRAAPCNWTSRLLMVTPSTTTLTAATTTTIMAAAMSSSSDSEITPSTGKKAVKAPSKKKEVYDQNASMANGEGRKCLHCATDKTPQWRTGPMGPKTLCNACGVRYKSGRLVPEYRPAASPTFVLTKHSNSHRKVLELRRQKEMLRAQQQQHQFLHQNMMFDVSSNGDDYLIHQHIGPDFRQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJN0</accession>
    <name>A0A068UJN0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00027444001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJN0"/>
    <dbReference type="FunCoup" id="A0A068UJN0">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP08512">
        <property type="protein sequence ID" value="CDP08512"/>
        <property type="gene ID" value="GSCOC_T00027444001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJN0"/>
    <dbReference type="OMA" id="DHQKKDD"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJN0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="252"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="376" mass="42364" checksum="71C74DC90A82DBE9" modified="2014-10-01" version="1">MATENTSTKKRKQRYLPHNKPVKKGAYPLHPGVQGFFITCDGGRERQASHEAINVIDSFFEEYVHGAGSNKQQEAIPKQLMNKKTKFVYSDSSEDEDGDDDGIGNNIHRSTEEKDLRTDNITNANCETLVDEKLGSQNEDDSSVQEEIQEDKDGKEEVTKKHKFQEGDAGEQPIKKQCVEISSSKSPNLASSKMEEKSVDKLIEAELAELGDKSKRRFSNLDSGCNGVVFVQMRKRDDDPNPKDIVQYMMTSLASTRKHMSRFMLRVLPIELSCYASEEEIVRAIKPFIAKYFPVEAQKPHKFAVLYEARANTGIDRTKIIDAVAKSVPSPHKVDLSHPDIHIVVQIVKTVCLIGLVEKYKELAKFNVRQLTSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJR6</accession>
    <name>A0A068UJR6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cAMP-regulated phosphoprotein 19-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00027856001</name>
        <name evidence="5" type="ORF">GSCOC_T00029042001</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DH200</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DH200</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJR6"/>
    <dbReference type="FunCoup" id="A0A068UJR6">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJR6"/>
    <dbReference type="Gramene" id="CDP08765">
        <property type="protein sequence ID" value="CDP08765"/>
        <property type="gene ID" value="GSCOC_T00027856001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09604">
        <property type="protein sequence ID" value="CDP09604"/>
        <property type="gene ID" value="GSCOC_T00029042001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJR6"/>
    <dbReference type="OMA" id="QIDENAM"/>
    <dbReference type="OrthoDB" id="1902088at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF28">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 19-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12400" checksum="5C5D4043F28F0683" modified="2014-10-01" version="1">MSGMEEVKNQAVGDTEKSLPSSQQEEEVIKKKYGGIVPKKPPLISKDHERAYFDSADWALGKQGVEKPKGPLEALRPKLQPTQQQTRYRKSPCAPSEGEDGANASTEDATTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK09</accession>
    <name>A0A068UK09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027642001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK09"/>
    <dbReference type="FunCoup" id="A0A068UK09">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UK09"/>
    <dbReference type="Gramene" id="CDP08622">
        <property type="protein sequence ID" value="CDP08622"/>
        <property type="gene ID" value="GSCOC_T00027642001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK09"/>
    <dbReference type="OMA" id="PMMVDNE"/>
    <dbReference type="OrthoDB" id="1891465at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UK09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF221">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 43-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="384" mass="43689" checksum="FA311E379E053A0B" modified="2014-10-01" version="1">MRISVNGQSQVPPGFRFHPTEEELLQYYLRKKVAYEKIDLDVIRDVDLNKLEPWDIQGSTPQNDWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKVIYSNSRRIGMRKTLVFYKGRAPHGQKSDWIMHEYRLDDNSTSNNAAEVENVCNAAGEAAAQEEGWVVCRIFKKKNHHIIKSLDHATPFVTTCSIVTTAECTRGPRQRLIGSSDDDDDERSMEKILEYMGRTWAEERGRDQANQSATPMFPMMPVDIVTKSTGQLCDRFMKLPGLESPKSSPRTTTACTHACYQPITSLHVLPGRVNTTSTNYRPSETAAGLSDWAALDRLVATHLNGQNETAKHFCNNNNNNRRDYHHDECELWSFVRSSLAPADPPFSHMPNVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK35</accession>
    <name>A0A068UK35_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027928001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK35"/>
    <dbReference type="FunCoup" id="A0A068UK35">
        <property type="interactions" value="2224"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UK35"/>
    <dbReference type="Gramene" id="CDP08821">
        <property type="protein sequence ID" value="CDP08821"/>
        <property type="gene ID" value="GSCOC_T00027928001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK35"/>
    <dbReference type="OMA" id="GMHIRIM"/>
    <dbReference type="OrthoDB" id="25649at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UK35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="110" mass="12393" checksum="28F04AE5934C72FF" modified="2014-10-01" version="1">MAPKQPNTGLFVGLNRGHVVTKKELAPRPSDRKGKTSKRVHFVRSLIREVAGLAPYEKRITELLKVGKDKRALKVAKRKLGTHKRAKKKREEMSNVVRKMRAAGGGEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKK1</accession>
    <name>A0A068UKK1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00026870001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKK1"/>
    <dbReference type="Gramene" id="CDP08133">
        <property type="protein sequence ID" value="CDP08133"/>
        <property type="gene ID" value="GSCOC_T00026870001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKK1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="30" mass="3170" checksum="36CED0C87DBBD03F" modified="2014-10-01" version="1">MEKPINIFINCPSGTMTLGFTNSNNIAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL01</accession>
    <name>A0A068UL01_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00027057001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL01"/>
    <dbReference type="FunCoup" id="A0A068UL01">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL01"/>
    <dbReference type="Gramene" id="CDP08278">
        <property type="protein sequence ID" value="CDP08278"/>
        <property type="gene ID" value="GSCOC_T00027057001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL01"/>
    <dbReference type="OMA" id="SCPTRIM"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL01"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048653">
        <property type="term" value="P:anther development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF31">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="238" mass="26692" checksum="43F40A38D5BAF463" modified="2014-10-01" version="1">MTFQSKNLENFLLIESSSCPTRIMDKWTNSDDLYKNILRGQGNPLISGPSANFIAGSTAGCTTLVIIYPLDIAHTRLAADLGRTGTRQFRGVSHFLSTIYEKDGIKGIYRGLPASLQGMIVHRGLYFGGFDTIKEIMSEETKPDVALWKRWIAAQAVTTSAGLISYPLDTVRRRMMMQSGLEQPMYRSTLDCWRKIYRTEGFSSFYRGALSNIFRSTGAAAVLVLYDEIKKLMDWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULX1</accession>
    <name>A0A068ULX1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial</fullName>
            <ecNumber evidence="5">1.6.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Internal alternative NADH dehydrogenase NDA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Internal non-phosphorylating NAD(P)H dehydrogenase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">NADH:ubiquinone reductase (non-electrogenic) NDA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00028434001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="5"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULX1"/>
    <dbReference type="FunCoup" id="A0A068ULX1">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULX1"/>
    <dbReference type="Gramene" id="CDP09204">
        <property type="protein sequence ID" value="CDP09204"/>
        <property type="gene ID" value="GSCOC_T00028434001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULX1"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULX1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000009">
        <property type="entry name" value="Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="23">
        <location>
            <begin position="63"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="24">
        <location>
            <begin position="428"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP09204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="498" mass="54531" checksum="FF76D52520FD6A46" modified="2014-10-01" version="1">MPWFRNLIPLSSSTTFGTHSSLKPITTATSLSYAFTHQLLHGAGTVAATYAGLAPTKGDEKARVVVLGSGWAGCRLIKDIDTSIYDVVCVSPRNHMVFTPLLASTCVGTLEFRSVAEPIGRIQPAISREPGSYYFLANSTGVDFQNHLVNCQTVTDGAGTLEPWNFTIAYDKLVIAAGAEASTFGIRGVKEHAIFLREVHHAQEIRRKLLLNLMLSDVPGVSDEEKRRLLHCVVVGGGPTGVEFSGELSDFITRDVRQRYAHVKDYIRVTLIEANEILSSFDDRLRIYATKQLIKSGVRLVRGIVKDVQPEKIVLSDGTDVPYGLLVWSTGVGPSPFVKSLDVPKSPGGRIGVDEWLRVPAVQDVFAIGDCCGFLESTGKPVLPALAQVAERQGKYLAQELNRIGKAGGGRANAAMDIDLGSPFVYRHLGSMATIGRYKALVDLRQSKEARGLSVAGFGSWFVWRSAYLTRVISWRNRFYVAINWLTTLVFGRDISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQR1</accession>
    <name>A0A068UQR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030465001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQR1"/>
    <dbReference type="STRING" id="49390.A0A068UQR1"/>
    <dbReference type="Gramene" id="CDP09953">
        <property type="protein sequence ID" value="CDP09953"/>
        <property type="gene ID" value="GSCOC_T00030465001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQR1"/>
    <dbReference type="OMA" id="YVRMEMP"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044656">
        <property type="entry name" value="HSP14.7/HSP23.5/HSP23.6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46991">
        <property type="entry name" value="23.5 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46991:SF7">
        <property type="entry name" value="HEAT SHOCK 22 KDA PROTEIN, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="88"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="189" mass="20668" checksum="F853326FD8AFDAD5" modified="2014-10-01" version="1">MAFLMAMRRTAASPASSTLFTRFLNGTVLKPSAAGVAPVTTSSITSSIPIILGDEPRVTLNALGGSYPRSEQFPIDRGGYSDEYINPFQTSGSRGAYEINHVDEGLYVRMEMPGIGKEDVKVWNEYGTVYVKGIGNNKQSRFEKLRRAYSATIEIPSDTFHAGKIEVDVKNGVLRMLIPNKESTNLGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR02</accession>
    <name>A0A068UR02_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00031983001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR02"/>
    <dbReference type="FunCoup" id="A0A068UR02">
        <property type="interactions" value="1144"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UR02"/>
    <dbReference type="Gramene" id="CDP10985">
        <property type="protein sequence ID" value="CDP10985"/>
        <property type="gene ID" value="GSCOC_T00031983001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR02"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR02"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000021">
        <property type="entry name" value="Glutamate-1-semialdehyde 2,1-aminomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000012">
        <property type="entry name" value="Glutamate-1-semialdehyde 2,1-aminomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000818">
        <property type="entry name" value="PRK00062.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="437" mass="46786" checksum="1A0130159E5416FB" modified="2014-10-01" version="1">MAVTPVDEKKKAYTLQKSEEAFSKAKELMPGGVNSPVRAFKSVGGQPILFDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDEVLGALAETMKKGTSFGAPCLLENVLAEMVIAAVPSVEMVRFVNSGTEACMGVLRLARAFTGREKIIKFEGCYHGHADPFLVKAGSGVATLGLPDSPGVPRAATFETLTSPYNDIETVENLFKTNEIAAVILEPVVGNAGFIPPKPGFLDALRQITKENGALLIFDEVMTGFRLSYGGAQEYFGITPDLTTLGKVIGGGLPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLKEPGSYDYLNKVTGELIQGIVDAGKKAGHAICGGYISGMFGFFFTDGPVFNFDDAKKSDTSKFARFYRGMLEEGVYFAPSQFEAGFTSLAHTTEDIQQTIAAAEKVFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR20</accession>
    <name>A0A068UR20_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00031525001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR20"/>
    <dbReference type="Gramene" id="CDP10722">
        <property type="protein sequence ID" value="CDP10722"/>
        <property type="gene ID" value="GSCOC_T00031525001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR20"/>
    <dbReference type="OrthoDB" id="2016588at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR20"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47364">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47364:SF2">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16845">
        <property type="entry name" value="SQAPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="3">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="17518" checksum="7F58FB1B747E1A40" modified="2014-10-01" version="1">MAAVVANPHINISEITANMKAEGVQSPEIEAIVKALSDDTIWNTIEGFKGKDMSTQEKMINNMVAGGHLPQVGVPLPTPVNPTDPHVISVAKFAVAKYNDKHGTKLVFNRVNGGLQWKIVIGTLYILVLATQDSKGTYTDYAVVFETFLGQKYLFWYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US17</accession>
    <name>A0A068US17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00033268001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068US17">
        <property type="interactions" value="2672"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068US17"/>
    <dbReference type="Gramene" id="CDP11181">
        <property type="protein sequence ID" value="CDP11181"/>
        <property type="gene ID" value="GSCOC_T00033268001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US17"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="PhylomeDB" id="A0A068US17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001649">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004267">
        <property type="entry name" value="Os02g0497500 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="23">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc-hook" evidence="22">
        <location>
            <begin position="689"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="197"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="507"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="809"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="1039"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1317" mass="153050" checksum="A18A5EFB43561754" modified="2014-10-01" version="1">MSTVDKMLIKGIRSFDPENKNVITFFKPLTLIVGPNGAGKTTIIESLKVACTGELPPNARSGQSFIHDPKVAGETETKGQIKLRFKTAARKDVVCIRSFQLTQKATKMEYKALESVLQTINPHTGEKVCLSYRCADMDREIPALMGVSKAILENVIFVHQDEANWPLQDPSTLKKKFDDIFSATRYTKALEVIKKLHKDQAQEIKQYRLKLENLQTLKDAAYKLRESIASDQDKTESLKSQMQELENDIQHLDNNIHNTEVTLKDLRKLQERIATKTAERSILFKEQERQYAALTEENEDTDEELMEWKSKFEERIAILETKISKLNREMTDTETKISYLKETMDDYVRETSKLQTEAEVHQNLKNDRELKIKRLFERHNLGVVPNSPFSDEVALNLINRVQSRLKDLDNDLDDKKKSNERELEAAFGQYMHANDRWKDVDAQKQAKLEIKRGILKHIEEKENERDSFERQISNVNLSHLDEREKNMRIEMERKTKHLAEREFESSIQKKQSEIHSLEPKIKALNREKDIMVADSEDRVKLSIRKAELENLKKKLKKIMDEHKDKIRGVLKGRLPADKDLKQEIAKVQRASQAEFDDLNSKAREAEKEVNMLQLKIQEVNINLSKLHKDMDSRRRFIESKLHSLAQQSVSIDSYPKALDSSKEKRDVQKRFKYNIADGMRQMFDPFERVARAHHICPCCERPFSAEEEDEFVKKQRVKAASSAEHMKLLSVESSDADSQFQQLDKLRMVYEEYTKIGQESIPLAEKSLSEQNEDLDRKNQALDDILGVLAQVKSEKASVDALIQPVETADRLFQEIQTLQEQVDDLEDKLDFRGQGGKTMEDVQRELDTLQQTKDSLHNDVEKLREEQRYTEMDISSIQMRWHSLREEKLRATNTLNELRKVEEELDRLSEQKNQAELDEKHLAEAASQLEKEKEALLRHHNVLKAKLNCEYEEQAKLKANYQQEAVKLLEITDEIKKYHDLKKGERLKEVQEKHSQSESQFRSFEARKEEISVELNKIKDLMRNQDNVRRGIEDNLNYRKIKAEVDGLAREIELLEEEILKVGGVSAVEAELAKLSKEREGLLSELNRCRGTMAVYRSNISTNQIDLKQAQYKDIDKRYFDQLIQLKTTEMANKDLDRYYNALDKALMRFHTMKMEEINKIVRELWQQTYRGQDIDYISIHSDSEGGGTRSYSYKVLMQTGDAELEMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDAPNSESLAAALLRIMEDRKGQENFQLIVITHDERFAQLIGQRQHAEKYYRISKDDHQHSIIEAQEIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USI8</accession>
    <name>A0A068USI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033639001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USI8"/>
    <dbReference type="STRING" id="49390.A0A068USI8"/>
    <dbReference type="Gramene" id="CDP11401">
        <property type="protein sequence ID" value="CDP11401"/>
        <property type="gene ID" value="GSCOC_T00033639001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USI8"/>
    <dbReference type="OMA" id="ERGGCAN"/>
    <dbReference type="OrthoDB" id="1879717at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47467">
        <property type="entry name" value="OS01G0867200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47467:SF1">
        <property type="entry name" value="WD40 REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34383" checksum="25584792944724C5" modified="2014-10-01" version="1">MLEVQSLKKALVPKSLIPNPSPGNLQSTRLALHVKEDASPPSCWVYVASGCRIYKVLVRMGGSFVYQGKESLLIPQETLVLDSAVLNCCPHRSEIQSIVLAETESSGSFILGSVDSYGHLIVSKLDGSGDDVNNFSFSVSPRDFGAGESGWAGLCFNPSQWSMAAVARSFCKSIDIYDQDIHLRTLRTLWYPSSLIFMNNFYGGSEGSVLAVAEGSQLTVWDLRIKENSGCVHRICGSVGDMVYAVCSSPTGTIAAGGADRTVTVYDPRRWCALSRWLNCSKYEVSYNLVLSKYKFFFSEKVFDELERLVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USJ8</accession>
    <name>A0A068USJ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00033653001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USJ8"/>
    <dbReference type="Gramene" id="CDP11411">
        <property type="protein sequence ID" value="CDP11411"/>
        <property type="gene ID" value="GSCOC_T00033653001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USJ8"/>
    <dbReference type="OMA" id="MACCEES"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USJ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000627">
        <property type="entry name" value="Probable leucine-rich repeat receptor-like protein kinase At2g33170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF73">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655187" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="709"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="995" mass="110201" checksum="E47F40061B8F69AE" modified="2014-10-01" version="1">MENYKKLCIELVLSTCLVVSTLAMSTTNFTTDQLALLSLKQHITSDPGGSILANNWSTAVTVCGWIGVTCSPRHPGRVTQVNIPNMGLAGTIPPDIGNLSFLVSLDMRNNNFHGVLPERMVNLRRLRFIDLRFNNFVGEVPSWFGLLDKLQSLLLSRNQFSGVIPKQIGNLYKLEHLIMSYNNLEGGIPKEICNLTMLKSLVLCSNHLTGSIPQEIGNLIKLENLCLQFNSLTGSIPIGIFNISALQIFSLVRNHIIGNLPPNFGYALHNLEEFVIGGNNLSGVIPRSISNCSKLARLSLGQNKFTGKVPNSIGDLRLLEVLDLSENDLTSDQSESPELSLITSLTYCKSLTRLALAGNPLNGMLPVTIGNLSNSLEKIYARSCRIRGSIPESIGNLSNLIVLSIFDNALTGSIPSTLKGLQKLQGLLLYDNNIEGTIPTNLCNLPSLSTVDVSHNQISGTIPECIGNLTSLRNLHLGFNRLASSVPRSLWNLKDLLELNLTSNVLIGYLPPEIGKLEVVMLLDLSVNRFSDSIPSTIGALENVIRLSLARNAIQGSIPESLSYLLSLEFLDLSHNNLSGSIPKSLEALIFLKYFNVSFNDLRGEIPSNGPFQNFNPESFISNAALCGASRFHVKSCETVAEHRLKHKRNIRIIFVVLGTATVLSAMAFGFLFFRYRKKDIVSSRRNFSSLMSKPRFSYNELFQATDGWNNRNLLGLGSFGSVYKGTFRDGIVLAIKVFNLELEVAFESFDAECKMLSNFRHRNLTKVISCCSNFDFKAIVLEYMPNGSLENWLYSQNHFLDATQRLTIMIDVAYALQYLHHGHSTPMVHCDLKPSNILLSQDMVAHLCDFGISKLLSQESSFTYTQTLATCGYVAPEYGSEGLVSTRCDVYSYGIVLMEVFTRKKPNDEMFGENLSLKSWILDSLPNAIVQVIDANLIRPDKSSFSQELNCISAIMEVAMKCSRDSPRDRSTMGDVLEELKKIKLLLSALDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT34</accession>
    <name>A0A068UT34_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033924001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739140">
        <property type="protein sequence ID" value="CDP11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UT34"/>
    <dbReference type="STRING" id="49390.A0A068UT34"/>
    <dbReference type="Gramene" id="CDP11586">
        <property type="protein sequence ID" value="CDP11586"/>
        <property type="gene ID" value="GSCOC_T00033924001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT34"/>
    <dbReference type="OrthoDB" id="306218at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT34"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="193" mass="22365" checksum="CC56BDFBB706175E" modified="2014-10-01" version="1">MSKNFPEWLSSPPVKATENSLMCSDRVSLRKHTRRHIVCKVENLANRNSKNNSEKVCSRSPFKTPPSLSYCHDKLSSFAHCANLFYLWFRALIELLDEVEDVISIEESVCDKTKAWFDIGRSINELDFIVEQQLINSKELVTKEPSNNYFLVLEVSEKHGNIDSSGLRNSFKIMRVLNEQNGEEKAVHLWDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTK4</accession>
    <name>A0A068UTK4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034012001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739141">
        <property type="protein sequence ID" value="CDP11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTK4"/>
    <dbReference type="STRING" id="49390.A0A068UTK4"/>
    <dbReference type="Gramene" id="CDP11632">
        <property type="protein sequence ID" value="CDP11632"/>
        <property type="gene ID" value="GSCOC_T00034012001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTK4"/>
    <dbReference type="OMA" id="DGNIGEM"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35037" checksum="48CBBC52A33FCAC4" modified="2014-10-01" version="1">MVSTSPPSPEDRISQATVTKAVKALIKWRKLHPRTTQHKPAAGEEEKQEFREDEDGNEEEDFIYLLLTLKKIPPKDSSKIPHTISLPNPLHSLADDNLSLCLIIDDRPIKSPYRITAEFAQKKVKSEDIPIDKVFKLSKLKSDCKSLEGRQKLYRSYDMFFADKRVVSLLPAVLGKQFYEKKRKIPVPLDLRSRDKWKEQIERAVNSALLCFGSGSCSVVKVGKCGGMGSDEIVENVFAAVKGISEVVPKKWDGIRALHLKLSDSLALPVYDGNLGSLNAEDRVEEGDLEGKKNGILELKKMRQGREGALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTZ3</accession>
    <name>A0A068UTZ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035208001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTZ3"/>
    <dbReference type="STRING" id="49390.A0A068UTZ3"/>
    <dbReference type="Gramene" id="CDP11906">
        <property type="protein sequence ID" value="CDP11906"/>
        <property type="gene ID" value="GSCOC_T00035208001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTZ3"/>
    <dbReference type="PhylomeDB" id="A0A068UTZ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000465">
        <property type="entry name" value="Heat shock cognate 70 kDa protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62855" checksum="7F9EFD8B11F9651C" modified="2014-10-01" version="1">MAGKSAPAIGIDLGTTYSCVAVWEHDRVEIIANDQGNRTTPSYVAFTDTERFVGDAAKNQAAINPVNTIFDSKRLIGRKYTDPSVEYDLKLWPFKEKQFAPEEISAMILTKMKEVAEAYLGLPVKNAVITVPAYFNDSQRQATRDAGAISGLNVLRIIVEPTAAAIAYGLDKELLINTGGQKNVLIFDLGGGTFDVSLLTIEKSMVDVKAVGGDTHLGGEDFDNRMVNHFVQAALRRLRSACERAKRILSSIHQTSIEIDALFEGIDFQSTITRPRFEELNMDLFRQCMEPVESCLRDAKMDKHSVQDIVLVGGSTRIPKVQQLLQDFFNGKTLCKSINPDEAVAYGAAVQAAILDGRGNQKALDIAIMDVTPLSLGFECKGKVMTVVIPRNTTIPTKKETTCTTAYDNLTHVLFLVYEGERARSTENNLLGRFTLGGIPPAPRAVPVINVCFDLDANGILNVSAEDKNTGQKSRITISFDKGRLSREEIEKMVQAAEKYKFEDEEHKKKSKNISSSLASADMKKIEDAIEDAMQWLDGNQLGETDEYEDKMKELESITERLMITKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVB6</accession>
    <name>A0A068UVB6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035854001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVB6"/>
    <dbReference type="FunCoup" id="A0A068UVB6">
        <property type="interactions" value="2979"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVB6"/>
    <dbReference type="Gramene" id="CDP12361">
        <property type="protein sequence ID" value="CDP12361"/>
        <property type="gene ID" value="GSCOC_T00035854001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVB6"/>
    <dbReference type="OMA" id="FDEDSRY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVB6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="191" mass="21207" checksum="EE356DDADE8ADC51" modified="2014-10-01" version="1">MVLVLALGDLHIPHRAPDLPAKFKSMLVPGKIQHIICTGNLCIKEVHDYLKTICPDLHITRGEYDEETRYPETKTLTIGQFKLGICHGHQVIPWGDLDSLAMLQRQLDVDILVTGHTHQFTAYKHEAGVVINPGSATGAYSSITYDVNPSFVLMDIDGLRVVVYVYELIDGEVKVDKIDFKKTTASANSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVL6</accession>
    <name>A0A068UVL6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dof-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00035756001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVL6"/>
    <dbReference type="FunCoup" id="A0A068UVL6">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVL6"/>
    <dbReference type="Gramene" id="CDP12294">
        <property type="protein sequence ID" value="CDP12294"/>
        <property type="gene ID" value="GSCOC_T00035756001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVL6"/>
    <dbReference type="OMA" id="PCKGREN"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVL6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31089">
        <property type="entry name" value="CYCLIC DOF FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31089:SF1">
        <property type="entry name" value="CYCLIC DOF FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="10">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="501" mass="54120" checksum="C9B2EFDA4E77431D" modified="2014-10-01" version="1">MKEIMEMKDPEIKLFGKKIALLENGKRILVVVPAAGEDSSSVSGGENSVGSDSDLSMDSRKAEDEKDQEKRETASDKDCPSGKLCSSEPRVKDPIAEELPILKSSSDSDGNSNNYSTDEDSPVKQPPKAENDQSDATDSQQKTLKKPDKILPCPRCNSMDTKFCYYNNYNINQPRHFCKSCQRYWTAGGTMRNVPVGAGRRKNKNSASHCRHITISEALQAARIDTPNGFHHLNFKPNGTVLSFGSDSPLCDSMASVLNLAEKKSPNGSQNGFYKLDHGISVSLKGTENGDDCSSGSSVTTSNSTVDGAKNGLQEPVMQQINGFPSPVSCLPGVPWAFPWSSTVPLPAICPPGFPMPFYPTPFWNCGVPGAWSIPWLPPVFPTGNQKNSGSGPNSPTLGKHSRNGELIKQNNPEGKDSQEQRASEGSILIPKTLRIDDPDEAAKSSIWTTLGINYDSISRGGLFKALQPKGDEKKHLTTASPVLQANPAALSRSVTFQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVZ5</accession>
    <name>A0A068UVZ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00036257001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVZ5"/>
    <dbReference type="FunCoup" id="A0A068UVZ5">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVZ5"/>
    <dbReference type="Gramene" id="CDP12591">
        <property type="protein sequence ID" value="CDP12591"/>
        <property type="gene ID" value="GSCOC_T00036257001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVZ5"/>
    <dbReference type="OMA" id="DTAFYYR"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVZ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000004">
        <property type="entry name" value="Berberine bridge enzyme-like 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658017" description="FAD-binding PCMH-type domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP12591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="538" mass="59621" checksum="D0EC923B6D580FFA" modified="2014-10-01" version="1">MLSLTMFPFLLLLVLFPFFTSISQPFCVAASDSIYDNFASCLTKNGIPSGQISNILYSPTNTSFNSVLQAHVRNLRFNTSSTRKPSIIVAPLEIPHVQAAVLCTKGAGLELKIRSGGHDYEGISYVSDVPFIILDMFNLSSITVDIPSESAWVQAGATVGELYYRIWEKSNAYGFPAGLCPTLGVGGHISGGGYGAMLRRFGLSVDNVLDAQIVDVKGQVLDRKAMGEDLFWAIRGGGGASFGVVLAYKLKLVQVPEIVTVFNVQRTEAENATDILVQWQNVADKIDNGLFIRVLVQPSTSESQKIIRLTFIALYLGDSDSLMSVMNAGFPALGLQKSDCKEGSWIQSMLFWSNFDIGAKPELLLNRTSDVNFLKRKSDYVQTPIPKDALTSIFNKMVQLGKPGLVFNPYGGRMSEIPANETPFPHRAGIIYKIQYSVNWDDASPNITNQYLEQARELYSFTTPYVSSNPRQAFLNYRDLDIGTTDNGKNSYSEGEVYGRKYFKDNFDRLVKVKTVVDPENFFKNEQSIPTLPARSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXQ1</accession>
    <name>A0A068UXQ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TORNADO 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00037791001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXQ1"/>
    <dbReference type="FunCoup" id="A0A068UXQ1">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXQ1"/>
    <dbReference type="Gramene" id="CDP13039">
        <property type="protein sequence ID" value="CDP13039"/>
        <property type="gene ID" value="GSCOC_T00037791001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXQ1"/>
    <dbReference type="OMA" id="ADMDCLN"/>
    <dbReference type="OrthoDB" id="664300at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXQ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044991">
        <property type="entry name" value="TET_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32191">
        <property type="entry name" value="TETRASPANIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30465" checksum="2FA2BC1D79733A40" modified="2014-10-01" version="1">MALSNNVIGCINFVAMLLSIPIIGAGIWLATEPDNSCVKLLQWPVIILGVLILIVALAGFIGGFWRIPWLLILYLIAMLVLIVLLACLVVFIYMVTIRGSGRPATNRAYLEYHLDDFSGWLRRRVQSSYKWDRIRSCLSSSSMCAELNQSYRMPQDFFNAHLSPLQSGCCKPPTQCGYTFVNPTYWISPIDTAADMDCLQWSNEQTQLCYSCDSCKAGLLANLKKEWRRADIILLITLVGLIWVYLIGCCAFRNAKTEDLFRKYKQGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZQ7</accession>
    <name>A0A068UZQ7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038836001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZQ7"/>
    <dbReference type="STRING" id="49390.A0A068UZQ7"/>
    <dbReference type="Gramene" id="CDP13782">
        <property type="protein sequence ID" value="CDP13782"/>
        <property type="gene ID" value="GSCOC_T00038836001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZQ7"/>
    <dbReference type="OMA" id="GPKLMLC"/>
    <dbReference type="OrthoDB" id="2020529at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072598">
        <property type="term" value="P:protein localization to chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34572">
        <property type="entry name" value="GOLGIN FAMILY A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34572:SF1">
        <property type="entry name" value="GOLGIN FAMILY A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="18277" checksum="B4FA184B3D4D194F" modified="2014-10-01" version="1">MEGTGQRLSRFYSRYGLGPAPSAPAFTGPVRKWKRKWVPSEPNKNNAVAGKRGHQHQEQDAPSLLLCRWTPLNSSGESSEPSKRKFRYTPVIAFEEKKKEAVERLDDDAARIEKNQSRADVIMTIDMPFEKPHFNDNFVEEMKEPGEDHAYFENLDLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V058</accession>
    <name>A0A068V058_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00039233001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V058"/>
    <dbReference type="STRING" id="49390.A0A068V058"/>
    <dbReference type="Gramene" id="CDP14051">
        <property type="protein sequence ID" value="CDP14051"/>
        <property type="gene ID" value="GSCOC_T00039233001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V058"/>
    <dbReference type="OMA" id="WDPVNKE"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V058"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000001">
        <property type="entry name" value="Probable aquaporin PIP1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45687">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22439" checksum="7B9D5C7C101052F7" modified="2014-10-01" version="1">MGVSKSDSKCSTVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAFFYMVMQCLGAICGAGVVKGFQKHLYQSKGGGANVVNGGYTKGDGLGAEIVGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNQKPAWDDHWIFWVGPFIGAALAALYHQVVIRAIPFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V085</accession>
    <name>A0A068V085_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Legume lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00039264001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V085"/>
    <dbReference type="STRING" id="49390.A0A068V085"/>
    <dbReference type="Gramene" id="CDP14076">
        <property type="protein sequence ID" value="CDP14076"/>
        <property type="gene ID" value="GSCOC_T00039264001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V085"/>
    <dbReference type="OMA" id="MLFMWAI"/>
    <dbReference type="OrthoDB" id="2019747at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V085"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050258">
        <property type="entry name" value="Leguminous_Lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32401">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32401:SF54">
        <property type="entry name" value="L-TYPE LECTIN-DOMAIN CONTAINING RECEPTOR KINASE S.4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655428" description="Legume lectin domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Legume lectin" evidence="5">
        <location>
            <begin position="32"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="348" mass="37921" checksum="5A41DDB2346C76AA" modified="2014-10-01" version="1">MAAFSILNFTIAVLLVFLSRTSSTPLPYAPKFDPNLLLIGDARLTNSASSVQLTDPTSSSSSGLLIRSKTFKFRSSNSKKPATKPASFSTDFIFSISPHDGDGLALIIVPADFSSKFSRDGFGLSRQSRFFAVEFDTFRNENVGDENANHVGIDVASLHSVQVSNVSSIGLVLNSGIKLHSWVDYDSSSKRLEVRLSGFGSPRPYAPLLAYQIDLGEMWKGEEVLVGLTSSRGNSVQKTCIYSWKFTVRIAPNWLHSQPVNPQAFTSKRSEDKVADKKSLCALRLLSGLIFATGCGLLAAFVVLFLWAVFANNDQVAVIPVKCSANPGDFRYEKIQVVLEDSSDAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V098</accession>
    <name>A0A068V098_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00038184001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V098"/>
    <dbReference type="FunCoup" id="A0A068V098">
        <property type="interactions" value="2352"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V098"/>
    <dbReference type="MEROPS" id="M03.A03"/>
    <dbReference type="Gramene" id="CDP13293">
        <property type="protein sequence ID" value="CDP13293"/>
        <property type="gene ID" value="GSCOC_T00038184001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V098"/>
    <dbReference type="OMA" id="MYTREGK"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V098"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000032">
        <property type="entry name" value="Probable thimet oligopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF82">
        <property type="entry name" value="THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="260"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="699" mass="78865" checksum="F5D1B155F2ECC59C" modified="2014-10-01" version="1">MAERRDKREQKVGKLIALTGAAAFIAIAVNSAVSAINSYSKNRRRKEVRGSKVQINLSASEILKLADRVIAKSKGVYDAVASVPLDKVTFANVVLPLAELEAQQFPLVQSCVFPKLVSTSEDVRKASAQAEQRIDAHISICSKREDVYRVIRALMARGDWMSSEAKRFTQSLVQDFERNGLNLTLTKREEVQRLKTQIDELSMLYICNLNDDRTCLHFSKNELAGLPLEFLKTLDEAEKGKYKISLRSHHVSPILELCKVGSTRKAVAVSYGGRSEANVDILEKLIQLRHKLARLLGFSSYADYAIDHGMADSSTKVFEFLEDISGNLTEQASRELAILRQLKKQEEGELAFGIEDLPYYVRRARDQQLDFDYGVVKQYFPVNLVLSGIFKICQDLFGLRFELVADAEVWHSDVQLFSVIDSISGELMGYFYLDIYSREGKYAHTCVVALQNGSSISCGRLIPVVLLISQFEKEVEGHPGLLRFSEVLNLFHEFGHVVHSICNCATFARFSGLRLDPDFVEIPARLLENWCYERLSLKLISGFHQDISKPIDVKICESLRQWRCSFSALKLKQEILYCLFDQIIHSAENVDMVELYKHLHAKVMLGLPMLEGTNPASCFPGSAIGYEATCYRRIWSEVFAADIFASKFSDDLFNQYTGMQFRSKVLAPGGEKDSLQVLSDFLGREPSIHAFLDTKADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0Y4</accession>
    <name>A0A068V0Y4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00040404001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0Y4"/>
    <dbReference type="Gramene" id="CDP14159">
        <property type="protein sequence ID" value="CDP14159"/>
        <property type="gene ID" value="GSCOC_T00040404001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0Y4"/>
    <dbReference type="OrthoDB" id="202851at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0Y4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36058">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36058:SF1">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20863" checksum="2834D51514A5EF93" modified="2014-10-01" version="1">MSLLFAWMQLVEQDSKGQCNSECKTIDELVKRSWGIRILIGACSKKPPKVPEDRIPGEPFVPKSSKEAEMEKIPKSMEGMPGAPGMKMYSKEDLMNTKNFGDDDVDEEDDEDEAQFPSNLGKVLREKENKKDDWTRRITKGILNAGETVKNHANKVSHRIRKWWKAKKAVLNKKNSNAKKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1Z0</accession>
    <name>A0A068V1Z0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">eIF-4F p26 subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00041107001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to interact with other partners. In higher plants two isoforms of EIF4F have been identified, named isoform EIF4F and isoform EIF(iso)4F. Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has subunits p82 and p28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1Z0"/>
    <dbReference type="FunCoup" id="A0A068V1Z0">
        <property type="interactions" value="2559"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1Z0"/>
    <dbReference type="Gramene" id="CDP14577">
        <property type="protein sequence ID" value="CDP14577"/>
        <property type="gene ID" value="GSCOC_T00041107001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1Z0"/>
    <dbReference type="OMA" id="QTEFKMM"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1Z0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP14577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="229" mass="26092" checksum="7148190DBF66AE20" modified="2014-10-01" version="1">MVEELEKPMAEEKEEKIPPVEDDEGPEEGEIVEESEETGSSSMGNPSKSLVTKHPLEHSWTFWFDNPSAKSKQIAWGSSIRPIYTFSTVEDFWGIYNNIHHPSKLAVGADFHCFKNKIEPKWEDPVCANGGKWTVNLQRGKSDTSWLYTLLALIGEQFDYGDEICGAVVNVRSRQEKIALWTKNAANETAQISIGKQWKDFLDYNDQTGFIFHEDAKKLDRAAKNRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2E7</accession>
    <name>A0A068V2E7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042120001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Ixoroideae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Cenci A."/>
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                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
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                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Perrotta G."/>
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                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
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                <person name="Albert V.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Crouzillat D."/>
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                <person name="Rigoreau M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Pietrella M."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Crouzillat D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V407"/>
    <dbReference type="FunCoup" id="A0A068V407">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V407"/>
    <dbReference type="Gramene" id="CDP15214">
        <property type="protein sequence ID" value="CDP15214"/>
        <property type="gene ID" value="GSCOC_T00042842001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V407"/>
    <dbReference type="OMA" id="PGRFVCN"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V407"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.20:FF:000003">
        <property type="entry name" value="Pyrrolidone-carboxylate peptidase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP15214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23799" checksum="88BBE9FB8E923478" modified="2014-10-01" version="1">MGSEGPPAVTIHVTGFKKFHGVAENPTETIVSNLKEYVKKRGLPKGVILGSCSILETAGQGAVVPLYQTLQSAISTAENESSTPGRVIWVHFGVNSGATKFAIENQAVNEATFRCPDEMGWKPQKVPIIPADGGISRARETSLPVEEITKALAKMGYEVMTSDDAGRFVCNYVYYHSLRFAEQNGIKSLFVHVPLFFTIDEETQMQFAASLLEVLASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4A9</accession>
    <name>A0A068V4A9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00043132001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4A9"/>
    <dbReference type="FunCoup" id="A0A068V4A9">
        <property type="interactions" value="1675"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4A9"/>
    <dbReference type="Gramene" id="CDP15407">
        <property type="protein sequence ID" value="CDP15407"/>
        <property type="gene ID" value="GSCOC_T00043132001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4A9"/>
    <dbReference type="OMA" id="CHTLANF"/>
    <dbReference type="OrthoDB" id="1891924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4A9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF256">
        <property type="entry name" value="OS07G0242900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="419" mass="47841" checksum="E0112A32596EEBCB" modified="2014-10-01" version="1">MERLPVEVIGNILSRLGAARDVLIASATCRKWREAWKYHLHALTFNSNDWPVYHDLTTTKLEIIITQTIFQTNALQRLSIIMDHVDEFSAAPVIAWLMYTRDTLRQLHYNVTTTPNINILEKCSRHKLEVLRLAHNTITGVEPTYQKFPCLRLLALSYVIISALDLSLLLTACPKIEVLTLVSLDVVMSDPQATMELSSNSLKDIYVEAISLDKFILEADSLEKLHLKDCTLEVFELVCKGSLKLLRIDDVSVIHLDIGESAENLEVVDVGNFTIMWAKFHHMISKSSKLRRLRLWGVVFDDDDEIVEIETISACFPLLSHLSLSYDLREAALQYGLQGSFQLENIVVLELGWTVITDLFSHWVAGLLERCTILRKLVIYGIVSETKTPEECHALANFSSFMIKLMRKYPDVEVQFIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4E7</accession>
    <name>A0A068V4E7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00043113001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4E7"/>
    <dbReference type="Gramene" id="CDP15394">
        <property type="protein sequence ID" value="CDP15394"/>
        <property type="gene ID" value="GSCOC_T00043113001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4E7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="104" mass="11616" checksum="67266D5C9F651280" modified="2014-10-01" version="1">MRIIFAASAVALQTAPQLIHSSLTPTLKPGTRHSTRTQSLLELSMDGCGLTCYALNSTFPRIRSDDCSLSLSLYSKYVHAHVPKNCLKWRRVFAGLLVLRIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5S8</accession>
    <name>A0A068V5S8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016783001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5S8"/>
    <dbReference type="FunCoup" id="A0A068V5S8">
        <property type="interactions" value="947"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5S8"/>
    <dbReference type="Gramene" id="CDP15879">
        <property type="protein sequence ID" value="CDP15879"/>
        <property type="gene ID" value="GSCOC_T00016783001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5S8"/>
    <dbReference type="OMA" id="VTEIEIC"/>
    <dbReference type="OrthoDB" id="685075at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5S8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053342">
        <property type="entry name" value="Exosome_cofactor/PTGS_suppr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37260">
        <property type="entry name" value="PHOSPHORELAY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37260:SF2">
        <property type="entry name" value="PROTEIN ECERIFERUM 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="410" mass="44388" checksum="1755D19745BAB574" modified="2014-10-01" version="1">MDAKALAKSKRAHSLHHSKKHHSSPTSKATPSSATSSSGKKPTNKQARDKPYQSQSSKALPTNWDRYEEEYGSGSEDSPQVSTGQASDVVVPKSKGADYAYLISEAKAQSQANSSSESFSLFDDFLDGFNQGLGSLLSVRGEHLLSRISNDVFPFDDKGTSSHEASFLSLNLHSLAEQLSKANLAERLFIEPDLLPPEMCTELDANNEKNPDELQATGSTEATESEFAGQPSSIISKENRNILLSQEYMSSNSSRVSQFSVPTSTDHRADDLKEISRSTSVKLTSGVSIDSSSEKPSRFEAAKAEAELDMLLDSFGETKFFDSKGSTFQSVSVAAQHVREGPDATYSGRMDAALDDSLDDILKDTSHLINTKAVSPLNEVKAASNEGPTASQPHSKSKILDDFDSWLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V853</accession>
    <name>A0A068V853_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00017144001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739201">
        <property type="protein sequence ID" value="CDP16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V853"/>
    <dbReference type="Gramene" id="CDP16103">
        <property type="protein sequence ID" value="CDP16103"/>
        <property type="gene ID" value="GSCOC_T00017144001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V853"/>
    <dbReference type="OMA" id="WAMLLMM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V853"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF22">
        <property type="entry name" value="CYTOCHROME P450 83B1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655649" description="Cytochrome P450" evidence="14">
        <location>
            <begin position="24"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57003" checksum="CBC4DADA03F9F6D2" modified="2014-10-01" version="1">MEFLILLVFPILLVMLLLLPNKTKKPSRVHHSPTGPPRLPLIGNLHQIDPSCLHKYLWKLSQKYGPLMFLKLGSVPTLVISSARLAEEVMKNQDLIFCSRPKMLGLQKLAYNGLDIALAPYNQEWREMRKICVIHLLSAKRIQMFRPIREDEVSRVIGQISKKAASYDQVINLSETIVSLTNTMICRIAFGKRFDEDGHERRRFSSLLHEAQAMFVAFFFSDYFPSVGWIDKFTGTLSRLESTFQKFDSFYQGLIDEHLNPNRPKSMDGDIIDLMLQLQHDGSTSFEITMDHIKAMLMNVFIAGTDRSAVTVIWAMTAMIKIPTVLKKLQAEIREIMGKKQMLDEDDVQMLPYLKAVVKETFRLYPAVPLLVPRETMGKCTIDGYEIQPKTLVYVNAWGIARDPEYWGNPDEFLPERFLNSTIDLKGQDFHLTPFGAGRRGCPGYSMGLATVELVLANILHSFDWELPPGVKKEDIDTDALPGITMNKKTDLRLVANLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V891</accession>
    <name>A0A068V891_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BURP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017220001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V891"/>
    <dbReference type="STRING" id="49390.A0A068V891"/>
    <dbReference type="Gramene" id="CDP16143">
        <property type="protein sequence ID" value="CDP16143"/>
        <property type="gene ID" value="GSCOC_T00017220001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V891"/>
    <dbReference type="OMA" id="YCHELEA"/>
    <dbReference type="OrthoDB" id="654134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V891"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF2">
        <property type="entry name" value="BURP DOMAIN PROTEIN RD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01045">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655651" description="BURP domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="BURP" evidence="2">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="308" mass="34639" checksum="180FB87C1C5E66C3" modified="2014-10-01" version="1">MEFLKLLYFLSFLFLGVGANHADLEAYWKSELPNTPMPKAVRDLIKDGKLPERVRLRPGATPVLTTYGVRYRFSIYGRNPTEDELHIDPKVKVFFLKMDLNRGSSMNMKFVESVKSPTAFLPRQVANSIPFSSKSVPEILNKYSLNPQSQDAGIIKETIAECEVPAMKGEDKYCATSLESMVDFTTSKLGKDVLAISNEAQKTDAKVQKYGIVSVSKLNNNDKEIVSCHRQNYFYAVFYCHTTQDTDAYMVNLVGADGAKVKAAAVCHRDTSAWNPKHLAFQLLKVKPGTVPICHFLPEDHIVWVPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8J9</accession>
    <name>A0A068V8J9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00019453001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glutamate-gated receptor that probably acts as non-selective cation channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739223">
        <property type="protein sequence ID" value="CDP16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8J9"/>
    <dbReference type="FunCoup" id="A0A068V8J9">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8J9"/>
    <dbReference type="Gramene" id="CDP16877">
        <property type="protein sequence ID" value="CDP16877"/>
        <property type="gene ID" value="GSCOC_T00019453001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8J9"/>
    <dbReference type="OMA" id="FANNTPD"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8J9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13686">
        <property type="entry name" value="GluR_Plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19990">
        <property type="entry name" value="PBP1_GABAb_receptor_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000037">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000054">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000175">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000081">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044440">
        <property type="entry name" value="GABAb_receptor_plant_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017103">
        <property type="entry name" value="Iontropic_Glu_rcpt_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037090">
        <property type="entry name" value="Iontro_Glu-like_rcpt_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658675" description="Glutamate receptor" evidence="16">
        <location>
            <begin position="19"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="463"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="749"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037090-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="901" mass="100603" checksum="BBA5C04378E2CC12" modified="2014-10-01" version="1">MSLTWLYPVSILFLAGFSEEIQQSGVINIGSILSFGTINGRVAKIAMTAAVEDVNSDSSVLGGRKLVLSMHDSNYSGFLDIMGALQYMETDTVAIIGPQTSVMAHVIAHFANELHVPLLSFTALDPSITPFQYPYFIQTAPTDLYQIAAIADMISYFGYREVIAIFTDDDKNRNGITILGDILAERRAKISYKATIPPEPAPIRDHVMEELLNIRMMEPRVIVVNTYTKTGFMVFDIAQNLGMMDKGYVWIATNWLSAAMDATQILPDTANSIQGVLTLRLHIPDSKRKRAFASRWNKLSNGSIGLNTYGLYAYDTVWIIANAVKLFLAHGSTISFSNYSSLNVLGGRVLNLSALSIFDGGQMLLSNIVQTNMRGLTGPIEFNPDRSMKRPAYDILNVIGNGFRQIGYWSNYSGLSVDPPETLYSRQANRSSSNQKLYGVLWPGKTEVKPRGWVFPNNGKRLRIGVPNRVSYKDFVSLDNHTGLIHGYCIDVFLAAIKLLPYAVPHEFILFGDGLKNPSYTELVRMITSNVFDAAVGDIAIVANRTKIVDFTQPYIESGLVVVVPVRKLHSSAWAFLRPFTPSMWGVTAAFFLLVGVVVWILEHRVNNEFRGPLKKQLVTLLWFSFSTMFFAQRENTMSTLGRIVLIIWLFVVLIINSSYTASLTSILTVQQLSSSINGIESLITSNDPIGFQVGSFAENYLREELDIAKSRLVPLGSPEAYADALERRIVAAVVDEQPYIDLFLSKYCKFRVVGQPFTRSGWGFAFPRDSPLAIDMSTAILSLSENGELQKIDDKWLNKSMCGPQPQSSQSDQLNLESFWGLFLVCGVAFLIALLVYFWLMFCKFKQHCPETSESSRFGSSYSAHFQRFLSFVDQKEEITSNRLKRKRTGNSTVCQGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9T4</accession>
    <name>A0A068V9T4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="11">HIBADH</shortName>
            <ecNumber evidence="4 11">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00003766001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="4 11"/>
    <dbReference type="EMBL" id="HG739237">
        <property type="protein sequence ID" value="CDP17292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9T4"/>
    <dbReference type="FunCoup" id="A0A068V9T4">
        <property type="interactions" value="1712"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9T4"/>
    <dbReference type="Gramene" id="CDP17292">
        <property type="protein sequence ID" value="CDP17292"/>
        <property type="gene ID" value="GSCOC_T00003766001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9T4"/>
    <dbReference type="OMA" id="MGKKVWH"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9T4"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006551">
        <property type="term" value="P:L-leucine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000119">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="12">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="13">
        <location>
            <begin position="217"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP17292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="351" mass="37779" checksum="9372C962B0224470" modified="2014-10-01" version="1">MAISRLRFLLHQQLQKYTSSLRHLSYSNRSFCSASNLRSHFQRIGFIGLGNMGSRMANNLIEDGYNLTVHDVDHNAMKIFSERGILTKESPFEVADSSDVLITMLPSSNHVLDVYTGRNGLLSHGNTLGPWLFIDSSTIDPQTSRKLSATIADCSLKRKRDGFEVPAMLDAPVSGGVLAAQAGTLTFMVGGLEEAYVAAKPLFLSMGKSTIYCGGAGNGSAAKICNNLAMAVSMLGVSEALALGQKLGIAASTLTKIFNSSSARCWSSDAYNPVPGVMDGVPASRNYDGGFASKLMAKDLNLATESAKEVGLEFPLTSQAEKIFTQLCNDGHGMKDFSCVFRHYYPGNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCK2</accession>
    <name>A0A068VCK2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00002783001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739243">
        <property type="protein sequence ID" value="CDP17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCK2"/>
    <dbReference type="Gramene" id="CDP17413">
        <property type="protein sequence ID" value="CDP17413"/>
        <property type="gene ID" value="GSCOC_T00002783001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="307" mass="34072" checksum="6BA1EB2448921444" modified="2014-10-01" version="1">MFHKLNFFRAVSAVENLDVFTITKKMGNLSLDDKNTSSSSNLSLVSRSDVPNTMPMFSSTSSILERFKRSSKHSEFTRKVMDLTKSPFMDIPKTVMDLTSNSASYLLSLGFRFMPGQGEFLFKNLRLPDTLDGLKGLRENLGLTLAKDTLTNRGILKFKGLSEIHAKGSLMMNRVLLEAITYNDGFYGRFLVLAQIGVGCTVWYGFTPGDGFNIPFDASLTSLFSPIENYEPFFYNPDVYIHPGFQKMTLMENQANTISALSTAYTDEKPFLDIKIPTNSNSNLIVGITLGLVVVVLLSVGLSPIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDT6</accession>
    <name>A0A068VDT6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00002658001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739362">
        <property type="protein sequence ID" value="CDP18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDT6"/>
    <dbReference type="STRING" id="49390.A0A068VDT6"/>
    <dbReference type="Gramene" id="CDP18727">
        <property type="protein sequence ID" value="CDP18727"/>
        <property type="gene ID" value="GSCOC_T00002658001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDT6"/>
    <dbReference type="OMA" id="LMCKICS"/>
    <dbReference type="OrthoDB" id="678085at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDT6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36892">
        <property type="entry name" value="OS01G0201800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36892:SF1">
        <property type="entry name" value="OS05G0518200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133472" checksum="3E28E8F910884260" modified="2014-10-01" version="1">MRSVDVAKCWPFDEANEADVRAALPPMTIKKFRWWFDELKLADGNNKAEEDDDQEEESDLEETTLECLRRMKRVRKGKSVKVVKVVKSKKAKPKVKAPKKRSIVELFAVAPQVDRLNSDDDENGECSDDGEDGDEGSGEEAGIVDAGLRKRKVKKKGILSMLKKEKTVMIKNLKNKDGVNKKKKMEKGKNAAVELRSPKKEKTSKLKLQTSANSVANANCSTYSKDLFEAIAAHVKKPRLKRLTKEKMKCKTPSTSKLLQNDQQAVSPVRGILKNHRRVIPAENSTDSIFYDAGILTNSSTQTVNKHVSFSRSDDVLELKRKAYPTVELETQTFSDSTSDISAASVEKGHPSERGKSLSIQEMKETELGISNSAAAEADVQLMTENLLSGRYHEADAPNFFSRQHGFSQGNWLNRSVSFGQGPLHIESPQWLKGCNRVTACDALYTSSSGIPSLSQERNIPKFTVPMYGYLSDASSSSRRLLDLSGDAGPDLDSSCSMDCLKAYPQPVSSYFSIQHENANARPLFSSQSIRENHNDHAFPYQWFPHLSPKELMHTICSLPDWNSRVAMCGEIGISENFIGLPLNSQGEFISLNSSGKDCLNPLKSMSTLRGPSLSSPMHENILSNSIINHIDIRSWNGMAPFKNQVQSCRIKDSGKEAANCDLPSGFDMFDQYGTGRTNTVMKGSDPDLYSLESDMDRMKVSQFEPRHNYEVQKHPRDEIIQQHGNSDHISVHVTQSTMRLMGQEFTIGGRGFEGLEDRELWMDKQIITDCSNNNGIETSSIKSPHMPEFIVHPILGKLKGTATYVSEAEMKQASEGAPPMMVPESKTSLHFSDSHNNVMQQHWDGLSKGILKPEKYPQFSLVSSLLSDSHKSTLENKFSCSYISPVERPGVSIPGSTLLNCSENMSRSRAQLENKHTSVPPAQLALKFPFSHSECGMHTEPSWSQNSFRVMHPGFLETRKKASLMGYRQSHSGPGTVCHPCSMSGINFQTGPSSFPRPEPFLLFPSSGSENAFASTSLVHCPSVPTHPGFSSNSSMQNRVGEKVNFGSQVESGFSVRIPAHGKRSKKRVPSVSGDCVRSSKIPKIGIQEDSSCAVTAVQSANNFQGDAGCGRQVLELGSAEQNAVTVECGHNGIHVDELGDCTETGPFKLTGAPRSGPMKLTAGARYILKPCQKNDQANSKSTNSIIPVATPATGRRVLGSEKSSKIYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDX8</accession>
    <name>A0A068VDX8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_333</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00000211001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739417">
        <property type="protein sequence ID" value="CDP19040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDX8"/>
    <dbReference type="STRING" id="49390.A0A068VDX8"/>
    <dbReference type="Gramene" id="CDP19040">
        <property type="protein sequence ID" value="CDP19040"/>
        <property type="gene ID" value="GSCOC_T00000211001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDX8"/>
    <dbReference type="PhylomeDB" id="A0A068VDX8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF42">
        <property type="entry name" value="ELONGATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658537" evidence="1">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="106" mass="11625" checksum="D4A2653975C88CF4" modified="2014-10-01" version="1">MLIRLQKISLRCVCLCVFFTFGSVFSGKSATGMKVRIMGPNYVPREKKDLYVIMLRLKNETVEDVPWGNIVAMVGLDQFITVAIVAMVAVSPVVRVAGQSAVEGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VER2</accession>
    <name>A0A068VER2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00009319001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="6"/>
    <dbReference type="EMBL" id="HG739501">
        <property type="protein sequence ID" value="CDP19310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VER2"/>
    <dbReference type="FunCoup" id="A0A068VER2">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VER2"/>
    <dbReference type="Gramene" id="CDP19310">
        <property type="protein sequence ID" value="CDP19310"/>
        <property type="gene ID" value="GSCOC_T00009319001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VER2"/>
    <dbReference type="OMA" id="QRAHVVN"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VER2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22583">
        <property type="entry name" value="Rcat_RBR_ARI7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23141">
        <property type="entry name" value="RING-HC_ARI6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000005">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="134"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="17">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="518"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP19310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="589" mass="67048" checksum="8C4144F1D06B6998" modified="2014-10-01" version="1">MESEDDMHDANDAESGDDDFYSGMDSDGDYDYDYGAADYEFMGNEIDDSDDIIDSRGQKSYTILKEEDIRQRQEDDIMRISTVLSVSREVACLLLRRYNWSVNNVHEEWFAHEERVRLAVGLLEKPVVQSSNAKEVACGICFENYPLDKISAPACGHSFCNTCWQAYISTSINDGPGCLTLRCPDPSCYAAVGQEMIARLASDENKDKYYRYLLRSYIEDNRKTKWCPAPGCDHAVEYVVGSGSYDVTCSCSYSFCWNCTEEAHRPVDCETVAKWILKNSAESENMNWILANSKPCPKCKRPIEKNQGCMHMTCTPPCKFEFCWLCLGVWSEHGERTGGFYACNRYEAAKQEGVYDEAERRREMAKNSLERYTHYYERWATNQSSRQKALADLHLMQTVHLEKLSEIQCQPESQLKFIIEAWLQIVECRRVLKWTYAYGYYLPEHEHTRRQFFEYLQGEAEAGLERLHQCAEKELQNYLQAEGPSKDFNDFRTKLAGLTSVTRNYFENLVRALENGLSDVDSQGSCSKTSSSKNATASSKGKGGGKGKGSSKTGGSSRNLDDSGNWACDQCTYSNVKSATACQMCQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFG0</accession>
    <name>A0A068VFG0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00005643001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739488">
        <property type="protein sequence ID" value="CDP19279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFG0"/>
    <dbReference type="STRING" id="49390.A0A068VFG0"/>
    <dbReference type="Gramene" id="CDP19279">
        <property type="protein sequence ID" value="CDP19279"/>
        <property type="gene ID" value="GSCOC_T00005643001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFG0"/>
    <dbReference type="OMA" id="YLTCIMI"/>
    <dbReference type="PhylomeDB" id="A0A068VFG0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000719">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF163">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="ARM" evidence="19">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="649"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP19279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="880" mass="96632" checksum="F2D060BA9D25CD79" modified="2014-10-01" version="1">MELGENQLNGSIPASIGNLSNLQVLYLQNNQFSGSIPTTFGNLSSLQFLYLYQNNLTGTIPKSLGNLTNLIELDLSDNQLNGSIPISIGSLSDLERLALQYNQFSGTIPQELGNLILDFIDLSNNKFYGKLSSKWGKCKMLKTLIVAKNNITGGIPPEIGNLTQLHKLDLSSNYLSGEIYRGKLGNLGVLMEFLDLSTNSLNGTLPELLGDLKHLFHMNLSNNVLSQKIPLQIGKLTQLSELDLSQNFLTGEIPFEFQNLQSLGALDLSQNNLSGLIPKALAELPGLLHINLSFNNLEGPIPSGGCNLELLYLYNNQFSGSIPVTLAISIGCSLQFLYLYQNNLTGAILKSLGNLTNLIKLVLSENQLSGAISVSIGNLSNLRDLNLLENQFSGTIPQEIGDLKKLASLELDYNQFSGPLPELLCKNGMLQTITVSENMLTEMFGIYPFLDFIDLNNNEFYGELSSNWGNCKLLQILMLAKNNITGGIPPEIGTLTQLQALDLSSNYLSGEIPKAVGKLASMLKLDLHHNQLAGGIPQEFGLAQLSELGLSQNLFTGEIPSEFQNLQSLGTLDLSQNNLSGLIPKALAELPGLLHINLSFNNLEGPIPSGRAFVNLTLEEVKGNKGLCGNITGLRASLYKEIVRSTEEFSETFCIGKGGCGSVYKAQLPSGEVVAVKRLHNVPNMAKDKSFLNEIRALTEIKHRNIVKLFGFCSNAQHSILVYELNIIKGSLMLYLTCIMIVHHQLYTETYQATTFCLIQNVRLTFQILALPSFSEETHLTGVLLQAHMDMLHQCDVYSFGVLTMEVIKGKHPGDLIANLMSSKLEEIELKDLLDQRLLYPNQQIEKSVISIVKLATECLHVDPQCRPTMLIISRLISTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFG9</accession>
    <name>A0A068VFG9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00007256001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739319">
        <property type="protein sequence ID" value="CDP18438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFG9"/>
    <dbReference type="FunCoup" id="A0A068VFG9">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFG9"/>
    <dbReference type="Gramene" id="CDP18438">
        <property type="protein sequence ID" value="CDP18438"/>
        <property type="gene ID" value="GSCOC_T00007256001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFG9"/>
    <dbReference type="OMA" id="KEFAMEK"/>
    <dbReference type="OrthoDB" id="778453at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFG9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36800">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36800:SF1">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13457" checksum="2FC6E97046A3835B" modified="2014-10-01" version="1">MADATSSSPSRSPANAELALPRSDVESQLSSLLYDLSHRVQAAMEHMLKMINEIDQNSSDVMDDIKNCKDFALDRKRTLDEEKEHYQKAAYTVISMLNNQVISKGLILTALFKFLGLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGX4</accession>
    <name>A0A068VGX4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_701</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00005847001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739785">
        <property type="protein sequence ID" value="CDP19809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGX4"/>
    <dbReference type="FunCoup" id="A0A068VGX4">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP19809">
        <property type="protein sequence ID" value="CDP19809"/>
        <property type="gene ID" value="GSCOC_T00005847001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGX4"/>
    <dbReference type="OMA" id="GMYGEGK"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF533">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="641"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP19809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="733" mass="83479" checksum="6F1271508C843B34" modified="2014-10-01" version="1">MNTRKLCSLSARSRDFFYTSLSNALSSATNQRNLRRIHSLIITLGLHNSVLFSGKLISKYSQFKDPLASLSIFEQRSHKKNVYLWNTIIRAMTHNGLYSTALDFYTQMRELRIVPDNYTLPSVINSCANLLDFETAKLVHDHVLDVGFGSDLYICNALIDMYSRLNNLGRARNVFDGMSKRDLITWNSLISGYSSNGYWDEALEFFYKLRMVESIRLFFQMVLDFEPDTITLSSVLQACGHVRDLKSGRSVHDYMVKNRYTGDITANNLLINMYTKCDELLASREVFDSMKSRDLVSWNSMINMYAKVGELDNSLKQFENMEARDVVTWNTIIAACGHCEDCSLGLRMISRMRNEGITFEVPTLLSTLSLCSFLGAKRQAKELHGCIFRLGFESDVSIGNAVIEMYSKSGILWYSRRVFKLMKTKDVISWTALISAYGMYGEGMKALKVFQKMKKVGIAPDHVVFVAILFACSHSGLVQEGWDCFYQMKNDYSIEPRKEHYACMVDLLSRSGLLAEAEDFILSMPQKPDASIWGALLSACRCSGDIKIAERVSERLLELNSDDPGYHVLASNVYAALGKWDKVKMIRKSLRARGLKKQPGFSWLEIQNRVYIFGTGHRFFEQYKEVHDFLVVLSDLMAKEGYVADLRFALHDVEDDEKVDMLCGHSERLAIGFGVLNTEPGSPLQIMKNLRVCGDCHTATKYISKILQRVILVRDANRFHIFKDGTCSCGDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHK4</accession>
    <name>A0A068VHK4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00001651001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739445">
        <property type="protein sequence ID" value="CDP19148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHK4"/>
    <dbReference type="STRING" id="49390.A0A068VHK4"/>
    <dbReference type="Gramene" id="CDP19148">
        <property type="protein sequence ID" value="CDP19148"/>
        <property type="gene ID" value="GSCOC_T00001651001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHK4"/>
    <dbReference type="OMA" id="CKGGHHH"/>
    <dbReference type="OrthoDB" id="1892624at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044956">
        <property type="entry name" value="SKIP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36024">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN SKIP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36024:SF1">
        <property type="entry name" value="OS11G0246900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="421" mass="45980" checksum="904E8D8A47CE293F" modified="2014-10-01" version="1">MSLADTVTVMAQRLHERLQECNGDEILKAEAGAKVQKFTEWALKCIGFHSRSQGNRDRVGQNSAVEIQLQLSAFKTFLDLAGNHLTGKDFTEAFDAACFPLTLFSTSFDPGWATGTSANAIQGLLAMLVEGGADNVNQCFLEASRFGSTELVRILLQIAQRNSLDVDVDLALGFASHYGKIGTMQCLVEEGNAMAFLGPLMRAAERGCMPVVQWFVERGCRDMELCLALTAATSSSQVEVAAYLLPHVPKHILAALSIEILKAAAERSGRSLDGVSFLLQSDFLGEPAATYAVADSIARSNDESVAPELRAFLKEHWSEAAFLDGLKQGQEHYMNLVRIVKWGESPICLRDLPGPLRVAIAYLPLYRECRKAGGCLLSQRRRGQLVEAARRLGGVELEEASQGRQLLAVLEHHLPSFLLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHY0</accession>
    <name>A0A068VHY0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_1102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00008109001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740186">
        <property type="protein sequence ID" value="CDP20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHY0"/>
    <dbReference type="Gramene" id="CDP20326">
        <property type="protein sequence ID" value="CDP20326"/>
        <property type="gene ID" value="GSCOC_T00008109001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHY0"/>
    <dbReference type="PhylomeDB" id="A0A068VHY0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="181"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="425"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="670"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="990" mass="112064" checksum="3818A1EF335ECC7A" modified="2014-10-01" version="1">MADPVIGATIQVTLERARSLASDRIGLLVGFKKDVAGMTRSLRLINAVLADAEAKQNQDGAVQEWLKSLEEVSYDATNVLDELHYEALRHQVESRNRHKRKVCRFFSFSNINLAFRWRMASKVRDVKLKLNGIYQDAHGLGLDSRAVLTAALPAAADAGDRRNRQTDSVAIPMIGRADDESKILEMLLGPSEKVVSGLPITGMGGLGKTTLAKSIYNNQQIDGQFEKKVWVCVSKKVPTVELFKLILVHLTGEKVEVDVRDVIVGKIRNQLGGKRYLLVLDDVWDDNQALWDDFFTTLKGLNPINPPKGSWCLITTRLHLVADKGYSLGRLPGDHCWSILKGKVVDGEEVPNELDAIKDRAIQICNGLPLVASVLGGLLRLRKDKWRSILEDRLLNLNGVMQILQLSFDNLPSPAIKKCFAYCSIFPQDTEMEGDMLIELWMAEGFLHAGLENKTMEEIGEYYLEILLQSSLLEEIRYDEERYYKMHDMVHDVAKSIMSKSTKFINSETGSGDNSNQVRCLVIDSFGEGAKNLFESRSNLLHTLFLSQGSLSDDMLKKLKNLHVLNLSGEENQNLPISIGKLIHLRYINFEESTSETLPESICKLYNLQTLRLSYFLKVLPKGMSDLISLRHLHFYTSDEIFQMPLEMGRLTCLQTLEFFNVGREKGRRIEELGSLKNLKGKLEIHNLELVKDKEEAEVAKLSEKDNLFGLELKWAYNREGDDYNDEDVLDGLRLHPNLEELAIWYFMGNQFPRWLMDLPTTLPKLARLAFYHFNFTNLPGDLLHSCTSLQKLSVARCDNLISFPLDLQQTPSLLELHLYKCPKLKTSMTPKGFDFLTSLRELEIGPFSDDHENSSIYNEFDWSGLTSSSSSSSSSALRRLELYGLPHVESLPPQIQYLTALTSLLLHDFGGIKALPDWFGNFAALEGLYLYDFKELGRLPSEDAMRSLTKLKHLVVWSSPLLKGRCTPESSGPDSQWSKVSHIQDLRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VID1</accession>
    <name>A0A068VID1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_1146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00012391001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740230">
        <property type="protein sequence ID" value="CDP20367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VID1"/>
    <dbReference type="Gramene" id="CDP20367">
        <property type="protein sequence ID" value="CDP20367"/>
        <property type="gene ID" value="GSCOC_T00012391001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VID1"/>
    <dbReference type="OMA" id="DMVDEHN"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VID1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338:SF32">
        <property type="entry name" value="OS06G0287500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="177"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="416" mass="47009" checksum="26FD28F0D49C9C54" modified="2014-10-01" version="1">MTDPCVQFALAKLDAFLTGELRLPKEVDTGIRTLRSELGTITAFLSAAHQRAVQDQQILNWVRKVQDAAYDIIDILDLFDHHKAENGRALSVTRRRAYRSIADQINDIKSTLEEINKGRERYLPANSSHAALTPSPTTNRDYSDLHPRIVPLFLADADVVGFEEDKDMLMAWALDMVDEHNKVMFVVGMGGSGKTTLAKQVFEAVKQDFGCSAWISVSKSKKKLEILRNMLDQLCRCSSRAETAPTPQQQSSEHYINLIREYLLDKRYVIVLDDLWADDVWRSIMLALPRRNRSRIIITTRRGDIAYSLKDRSVAVHPIQQLSLEKAKELIHRIAFPGSRICPPALATLSNEILGKCEGLPLAITEIGHLLSTKGEREPEWKKLRDSLASELRSNGRLANIAKVLILSYDDLPYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJR6</accession>
    <name>A0A068VJR6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_2112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00009239001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741196">
        <property type="protein sequence ID" value="CDP20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJR6"/>
    <dbReference type="FunCoup" id="A0A068VJR6">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJR6"/>
    <dbReference type="Gramene" id="CDP20951">
        <property type="protein sequence ID" value="CDP20951"/>
        <property type="gene ID" value="GSCOC_T00009239001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJR6"/>
    <dbReference type="OMA" id="MGEDWAN"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJR6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000146">
        <property type="entry name" value="RING/FYVE/PHD zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022143">
        <property type="entry name" value="DUF3675"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033275">
        <property type="entry name" value="MARCH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012:SF215">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12428">
        <property type="entry name" value="DUF3675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
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            <begin position="212"/>
            <end position="237"/>
        </location>
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        </location>
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        </location>
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            <end position="299"/>
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            <end position="293"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="299" mass="32102" checksum="EDF877A565E82559" modified="2014-10-01" version="1">MGEDLIVKVDHVITPDALQSAPKSEGAGTSVERSSSHLVNPPASVIDIKEDEDDNVGEDEPLIQTVECRICQEEDSIKNLEVPCACSGSLKFAHRACVQRWCDEKGGITCEICHQPYQPNYTAPPPTLPEDTAIDIGEGWTIAGTPVDLNDPRLIAMATAERHLLEPEYDEYADSSASGAAFCRSAALILMALLLLRHALTIGNGDGDDDDVSTFFALFLLRVAGFLLPCYIMAWAISVLQRRRQRQEAAALAAAEVAFLLQAGQRRGIQVRIAPVPTPAPAPVAANEPAVTAHTGPAQ</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_3178</fullName>
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    </protein>
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        <name evidence="2" type="ORF">GSCOC_T00004165001</name>
    </gene>
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>Gentianales</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP21295"/>
        <property type="gene ID" value="GSCOC_T00004165001"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1751005at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKG4"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34836">
        <property type="entry name" value="OS06G0188250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34836:SF1">
        <property type="entry name" value="OS09G0428600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658751" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="98" mass="10453" checksum="8717D37A494274F6" modified="2014-10-01" version="1">MRRMDTLIGVLSIALLLCFQVCFAKEAAEHITIPVNVGVVLDAQTEIGKMGMKCISMALSDLYASHGSSYKTRLALNRRDSKRSVVGAAAAGSILSIP</sequence>
</entry>
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    <accession>A0A068VLC9</accession>
    <name>A0A068VLC9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_1268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00002534001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
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                <person name="Librado P."/>
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                <person name="Munoz A."/>
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                <person name="Perrotta G."/>
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                <person name="Rigoreau M."/>
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                <person name="Rozas J."/>
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                <person name="Zhang Q."/>
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                <person name="Bertrand B."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in environmental stress response.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068VLC9">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLC9"/>
    <dbReference type="Gramene" id="CDP20483">
        <property type="protein sequence ID" value="CDP20483"/>
        <property type="gene ID" value="GSCOC_T00002534001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLC9"/>
    <dbReference type="OMA" id="EVAPNQC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLC9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF67">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="168" mass="18083" checksum="FF90EEBAF25692F5" modified="2014-10-01" version="1">MAEEQKLQEPGSHRLCANNCGFFGSPTTLNLCSKCYKDHCLKEQQLKDAKLAVEKTLTPPETSSVSPLPSPDVKIDTIADPAELKAPAEDTVSTSAAPAAVAAAQPNRCASCRRRVGFTGFKCRCGITFCASHRYPEQHGCTVDYKAMGREAIAKANPVVKADKLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLI7</accession>
    <name>A0A068VLI7_COFCA</name>
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        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_4372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00002450001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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                <person name="Zhang Q."/>
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                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG745070">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068VPT0"/>
    <dbReference type="Gramene" id="CDP21718">
        <property type="protein sequence ID" value="CDP21718"/>
        <property type="gene ID" value="GSCOC_T00004201001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VPT0"/>
    <dbReference type="OMA" id="NITHSCH"/>
    <dbReference type="PhylomeDB" id="A0A068VPT0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
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    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP21718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="153" mass="17959" checksum="F809B0757D741C78" modified="2014-10-01" version="1">MIKLQPIMKSSQEFGFFQVIIHGAFEGLMEETMNVIQEFFRLPGFYSNDSGISQICRIFSSTLNYHKEDFHYWSDNITHSCHPVEDYIQSLPEKPTRYRTTIHTTFFEARKFLLRILDLICEGLGLIGYIEGELTKVQVFLDWECQNTMILIS</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Robusta coffee</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
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            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068TLR5"/>
    <dbReference type="Gramene" id="CDO97250">
        <property type="protein sequence ID" value="CDO97250"/>
        <property type="gene ID" value="GSCOC_T00014522001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLR5"/>
    <dbReference type="OMA" id="TPSMPYP"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044981">
        <property type="entry name" value="AGP9/17/18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37209:SF1">
        <property type="entry name" value="CLASSICAL ARABINOGALACTAN PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37209">
        <property type="entry name" value="LYSINE-RICH ARABINOGALACTAN PROTEIN 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654099" evidence="2">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="235" mass="22533" checksum="C91003D2C9D648F8" modified="2014-10-01" version="1">MEPRGVLLLGFICVIVAGVGGQAPPSPPTTTPSPPTPNAPTTAPPAPPTPTASPPPTTNPPPTPTSSPPPVPSSPPPVVSSPPPVVTSPPPVQASPPPASSPPPVSSPPPASPPPQVSSPPPVTPPPPAPASPPPSQPPPPPATPPPPASTPAPLAAPPASVPSPAPATPTSPAPSPLLRSPPSPPTAAPAPAPSLGTTAPAPSATDQSGAESIQSSAKIISSLAFGWAVLYFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMC5</accession>
    <name>A0A068TMC5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014852001</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDO97495">
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        <property type="gene ID" value="GSCOC_T00014852001"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="730111at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38530">
        <property type="entry name" value="OS06G0468300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="553" mass="60737" checksum="3EAF50D9929853B7" modified="2014-10-01" version="1">MPNSARPPPPLTSTHSPSQKRLLATQKPKHTPLPNTAPVHLPQNDKKTRDLPNLSDCHGCGLRIDYSNPKQRLQPLDSFWRIVLLCKKCIKQVTSGQICLYCFKDIANPSSDCFDCRDCDRLIHKDCVSKFGNSTPWSYCTRDLGFSVCIDCWVPELLKNSVRVRKKKNENGDSGSSGRAQNADRSLEETVKDAHCSVEKKVALAVKAKEKALRKAVVAKNAVELANNALDLAVKKDGIGKTISEGLLADDAELAFRLHRAMNSSPRISKHTCSVNLSCSDILKKNGLNGISPNWMDSGSCEGGKAGGCTNSKLDAVHERSISETSAYVESKEGGSVLASGSLKPVLKTYSRNNLKRNECFRNGEAGDTMSVGVVKPILKTYRRNNLKRRECLENGEIGDAVTSAVVKPVLRTYTRNIFKRKDCLGNGKVGDLGTCTIKDDTRIVSESQCCLQDEVKMELPVDSAWNFSPEQSSGDIIQQEGSANAKPEECLLEYNKRIRGSSQGLQTDASSYCIAFNKENQASAPRLAYCSAECSGFWFISRRDLNCTGILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNF8</accession>
    <name>A0A068TNF8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNF8"/>
    <dbReference type="STRING" id="49390.A0A068TNF8"/>
    <dbReference type="Gramene" id="CDO96898">
        <property type="protein sequence ID" value="CDO96898"/>
        <property type="gene ID" value="GSCOC_T00014076001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNF8"/>
    <dbReference type="PhylomeDB" id="A0A068TNF8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO96898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="191" mass="21686" checksum="E70534F34B8D97FC" modified="2014-10-01" version="1">MAWNEEVSMDCFLILRVLVYPACKCPEASTILQSLGGVKDFFKSTGSPFLAAPWPIMRVHLMDMNFFPPNFGCDILKAKWIRSYASPTDYRMHAVTGNSAITEVIQAYVAAFHTRKLELPEDSSTLYKMSLDNEAAIQAEFLPHNADFKFLDKAAIQKFTTESEKPNPWKLCRVTHVENAKILLKMLPIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPC8</accession>
    <name>A0A068TPC8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00014444001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPC8"/>
    <dbReference type="FunCoup" id="A0A068TPC8">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPC8"/>
    <dbReference type="Gramene" id="CDO97183">
        <property type="protein sequence ID" value="CDO97183"/>
        <property type="gene ID" value="GSCOC_T00014444001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPC8"/>
    <dbReference type="OMA" id="QKQTGRM"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000015">
        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF7">
        <property type="entry name" value="PROTEIN DJ-1 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="4">
        <location>
            <begin position="82"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="4">
        <location>
            <begin position="285"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO97183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="467" mass="49987" checksum="98608EEB6A25D9B2" modified="2014-10-01" version="1">MRTSITPLYFIPTTLPKSDHHCLASLSTRSFRALGFRVFAAAVSEQRKTPSISKPPKTPFPSPTASIPTPSPAANENPPKTKKVLVPIGFGSEEMEAVILVDVLRRAGAEVTLASVEQRLEVEFSGGTRLVAAAFVSACSDQIFDLIALPGGMPGSARLRDCEILQKMTSKQAEEKRLYGAICAAPAVTLLPWGLLRKKKTTCHPAFIDKLPTFWAVKSNNQVSGELTTSRGPGTSFEFAISLVSQLYGETAAKEIKDSLLVNDSGSHKKEEFNEVHWSLDHTPQVLLPVANGCEGIDIVTTIDILRRAKASVVVASVEKSTQILASQGIILVADKLINAAAEITYDLIILPGGVGGAERLHKSRVLRKLLKEQQIGGRIFGAMCSSSAILQRQGLLKDKKATAPESVLSKESNVVDGAQVVIDGKVIANKGLASATDFGLAIVGKLFGHSRARSVAEGLVFEYPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPG5</accession>
    <name>A0A068TPG5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021750001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPG5"/>
    <dbReference type="STRING" id="49390.A0A068TPG5"/>
    <dbReference type="Gramene" id="CDO97834">
        <property type="protein sequence ID" value="CDO97834"/>
        <property type="gene ID" value="GSCOC_T00021750001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPG5"/>
    <dbReference type="OMA" id="ACFECIS"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPG5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46503:SF9">
        <property type="entry name" value="INTER ALPHA-TRYPSIN INHIBITOR, HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46503">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="323"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="736" mass="81630" checksum="629532CC5752CADF" modified="2014-10-01" version="1">MADQFSKSVEFGLKLSKRIFYGKESSAPAPAVMERKSETNWPLLPTGPMVYAVISEPSMVDNPDIPSYQPYVHGRCEPPALIPLHMHGVAMEVDCYLDTAFITVTGTWRLHCVTASKSCDCRIAVPMGEKGSILGVQVECPLRSYSTQLTTLEEDREADKAKDGFLLKGHIYTLKIPQVDGGCTLSVRISWSQKLLCQNNQLCLKIPFTFPQYVTPVGKKVSKIEKILLNVNSGIAVEIFCKSSSHPLKQVSRQAGKLQFSYEREASMWSINDFSFIYSVSSNDIVGGVLLQSPPLHDFDQRDMFCFYLYPGNTNNRKVFRKEVIFVVDISASMRGDPLDKVKAAVLTALSKLNPADSFNIIAFNGLSLLFSSSMELATKEVIENASQWIANNVVADGSTNISLPLSQALKMVSKAGDLISLIFLITDGSVEDERDICAIVKHQAMEGGFNSPRINTLAIGSYCNHYFLQVLAEIGRGYYDAAYDMDSIDFRLERLFDQASSVILADLTIDCLEQLDSLELYPFQLPDLLSESPLLVSGRYTGKFPDSVKFRGTLADLENYVIDAKVQKAKDFPMERMCARSQIDALTANAWLSEDKQLEEKVERMSLQTGVPSEYTNLVLLETKKEKQISESSGKKVIVLRRVGAGFGSLKATAENLPPETAEPKLHETSEMITKAARNLCGRMLDCCCCMCFIQFCSRLNDQCAVVLTQLCTALACFGCMNFCCEVCFSCDFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ37</accession>
    <name>A0A068TQ37_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GSCOC_T00014830001</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ37"/>
    <dbReference type="FunCoup" id="A0A068TQ37">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ37"/>
    <dbReference type="Gramene" id="CDO97478">
        <property type="protein sequence ID" value="CDO97478"/>
        <property type="gene ID" value="GSCOC_T00014830001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ37"/>
    <dbReference type="OMA" id="HHPNTDW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ37"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000024">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000016">
        <property type="entry name" value="Somatic embryogenesis receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 24" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656956" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="30"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="293"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDO97478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="617" mass="68471" checksum="C10513E16B5845B5" modified="2014-10-01" version="1">MDRSVVSAISASAFISFLLLFLRFLRVSGNAEGDALNALKTNLADPNNVLQSWDPTLVNPCTWFHVTCNSDNSVTRVDLGNANLSGQLVPQLGLLPNLQYLELYSNNISGRIPNELGNLTNLVSLDLYLNSLNGPIPDTLGKLQKLRFLRLNNNTLTGHIPMTLTTVQTLQVLDLSNNQLTGQIPVNGSFTLFTPISFQNNHLDPLPVSPPPPISPTPPSARGTNSATGAIAGGVAAGAALLFAAPAILLAWWRRRKPQDHFFDVPAEEDPEVHLGQLKRFSLRELQVATDSFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMVNGSVASCLRERPESEPPLDWPIRKRISLGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLREKKLETLVDADLQGNYVEDEVEQLIQVALLCTQSSPTERPKMSEVVRMLEGDGLAERWEEWQKEEMFRQDFNHTHHPNTDWIIADSTSNLRPDELSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQE3</accession>
    <name>A0A068TQE3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022232001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">cv. DH200-94</strain>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO98212.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="167" mass="18342" checksum="DC7922020A8EE8A0" modified="2014-10-01" version="1">MVRLDFHLVQLFFACLPSLAVYFVAQYARSEMRRMDAELEVKKKAEEEAKATEKAAEEQEMTSDPQLLAVKVRLDKLEETVKEIVVESKKKSADPRDKGQVDDGGRKQPTMVKPNNSAGDASSFNAAKGSPSKEAGEGRTPSTALTDASQGDQKSSKNYEPSSDVKK</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="9">Cleavage stimulation factor subunit 2 hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
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            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="EnsemblPlants"/>
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    </dbReference>
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        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Cleavage stimulation factor subunit 2 hinge" evidence="6">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription termination and cleavage factor C-terminal" evidence="5">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="99"/>
        </location>
    </feature>
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            <end position="131"/>
        </location>
    </feature>
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        </location>
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            <end position="225"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="41818" checksum="3C461A8F7C0897D5" modified="2014-10-01" version="1">MAGKQVPGEGISANLAGMSKNQLYDIMSQMKQLIEQNQQQARQILIQNPVLTRALFQAQIMLGMVQPPQAIPNVQPAASQNPQPSKSPIQQSNIQTSSPVPGPTIKQEPNIKQEQNLPATTVSSASALPSNLQPPSFPSHPSQSTQQPKGHIATQPTQMPIRQSSQLPNMPHLPHHAAAQPPSHLQAPIPSASNQLQQPMQTTSVSHLPPLQPPLPTQQRPPVPGFPHQGQSQMGLNVGFQHSSAPQLHPSQPVYHSGTRPPAGPGHSFLQGQPPHPIQAPLQPPYQVGGSQLGTDFNQIASSNQADRGSPWIPGMKQESASAAQLSGQPQFPGQMGTGNQQPRPPSLTPEMEKALLQQVMSLTPEQINQLPPEQRNQVLQLQQMLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRF1</accession>
    <name>A0A068TRF1_COFCA</name>
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        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRF1"/>
    <dbReference type="MEROPS" id="M20.014"/>
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        <property type="gene ID" value="GSCOC_T00021897001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRF1"/>
    <dbReference type="OMA" id="THLWATE"/>
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        <property type="component" value="Chromosome VI"/>
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        <property type="term" value="F:IAA-Ala conjugate hydrolase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidohydrolase"/>
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        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
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        <property type="entry name" value="ILR1-like_Hyd"/>
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        <property type="entry name" value="Peptidase_M20"/>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 5" id="KW-0464">Manganese</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="167"/>
            <end position="261"/>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
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        <ligand>
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            <label>2</label>
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            <position position="89"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO97948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="394" mass="42760" checksum="0FAF84C35D169CE8" modified="2014-10-01" version="1">MVGIRRKIHENPELGYEEFETSKLVREELDKMGIPYKYPVAVTGVVGFVGSGEPPFVALRADMDALAMQEMLEWEHKSKNPGKMHACGHDAHVAMLLGAAKILQEHRKILKGTVVLVFQPAEEGGGGAKKMIDAGVIENVKAIFGLHVKPDLPVGEVESRPGPLLAGSGFFEAVISGKGGHAAIPQHSIDPIVAASNVIVSLQHLVSREADPLDSQVVTVGKFQGGGAFNVIPDSVTIGGTFRAFSKESLMQLRQRIEEVIVGQAAVQRCNATVNFLSTEKPFFPPTVNNKDLHNHFLKVASDMVGTANVKEMQPLMGSEDFSFFQEVIPGYFIFIGVKDEKNTKPASVHSPFFKINEDALPLGAALHASLAIRFLLESNAETPLLNQKLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSI6</accession>
    <name>A0A068TSI6_COFCA</name>
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        <recommendedName>
            <fullName evidence="13">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00026318001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome V"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Brevis_radix_dom"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="RCC1-like_dom"/>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="Ub_ligase/GEF_domain"/>
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        <property type="entry name" value="Znf_FYVE"/>
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    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF352">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION (RCC1) FAMILY PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCCNDNSATION"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
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    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <begin position="228"/>
            <end position="286"/>
        </location>
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    <feature type="repeat" description="RCC1" evidence="6">
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            <begin position="287"/>
            <end position="338"/>
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    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="339"/>
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            <end position="445"/>
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    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="456"/>
            <end position="507"/>
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    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="508"/>
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    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="560"/>
            <end position="611"/>
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    </feature>
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        <location>
            <begin position="616"/>
            <end position="678"/>
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    </feature>
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        <location>
            <begin position="1018"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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    </feature>
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            <begin position="775"/>
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        <location>
            <begin position="931"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1071"/>
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        </location>
    </feature>
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        <location>
            <begin position="815"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO99240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120369" checksum="625C5B5653956EB2" modified="2014-10-01" version="1">MADPVSYGNPDRDIEQALIALKKGTQLIKYSRKGKPKFCPFRVSPDETTLIWYSHGSERILKLSTVQRIIPGQRTPVFRRFLRPEKEYLSFSLIYNNGERSLDLICKDKAEAEVWIAGLKALTSTSHARGRRTRSDIPDLHEAGSDPIPNGRPFGTTLEFTTSIPRGRASVDLVSREPSLNFPGSDVGSESANMQGRSSGGDGFRISVSSTPSCSSGGSGQDDIESLGDVYVWGEIWSDGVSTDRYGNPVPIKNDVLTPKSLESSVVLDVQQIACGHRHVALVTRQGEVFTWGEESGGRLGHGIEKDFSRPRLVEYLAVTNVDFVACGEHHTCAVSTSGDLYSWGDGTHNAGLLGHGNDISHWIPTRISGPLEGLQVLSVACGIWHSALATSNGKLFTFGDGSFGVLGHGDRKSVTCPKEVQLLSGLKTIKVACGAWHTAAIVEVTNQSGTTVSSKKLFTWGDGDKYRLGHGNKETYLLPTCVSALIDYNFHQIACGNNTTIALTTSGHVFTMGSNACGQLGNPQSDGKSPCLVQDRLVGEFVEEIASGAFHVAVLTSRSEVFTWGKGANGRLGHGDIEDRDVPTFVEALKDRHVKNIACGSNYTASICIHKWVSGADQSLCSGCRQAFGFTRKRHNCYNCGLVHCHACSSKKAMKAALAPTPGKPHRVCDACYMKLKKAAEANNSSTFGRNATASHRPVESSARLDRREPRTSRILLSPTMEPVKYLEVRSGKLGTQPDYSIIRESQVPSLLQLKDIAFPSSLSALQYALKPVTTAPQTPPPSQPASNSRPASPYSRRPSPPRSVTPVFSRGVIDGLKKTNEFLNQEVSKLQKQIKSLKEESQLQEQEVQKLKNKAQEAASLAVERSSKCTVAVKTMKLIANQGRLEGRHPAGRVLKEVTERLPSDILEMETFTSIHFQVESFLEMIGPHEPDEESSLQPHTVHDQHSQPDQTLSANESAERPDRSMEDNVHSPGLQDMQQNAEATPRERRPSISHIREGSVQASAEGGLGSPKAAREVIEQFEPGVYVTLIQLSNGTKIFKRVKFSKRRFMEQQAEEWWKTNKDRLLRKYSTPKVNSTSPESSGTPEASEEKSEAAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUU5</accession>
    <name>A0A068TUU5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00029495001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUU5"/>
    <dbReference type="Gramene" id="CDO99802">
        <property type="protein sequence ID" value="CDO99802"/>
        <property type="gene ID" value="GSCOC_T00029495001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUU5"/>
    <dbReference type="OMA" id="AMKISTH"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF110">
        <property type="entry name" value="PROTEIN NUCLEAR FUSION DEFECTIVE 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="8">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="9">
        <location>
            <begin position="357"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO99802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="596" mass="65585" checksum="9FC8C712A5135190" modified="2014-10-01" version="1">MAETTVLTSSHGCGLCGFMVQFLRGRWFMMFATFLIMSGSGATYIFGAYSKAIKSSLGYDQSTLNILGSCKDLGATIGVLSGLLAEVTPSWFVLLVGALMNFSGYFLVWLAVTKRIPKPPVWQMCVYICIGANSQNFANTGSLVPCVKNFPERRGMMLGLMKGFVGLSGAIFTQLYLAIYHNDAKDMILLIGWLPAVISLVFLFCIKEMKKISGHPHEVKVMYQNLIITVGLALTLMALTIAQNYFNFSHADYVASATGVCVLLFLPFLVAVKEELETWQQKKEDALKPPNRVVTEEPPLPESSNPRKQEIVPAHCTIDKGGGDDEFRQEGCCCGDICNKPKRGEDYTICQALLSADMIILFIVTFCGLGCSQAAVDNLGQIGESLGYPTKTVNTFVSLLSIWNYFGRALSGFGSEQLLRKWKVPRTLMMTISLVVPAIGDLIIALPFPGSVYIASVLVGFAYGVQLTMVFVIISELFGLKYYSTLLNCGQLASPIGSYFLNVRIVGKLYDKEALKQLARAGLTRSMVPDLTCIGTQCYRTSFLILAGVNTLGALISLILVMRTREYYKSNIYMKFRDEMEANEKEIAMVSSADHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY31</accession>
    <name>A0A068TY31_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00032942001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY31"/>
    <dbReference type="SMR" id="A0A068TY31"/>
    <dbReference type="Gramene" id="CDP00839">
        <property type="protein sequence ID" value="CDP00839"/>
        <property type="gene ID" value="GSCOC_T00032942001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY31"/>
    <dbReference type="PhylomeDB" id="A0A068TY31"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000317">
        <property type="entry name" value="Inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF73">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657418" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="800"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121046" checksum="4E7B4C1D40EDDE7D" modified="2014-10-01" version="1">MDAANFLLLSALLVMHFATIAGGFGVVTTKNNTRDLDALLALKATILDPQNIIPTNWSSSSSLCNWIGITCNTRHQRVAAIVLPHMGLLGTIPPELGNLSFLVRLNFVNNSLHGHLPTELSHLRRLKYIDLEGNAFDGGFPSWLATLPELRVLNFLYNNFSGSLMSCGISNVTKLETLNLGHNSFTGNIPDEFSGLKNLSIVNIGHNQLTGSLPPSLFNLSSLEILSLTNNSLSGSLPEHICNHLPQLQGLYLSINQLEGEIPSGIGKCSRIQQFSFSTNKFTGSIPREFWNLSMLQTVYLGKNHLKGTIPQAIGYLNKLEDLALDSNRFTGPIPAKLFNISSLQTISLAANDLSGGLPTTLGIMLPSLEYLFVGGNRLSGVLVLTSISNASSLIGLDVSFNQFTGAIPHSLGDLRLLEVLDLKSNSFSYKSNSGEISLLISLSNCRYLQELELDESPLNGFLPTSIGNLSNNLRLLSLNYCGIFGQIPSSIENLTNLADLSLGGNALEGINPASIRRLSELQKVELGYNRIQGPFPSELCDLVNLGRLSLSSNMVSGRLPSCIGNITSLRYLYLDSNNLTSKLPSNLWSLSDILELNLSTNTFQGSFPPELQNLKALTIMDLSVNDFYGDIPSTIGALQMLQELSLKHNRLQGPIPDSMKNMLELQYLDLSFNNLTGAIPKSLELLQNLVHFNVSFNKLRGPVPHGGPFANLTELSFLSNEALCDAPWLQPCQTFEHRSRKKTLLFVLLAVGSAMFAMVISILVIRKWRRKFVIPTNFVVEATVERVSFHELRQMTNGFHEDMLLGSGAFGSVYKGVRENGMTWAIKTFDLQLEGAFKSFDTECEVLRSVRHRNLTKVISACSSPDFKALVLEYMPNGSLEKWLYSGSQILNIKQRLDIMIDVACGLEYLHYGYSTPVVHCDLKPSNILLNQDMVGHVCDFGITKLLGDGENVIQTKTLATFGYIAPEYGLEGLVSTSCDVYSFGITLMETFTKRRPKDEMFTEELSLRRWIEESVPDFAIKVMDADLLHLEDELVKSKLACISSILQLGLYCTTYSPEDRMNMKDVLRGLQKIKLQFFEEPKPLKQVHNHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY93</accession>
    <name>A0A068TY93_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">GSCOC_T00034753001</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068TY93">
        <property type="interactions" value="1882"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TY93"/>
    <dbReference type="Gramene" id="CDP01191">
        <property type="protein sequence ID" value="CDP01191"/>
        <property type="gene ID" value="GSCOC_T00034753001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY93"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY93"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000043">
        <property type="entry name" value="acetyl-CoA carboxylase 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="25">
        <location>
            <begin position="47"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="24">
        <location>
            <begin position="200"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="23">
        <location>
            <begin position="685"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="26">
        <location>
            <begin position="1509"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="27">
        <location>
            <begin position="1852"/>
            <end position="2164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CDP01191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2274" mass="253983" checksum="C8DAAE5786187F37" modified="2014-10-01" version="1">MSEAQRQPLVGGTNRSNGYMNGAISFRSPSTVSIVDEFCRALSGKRPIHSILIANNGMAAVKFIRSIRTWAYETFGTEKAILLVAMATPEDMKINAEHIRIADQFVEVPGGTNNNNYANVQLIVEMAEITHVDAVWPGWGHASESPELPDALGAKGIIFLGPPATSMGALGDKIGSSLIAQAAEVPTLPWSGSHVKIPPESCLVSIPEDIYSEACVYTTEEAIASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVKALFKQVQGEVPGSPIFIMKVASQSRHLEVQLLCDQYGNVAALHSRDCSVQRRHQKIIEEGPITVAPLETVKKLEQAARRLAKCVNYVGAATVEYLYSMETGEYYFLELNPRLQVEHPVTEWIAEVNLPAAQVAVGMGIPLWQIPEIRRFYGMEHGAGYDAWRRTSVVATPFDFDQALSTRPKGHCIAVRVTSEDPDDGFKPTSGKVQELSFKSKPNVWAYFSVKSGGGIHEFSDSQFGHVFAFGESRALAIANMVLGLKEIQIRGEIRTNVDYTVDLLHASDYRENRIHTGWLDSRIAMRVRAERPPWYLSVVGGALYKASASSAAVVSEYIGYLEKGQIPPKHISLVNSQVSLNIEGSKYMISMVRGGPGSYKLRMNESEIEAEIHTLRDGGLLMQARILLDGNSHVIYAEEEAAGTRLLIDGRTCLLQNDHDPSKLVAETPCKLLRYLVADGSRVDADTPYAEVEVMKMCMPLLSPASGIIHFKMSDGQAMQAGELIARLDLDDPSAVRKAEPFHGSFPVLGPPTAISGKVHQRCAASLNAARMILAGYEHNFGEVVQNLLSCLDNPELPFLQWQECFAVLANRLPKELRHELEAKYKEHEGISNLQNVDFPAKILRGVIEAHQMSCPDKEKGAQDRLVEPLLILVKSYEGGRESHARVIVQSLFEEYLSVEELFSDNIQADVIERLRLQHKKDLLKVVDIVLSHQGIKSKNKLILRLMEQLVYPNPAAYRDKLIRFSTLNHTNYSELALKASQLLEQTKLSELRSNIARSLSELEMFTEDGENMDTPKRKSAINERMEALVSAPLAVEDALVGLFDHSDHTLQRRVVETYVRRLYQPYLVKGSVRMQWHRSGLIASWEFLEEHIERKNWYQDQTLEKPLLEKHSDRKWGAMVIIKSFQLLPTILTAALRETTHSPQTTTSKGSILPASHGNMMHIALVGINNQMSMLQDSGDEDQAQERINKLAKKLREQEVSFSLRSAGVGVISCIIQRDEGRGPMRHSFHWSAEKQYYEEEPLLRHLEPPLSTYLELDKLKGYDKIQYTPSRDRQWHLYTVVDKPVPVQRMYLRTLVRQPTSSDSLTVYQGLDKERSQSLWAISFTSRSILRSLVSAMEELELHVHNTTVKSDHAHMYLYILQEQQIDDLLPYDKRVDINDGCEEAIVEKILQELAHEINTSIGVRMHRLGVCQWEVKLWISSEGEANGAWRVVVANVTGHTCIVHVYREVEDPTEHKVVYHTITERGPLHGVPVNASYQPLGVLDRKRLLARKSNTTYCYDFPLAFKAALEMAWSCQHLGHKRPEDKVILEVTELIFANTGGNWGTPLVSVERQPGLNDVGMVAWSMKMSTPEFPSGRTILVIANDVTFKNGSFGPREDAFFQAVTEVACSLKLPLIYLAANSGARIGVAEEVKSCFRVGWSDESIPERGFQYVYLTPEDYARIGSSVIAHETKMTNGESRWVIDSIVGKEDGLGVENLSGSGAIASAYSRAYKETFTLTYVTGRTVGIGAYLARLGMRCIQRLDQPIILTGFSALNKLLGREVYSSHMQLGGPKIMATNGVVHLTVSDDLEGVSAVLKWLSFIPPYSGGPLPLLPPLDPPERPVEYLPDNSCDPRAAICGASDGSGNWLGGIFDRDSFVETLEGWARTVVTGRAKLGGIPVGIVAVETQTMMQVIPADPGQLDSHERIVPQAGQVWFPDSATKTAQALIDFNREELPLFILANWRGFSGGQRDLFEGILQAGSNIVENLRTYKQPVFIYIPMMGELRGGAWVVVDSKINPDHIEMYAERTAKGNVLEPEGLIEIKFRTKELLECMGRLDQQLIGLKAKLQEVKSTEAVDGLQQQIKAREKQLLPVYTQIATKFAELHDTSFRMAAKGVVRKVVDWADSRFFFYRRLYRRVVEDSLIRTVRDAAGDLLTYNSAMDMVKKWFMDSEFSGGKPDAWMNDEAFFSWKDDFSNYEEKLQELRVQKVLLQLTKIGDSALDLRALPQGLFALLQKVEPSAREQLVGELRAVFDRSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZD4</accession>
    <name>A0A068TZD4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036773001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZD4"/>
    <dbReference type="STRING" id="49390.A0A068TZD4"/>
    <dbReference type="Gramene" id="CDP01655">
        <property type="protein sequence ID" value="CDP01655"/>
        <property type="gene ID" value="GSCOC_T00036773001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZD4"/>
    <dbReference type="OrthoDB" id="1695800at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZD4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="67" mass="7799" checksum="D32011847F6AC4CE" modified="2014-10-01" version="1">MWRSVNELMLVRWDQTKPASVSNLVLLKFSEADEHESRSLEDIQKEEPEFFARVTSVLKQAESDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZD9</accession>
    <name>A0A068TZD9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00032721001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZD9"/>
    <dbReference type="Gramene" id="CDP00688">
        <property type="protein sequence ID" value="CDP00688"/>
        <property type="gene ID" value="GSCOC_T00032721001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZD9"/>
    <dbReference type="PhylomeDB" id="A0A068TZD9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="318"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="590" mass="66126" checksum="266DE04831A56BD8" modified="2014-10-01" version="1">MAYAAAASLVQTLEYLLQFPCLVLEMKKMQAEVVTQRFRQVLLLLKGEPSASSSSGLQQLSEEPETLASSFEGFLGAVGPHADFLEIKKRTVSLSCGIPKLQEKKPPILTKIGSLEQDLKKFLETTVLDIRTDLPNYVVHQPSREAARKMLRAVDKLKQAIIFFYEVASEITILYQDLFSLLSFLDDSSDKFQDHELLKCIKDVAYRARDLVEECILDNQVESVKTYLICTLSNSESPSRFLHQAVGKSSLETVVKSALDGKKGIRRGLVHALQDVQSIKRMTTNIDEKSLRLQGSSVRKAPLSSNKEDIVVGLDAELTTILEGLTGLPGLEIVTISGMGGIGKTTLARKAFNDPYIVYHFYCRAWITVSQVYQVRDLLLGLLSSIARSTDKMVEKSNAQLAEAVYRSLKGMRYMIVMDDMWSIDAWNDVKRCFPDDKNGSRIVVTTRFMELATNVSPKKPPHCMNLLSAEQRWELLEMLIFGTASCPQELVGVGKKIAKRCRGLPLAIVVVAGVLSRVIREYNYWNNIAEEVSSVVSTDPENCLDILALSYNYLPHHLKACFLYMRIFPEDCKLEVSKLINLWAAEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZQ0</accession>
    <name>A0A068TZQ0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032948001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZQ0"/>
    <dbReference type="Gramene" id="CDP00843">
        <property type="protein sequence ID" value="CDP00843"/>
        <property type="gene ID" value="GSCOC_T00032948001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZQ0"/>
    <dbReference type="PhylomeDB" id="A0A068TZQ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="6723" checksum="B5CFDCBC59C0C088" modified="2014-10-01" version="1">MALEWIVLGYVAAAEAAVMVLLLTILSADHLTWPSNIHNKEPPRVISDDGLVCSFLLLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZT1</accession>
    <name>A0A068TZT1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00036501001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZT1"/>
    <dbReference type="STRING" id="49390.A0A068TZT1"/>
    <dbReference type="Gramene" id="CDP01449">
        <property type="protein sequence ID" value="CDP01449"/>
        <property type="gene ID" value="GSCOC_T00036501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZT1"/>
    <dbReference type="OMA" id="LGWSVWP"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZT1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000096">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000086">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF12">
        <property type="entry name" value="AMINOTRANSFERASE, CLASSES I AND II FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="30"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP01449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="398" mass="44222" checksum="FE885E91F48B442E" modified="2014-10-01" version="1">MEEKLSAVTKTITPSPIQQLSLLAQRCNAINLSQGFPDFPAPPHIKEAAICAINSDFNQYRHVQGICEYVACKMKQTQGLDVDPLTDIVICCGQSEAFAATMFAIIDQGDEVILFDPSYETYDTCIRLAGGVPVYVPLDPPCWKLDPEKFIKSFTAKTKALVVNSPHNPTGKVFTKDDLEIIAGACRTWDILAVTDEVYEHITFDNEKHISLASLPEMQKRTIVTSSLSKTFSVTGWRIGWAIAPARIALAIRNIHVKVTDCAPAPFQEAALAALRSSPEYFDSLRRDYQSRRDFIHELLVKVGFPMQFRPMGSVFVFAELPESCTLSDVEFVEQLIKQAGVVAVPGSGFFHKSSCSSTFSYQSRYIRFAFCKSFDTLNIAAQKITGLVTETGRLELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0P4</accession>
    <name>A0A068U0P4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00036847001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0P4"/>
    <dbReference type="STRING" id="49390.A0A068U0P4"/>
    <dbReference type="Gramene" id="CDP01709">
        <property type="protein sequence ID" value="CDP01709"/>
        <property type="gene ID" value="GSCOC_T00036847001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0P4"/>
    <dbReference type="OMA" id="FTEHEHE"/>
    <dbReference type="OrthoDB" id="1704684at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0P4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP01709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="178" mass="20911" checksum="F903372CC283EB3E" modified="2014-10-01" version="1">MLSFAFGVIPVSKKNKKKGFKEELEERLISLIASLFGGILRGSRRERLLIKFVEHECEKIDRLMELYMRYSNRVKAETERLNDIELDDLEMDEEEKYNRKLDSGLYTLQLIAVILGHLWTSEHPQMRARIELLLKQNKLSRKDVKDVLQEYHGNVGDLEGPEEKERAQSKIQKFISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0W7</accession>
    <name>A0A068U0W7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037176001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
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            <strain evidence="4">cv. DH200-94</strain>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="229" mass="26264" checksum="1EA90364B9638A83" modified="2014-10-01" version="1">MDPNAVKSTLSNLAFGNVMVAAARDYQKELMAQEKAQASATANEEVDLDELMDDPELERLHADRIAALKKEAEKRQELKRQGHGEYREITEGDFLAEVTGTEKVICHFYHREFYRCKIMDKHLKSLAPRHLETKFVKLDAENAPFFVAKLAIKTLPCVIFFRNGIAIDRLVGFQDLGGKDDFTTKALEILLLRKEMIKENKLEEEEDDDYHENRQRTVRSSVNADSDSD</sequence>
</entry>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN ZAT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47591:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN ZAT2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
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            <end position="136"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="362" mass="39284" checksum="628CFFF74B8891EE" modified="2014-10-01" version="1">MENDQSNIDDKGTTFVVDASTSDSPTPLMTCPDGQEISPPTPTPPFLDSAPGTSGTKNVTFPSLKYHQKPRKKRTKLVNIAEHGVKSGGNISKPKCARKPDPNAPKITRPCTECGKKFWSWKALFGHMRCHPEREWRGINPPPNFSRHHHNDALTSGTKENSYWMSEEDHEVAVYLLMLANGRTSESDNAAALMGCGDVDENTAAAGPSSGLLNCTRFECSSCKKVFGSHQALGGHRASHKNVKGCFAITKNDGEEEDRTGEGEVVKDGTVEEDKMLMVFGHKCTICLRVFSSGQALGGHKRCHWEKGDEPSGFTQDLNPFSSGKEGSSGLDLNLPAPAEDDDSSSSYYSGLALDLRLGLKP</sequence>
</entry>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="De Bellis F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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            <end position="244"/>
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            <taxon>Gentianales</taxon>
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            <taxon>Coffea</taxon>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
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                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">cv. DH200-94</strain>
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            <end position="1640"/>
        </location>
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        <location>
            <begin position="2610"/>
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        </location>
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        <location>
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            <end position="1511"/>
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        </location>
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        <location>
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            <end position="3177"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="4576"/>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1535"/>
            <end position="1545"/>
        </location>
    </feature>
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        <location>
            <begin position="3167"/>
            <end position="3177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
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            <end position="4972"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="5110" mass="567446" checksum="D4D68B38FCFD9745" modified="2014-10-01" version="1">[encoded data, 5110 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3N6</accession>
    <name>A0A068U3N6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00040262001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3N6"/>
    <dbReference type="FunCoup" id="A0A068U3N6">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3N6"/>
    <dbReference type="Gramene" id="CDP02769">
        <property type="protein sequence ID" value="CDP02769"/>
        <property type="gene ID" value="GSCOC_T00040262001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3N6"/>
    <dbReference type="OMA" id="SATCMNN"/>
    <dbReference type="OrthoDB" id="1928505at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3N6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032795">
        <property type="entry name" value="DUF3741-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21726:SF61">
        <property type="entry name" value="DNAA INITIATOR-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21726">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P DOWN SYNDROME CRITICAL REGION PROTEIN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14383">
        <property type="entry name" value="VARLMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4378" evidence="2">
        <location>
            <begin position="824"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="107520" checksum="4774A08B9BDC875E" modified="2014-10-01" version="1">MSEISGQTTLAIVEKRPQRPGGCAGILFQVFDWNRKFAKKKLFSKKLLPPVRLRKSSKKFGVDEKLPKLRLIADENSGGFPYMKKNEGCCNGDTAQKNEMRAPGLVARLMGLESMPDVKQDKSKKTLLSGSGSDKEEYVHSHGRFEREELIAEKGETKQEFRPQKLQKTGLSERKPVTKFGAEALQIKHMLSRSRKHHQKLVSPVKSPRNVSGRNASRFIGAATRILEPGLQRSKSKCALAYSNAIDHPPTADAFLVEANDVESFQDARCFQTSAKPLNGQSSSCTNCGHSLGGMSTAEQQPALSSGSQFVHPPCQMSERESGRLAIFCPELEKGKTEEGSLLYAAAAMEGRQPCANYMPEIKLLKKAGQRLWQAASPQGKLQKDVSPACLRHKMQGQDQMFQVRNRLPSRSKLIRVQSNRVSAAANATNETTNLVLQKQNISNHSHLRMSPKQDIYRLDTDQRFGDRGHDSLSPLQKRRSLNSSRQNEGSRFVSSTLVKPTNIRSSAISGKGRSSTSHSTIGPCTSIRLAHLQGSINADSSQNDSDVISFTFKSPMKRKTGIHADMEGKRNQSGPNSEVTLRKLSLNENEGKRNSLKSFPLSGDSLGVLLEQKLKELTCQEEDSAFGDTAPRKTTAVILQELISALTTERPSHWDQLVYGVNNRDSYLRSDNQQLDDKTFAAFQAKPKSTKISVGYLPNGEHLSPGSVLDASFSNDSFASSSLDDGSRCNLGMESTEYYEGQRQLETDADLLDSACSLSIGKFYRESVTNLLNNISVVFSAINLADGHLKGRKLTHAKEVILNAELVFVNAALPDAVVNGGFSISHFVLNELELLASVMRTNFSGFVAFDINNKEGNQLKGFVFDCVIEYLESRFARYSNSGFNAWTRLPLRMKTEMLICEIVEEVGRWAGLAGLMVDELIEHEMSRSFGKWTDFELEAFETGTEIDQQILQSLITEVAVDFMCSSASEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3X3</accession>
    <name>A0A068U3X3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00041275001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3X3"/>
    <dbReference type="FunCoup" id="A0A068U3X3">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3X3"/>
    <dbReference type="Gramene" id="CDP02874">
        <property type="protein sequence ID" value="CDP02874"/>
        <property type="gene ID" value="GSCOC_T00041275001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3X3"/>
    <dbReference type="OMA" id="KQEEGMI"/>
    <dbReference type="OrthoDB" id="749055at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3X3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000021">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000016">
        <property type="entry name" value="Somatic embryogenesis receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657584" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="27"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="300"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP02874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="641" mass="70177" checksum="7C0F7C4BB4B82362" modified="2014-10-01" version="1">MAMSVIFSYRFFLLGFFVFSPTLCYSYEARNPEVEALISVKNALSDPHGVLSNWDEDSVDPCSWSMITCSSDNLVTGIGAPSQGLSGTLSEVIANLTNLKQVLLQNNNISGHIPLELGNLSNLETLDLSSNKLSGPLPDSLGFLTKLQYLRLNNNSLSGAIPPSLAKVPQLAFLDLSYNNLSGPVPRFPTKAFNIVGNPLICGSHSGKSCSGHFNMSSLSFSMDSSPGKSNSKRLAVALGVSLSFVSIFLLAIVVLIWTRSKKNKQSILNINDVQEEDLLRLGNLRSFTFKELQLATDNFSSKNILGAGGFGNVYRGKLGDGTMIAVKRLKDVTGTAGESQFRTELELISLAVHRNLLRLIGYCAIPNERLLVYPFMSNGSVASRLKGKPALDWNTRKRIAIGAARGLLYLHEQCDPKIIHRDVKAANVLLDDYCEAVVGDFGLAKLLDHADSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLIELITGMKALDLGKTVNQKGAMLEWVKKIQQEKKIEVLVDRELGINYDRIEVGEMLQVALLCTQYLPAHRPKMSDVVRMLEGEGLAEKWAASHNYPNQGTNLPPLIHGSQIRLHHATVPGHDDNVYDQSAMFEMITMDEDYDAYAMELSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U595</accession>
    <name>A0A068U595_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00041900001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U595"/>
    <dbReference type="FunCoup" id="A0A068U595">
        <property type="interactions" value="1830"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U595"/>
    <dbReference type="Gramene" id="CDP03349">
        <property type="protein sequence ID" value="CDP03349"/>
        <property type="gene ID" value="GSCOC_T00041900001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U595"/>
    <dbReference type="OMA" id="KAVPNQM"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U595"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP03349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="144" mass="15878" checksum="42BA917EEAFF5526" modified="2014-10-01" version="1">MPSRFQGAIKQEWEPVVLQKSRPKAQDLRDPKAVNQALRTGGQVQTIKKADAGANKKAAPPAVNARKLDEAEEPAALGRVSTEVRQAIQKARIEKKMSQAELAKQINERPQVVQEYENGKAVPNQAVLAKVERVLGVKLRGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6M0</accession>
    <name>A0A068U6M0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017453001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6M0"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6M0"/>
    <dbReference type="Gramene" id="CDP04146">
        <property type="protein sequence ID" value="CDP04146"/>
        <property type="gene ID" value="GSCOC_T00017453001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6M0"/>
    <dbReference type="OMA" id="ILCDVWG"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07525">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000124">
        <property type="entry name" value="HAD-family hydrolase IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006356">
        <property type="entry name" value="HAD-SF_hydro_IIA_hyp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF-IIA-hyp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF90">
        <property type="entry name" value="OS08G0542600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="306" mass="32929" checksum="2664CAA8010A2382" modified="2014-10-01" version="1">MPDSLKPFQTLTGIQQLAESHKFKGWLLDQFGVLHDGKKPYPGAISTLEKLANFGAKMVIISNSSRRACTTLEKLKSLGFDPSLFVGAITSGELTHQHLQRRDDPWFAALGKSCIHMTWKDRGAISLEGLGLQVVENVEEAKFILAHGTEALGLSSGAATPMKLGDLEKVLEECAAKNIPMVVANPDFVTVEARDLRVMPGTLATKYEKLGGKVKWMGKPDKIIYKAAAEMAAIDPSQCVAIGDSLHHDIKGANAAGISSAFITGGIHATELGLDTFGEIADDSSVVALALRHDAYPSYVLPSFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6V5</accession>
    <name>A0A068U6V5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="5">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00017517001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6V5"/>
    <dbReference type="FunCoup" id="A0A068U6V5">
        <property type="interactions" value="2437"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6V5"/>
    <dbReference type="Gramene" id="CDP04201">
        <property type="protein sequence ID" value="CDP04201"/>
        <property type="gene ID" value="GSCOC_T00017517001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6V5"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6V5"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000025">
        <property type="entry name" value="isopentenyl-diphosphate Delta-isomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP04201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="235" mass="27231" checksum="354C27E3F8900229" modified="2014-10-01" version="1">MGDAIADAAMDVVQRRLMFEDECILVDENDRVVGHDTKYNCHLMEKIESENLLHRAFSVFLFNSKFELLLQQRSATKVTFPLVWTNTCCSHPLYRESELIEENVLGVRNAAQRKLLDELGIPAEDLPVDKFTPLGRMLYKAPSDGKWGEHELDYLLFIVRDVKVNPNPDEVADVKYINREQLKELLRKADAGEEGLKLSPWFRLVVDNFLFKWWEHVEKGTLLDAVDMKTIHKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U716</accession>
    <name>A0A068U716_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 734A1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00041983001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP03408.1"/>
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        <property type="gene ID" value="GSCOC_T00041983001"/>
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        <property type="component" value="Chromosome VIII"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="term" value="P:response to jasmonic acid"/>
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        <property type="entry name" value="Cytochrome P450 734A1"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF224">
        <property type="entry name" value="CYTOCHROME P450 734A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP03408.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62895" checksum="DA2713FF93DEACB8" modified="2014-10-01" version="1">MEEEKLLHCLKLLLISFLLSYFMHKVLVLLWWRPRKIEEHFSKQGIRGPPYRFLVGNAKELVSLMLKASSQPMPFSHNILPRVLSFYHHWRKLYGATFLVWFGPNVRLTVADPDLIREIFTSKSEFYEKNEAHPLIRQLEGDGLLSLKGAKWAHHRKIITPTFHMQNLKLLIPMGASSVVEMLDKWFAPANGSGEGNEIEIEVSEWFQNLTEDIVTRAAFGRSYEEGKAIFRLQAQQMVLASEAFQKVSIPGYRFLPTRSNMKSWKLDKEIKKSLMKVIDQRKENWGSEIKENGPKDLLGLMIKASMKEASSSSSWARESNADSNSNLCPFPSSVITVKDIAEECKSFFFAGEQTTSNLLTWTTVLLAMHPEWQDRARDEVLKVCGPRDIPSKDDLVKLKTISMILNESLRLYPPIVATIRRAKADMELGGCKIPSGTELLIPILAVHHDHALWGNDANEFNPARFSEGVARAAKHPVAFIPFGLGVRQCIGQNLAILQAKLTLAIMLQRCTFRLAPRYQHAPTVLMLLYPQYGAPIIFRPLSHPVTPQNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7Y5</accession>
    <name>A0A068U7Y5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017610001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP04274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP04274"/>
        <property type="gene ID" value="GSCOC_T00017610001"/>
    </dbReference>
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        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657699" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="100" mass="12137" checksum="354B3C054EA8CA93" modified="2014-10-01" version="1">MLPCLYISCIYILVHVVYRTIKGEEVETMERMFFQCPIAQIVWKIAPVRWEGLRDLQTNMWRWWEAVVQTRTKEQGMEQINLTTNILWLIWKARNKFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9R9</accession>
    <name>A0A068U9R9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RWP-RK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00019964001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068U9R9"/>
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        <property type="protein sequence ID" value="CDP05047"/>
        <property type="gene ID" value="GSCOC_T00019964001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9R9"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9R9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044607">
        <property type="entry name" value="RKD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003035">
        <property type="entry name" value="RWP-RK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46373">
        <property type="entry name" value="PROTEIN RKD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46373:SF2">
        <property type="entry name" value="RWP-RK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02042">
        <property type="entry name" value="RWP-RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51519">
        <property type="entry name" value="RWP_RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RWP-RK" evidence="7">
        <location>
            <begin position="143"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="273" mass="30516" checksum="8AA7716516BF704E" modified="2014-10-01" version="1">MNPPALSVVYQLENLLASDGSLYFEEQPPSGAWEQSYLAFPESLGQCTAGICNCKEPLHAWKWKNNSIPCLEMEFKDFEDICGDFGWHSPPDVKEPFFEGDVNVVDAKPLNAAGEIRDQALLENGETVFGEASGGNAVCSRSSEPLVSDDGLVSGRYKSSALEVDEIQKYFDVPITKAAKELKVGLTVLKKRCRELNIRRWPHRKIKSLKSLIDSAKELGLTSEIEMLEEHKRMLKVLPEMELTERTKKLRQACFKANYKKRRAMAAAAAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9X5</accession>
    <name>A0A068U9X5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Growth-regulating factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00019895001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription activator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GRF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9X5"/>
    <dbReference type="STRING" id="49390.A0A068U9X5"/>
    <dbReference type="Gramene" id="CDP04999">
        <property type="protein sequence ID" value="CDP04999"/>
        <property type="gene ID" value="GSCOC_T00019895001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9X5"/>
    <dbReference type="OMA" id="MMANCDN"/>
    <dbReference type="OrthoDB" id="1937002at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9X5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031137">
        <property type="entry name" value="GRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014977">
        <property type="entry name" value="WRC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602:SF101">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08879">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51667">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="7">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="WRC" evidence="8">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="4">
        <location>
            <begin position="272"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="590" mass="62416" checksum="71AE281D6AA7CE94" modified="2014-10-01" version="1">MEESSSSSSSSAGIITTASHRTQSFPSNNSVMDHHHRPLLSSANGADDDDEEDDGGGRGSGRSQNDSGPNEVERSPAPTPTPTPKPPNYSCHHSSSTGPSRTSSSSATTTSTSTGIVFPDRVVVVTNNGSATAGLAAAAAATTLQPFDFPCSITNTASKSPGGGGLGMAAASAALGFPFTAVQWKELERQAMIYKYMIASVPVPSDLLLPADPTAAPLLLGGSHGGGGSIYNLRYGNRDLEPGRCKRTDGKKWRCSRDVAPHQKYCERHMHRGRPRSRKPVEQLQSSSVSPDDNPNNNISKKSRLHHTSLHPNPTVAQPDNHSSPQFQGTGTIQQLKDPQLLDASIAFNSIFASSCNYKESNRVFGWAVDGEVMAANRVEQESLHLMDTRRREGLAPIRGYIYGTNASTLQQGYGEEGPLNLFSYATEIAYPGGIHSRNDEHYHAFLNSDLIASKQPQMDQHWNGLSPSSLPLSMAMAAGNALDEGTGLAEDSHPRMPTPKDSPVSWLPLIPGGPLAEVLQPNSVACGSNPASPYASNGDSVSPPATTVSSPTGIFQRALFSHSDGSVCNSPALAASAAPPEVVAFQWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBA7</accession>
    <name>A0A068UBA7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00021130001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBA7"/>
    <dbReference type="STRING" id="49390.A0A068UBA7"/>
    <dbReference type="Gramene" id="CDP05835">
        <property type="protein sequence ID" value="CDP05835"/>
        <property type="gene ID" value="GSCOC_T00021130001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBA7"/>
    <dbReference type="OMA" id="IWIDELI"/>
    <dbReference type="OrthoDB" id="785331at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBA7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
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        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
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        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
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        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Bulb-type_lectin_dom"/>
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        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Pan_app"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="S_locus_glycoprot_dom"/>
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    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
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    <dbReference type="PANTHER" id="PTHR32444:SF183">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="PAN_2"/>
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    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_locus_glycop"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="BULB_LECTIN"/>
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        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654746" description="Receptor-like serine/threonine-protein kinase" evidence="16">
        <location>
            <begin position="27"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="18">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="19">
        <location>
            <begin position="317"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="487"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="783"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP05835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="803" mass="89421" checksum="27BCBA13322E8D98" modified="2014-10-01" version="1">MRTLVKGILLLFPISILFLTQKIACATDTLTTTQFIKDGETIISAGGSFALGFFSPSNSNNRYVGIWYQKISIPTVVWVANREVPLVNTSGVLEVIKPGLLVLRNGTNSIIWSTNSSTSVPNPVAQLLETGNLVVKDENQDNLEMFLWQSFDYPTDTFLPGMRLGQNFVTGLEVYLSSWKSYEDPAPGGYTYHCDPTGYPQNFIKKDSSLEFRTGPWNGLGFSGVPSLAKNPIFSYQVVIDNKERWTWDNQTGSWLIYLSAPTDNCDSYGLCGAYGTCNTGNSATCGCLDKFSPKNPEKWANGDRSGGCSRRIPLDCKSGDGFLKYSSLKLPDTRNSSYNTNISLEECRTVCLKNCSCTAYSILDISNGGSGCLLWFGDLIDIKVMSQGGEDIYIRMAYSESVSLQSSVGKKGKKLAISLTLSLAMVLFALGLILYLQRRKKKLAKQKKEELSGHNFSMAYTDEHNKKDLELPLLELSRIIKATNNFSFQNKLGEGGFGPVYKGLLEDGQEVAVKRLSEYSMQGLDEFKNEAICIAKLQHRNLVKLLGCCIEGREKILIYEYMPNKSLDFFIFDQTGRYSLDWPMRFHIIQGIARGLLYLHQDSRLRIIHRDLKASNILLDADMNPKISDFGTARSFGGNETGANTNRVVGTHGYMPPEYAVDGIFSVKSDVFSFGVIVLEIVSGKRNRGFLHHDHQFNLLGHAWKLYKEGRELELVDLHLGDSYNSLQVLRSIQVGLLCVQHGPDDRPDMSSAIFMLGNDGVLPEAKHPGFFMERNVVNEHSSSTQTSSSRGEITMTLLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEB8</accession>
    <name>A0A068UEB8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00023802001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEB8"/>
    <dbReference type="FunCoup" id="A0A068UEB8">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEB8"/>
    <dbReference type="Gramene" id="CDP06811">
        <property type="protein sequence ID" value="CDP06811"/>
        <property type="gene ID" value="GSCOC_T00023802001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEB8"/>
    <dbReference type="OMA" id="WDSETTH"/>
    <dbReference type="OrthoDB" id="664875at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEB8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020983">
        <property type="entry name" value="Basic_leucine-zipper_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46408">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46408:SF10">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12498">
        <property type="entry name" value="bZIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="270"/>
        </location>
    </feature>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Lan T."/>
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</entry>
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            <fullName evidence="1">glutathione transferase</fullName>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEQ5"/>
    <dbReference type="STRING" id="49390.A0A068UEQ5"/>
    <dbReference type="Gramene" id="CDP06108">
        <property type="protein sequence ID" value="CDP06108"/>
        <property type="gene ID" value="GSCOC_T00021494001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEQ5"/>
    <dbReference type="OMA" id="FKILECE"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEQ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF773">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="214" mass="24513" checksum="DA6A09886B7CADC3" modified="2014-10-01" version="1">MLDHEYSPPANRVIIALKEKGVAFVSKQEDLPNKKSSLLLEMNPVHKQIPVLIHNGKPICESLIIVEYIDEVWNDKSPLLPTDPHDRAHSKFWADYIDKKIYTSARPVLTTKGETQAAAMKELISSLKILDAELGDKPYFGGKTFGITDIALVPLYSRFYTLEKFGNLKMNEECPKLVAWGERCLERESVSTTLHNQYETYDFMLEIWKKLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEU2</accession>
    <name>A0A068UEU2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00024206001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEU2"/>
    <dbReference type="FunCoup" id="A0A068UEU2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEU2"/>
    <dbReference type="Gramene" id="CDP07090">
        <property type="protein sequence ID" value="CDP07090"/>
        <property type="gene ID" value="GSCOC_T00024206001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEU2"/>
    <dbReference type="OMA" id="ICLMSMK"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEU2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23114">
        <property type="entry name" value="RING-H2_WAVH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01466">
        <property type="entry name" value="vWA_C3HC4_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032838">
        <property type="entry name" value="Vwaint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF158">
        <property type="entry name" value="RETROELEMENT POL POLYPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14624">
        <property type="entry name" value="Vwaint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="282"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="79500" checksum="B01028C3AC28628C" modified="2014-10-01" version="1">MGSKWRKAKLALGTKMCLHVPRTTEEPSPAPALALAPTSAGRFSDAVSLSPTPHRGSNCRLDMPTTPVPSSSGLRLPKHSSKSSKKNCAICLNSMKAGQGHAIFTAECSHSFHFHCITSNVKHGNQICPICRAKWKEIPFQSPAIEVTRGRTRINNVSLPQNDPWVTVLRRLPPPRVDTSRHVSSLFQTTEPSVFDDDEIIHYQPETMENNSSLNDLIADNSAGAIDLKTYPEVSAISKQAWHSNFTILIHLKAPHTIVPKQVGVDQSGSQMVPQHSRVPVDLVTVLDVSGSMAGTKLALLKRAMGFVIQNLGPSDRLSIVAFSSTARRVFPLHRMTDTGRQEALQAVNSLSSNGGTNIAEGLKKGAKVMTDRKSKNPVSSIMLLSDGQDTYSLSSPGAANSRTNYQFLLPVSMHRGSGAYSHIPVHTFGFGADHDAVAMHSVAETSGGTFSFIEAEDVIQDAFAQCIGGLLSVVVQELLVQVECIHPRLRLSSIKAGSYKTSLISNERIGSIEVGDLYADEERDFLVTTDIPVDKSSDEMSLVKIKCVYKDPVSKELVTANHAAEVKILRPETTGQLVVSMEVDKQRNRLRSAEAMAEARAAAEGGDLAAAVSVLEHCRKQLADSVSHKAGDRLCIALDAELREMQERMADRQIYETSGRAYVLSGLSSHSWQRATARGDSTDSTSLVQAYQTPSMVDMVSRSQTMLIGSPSPRRSLRPVRSFPARPMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEU4</accession>
    <name>A0A068UEU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_1225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00008984001</name>
        <name evidence="1" type="ORF">GSCOC_T00021536001</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DH200</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">DH200</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP06143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEU4"/>
    <dbReference type="Gramene" id="CDP06143">
        <property type="protein sequence ID" value="CDP06143"/>
        <property type="gene ID" value="GSCOC_T00021536001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP20462">
        <property type="protein sequence ID" value="CDP20462"/>
        <property type="gene ID" value="GSCOC_T00008984001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="86" mass="9441" checksum="8B789B5253941BFA" modified="2014-10-01" version="1">MDRISDVCIDHGPQNDPVRVLLGLVTHAQAKFLKKSLQGLVQTVQDQHGVHRDIEGLEGDKQNIYTMIQAHGESSGPPSDWAELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEV3</accession>
    <name>A0A068UEV3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00024216001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CDP07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Gramene" id="CDP07100">
        <property type="protein sequence ID" value="CDP07100"/>
        <property type="gene ID" value="GSCOC_T00024216001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEV3"/>
    <dbReference type="OMA" id="SCSPWKV"/>
    <dbReference type="OrthoDB" id="406981at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heparan sulfate 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:stem cell population maintenance"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Heparan_SO4-6-sulfoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812">
        <property type="entry name" value="HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812:SF0">
        <property type="entry name" value="HEPARAN-SULFATE 6-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657607" description="Sulfotransferase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGB6</accession>
    <name>A0A068UGB6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00024374001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00024374001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGB6"/>
    <dbReference type="OMA" id="RRMAPKS"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGB6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF25">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="86" mass="9784" checksum="E954B894DF26C080" modified="2014-10-01" version="1">MGIDLKAGGKVKKTKRTAPKSDDIYLKLLVKLYRFLERRTGSRFNAVLLKRLFMSKIDKPPLSLSRLVKFMEGKEDKIAVLVGTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHI0</accession>
    <name>A0A068UHI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00025457001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate(in) + H(+)(in) = phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:29941"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHI0"/>
    <dbReference type="STRING" id="49390.A0A068UHI0"/>
    <dbReference type="Gramene" id="CDP07936">
        <property type="protein sequence ID" value="CDP07936"/>
        <property type="gene ID" value="GSCOC_T00025457001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHI0"/>
    <dbReference type="PhylomeDB" id="A0A068UHI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP07936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28882" checksum="34A941DFA24D6E55" modified="2014-10-01" version="1">MSVYANKKTRGYFIAAVSIFNARFKAPSYAIDPHGSTVAQADYVRRIVLMAGAIPALLTYYWRMKMRENYTIHGSGCQESKTRCSRHVKKLKIQKLKLELGLELEMDLVYSPRSFFVTGFRLLGTKTTRFFLDTLFYSQNLFQNMIQSFVVVLCALTFFFANFRPNATAFVAPAEIFPARLRTTCHGISAASGKLGAIVGGIEFLYLSRNKDKAGTAAGYRPGIGMRNSLNVLAVINLSGALFTQPIGMFCKQKPIDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UID7</accession>
    <name>A0A068UID7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026960001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UID7">
        <property type="interactions" value="1183"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UID7"/>
    <dbReference type="Gramene" id="CDP08201">
        <property type="protein sequence ID" value="CDP08201"/>
        <property type="gene ID" value="GSCOC_T00026960001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UID7"/>
    <dbReference type="OMA" id="MHASRMK"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UID7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000431">
        <property type="entry name" value="Tetratricopeptide repeat (TPR)-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1903"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2002"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1907"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1939"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2002"/>
            <end position="2030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2057" mass="229926" checksum="812C9E757DA73777" modified="2014-10-01" version="1">MVYFSGFTIRFLQFFFSPDNGNSAFLFSIAAINDTDSKKQWEPLAPTKEAQEFHLSQIYHEGLAKLQAKDYKKARELLESVLKDPMVSSAQVDNNVSDGHLLQLRFLVLKNLATVFLQQGPTFYENALQCYLQAVEIDNKDSVVWNQLGTLSCSMGLLSISRWAFEQGLFCSPNNWNCMEKLLEVLIAIGDEVACLSVAELILRHWPSHSRALHVKTTIEGFEPIPFAPRGIDKLEPKHIRLKFPEKRKAENDDLIDGAPSKKLKQTIEVQLSEPSWTALAGELLQLLNSFVSASPDQERGQYKSGDVSLSIRLPHTSGSGMETLESKGSMLTTSSEDMPFANCNFEKNSHTKEKEANVSEEQPQERRSSRIERLRSRKPGKEDSDFGTTRDLAKVIVQFLRPFIAGGGGSDDYTTDASTSSDCAEIVTRSQDSESTDVIRFVEKTSENYGAYHMSHLILEEIASRCIFFQDSNAKFLDLEKLTRQWGKERTPECSLFLAELYYDFGLRSPDSSTSEYMSEASYHICKVIECVALECPLQSLAVASHDNLSSRESLSDPCKIAVDNSHPLSNDFPFWVRFFWLSGRLSMVDGNKAKAQAEFSTSLSLLVNKENKNESTSSICLPHCKVIHKLTVDRILSEINLLEVDFLMKKTVHEMIGKNMYSECVDMLVPLLFSAKDVHLDVGNVSGLDEGFTNVELSAIDALIKACEQAMSMDIEVYLKCHRRKLQILISAAGLGDYPPSIKSHGLNVFSSSETEAKDSACIYWNHIVAEEVKAISGCTSRIKSMIPCDHLNGVIGPMKVIKDIQSILLVLMCNVANKYLCKKSSGLGISDENLQGQICYFVDAAIAFCKLQHLSPIVPIKTQTELIVAVHDMLAEFELCCAHGNDDEEGGTFLKFAIKHLLALDMKLKSNCQNQSKAEYQVQSSGQISPVFQIDGSVNEAKIIEQATDVDHTDEISTPEKDATEGNYSESFCTQERLKKEETGVECDRNVGARPNSVFLERQKEKEDTQSIESGKEMTEDEREELELGIDNALDQCFYCLYGLNLRSDSSYEDDLAIHKNTSRGDYQTKEQCADVFQYILPYAKASSRTGLIKIRRVLRAIRKHFPQPPDHVLVGNAIDKILDDPDLCEDKLSEEAGCDGFLDSVIKTVFSDPGSLKQQQASLVVSSGPYHDVYSNLYYFLALSEEMSATDKWAGFVLTKEGEEFVEQNAKLFKYDLLYNPLRFESWQRLANIYDEEVDLLLNDGSKQINVLGWRKNPTLPQRVEKSRRRSRRCLLMTLALAKTAIQQGEIHELLALVYYDGVQNVVPFYDQRSMIPSKDAVWMMFCQNSMRHFKKAFEHKEDWSHAFYLGKICEKLGCSHDTSLSYYAKAIALNPSAVDPFYRMHASRLKLLCTCGKQDQEAMKVVAAYSFMESTKQTIMSTLGIVGGEILEPSMHSEKRNLADNCAGNMVEVAKLEEVWHMLYNDCLSALEICVEGELKHFHKARYMLAQGLYRRGGSGDLDKAREEISFCFKSSRSSFTINMWEIDSMVKKGRRKTPSVSVNRKPLEVNLAESSRKFITCIRKYILFYLKLLEETGDVSTLDRAHVSLRSDKRFSPCLEDIVPVAIGRYIKTLILSIQQSLSCSDPTRGAIEHLLEKLFSLFLDQVNLWSDICNLPEIKTPELTESYLYGYLYQYIQCLERSVKVEALEGINEKIRKRLKNPKLSNSNCAKVYKIVSVAWCRSLVISMALITPLHSRIPSEIHVPGSLGSGLENIQLLCVDLQSDELWSSSSDDLEHLKCLETKWNPSLSKIKNVIVKRVSDEDLETAAILLRSSYNFYKDTSCALLPSGINLYTVPSQLATETYVQPGIDGVDILDMNTSRKLLLWAYTLLHGYCPNLSVVIKYCEENVKVKMKKGTGTPLTPSNTNVPSGSASNTGGGKDGTGKSNEVDTSSISSATAASLPEIDTTTKMASSPLPEKLEPSNVASASLQGTEACNLASVSPTETKIICSVSSTSMPDSGSTNLPNVVSSNENQGFPSATSDLLDCNVVPTEMSRVDIEGASDLTSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIG0</accession>
    <name>A0A068UIG0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Legumain prodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00026996001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIG0"/>
    <dbReference type="FunCoup" id="A0A068UIG0">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIG0"/>
    <dbReference type="Gramene" id="CDP08231">
        <property type="protein sequence ID" value="CDP08231"/>
        <property type="gene ID" value="GSCOC_T00026996001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIG0"/>
    <dbReference type="OMA" id="RSFETYC"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIG0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.130:FF:000001">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000005">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043577">
        <property type="entry name" value="AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF50">
        <property type="entry name" value="VACUOLAR-PROCESSING ENZYME GAMMA-ISOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500139">
        <property type="entry name" value="AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657703" description="Legumain prodomain domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="10">
        <location>
            <begin position="375"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="488" mass="53805" checksum="A51679546613FAE6" modified="2014-10-01" version="1">MMRYATAALLLLALSIIAVAEARDNFLKLPSEIADFFHPKERSDAGGDSVGTRWAVLIAGSNGYWNYRHQADVCHAYQILKRGGLKDENIVVFMYDDIAYNEENPRPGVIINSPHGADVYQGVPKDYTGDDVNAKNFLAAILGDKTAITGGSGKVVDSGPNDHIFIYYTDHGGPGVLGTPSGPYLYADDLNEVLKKKHASGTYKSLVFYLEACESGSIFEGLLPEDLNIYATTASNAEESSWGTYCPGEYPSPPPEYETCLGDLYSVAWMEDSEIHNLHTETLKQQYHLVKKRTSSSNSAYGSHVMQYGDLKLSLEDLFLYMGTNPANDNYTFVDENSLRPSSKAVNQRDADLLHFWDKFRKAPEGSARKVEAQKQVVEAMSHRMHIDNSVKLIGKLLFGIEKGSEILNSVRPAGHPLADDWDCLKSLVRTFETHCGSLSQYGMKHMRSIANICNAGIKKDQMAEAAAQACVSLPSNSWSSLHRGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIP8</accession>
    <name>A0A068UIP8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027148001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIP8"/>
    <dbReference type="FunCoup" id="A0A068UIP8">
        <property type="interactions" value="1516"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIP8"/>
    <dbReference type="Gramene" id="CDP08346">
        <property type="protein sequence ID" value="CDP08346"/>
        <property type="gene ID" value="GSCOC_T00027148001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIP8"/>
    <dbReference type="OMA" id="VTFAIKC"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001725">
        <property type="entry name" value="Kinase like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001893">
        <property type="entry name" value="Probable serine/threonine-protein kinase DDB_G0291918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="367"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="878" mass="98323" checksum="AA5F8278688BEFBD" modified="2014-10-01" version="1">MNLELPLLVDIYAILIDFLFHLLAYFSDGNMSRDITLQSFEPPAVAFDALELEKAMLRTSLLLDSSDELPKFNRAETGYGNEKVTDFFVNRDEVNYASRRGCQFDSLDSRGCQNFLPSISEHRVKAVPFSEMNHLAMLQSPFGSMEDNVNEESSFRKIRFTGTSRLQLYQETQHSQKEVVPVVDPCESGNEDKIFMQSNQEEPHRANDENCLIDMNKIDGLQEDKLLKNISEDCSSMIPSIEKGKVIKLPNSQATLTASGLSVGQNPIAKISHKSKTDQKQAPSQRLHSIDRTLENANAAFSPLQKLQTRTDKKSIPMKQHMKYYGHQDMNVKEKKENLDKNREPSVNPSHVSLLGQQRVLPNFEPFIVEEEEGSGGYGTVYRARRKSDGVTFAIKCPHVNANRNHVHNELKMLERFGGKNFVIKYEGSFKNGDSDCLVLEHVEHDRPEVLKRDIDVCELQWYGYCMFRALAGLHKQGIVHRDVKPGNFLFNRKACKGYLIDFNLAMDLNQKYGTADKTKLSHDVSLNSVPLSRAISIPPSKSRKILTPKAVELANREQGKVLKPLLISKDTRKKIQNSNHCAEVGSRSAIKSQGADGSGITSAREATSTKTLSAEKFREPLPSQGRKELINLVQEALQGANRGSANVPVSKRKRIAATPAKVDRKFLYITPMPLHSAGGVVGGAGVLKNKGDGKNKREGPCVGTKGFRAPEVLFRSLHQGPKVDIWSAGVTLLYLLAGRTPFAGDPDQNVKEIAKLRGSEDLWEVAKLHGRESSFPAGLLDIKSLPSIKLQDWCKHNNRRPDFLEVIPGSFFDLVDKCLTVNPRLRISAEEALRHEFFTPCHEALRKHRLLRQEASLDSASSSFLLHEQSKKCAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKF1</accession>
    <name>A0A068UKF1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00027853001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKF1"/>
    <dbReference type="STRING" id="49390.A0A068UKF1"/>
    <dbReference type="Gramene" id="CDP08762">
        <property type="protein sequence ID" value="CDP08762"/>
        <property type="gene ID" value="GSCOC_T00027853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKF1"/>
    <dbReference type="OMA" id="TYYHVQS"/>
    <dbReference type="OrthoDB" id="1923658at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051863">
        <property type="entry name" value="HIPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811:SF35">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP08762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20936" checksum="8B9FA090FC069A51" modified="2014-10-01" version="1">MKKFIFGLDLHDDKEKRKALKTVAALQGIDEMTIDLKGKKLTIIGTVDPVDVASKLRKFWPTGIIAVGPAKEPEKKEEPKKEEAKKDEAKKEEGKEEPKKEESKKDEPKKEEPKKDEEKQAPEPAPVQVQVPVPVQVPVMPYRPYYPPMQSSVMPYRPYYPPMQTYYYPNHSVEENPNGCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKH5</accession>
    <name>A0A068UKH5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="8 9">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00027744001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="8 9"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKH5"/>
    <dbReference type="STRING" id="49390.A0A068UKH5"/>
    <dbReference type="Gramene" id="CDP08689">
        <property type="protein sequence ID" value="CDP08689"/>
        <property type="gene ID" value="GSCOC_T00027744001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKH5"/>
    <dbReference type="OMA" id="QAGKYIW"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKH5"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF87">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP08689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="659" mass="73735" checksum="0BC8FFB691C26EA0" modified="2014-10-01" version="1">MAAEKFIVKIEEAKEGENGRASRGPVYRNVLAKDGFKPLPPGLHSCWDIFFESVKEYPNNRMLGEREMVKGKAGEYSWLTYKQVYDLVLEVGNSIRTCGVVQGDKCGIYGANCSKWVVSMQACNAHGLYCVPLYDTLGAGAVEYIICHAEISIAFVEETKISEVLKTFPTTGKYLKTVVSFGKVSNEQKEVSGTFGLKIFSWDEFLLLGWGQQYDLPIKKRKDTCTIMYTSGTTGDPKGVMISNEAVLSIISGVNHHLESINEEFSERDVYLSYLPLAHIFDRVIEELLIFKGAAIGFWHKDVKQLVDDIRKLTPTVFCSVPRVLDRIYSGLVEKLSSAGLLKYTLFNIAYSYKLRNMSKGYKHVDAAPRFDKIIFNKVKEGLGGNLRLILSGAAPLSSSVETFLRVVTCAHVLQGYGLTETCAGSFVAQPDVLAMIGTVGPPLPIVDVCLESVPEMGYDALASTPPRGEICIRGKCLFSGYYKREDLTEEVMIDGWFHTGDIGEWQLDGSMKIIDRKKNIFKLSQGEYVAVENLENNYSLASCIDAIWIYGNSYESFLVAVVNPNIESVERWAEENGQTGHFSALCESPSAKAYILEELSKIGKEKKLKGFEFVKAVHLDPTPFDMERDLLTPTYKKKRSQFLRYYQDVIDGLYKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM27</accession>
    <name>A0A068UM27_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028569001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="2"/>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM27"/>
    <dbReference type="FunCoup" id="A0A068UM27">
        <property type="interactions" value="1387"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UM27"/>
    <dbReference type="Gramene" id="CDP09279">
        <property type="protein sequence ID" value="CDP09279"/>
        <property type="gene ID" value="GSCOC_T00028569001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM27"/>
    <dbReference type="OMA" id="CYRTREV"/>
    <dbReference type="OrthoDB" id="427950at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM27"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000019">
        <property type="entry name" value="Probable GTP diphosphokinase CRSH, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000025">
        <property type="entry name" value="probable GTP diphosphokinase CRSH, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21262:SF12">
        <property type="entry name" value="GTP DIPHOSPHOKINASE CRSH, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21262">
        <property type="entry name" value="GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="509" mass="57274" checksum="3A38DC0E61C04BCF" modified="2014-10-01" version="1">MVAELVGAFNHSSNSNCSSNLSTSSSRLLFKTLKLAIPILQALPPTPPGHRPPLSKALSVAFILADLQMDAEVISAGILRQVLEAGAMSFFQVKDRIGTSTAHLLHESLRLNNIYSKVQILDDDSAAALRKYCLTCYDSRALILDLALKLDSMRHLNYLPRYQQQLISLEVMKIHAPLAHALSTNILSLELEDLSFRYLFPYSYVYVDTWLGSHQTSGSEHLLDIYQEQLLQSLRSDPILTEIVDDISVKARSKSRYSTMKKLLRDGRKPEEVYDILGLRVILSPSQVNSSQLGEKACYRTREIIRSLWKEIPSRSRDYIARPKANGYRSLHMVVDISDSGRHRPMMEIQIRTAEMDMLAADGTASHALYKSGLTDPEEAKRLKAIMIAAAEFAAMRLQDLPSANTRCLEIDRRDRVFCLLDKDGDGKISIEELMEVMEELGAEGEDAREMMELLDSNSDGSLSSDEFDLFQKQAELMRNLDARDDQYKTLLDEKLQISDSSGVIQAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM31</accession>
    <name>A0A068UM31_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00028574001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM31"/>
    <dbReference type="FunCoup" id="A0A068UM31">
        <property type="interactions" value="1524"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UM31"/>
    <dbReference type="Gramene" id="CDP09284">
        <property type="protein sequence ID" value="CDP09284"/>
        <property type="gene ID" value="GSCOC_T00028574001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM31"/>
    <dbReference type="OMA" id="IWNWGAN"/>
    <dbReference type="OrthoDB" id="239701at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM31"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="457" mass="48768" checksum="7FBEDBA1B6BA50C5" modified="2014-10-01" version="1">MAISLRYLRTQHQTLGRHYFHFNYSTKNPTNKAVPLLWDYRESGSTAQEAVTVQLHSWGRGASGQLGGGIEEIRIYPAAVASLLLPPSFTLSSPIPGRLSVSESSAENENEVVKVGISCGLFHSALLVNGQLWIWGKGDGGRLGLGHEEPVFVPTLNSHLGSNLVKCVALGGVHSVVLNSLGQVFTWGYGGFGALGHSVYHRELLPRLVEGPWTEEIYHIATSGTHTAAITKSGELYIWGRDEGDGRLGLGPGRGPNEAGGLSIPSKVRALPMPVAAVSCGGFFTMALSKEGRLWNWGANSNYELGRGDKLGGWKPQPVPSLKDVRIVQIASGGYHSIALTDKGEVFTWGHGGHGQLGHSNIQNHKVPLRVEALANEKVTYVACGGSSSAAITDEGKLYMWGNAKDCQLGIPGLPEVQPSPVEVKFLTEDDGSTIDKVLSIAIGASHVMCLVTRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM40</accession>
    <name>A0A068UM40_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028694001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM40"/>
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    <dbReference type="Gramene" id="CDP09362">
        <property type="protein sequence ID" value="CDP09362"/>
        <property type="gene ID" value="GSCOC_T00028694001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM40"/>
    <dbReference type="OMA" id="FHYSRIP"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM40"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="24997" checksum="AE1AA2068D3355C7" modified="2014-10-01" version="1">MFHYSRIPVASYYRITYCMLVRRQVQMIFLQMGFEEMPTNNFVESSFWNFDALFQPQQHPARDSHDTFFLKEPSTTKILPEDYVDRVKEVHENGGYGSRGYGYEWKREEANKNLLRTHTTAVSSRMLYLLAQKPFAPKKYYSIDRVFRNEAVDRTHLAEFHQIEGVMCDRGLALSDLIGVLHEFFSRLGMSKLRFKPAYNPYTEPSMEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMX4</accession>
    <name>A0A068UMX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030032001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMX4"/>
    <dbReference type="FunCoup" id="A0A068UMX4">
        <property type="interactions" value="1274"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMX4"/>
    <dbReference type="Gramene" id="CDP09637">
        <property type="protein sequence ID" value="CDP09637"/>
        <property type="gene ID" value="GSCOC_T00030032001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMX4"/>
    <dbReference type="OMA" id="WMREDLM"/>
    <dbReference type="OrthoDB" id="759501at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009960">
        <property type="term" value="P:endosperm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056708">
        <property type="entry name" value="DUF7806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35489">
        <property type="entry name" value="TITAN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35489:SF2">
        <property type="entry name" value="TITAN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25091">
        <property type="entry name" value="DUF7806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7806" evidence="3">
        <location>
            <begin position="211"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="307" mass="35574" checksum="F45C9D8626A6F09A" modified="2014-10-01" version="1">METLYTKLYDKYIKLKKEKDTAMENLNRDQEKKFMNYVIASDEMIEFLRSENERLGNQVSELRSEMALSTKDEECIQYNKLLMEENQNNKKLQEEIERLRNLQREGRCCQARDDKVDGAVDMPVSSQVESYSSDGTSVRKTRKRSRHSLHDRGDTITPSATKEHEHEQLNVLPNRSCKETEASDTPSDHYDVLQLAICKRKMNNPGSDVAASCMFQELVEWVVGLKLSIIPQSRDFCISALHPSSGYSFTLTWVNNSKGEPELLYHVLALGTFERVAPEWMRDVLMFSMSMCPTFFHRVSRVIQLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPR5</accession>
    <name>A0A068UPR5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Syntaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00031298001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPR5"/>
    <dbReference type="STRING" id="49390.A0A068UPR5"/>
    <dbReference type="Gramene" id="CDP10540">
        <property type="protein sequence ID" value="CDP10540"/>
        <property type="gene ID" value="GSCOC_T00031298001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPR5"/>
    <dbReference type="OMA" id="MKEIMIR"/>
    <dbReference type="OrthoDB" id="1730528at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntaxin N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="9073" checksum="100FA265F4C14243" modified="2014-10-01" version="1">MNDLLTDSFVIPREETSRNGDIEMGTQQPMNSGELGLDNFFKKVQEIENQYEKLNKLLKKLQDAHEESKAVTKASAMKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQK1</accession>
    <name>A0A068UQK1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00031707001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739132">
        <property type="protein sequence ID" value="CDP10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQK1"/>
    <dbReference type="FunCoup" id="A0A068UQK1">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQK1"/>
    <dbReference type="Gramene" id="CDP10820">
        <property type="protein sequence ID" value="CDP10820"/>
        <property type="gene ID" value="GSCOC_T00031707001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQK1"/>
    <dbReference type="OMA" id="MTFFIAK"/>
    <dbReference type="PhylomeDB" id="A0A068UQK1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000108">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase S.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000051">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase V.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000112">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655130" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="351"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="685" mass="75556" checksum="C68F2BAB2052C5BA" modified="2014-10-01" version="1">MSSKLLTAILANFLVVHIGAGAAVSDDFGFIYQGFQSSNLSLDGLATVTKNGLLRITNTTKLQTGHAFYPNPLKFKTKSNGSAFSFSTQFVFAIVAEVPGMPGPGMAFVIAPTRGLAEGPSTRFLGLFNTSTDGNRTNHVFAVELDTIQNPDFVDINDNHVGIDINSMTSKVSQPASYQANNKNLFDNLTLSSGQEMQLWVEYDGVARRIDVTLAPVAASKPHTPLLSLTYDLSPIFQQSMYVGFSAATSPRDIGSSHFILGWSFRMNGVAQALDLSRLPKLPRYGHKKVSEIFTVGLPLICMLFLLILISGVAYYRSRKWKFAEVLEEWELAYGPHRFKYKDLYIATKGFREKEMLGEGGFGRVYKGVLPTSKVEVAIKKVSHQARQGMREFIAEIVSIGRLRHRNLVPLLGYCRRKGELLLVYEFMSNGSLDKFLYNQPKYILSWSQRLRVIKGVASGLFYLHEEWEQVVIHRDVKASNVLLDSELNGRLGDFGLARLYDHGTLPQSTHVAGSLGYLAPEHSRTGRATTSTDVYAFGAFLLEVACGRRPIEPQAAPEEVILVDWVFSCWKAGNILQAVDQKLGTEFVKEEADSVLKLGLLCSHSEPKIRPSMRQILLYLEGSVALPDLSSLAMGVSAVGLGFAHPAGFEDILSSFAFSTDKRFSHSVADPTLSGGRQLRCSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQZ1</accession>
    <name>A0A068UQZ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00031969001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQZ1"/>
    <dbReference type="STRING" id="49390.A0A068UQZ1"/>
    <dbReference type="Gramene" id="CDP10975">
        <property type="protein sequence ID" value="CDP10975"/>
        <property type="gene ID" value="GSCOC_T00031969001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQZ1"/>
    <dbReference type="OMA" id="DFAMGTM"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQZ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF76">
        <property type="entry name" value="AUXILIN-RELATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58972" checksum="0BF375005318CB78" modified="2014-10-01" version="1">MDEFGVLVESIGFKSQRNSAPMAHLKSKPKTNLSVNDGFPDISSANASRSSFYDNNDYFVDDLDGIFQSNRNNYSSSKKSQNFFDGGDDIFDGGSFLNSKPQKGIIDFDSVFDLKNSNSKSSSNFHGDDLLTSGPRKGDALDDFFGNLKKGGEEKGSQYDDLIPGFEGTSPSRSNDPGNTRMASKPKVSQPSSGYSSKSSSAADDPFLVFESSRSEENTSSWPFSDLLEQTAGKSSVESSLDEFEKFARGMPPGDAHDKPSGKAVRNIKISLKKKEDKARDNASGRDVNTDAKVVHEKRRGKEKDRADKDKVTNGKKESVGINIFGVDTLSNVNGPRSQLKDPDLDALFNEKREPEVKETSIQGSSRTSKDFDGLSSLFEGPEFQEIEGETVERRSRRLNQHIKIQERMFKALEEKTQRDLEAQYEQEERHRLADCLDNDIKRWSAGKENNLRALLSSLQDVLWPESGWQPVSLADLITSVSVIKVYKKASMCFHPDKVQQRGCNLQQKYIAEKVFDVLKEARSNFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR16</accession>
    <name>A0A068UR16_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Beta-amyrin 28-oxidase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031518001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR16"/>
    <dbReference type="STRING" id="49390.A0A068UR16"/>
    <dbReference type="Gramene" id="CDP10717">
        <property type="protein sequence ID" value="CDP10717"/>
        <property type="gene ID" value="GSCOC_T00031518001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR16"/>
    <dbReference type="OMA" id="HTTHKNQ"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000022">
        <property type="entry name" value="Taxadiene 5-alpha hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF53">
        <property type="entry name" value="BETA-AMYRIN 28-OXIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54184" checksum="821677669256A09F" modified="2014-10-01" version="1">MEDFLCYSLYTILALLVPLYLYLLTRKPKVNKSKLPPGNLGWAILGENVDFATGGPRKFIEERMSKYSSQVFKTSFMGEKVAVFCGPAGNKFLFSNEDKTVTSWLPRSMRKALLFPSYVDAPLKEVGALQHSFLHEILKPEALKKYIPAMDAMARKHLDAEWARFQEVKVYHLAKKYTFALACRLFLNIEDPEHVKRLSDPFACVLNGLFSIPLDFPGTAYNGAIKGGNKVREELLKIVTNRKKELMEDESSAGRDLLSRMILVKDEDGKLMNEMEICNNIVGLLVASFDTTSCAVTFVLKNLLDLPHIYEKVYQEIMEIAKSKGPDDILSWEDIQKMTYSWNVARESLRLTPPAQGSFREAKTDFDYAGFTIPKGWKTFWSVYSTHRNPKHFANPDVFDPSRFEGSGPAPFTFIPFGGGPKMCPGKEYARLEILVFMYNVVTRFKMHKLIPDEKIINLASPTPVNGLPVLLRRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US46</accession>
    <name>A0A068US46_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031182001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068US46"/>
    <dbReference type="STRING" id="49390.A0A068US46"/>
    <dbReference type="Gramene" id="CDP10453">
        <property type="protein sequence ID" value="CDP10453"/>
        <property type="gene ID" value="GSCOC_T00031182001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US46"/>
    <dbReference type="OMA" id="FSMLQNN"/>
    <dbReference type="OrthoDB" id="1076611at2759"/>
    <dbReference type="PhylomeDB" id="A0A068US46"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31923">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31923:SF9">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48960" checksum="4AF336C72AEDF091" modified="2014-10-01" version="1">MSTWLSSFSLPNPFKSDSDSDDGDRDDQDNKPSTTRHSPALASPNSASSPPSGVKQDLSALSQTFSYHLRGVAAFLAPPPASQRQNAGDFNSNYTSTTAGDGYATASPPSESETITGIRKDLEEIGGSFKSLFSSSSNIAVSGISKLATNLLQFQGDVIDEGGEGEGEGEEEDLEEQDVAGIREEVVDFAREISLRPELWTEFPLSLPNDFDMSDNQRSHAATIEDLVPSIGTLRRTCSHLSDGQFWMIYFILLLPRLNETDMDLLSTSEARSISIETLLLKLRNKSNAQVASGISETVNTPALSQEMSAIQEDKSLSEQKDASAETANTTKEREVETGKNGMRLKDEDAGVPESLDGQKRPQNEDDVSFSDLEDEDNDPSDKVSGFRRTQNGRGSSASESSEWVRLTENSGAQGGQNNPGLSTRRGKDSEGEESNDWLTVDDIDFDNLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USB4</accession>
    <name>A0A068USB4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031278001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USB4"/>
    <dbReference type="FunCoup" id="A0A068USB4">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USB4"/>
    <dbReference type="Gramene" id="CDP10523">
        <property type="protein sequence ID" value="CDP10523"/>
        <property type="gene ID" value="GSCOC_T00031278001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USB4"/>
    <dbReference type="OMA" id="IPAQTWS"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000604">
        <property type="term" value="P:negative regulation of secondary growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001006">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="658"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="933" mass="102690" checksum="7FFBECE07DB27E13" modified="2014-10-01" version="1">MEILKLKYSIPLIFPLFFVAAFAAVDPFSQALLSFKSEIIDDSNSLRDWIAPALVNSSDKILACSWSGVKCDNNSSLIIGLDLSMKNLGGALSGKQFNVFIDLLDLNLSYNSFSEQLPQSIFNLTNLRSLDISRNNFSGHFPSGISNLQNLVVLDAFSNSFSGPLPPDVSQIQPLKVLNFAGSYFRGPIPSEYGSFKKLGMLRTVTHMEIGYNVYEGSIPWQLGNMSELQYLDIAGANLSGPIPKELGNLTKLESLFLFRNQLNGMIPWEFSNIVSLQSLDLSDNLLSGTIPDSLSELKNLRLLSLMYNDLSGTVPEGIAKLPQLDTLLIWNNFFSGPLPENLGRHSKLKYVDVSTNEFVGEIPPGICAGGMLMKLILFSNNFTGGLHPSLSNCSTLVRLRVEDNSFSGELSVIFSNLSEVIYMDLSRNKFVGGITVDITEASSLQYLNVSNNPQLGGVIPEKLWSLPSLQNFSAASCSISGNIPSFDICKSMMVVDLSKNNLSGTVPESISNCKGLLAMDLSINNLSGHIPVQLATLPAISVLDMSHNSFSGPIPMQFGNSSSLKLLNVSFNDISGSIPLEKAFRMMDSSAFMGNPRLCGVPLRTCHGKGMPSGLELGSRRTQKFAWVLISCAVIVLLIVMIIFGMLHFRKGTKGEWKIVSFSGLPGFTANDVLRSFNAAEAADAVPSFPHSVCKAVLPTGITVSVKKIEWEQKRVDSMSRFINRMGNARHKNLTRLLGFVYNKHMAYLLYDYSPNGSLAEKIKMKRDWETKYKIIIGVARGLSFLHHDCFPAIPHGDLKASNIVFDETMEPQLEEYGLSSLYQLKNIELPATTNPETGEVTPSTKDQLYKDVYNFGDIILEILTNGGPRSTSKEVLLRDILDRNEISPSSSMQEEIKLVFDVALRCTSRISDRPSMENALKLLSGLKHQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USG8</accession>
    <name>A0A068USG8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PHLOEM PROTEIN 2-LIKE A9-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033337001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USG8"/>
    <dbReference type="FunCoup" id="A0A068USG8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USG8"/>
    <dbReference type="Gramene" id="CDP11227">
        <property type="protein sequence ID" value="CDP11227"/>
        <property type="gene ID" value="GSCOC_T00033337001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USG8"/>
    <dbReference type="OMA" id="NELPLYF"/>
    <dbReference type="OrthoDB" id="2107747at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USG8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278:SF2">
        <property type="entry name" value="PROTEIN PHLOEM PROTEIN 2-LIKE A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19708" checksum="3823071060F886E0" modified="2014-10-01" version="1">MSSSNPHYEADPKASRRTKENGRDVIVVKPRALNIVWGNDDRYWNVPGPRDDGKPAELLQVSWLEVAGSVDADPQKTYDVSFRVSLTPDAFGWGSYPIYIMVKRGKFGKFDWKKVYLTNCDGINRIHLTGKSVQNGRENQGSTDRKLYFGLYEVWSGKWKGGLKIHDVTIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USY2</accession>
    <name>A0A068USY2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031489001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USY2"/>
    <dbReference type="FunCoup" id="A0A068USY2">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP10693">
        <property type="protein sequence ID" value="CDP10693"/>
        <property type="gene ID" value="GSCOC_T00031489001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USY2"/>
    <dbReference type="OMA" id="CNTIAIG"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USY2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000005">
        <property type="entry name" value="Germin-like protein subfamily 1 member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Cupin type-1" evidence="12">
        <location>
            <begin position="57"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="219" mass="23366" checksum="3C38B5EFBEEA8D22" modified="2014-10-01" version="1">MALLSSLAIASDPSPLQDFCVAINDPKTAASFFNAVFVNGKICKDPKVVNANDFFFQGLNIPRSTANRQGSNVTAVNVNNLAGLNTLGVSLARLDFAPYGLNPPHTHPRATEVLFVLEGTLNVGFVTSNPPNNMKNQLFTKTLNPGDVFVFPEGLIHFQFNVGKTNAVAFAGFGSQNPGVITIANAVFGSDPLISADVLAKAFQVDKKVIDLLEAQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTE2</accession>
    <name>A0A068UTE2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00035037001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTE2"/>
    <dbReference type="STRING" id="49390.A0A068UTE2"/>
    <dbReference type="Gramene" id="CDP11795">
        <property type="protein sequence ID" value="CDP11795"/>
        <property type="gene ID" value="GSCOC_T00035037001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTE2"/>
    <dbReference type="OMA" id="REIMIEF"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTE2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000008">
        <property type="entry name" value="Syntaxin 132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF277">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="278" mass="31579" checksum="5FEE19B7A38546D3" modified="2014-10-01" version="1">MKFRPNFFIFFLFSIQEVDKQVDKLSELLKKLKEANEESKSVTKASAMKAIRKRMEKDVDEVGKIARGVKAKLEALNRDNLANRQKPGCGKGTGVDRSRTNMTNALTKKFKDLMIEFQSLRQRIDDEYREVVERRVITVTGTRPDEETINHLIETGSSEQIFQTAIQGMGRGQVLNTLEEIQERHDAVKEIERKLLDLHQIYLDMAVLVEAQGDMLDNIETQVSTAVDHVQSGTTALQNAKKLQKKSRKWMCIAIIILLIIVAIIVVGVIKPWKSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTT9</accession>
    <name>A0A068UTT9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00034138001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068UTT9"/>
    <dbReference type="FunCoup" id="A0A068UTT9">
        <property type="interactions" value="1486"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTT9"/>
    <dbReference type="Gramene" id="CDP11682">
        <property type="protein sequence ID" value="CDP11682"/>
        <property type="gene ID" value="GSCOC_T00034138001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTT9"/>
    <dbReference type="OMA" id="MAIMPMS"/>
    <dbReference type="OrthoDB" id="1642657at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTT9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044827">
        <property type="entry name" value="GBF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012900">
        <property type="entry name" value="MFMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967:SF2">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967">
        <property type="entry name" value="G-BOX-BINDING FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07777">
        <property type="entry name" value="MFMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16596">
        <property type="entry name" value="MFMR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP11682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="42632" checksum="B21EFF44AD2629CB" modified="2014-10-01" version="1">MGSSEMDKSSKEAKEAKESKTPPQEQPSAPSTGTPDWSGFQAYSPMPPHGFLASSPQAHPYMWGVQHLMPPYGTPPHPYVAMYPPGGIYAHPSIPPGSYPFSPFAMASPNGVAEASGNTPGNTEVDGKPSEGKEKLPIKRSKGSLGSLNMITGRNNEPGKTAGASANGAYSKSGESASDGSSEGSDANSQNESQMKSGQRQDSAETSQNGSAAHGSQNGGPNTPHSMVNSVPMLPISAPGAPGGLSGPTTNLNIGMDYWGSAASPTVPAMRGKVPTAPVAGGMVTGGRDGVQSQLWIQDERELKRQRRKQSNRESARRSRLRKQAECDELAQRADALKEENASLRAEVNRIRSEYDQLLAQNASLKERLGEVPGPDDPRSSRNEQHAGNDAQHSGQAEPLQRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUA8</accession>
    <name>A0A068UUA8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NPH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035105001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="CDP11839">
        <property type="protein sequence ID" value="CDP11839"/>
        <property type="gene ID" value="GSCOC_T00035105001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUA8"/>
    <dbReference type="OMA" id="LDEMPQW"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUA8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043454">
        <property type="entry name" value="NPH3/RPT2-like"/>
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    <dbReference type="InterPro" id="IPR027356">
        <property type="entry name" value="NPH3_dom"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="PANTHER" id="PTHR32370">
        <property type="entry name" value="OS12G0117600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03000">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51649">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="NPH3" evidence="6">
        <location>
            <begin position="192"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60588" checksum="210FCC20E5816DE5" modified="2014-10-01" version="1">MDVSCDLEVDVNGEEVFMVDKKVVSFYSGRINKLFSKSKGLSRTLKVIFNDFPGGAESFELMTRFCYNKGKIDISPVNVSTLYCVAHFMEMKGSDSGNPNLLEQTEKSLEEVRYWTWSELLLAVRQCQDLQPVATTSGVLKKYMDSLSGRIACSGAELSPCPSTSSPESSGFRLSSDTRSTESLKNSSFKGTWWFEDFVALDPSLIEMLVKSMLSKNVDHSIVSKFLFYYQKSRFAAVATSEEKCKITEAVVQMLHTLDPALVSFKSLFGLLRIALNVNKSKCCRNQLETLIGSQLDQATLDNLLIPSPAGTKYLYDVNLVLRLVKSFIGKGACCLPLTRLRKVATLMDLYVAEVAPDPCLKSSKFLALIKALPDSTRMSYDGIYSAIDIYLEAWLSEEEKLTVCSGLNYEKLSSEACSHLTKNKRFPSRSAVQALISQKCKLKSLLHETNRPCSFTESPSSLVEAKGKAKKDESCQQIVLYAGKLDISTENERLRAHLQGMQWRVLELEKVCRKMQIQMAKMMRSKLSAQSNAKSLPRLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV61</accession>
    <name>A0A068UV61_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033817001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV61"/>
    <dbReference type="STRING" id="49390.A0A068UV61"/>
    <dbReference type="Gramene" id="CDP11523">
        <property type="protein sequence ID" value="CDP11523"/>
        <property type="gene ID" value="GSCOC_T00033817001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV61"/>
    <dbReference type="OMA" id="RHVVKCA"/>
    <dbReference type="OrthoDB" id="1933536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38353">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38353:SF2">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="204" mass="23774" checksum="A073AE15EA848E5B" modified="2014-10-01" version="1">MEDYLQYMRTLRTQMTEVEDQAAKQSAQQQIHLTTIRNLERDLDFVKNETKRVKEEKDRIMKEKGLICSQILEKQRKITSLELDSSTLNQTLDLMQHERVTQSTKLLEKSSYYTKVADDIITELKDQQGWIIANKCSFLDTENGLVGNNITREICETEESQGNIMKSLLMKFDAAKAELDQMVQMKYNLVLENSKVNICNFGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV87</accession>
    <name>A0A068UV87_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035582001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV87"/>
    <dbReference type="Gramene" id="CDP12177">
        <property type="protein sequence ID" value="CDP12177"/>
        <property type="gene ID" value="GSCOC_T00035582001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658280" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="65" mass="7358" checksum="972768548E771CB2" modified="2014-10-01" version="1">MREGSGACEQFFHLLLTLLARLEFAAGEMLKKKEEVPWSSSMKPSTIPPLFSKHVHSDILVSRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVX1</accession>
    <name>A0A068UVX1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034226001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVX1"/>
    <dbReference type="STRING" id="49390.A0A068UVX1"/>
    <dbReference type="Gramene" id="CDP11743">
        <property type="protein sequence ID" value="CDP11743"/>
        <property type="gene ID" value="GSCOC_T00034226001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVX1"/>
    <dbReference type="PhylomeDB" id="A0A068UVX1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="82" mass="8831" checksum="8514515B0B698344" modified="2014-10-01" version="1">MVQLEYMMPIASGSIAEILITYAFHIHPIQEQIGMSDGAVHVIEPLDTEPKRGSLSSQDNGTLPTNPSSSALNSQPSETPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX22</accession>
    <name>A0A068UX22_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00037447001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX22"/>
    <dbReference type="Gramene" id="CDP12794">
        <property type="protein sequence ID" value="CDP12794"/>
        <property type="gene ID" value="GSCOC_T00037447001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX22"/>
    <dbReference type="OMA" id="ESTPIFF"/>
    <dbReference type="OrthoDB" id="1728340at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="78"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="343" mass="37582" checksum="3BBCC5E8EBC162CF" modified="2014-10-01" version="1">MFNLIPGFTLVLALIFRLEKLDVRNSAGKAKVLGTVLGSGGAMILTFVKGKKIKILSQHVDIIPLHNHASVPSNNVVGSLLALLSCLSIAIWLVIQTKMSHSYPCYSSTAVMCFTGSILTGVLAICTERELSSWMLGWDCRLLAVAYLGIVSSGLCVAAVFWSSMMKGPLFVSSFSPLGLVFTALAGSLFLKEELCLGSLIGSIIITIGLCFVIWGKGKEATASQDGETESRRDEVTDGSQAAPPIVPGQCTDYLTNGVHQQFKHEHHFLLKPWFAISADTDTYRLSRIWNGRDRYDIHPRIADITIFATTRSDSADIDRFESVIHDISRYIRVNSESTPIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX42</accession>
    <name>A0A068UX42_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GSCOC_T00037543001</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UX42">
        <property type="interactions" value="1351"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UX42"/>
    <dbReference type="Gramene" id="CDP12867">
        <property type="protein sequence ID" value="CDP12867"/>
        <property type="gene ID" value="GSCOC_T00037543001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX42"/>
    <dbReference type="OMA" id="GWVKLHA"/>
    <dbReference type="OrthoDB" id="1371922at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX42"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009729">
        <property type="term" value="P:detection of brassinosteroid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000291">
        <property type="entry name" value="Brassinosteroid LRR receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.310:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase BRI1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000150">
        <property type="entry name" value="serine/threonine-protein kinase BRI1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045381">
        <property type="entry name" value="BRI1_island_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF800">
        <property type="entry name" value="OS11G0197000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20141">
        <property type="entry name" value="Island"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="1011"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1040"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDP12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1325" mass="144564" checksum="FF2BB95D8B2CBC38" modified="2014-10-01" version="1">MGHNITWHVSNSCVHSSLSILPQQPKAFPKSKSLPLFSLQFSTSLAPIYRHLTFLTPSFDSLSPLSISLKTPIISLSLYNGSKTAEILRGATHLTEEMKMKAENSTCTHLFFSSAKLFLLYHHLYLQHLIVFLTTIFFFLSTISPAAASSAASASGSSINGLSRDSQQLLSFKASLPNPTQLSDWLPANSPCNFTRVSCNKNSRVSSIDLSDLPLGIDFSLVSSSMIVLQSLELLVLRNTSLTGALTSLVRSQCSAFLSSVDLSENSISGPVSDILSFEVCSSIVSLNLSKNSLDPPMKEDKASTFGVQELDLSFNNISGQYVVPWLLSNQFPGLQHLSLKGNRVVVDFPALNLKNLSYLDLSMNNLSAGFPSITDCSNLEHLDLSSNKFSGDVGSSLSSCGKLSFLNLTNNLLKGAVPELPSGAGGVMQFLYLGRNGFQGVLPPYLSDLCPSLVELVLSYNNLSGNVPESFGACSVLELFDISNNTFFGELPVDTLVKMSNLKNLSLSFNNFLGSLPESLSKMVSLETLDVSSNNLSGVIPSGICQDPRNNLKVLYLQNNLLTGSIPESLSNCSKLESLDLSFNYLTGTIPSSLGSLSQLRDLIAWLNRLHGEIPQELMYLQRLENLILDFNDLIGSIPASLSNCTNLNWISLSNNQLSGEIPVSLGRLAYLAILKLGNNSLSGNIPAELGDCRSLLWLDLNTNFLNGTIPPGLSKHAGNIAAARLTGKRYVYIKNDGSKQCHGAGNLLEFGGIRQEQLDRISTRHPCNFTRVYRGITEPTFHHNGSMIFLDISHNHLEGSIPKELGFMYYLQILNLGNNNLSGPIPPELGGLKNAAILDLSYNRLNGSIPQTLTGLTLLGEVNLSNNNLSGPIPEVAPFDTFPETTFANNSGLCGYPLPRCGTNSGPGPNEHQKSHRRQASLAGSVAMGLLFSLFCIFGLIIVAIEMKKRRKKKEAALEAYMESHSNSATANSNWKLSARDALSINLATFEKPLRKLTFADLLEATNGFHNDSLIGSGGFGDVYKAQLKDGNVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKFGSLEDVLHDRKKIGLKLNWAARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGRQPTDSADFGDNNLVGWVKQHAKMRISDVFDPDLMREDPSVEIELLEHLKVACACLDDRPWKRPTMIQVMAFFKEIQAGSGIDSTSTIAADDGSFNAVEGVEMSIKEGNELNNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXR2</accession>
    <name>A0A068UXR2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATPase, vacuolar ER assembly factor, Vma12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00037805001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXR2"/>
    <dbReference type="FunCoup" id="A0A068UXR2">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13049">
        <property type="protein sequence ID" value="CDP13049"/>
        <property type="gene ID" value="GSCOC_T00037805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXR2"/>
    <dbReference type="OMA" id="RAIWCAA"/>
    <dbReference type="OrthoDB" id="2018698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXR2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23810" checksum="8312A8A6611C6EDC" modified="2014-10-01" version="1">MNGNDNSNPTAAAAAATDGSGNIGLVISTTETIRSFLMTASTDPNLPQDLRDLASSLSPHSSLSYKSLKSIWIGSDPKTRPSLFRLFSGSNFIFTSPKPREKSEELKARLRKLAEVAEKKEYEELVKDITPKKGVEEPFSSYKDQLGLGLHVAVTMFTGYLVGYAAFRALFSRNVGMSAAGGILGLVGGMLVETLLFIIRSTNQDRRPSAFVSRIKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V062</accession>
    <name>A0A068V062_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7356 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039042001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V062"/>
    <dbReference type="FunCoup" id="A0A068V062">
        <property type="interactions" value="1371"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V062"/>
    <dbReference type="Gramene" id="CDP13904">
        <property type="protein sequence ID" value="CDP13904"/>
        <property type="gene ID" value="GSCOC_T00039042001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V062"/>
    <dbReference type="OMA" id="CKSHTSE"/>
    <dbReference type="OrthoDB" id="785602at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V062"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055780">
        <property type="entry name" value="DUF7356"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34200">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34200:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24053">
        <property type="entry name" value="DUF7356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658120" description="DUF7356 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7356" evidence="3">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="313" mass="33791" checksum="059089D4735DBCD7" modified="2014-10-01" version="1">MTFLSLLYLIWAVPQRSSAASPCQARRNLALRGDKFNRKPVQEASPSPSPGPAVAKSNSGDGYFRGNPPKTEASPSPIPGPEAAKSKSVDHNIEGNEPNALETCDLNFQKCHDDVTNVTACLLPKDEDANSGLFLLVHNDGQSSVKLNVTLLPVNSSQNDVDILAHKVRKINVSSIASRSSSIVVNAGNWSCVIERGVRVPPGLPSYTAYVKPINGAYLLLATALLIGVMWACCKIGRDGRHLNGVPYQELEMGQQGSGSSRNVETLEESWDQSWDDDWDEEVTLKSPGGNHLGSRRANGVDSNGWGSDWNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0M4</accession>
    <name>A0A068V0M4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00040331001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0M4"/>
    <dbReference type="Gramene" id="CDP14107">
        <property type="protein sequence ID" value="CDP14107"/>
        <property type="gene ID" value="GSCOC_T00040331001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0M4"/>
    <dbReference type="OMA" id="QLSWNQI"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0M4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000445">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF791">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="475"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP14107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="806" mass="88178" checksum="FC2E71E01251B893" modified="2014-10-01" version="1">MEEFKGIAKAEALLKSGWWEDSGATATTISTHCQWSGIICNDAGSVTELLLPGYGIHDSLTNFSFSSFPNLVRLDLSGNGLIGAIPHQIGALSKLTHLTLSNNFMEGFIPSSIANLTTLVILDLSYNSFSGRIPPTLGLLSNLDFLDLNSNHFSGVIPPALSNLTKLSWLYIHGNPAMGGVLPEEIGRLKSLLELDLSYSGFSGSIPPSLGQLSNLRSLDLSTNHFSGTIPSALFNLTNLSQLDIHSNPAIGGFLSEEVRNLKSLIELDFSGLNLSGALPSALCGLTKLASLSGAENQIYGSIPSEIGNLKILKYLHLGSNRLNGQIPPTLGNLTTLVSLDLSSNQISGSIPLQLSDIPSLRFLDLSYNALEGKLPCELVNKFGSENFVGNPDLHHDSTLCGDHRHHPPYYIIGLGVSLVVFSLIGGLVLYIFCRTKVKKVEAELMDNKHGDIFRIWNYDGHMAYEDIIKATNDFDVSYCIGTGGYGSVYRARLPSGKVVALKKLHRLEGENPNFDKSFRNEADMLSKIRHRNIVKLFGFCLHKRCMFLIYEYMDRGSLFCILRDETEAVELDWIKRVNLIKGIASALSYLHYDCDPPIIHRDVSSNNILLNSQLEATLSDFGTARILELDSSNQTVIAGTFGYMAPELAYTMVVTEKSDVYGFGVVVLETLFGEHPQEFLSCISSQPNEPIMLKDLLDARLPPPTNPLVVRNVAVATALALDCVNANPKCRPTMQQVVNRFEEGRREPTRPLHTIAVNQLVSPPVLSLHDQTRADGTSSLSTMNEFHVDNSATLPSSNFSIHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0P0</accession>
    <name>A0A068V0P0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00040694001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739166">
        <property type="protein sequence ID" value="CDP14355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0P0"/>
    <dbReference type="FunCoup" id="A0A068V0P0">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0P0"/>
    <dbReference type="Gramene" id="CDP14355">
        <property type="protein sequence ID" value="CDP14355"/>
        <property type="gene ID" value="GSCOC_T00040694001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0P0"/>
    <dbReference type="OMA" id="QYNEREV"/>
    <dbReference type="OrthoDB" id="543442at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0P0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000108">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase S.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000051">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase V.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000112">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655400" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="345"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP14355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="672" mass="73824" checksum="B378A45C8EE777F3" modified="2014-10-01" version="1">MLILIKLILLVVSTLSGFASSQDLSITYNGFRSSNLSLDGIAEITPKGLLKLTNATRQEKGHAFFPNPVSFKDSPNASAFSFSTTFVFAILPEYPTLSGHGIAFVIAPTRGLPGALPSQYLGLFNESNTGNATNHVFAVELDTIQSSEFHDINNNHVGIDINGLTSTRAKPAGYYSDSDGKLQNLNLISGKAMQVWVDYDGTAKHINVTLAPIHATKPNQPLLSLSYDLSPVLNETMYIGFSSSTGSVLTSHCVLGWSFKMNGVAQGLDLSQLPKLPRNGPKEKSKVLTIGLPVILIVSLSIAISGIIYQVRTKKKFAEVLEDWERDYGPHRFKYKDLYIATKGFRDKELLGRGGFGRVYRGVLPSSKLEVAVKRVSHESRQGMKEFVAEIVSIGRLRHRNLVPLLGYCRRKAELLLVYEYMPNGSLDRYLYEQPKYNLNWNQRFRVIKGVASGLFYLHEGWEQIVIHRDVKASNVLLDGELNGRLGDFGLARLYDHGTDPQTTHVVGTLGYLAPEHARTGKATTGTDVYAFGAFLLEVVCGRRPIETQVPTEDAILVDWVFSCWNKGQVLEAVDSNMGLDYVREEVELVMKLGLLCSNSEPTARPSMRQVVLYLDGALALPDLCSLGISANGLSFANHEGFSDFALSYPSSMDKGSSYASSVTESLLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1Z9</accession>
    <name>A0A068V1Z9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00041050001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1Z9"/>
    <dbReference type="FunCoup" id="A0A068V1Z9">
        <property type="interactions" value="2045"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1Z9"/>
    <dbReference type="Gramene" id="CDP14534">
        <property type="protein sequence ID" value="CDP14534"/>
        <property type="gene ID" value="GSCOC_T00041050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1Z9"/>
    <dbReference type="OMA" id="WSESEVK"/>
    <dbReference type="OrthoDB" id="1931748at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1Z9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF15">
        <property type="entry name" value="OS02G0120000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="4">
        <location>
            <begin position="358"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP14534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="449" mass="50150" checksum="9FD2C72E486B12AE" modified="2014-10-01" version="1">MASAATPTRLILWKMPTPAMNRRCGPVVPVCCSLCKQGQRFLSSLATTDESSSAAHHRSLRKFVKTSSKHVALDTLSHLLSPTTAHPHLSYHLALPLYLIISQASWFSWNAKLLADVTALMYKQERFIEAEALILQALKKLPAHDRDLCNFYCHLLHSNAKHRSRKGVFDSLTSLKQLLARSSSVYVQKRAYESMISGLCEIGLPGEAENLMEEMRGVGLKPSGFEFKSLVHAYGRLGLFEDMKRSVTQMEDAGVELDTVCSNMVLSSLGSHKVFSEMVSWLRRMKDSEVSFSIRTYNSVLNSCPTLILLLQDPKTIPLSMEDLMGNLSQEEADLVRELVASSVLDEAMECNSAELKLDLHGMHLSTSCLIFLQWIDRLRLRFSAGDNMVPTQITVVCGSGKHSASRGESPVKGLLREMILRIKCPLRIDRRNLGCFVAKGKVFSDWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2M6</accession>
    <name>A0A068V2M6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00042399001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739176">
        <property type="protein sequence ID" value="CDP14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2M6"/>
    <dbReference type="FunCoup" id="A0A068V2M6">
        <property type="interactions" value="3462"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2M6"/>
    <dbReference type="Gramene" id="CDP14911">
        <property type="protein sequence ID" value="CDP14911"/>
        <property type="gene ID" value="GSCOC_T00042399001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2M6"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2M6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000246">
        <property type="entry name" value="Transportin MOS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="6">
        <location>
            <begin position="98"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="108351" checksum="44E86DB46C657E19" modified="2014-10-01" version="1">MELQNTVTEALNALYHHPDDAVRMQADRWLQNFQRTIDAWQVADNLLHDTASNQETLIFCSQTLRSKVQRDFEELPSEAFRPLRDSLNTLLKTFHKGPPKVRTQISLAVAALAVHVPADDWGDGGIVNWIMDEINSHPEYLPSFLELLRVLPEEAFNYKISARPDRRRQFEKELASAMEVALSILTACLNFNEFKEQILEAFASWLRLRHRIPASMLASNPLVLTALSSLTSDVLSEASVNVISELIHYTAARYSDGVSSQLPLIQVIVPQVMNLKPQLRDPSKDEEDVKAIARLFADMGDSYVELIATGSDESMLIVHALLEVASHPEFDIASMTFNFWHNLQMILTDREFFISSGNEASIEAERSRRLQIFHPSYESLVALVIFKVQYPADYAELSREDQKDFKQTRYAVADVLIDGALVLGGEATLKILYMKLVEALSCCGKDSSTDWRPAEAALYCIRAISDFVSVVESEIMPQIMSLFPKLPHQPQLLQTVCLTIGAYSKWLDASSSGLSFLPSVIDILVSGMSISEDTAAAASLAFRHICDDCCKKLCGSLDGLFQIYQRAVLGESTFKVSAEDSLHLVEALSKVITELPSEHAKKALEALCLPAVAPLQAGFLYEIYEIISQGPLVLGQKTARELTVHIDRLANIFRHVNHPEAVADTIHRLWPLFKAIFDLRAWDMRTMESLCRACKNAVRTSKRFMGVTVGAILEEIQGLYKQHHQPCFLYLSSEVIKIFGSDPTCANYLKILIECLFSQTTCLLTRIQEFTSRPDIADDCFLLASRCIRYCPQLFFPSPIFPPLVDCSMVGMTIQHREASNSILNFLSDIFDISKSSQGEIYLPIRDNVIVPRGPSITRILVACLTGALPNSQVETVTYALLALSRAYGVKTLEWAKETVSLIPSTAVTELERSKFLQALSNAQLGKDVNDLKLPIEELSEVCRRNRTVQEIVQGALRPLELHIVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2M8</accession>
    <name>A0A068V2M8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenine/guanine permease AZG2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00042600001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2M8"/>
    <dbReference type="FunCoup" id="A0A068V2M8">
        <property type="interactions" value="5"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP15055">
        <property type="protein sequence ID" value="CDP15055"/>
        <property type="gene ID" value="GSCOC_T00042600001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2M8"/>
    <dbReference type="OMA" id="AYCTDAF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2M8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF13">
        <property type="entry name" value="ADENINE_GUANINE PERMEASE AZG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP15055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="57323" checksum="43B615A8BC7EB5D1" modified="2014-10-01" version="1">MGGELCGAVGKGICKSWKKILKGLDESVSKSRVGKYFKLDARKSCFTKEVRAGTATFLTMAYIISVNATILSESGATCTVADCTVPANQTVATPDCMLKPNAGYESCLAKAKSDLVVATALSSMIGSFAMGLLANLPLALAPGMGPNAYLAYTLVGFHGSGSISYKTAMAVVLVEGCAFLAIAVFGLRARLARHIPQPVRLACAAGIGLFIAFVGLQAHQGVGLVGPDPNTLVTTAACASTDPVTGKCIGGKMRSPTFWLGSVGFIITCYGLMREIKGSMIYGILFVTLISWIRGTSVTFFPNTPQGDTNYQYFKKVVDFHTIKSTAGAISFTNFNRGEVWVALVTLLYVDVLATTGTLYTMAEVGGFVDEEGEFEGEYLAYMVDAGSTIVGSALGVPPIATYIESSAGLREGGRTGITALVVGFYFALSLFFTPLFTSVPPWAVGPSLVMVGVMMMKVVKDIDWNNIKEAVPAFVTMLLMPLTYSISNGIIAGVGLHIVLGLYDHVVGWIRWLIKMRTMVVKEQNQVSAAAAEQNLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2V8</accession>
    <name>A0A068V2V8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042305001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739176">
        <property type="protein sequence ID" value="CDP14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2V8"/>
    <dbReference type="STRING" id="49390.A0A068V2V8"/>
    <dbReference type="Gramene" id="CDP14839">
        <property type="protein sequence ID" value="CDP14839"/>
        <property type="gene ID" value="GSCOC_T00042305001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2V8"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2V8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="9940" checksum="3E95E2562A43D860" modified="2014-10-01" version="1">MRDFKRLQQDPPAGISGAPQDNNIMLWNAVIFGPDDTPWDGGSKARGYSEILLQLIFPYKVKCYPASEATMFAPQMYFSDVRLLLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3C7</accession>
    <name>A0A068V3C7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042738001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patatin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739179">
        <property type="protein sequence ID" value="CDP15146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3C7"/>
    <dbReference type="STRING" id="49390.A0A068V3C7"/>
    <dbReference type="Gramene" id="CDP15146">
        <property type="protein sequence ID" value="CDP15146"/>
        <property type="gene ID" value="GSCOC_T00042738001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3C7"/>
    <dbReference type="PhylomeDB" id="A0A068V3C7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32241:SF12">
        <property type="entry name" value="OS03G0784100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32241">
        <property type="entry name" value="PATATIN-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="85" mass="8744" checksum="B76FDC6C32B1230D" modified="2014-10-01" version="1">MAEVCGATTASRAVGLRSTDGRKKMGAIGGGVAMSNPTAAAITHVLNNKQEFCKGVEDLIMVSLGNGEMDCAVGNHWNSSPAEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4T9</accession>
    <name>A0A068V4T9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015408001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4T9"/>
    <dbReference type="STRING" id="49390.A0A068V4T9"/>
    <dbReference type="Gramene" id="CDP15539">
        <property type="protein sequence ID" value="CDP15539"/>
        <property type="gene ID" value="GSCOC_T00015408001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4T9"/>
    <dbReference type="OMA" id="FICQGCD"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4T9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="130" mass="13764" checksum="60813B5B61B4227F" modified="2014-10-01" version="1">MQSLFLRASKGAAGPCTSGDRPSTVISSFICQGCDFTTGNGTRGELIYGSKFEDANFIKKHTGPGVLSMANAGPSTNGSQFFICTEKTAWLDGRHVVFGRVTKGMDVVKAVEKVGSSFGKTSTTLLSIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V582</accession>
    <name>A0A068V582_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00016875001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V582"/>
    <dbReference type="Gramene" id="CDP15950">
        <property type="protein sequence ID" value="CDP15950"/>
        <property type="gene ID" value="GSCOC_T00016875001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V582"/>
    <dbReference type="OMA" id="DISIYIR"/>
    <dbReference type="OrthoDB" id="912170at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V582"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214:SF8">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214">
        <property type="entry name" value="ZINC FINGER, RING-CH-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP15950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="23449" checksum="AD6F960404487E25" modified="2014-10-01" version="1">MEPPELVDHAQSTQNCFPKSSVNIGVEASTAGGEPRVEDDNDDSRMLSTNDSGSPEGTSLGGGREDKRPKEESDSHADDVKIDEEHLRAEQICRICHLGNEPSSSGSSELIQLGCHCRGELGISHRSCAETWFQQRGNRLCEICNNTAKNVRLIKDISIYIRDYHEIRPMAVAGYDSPTESPRRCKQFCNFLLACLVVGFIISTFLRARMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5V0</accession>
    <name>A0A068V5V0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00016865001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3"/>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5V0"/>
    <dbReference type="FunCoup" id="A0A068V5V0">
        <property type="interactions" value="2024"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5V0"/>
    <dbReference type="Gramene" id="CDP15942">
        <property type="protein sequence ID" value="CDP15942"/>
        <property type="gene ID" value="GSCOC_T00016865001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5V0"/>
    <dbReference type="OMA" id="RCIWGKL"/>
    <dbReference type="OrthoDB" id="271433at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5V0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070483">
        <property type="term" value="P:detection of hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP15942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="238" mass="26491" checksum="41E96F9C911DE581" modified="2014-10-01" version="1">MPAVQKLYNACKVSLMPNGPISEEALEKVRALLDKIKPSDVGLEQEAQLVRGWKGSVRGHNGVPESMPPIKYLHLHESDSFSMGIFCMPAYSIIPLHNHPGMTVLSKLLYGSLHVKSFDWIDIPGPSDPSEARPAKLVRDCEMTAPTETTVLYPTSGGNIHCFKAITPCAIFDILSPPYSSEDGRHCTYFRRSPRGDLPGSLEVDGETITHMTWLEEFQPPDNFVIRRGQYKGRVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V649</accession>
    <name>A0A068V649_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017199001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739201">
        <property type="protein sequence ID" value="CDP16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V649"/>
    <dbReference type="STRING" id="49390.A0A068V649"/>
    <dbReference type="Gramene" id="CDP16131">
        <property type="protein sequence ID" value="CDP16131"/>
        <property type="gene ID" value="GSCOC_T00017199001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V649"/>
    <dbReference type="OMA" id="MYSSETH"/>
    <dbReference type="OrthoDB" id="605328at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V649"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055290">
        <property type="entry name" value="At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056592">
        <property type="entry name" value="Beta-prop_At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546:SF117">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546">
        <property type="entry name" value="F-BOX PROTEIN INTERACTION DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24750">
        <property type="entry name" value="b-prop_At3g26010-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="468" mass="54094" checksum="0D75D3D4F9287944" modified="2014-10-01" version="1">MDTLGGDRGGDGPFRRSSTRISRAPLIKHISNSRKFSIRRSSSSSASVEQIQTSETTEIPPPFVSSSSSPLSATLIGYNEDILLQILPYLPPKSLLRFQSVSKKWLSIISNPTFRRLHLRVNPTTATSAFILFRKIKNMAPELNFISSHEDYVNPMGNIVSNLNNLFENADILGLHSCNGLLCVKFCFNYDSIEFVVYNPTTNKYRLIPRLKKIVEERLLQTSVVNIAFDPLNPAQYTLVCVITDHFESEYRFIVYSSETGFWRESVKRLDIYTEKYYFDRGVLWNGGLHWATQWGSTVCFDIDHECVRSTMPNLPALYDDSSEVCYFGDSGGELYLISVSMPRKTVFNVFSLKMDYSKWDVKHRIDLTLLSIFYPLVVDEELDPNEFGFHILHYVVDKNRGNVMVVLSMHRKIFCYDINDLTVKELANIEPKEVSYRWMETSKYLRRDASKYMWREAYQHVETLAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7Q6</accession>
    <name>A0A068V7Q6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA gyrase subunit A, chloroplastic/mitochondrial</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00018907001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="HG739215">
        <property type="protein sequence ID" value="CDP16534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7Q6"/>
    <dbReference type="FunCoup" id="A0A068V7Q6">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7Q6"/>
    <dbReference type="Gramene" id="CDP16534">
        <property type="protein sequence ID" value="CDP16534"/>
        <property type="gene ID" value="GSCOC_T00018907001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7Q6"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7Q6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01063">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004043">
        <property type="entry name" value="PRK05560.1"/>
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    </dbReference>
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        <property type="entry name" value="PRK05561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="GyrA/ParC C-terminal domain-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="13">
        <location>
            <begin position="120"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP16534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="937" mass="103014" checksum="EEACEF16C52C05D2" modified="2014-10-01" version="1">MAFNITTTGLRLLRCYSQHLRPVTAQFSGLRKVRVSELRFLSSSVPIEKLPVVKAKRREAEDAVLDDGGGDNGSVVLAARDKIGGGSGGGEGRIIVSELHKEATEAYMAYAMSVLLGRALPDVRDGLKPVHRRILFAMHELGLSSRKPHKKCARVVGEVLGKYHPHGDTAVYDSLVRMAQDFSLRSPLIRGHGNFGSIDADPPAAMRYTECRLEALAEAMLLADLDQDTVDFVPNFDNSQKEPSLLPARIPNLLLNGASGIAVGMATNIPPHNLAELVDALSVLIHNPEATLQELLEYMPGPDFPTGGTIMGNIGILAAYRTGRGRVIVRGKTDVETLDSKTKRTAIIIKEIPYQTNKASLIENIAQLVENKKLEGISDIRDESDRSGMRIVIELKRGSAPSIVLNNLYRMTALQSSFNCNMVGILNGQPKVMGLKELLQAFLDFRCSVIERRARFKLSHAQDRNHIVEGIIVGLDNLDGVIDIIRKASSHSGATAQLMKEFNLSEKQAEAILDISLRRLTLLERNKFVDERKSLTEQISKLLELLSSKKRILQLIEEEAMEIKNKFSTPRRSMLEDSESGQVEDIDVIPNEEMLLAISEKGYVKRMKPDTFNLQKRGTIGKSVGKLRDNDTLSDFLVCRAHDHVLYFSDKGIVYSARAYKIPECTRAAAGVTLVQILSLSDGERITSIIPVSEFSGDQFLLMLTVNGYVKKVSLNYFSSIRSTGIIAIQLVPGDKLKWVRHCANEDFVAMASQNGMVILSSCEKIRALGRNTRGSVAMRLKGEDKVASMDIIPAALSKELDNLSHRRHCKGLTGPWLLFVSESGFGKRVPLSSFRMSPLNRTGLIGYKFASEDQLAAVFVVGFSLGDDGESDEQVVLVSQSGTVNRIKVRDISIQSRFARGVILMRLEHAGKIKSASLISAAETDSDEVEAEVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V843</accession>
    <name>A0A068V843_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00017119001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739200">
        <property type="protein sequence ID" value="CDP16093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V843"/>
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        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V843"/>
    <dbReference type="Gramene" id="CDP16093">
        <property type="protein sequence ID" value="CDP16093"/>
        <property type="gene ID" value="GSCOC_T00017119001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V843"/>
    <dbReference type="OMA" id="QFNHIQF"/>
    <dbReference type="OrthoDB" id="1889307at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V843"/>
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        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017887">
        <property type="entry name" value="TF_TCP_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005333">
        <property type="entry name" value="Transcription_factor_TCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072:SF252">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03634">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51369">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TCP" evidence="7">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="327" mass="35840" checksum="B8227393359B0525" modified="2014-10-01" version="1">MIMNSKDKAFQTKQEGDVNDSKFSKSASTSRPWAGFRNPRIVRVSRSFGGKDRHSKVCTVRGLRDRRIRLSVPTAIQLYDLQDRLGLSQPSKVVDWLIDATKSEIDKLPPLQIQAGSFSQFHQAIALSQHSSATSSNLPHFFCANPSYMKDVGAPSFLSNKQGLKINDHIHGNTNLSSFPSLLPNPLPYNPYYQWEASNLSLSQLGGHSNIPMQPEDSQSHNALSLGSSMALPSGSQLCFCPSAATIPTILPSLPPYMTASVESDPRQSNNFQFLSSSTQQVQANSLMPTLHLISSPLKSLTLNSNPKILHLQENSKNHPNKGDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9S8</accession>
    <name>A0A068V9S8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00002920001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739243">
        <property type="protein sequence ID" value="CDP17426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9S8"/>
    <dbReference type="Gramene" id="CDP17426">
        <property type="protein sequence ID" value="CDP17426"/>
        <property type="gene ID" value="GSCOC_T00002920001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9S8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="177" mass="19771" checksum="B61B4B74D4802E94" modified="2014-10-01" version="1">MDRGGGMSGSEGNMGGGSGGSGWTSFDLGVLAEENDEEVTQPNLQNAPPNPFEAVLPEPDVDDVKGLIKNRLTIYRLGNRNSAVDDWEIDRIFSLKNEILDRMIELDHSPFWNTHRNRLIRDFIQPPQGGEYRIPVLEAKLGSLFGENPASSCFYKQLIRLRDSFHIDAPFRGPRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA54</accession>
    <name>A0A068VA54_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00013194001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739256">
        <property type="protein sequence ID" value="CDP17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA54"/>
    <dbReference type="STRING" id="49390.A0A068VA54"/>
    <dbReference type="Gramene" id="CDP17660">
        <property type="protein sequence ID" value="CDP17660"/>
        <property type="gene ID" value="GSCOC_T00013194001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA54"/>
    <dbReference type="OMA" id="INFVINQ"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA54"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF243">
        <property type="entry name" value="FERULOYL COA ORTHO-HYDROXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="253" mass="28701" checksum="58E3BD0524DC9B4E" modified="2014-10-01" version="1">MAPALSMDSNSWDVISFAVDKGHGVKGLADLGLHTLPKQYIQPPEEQIINSTIVTDDSIPVIDLSNWNDPNVAEQICNAAEKWGFFQIVNHGIPIEVLENVKEATRRFFALPAEEKNKHSKDSSPSNNVRYGTSFTPKAEKALEWKDFLSLFYVSDDEAAALWPSACRNETLDFMKKSQFVIRKLLEALMKGLNVKEIDETKESLLMGSKRININYYPKCPEPELTQVLYSDYVKHFFRKAHDGKETVDFAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAR5</accession>
    <name>A0A068VAR5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00009440001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739265">
        <property type="protein sequence ID" value="CDP17821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAR5"/>
    <dbReference type="FunCoup" id="A0A068VAR5">
        <property type="interactions" value="3046"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAR5"/>
    <dbReference type="Gramene" id="CDP17821">
        <property type="protein sequence ID" value="CDP17821"/>
        <property type="gene ID" value="GSCOC_T00009440001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAR5"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="560"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="935" mass="108392" checksum="CA4E83753E7124F8" modified="2014-10-01" version="1">MCEAFASGKVVPKKDILEVIQRFNIQINNLTQFLPQDRVCEFAKLTPVQLLEETEKAVGDPRLPIQHRSLITKSQELKKLERTVESNRGSLIQLKGLNAQLERDVERVRQREELLLQVESMRKKLPWLQYDIKKAEYLEAQGWEKEAKKKLDEAANALNQHKIPLEKQKQEKTAHDANCKKLFGLLDSNTKKRLQIEKDDNSLGVQVQGTYNEIEELKLQEESRQRRVNKAKEELQAAELELDNLPVFEHPKDKIEELFAQICELDDAAREIRSAKSQKEGELNQCRQNQRQCVQRLEDMESTNHKRLQALRNSGAEKIFEAYKWVQEHRHEFRKAVYGPVLLEVNVSNRVHADYLEGHVAHYIWKAFITQDPADRDFLFTNLRSFDVPVINHVGDEVCHRRPFQVTEEMRMLGIYSRLDQIFEAPYAVREVLISQFGLEYSYIGSKETDQRADEVLRLDIMDLWTPESHYRWNQSRYGGHISASVDAVQHSHLLLCNVDVREIERLKSKRAELDDRISTLGRDIQAFQSELRHVEDKGANLHREREEINSNYQSQMRKQREVESRINQRRLRLKSMEEKENPDLSLLKLLEKIEELKVKRLQLAIQLKDSIIDAVAYRRDFAEKNLVSIELEDKMKEMEANMKQQEKLSLEASVHCQNCKKKVDDCRRELSAAKKHAESIAKITPELEQEFVKLPATVEDLEAAIHDTISQANSILFHNPNVLEQYESRQVKIDDLTRKLDEDENKLNKLLDEINSLKGSWLPTLRNLVFQINQTFSRNFQEMAVAGEVLLDEHGMDFDQYGILIKVKFRQAGQLQVLSAHHQSGGERSVSTILYLVSLQDLTNCPFRVVDEINQGMDPVNERKMFQQLVKAASQPNTPQCFLLTPKLLEGLQYSEVCTVLAIMNGPWIEQPSKVWSCGENWGSIVGLLGGSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD53</accession>
    <name>A0A068VD53_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sey1/RHD3-like three-helix bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00005122001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739253">
        <property type="protein sequence ID" value="CDP17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD53"/>
    <dbReference type="STRING" id="49390.A0A068VD53"/>
    <dbReference type="Gramene" id="CDP17613">
        <property type="protein sequence ID" value="CDP17613"/>
        <property type="gene ID" value="GSCOC_T00005122001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD53"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VD53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF20">
        <property type="entry name" value="PROTEIN ROOT HAIR DEFECTIVE 3 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658514" description="Sey1/RHD3-like three-helix bundle domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Sey1/RHD3-like three-helix bundle" evidence="4">
        <location>
            <begin position="64"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="573" mass="63460" checksum="C15F2A5B9EAC43FE" modified="2014-10-01" version="1">MWARGFETVSHICIISNLSLSLSLSVMVATVRCEEIANEKFSLLASDEDWLALEQAVHAGPVQGFGRKLSSILDAYLSEYDMEAVYFEEGVRNAKRLLLKSKALQLVHPAYITLLGHLRSSALMNFKIQLEQKLSRGEGFVASVNSCMQSSTLEFDKGCSDAVIKHADWDASKIREKLQRDMQAHASSVRAEKLSQLIAKFEKQLSARLGEPVESLFDTGGKDTWASIRRLLRREADGAVSGFSTAAAGFELDQEGFGKMVQNLRDYARSVVVKEAREQAGKAVIHMKDKFTMVFNHDNDSLPRVWTGKEDIKAITHEARSAAVSILSVLAAVRLDEKPDKIENVLSSMLIDGSVAISSRSRGAGIIGDPLASSTWEGVPPENTLISPVQCKSIWRTFTAETEYVVTQAISAREACKRSNNWLPPAWAIMAMAVLGFNEFMFLLRNPLYMLALFVIYLFGRAIWEQMDIPGEFRNGTMAGLISVASRFFPTVMILLRQLAAKAQGHPAHEPARHTQTLASQSFRSQTPTRTSTSTSTMDSSVSSNDSSETGVEYSSPQLTRRRVTNVEHEEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE42</accession>
    <name>A0A068VE42_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005587001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739372">
        <property type="protein sequence ID" value="CDP18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE42"/>
    <dbReference type="FunCoup" id="A0A068VE42">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VE42"/>
    <dbReference type="Gramene" id="CDP18809">
        <property type="protein sequence ID" value="CDP18809"/>
        <property type="gene ID" value="GSCOC_T00005587001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE42"/>
    <dbReference type="OMA" id="KRYTQWI"/>
    <dbReference type="OrthoDB" id="1937321at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VE42"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040283">
        <property type="entry name" value="DDB_G0292058-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414:SF15">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0292058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655792" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62754" checksum="79047C050C0A8C26" modified="2014-10-01" version="1">MSCLSISRRGSLLSSLVPVFLFLSSASVSFSSGEDAPLFPTSHRIPTSGAFLERNYGVVVSWRAKRFLAENSSTTTGSSGDEEPPLNSSSLVLAAKRTYRKDPLDDFNKYSGGWNIRNKHYWASVAYTAVPFFVVAGIWFLVFGLSLFLMCLYFCCCRRAPYGYSRAAYALSLILLILFTVVAIVGCIVLYVGQGKFHSSTSNTLQYVVNQADMTVGNLRNVSGYLSAAKQVQVAQVLLPGNVQTDIDQILTKIDSSANTLSERADKNSKDIRDAIAAARLALIILSAVMLLMTFLGFVFSIFGLQFLVYILVITGWIMVTGTFILCGIFLLLHNVTADTCVAMNQWVQNPTAHTSLDDILPCVDNATAQETLSKSKEVTSQLVDVLNQVITNVSNINFSPNFAPMYYNQSGPLLPLLCNPFNPDLSNRTCSAGEVDLDNATQVWGTHVCQVSPNGVCVTTGRLTPSLYGQMAAGINVSFGLYHYGPYLVSLQDCSFVRQTFSDIYTTYCPGLQRYSKWVYIGLVMVAVAVLLSLLFWVIYGRERRHRVYTKEHMPKPIEDYDRDKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEI1</accession>
    <name>A0A068VEI1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00006060001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739456">
        <property type="protein sequence ID" value="CDP19190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEI1"/>
    <dbReference type="STRING" id="49390.A0A068VEI1"/>
    <dbReference type="Gramene" id="CDP19190">
        <property type="protein sequence ID" value="CDP19190"/>
        <property type="gene ID" value="GSCOC_T00006060001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEI1"/>
    <dbReference type="OMA" id="WPQGMAV"/>
    <dbReference type="PhylomeDB" id="A0A068VEI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="54" mass="5989" checksum="25CE2516E733D868" modified="2014-10-01" version="1">MAVEDLIEMKFRLADGSDIGPSKFSPSTIVLSLKEKITSLWPKGYSLLKSTQKC</sequence>
</entry>
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    <accession>A0A068VEK6</accession>
    <name>A0A068VEK6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00007610001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739298">
        <property type="protein sequence ID" value="CDP18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEK6"/>
    <dbReference type="Gramene" id="CDP18128">
        <property type="protein sequence ID" value="CDP18128"/>
        <property type="gene ID" value="GSCOC_T00007610001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="73" mass="8149" checksum="7C0EC526F07FB8E1" modified="2014-10-01" version="1">MKAIDRKANIRTSFTVFSGFNLRKRRRHTKSLVCGVAVGLLKESLVVVTEIIIAGNNGHCLISPRTRQTRIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGR2</accession>
    <name>A0A068VGR2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate lyase 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008832001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739867">
        <property type="protein sequence ID" value="CDP19911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGR2"/>
    <dbReference type="STRING" id="49390.A0A068VGR2"/>
    <dbReference type="Gramene" id="CDP19911">
        <property type="protein sequence ID" value="CDP19911"/>
        <property type="gene ID" value="GSCOC_T00008832001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGR2"/>
    <dbReference type="OMA" id="WEFEAYG"/>
    <dbReference type="OrthoDB" id="4221926at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGR2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681:SF20">
        <property type="entry name" value="ALGINATE LYASE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658925" description="Alginate lyase 2 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="220" mass="25036" checksum="467647A8B0731641" modified="2014-10-01" version="1">MTSFSSTFLQFAILQFLLYKLLSCEGPVDPSKGFISLPFNTSFYHIQKPYDVPVDQRYKFVDGVHYLWVFSTDKPHTPTSHTKPRTEIGIQGYNYSSGVWQFEGDFYVPSGTSGVCIMQVFGATAPHATTLMLRVYNGSLFYYTDSVLVPSVYDKWFHLNVVHDVLAAKVKVFIDGCLKIVADGRGGTSHTFKCGVYAQNEDSYRMESRWKDIEILKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH38</accession>
    <name>A0A068VH38_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00008834001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDP19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH38"/>
    <dbReference type="STRING" id="49390.A0A068VH38"/>
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        <property type="protein sequence ID" value="CDP19912"/>
        <property type="gene ID" value="GSCOC_T00008834001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH38"/>
    <dbReference type="OMA" id="WITEEDC"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH38"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF103">
        <property type="entry name" value="LEUCINE-RICH RECEPTOR-LIKE KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655791" evidence="9">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="11">
        <location>
            <begin position="89"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="429" mass="47499" checksum="0718A1AE6D23850C" modified="2014-10-01" version="1">MGTVYLILKTIVAVLSCVKSSALSSSQGNLVVRCNESEKSALVKFREDCSNSMDRFSSWITEEDCCNWRGVMCSNKTGQWHVTMLDLRCHGPAESSQGDQVSDSLLDLPYLSYLDLSSNNFLQGQVPEFIGSLKNLEYLNLSNANFRGMIPDHLGNLSQLQYLDLSGNEYALRANKLEWLHGLSSLKVLELGGVDLSLVVNWLDAVNMLPSLVKLGFFACELNTLPLRPSAMNFTQLQILDLSFNKFNSPMPYWVFNISQSLSYINLSSNNLGGKLPDFSSKLNLSVLDMSKNSFVDPLPHFSLSMMSLILAENMITGTISPICESLVVNNSLSYLDLSLNALSGSIPDCWTRGNNLVVLNLAYNDISGMIPNSTGHLVHLKALILGINVLSGELPASLKYLTNYMSWILDTIIYLAKYQNGLGKIWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH69</accession>
    <name>A0A068VH69_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005533001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739414">
        <property type="protein sequence ID" value="CDP19023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH69"/>
    <dbReference type="STRING" id="49390.A0A068VH69"/>
    <dbReference type="Gramene" id="CDP19023">
        <property type="protein sequence ID" value="CDP19023"/>
        <property type="gene ID" value="GSCOC_T00005533001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH69"/>
    <dbReference type="OrthoDB" id="1930928at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="598" mass="67802" checksum="AF3F2D8A1C44E6AC" modified="2014-10-01" version="1">MSLSKFVLDSTDSITKKKSQRNKKLREQYAALSAQEKEIRLAKQREAYQRRKLNKFLALPAHEQLKQAEKSVIGETFRVHCNQAKVEDEQDRLAKKREMRRQKQREAYHKKKLRLSFGTHTSKDTEEIVDTAPATALTATMSTNCLSSEDLENLQKMESATSTADNILSAKVPSPENLQKMESVLPAANSILFAEVPSNSGLVIEKPVDTNAKETNLSQSNNNDKCKKHVTVFSSYDKGCSSNTKSSDKYICFGNSATHCLDERQLCSGCYNFLSQSLQELSEQSAPLSAIPPTTAPDNAKTSNTATQDNGQQTKSQARNSSRHCSVKRSRKKAAPAKGNTVLQGIDALNCIPHKSNKLPRKEDCQYCHAKKFHSETTNFCCSDGSIVLHDNKLPSVLVELFTAQTEEAICFRTYVRTYNNMFAFTSFGVHYDKALCKRNNGIYTFKIQGQTYHFINQLIPHHGPGMYLQLYFHDTDHELQNRMATSDRLTESLVIKIMEVMKTNPYACFFRSLRNVPQLDSYQIVLKSHTDNDQRVFNQPTASQITALWVEGENSANIYSRHIQIYTKEGYTHRIQYYYGCYDPLQYPLLFPLGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIS0</accession>
    <name>A0A068VIS0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_1309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00007809001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740393">
        <property type="protein sequence ID" value="CDP20517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIS0"/>
    <dbReference type="STRING" id="49390.A0A068VIS0"/>
    <dbReference type="Gramene" id="CDP20517">
        <property type="protein sequence ID" value="CDP20517"/>
        <property type="gene ID" value="GSCOC_T00007809001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIS0"/>
    <dbReference type="PhylomeDB" id="A0A068VIS0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF12">
        <property type="entry name" value="CYTOCHROME P450 FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="180" mass="20400" checksum="D9EE8B50022449FC" modified="2014-10-01" version="1" fragment="single">MKIGTKGDFIPCDDILKLPYINKLVEETMRLGNLSPLFSELGKGMLITKVKVHFFLISLLRDDGNLSREAYSLRVDEALDRIQNTQRMESCKLAKAHSYRITDPKNYEDALCFDPDRWNGQSNPGTFWAFGGGSRLCPGNMLARMQVAIFIHHLVSGCRWELVFANAGMRYHPHPIPVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJN6</accession>
    <name>A0A068VJN6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00008527001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG740816">
        <property type="protein sequence ID" value="CDP20779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJN6"/>
    <dbReference type="FunCoup" id="A0A068VJN6">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP20779">
        <property type="protein sequence ID" value="CDP20779"/>
        <property type="gene ID" value="GSCOC_T00008527001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJN6"/>
    <dbReference type="OMA" id="PPGEYTN"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000080">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF88">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="406" mass="45423" checksum="BC71D397BF070CF9" modified="2014-10-01" version="1">MKKAELVFVPLPGIGHFVSCVELAKLLVECDERLSITVLIMKLPFDPKVSSYTNSLVETPNLHIRYLELMKEEPSSQLSSFLSILFRFIDNHKSCVREVLAEISNSVSSHLGGIVIDMFCTSLIDVANEFGVPSYIFCPGGAATLGVLFQLQSLRDDLNEDVSHYENSDVELALPTYINPVPAKLLSSALFEKDGSVDMFLDQAKRYRKTKGIIINTFLEFESHAIHALSNDKTIPPVYAVGPLLNLKGSNSQNQETEMIKKWLDLQPECSVVFLCFGSAGSFDGDQVEEIAYALERSGYRFLWSLRRPSPKEKFEFPSEYENLDEVLPEGFLQRTAAVGKVIGWAPQAAVLSHPAVGGFVSHCGWNSILESVWCGVPVATWPLYAEQQQNAFLMVKDLQWQWRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKC9</accession>
    <name>A0A068VKC9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2935</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00008868001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742019">
        <property type="protein sequence ID" value="CDP21240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKC9"/>
    <dbReference type="Gramene" id="CDP21240">
        <property type="protein sequence ID" value="CDP21240"/>
        <property type="gene ID" value="GSCOC_T00008868001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKC9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="78" mass="9016" checksum="96B7ABEE8D97DCAD" modified="2014-10-01" version="1">MFYELSRITLRQRAFLGFLSLSSSNSAMKPAVNRGVFAPVGHQFHVLVQNFILCIKQKKSCRHEDIFEIAKEDVLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKH8</accession>
    <name>A0A068VKH8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_3390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012231001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742474">
        <property type="protein sequence ID" value="CDP21320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKH8"/>
    <dbReference type="STRING" id="49390.A0A068VKH8"/>
    <dbReference type="Gramene" id="CDP21320">
        <property type="protein sequence ID" value="CDP21320"/>
        <property type="gene ID" value="GSCOC_T00012231001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKH8"/>
    <dbReference type="OMA" id="WHALITE"/>
    <dbReference type="OrthoDB" id="1898799at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKH8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF198">
        <property type="entry name" value="RPP4C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="165"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="287" mass="32170" checksum="966C356A5E81EBCB" modified="2014-10-01" version="1">MAIQDVALSIVGPFVEKCVNPILRQFKYLIFYKCNVQTLSNEINGLGLQQAEVQRLIDAAENNAEEIKPTVTDWMKNVDDLKKEASTISQGMESVKVNCFNIVRLPNLKSRYLLGRRAAKRTDVAQKLIGEGKFDQVGYIAPLGRMSFSEQTQSSKEGLVSRMSKKKEVIEALKEDKTSLVAICGMPGVGKTFLVEQIADQVKFEKLFDEVAKANLSQIPNTRTVQDQLAEQLGLKVSEETDHARAERMYTRLSKGEKRILVILDDVREEVDFKSLGIPDRGKCKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKN3</accession>
    <name>A0A068VKN3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_999</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012371001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740083">
        <property type="protein sequence ID" value="CDP20208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKN3"/>
    <dbReference type="Gramene" id="CDP20208">
        <property type="protein sequence ID" value="CDP20208"/>
        <property type="gene ID" value="GSCOC_T00012371001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="136" mass="15900" checksum="22C0BB91E2A39725" modified="2014-10-01" version="1" fragment="single">SLLSLSLSLSFSHTHTHTLFWRELKETDVIAHFNRMVCSYFLTVVIHSMIKPYEQVEEPPFSFLYSWWDIPLHVTAQEDLILFPCVKRGLLKRFRVEYIASPSDFLSCFQTNGSTTTKKTTISYPALKKYIQLAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLB6</accession>
    <name>A0A068VLB6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00008392001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG742901">
        <property type="protein sequence ID" value="CDP21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLB6"/>
    <dbReference type="Gramene" id="CDP21394">
        <property type="protein sequence ID" value="CDP21394"/>
        <property type="gene ID" value="GSCOC_T00008392001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLB6"/>
    <dbReference type="OMA" id="YSINQER"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLB6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF16">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="323" mass="35441" checksum="13FF0F8F3D5533D1" modified="2014-10-01" version="1">MILAIAPVAVAAKESDVNLLEAEALLQSGWWGDTTTVTNVSAHCHWYGIVCNDAGSVTEILLPGYGIYDELTNLSFSSFPNLVRLDLSENGLYGTIPHQIGAPSKLAYLNLFFNEFEGELPHEIQAVELDWNKRLNLINGIANALSYLHHDCDPPIIHRDVSSNNILLNSQLKATLSDFGTAKILKPDSSNQAVIAGTYGYIAPELAYTVAVTEKSDVYSFGVVVLETLFGKHPQDFLSCISSQPNEPIMMKDLLDARLPPPTNPLVVRNVVVATALALDCVNANPKCRPTMQQVVNRFEVGRRESTRPLHTIAVNQFIKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLY4</accession>
    <name>A0A068VLY4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1518</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00006309001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740602">
        <property type="protein sequence ID" value="CDP20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLY4"/>
    <dbReference type="Gramene" id="CDP20673">
        <property type="protein sequence ID" value="CDP20673"/>
        <property type="gene ID" value="GSCOC_T00006309001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLY4"/>
    <dbReference type="PhylomeDB" id="A0A068VLY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8202" checksum="24966D53254889A3" modified="2014-10-01" version="1">MIRIHRFDYNAPSSLLNHSHSGFLSPAPSYFRSLSGLNAEGFESLDANMSAKGMRISVSTKEELGSSLERKDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNV1</accession>
    <name>A0A068VNV1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_3803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00011971001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742887">
        <property type="protein sequence ID" value="CDP21393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNV1"/>
    <dbReference type="FunCoup" id="A0A068VNV1">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VNV1"/>
    <dbReference type="Gramene" id="CDP21393">
        <property type="protein sequence ID" value="CDP21393"/>
        <property type="gene ID" value="GSCOC_T00011971001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNV1"/>
    <dbReference type="OMA" id="HLMTWQI"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNV1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15556">
        <property type="entry name" value="PHD_MMD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057765">
        <property type="entry name" value="MS1-like_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059080">
        <property type="entry name" value="WHD_PTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058054">
        <property type="entry name" value="Znf_MS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201:SF3">
        <property type="entry name" value="OS01G0877500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25565">
        <property type="entry name" value="Ubiquitin_At1g33420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25874">
        <property type="entry name" value="WHD_plant_repro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="634"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP21393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="716" mass="79992" checksum="9D66D953492127CD" modified="2014-10-01" version="1">MVVNGRPAKRLKRRVTADLNDFLTFPAASGDSSTVSASSASGPFRTCVRNFLSKHALSPPPSSLFPHLMTWQILFRVGDFTVADNDGSSPSPAVVCLDVVEEDVSRSRSIYCDQCRVVGWSSNPVCTKRYHFIIKADGNSIAGYNKTCPGCSDTLHLSEARCKSCNHVMTAEDIEDWIYNQLEDTTHLLHGVVHANGFGHLLRVNGRESGSRLLSGRHIMNFWDRLCKILGVRKVSVTDVSKKYGLEFRLLHAVTNGHPWYGDWGYEFGAGSFALTYDAYRMAVDNLSSLPLSTFLSQGRKPRTRLQDLISFYQSLSERELVNIRDLFSFLMTLIHDVHNSPSRVDGFTYKKHQSYDTRALCAWTNKDIARVEDAMFRVLRAVTGPNWVSWRALRGAVCKVGPPELLDYVLKELKGKQAAEGLVVNARRIPDSGAMEFRLEHGNIPLTVNKTLNCFPASNYPSEEHLLRDLRYLYEAMLHPQTMASYVPQAKRDVAYDSARTLLDCKQFVKDYQPEKFLLASKPYAIQLLCEVDLMEHSDEHAKNPPPELLILSSDATISDLKLEASKVFQDVYLLFKRYQAEELVGYGGVVDSTQVKLLLGPAEFVRVRGKCFGKSSLSKYRMERGVERWTVDCNCGAKDDDGERMLACDSCSVWQHTRCTGIQDSEAVPLKYVCLRCRYASQAMKTTGPCKGKTANAAVGAAGVGYGKSLANPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VPZ6</accession>
    <name>A0A068VPZ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_6772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012443001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG745856">
        <property type="protein sequence ID" value="CDP21803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VPZ6"/>
    <dbReference type="Gramene" id="CDP21803">
        <property type="protein sequence ID" value="CDP21803"/>
        <property type="gene ID" value="GSCOC_T00012443001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VPZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="54" mass="6040" checksum="81AE7F3CFB118FD2" modified="2014-10-01" version="1">MATTIVRDIGTENRNTGQKNFMLLLPSSLQPFVLKVSTPFLSLIFSPTSIKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKU5</accession>
    <name>A0A068TKU5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014134001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKU5"/>
    <dbReference type="STRING" id="49390.A0A068TKU5"/>
    <dbReference type="Gramene" id="CDO96940">
        <property type="protein sequence ID" value="CDO96940"/>
        <property type="gene ID" value="GSCOC_T00014134001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKU5"/>
    <dbReference type="OMA" id="YFGFAND"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="598"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO96940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1067" mass="115139" checksum="9880CA5B04AA904B" modified="2014-10-01" version="1">MDAKRQFSLPLKLILFCILGTTGICVSLSSTNIINRQAQFVEDEDFKIEEASIPDIQRAFASKKLTSRQLVDFYLNQIHTLNPVLRGVIEVNPEARDQADEADRIRDSINCNASYSTSLLSDMHGIPVLLKDSINTYDKLNTSAGSYALLGSKVARDAGVVERLRKAGAVILGKSSMSEWYQLRDPRLPSGWCARSGQGLNPYVQGGDPCGSSSGSAISVAANMVAVSLGTETDGSILCPADSNSVVGFKPTVGLTSRAGVIPVSPRQDTIGPICRTVSDAVYVLDAIVGFDPRDHGATKAATKFIPVAGYKQFLNKDGLKGKKLGVLRNPFVNLSNRSNAVPILESHLRTLSQQGATIIDDLEISNIGVILDPFQSGETVAMLAEFKLSLNDYLQGLTESPVRSLGDIIAFNKNNPDLESFGDFDGQDFFIVADFTNGIGEQERKAIELMEKLSGDGFEKLILENDLDAVVTLGSSAARVLAIGGYPGITVPAGYDRDGMPFGMLFAGLKGMEPKLIEIAFAFEEATMIRRPPIYRSRSIVLDNSIAIDMDIALLLFVSATIFGLSHNAEGSPFSFREAAVRDIRIALDHSRLTSRELVEFYLKQIRGLNPVLNAVIEVNPDALCLADKADRDRRAKKPGSVTGLAGIPILLKDNIATKDKLNTTAGSYALLRSVVPQDAGVVKKLRRAGAIILGKASMTEWAAYRSPGVPNGWNARRGQGVNPYHKYATSCGSSTGSATSVAANMVAVTLGTETSGSILCPSSVNSVVGIKPTVGLTSRAGVVPISPRQDSVGPICRTVSDAVYVLDAIVGFDPDDAVATKKASKYIPRGGYLQFLKSDGLEGKRLGILRCSFVGFSNSSEELNAFEPHFHILRQRGAVLVDITDTASFDSIVSSMFNDQFTAMRVEFKLALNAYLQQLITSPVRSLADVIVFNKKHTKLEKIEEYGQDNFEEAEKTNGIGRVERELLHNLTGASKIGFEKLMKDYKLDALVTPAPNIVYAISAGGYPGINVPAGYDTDGTPYGISFGGLKGSEAKLIEIAYDFEQATKIRKPPPLLRNHIKTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLY7</accession>
    <name>A0A068TLY7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00014456001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLY7"/>
    <dbReference type="STRING" id="49390.A0A068TLY7"/>
    <dbReference type="Gramene" id="CDO97191">
        <property type="protein sequence ID" value="CDO97191"/>
        <property type="gene ID" value="GSCOC_T00014456001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLY7"/>
    <dbReference type="OMA" id="HASPTRN"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLY7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000309">
        <property type="entry name" value="E3 ubiquitin-protein ligase MBR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF216">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO97191.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="544" mass="59104" checksum="0E62B2DB1D53ADB1" modified="2014-10-01" version="1">MSEIDQFATFDAGSNDVGTSSGNSGYLVRHDDGSGSSSSSWGLSCKRKVLEGNPGQSGSSGSLSMEPQDETIGRHNIPAHHNASSSLAVSATSTNSPSSNNQGQVNARIVSGMRGMTYDRFPPRVTEVAESSQRNFSFGADLGHQEPAPFDLSAAASDVRHSNAHSTNHQSRLISATESPELRTPFSRPLNLNSNSSQSPFMHVHGLARNMLPISWSGSLNSRGGASSSPILFSGERGAAVRDEANFRGSLSNNPEHPSFVAARESRHMVQEPTAWSFSPGNTGSSRNVPSSSRYTPNSGTGPLPTVWMPHQNVAAHNQQRLSEFPPWTLFPSVEPDPGGQRGNFSFLPSASSSSEEAVMASGSSSGDHNQPYSRSLLMEVSSEDINGWRALAAGIEGRHRIVSEIRQVLTAMRRAEYLRAEDYMMLDPFVNGAAELHDRHRDMRLDVDNMSYEELLALEERIGNVSTGLSDNAIFHALKHRRHQFITDESPNLEPCCICQEDYIAGDDTGTLNCGHEFHTNCIKQWLTMKNLCPICKTTALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMT6</accession>
    <name>A0A068TMT6_COFCA</name>
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        <recommendedName>
            <fullName evidence="12">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00015053001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PhylomeDB" id="A0A068TMT6"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_euk-type"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
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            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="57"/>
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        </location>
    </feature>
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        <location>
            <begin position="218"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="289"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="433"/>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO97650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="71350" checksum="06EA031B48C8DFCE" modified="2014-10-01" version="1">MKKKDAEQKWEEDPDRPTSNPLPPQSEAFADFKSSSTVSAQQLLENVAQQIPNFGTEQDKAHCPFHLKTGACRFGSRCSRVHFYPEISCTLLIKNMYNGPGLAWEHDEGLEVFVCNGIIYTKGFFFYWFHWRDFLPLYYTEEEVEHSYEEFYEDVHTEFLKFGEIVNFKVCRNGSYHLRGNVYVHYRELDSAVLARRFINGRYFAGKQVNCEFVGVTRWKVAICGEYMKSKLKTCSRGTACNFIHCFRNPGGDYEWADWEKPPPKYWVKRMAALFGYSHESGYDKWVEQETKGQRRNSSKSLTADEERYRSRRSLSREIKSSNSSPRDNYKEDKFRRSKYSKRYRSDDTKRLEVPDEREYEEERQSRSHQRGKRRQYEREFDRGWLDEEKDGDGYSYSTRNTRESSRSPFRRRSQSHDCREIDKRKIPEKISRKNHASGKRKTRGDDYSDEDEDSDTRGRREIDKDDTREHHRHNHSKHHKHNRSGRKTSKADYADKHNEDIDKRGCWEPEMVDTREYHKHNHSSRKPRKCDYAGEHHEDIDKGGHWEPEKLDTREHHERRRKSHGRSGSHDQNVDKHSRKSRSSNQKRKSYSRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN18</accession>
    <name>A0A068TN18_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014763001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN18"/>
    <dbReference type="Gramene" id="CDO97422">
        <property type="protein sequence ID" value="CDO97422"/>
        <property type="gene ID" value="GSCOC_T00014763001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN18"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="200" mass="22406" checksum="B882B5CE3C8C01D2" modified="2014-10-01" version="1">MPTWLHIIGLARFAPLSSMDNVLFPLWGKFPTSNFLYPSPAVYLASSIAVHGIMGITSNSLSLYFFSSGNFNCERRLCLLVSWSSFWVLLVCFSSRIGYGSYILLPEPCFWPQQTQQSLSLQRQQYKASPLIFLCSPFSNVISHIFCATTCSYDAKFEIKKTSFRLLSSLLAWTLSPKFWQPPTEKKKKKVGCVGGGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN52</accession>
    <name>A0A068TN52_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00014799001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Potassium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN52"/>
    <dbReference type="FunCoup" id="A0A068TN52">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN52"/>
    <dbReference type="Gramene" id="CDO97452">
        <property type="protein sequence ID" value="CDO97452"/>
        <property type="gene ID" value="GSCOC_T00014799001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN52"/>
    <dbReference type="OMA" id="IWHAVAN"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN52"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000325">
        <property type="term" value="C:plant-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF8">
        <property type="entry name" value="POTASSIUM TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="108"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="13">
        <location>
            <begin position="609"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU321113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO97452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="855" mass="94972" checksum="3B3B604B8171F65F" modified="2014-10-01" version="1">MEGSERENGGQLSSMDSESRWVFQDDEDDEEASAIGYGEGDDENDDADGLLSPRNGTMDSDDDDNDNAEQRLIRTGPRIDSFDVEALEVPGAHRNDFEDITVGRKFLLAFQTLGIVFGDVGTSPLYTFSVMFSKAPVNGNEDVLGALSLVLYTLILVPLIKYVLIVLWANDDGEGGTFALYSLICRHAKVSLLPNQLPSDARISSFRLKVPSAELERSLKIKERLETSLTLKKLLLMLVLAGTSMVIADGVVTPAMSVTSAVGGLKVGVSGIKQDEVVMISVAFLVILFSVQKYGTSKVGIVVGPTLFVWFCSLAGIGIYNLLKYDTGVLRAFNPIHIYYFFKRNSTKAWYSLGGCLLCVTGSEAMFADLCYFSVRSVQLTFVFVVLPCLLLGYLGQAAYLMENHDDTTQAFFSSVPSGAFWPVLLISNIAALIASRTMTTATFSCIKQSTALGCFPRLKIVHTSRKFMGQIYIPVMNWFLLFFSLVLVCTISSIYEIGNAYGIAELGVMMMTTILVTLVMLLIWQINIIIVLSFACIFLGLELTFFSSVLWSVGDGSWIILLFAIVIFLIMYIWNYGSKLKYETEVKQKMSMDLLRQLGPNLGTVRAPGIGLLYNELAKGIPAIFGHFLTTLPAVHSMIIFVCIKYVPVPVVPQSERFLFRRVCPKSFHIFRCVARYGYKDVRKENHQTFEQLLIESLEKFIRREAQERSLESDGDGDSDSEEEHSFSRVLIAPNGSVYSLGVPLLTEFRDASKSSAQASTSEEVKPESSSSPTLSDAEQSLEKELSFIRKAKESGVVYLLGHGDIRARKDSWFIKKLVINYFYAFLRKNCRRGIANLSVSHSHLIQVGMTYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNQ5</accession>
    <name>A0A068TNQ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00021924001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNQ5"/>
    <dbReference type="FunCoup" id="A0A068TNQ5">
        <property type="interactions" value="1616"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNQ5"/>
    <dbReference type="Gramene" id="CDO97970">
        <property type="protein sequence ID" value="CDO97970"/>
        <property type="gene ID" value="GSCOC_T00021924001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNQ5"/>
    <dbReference type="OMA" id="MGDSEGR"/>
    <dbReference type="OrthoDB" id="615826at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNQ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000225">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF2">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="11">
        <location>
            <begin position="235"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO97970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="361" mass="38456" checksum="9A29AB0C27457108" modified="2014-10-01" version="1">MEGYPGKDEGCPKLLDLIPQERQWVVKMEQDTGHGACSEEQKLELRLGPPGGPESSNLSRGCFSNSTSAGTKRGLTDTTANGNQAHVLLKPCPWSSSSANFQGKGQQLLQQQTKATPFLQLQSTSTQRPLPAEVMSKDSSQHCCSTKAVDLQNTAEKKAFSPPSAAAAATTTAVPNSSTNAQKRTAPAAVVGWPPIRSFRKIIASGSHLKSTSGSQNGISGKTANEKAVEICQKGLFVKINMDGVPIGRKVDLKAYDTYEKLSSAVDELFRGLLAAQGDSSAGGIQNKGEGEKVISGLLDGSGEYTLVYEDNEGDRMLVGDVPWHMFVSTVKRLRVLKSSEIATLCRGSKQGKLSLDVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPD1</accession>
    <name>A0A068TPD1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00022176001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPD1"/>
    <dbReference type="FunCoup" id="A0A068TPD1">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPD1"/>
    <dbReference type="Gramene" id="CDO98170">
        <property type="protein sequence ID" value="CDO98170"/>
        <property type="gene ID" value="GSCOC_T00022176001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPD1"/>
    <dbReference type="OMA" id="LHECAIL"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPD1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000060">
        <property type="entry name" value="Phox (PX) domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044588">
        <property type="entry name" value="EREX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46856">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN EREL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46856:SF3">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN EREX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="91"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="419"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO98170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="746" mass="83817" checksum="1BC8EBD0BA8AE195" modified="2014-10-01" version="1">MNMYGGHRDYSLYLFDLGATDPTLIESLALHPTRRHSFDENNKSRGSPPPKQHRHDGTSPLPLGMDWSPPPRIWEGRNSVWPHDFRTGWSYCVTVPSWTIIPKGRGLDPTVFYRVQVGIQSPEGSTTLRGILRRFSDFLKLYSDLKRAFPKKKLPPAPSKGLLRTKSKELIEERRCSLGDWIEKLLSDIDLSRSFPVAVFLELEAAARSSFYEANQSASDANSPATFFVPADQILNYSDGSLVTGSSFASDYGNDSSYEASELGTARHGMGIHHELGMGNASYEPEITSAAIASVEDGGFSVNNLRPSKKPIEGNEKGFHHNMTLIDKDTVTDHHMLKTGASQFIANNEDKMEPLSGTQNLSNARTLSGDSIESDTSSVVLERPDGSGAAQIDVLLTNSGHDVSIVLPTEEQNKMNRILNILKQRLNIARTDVEDLTARLSQELAVRQYLSTKVKDLETELETMKQTGEESLQQAIINERERVTQVQWDMEELRRKCIEMELKLKSEQEEKGLLETTKNSIVLDNDRLRQELDVAKEQVENLLKHHEESETKSKLDLKILAKEVKSLRNSQLELKQDLVRLANEKIEAERILQEERQRREHSNAANAKLLHECEVLRSRLEECSVNFLIEEEIKLSMDTSSPSEAIDILGTSDNRIGLLLAEAQLLAEDVENIVASASSSTAGRATRTRDDELRKMLTDVFIDNASLRTQINSILRYALDKSPDKSEKDAEETSSRESILSKFLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPT7</accession>
    <name>A0A068TPT7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="15">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phospholipid methyltransferase</fullName>
            <shortName evidence="15">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00022257001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="15"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPT7"/>
    <dbReference type="FunCoup" id="A0A068TPT7">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPT7"/>
    <dbReference type="Gramene" id="CDO98231">
        <property type="protein sequence ID" value="CDO98231"/>
        <property type="gene ID" value="GSCOC_T00022257001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPT7"/>
    <dbReference type="OMA" id="LYFWPLI"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPT7"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 15" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="2"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="15">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDO98231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="164" mass="18779" checksum="0A8235A49249B6BE" modified="2014-10-01" version="1">MGLLACLGVISPFPFYYWLWTQPQTWVNLCGKGSDPCKVMAMVSHFLKLVQFASLLAVSTLSWPPPFYFWPLFIFGQFLNFRVYQLLGESGTYYGVRFGKTIPWVTDFPFGVIKDPQYVGSVMSLLACLSWVPYLYILLWVLGYAFMIHLESKEDPSTRAEAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ94</accession>
    <name>A0A068TQ94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdate transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022079001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068TQ94"/>
    <dbReference type="Gramene" id="CDO98094">
        <property type="protein sequence ID" value="CDO98094"/>
        <property type="gene ID" value="GSCOC_T00022079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ94"/>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ94"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="51662" checksum="C4BC586F8687D5F1" modified="2014-10-01" version="1">MASEATDNATPLLVRPRQWWRNHCTPRSWTASVRLKTSLSSELSGAVGDLGTYIPIVLALTLVCNLDLSTTLIFTAIYNILTGLLFGIPMPVQPMKSIAAVAVSETPHLTVSQIAAAGICTASTLFILGATGLMSFIYHWIPLPVVRGVQLSQGLSFAFSAIKYIRYDQDFSTTTSSKSTSPRSWLGLDGLVLALFCLLFLILTTGDGGVPEDDEAMLRTNPDAYNRLRIRRHRRLRILSAIPAALLVFLLGFILCFIRDPSIVHEIKLGPSKIHVLKITWEDWKTGFLRGAIPQIPLSVLNSVIAVCKLSTDLFPGMDVSATGVSVSVGLMNLVGCWFGAMPCCHGAGGLAGQYRFGGRTGASVVFLGLGKLLVGLVFGNYFVKVISQFPIGILGVLLLFAGIELAMASRDMNSKEESFVMLVCAAVSLTGSSAALGFVCGIVLFLLLKLRQMDCSNFGFFKAKSVSVSTEEEDPAPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ99</accession>
    <name>A0A068TQ99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00022087001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">cv. DH200-94</strain>
        </source>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72713" checksum="3848A50AE5D30D05" modified="2014-10-01" version="1">MATDCQEDSDSENPTKRTKTQSPTPENSSPPSLFSSKGKTKLQLETNCCGICLSEAARDDNSVSRGYIDSCDHYFCFVCIMEWAKVESKCPLCKRRFSTIRRPAKPPILPADRLVHVPVRDQVYYYGGNATVGPLDPYSEVKCSVCQSSVDDSLLLLCDLCDSAAHTYCVGLGATVPEGDWFCHDCTLLRDERNKSEIDSVNNNNDGNPPSYEHVSIFDVVREPKTRCVGRSSESCLSVDQVRDLETTLGDNVNVLDSRRQTDIMQGAVQLTGRTLSRCRNVHNRIQALRDNWNSFRSGSLSFSSGKRNYRCSADRKPEIGVDSVQPSSTSSLSLKSRLDDSNPGASQNKDSPEIDRAWKMLDMAKSIEKRKSTSCQSSKFTRYKYHSSDSKQRSSENLGGFKKEQRQDCHSVWKDSNKHKPLMVERQNCHDQGFGNDGIGFAIAPLPLYYQLITSQDVRCPVQHDVPRGNGKKPYEKISLGSTFTVSDSCSRPICTGSPVEPAPVSSNLVCPSVELNFPSSCKKEPWVQKGERQKFPADSKAKENYDAKSEIQSLVKLNLKLLTKDKNLEANVFKEVARLATHTILGACGLEQPKHGIHPSQSSVCSHEKGNQHFRKSTLMPNSCRECFYVFVKDVVSAIMYERIRHVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRH0</accession>
    <name>A0A068TRH0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00022764001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRH0"/>
    <dbReference type="FunCoup" id="A0A068TRH0">
        <property type="interactions" value="2882"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRH0"/>
    <dbReference type="Gramene" id="CDO98607">
        <property type="protein sequence ID" value="CDO98607"/>
        <property type="gene ID" value="GSCOC_T00022764001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRH0"/>
    <dbReference type="OMA" id="SQPRDYQ"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRH0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000110">
        <property type="entry name" value="Argonaute 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000013">
        <property type="entry name" value="protein argonaute 10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024357">
        <property type="entry name" value="Argonaut_Gly-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12764">
        <property type="entry name" value="Gly-rich_Ago1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="7">
        <location>
            <begin position="404"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="8">
        <location>
            <begin position="693"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO98607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1069" mass="118405" checksum="E6F6F0A88DE1EF87" modified="2014-10-01" version="1">MVRKKRTELPSEGQSSSSQETGAGRGGGQPSQPVQQQQQGGFQGGGRGWGPQRGGYGGRGGGGAPRGGTAPQQYHGGPPEYQQGRGTQQYQRGGAPAQRQRSGAVGRGIPSSGGPSMAPVPELHQATPAPYQSGVTTQPMPYGRPVESQGEASSSSRAPEPSSSSVEQQFQQLSLQPEVSQAIQPASSKSMKFPQRPGKGSTGIKCIVKANHFFAELPDKDLHQYDVSINPEVTSRGVNRAVMDQLVKLYKESHLGKRLPAYDGRKSLYTAGPLPFVSKEFKITLIDEDEGNQGGAGRREREFRVVIKLAARADLHHLGMFLQGRQADAPQEALQVLDIVLRELPTTRYTPVGRSFYSPDLGRRQPLGEGLESWRGFYQSIRPTQMGLSLNIDMSSTAFIEPLPVIDFVTQLLARDVSSRPLSDADRVKIKKALRGVRVEVTHRGNMRRKYRISGLTSQATRELSFPVDERGTMKSVVEYFHETYGFVIHHTQLPCLQVGNQQRPNYLPMEVCKIVEGQRYSKRLNERQITALLKVTCQRPQERERDILQTVRHNAYADDPYAKEFGIRISEKLAQVEARILPAPRLKYHDSGREKDCLPQVGQWNMMNKKMVNGGTVNNWICVNFSRNVKDVAVRDFCHELAQMCITSGMNFNPHPVLAPMYVRPDQVERALKARFHEALTNLPPPKKELDLLIVILPDNNGSLYGDLKRICETDLGIVSQCCLTKHVFRLSKQYLANVALKINVKVGGRNTVLVDALSRRIPLVSDRPTIIFGADVTHPHPGEDSSPSIAAVVASQDWPEVTKYAGLVSAQAHRQELIQDLFKTWQDPGRGTVTGGMIKELLISFRKATGQKPQRIIFYRDGVSEGQFYQVLLYELDAIRRACASLEPNYQPPVTFVVVQKRHHTRLFASNHNDRNAVDRSGNILPGTVVDSKICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENNFSADHLQSLTNDLCYTYARCTRSVSIVPPAYYAHLAAFRARFYMEPETSDSGSVTSSAAASRGGVGPGGGARSTRAPGSNVNVRPLPALKDNVKRVMFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRY4</accession>
    <name>A0A068TRY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(6-4)DNA photolyase</fullName>
            <ecNumber evidence="6">4.1.99.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00022110001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.13" evidence="6"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRY4"/>
    <dbReference type="FunCoup" id="A0A068TRY4">
        <property type="interactions" value="1527"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRY4"/>
    <dbReference type="Gramene" id="CDO98113">
        <property type="protein sequence ID" value="CDO98113"/>
        <property type="gene ID" value="GSCOC_T00022110001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRY4"/>
    <dbReference type="OMA" id="YTVFTPY"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003914">
        <property type="term" value="F:DNA (6-4) photolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006290">
        <property type="term" value="P:pyrimidine dimer repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000004">
        <property type="entry name" value="Cryptochrome-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="10">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="298"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="396"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="9">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="9">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO98113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="538" mass="61716" checksum="022F42B941BC561D" modified="2014-10-01" version="1">MDPGSNSLMWFRKGLRIHDNPALEYAAKDSKHVYPVFVIDPRYMEPDPTAFSPGSARAGLNRIRFLLESLTDLDKSLKNLGSRLLVLKGEPSEMVIHCLKEWNISKLCFEFDTEPYYQALDDKVKSYASLVGIEIFSPVSHTLFNPAEIIQKNGGTPPLSYQSFIKVAGQPFWSSSCLSTSLSCLPPPVNLGSCTISEVPSLNDLGYKESEEDERTPIRGGESEALRRLSESIADKDWVANFEKPKGDPSAFLKPATTVLSPYLKFGCLSPRYFYQCIQEVQKNVKRHTSPPVSLLGQLLWRDFFYTVAFGTPNFDKMHGNRICKQIPWDSNDELLAAWRDARTGFPWIDAIMVQLRKWGWMHHLARHCVACFLTRGDLYVHWEKGRDVFERLLVDSDWAINNGNWLWLSCSSFFYQYNRIYSPISFGKKYDPNGNYIRHFLPVLKDMPKEYIYEPWCAPLSIQTKAKCIIGKDYPKPVVSHDSASKECRRRLAEAYELNKKLNGTVSEEDLKKLRRKLEEDTIQESKSKRLKQKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS15</accession>
    <name>A0A068TS15_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Pectinesterase</fullName>
            <ecNumber evidence="5 16">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00025765001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Secreted</location>
            <location evidence="1 16">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 16"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS15"/>
    <dbReference type="STRING" id="49390.A0A068TS15"/>
    <dbReference type="Gramene" id="CDO98832">
        <property type="protein sequence ID" value="CDO98832"/>
        <property type="gene ID" value="GSCOC_T00025765001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS15"/>
    <dbReference type="OMA" id="IPRSMIN"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS15"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6 16" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="17">
        <location>
            <begin position="50"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDO98832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="569" mass="61513" checksum="61EEE8331633E20C" modified="2014-10-01" version="1">MGSEGKKKAAILGVSSILLVAAVVGTVTYSVGRHGTETATSGGGSDQVSTSSKSVESVCKHVDYKQTCEQSLSGAKNTSDPRELIKLAFTAAVDNIASVIQNSTLLQNAAKDPRTHQALETCKYALNTSIEDLQRSFETVGTFDINKIDDYVADLKTWLSAAGTFQETCLDAFENTTGDTGEQMKKLLKTAGELTSNGLAMVTDISEVLTNFNIQGFKRRLMSSSVEPDFVDATARKLMAASTASLKPNAVVAQDGSGQFKSIMAAVNTVPKKNNQTFVIFIKAGIYKEYVTLPKHVNGIVLVGEGPTKTKITGNKNFVDGVGTFQTPTLSVNGDATILKDLGIENSAGAVKHQAVALRVSGDRTIVYNCQIDAYQDTLYTHTYRQYYRNCTISGTIDFIFGDASAVFQDCKMVVRKPMENQGCMVTAQGRKERRGIGAIVLQNCQIVADPAFLAVQPPIKAYLGRPWKEFSRTIIMQTSIDGFIAPEGWSPWMGNFGMDTCYYAEYNNRGPGADTSKRVQWKGIKKITPQIAQSFTPGAYIQGDAWITASGVPYAPGMQVDFTANLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTP6</accession>
    <name>A0A068TTP6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Omega-hydroxypalmitate O-feruloyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022851001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTP6"/>
    <dbReference type="FunCoup" id="A0A068TTP6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTP6"/>
    <dbReference type="Gramene" id="CDO98678">
        <property type="protein sequence ID" value="CDO98678"/>
        <property type="gene ID" value="GSCOC_T00022851001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTP6"/>
    <dbReference type="OMA" id="ANCNIED"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTP6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050266">
        <property type="term" value="F:rosmarinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000015">
        <property type="entry name" value="Spermidine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000008">
        <property type="entry name" value="Tryptamine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47869" checksum="23122552BF2E2CEB" modified="2014-10-01" version="1">MENGKSNTFELTVKQGQPTLIPPAEETQKGLYFLSNLDQNIAVIVRTIYCFKSGEKGNEEAVRMIKDALSKVLVQYHPLAGRLTISPEGKLIVDCTGEGAVFVEAEADCTIEDIGDNTKPDPVTLGKLVYDVPGAKNVLEIPPLAAQVTKFKCGGFVLGLCMNHCMFDGIGAMEFVNSWGEVARGLPLKVPPFMDRTILKARNPPKIEFPHHEFAEIEDTSNTAELYKEEMHYRSFCFDPEKLEKLKRKALEDGALAKCTTFEALSAFIWRSRSQALKMKPDQKTKLLFAVDGRSRFDPPIPEGYFGNGIVLTNSFCSAGELVGNPLSFAVKLVQESVQIVTDSYMRSAIDYFEATRVRPSLTATLLITTWSRLSFHTTDFGWGEPVLSGPVALPEKEVSLFLSHGRERKSINVLLGLPAAAMKTFEELMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV58</accession>
    <name>A0A068TV58_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029664001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV58"/>
    <dbReference type="Gramene" id="CDO99942">
        <property type="protein sequence ID" value="CDO99942"/>
        <property type="gene ID" value="GSCOC_T00029664001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV58"/>
    <dbReference type="OMA" id="TIRTDWV"/>
    <dbReference type="PhylomeDB" id="A0A068TV58"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="41864" checksum="4BC068776C02C582" modified="2014-10-01" version="1">MELQRVLHMSGGEGDTSYAKNSSYQVKPVLEQCIQELLRTNLPYDEKCIRVADLGCSSGPNTLLTVSDIIQSIDKVSQEMDNEFALPTIQVFLNDLFENDFNTVIKSLPSFYRKLEKENGRKIGSCLIAAMPGSFYGRLFPEQSVHFLHSSYSLHWLSQVPNGLVTESGISANKGSIYSSKASPPAIQKAYLDQFTKDFTTFLRMHSEELVSHGRILLTFMCKGDEFDGPNILDLLEVAINDLVVEGSLEEEKLDSFNVPIYAPSVEEVRHIIEEERSFEIVYLETFKLRHDAGFSIDDNQAAHVASFVRAAWEPILASHFGEAIIADLFHRFAKNAATPLRMGKGFFNNLIISLAKKPHKSETCKYLFLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVF2</accession>
    <name>A0A068TVF2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00032132001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVF2"/>
    <dbReference type="FunCoup" id="A0A068TVF2">
        <property type="interactions" value="1074"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVF2"/>
    <dbReference type="Gramene" id="CDP00250">
        <property type="protein sequence ID" value="CDP00250"/>
        <property type="gene ID" value="GSCOC_T00032132001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVF2"/>
    <dbReference type="OMA" id="MHSFWSW"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVF2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090404">
        <property type="term" value="C:pollen tube tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015247">
        <property type="term" value="F:aminophospholipid flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010183">
        <property type="term" value="P:pollen tube guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901703">
        <property type="term" value="P:protein localization involved in auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002237">
        <property type="term" value="P:response to molecule of bacterial origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000037">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000029">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1034"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="882"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="856"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP00250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138963" checksum="4680547D93ACB7FF" modified="2014-10-01" version="1">MAGWRGSRSRLGGGGDTGGMAMTEHVSSSRTVRLGRVQPQAPGHRTVFCNDREANALAKFKGNSVSTTKYDVLTFLPKGLFEQFRRVANLYFLMISILSCTPVSPVSPITNVLPLSLVLLVSLIKEAWEDWKRFQNDMAINNTPVDVLLDQKWISVPWKKLQVGDIIRVKQDGYFPADLLFLASPNPDGVCYTETANLDGETNLKIRKALEKTWDYVTPERVSEFKGEVQCEQPNNSLYTFTGNLIIQNQTLPLSPNQILLRGCSLRNTEFIVGAVIFTGHETKVMMNAMKIPSKRSTLEKKLDKLILTLFCVLFCMCLLGAVGSGIFINRKYYYLEFSKNSDAQSNPDNRFAVAALTMFTLITLYSPIIPISLYVSVEMIKFIQSTQFINNDLHMYHFESNTPALARTSNLNEELGQVEYIFSDKTGTLTRNLMEFFKCSIGGEIYGTGISEIEIGTAQRNGMKVEVQKSSDVTHEKGFNFDDARLMRGAWRNEPNPDLCKEFFRCLAICHTVLPEGEDSPEKIRYQAASPDEAALVTAAKNFGFFFFKRTPTTIYVRESHVERMGKVEDVPYEILNVLEFNSTRKRQSVVCRYSNGRLVLYCKGADTVIYERLADRDNELKRTSREHLEEFGAAGLRTLCLAYRDLSSEVYESWNEKYIQAKSSLRDREKKLDEVAELIEKELVLIGCTAIEDKLQEGVPTCIETLSKAGIKIWVLTGDKMETAINIAYACKLINNSMKQFIISSETDAVREVEDRGDQVELARFMKENVKNELKRCYEEALQYLRTGSETKLALVIDGKCLMYALDPSLRVMLLNLSLNCNAVVCCRVSPLQKAQVTSLVKKGAKRITLSIGDGANDVSMIQAAHVGVGISGQEGMQAVMASDFAIAQFRFLTDLLLVHGRWSYLRICKVVTYFFYKNLMFTLTQFWFTFHTGFSGQRFYDDWFQSLYNVIFTALPVIVLGIFEKDVSASLSKKYPELYKEGIRNTFFKWRVIAIWAFFAIYQSLVFYHFVTASSITGMNKAGKMFGLWDVSTMAFTCVVVTVNLRLLMMSNTITRWHHVTVGGSILAWFIFVFIYSGIVLPKDQENIYFVIYVLMSTIYFYLTLLLVPIAALFCDFIYQGAQRWFFPYDYQIVQEIHRHEPDASKVGLLEIGNQLTPDEARRYAIMQLPGEKSKHTGFAFDSPGYESFFASQAGVFVPQKAWDVARRASMKSRPKTSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWP7</accession>
    <name>A0A068TWP7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032310001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWP7"/>
    <dbReference type="STRING" id="49390.A0A068TWP7"/>
    <dbReference type="Gramene" id="CDP00384">
        <property type="protein sequence ID" value="CDP00384"/>
        <property type="gene ID" value="GSCOC_T00032310001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWP7"/>
    <dbReference type="OMA" id="HENNSWF"/>
    <dbReference type="PhylomeDB" id="A0A068TWP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558">
        <property type="entry name" value="CW14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558:SF40">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="326" mass="36993" checksum="E4115EA24E1EA7DE" modified="2014-10-01" version="1">MGGCISMPKKRFKSSAKYFRKPRKFRRKIASSVSVAPIEQFTGAEFGRNPSLPGSVSGNNETHASTSCRRSELPNLTLHSTQPQWDHNQVIKNGVFQEEAWFDSVSALDSDSDEDFSSVHGDFFPSLSNATEDIHMNQMAQHENNSWFGSEHRSDKNFQTIDCGKTEKFSSKVENEDENGISHSKGCYDFPSLTIADGISTEKKKIPNAPSWRFKGAKADPRQYEEKNVENHPKSHLPQLLDHCSLNSLSTSTRRRSTATKVAIKRTQQDEDETNEYCPSKRYLYHRKAGLTIPRSMGENLAHGCWHPLSPSVFKLRGENYFRHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXD3</accession>
    <name>A0A068TXD3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00032695001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXD3"/>
    <dbReference type="FunCoup" id="A0A068TXD3">
        <property type="interactions" value="2940"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXD3"/>
    <dbReference type="Gramene" id="CDP00672">
        <property type="protein sequence ID" value="CDP00672"/>
        <property type="gene ID" value="GSCOC_T00032695001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXD3"/>
    <dbReference type="OMA" id="ENFRHIS"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="834" mass="91943" checksum="0AB254134712679F" modified="2014-10-01" version="1">MGSRSDGMQQVKVERVFIGAGCNRIVNNVSWGACDLVAFGSQNAVAILCPKIAQILTTLPGHKASVNCTYWLPNAKFAYKAVEMERHYLLSGDADGVIILWEYTILDKKWRHVLQVPQPHIKGVTCISGIMMSQKDAVFASTSSDGTVNVWELVFPCTSEGDCKLSCVETLSIGSKSMVALSLAELPGNSGHLALAMGGLDNKIHLYCGQRTGKFVPACQLKGHTGWIRSLDFSLPILGIGETFILLVTSSQDKGIRIWKIAFRDSLDTKKEEISLASYIKGPMFVAGSSSYQVSMESLLIGHDDWVYSVEWQPPSIINGNECYQPQSLLSASMDKTMMIWKPEKTTGIWINVVTVGELSHCALGFYGGHWSPKADSILAHGYGGSFHLWKDVGVASDDWKPQKVPSGHFAAVSDIAWARQGEYILSGSHDQTSRIYAPWPKKSCLENEDNWHEIARPQVHGHDINCVTIIQGKGNHRFVSGAEEKVARVFEAPLSFLRTLSHATSGDSSLLDDLQAEVQILGANMSALGLSQKPIYSQVSPETTNRSNTDGLDTLETVPEAVPVEFTEPPIEEQLAWNTLWPESHKLYGHGNELYSLCCDHSGKLVASSCKAQSASVAEVWLWQVGSWKSVGRLHSHSLTVTQMEFSHDDKYLLVVSRDRHFSVFSIKDAGADEINHELMVRQEAHKRIIWACSWNPFGHEFATGSRDKTVKIWAVENASTIKQLMTLPSFKSSVTALSWVGLGRQSNHGFLAVGMESGLIELWSLSCERSDNGNLMVPNATCVVQFDPFLCHASPVSRLTWRPSEKIPDSKVIQLASCGADHCVRVFNIDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXX8</accession>
    <name>A0A068TXX8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032838001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXX8"/>
    <dbReference type="FunCoup" id="A0A068TXX8">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXX8"/>
    <dbReference type="Gramene" id="CDP00764">
        <property type="protein sequence ID" value="CDP00764"/>
        <property type="gene ID" value="GSCOC_T00032838001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXX8"/>
    <dbReference type="OMA" id="TCEPETH"/>
    <dbReference type="OrthoDB" id="758458at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXX8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044216">
        <property type="entry name" value="WDL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47067:SF6">
        <property type="entry name" value="PROTEIN WVD2-LIKE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47067">
        <property type="entry name" value="TPX2 (TARGETING PROTEIN FOR XKLP2) PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53808" checksum="7B0C32F7BE156354" modified="2014-10-01" version="1">MITRQIIKNMAGDIQEPFRLSFQADSLHSGSISFGRFETEALCWERRSSFSHNRYLEEVEKCSKPGSVTEKKAYFEAHFRRKALLSQNLSECQSGIDCQNSESAKLHNMVCEEDIENLNEHSTVTSYDDSHDHSFDSQGHSFDERELELRKYELDYSTSSFSKPESEHDNNANFEELHALSHGHSVLESDVEAAEHELDHSGTSHSKPEAGHTSDNSNVEDVVCEHVKIEETCQSGGRNSPLTTCEPETHVKQNHSGDSEATSSDMSSKTGTWLPGSPTAEQEVCSRHEVGCRSKAKLGSSQTKLAKSKLTTSQLSVVQAKKSMSSEASKCFTKRPSKSDTNASVRSRKEKQLCDSAASAMYSAPKASTCEVSQSFKTKLPENKSQSNAKESTTKKAVSSRPSTADKLAPRLSSRPSTADKIAPIISSRPSTADKAAPITHHNASRPMRSVNSSKQFIKSSASAFSFKSDERADKRKEARKILFCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY30</accession>
    <name>A0A068TY30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">At1g68980-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00034469001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY30"/>
    <dbReference type="FunCoup" id="A0A068TY30">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TY30"/>
    <dbReference type="Gramene" id="CDP00987">
        <property type="protein sequence ID" value="CDP00987"/>
        <property type="gene ID" value="GSCOC_T00034469001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY30"/>
    <dbReference type="OMA" id="AYCKEGH"/>
    <dbReference type="OrthoDB" id="726314at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057440">
        <property type="entry name" value="At1g68980-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46598">
        <property type="entry name" value="BNAC05G43320D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46598:SF1">
        <property type="entry name" value="OS10G0422566 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25245">
        <property type="entry name" value="TPR_At1g68980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="At1g68980-like TPR repeats" evidence="4">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="784" mass="88768" checksum="CBAAE3022D78D1FA" modified="2014-10-01" version="1">MISLRKLAYHTPRLSSALLQSLATGGLRTYEKFSVAEWSCRPSTLFRELKSTNLIEKSNCLDFQTGFTRSSLPFSTVAGTILVQARDPGKLCQELEVAIEELRLSDAWNLYKQYMHMEGFPRKSIVNVLVASLVESLDVQWLEKAYALFEQASEEHKQNLFEKETLIYLSLGLARCGLPVPSSTILRKLIEMEQFPPINAWATILAYMSQTSPGAYIAAELVLEIGYLFQDGRVDPRKKVNAPLIAMKPNTTAFSIALAGCLLFNSARKAEQLLDMVPRIGLKVDATLLIILAHVYENNGRTEELKKLQRQIDESYGVSDLQFLQFHNCLLSSHLKVGDLDSASQMVLEMLHRAKKARSSFGATTSAFKMVANGNRSSSGHVSKEDLDCREPDGVEYPTLRPLLSFENFSRDRKFLKLEAEAKELLDVLVFKVQRQVELISTEHGILQPTERLYVKLVKAFLESQRTKDLAEFLIKAEKEGSPVSADNSTLIHVIKSCISLGWLDQAHDLLDEMRLAGIRTGSSVYADLLKAYCKENRAGEVTSLLRDARKAGIQLDASCYEALIESQVLQKDTQGALFLFKEMKEAKIRRGGHQDFEMMVKGCSESGETDLMSKLLQEIKEGHKIDCGVHAWNNVIHFFCKKRLMQDAENAYKKMKSLGHSPNAQTFHSLVMGYAAIGTKYTEVTELWGQMKALAFSRKMKFDQELLDAVLYTFVRGGFFIRANEVVDMLERGNLFIDKYRYRTLFLKYHKTLYKGKAPKFQTESQMKRREAALNFKKWVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYN5</accession>
    <name>A0A068TYN5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00034680001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYN5"/>
    <dbReference type="FunCoup" id="A0A068TYN5">
        <property type="interactions" value="1485"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYN5"/>
    <dbReference type="Gramene" id="CDP01147">
        <property type="protein sequence ID" value="CDP01147"/>
        <property type="gene ID" value="GSCOC_T00034680001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYN5"/>
    <dbReference type="OMA" id="NIRVKPN"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYN5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368:SF4">
        <property type="entry name" value="OS10G0403700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="361" mass="39946" checksum="EDA9302C0C868D4C" modified="2014-10-01" version="1">MAEQDAVKFGILGCAEIARKVSRAIRLSPNSTLYAVGSRSVEKAAKFAKDNGFPDSAKVFGGYDAVLDDPDVDAVYIPLPTSMHVKWAVLAAQKKKHVLLEKPVALNVKELDVILEACESHGVQFMDGTMWMHHPRTAKMKEFLNDPQRFGQLKTVQTVFTFAADPEFLENDVRVKPELDALGVLGDAGWYNVRACLWAFDYELPKKVTALPGPVFNKSGVLVSCGASLYWEDGKVATFHCSFLSTLTTDVTAVGTKGYLRLHDFVIPDEEDKASFFTRENPGFAELQRGVVADRNEHVVATDLPQEVKMVMEFSRLVGIIKAEGGKPEKIWPTFSRKTQLVLDAVKTSIEKGFESVELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYU5</accession>
    <name>A0A068TYU5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00036550001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYU5"/>
    <dbReference type="Gramene" id="CDP01480">
        <property type="protein sequence ID" value="CDP01480"/>
        <property type="gene ID" value="GSCOC_T00036550001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYU5"/>
    <dbReference type="OMA" id="DENCIEW"/>
    <dbReference type="OrthoDB" id="1676282at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000027">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000065">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF774">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 85A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="491" mass="55753" checksum="6D592FD45861F9A4" modified="2014-10-01" version="1">MENRMKKPHAICIPYPVQSHISATLKLAKLLHLKGFHITFVHTEYNYNRILKARGPKSLIGAADFNFETIPDGLPPAENDDVTQDVFQLCLSTSKTCYVPFCNLLKKLNNRASMDDQFPPVSCVISDGFMSFTLEAAEELGIPNLLFWPFSALTVMCLLHYPHLRERGFTPLKDESYFTNGYMENTIDWIPGIDIIRLRDIPTIIWATDPKDEFLEWVVKIMPRTYKSSGIILNTFDTLEYDVLKQLSNMIDHVYSLGPIHLLLKDIQKSDLSAESIQSNLWKEDENCIEWLNSKKQGSVAYINFGSITVMTEDQLGEFAWGLANSMQNFLWIIRPDLVAGGQIVLPPEFAVATKDKGMLATWCNQELVLNHPSIGVFLTHCGWNSVLESLCAGVPMICWPFFADQLTNRLCCCTHWGVAVEIDSNVDRLEVEKVVRDLMEGKKGKELQQKVWEWKNKAEEAIRPSIGSSYLNLDKMIENVLQSPNTTSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZL3</accession>
    <name>A0A068TZL3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00036837001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZL3"/>
    <dbReference type="STRING" id="49390.A0A068TZL3"/>
    <dbReference type="Gramene" id="CDP01700">
        <property type="protein sequence ID" value="CDP01700"/>
        <property type="gene ID" value="GSCOC_T00036837001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZL3"/>
    <dbReference type="OMA" id="VIPCASM"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZL3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000027">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF322">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP01700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="287" mass="33238" checksum="FDE7412658B61222" modified="2014-10-01" version="1">MRKKKLILVAFPSLAVVLFIFIIFFSIRLKSPSSTATKSIIILQDTSHLESRFSLLIGILTRPDNYERRHFLRLIYGIQSSPIAKIDVKFVFCKLTKPEQRTYVALEIMRFRDIIILNCTENMNSGKTYAYFSSLPRILPQHYDYVMKADDDVFLRLVPLALSLQPLPRSDMYYGFVIPCPSMNPFVHYMSGMGFILSWDLVQWIAVSDIPANDTFGPEDKLVGKWLDMGKKATNRFSNKPAMYDYPGTNSRCSHDLIPDTIAVHRLKKWEQWFHVLSFFNVTEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZR3</accession>
    <name>A0A068TZR3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF6</name>
        <name evidence="6" type="ORF">GSCOC_T00036916001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZR3"/>
    <dbReference type="FunCoup" id="A0A068TZR3">
        <property type="interactions" value="2734"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZR3"/>
    <dbReference type="Gramene" id="CDP01760">
        <property type="protein sequence ID" value="CDP01760"/>
        <property type="gene ID" value="GSCOC_T00036916001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZR3"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZR3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="245" mass="26442" checksum="3705343E0029B45B" modified="2014-10-01" version="1">MATRLQFENSCEVGVFSKLTNAYCLVAIGGSENFYSTFEAELADVIPVVKTAIGGTRIIGRLCAGNKNGLLLPHTTTDQELQHLRNSLPDSVVVQRIDERLSALGNCIACNDHVALTHTDLDRETEEMIADVLGVEVFRQTIAGNILVGSYCAFSNRGGLVHPHTSIEDLDELSTLLQVPLVAGTVNRGSEVIAAGLTVNDWTAFCGSDTTATELSVIESVFKLREAQPSAIVDEMRKSLIDSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZZ2</accession>
    <name>A0A068TZZ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Geranylgeranyl diphosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00036720001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZZ2"/>
    <dbReference type="SMR" id="A0A068TZZ2"/>
    <dbReference type="STRING" id="49390.A0A068TZZ2"/>
    <dbReference type="Gramene" id="CDP01617">
        <property type="protein sequence ID" value="CDP01617"/>
        <property type="gene ID" value="GSCOC_T00036720001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZZ2"/>
    <dbReference type="OMA" id="LCMASCE"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZZ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000001">
        <property type="entry name" value="Geranylgeranyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053378">
        <property type="entry name" value="Prenyl_diphosphate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045485">
        <property type="entry name" value="FPPsyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281:SF1">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP01617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40002" checksum="4140DFF3F0675772" modified="2014-10-01" version="1">MAISATISSRYGGSFLQQNLDHFKISVQTIPRSQNIRMIVPKKINPASHVANSSALEAAQVQEKKPLSLDSPFPDFRFDEYMNTKAISVNKALDDAIPLQEPIKIHEAMRYSLLAGGKRVRPMLCIASCELVGGDESLAMPMACAVEMIHTMSLIHDDLPCMDNDDLRRGKPTNHKVYGEETAVLAGDALLSLAFEHVAAKTGNVEASRVVRAIAELASSVGSQGLVAGQIVDLSSEGEQVDLNHLEYIHVHKTSKLLEAAVVCGAIVGGANEAEIERMRNYAKCIGLLFQVVDDILDVTKSSEELGKTAGKDLATDKATYPKLMGLERAKKFADELVAVATEELSHFDAVKAAPLYHLANYIAYRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0A8</accession>
    <name>A0A068U0A8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonan lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036711001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0A8"/>
    <dbReference type="STRING" id="49390.A0A068U0A8"/>
    <dbReference type="Gramene" id="CDP01609">
        <property type="protein sequence ID" value="CDP01609"/>
        <property type="gene ID" value="GSCOC_T00036711001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0A8"/>
    <dbReference type="OMA" id="PENCCIY"/>
    <dbReference type="OrthoDB" id="2130367at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0A8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF6">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="170" mass="19023" checksum="211FE884728937E1" modified="2014-10-01" version="1">MKLSFLCTLKKIIIIVFTPPRNGPTIWEIGIPDRTAAEFHVPDGNPRLENPLFMNHPENCCIYHFCTSLFVLSKALSTIHLKKSVTFEVVMVNDPSASSPQFSTGLIGKDKAIARHGIHGLYQLFSICLPGHRLISGSNTIYLRQSSGEYIFNGVMYDYLRLEGPPVQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0M7</accession>
    <name>A0A068U0M7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00039379001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0M7"/>
    <dbReference type="STRING" id="49390.A0A068U0M7"/>
    <dbReference type="Gramene" id="CDP02095">
        <property type="protein sequence ID" value="CDP02095"/>
        <property type="gene ID" value="GSCOC_T00039379001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0M7"/>
    <dbReference type="OMA" id="AAMGNMF"/>
    <dbReference type="OrthoDB" id="1887762at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0M7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
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    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="3"/>
            <end position="10"/>
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        <ligand>
            <name>GTP</name>
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            <position position="10"/>
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            <begin position="105"/>
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    <sequence length="163" mass="18412" checksum="02C0388D9D149945" modified="2014-10-01" version="1">MVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSSNIASKASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0S2</accession>
    <name>A0A068U0S2_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039404001</name>
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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            <taxon>eudicotyledons</taxon>
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            <taxon>asterids</taxon>
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            <taxon>Coffea</taxon>
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    </organism>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
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                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
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        <property type="entry name" value="PROTEIN KINESIN LIGHT CHAIN-RELATED 2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
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        </location>
    </feature>
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            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="761" mass="83603" checksum="5E838E4276EE349B" modified="2014-10-01" version="1">MTGLLHASTFQPLCNPTHSSYRRTKRWPLCCFLGGLIIRRKLYERDFSGVLMIHFVMEEVSSREFTGPYVPHKEIFAQTSPRSPLSTHSPETDSIDLAIEGAVDTSIEELYNNVCEMQSSDQSPSRLSYLSYGEESRIDSELRYLAGGDYGEAEITKEKNEAGENSSEELKGFKDDTTDQPFSSGQAKNSDTPKKAGLKSKSFNGIPRGGTGRRSLKSSKKPNAMSPAKIERNSPLAGVKKQNGAEDSSEAAYLGPYVLKQARGLIASGDNLHKALELALRAMNLFETSASGKPNLEFVMCLHVVATLYCRLGRYSDAVPLLEKSIEIPVMDLGQNHSLAKFAGCMQLGDTYAMTGQIENSILFYAAGLEIQRQVLGDKDPRFGETCRYVAEAHVQAMQFDEAEKLCQMALEIHRENISPASPEEAADRRLLGLICDSKRDHEAALEHYVLASMAMAANGQEADVAAIDCNIGDAYLSLVRYDEAIFSYQKALTIFKSTKGDNHPSVASVYVRLADLHNKIGKFSECRSYCENALRIFNKPIPGSSPEEIASGLVDVSAIYESMSETDQALELLQTAIKVYGNAPGQQSTIAGIEAQIGVLYYILGSYSDSYNSLKNAITKFRAVGEKKNALFGVALNQMGLACVQLYAINEAAELFEEARSILEAECGPYHADTLGVYSNLAGTYDAMGRTVDAIEILEYVVGLREERLGTANPDVIDEKRRLAELLREAGKVRNKESRSLETLLDKHGSIITKPEITVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1C1</accession>
    <name>A0A068U1C1_COFCA</name>
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        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">GSCOC_T00039387001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1C1"/>
    <dbReference type="FunCoup" id="A0A068U1C1">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1C1"/>
    <dbReference type="Gramene" id="CDP02102">
        <property type="protein sequence ID" value="CDP02102"/>
        <property type="gene ID" value="GSCOC_T00039387001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1C1"/>
    <dbReference type="OMA" id="VGRCHQI"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1C1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000142">
        <property type="entry name" value="Universal stress protein A-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044187">
        <property type="entry name" value="At3g01520-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47710">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47710:SF1">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="25839" checksum="7B210880C484C07A" modified="2014-10-01" version="1">MESEPTRIMMGVNESTIKGYPHASISSRGAFDWALKKIIRSNTSGFKILFLHVQVPDEDGFDDMDSIFASPEDFRRMNHRNKIRGLHLLEYFVNRCHEVGVACEAWIKKGDPKEVICHEVRRVQPDFLVVGSRGLGPFQRHVCFLIIVFISQNPYPVMHIMDLMELTYESCLSSMSPSLGILVADQKPFSFCRVFVGTVSEFCVKHAECPVITIKRSAAESPQDPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1K1</accession>
    <name>A0A068U1K1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00039326001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1K1"/>
    <dbReference type="FunCoup" id="A0A068U1K1">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1K1"/>
    <dbReference type="Gramene" id="CDP02049">
        <property type="protein sequence ID" value="CDP02049"/>
        <property type="gene ID" value="GSCOC_T00039326001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1K1"/>
    <dbReference type="OMA" id="HKDEDWD"/>
    <dbReference type="OrthoDB" id="1915442at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1K1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="entry name" value="YhbY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040286">
        <property type="entry name" value="At3g25440-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31426:SF4">
        <property type="entry name" value="CRM-DOMAIN CONTAINING FACTOR CFM9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31426">
        <property type="entry name" value="GROUP II INTRON SPLICING FACTOR CRS1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="YhbY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="5">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="565" mass="64698" checksum="AA257608FC6A1BC2" modified="2014-10-01" version="1">MLAAKNLQRQSLRALSSLFFFNSSKNAVKGEGDGWTKWGGGGGGVEGSVFPVKDVCFVSMRRVWNGFDGARGLSAKSMRSKVESRMRKESGKTLREIRRAKKLRKKLMTDEERLIYNLRRAKKKVALLLQKLKKYELPELPPPCHDPELLTPEQLQAYKKIGYRNRNYVPVGVRGVFGGVVQNMHLHWKFHETVQVCCDNFPKERIKEMASMLARLSGGIVVNVHNVKTIIMFRGRNYRQPKNLIPINTLTKRKALFKARFEQALESQKLNIKKIEQELRRKGVNPDDPVAMASIQRVASTFFNAIDKKEGSPYVFQRDKKTEMVSISDLQQSQSAEDSDQEELDRFIAEIEDAADKEWAAEEAAEKEEFGKIRYWNKEDSGDRFRRSEKIGGDESDDNIRGRTQNWSSSRGRERITAASDDEDGDMSEDDGGWDSNDSQDVSNDETDCSDSGEARDRFSGHKVARRQQDKILRTSKSTSFSRNEKSKLRVEKVVKDSISDDMLSDLEDVMYESDDRERQNVMKSRAPGYNYQSSTDEDDYDHTRTGNKDGIGRIKKLDETWDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U285</accession>
    <name>A0A068U285_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039820001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U285"/>
    <dbReference type="FunCoup" id="A0A068U285">
        <property type="interactions" value="2732"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U285"/>
    <dbReference type="Gramene" id="CDP02442">
        <property type="protein sequence ID" value="CDP02442"/>
        <property type="gene ID" value="GSCOC_T00039820001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U285"/>
    <dbReference type="OMA" id="HEGKLMI"/>
    <dbReference type="OrthoDB" id="1688597at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U285"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050655">
        <property type="entry name" value="Plant_B3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31920">
        <property type="entry name" value="B3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31920:SF108">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR VRN1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="267"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="41671" checksum="4E10114B9C455CE3" modified="2014-10-01" version="1">MATGQRGKKGSHQTTNNPAKNPPHFFKVVLSSVGQGIRIPTAFMREHGESLKKVVWLKVPTGASWPVALLQTDVGTWLRKGWREFAEYYTIDRSYFLVFRYEGNSQFYVIIFDPTASEIEYPVEAGKEQGVHDNDLDQLPRRRTNPVQIFDEIESDDDSIEILEEIPAAASSSHAHNRRKSAQVDGNRQYPMESGHHGMHDRQGQLPRRTSLVRKPEEIYSDDDDDDESIEIVEEISAPCKGRSALKKSTSIAYQRAKAFKSKCPFFIVFMQPSYVSGSFTVNIPLTFVRDYLTTTQSHLDWELRLSEGKKKWSARCTFHSRNAKIYRGWKEFVVENNLVTGDVCVFELVMGAKIFNVTVYRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U290</accession>
    <name>A0A068U290_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00040090001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U290"/>
    <dbReference type="FunCoup" id="A0A068U290">
        <property type="interactions" value="2944"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U290"/>
    <dbReference type="Gramene" id="CDP02636">
        <property type="protein sequence ID" value="CDP02636"/>
        <property type="gene ID" value="GSCOC_T00040090001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U290"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U290"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="81"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="278"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="575"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP02636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="629" mass="70556" checksum="59A6EAEB87514F60" modified="2014-10-01" version="1">MAKKKQKSSQNKDKNQELKEQPVVVEDEAEAAAAAKQEKEDEEKEEEEERSFEDLGLDPRLIRALIKKNIDKPTPIQRVAIPLILEGKDVVARAKTGSGKTFAYLLPLLQKLFSDSPSKHNQAPTAFILAPTRELCQQVYAEVMSLIELCRVQLKVVQLTSSMSNSDLRTALAGPPDILVSTPACVHTCLSDGVLQQKAVQDSLSIIVLDEADLLLSYGYEDDLKALTAHVPRRCQCLLMSATSSADVEKLKRLILHNPYILTLPEVGDLKDDIIPKNVQQFYISCTARDKLVHILALLKLELVQKKVLIFTNAIDTSYRLKLFFEQFGIKSAVLNAELPQNSRLHILEEFNAGLFDYLIATDDSQPQEKKKFDSGSNAEQKKARKHAKQKLDAEFGVVRGIDFKNVHTVLNFEMPQSAAGYVHRIGRTGRAYNTGASVSLVSPEENDMFEDIKSIIGESDNMDSNFIAPFPLLTKNAVEGLRYRAEDVARSVTKVAVRESRAQDLRNEILNSEKLKAHFQDNPRDLDLLKHDKVLSKKDPAPHLRDVPEYLLDPTTQEARKIVKLVRAAMGNNNTARRKGFKGKFRKSRDPLKTFSAEASRRPSKGGMRRRGPGCDASHKRKRKETVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3D8</accession>
    <name>A0A068U3D8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040318001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
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        <property type="protein sequence ID" value="CDP02817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068U3D8"/>
    <dbReference type="Gramene" id="CDP02817">
        <property type="protein sequence ID" value="CDP02817"/>
        <property type="gene ID" value="GSCOC_T00040318001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3D8"/>
    <dbReference type="OMA" id="NPWERNP"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000554">
        <property type="entry name" value="protein indeterminate-domain 12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protein indeterminate-domain 5, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
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    <dbReference type="InterPro" id="IPR055185">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
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    <dbReference type="InterPro" id="IPR055186">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593:SF188">
        <property type="entry name" value="ZINC FINGER PROTEIN GAI-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22992">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22996">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
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        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
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            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP02817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="502" mass="51869" checksum="8CC59FCCD0109B22" modified="2014-10-01" version="1">MNDSTASGDASASSSGNQAAAPPTSSAKKKRNLPGMPDPDAEVIALSPKTLLATNRFVCEICNKGFQRDQNLQLHRRGHNLPWKLRQRSSKEVKKRVYVCPELTCVHHDPSRALGDLTGIKKHFCRKHGEKKWKCDKCSKKYAVQSDWKAHSKICGTREYKCDCGTLFSRRDSFITHRAFCDALAEESAKAQTVEALPAPTADDEEPKLQTLASSSPPPSVAAQPPPPAALVSSALPVQNPEGPENPKQSPAPPQILEETSVVTSLTGSCGSSSSSSSHGSTSSSVFASLFASSTTSGSLQSQTPEFTDLFRAVARPENASEVVASSSTEPISLCLATSHGSSIFGTAGQERRQYAPAPQPAMSATALLQKAAQIGAAATNASLLRGFGIVSSASASSGQQEWSGRGIESDSASLAAGLGLGLPCDGGSSLKELMLGTPSVFGPKHTTLDLLGLGMAAGGGPSGGFSALMTSIGGGLDVAAAAAATFGGSGEYSGKDMGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U491</accession>
    <name>A0A068U491_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00041851001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1566"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U491"/>
    <dbReference type="Gramene" id="CDP03311">
        <property type="protein sequence ID" value="CDP03311"/>
        <property type="gene ID" value="GSCOC_T00041851001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U491"/>
    <dbReference type="OMA" id="HANRNNM"/>
    <dbReference type="OrthoDB" id="6283463at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U491"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="153"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP03311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="606" mass="66206" checksum="279A41935B28C3BF" modified="2014-10-01" version="1">MEQSEGGDFPPKNVQSETTGQQQPPPQVGTDIPPKKLARQLDFTGYTGVSSAAASSATATAALREHTQQTQPPQVAVMPSLPQPQLQQPVPRPTQPPKSQLQPQPQPPIPLMSMQQPPVPPAVHPQMRPMKPESPRPRPRSNAGDAKDGTPKKQKQCNCKHSRCLKLYCECFASGIYCDGCNCVNCFNNVENEAARREAVENTLERNPNAFRPKIASSPHGIRDSREEPGEGLVIGKHNKGCHCKKSGCLKKYCECFQANILCSENCKCMDCKNFEGSEERQALFHGDHANNIAYIQQAANAAITGAIGSSGYGSPPVNKKRKGQELFFASTVKDPLNRLGQLLLMYLQANHMKTTVPSSTLSSIPGARLGNPAGMGPSKFTYRSLLADIIQPQDLKELCSVLVVYSAEAAKMLADERNATERSSQEHRESHLASTQDQSQNQKDLSVAEKARLADSFDGNSSEKIGPDESVSDGADVSKSRPMSPGTLALMCDEQDAMFTTAASPSDLTGQSNMSCQLPHGQGLTEAYAEQERIVLTKFRDCLNKLVTLGEIKGKLIFLFSLLALRRILFSKIQAYLMNPNCLKPIKQCRHGNLSLDPRYPAEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7F8</accession>
    <name>A0A068U7F8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015958001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7F8"/>
    <dbReference type="STRING" id="49390.A0A068U7F8"/>
    <dbReference type="Gramene" id="CDP03553">
        <property type="protein sequence ID" value="CDP03553"/>
        <property type="gene ID" value="GSCOC_T00015958001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7F8"/>
    <dbReference type="OMA" id="ATCWFTA"/>
    <dbReference type="OrthoDB" id="1319532at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7F8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980:SF6">
        <property type="entry name" value="PROTEASE DO-LIKE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="23539" checksum="2198C886733BB1E4" modified="2014-10-01" version="1">MATAAATCWFTALTSATGPSRYSLTSQRFFATTLRRHSHLIAPNSETNQNAETHAAVNPNRKSRTSKKPLPSSPRKSSAQKEAVGQRFPGTSKDEVHFSRADARGSKTGRSQRNQPVAFKSFGLQKKGNKGGNNVFDIKEQQAETGNFQDAAFLNAVVKVYCTHTAPDYSLPWQKQRQYTSTGRQVYCLHHPLIFLVVDVKESSVFISLSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8B5</accession>
    <name>A0A068U8B5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SULFUR DEFICIENCY-INDUCED 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00016350001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MS5 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8B5"/>
    <dbReference type="FunCoup" id="A0A068U8B5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8B5"/>
    <dbReference type="Gramene" id="CDP03853">
        <property type="protein sequence ID" value="CDP03853"/>
        <property type="gene ID" value="GSCOC_T00016350001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8B5"/>
    <dbReference type="OMA" id="IMGKLDL"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8B5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044961">
        <property type="entry name" value="MS5/SDI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36326">
        <property type="entry name" value="PROTEIN POLLENLESS 3-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36326:SF14">
        <property type="entry name" value="PROTEIN SULFUR DEFICIENCY-INDUCED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP03853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33327" checksum="802E2C3D2431E1B9" modified="2014-10-01" version="1">MSSPTKEMNNGDKDSLFHVIHKVPFGDGPYVRAKHAQLVQKDPESAIVLFWKAINAGDRVDSALKDMAVVMKQLDRTEEAIEAIKSLRGLCSKQAQGSLDNVLIDLYKKCGRVDEQISVLKQKLRMIYLGQAFNGKPTKTARSHGKKFQVSVKQETSRILGNLAWAYMQKSNYISAEVVYRKAQMIEPDANKACNLCHCLIQQARYDEARLILDDVLQGKLAGSHDPRTGARAQELFLELQTRQPPPQFPGLDSEDDRDFVDELERLLDVWAPPRSRRLPIFEEITPFRDQMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8Q2</accession>
    <name>A0A068U8Q2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00016507001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8Q2"/>
    <dbReference type="FunCoup" id="A0A068U8Q2">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8Q2"/>
    <dbReference type="Gramene" id="CDP03988">
        <property type="protein sequence ID" value="CDP03988"/>
        <property type="gene ID" value="GSCOC_T00016507001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8Q2"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="449109at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8Q2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Hemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047048">
        <property type="entry name" value="TlyA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00478">
        <property type="entry name" value="tly"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319">
        <property type="entry name" value="BACTERIAL HEMOLYSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="BACTERIAL HEMOLYSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="4">
        <location>
            <begin position="79"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="319" mass="35449" checksum="3C7E2EE0009B0DED" modified="2014-10-01" version="1">MAHNILKLPFTQKKFLKLPISLNSGSLISLRSRSLFFSSKQLCPLPHFSVKWSNAHMHCRVRGFAAVKSGKIQPQKKKKRLDEICLERFQQYSRTFIQSWILQGKVFVDGKVVYKAGTPIPDKAVVLIKAEIPKYVCRAGHKLEAAIEQLGVDVSGKVALDSGLSTGGFTDCLLQYGASYVYGVDVGYGQVAEKIRQDERVSVIERTNLRYLSELPQKVDLVTLDLSFISILLVMPAVVNVMKEEATLVTLIKPQFEARRSQVGSGGIVRDPAVHQEVLDKIIKGVEDYGFSCKGWIESPLKGAEGNVEFLACFCRTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U906</accession>
    <name>A0A068U906_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00018716001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U906"/>
    <dbReference type="STRING" id="49390.A0A068U906"/>
    <dbReference type="Gramene" id="CDP04669">
        <property type="protein sequence ID" value="CDP04669"/>
        <property type="gene ID" value="GSCOC_T00018716001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U906"/>
    <dbReference type="OMA" id="ANDIREW"/>
    <dbReference type="PhylomeDB" id="A0A068U906"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF187">
        <property type="entry name" value="AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="4">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="491" mass="56101" checksum="1AFD2598CAE365BB" modified="2014-10-01" version="1">MLKTVLNVFLGIVANLGIEWMRSHSGLDAKMKTLERRIRVLTKKARDIHMTIRHEQDLHSGYKRKREVGDWLKNVKRKKMKYQGLKRDYQRRPFPSRISLARYVDAMIQEASDLLQQGSFCGGYVVAVHEESKPLVTEELIGQSVQQNLTDTRALLMDDKVSCIGIYGMPGVGKTAVASHIHNELLKEDKFLKHVYWFSDANSEVSKLQDDLATVLHLDLPNMDAGDDRRAAKLASALERKNKFVIILDGLLTPIDVGTIGIPLGKEGRKLIVVSRSLDVCHRTGCQKEIKVQPLSADEGRMLFMEKLRSRDQELPPDVQEISRSISEKYGGLPLGIIAKARSMIGANDIREWRDALAEMEERPDDAVFEVMKSSFYGLRNERWKTSFLHCSILLKDETVPRDEVVRGLISEGFLDRRCREAKLDQGHTILKALEKACLLDRVVNDGVDCLKMHPLMRDMATEIMKSDPTYMVKHHHYFPAFFFCRTRNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U961</accession>
    <name>A0A068U961_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00020034001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U961"/>
    <dbReference type="FunCoup" id="A0A068U961">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U961"/>
    <dbReference type="Gramene" id="CDP05100">
        <property type="protein sequence ID" value="CDP05100"/>
        <property type="gene ID" value="GSCOC_T00020034001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U961"/>
    <dbReference type="OMA" id="MSIFDQP"/>
    <dbReference type="OrthoDB" id="777519at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U961"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF202">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="390" mass="43079" checksum="3DE130C52A8AAC46" modified="2014-10-01" version="1">MVVRGFLCPVKYTEHRSLTKKLALKPKKSSERSSIVPRTVRISVTDPDATDSSSDEDELFGRLRVKRYISEIKIETAAVCQQNSNNVISASSNALAPRHHPKKKTAEALQAKQRPMKAKEPPVPAAGGAVRKFRGVRQRPWGKWAAEIRDPSTRARLWLGTFDTAEEAAMVYDNAAIKLRGPDALTNFVTPPAKEKPQVNVASTSCYESGEESHNLSSPTSVLRFRSSQSSEEAEPECRSEGVEGPVPADCTDEQTVQEETDGEPWQEPVPEVAEECQGETRDMIPDYSNEYMPMDVPFLDNFFNFQSPEQITFDDTVPPSFSNDTFDLGLDVSFDDDLLPGFLDDTAAAGAGFGELNDSFQDFGSVELNVDDYFQDMNDFASADALLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U979</accession>
    <name>A0A068U979_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clp ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00019980001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U979"/>
    <dbReference type="FunCoup" id="A0A068U979">
        <property type="interactions" value="2766"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U979"/>
    <dbReference type="Gramene" id="CDP05061">
        <property type="protein sequence ID" value="CDP05061"/>
        <property type="gene ID" value="GSCOC_T00019980001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U979"/>
    <dbReference type="OMA" id="EDCWINN"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U979"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF6">
        <property type="entry name" value="CLP PROTEASE REGULATORY SUBUNIT CLPX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="320" mass="34745" checksum="F80EF6F44DF6AD79" modified="2014-10-01" version="1">MQLLQAGYVGEDVESILYKLLTVADYNVAAAQQGIVYIDEVDKITKKAESLNISRDVSGEGVQQALLKMLEGTIVNVPEKGARKHPRGDNIQIDTKDILFICGGAFVDLDKTISERRQDSSIGFGAPVRANMRTGGVTTAAVTSSLLETVESSDLIAYGLIPEFVGRFPILVSLSALTENQLVQVLTEPRNALGKQYKKMFQMNGVKLHFTEVALRLIARKAITKNTGARGLRSLLESILMDSMYEIPDVRTGNEIIDAVVVNGESVGHEGRGSGAKILYGKGALDRYISQLKFKDRETTAEGSDGEPEVEQELPSIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA61</accession>
    <name>A0A068UA61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00020003001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA61"/>
    <dbReference type="STRING" id="49390.A0A068UA61"/>
    <dbReference type="Gramene" id="CDP05079">
        <property type="protein sequence ID" value="CDP05079"/>
        <property type="gene ID" value="GSCOC_T00020003001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA61"/>
    <dbReference type="OMA" id="MITWVGF"/>
    <dbReference type="OrthoDB" id="544400at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654708" description="non-specific serine/threonine protein kinase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="346"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP05079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="612" mass="67904" checksum="E248CD046B350FC1" modified="2014-10-01" version="1">MSKLQILCISFLLLFCCLIIKAQSTSNKNSDHGCVPSSCGNIKNIAYPFRLKGDPKNCGDLDFELDCQNNRTILTLNSKKFHVQAITYDKFTIRAVDPGVDNNDSCSFPTYASIRYDDLPTLVYNKFFDYNIPVAYINCLKPVNASRYLDNTACRSGSAAAGSSSSAFSNSSRVHSYIAVGEDFKVSDLEESCGVEMFTSVSSRGPMKDITTSLASVHELLAYGFELSWFRVLCQECEATHGSCSLQDNTVTCRHYCPEDVPLSQLGFRCQFEFWGGIIALISAIALGGLVGLRFLCGITCLIALVVYKWRRRHLSADETIEEFLQSQTGLAPIKYSYSEIKKMTENFREKLGEGACGSVYKGKLRSGPFVAVKIIENSITSELEYVSEVATIGRIHHVNVVQLIGFCTEGSKRALIYDFMPNGSLDKYIFPRGQSVSLSCEKMFEIALGVARGIDYLHRGSARGTMGYIAPELFYKNIGGVSYKADVYSFGMLLMEMASRRENRNPGAEHVSQIYFPSWAYDHLHAGKDIDMGCATAEERKLVKKMILVALWCIQMKPADRPPMNKLVEMLEGDANLVHMPPKPFLAPREMAEEYGTNTSGGSSSLVLSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAN6</accession>
    <name>A0A068UAN6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00020679001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAN6"/>
    <dbReference type="FunCoup" id="A0A068UAN6">
        <property type="interactions" value="3120"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAN6"/>
    <dbReference type="Gramene" id="CDP05561">
        <property type="protein sequence ID" value="CDP05561"/>
        <property type="gene ID" value="GSCOC_T00020679001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAN6"/>
    <dbReference type="OMA" id="DCQALHT"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="527" mass="58791" checksum="82674A55F8DB7110" modified="2014-10-01" version="1">MGMSSASIAGDTLKLCVFDLRRGQTEGQELDKILFFYPADLAFSTQLSVIGLSEGLITFTRIFSPEAACEVIEAEMHSHVFYEAEPDIWMVMVVEKSKELEAIWRMDALRAVLKEVHSLFVMFHGSIRALLDKEPAGGLIRTHLYYFIMDYLSAFEKRSPFDCCCWDFLAVKKLQLPNFRESLTERGTVQMLTVGREAALEVQSLVKALESSAGSMQCHSLIMYQDLLVSSTLSPDDTVNLFTYAVLRLSPRALSSGVSSWSYLRKGNIAPGVSSGPMLSNSGSALDHSNVSSETSHVGNRQYNALRPLKHDKWSRGKDGFLVADVWGAEVDSSACSSPTIWLHQTTERMYLCAYQYRSLTLIFLIPVTSIVSEEQGISLMKQQIIENASLKIIKVEEKLSRGWGGENAYHVSGYRYLLVDGNRCISRATPPGKVTTLAKESLVALSKVREEVDLEKSRLKCDGAGREKDMEVCIRAKNNAWVIAKLTRGKELYMVLEKVSETILCATDAVEKFSDSRYCNGVFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAW7</accession>
    <name>A0A068UAW7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00020469001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Potassium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAW7"/>
    <dbReference type="STRING" id="49390.A0A068UAW7"/>
    <dbReference type="Gramene" id="CDP05427">
        <property type="protein sequence ID" value="CDP05427"/>
        <property type="gene ID" value="GSCOC_T00020469001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAW7"/>
    <dbReference type="OMA" id="MLLLWKW"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF13">
        <property type="entry name" value="POTASSIUM TRANSPORTER 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="70"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="558"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU321113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP05427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="752" mass="83849" checksum="2A3A3E4C28D2375B" modified="2014-10-01" version="1">MDRHVRPYDSAVTQSDDVVVTVIDHRNNNNDEVGAVSSRSSRFHDLNRLIQSPPTLDNKVTGKWQNLLLAYKTLGVVFGGLVTSPLYVYPSMQLKSPTEENYLGIFSIIFWTLSLIGVVKYASIAVRADDQGEGGTFALYSLLCRNINISILSSKHSRTNSSTAEKPSKLGKFFEASLVARRVLLFIAILGMCMLIGDGVLTPAISVLSAMDGIKAPFPSFSKTWVEVLSAVVLIVLFLLQKYGTSRVSFLFSPIMGAWTLTTPLVGIYSIIKHYPSIYKAISPHYIFSFFWRNGKEGWLLLSGTILCITGSEAMFADLGHFNKSSIQIAFLFTIYPSLVLTYAGQTAYLIRNPYDHQDGFYKFIPSPVYWPMFVIATLAAIVASQSLISATFSIIKQSVALDYFPRVKIVHTSTRQEGEVYSPEVNYILMVICVAVILIFGDGQDIGNAFGVVVTMVMLITTIMLTLVMIIIWRTPPVLVALYFVIFFVMEGVYVSSVFTKIPEGGWIPFAISVVLAFIMFGWFYGRQRKIEYELTHKIDVDSLKALLSDPGIQRVPGLCFFYTKIQDGLTPVLGHYMKNMKSLHNVTVFTTLRYLLVPKVPAHERIIVNKLGLKGVYGCVIQYGYADSLSLEGDDFVLQVTNSLQNHVRDSSDCAQSTTSLDEEIDDIKEAKLAGVVHVRGKTRFHISKSCSWFDRTMLAFYEVLHSNCRSSLPAMGIPLPRCIEVGMHYEVYKITVGSHADGPVHLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB48</accession>
    <name>A0A068UB48_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00021041001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB48"/>
    <dbReference type="FunCoup" id="A0A068UB48">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB48"/>
    <dbReference type="Gramene" id="CDP05765">
        <property type="protein sequence ID" value="CDP05765"/>
        <property type="gene ID" value="GSCOC_T00021041001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB48"/>
    <dbReference type="OMA" id="AWAESHE"/>
    <dbReference type="OrthoDB" id="5103at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB48"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052864">
        <property type="entry name" value="Chloroplast_FAD_CarF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48140">
        <property type="entry name" value="FATTY ACID DESATURASE 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48140:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="8">
        <location>
            <begin position="184"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP05765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="41547" checksum="D8820CBD9B3A4225" modified="2014-10-01" version="1">MTTNAWAESHEPLNSLLLYLFSWYYILRLSGAKWFLLMFAEVATMSAFPHLRSLHHVNQCHYLSPPSHIYRSITTTTTKSRRRHPEPLVVDLPWVLNTSTPATTTIPLDDPSLQSTDPPPVLKRSTPVATTSMLNDPSLKSKWSHRAWVASGGTTVLVSLAKSVTGAVDSGTWLQPILAGVVGYVLADLGSGVYHWGIDNYGDENTPVFGSQIEAFQGHHNWPWIITRRQFANNLHALARAVSFTVLPMDLIFNDPVLHGFVSVCSGCIMFSQQFHAWAHTTKSKLHPLVVALQDAGVLVSRSMHGAHHRPPYDSNYCIVSGVWNELLDTYKVFEALEMILFFKLGVKPRSWSEPSSNWTEETDTSSLIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBG8</accession>
    <name>A0A068UBG8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00020648001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBG8"/>
    <dbReference type="STRING" id="49390.A0A068UBG8"/>
    <dbReference type="Gramene" id="CDP05539">
        <property type="protein sequence ID" value="CDP05539"/>
        <property type="gene ID" value="GSCOC_T00020648001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBG8"/>
    <dbReference type="OMA" id="CSISANR"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBG8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000020">
        <property type="entry name" value="Beta-glucosidase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF175">
        <property type="entry name" value="BETA-GLUCOSIDASE 18-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654656" description="Beta-glucosidase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP05539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61221" checksum="A7AB8448E14F9E15" modified="2014-10-01" version="1">MKVTTMLSSSSFLLLILLISANPYARALQGGNGIEEELEDVKRSDFPTGFLFGVATSSYQIEGAILEDGKSLSNWDVFVHKNGNVNNGDTGDIATDHYHRYLEDIETIHSLGVDAYRFSISWSRILPNGKLGGVNAAGIMFYNSIIDNLLLRGIQPFVTIHHWDIPQVLSDEYGGWLNPLIQDDFVHFAETCFKNFGDRVRYWVTINEPNIAADFAYERGKHPPGHCSPPFGNCSAGNSDTEPLIAMHNMLLAHAKASKLYREQFQASKILRGVIGIVVHAIMYEPFTDDEHDKEAVKRALANNVAWAFDPLVFGDYPPEMRRYHGNELPKFTPEERLLIRDSIDFLGLNHYATLYAKDCIRSSCVSSNSACAPGGDRAIRGFVCTTAERGGVLIGEPTGLPTFSVVPRGMEEIVDYVKNRYHNKPMLITENGYSTPPQQEQVDDFQLDVKRIAFHKAYLAFLARAMRNGADVRGYFVWTLMDDFEWSLGYDVKFGLYSVDRATLNRTPRSSAKWYRNFLGNISSSSMKPRTAVAFWSKVGRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBI0</accession>
    <name>A0A068UBI0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021118001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBI0"/>
    <dbReference type="FunCoup" id="A0A068UBI0">
        <property type="interactions" value="1490"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBI0"/>
    <dbReference type="Gramene" id="CDP05826">
        <property type="protein sequence ID" value="CDP05826"/>
        <property type="gene ID" value="GSCOC_T00021118001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBI0"/>
    <dbReference type="OMA" id="HAFQAFE"/>
    <dbReference type="OrthoDB" id="659599at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33625">
        <property type="entry name" value="OS08G0179900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33625:SF4">
        <property type="entry name" value="OS08G0179900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="326" mass="34222" checksum="29E8EBACA8A88ED6" modified="2014-10-01" version="1">MGGGGAMRAAAKVAGFGVLNGGLRGIVPDHPASTAMRKVLRPVTGLASPSAPENVKEAAVAIDVSPVQKPCWEFDDWELAGGEEDLFGGSGVSTPRLVFGGAPSIAEAKEATYELKEALEKVYLSAPSTPKTGLSGLSRSEVPETKACVTSETILAPAPKHAIQAFTFLNESPAVQSVVASIASDPNVWNAVLLNPTLQDYIQSQKMGAPSSTTDQYEKGSTADSDIPSPRSPRSVSSDRAESEYGESNSTGRFMELWQELKLTVVDMMNSLSDYFQALFGGYSNNKGAADTNGNVFSGFVDKALGPSLMGLAVMVIVVVVLKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBR0</accession>
    <name>A0A068UBR0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AtTam37 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021253001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBR0"/>
    <dbReference type="STRING" id="49390.A0A068UBR0"/>
    <dbReference type="Gramene" id="CDP05931">
        <property type="protein sequence ID" value="CDP05931"/>
        <property type="gene ID" value="GSCOC_T00021253001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBR0"/>
    <dbReference type="OrthoDB" id="1686323at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBR0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056892">
        <property type="entry name" value="Zf-AtTam37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36404">
        <property type="entry name" value="EMBRYO DEFECTIVE 2737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36404:SF1">
        <property type="entry name" value="EMBRYO DEFECTIVE 2737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25112">
        <property type="entry name" value="zf-AtTam37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AtTam37 zinc finger" evidence="1">
        <location>
            <begin position="90"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="237" mass="26380" checksum="1E89BFF0D7D82CF7" modified="2014-10-01" version="1">MSRGINPLLKSLQQKADLQYKLFTRRYGQQIIDILDFPVKLVLSPFTLAYDIAGSAPRGFGIPEFISKLSYSAIFVVATVGTYDIAMELGKKVLCQRNCWTCNGWNALQCTMCKGSGKVQYQVRSYTLKSGEKATAESIANAIAENRAELTHLPSTMDLHVPLPTKDCPNCDGSGVMKCPECKNKLQIRISADDIMEPPWKAYNIMRKMNYPYEASAMPSAFLNNKSVAFHSFCCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDA4</accession>
    <name>A0A068UDA4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023436001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDA4"/>
    <dbReference type="STRING" id="49390.A0A068UDA4"/>
    <dbReference type="Gramene" id="CDP06545">
        <property type="protein sequence ID" value="CDP06545"/>
        <property type="gene ID" value="GSCOC_T00023436001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDA4"/>
    <dbReference type="OMA" id="KFCRRFW"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDA4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06472">
        <property type="entry name" value="ACD_ScHsp26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000009">
        <property type="entry name" value="17.6 kDa class I heat shock protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="134" mass="15123" checksum="46A81EE855B25F3C" modified="2014-10-01" version="1">MALIPKLFGDMLAPSGLSDETKGIVNARVDWKETPEAHVFKVDLPGLKKEEVKVEVEDGRVLAISGERAAEKEDKNDKWHRVERSRGRFTRKFLLPENAKVEEVKANMEYGVLTVTIPKQEVKKPEVRAIEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEJ0</accession>
    <name>A0A068UEJ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor AS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00023518001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEJ0"/>
    <dbReference type="STRING" id="49390.A0A068UEJ0"/>
    <dbReference type="Gramene" id="CDP06609">
        <property type="protein sequence ID" value="CDP06609"/>
        <property type="gene ID" value="GSCOC_T00023518001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEJ0"/>
    <dbReference type="OMA" id="HKKETAW"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEJ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052844">
        <property type="entry name" value="Leaf_Dev_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47214">
        <property type="entry name" value="PROTEIN ROUGH SHEATH 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47214:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR AS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23328" checksum="DE1A7A625EAC506D" modified="2014-10-01" version="1">MATSSGQFVCTDPLAPSPPILLPPWLSNSTSGVPVRPSSPSVTLSLSPSVVPPPGAAWLQPDRDSKNPVSNSLPCLGMVPPPPSREKAAVVSELLECCKELEEMQRAWAVHKKEAAWRLRRVELQAESEKACKRREKMEAIEAKVKALKEEQKATLDRIEAEYREQLGGLRRDAEAKEQKLAEQWSAKHSRLTMFLEQMGCQSKFVEPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFN9</accession>
    <name>A0A068UFN9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024491001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of either four A chains (GAPDH 2) or two A and two B chains (GAPDH 1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFN9"/>
    <dbReference type="FunCoup" id="A0A068UFN9">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFN9"/>
    <dbReference type="Gramene" id="CDP07271">
        <property type="protein sequence ID" value="CDP07271"/>
        <property type="gene ID" value="GSCOC_T00024491001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFN9"/>
    <dbReference type="OMA" id="QVKLYVW"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="10">
        <location>
            <begin position="92"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="458" mass="49142" checksum="AEE44A169A964937" modified="2014-10-01" version="1">MASTHAALASSRIPANTRLVSKTSHYNSFPTQYSFSKRLEVDEYSGLRSSGCVTFATNSRETSFFDAAAVQLTPKRQNAGSTPVKGETVAKLKVAINGFGRIGRNFLRCWHGRKNSPLDVIVVNDSAGVKNASHLLKYDSMLGTFKADVKVVDTETISVDGKPIQVVSSRDPLKLPWADLGIDIVIEGTGVFVDGPGAGKHIQAGAKKVIITAPAKGADIPTYVVGVNEQDYYHEVSNIVSNASCTTNCLAPFVKVLDEEFGIVKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVSLVLPQLKGKLNGIALRVPTPNVSVVDLVVNVEKRGLTAEDVNAAFRKAADGPLKGILDVCDAPLVSVDFKCTDVSSTIDSSLTMVMGDDMVKVVAWYDNEWGYSQRVVDLAHLVASKWPGLFIDGSGDPLEDYCKTNAADEECKVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG65</accession>
    <name>A0A068UG65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Splicing factor U2af small subunit B-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00024455001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Probably active at the 3' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG65"/>
    <dbReference type="FunCoup" id="A0A068UG65">
        <property type="interactions" value="2897"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG65"/>
    <dbReference type="Gramene" id="CDP07247">
        <property type="protein sequence ID" value="CDP07247"/>
        <property type="gene ID" value="GSCOC_T00024455001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG65"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG65"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12539">
        <property type="entry name" value="RRM_U2AF35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="191"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP07247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33775" checksum="A7EC3367AB354292" modified="2014-10-01" version="1">MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHNRPTISPTLLLSNMYQRPDMITPGVDPQGQPIDPRKIQEHFEDFYEDIFEELGKFGEIESLNVCDNLADHMIGNVYVQFKEEDHAAAALQALQGRFYSGRPIIADFSPVTDFREATCRQFEENSCNRGGYCNFMHVKMIGRDLRRKLFGRYRRYRRSRSRSRSASPHPHHHHRRERERERDYDRSRGGERDFRASGRRSGGDRHARHETDSSGGRRRHPTSPRRSKSPVREGSEERRARIEQWNREREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGA7</accession>
    <name>A0A068UGA7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024912001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGA7"/>
    <dbReference type="STRING" id="49390.A0A068UGA7"/>
    <dbReference type="Gramene" id="CDP07605">
        <property type="protein sequence ID" value="CDP07605"/>
        <property type="gene ID" value="GSCOC_T00024912001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGA7"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGA7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053283">
        <property type="entry name" value="TUNICAMYCIN_INDUCED_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34454:SF3">
        <property type="entry name" value="PEPTIDASE I, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34454">
        <property type="entry name" value="TUNICAMYCIN INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654863" evidence="1">
        <location>
            <begin position="41"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="252" mass="28536" checksum="65FB0A0763EBAAA0" modified="2014-10-01" version="1">MSINSQSQSQSHPPLFSNLHFMTVVLVLLLLLTSLTPSAGSPSIPPSFNLSHYFLFPTSNDVVNNRQHHHRSHSQPNSSPFLKDVLTEIGAREKWDLQEFSVSKLDVKKAKLGDLQRYEFRVRFGKSEFVFKLLDQVSRWKRFEQLENELGFEDLVSKITSKAAVLGTLKIQGPFHLRLAGDHHLKLFLPLKNSFSGLKDILVGEGITVEITGAEEVSLFHPTSASSSLGRTDYRYFWPSLCMAWPPIRVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI95</accession>
    <name>A0A068UI95_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00026678001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI95"/>
    <dbReference type="Gramene" id="CDP08017">
        <property type="protein sequence ID" value="CDP08017"/>
        <property type="gene ID" value="GSCOC_T00026678001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI95"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="55" mass="6347" checksum="13C353B1376FF967" modified="2014-10-01" version="1">MEMEESSASAPNSNQLQEKQPVQEIPTINFIPDEVLEDILTRLPVKSVLRFRFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI99</accession>
    <name>A0A068UI99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027014001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI99"/>
    <dbReference type="Gramene" id="CDP08245">
        <property type="protein sequence ID" value="CDP08245"/>
        <property type="gene ID" value="GSCOC_T00027014001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI99"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26123" checksum="F0EE24B601B1FA84" modified="2014-10-01" version="1">MHSYKVPQICVAIFSIYIVIVGCGFCLNVKSNILGFPAGLCPIVGVGGHISGGGYGSPLQRYCLMVDNVLDAQIIDVNSQVLDRKEMGEDLFGAIRDGGSASFGVVFAYRIRLVRVPEIHTVFNVQKTKAENATDVLYKWQNVADKIDNDLFIRVLVQPNTGKVKNANRLISSNILGFPAGLCPIVGVGGHISGGGYGSLLQRYCLMVDNVLDAQIIDVNSQVLDRKEMGEDLFGAIRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ79</accession>
    <name>A0A068UJ79_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027475001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ79"/>
    <dbReference type="FunCoup" id="A0A068UJ79">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJ79"/>
    <dbReference type="Gramene" id="CDP08531">
        <property type="protein sequence ID" value="CDP08531"/>
        <property type="gene ID" value="GSCOC_T00027475001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ79"/>
    <dbReference type="OMA" id="FLSMKIY"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ79"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044795">
        <property type="entry name" value="THA8L-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46870:SF1">
        <property type="entry name" value="OS03G0297700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46870">
        <property type="entry name" value="PROTEIN THYLAKOID ASSEMBLY 8-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29348" checksum="A63D5D869322856B" modified="2014-10-01" version="1">MWRQGLRRVSSNLITPLHHPNSSFRQIFSHQALGSPSSTSGSSSPSLSIWRRKKEIGKEGLMVAKELKRLQTNPIRLERFMKSHVSRLLKSDLIAVLAEFQRQDLVFLSIKLYEVVRKEIWYRPDMFFYRDMLMMLARNKRVDEARSVWDDLKREGVLFDQHTFGDLIRAFLDSGLPKEAMDIYEEMRLSPDPLLSLPYRVILKGLLPYPELREKIKDDFLELFPNMIVYDPPEDLFDDQQWEKDDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ88</accession>
    <name>A0A068UJ88_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00027044001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ88"/>
    <dbReference type="FunCoup" id="A0A068UJ88">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJ88"/>
    <dbReference type="Gramene" id="CDP08269">
        <property type="protein sequence ID" value="CDP08269"/>
        <property type="gene ID" value="GSCOC_T00027044001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ88"/>
    <dbReference type="OMA" id="YGTAGMK"/>
    <dbReference type="OrthoDB" id="494308at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ88"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd05255">
        <property type="entry name" value="SQD1_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="94"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="484" mass="53620" checksum="D9F3AD76E195637A" modified="2014-10-01" version="1">MAHLLSTSCSLNIPPSCKKPKCLLVNQCSSSGFPASFSLPTSTSRSKMLILHGKGPKRSSTIYAKAVSLSQESKAQPGSSFPQETGEAGSPKKVMVIGGDGYCGWATALHLSNRNYEVAIVDNLVRRLFDHQLGLDSLTPISSIHNRIRCWKSLTGKDIQLHIGDICDFEFLAETFKSFEPDAVVHFGEQRSAPYSMIDRSRAVFTQQNNVIGTLNVLFAIKEYRDECHLVKLGTMGEYGTPNIDIEEGYITITHNGRTDTLPYPKQASSFYHLSKVHDSHNIAFTCKAWGIRATDLNQGVVYGLRTDETAMHDELCNRFDYDGVFGTALNRFCVQAAVGHPLTVYGKGGQTRGYLDIRDTVQCVELAIANPAQRGEFRVFNQFTEQFSVNELAALVTKAGEKLGIEVKTVSVPNPRVEAEEHYYNAKHTKLIELGLKPHLLSDALLDSLLNFAIKYKDRVDPKQIMPSVSWRKIGVKPKTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK97</accession>
    <name>A0A068UK97_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00027725001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK97"/>
    <dbReference type="FunCoup" id="A0A068UK97">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UK97"/>
    <dbReference type="Gramene" id="CDP08677">
        <property type="protein sequence ID" value="CDP08677"/>
        <property type="gene ID" value="GSCOC_T00027725001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK97"/>
    <dbReference type="OMA" id="SHTTMCF"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UK97"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000033">
        <property type="entry name" value="O-acyltransferase (WSD1-like) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF74">
        <property type="entry name" value="O-ACYLTRANSFERASE WSD1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="16">
        <location>
            <begin position="57"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="17">
        <location>
            <begin position="354"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="505" mass="56889" checksum="DFC4F38C6AE5570D" modified="2014-10-01" version="1">MDSPTGIRWRRLGGLKPIKTKRKSKEVEADTNKNMVEEEEPLSPSARLFHEPNFNVHVTTILGIKTPLSPQVIKEKLMHSLVKHPRFSSLQVVDEKAGEMKWVRTKVDIDQHVVVPDLDRNMGSPDKFVEDYVYNLSKSSLDKSKPLWDLHVLNVKTSDAQGVAVVRIHHSLGDGTSLMSLLLACTRQVADPDKLPTIPGQNKKTTNSFSGLSKPKFWKYYLIAVWLFIQLIWNTIRDIVIFGATALFLKDTKTPIKAPPCSELNPRRVVYRIVSLDDMKVTINDVALGITQAGLSRYLNRRYAEGKKDEGETQKRNNLPKNIRLRSTILINLRPSAGIQVLADMMEKDAEAKWGNWIGFVLLPYKIALRDDPLDYVREAKATIDRKKNSLEAVYTFSIADLVLKFFGVKASSDLSHRIITQTTMCISNIVGPQEEIGFYGHPIAYLASGSYGQPHALMINFQSYVNKMTMVLSVDESVIPDPHQLLDDLQLSLQLIKDAVLASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULE8</accession>
    <name>A0A068ULE8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00028692001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May donate electrons to ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULE8"/>
    <dbReference type="FunCoup" id="A0A068ULE8">
        <property type="interactions" value="2873"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULE8"/>
    <dbReference type="Gramene" id="CDP09360">
        <property type="protein sequence ID" value="CDP09360"/>
        <property type="gene ID" value="GSCOC_T00028692001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULE8"/>
    <dbReference type="OMA" id="QFFRAPY"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULE8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP09360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="26253" checksum="D152150D3D18F71D" modified="2014-10-01" version="1">MASILARKSLAGFRARQLAAAGQAWQDLSRFALVNGSRTFATKHSFSTDKDDEEREKLAKEISKDWNSVFERSINTLFLTEMVRGLSLTLKYFFEKKVTINYPFEKGPLSPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEEREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFATETHEELLYDKEKLLENGDRWETEIAENLRSESLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULP5</accession>
    <name>A0A068ULP5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00028368001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULP5"/>
    <dbReference type="STRING" id="49390.A0A068ULP5"/>
    <dbReference type="Gramene" id="CDP09154">
        <property type="protein sequence ID" value="CDP09154"/>
        <property type="gene ID" value="GSCOC_T00028368001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULP5"/>
    <dbReference type="OMA" id="PTIVECR"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULP5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF319">
        <property type="entry name" value="LACCASE-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0052">Apoplast</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658073" description="laccase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP09154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="371" mass="41486" checksum="A5C16F9431CDCA30" modified="2014-10-01" version="1">MATWFQVVVLIACLLPSLVECRVREYKFNVVMANATRLCSTKPIVTVNGQFPGPTIYAREDDTVLIKVVNHVKYNLSIHWHGVRQLRTGWADGPAYITQCPIQPGQTYVYNFTITGQRGTLWWHAHILWLRATLHGALVILPKPGVPYPFPSPHEETIVILGHIKSIEFLTCMQFQFVQIPSLRLTIVHAFMRHNYSFWFRLPVDPGKKYMLRIINAALNDELFFKIAGHNLTIVEVDAAYVKPFTTDTILIAPGQTTNAIVSTDQESGKYLMAASPFMDAPIAVDNLTATATLRYSGTVSSIATTLTSLPSKNATPVATKFMDSLRSLNSQEYPAQVPLDIDHSLLFTISIGINPCATLEYSLMIFQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMX7</accession>
    <name>A0A068UMX7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028132001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMX7"/>
    <dbReference type="FunCoup" id="A0A068UMX7">
        <property type="interactions" value="3120"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMX7"/>
    <dbReference type="Gramene" id="CDP08978">
        <property type="protein sequence ID" value="CDP08978"/>
        <property type="gene ID" value="GSCOC_T00028132001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMX7"/>
    <dbReference type="OMA" id="WFFHKEL"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMX7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000004">
        <property type="entry name" value="probable NOT transcription complex subunit VIP2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="531"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="663" mass="70654" checksum="A66524E4527E7BBF" modified="2014-10-01" version="1">MSGLLNSSLNGSASNIPDSSGRSFTTSFSAQSGAASPVFHHTGGIQGLHNMHGSFNVPNIPGTLGSRNTTMSNVPSSGVQQSAGNLSSGRFTSNNIPVALSQISHGSSHGHSGMTNRGGMSVIGSPGYSSSTNGVGGSIPGILPTSAAIGNRNAVPGLGVSPLLGNAGPRITSSVGNVVGGGNIGRSMSSGGGLSMPGLASRLNLTANSGSGNLNVQGPNRLMSGVLQQASPQVISMLGNSYPSAGGPLSQNHVQAVNNLNSMGMLNDVNSNDGSPFDINDFPQLSSRPSSAGGPQGQLGSLRKQGLSPIVQQNQEFSIQNEDFPALPGFKGGNADYGMDLQQKEQVHDNAVSLMQPQQFSMGRSAGFNLGAAYSSHRPQQQQHTPSVSSSGVSFSNLNNQDLLHLHGSDMFPSSHPNYHQQTSGHPGIGLRPLNSQNTVSGIGSYDQLIQQYQQHQNQSQFRLQQLSSVSQPYRDQGLKSMQASPTAPDPFGLLGLLSVIRMSDPDLTSLALGIDLTTLGLNLNSTENLHKTFGSPWSDEPAKGDPEFTVPQCYYAKQPPPLTQAYFAKFQLDTLFYTFYSMPKDEAQLYAANELHNRGWFFHKELRLWFTRAPNVEPLVKTNSYERGSYISFDPNTWETIRKDNFVLHYEMLEKRPTLPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMY1</accession>
    <name>A0A068UMY1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030377001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMY1"/>
    <dbReference type="FunCoup" id="A0A068UMY1">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMY1"/>
    <dbReference type="Gramene" id="CDP09895">
        <property type="protein sequence ID" value="CDP09895"/>
        <property type="gene ID" value="GSCOC_T00030377001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMY1"/>
    <dbReference type="OMA" id="RICVHEM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000207">
        <property type="entry name" value="Putative cytochrome P450 superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951:SF3">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 706, SUBFAMILY A, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951">
        <property type="entry name" value="OS08G0547900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="377" mass="42953" checksum="4426B45685706CF2" modified="2014-10-01" version="1">MLRKVCVREMLSNATLDSVYDLRRRELRQTIKFLYRQAGKPVNVGEQMFLTVLNVITNMLWGGTVKGDERASLGAEFRQVVNEMTGCLGAMNISDFYPALARYDLQGVQKKTRILAGRFDKIFERMIDQRVNAVGDDGKESKDFLQFLLQLKDEGDAKAPLTMTHVKALLMDMVVGGTDTTSNTVEFALAEMLRKPEILKNVQQELETVVGKDRIVEESDIQKLPYLYAVMKEVLRLHPVLPLLIPHCPSETCIVGGYTVPKGSRVFINVWAVHRDPSIWENPSEFRPERFLDGKWDYSGNDFNYFPFGSGRRICAGTAMAERMFMFSLASLVHSFDWKVPEGEHLNLEEKFGIVLKKRMPLVAIPIPRLSDAFLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNJ8</accession>
    <name>A0A068UNJ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00030561001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP10021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNJ8"/>
    <dbReference type="FunCoup" id="A0A068UNJ8">
        <property type="interactions" value="2046"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNJ8"/>
    <dbReference type="Gramene" id="CDP10021">
        <property type="protein sequence ID" value="CDP10021"/>
        <property type="gene ID" value="GSCOC_T00030561001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNJ8"/>
    <dbReference type="OMA" id="CISNGEA"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNJ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000007">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="10"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP10021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="233" mass="25513" checksum="96CF9E716F35308F" modified="2014-10-01" version="1">MAAESPSAKRWLPLEANPDVMNQFLWGLGVSPEEAECCDVLGLDEELLEMVPKPVLAVLFLYPITPQTEEEKLKKDSLIKDPSAGVYFMKQTVGNACGTIGLLHAVANITSEINLAEGSYLDKFFKTTANMNPEERAVFLENDREMEVAHSVAANGGDTEARDNVDTHFICFTCVNGQLYELDGRRSGPVSHGSSSSSSLLHDAAKVIRKMMEKNPDSLNFNVMAISKSVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPT7</accession>
    <name>A0A068UPT7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00031180001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPT7"/>
    <dbReference type="FunCoup" id="A0A068UPT7">
        <property type="interactions" value="3610"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPT7"/>
    <dbReference type="Gramene" id="CDP10451">
        <property type="protein sequence ID" value="CDP10451"/>
        <property type="gene ID" value="GSCOC_T00031180001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPT7"/>
    <dbReference type="OMA" id="PECSRMY"/>
    <dbReference type="OrthoDB" id="25157at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPT7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="93525" checksum="5583A7175D31A5FD" modified="2014-10-01" version="1">MDSSSSMSSPAIMVGDSNNNVSSNNRDGALSPTAAASLRGSMEDDVALSVAAGLAKEAALLFQAGKFAECVSVLKQLLHKKEDDPKILHNIAIAEYFQDGCSDPKKLLEELNNVKKRSEALAHASEEQQTESVGSTSRLAVGSKGNSNVSNSYSVTSSLPVVYTDEFDTSVTIFNTAVIWFHLHEYAKSYRILDALYQNIEPIDEGTALRICLLLLDVALFSNHASRSADVISYVEKVFCANSMTNQVDNGSSLHQPTMVSKSASFSATIPGASNSDSASSANVLESSLSRTLSEEALEDESLQLLSSLDIGGENLPRPSSLQSSNDVSRTQTDDSISTVDLRLKMHLYKVSFLLLTRNIKAAKREVKMAMNIARGKDYTWALYLKSQLEYARGNHRKACKLLMASSNLTEIGISSMYYNNFGCIFYRLGKYHASSVFFSKALRYRSTLLKEKPVKLATFSQVKSWQMAYNSGLSLLSCGKPIHAAQCFYKAGLTYYNRPLLWLRIAECCLMALEKGLLKSNYSSPSDGSDVKVHVVGKGKWRQLALEDGVSRTGKFDSVGRDDFSFGNGRLPELSMSLARQCLLNALHLLESSDSKYLKSGLLSDSAAEGSESGDSSASKATNYKNLAGGDPKLLNAAVGSGQANTNGEVKEQKGGNGQNTSLLNSVSDYEDICRKENQMIEQALLADMAYVELELENPLKALSTAKSLLKLFECSKIYVFLGHLYAAEALCLLNRPKEAAEHLSVYVTGGSNVQLPYSQDDLEKWSVEKIVDFEEPNGGPSSVNASSSDEFQGFTFLKPEEARGTICANLALLAAELGDPGLVQDVMQATASALNSPHVILATCNRIRFLPGRSTLDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQA8</accession>
    <name>A0A068UQA8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">hAT-like transposase RNase-H fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031486001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQA8"/>
    <dbReference type="STRING" id="49390.A0A068UQA8"/>
    <dbReference type="Gramene" id="CDP10690">
        <property type="protein sequence ID" value="CDP10690"/>
        <property type="gene ID" value="GSCOC_T00031486001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQA8"/>
    <dbReference type="OMA" id="RRYKEYD"/>
    <dbReference type="OrthoDB" id="1301613at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQA8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025525">
        <property type="entry name" value="hAT-like_transposase_RNase-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF52">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN DAYSLEEPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14372">
        <property type="entry name" value="hAT-like_RNase-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="hAT-like transposase RNase-H fold" evidence="1">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="148" mass="17049" checksum="F4AC451164B92828" modified="2014-10-01" version="1">MLLAPSELKEVFSCLDTSDTDYKEAPSLEDWKQVETLCTYLKPLFETANLLTAPTVLTTNTFFHEAWKIQLELGRAVGSEDPFISSLTKSMQEKFDKYWKICCFILAIAVVMDPRFKMKLVEFSFSKIYNEEATTYVKISLPCTFRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQD2</accession>
    <name>A0A068UQD2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030275001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQD2"/>
    <dbReference type="FunCoup" id="A0A068UQD2">
        <property type="interactions" value="2578"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQD2"/>
    <dbReference type="Gramene" id="CDP09808">
        <property type="protein sequence ID" value="CDP09808"/>
        <property type="gene ID" value="GSCOC_T00030275001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQD2"/>
    <dbReference type="OMA" id="YVVMQAA"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQD2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="463" mass="52112" checksum="F5F9942C280D856D" modified="2014-10-01" version="1">MELPEMESMASAIGVSVPVLRFLLCFVATIPVSFLHRFVPGVTGRHLYAAVTGAVLSYLSFGFSSNLHFLVPMLLGYASMVISRKHCGIITFFVAFGYLIGCHVYYMSGDAWKEGGIDATGALMVITLKIISCVINYGDGSLKEENLREAQKKNRLEKLPSFLEYFGYCLCCGSHFAGPVYEMKDYLEWTERKGIWKASEKGSPSPYGATIRAIVQAAICMGLYLYLVPHYPLARFSEPIYQEWGFWKRLSYQYMSGFTARWKYYFIWSISEASMIISGLGFSGWSDSSPPKPKWDRAKNVDILGVEFAKSAVQLPLVWNIQVSTWLRHYVYERLVQDGKKAGFFQLLATQTVSAVWHGLYPGYMIFFVQSALFIAGSRVIYRWQQATSAALFKKILVFLNFAYTLLVLNYSCIGFLVLSLHETLAGYGSVFYVGTILPIALILLGNIIKPAKPARSKARKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR65</accession>
    <name>A0A068UR65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033025001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR65"/>
    <dbReference type="Gramene" id="CDP11040">
        <property type="protein sequence ID" value="CDP11040"/>
        <property type="gene ID" value="GSCOC_T00033025001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR65"/>
    <dbReference type="OMA" id="FLANRNC"/>
    <dbReference type="OrthoDB" id="1304301at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR65"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06222">
        <property type="entry name" value="RNase_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044730">
        <property type="entry name" value="RNase_H-like_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF84">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="356"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="522" mass="58672" checksum="15AC447B8E327953" modified="2014-10-01" version="1">MVHAKLPSQCVARIRRATGFGLKSFPVRYLGCPLFVGRRKCLYFMELVQSVISKVSSWRSKFLSNGGRIVLIKHVLSAIPTHLLAASCPPKGVLALVERAMANFLWGEREGGLRHHWIKWADLCAESSQGGVGVRSLLDVHTAFSFKLWRLLQIREVAEQNLWWEMRAGQCNFWFDNWMGSGPLCQRLQSVSDHLVRDFVLNGRWNQQLLRLWVPDDIVSEIVTKVAPVGSADDRAVWALTESGDFSISSTYELLGSQTPSSFMFERVWHPVIPIKISFFMVRLLRDRLPLASSLGRLQVYGPSKCFCCLASQSETLDHVFADEFIGVGSWSAVLSIFSRWRPRYSHRVVCWEFPVQGAFKLNTDRCSLGNPGVSGGGGVLRDSSGTLLFGFAVPFGELTCLQAEIKALVFGVQQCRLRGFSRIRVEMDSLVLVNLLVRQFRCPWSVRSDLESLRAVQGLEWTVGHCYREMNQVADALAKVGAHAEGVILYTTQSELPRVARGALRLDRSQTPTIRTRAISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URG5</accession>
    <name>A0A068URG5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00033014001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URG5"/>
    <dbReference type="STRING" id="49390.A0A068URG5"/>
    <dbReference type="Gramene" id="CDP11031">
        <property type="protein sequence ID" value="CDP11031"/>
        <property type="gene ID" value="GSCOC_T00033014001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URG5"/>
    <dbReference type="PhylomeDB" id="A0A068URG5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655124" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="42744" checksum="EE45391E4EB10A69" modified="2014-10-01" version="1">MQRTYFLVLGAIALHFVTTSSASISIANNHNNSASDLNALRAFKATIFDRQRIIPTNWSTSSSVCNWIGITCNARHHRVAAIDLSYMGIVGTIPPQLGNLSFLVRLNVMNNSFHEHLPTELSHRLTYINLEGNAFEGEPPSWLGGLTALQYSFRDNGFSEEFSALPKLTVLDIQHNQLVGPLPWDLFNLSSLQIIGFTNNSLWGYLPAHICNYLPQLQALYLSLNNFEGEIPSGIGECSRLQVLSLSSNKFRGHIPKGVWNLTTLTQIHLGGTDLTGKLPTSLCFEKFLLDISNDPFFLHSLFINEMFEILSHRNIDWISKSIVKPLTCYTNGLAGLMSRPGLMTMPNTQFCLISLEFRNTYMLYKYNYAMPLIIFIIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT20</accession>
    <name>A0A068UT20_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00033634001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the auxin efflux carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UT20"/>
    <dbReference type="Gramene" id="CDP11399">
        <property type="protein sequence ID" value="CDP11399"/>
        <property type="gene ID" value="GSCOC_T00033634001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT20"/>
    <dbReference type="OMA" id="NIELAFW"/>
    <dbReference type="OrthoDB" id="2133778at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT20"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014024">
        <property type="entry name" value="Auxin_eff_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00946">
        <property type="entry name" value="2a69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF2">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="362" mass="40212" checksum="B764D58D10696EA7" modified="2014-10-01" version="1">MIGWEDVYKVVTAMTPLCVALALGYASVKWWHMFTPDQFDAINRFNCFFIIPFFNFKFISHINPYELNYPFLGADCIAKCIVLIVLVFWTNCTRKGSCMWSITAFSLCSLNNTLIVGVPLLKAMYGEVGEDLVVQSSVIQSLVWVIFLLFMLEFRREWSKTKSVTNTINGDLQLQAIECGSDLDQNSTPMSMSINKAPSIWSILKIVWLKLAKNPNFYACIAGLIWALLASRWQFKMPEIIEGSILIMSKAGAGVSMFSMGLFMALQERVIACGTPLTLFGMALRFVVSPATMAIGSIVSGLHGNVLRIALIQAALPQSIASFVYAQEYGLHPDILSTAVIFGTIVSLPLLIAYYALLEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTQ4</accession>
    <name>A0A068UTQ4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033999001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739141">
        <property type="protein sequence ID" value="CDP11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTQ4"/>
    <dbReference type="Gramene" id="CDP11624">
        <property type="protein sequence ID" value="CDP11624"/>
        <property type="gene ID" value="GSCOC_T00033999001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTQ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658243" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7165" checksum="90DE05F85197FB62" modified="2014-10-01" version="1">MITGDFPGRWLAMVGLSLLLQPGSRFFRGATSRMRTNACKTNACESLCNTQVNVFLTEAYYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UW59</accession>
    <name>A0A068UW59_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poor homologous synapsis 1 PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037393001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739154">
        <property type="protein sequence ID" value="CDP12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UW59"/>
    <dbReference type="Gramene" id="CDP12755">
        <property type="protein sequence ID" value="CDP12755"/>
        <property type="gene ID" value="GSCOC_T00037393001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UW59"/>
    <dbReference type="OrthoDB" id="1864854at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UW59"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057619">
        <property type="entry name" value="PH_PHS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25349">
        <property type="entry name" value="PH_PHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poor homologous synapsis 1 PH" evidence="2">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="182" mass="20656" checksum="D135D99C56CD8530" modified="2014-10-01" version="1">MDPGEIQPEQQQQTLALKLQFQIDYSVFFNYTTTSSYQNSRSLLQKEKNNNYNQVDERLIPHTKKRGRSKGGAWLSSSSSSTASLFLFRYTCHSPLVLLISLAGRIQEEHFISKLHFSWLQLSCASGSRVVLASYKDSVGQASFHTLIIQKFAMRFVNSLESQSFIESLKVKLSSAVCFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWT5</accession>
    <name>A0A068UWT5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037747001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWT5"/>
    <dbReference type="FunCoup" id="A0A068UWT5">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWT5"/>
    <dbReference type="Gramene" id="CDP13015">
        <property type="protein sequence ID" value="CDP13015"/>
        <property type="gene ID" value="GSCOC_T00037747001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWT5"/>
    <dbReference type="OMA" id="NCEEARW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWT5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF546">
        <property type="entry name" value="CARBOXYLESTERASE 120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="86"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="37329" checksum="96F4278DC3304990" modified="2014-10-01" version="1">MADKITEFPPGNPQTDPYGFLGFVRNPDGSVARILDMPKTPVSSFDKSPVLLVKDIPVNPSKNTFVRIFLPRKAIESSPGTKLPLLIFIHGGGFVICSAATPYFESLYNSFTVDIPVVMVSIEYRLAPEHRLPAAYEDCMEVMQWIKSPQDEWLTKYADLSNSFLMGSSAGGNIAYHVGLSASSCVDDLKPLEIKGLILHQPFFGGTKRTESELRADNDKILPPCVTDVMWELSLPVGVDRNHEFYHGFCNPVLSIKPGQFDHIKDLGWKILVTGYDGDPLFDRQVELVKMLEDEGVPLAAKFAQGGYHGIDGFEPPKLKVLCQVVKEFMISFVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXJ8</accession>
    <name>A0A068UXJ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038102001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXJ8"/>
    <dbReference type="FunCoup" id="A0A068UXJ8">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13230">
        <property type="protein sequence ID" value="CDP13230"/>
        <property type="gene ID" value="GSCOC_T00038102001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXJ8"/>
    <dbReference type="OMA" id="VRWRELF"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXJ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF27">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="47263" checksum="D0599FBE5A3DB3D8" modified="2014-10-01" version="1">MWSLSKFWEKVCKVAEGGSHYCSKKSDDNCGGASDEDSGRALSMTRLKCILRGLDLKTYIFLLILIPTCVFFIYVHGQKITYFLRPLWEKPPQPFHEIPHYYHENVSMENLCRLHGWGIREYPRRVFDAVLFSNEIDLLTVRWKELYPYVTEFVLLESNSTFTGLPKPLVFNSNREQFKFVESRLTYGQIPGRFRKGENPFIEEAYQRLALDYLLKKAGIQDDDLLIMSDVDEIPSRHTINLLRWCDDIPQVLHLRLKNYLYSFEFFVDNNSWRASIHRYQSGKTRYAHYRQAEVILADAGWHCSFCFRHISEFIFKMKAYSHFDRVRFSHFLNPKRVQRVICKGADLFDMLPEEYTFKEIIGKMGPIPHSYSAVHLPAYLLESADKYRFLLPGNCMRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXM8</accession>
    <name>A0A068UXM8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00037817001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXM8"/>
    <dbReference type="Gramene" id="CDP13057">
        <property type="protein sequence ID" value="CDP13057"/>
        <property type="gene ID" value="GSCOC_T00037817001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXM8"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXM8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000394">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994:SF5">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="328" mass="36755" checksum="241E2D1F5597DC92" modified="2014-10-01" version="1">MVRPPEKGVKKGPWSIEEDQRLVEYIEKHGQGNWQTLPKQAGLNRCGKSCRLRWTNYLRPGIKRGGFSAEEEAAIIALHKQLGNKWSRIAAHLPRRTDNEIKNFWNTHLKKKLLRRGIDPTTHKPVPDFSLLNLSQAQLLSVSDLHNFINPLDAALNLQANANDLIKFQLLKNMMQAINPNPLPYIQGNTNLADLIQLNRLFDGTNTDFTVDPLQAQSMNTSFCNISPLLNQQQTSTSHSLPCLDGQITPGPILDDGFNVSSSNMYNSEYSLPSLVSVTPESSIINPFESFKHGSIPAEAPEQSNVFDDWNSLVNDEASSLFWKDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXP9</accession>
    <name>A0A068UXP9_COFCA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037849001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXP9"/>
    <dbReference type="STRING" id="49390.A0A068UXP9"/>
    <dbReference type="Gramene" id="CDP13077">
        <property type="protein sequence ID" value="CDP13077"/>
        <property type="gene ID" value="GSCOC_T00037849001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXP9"/>
    <dbReference type="PhylomeDB" id="A0A068UXP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="19547" checksum="2CDEA8F26A0C2E2A" modified="2014-10-01" version="1">MTPKALTFGYLSCRIGFSQRTAIASLLYWFLAVSSLKGRKNTFEKIEEAIDYVNEQLPSDDSSVPAAPDPNLKNATDRNEAQIPSELITQCVATLLMIQSSIAEMYREAVSTSRCGSNIGFCSYKLEALLPTKPSSLYRNTEVHGNCQEPNIGAYTYLANKTWKFFFFLVCNVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYN4</accession>
    <name>A0A068UYN4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00038516001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the targeting and/or fusion of transport vesicles to their target membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Prevacuolar compartment membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYN4"/>
    <dbReference type="FunCoup" id="A0A068UYN4">
        <property type="interactions" value="2090"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYN4"/>
    <dbReference type="Gramene" id="CDP13536">
        <property type="protein sequence ID" value="CDP13536"/>
        <property type="gene ID" value="GSCOC_T00038516001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYN4"/>
    <dbReference type="OMA" id="HYENRIV"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000008">
        <property type="entry name" value="Vesicle-associated membrane protein 711"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655236" evidence="12">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="220" mass="25207" checksum="6D2E831CD4CA37B6" modified="2014-10-01" version="1">MAILYALVARGSVVLAEFSATSTNASSIARQILDKIPGNNDTNVSYSQDRYIFHVKRTDGLTVLCMADDVAGRRIPFAFLEEIHQRFVRTYGRAVLSAQPYAMNDEFSRVLSQQMEYYSHDPNADRINRLKGEMSQVRNVMIENIDKVLERGDRLELLVDKTANMQGNTFRFRKQARRFRSTVWWRNVKLTIALILLLLVVIYVVLAFVCHGLTLPTCLK</sequence>
</entry>
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    <accession>A0A068UZU2</accession>
    <name>A0A068UZU2_COFCA</name>
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        <submittedName>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
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                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
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                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">cv. DH200-94</strain>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="166" mass="18125" checksum="C84961D21AAAA3F5" modified="2014-10-01" version="1">MTAISVRIAALEALEALLNGWRSNIDRLLITVATNACKVGWANNNSTVVYGEATPVWADFQLAALRALLASLLSPGCVRPPHLAQGLELFRRGNRESGTKISEYCCHALLTLEVLIHPRALPFIDIQSAVDHYGSASLNLPDVHFAVHRKNTSFHFSTLGKEPSQP</sequence>
</entry>
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    <accession>A0A068V0W9</accession>
    <name>A0A068V0W9_COFCA</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040381001</name>
    </gene>
    <organism evidence="11 12">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
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            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Lan T."/>
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                <person name="Leroy T."/>
                <person name="Li L.T."/>
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                <person name="Perrotta G."/>
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                <person name="Zhang Q."/>
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                <person name="Giuliano G."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">cv. DH200-94</strain>
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        <property type="gene ID" value="GSCOC_T00040381001"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="576"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="779"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="944" mass="103378" checksum="0219D60EAEE7C664" modified="2014-10-01" version="1">MATAEAAPASLGPRYAPEDPTLPQPWKGLIDGSTGVLYYWNPETNVTQYEKPTAVAPPLPPGPPPSASTPTLAPIPGARTTQASEVQNQQMQAQQQVQQVNPHLQQQQQQQALISPHIVQRHSSQIPPTGQQQGSQLVPSVEQQGQLTPQHLRPQMLQYVGQSTPSQSGQVQVPPGSHAPQQPMQQMGQQTLMYQGPPGGNPQTHQFPHQQTQYMPYQQNVLQHGHQNSQQQTLQRHHFSHQQDHKMGFPPREDIDSQQGKQVGHSPAQIQSSASSSIQNLPAGSSSMQAPQMGVQPNQATQFGGSSVNMQQPASLLQLQQGAMDLLQPQHGSRFQNQMGPSMMHAQQPKGPPFGPNVGYDGSPLGRAGNDLYYNSNKDGHVMAPQQPKLAAIPMARNNQEMRRGDVHLQNVVPSHPGGLSGVTGPPMHDLYGHATGGPLFPNDSFTRPPPGIIGPSDANATHLSPADVYRQKHEVTATGDNVPAPFMTFEATGFPPEILREVSAISAPQEEHMSYAAVLMLILTPQLFSVFEAAKWTVGAFLGSFLKGGWPFIHITIFIQLAGFSFPTPIQAQTWPIALQSRDIVAIAKTGSGKTLGYLIPAFMHLRRLHNNPQYGPTVLVLAPTRELATQIQDEAIKFGRSSRVTCTCLYGGASKGPQLKELERGADIVVATPGRLNDILDSKRIDFRQVSFLVLDEADRMLDMGFEPQIRKIVNEIPPRRQTLMYTATWPKEVRKIANDLLVNPVQVNIGSVDELAANKSITQYVEVVPQMEKQRRLEQILRSQERGSKVIIFCSTKKLCDQLARSIGRNFGAAAIHGDKNQGERDWVLNQFRSGKTPILVATDVAARGLDIRDIRVVINYDFPTGIEDYVHRIGRTGRAGATGVSYTFFSEQDWKYAADLVKVLEGADQQVPPEVKDMALRGAPSFSRDRGIVALVAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1I4</accession>
    <name>A0A068V1I4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein TIC 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00038757001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in protein precursor import into chloroplasts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Plastid</location>
            <location evidence="7">Chloroplast membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Tic20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1I4"/>
    <dbReference type="FunCoup" id="A0A068V1I4">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1I4"/>
    <dbReference type="Gramene" id="CDP13718">
        <property type="protein sequence ID" value="CDP13718"/>
        <property type="gene ID" value="GSCOC_T00038757001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1I4"/>
    <dbReference type="OMA" id="IFACLPY"/>
    <dbReference type="OrthoDB" id="414558at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1I4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005691">
        <property type="entry name" value="Tic20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510:SF11">
        <property type="entry name" value="PROTEIN TIC 20-V, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16166">
        <property type="entry name" value="TIC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="4" id="KW-1001">Plastid inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="223" mass="24877" checksum="34AA4E10D6FA62AB" modified="2014-10-01" version="1">MATTILLSATVTPSLIHLHKPPLYSTIFSSSSSNPRIPSQLSIFHLTSPSKRSNFSRRNLVKAQSKGSNSADAPDRLISAICYFFPFFDGIQYGKYVITQFAPVQALVQPLVPAIKVFKAFPLNGFLVFLTLYFVVVRNTNFSRYVRFNTMQAIVLDVLLIFPDLLERTFNPRDGVGLDLLMSFDSTVFLYLLVCLIYGSSSCLLGQLPRLPLVAEAADRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1N7</accession>
    <name>A0A068V1N7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00040852001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="632" mass="71016" checksum="945E2709D269F992" modified="2014-10-01" version="1">MNDTGNFVLKGRDNSSLWESFSFPADTILPLQELETGSVLNSRHSETNFSQGRFSLRFLDNGDLVLTARTLPNTTYDDVVYYDSQTSKPTNTSNSGYRLVFNRSGIISIVTSNNQTEQIGSPTLFPPVSEDYFRATLASDGILASYYHPRNSTGNQNWTVLWSKPDDICETAAAATGSGACGYNSICNLVNGRPVCECPDGYTLLDPNDKYGSCMPNYTQSCDEVEQGTAGELYDFVVINGADWPFSDYQVMTPSTEVGCREACLHDCFCAAAIFRNNTCYKKKLPLSNGWNSGVLNPVALLKYRKTCSGFYLIYKKNIVKSHPNGETNLRYFTYKELVEATNGFKEELGRGSFGIVYKGELQISSKSSAIAVKKLDRVAQDTEKEFRAEVNTIGQTNHKNLVRLLGFCDEGQNRLLVYEYMRNGTLSSFLFTTPKPSWKLRTQIAMGIARGLVYLHEECSTQIIHCDIKPQNILLDDYYNARISDFGMAKLLVMNQSRTLTNIRGTKGYVAPEWFRNTQVSAKVDVYSFGVLLLEIICCRRSVEDIESVEEGYAILTDWVWDCFQERRLDTLVENDSEALNDKTMLERFVKVGIWCVQEDSSIRPKMRKVSQMLDGIVEVMVPPCPSPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1W5</accession>
    <name>A0A068V1W5_COFCA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041082001</name>
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>asterids</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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    </reference>
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        <property type="component" value="Chromosome XI"/>
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        <property type="entry name" value="Chloro_ReproSupport/MetalTrans"/>
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        <property type="entry name" value="CHLOROPLAST PROTEIN FOR GROWTH AND FERTILITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNNAMED PRODUCT"/>
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            <begin position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CDP14557.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="391" mass="41724" checksum="E1F0EADBC82CA858" modified="2014-10-01" version="1">MEKLLCYNPIPSKFHLKRITFLPQPPRLSTTIPAAHFNRLTYFLPDSSRVNSFSCNYQHSSSNSFAISSKSADTADHCTHNLSSASVDRPDGSTEKVNFFRKDVKSLPQQQKVIAAGTVMLLSAIFMTVIHPMVASPAFASFQSAAKAGGPTAAAVGMQLLKNELVNSAWTGFLAGCLHTLSGPDHLAALAPLSIGRTRIESAAVGALWGCGHDAGQVIFGLMFLLLKDRLHIEIIRTWGTRVVGFTLMVIGAMGIREASEVPAPCVALENGECDVSIYEGLENPTIGKKKIGLATFATGIVHGLQPDALMMILPALALPSRVAGAAFLVMFLVGTVVAMGSYTVVIGSCSEALKDRVPRITEKLTWASSLVAIALGLAILISQFFGFSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V328</accession>
    <name>A0A068V328_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zer-1-like leucine-rich repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042496001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739177">
        <property type="protein sequence ID" value="CDP14977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V328"/>
    <dbReference type="Gramene" id="CDP14977">
        <property type="protein sequence ID" value="CDP14977"/>
        <property type="gene ID" value="GSCOC_T00042496001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V328"/>
    <dbReference type="OMA" id="NYESIGE"/>
    <dbReference type="OrthoDB" id="2018313at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V328"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF61">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="3">
        <location>
            <begin position="91"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="464" mass="52218" checksum="36258D50EB593DCE" modified="2014-10-01" version="1">MTLTVLEVSGSGLVKSMPKNFFQHLKKLRSLHFSDFQIEVMPASFYHLTELSWLILKRFSHLTKLQSLKECQNLMVVDLSGAASLPTFPEKNLKSLPKLQTLNLSNSKIKSLPIFHETGELTHLSVSGCSNMDRVPSIRSLTNLQVLDLSWSTIVEFQDKSFQNNTSLKILDLSGTAIPSLPFNIGKPREFYLKNCSEIKYMNCVESSEELEILDFSGACNLVKIEGKFFECLENLRVLNLSGTKVKDLPSLSALHNLRQLLLSCCLNLEKLPRLTSSKLEELDLSDCKAMTMIEDKSFEHLPRLRRLVLSQTKIVHLPELNSLSNLEELNLSGVKSFTGTDFIEHMSKLQVLNLSETLLKELPALTNLKSLKHLFLRGCGQLEVLPVLEVLHNLETLDLSQTALRQLPFVGSLSNLHKLLLSDCSKLENFKNHKLLDMSGVENLPCGISRLTQLQHLALPGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3S5</accession>
    <name>A0A068V3S5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041056001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3S5"/>
    <dbReference type="Gramene" id="CDP14538">
        <property type="protein sequence ID" value="CDP14538"/>
        <property type="gene ID" value="GSCOC_T00041056001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3S5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="130" mass="14421" checksum="860ADB2D7C32EB07" modified="2014-10-01" version="1">MRLPNSSLIRSLFFLDFGSFVPQVTRRLNPSSSSSSPLCYVRELGLEWTGLSRVSCLGGEGSRVGAGGQKEKGEEPDRKRKGEKNKRVRESEVSEIRVDIESLRGFGESEGPRALVYRRHVSEPGILPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3Y9</accession>
    <name>A0A068V3Y9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042940001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739181">
        <property type="protein sequence ID" value="CDP15272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3Y9"/>
    <dbReference type="FunCoup" id="A0A068V3Y9">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3Y9"/>
    <dbReference type="Gramene" id="CDP15272">
        <property type="protein sequence ID" value="CDP15272"/>
        <property type="gene ID" value="GSCOC_T00042940001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3Y9"/>
    <dbReference type="OMA" id="CIRATTQ"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3Y9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF4">
        <property type="entry name" value="PROTEIN BOLA4, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17869" checksum="18111040308A101A" modified="2014-10-01" version="1">MALLTQPNAVTLWVCRCRLFCCRTLVSLPARREGRHFSALIFSNVKCSSCIGLTAVPVVSRRQFCVRVATGVNDFGSVDSTLTQSMGRKIKEQLNAESVIVKDSYGDGRHVSIDVISTTFEGQSVVGRQRMVYKALWEELQNTVHAVDQMTTRTPVEAAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5V9</accession>
    <name>A0A068V5V9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription repressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ovate family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00017231001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional repressor that regulates multiple aspects of plant growth and development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00017231001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5V9"/>
    <dbReference type="OMA" id="HMVILEA"/>
    <dbReference type="OrthoDB" id="1928390at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5V9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Ovate"/>
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        <property type="entry name" value="A_thal_3678"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057:SF17">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OVATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OVATE" evidence="8">
        <location>
            <begin position="345"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="170"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="261"/>
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            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="163"/>
        </location>
    </feature>
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            <end position="246"/>
        </location>
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            <end position="261"/>
        </location>
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        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="408" mass="45841" checksum="24C6FEEFBB4480F2" modified="2014-10-01" version="1">MIHTLCDSYTFNILATSQKSIQTSCDQLKSVMDHHPVKRVSRFFPSSLTSCQFRSVPDVVQSSVPVKKGTKFLHHEIEPPIPSSDIHKRPSVIKSQEPKTTLKKGKEASKHYQKKPLLMGSDPEGRRRPAVKPVSVMDSKKKERAKETKMNYSISSSNSTGRWFSSDDEAADDQCDGKSDTFLSLSSCTSSESFRLKSAKIHSKRFDSKMSTELGRCSSALTAYSLNAALSPCSQKTTKSGSNTAQKHGKSTRRDSKTDKTWHRWETDDDDFVIDNEILKGCQVSEASAELYYDGSGSHHCRKSTKSRRKTSKKHRGKKGQIKSDKDGQLLNAVVEDGVEDAYAVEKSTSDPYNDFRTSMLEMIIEKQIFGVKDLETLLECFLSLNSPYYHMVILEAFTEICDTLFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V620</accession>
    <name>A0A068V620_COFCA</name>
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        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
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        </cofactor>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
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    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 83B1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012791221" description="Cytochrome P450" evidence="14">
        <location>
            <begin position="16"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004167"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP16106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53389" checksum="8A4ABE0675301B1F" modified="2014-10-01" version="1">MAWLFLCSILPLILIFLLQKTKKSKKTRGPPGPPGLPFIGNLHQLDSAKPHEYLWKLSKKYGPLMSLRIGSVPVVVISSSKMAKEALKTHDLVFSGRRAYVSHQKLSYNGRDVAFSPYGEYWRQMRKVCVLHLFSLSRVQSFSPIIQDEISHLIQKISNLSCASKVINLSSIMTSLGSTIICRIAFGFFISDYLPSLSWIDKLSGMFARLEKNFKDLDLFYQEVIDEHLNTNRPETMKDDVLDILIQIKQEQSSGFELTWDHIKALLMNIFIAGTDTSAATVVWAMTALMKNPSALKKVQAEIRDLVGQKGAVVGEKLQQLRYLDAVIKEALRLYPPAPVLVARETTQSCNIEGYEIGSKTLVYINDWAISRDPESWERPDEFIPERFLNNAIDVRGNDFEVIPFGAGRRGCPGIHLGLSTVKLALANLLYSFEWELPSGIRAEDIDTDVLPGITMHKKNALCILAKEYLHKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V762</accession>
    <name>A0A068V762_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M41 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00018247001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739207">
        <property type="protein sequence ID" value="CDP16392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V762"/>
    <dbReference type="STRING" id="49390.A0A068V762"/>
    <dbReference type="MEROPS" id="M41.A06"/>
    <dbReference type="Gramene" id="CDP16392">
        <property type="protein sequence ID" value="CDP16392"/>
        <property type="gene ID" value="GSCOC_T00018247001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V762"/>
    <dbReference type="OrthoDB" id="2016403at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF19">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 12, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M41" evidence="7">
        <location>
            <begin position="272"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="41725" checksum="E27CA84BF758F85D" modified="2014-10-01" version="1">MEISTLNYAAGGHPFQLSSTSTPPTITAKQHLLLSPNTPPPSSTLSNFFLLPVSRPFAPFSRFTYMSKLSCHKKSQRTPILASSSSSSDSTSNDNPLDHSASDAAAGFSWLHLSRRFFTNFKQQTGIDFQHDTIAALARLTAPLRRSVQLPHSALERFRSHLLADFVNWNKLDCWKDVKNWEAKRIGVLILYALVMVVSSQGIYKAIQAPVIDRERRELAEAYMEALIPEPTPTNVRKFKKGLWRKTTPKGLKLKKFIEGPDGTLVHDSSFVSFEKKRLLAVHEAGHIVLAHLFPRFDWHAFSQLLPGGKETAISVFYPREDMVDQGYTTFGYMKMQMVVAHGGRCAERIVFGDDITDGGQDDLEKITKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8X3</accession>
    <name>A0A068V8X3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00007171001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739227">
        <property type="protein sequence ID" value="CDP17012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8X3"/>
    <dbReference type="FunCoup" id="A0A068V8X3">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8X3"/>
    <dbReference type="Gramene" id="CDP17012">
        <property type="protein sequence ID" value="CDP17012"/>
        <property type="gene ID" value="GSCOC_T00007171001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8X3"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8X3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000083">
        <property type="entry name" value="Mitochondrial substrate carrier family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000113">
        <property type="entry name" value="Mitochondrial substrate carrier family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP17012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="365" mass="40404" checksum="2B8C2942CC8FEA91" modified="2014-10-01" version="1">MVDPNPSSSNQPFTLSTTKTSASTQNHFFVWREFLWGAIAGAFGEGMLHPVDTIKTRIQSQAVLRGCRNQKSILQMVRTVWATDGLTGFYRGITPGVTGSLATGATYFGVIESTKKWIETSHPNLGGHWAHFIAGAIGDTLGSFVYVPCEVMKQRMQVQGSKKYWSSVVMKGSAHMKHGNPMYGYYSGLYQAGCSIWKEQGLKGLYAGYWSTLARDVPFAGLMVTFYEAFKNVTEYGRQRLFPDSNRCPNSSIEGLLLGGLAGGLSAYLTTPLDVVKTRLQVQGTTLRYNGWLDVIQKTWSTEGIRGIFRGSIPRIMWYVPASALTFMAVEFLREHFNDGVNDDKLKEVASLSIDKNASSFQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA65</accession>
    <name>A0A068VA65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="3">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">10-formyletrahydrofolate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Formyltetrahydrofolate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00013211001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="3"/>
    <dbReference type="EMBL" id="HG739256">
        <property type="protein sequence ID" value="CDP17670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA65"/>
    <dbReference type="FunCoup" id="A0A068VA65">
        <property type="interactions" value="2836"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VA65"/>
    <dbReference type="Gramene" id="CDP17670">
        <property type="protein sequence ID" value="CDP17670"/>
        <property type="gene ID" value="GSCOC_T00013211001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA65"/>
    <dbReference type="OMA" id="KFWNLKC"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA65"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1510.10:FF:000003">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="634" mass="67440" checksum="6550857FCC12D7E9" modified="2014-10-01" version="1">MGKTVRKLQVVSPVPADIDIANSVEPLHISEIAKELNLSPQHYDPYGKYKAKVLLSVLDELQGSEDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCLRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQTDKGLFNRLCPPDKEGKRSFSNIMFRRLTKLGISKARPEELTPQEIKKFARLDFDPSSITWRRVMDINDRFLRKITVGQGPEEKGMVRETGFDISVASEIMAVLALTTSLADMRERLGKMVVGNSKAGDPITADDLGVGGALTVLMKDAINPTLMQTLEGTPVLVHAGPFANISHGNSSIVADKIALKLVGRGGFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAVIVATIRALKMHGGGPEVVAGKPLDHAYLTENVALVEAGCVNLARHISNTKAYGVNVVVAVNKFATDSEVELNAVKAAALSAGAFDAVICTHHAHGGKGAVDLGVAVQRACENIAQPLKFLYPLDMSIKEKIEAIAKSYGASGVEYSEEAEKQIGMYTKQGFGSLPICMAKTQYSFSHNAAAKGAPSGFVLPIRDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTTTGRVIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD58</accession>
    <name>A0A068VD58_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00002679001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739362">
        <property type="protein sequence ID" value="CDP18745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD58"/>
    <dbReference type="FunCoup" id="A0A068VD58">
        <property type="interactions" value="1020"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VD58"/>
    <dbReference type="Gramene" id="CDP18745">
        <property type="protein sequence ID" value="CDP18745"/>
        <property type="gene ID" value="GSCOC_T00002679001"/>
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    <dbReference type="InParanoid" id="A0A068VD58"/>
    <dbReference type="OMA" id="NFPCSAS"/>
    <dbReference type="OrthoDB" id="1893746at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000217">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase At1g53430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000452">
        <property type="entry name" value="Probable LRR receptor-like serine/threonine-protein kinase RFK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000004">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000958">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF68">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
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        <property type="match status" value="3"/>
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        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655812" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="27"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="677"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="982"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP18745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112413" checksum="1DFF2463FCAD45F5" modified="2014-10-01" version="1">MLAKMLPFLFLICSFQLVFFANSAFAATPATLLRQEVLVLKEIAKGLGKTDWDFSIDPCSGKGNWSLPILVKGIESSVTCDCSFNKNSSCHITGIALKAQNLSGTVPPGFAKLQYLAHLDLSRNNLHGSIPPQWASMKLVELSLMGNRLSGPFPVALTRITTLVNVSIEGNLFSGHIPPEIGNLVNLQKIILSSNSFTGELPVALSKLSNLTDLRVSDNNFTGKIPDFIGSWKKIEKLLMQGCYLEGPIPSSISALTKLTDLRISDLKGKGSPFPDLSNMESMKTLTLRQCSIYGEIPKYIGDMQKLKNLDLSFNNLTGEIPATFVQLSKVDFMYLTGNRLTGPIPDWILSRNKNVDVSNNSFTWESSSPIECPRGSVNLAESYSSKNKFPSRVHSCLMQNYPCPEPRDQQHYSLHINCGGKDFIATNNTKFEADLEARGASMFYAGQNWAFSSTGNFMDNDIDSDIYIHTNTSALQNVSSAESQLYTTARVSPLSLTYYGQCLINGNYTVKLHFAEIIFTNDSTFNSQGKRIFDVYLQENLVLKDFNIENEAGGPGKPIVKTITATVTSHTLKIHFYWAGRGTTGIPVRGVYGPLISAISVDPNFEPPSTHRRKIEAVTVLGVVAGALLAVILILAILRRKGYLGGKISAEKELRGLDLQTGIFTLSQIKAATKNFDPANKIGEGGFGSVYKGQLSDGTVIAVKQLSSKSKQGNREFVTEIGMISALQHPNLVKLYGCCVEGNHLMLIYEYMANNCVSRALFGKDSASKIKLDWPTRRKICLDVARGLAYLHEESRLKIVHRDIKTSNILLDKDLNAKISDFGLAKLNEDDCSHISTRIAGTIGYMAPEYAMRGYLTAKADVYSYGVVALEIVSGKSNTNYRPKEECVYLLDEAYVLQERGSLLELVDPDLGSEYSSEEATLMLNVALLCTNASPTLRPTMSQVVSMLEGQTDVQDILSEPGFSTAPSRFKNVRSHFWQNASPSQTQSISSSGPHSYSSRSNADIEENRTFQRVSNSEHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEY5</accession>
    <name>A0A068VEY5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00001650001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739445">
        <property type="protein sequence ID" value="CDP19147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEY5"/>
    <dbReference type="FunCoup" id="A0A068VEY5">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEY5"/>
    <dbReference type="Gramene" id="CDP19147">
        <property type="protein sequence ID" value="CDP19147"/>
        <property type="gene ID" value="GSCOC_T00001650001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEY5"/>
    <dbReference type="OMA" id="ESPPYFN"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEY5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04592">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 12" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="679"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="811"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP19147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="956" mass="103286" checksum="46F6CA2A5E97C6C0" modified="2014-10-01" version="1">MMGFLSTTKPISSIDQCLCCYSCCNAFFFLRPRIIPSSTPLPPPPYPISMLNSSSTRKSLVVRHSSKESSALVMSHSQNATTKLNIARRRRRRSLLVFCNTNGGNSNEDENDGGPGREAEEEIIEEAEVVSPENKAIINACLVGLFTGIGVVLFNIAVDEIRHVFWDGIPDRGASWLREEPIGVKWGHVILIPACGGLLVSMLKLFQTAIEEPKNWNLSSNVKATLDPIFKAVAACITLGTGNSLGPEGPSVEIGASIAKGVGTLFDNSSQGKLSLKAAGSAAGIASGFNAAVAGCFFAVEVVLWPSPAESSSSLTNTTSMVILSAVIASVVSEIGLGSEPAFIVPNYEFRSPSELPLYLLLGTVCGLVSLTLSQCTTFMRVAVDNIEKITGVPNTIFPIFGGFTVGLMALAYPEILYWGFENVDLLLESRPLVEVLSVNLLLQIVAVKILATSLCRASGLVGGYYAPSLFIGAATGMAYGKVVSFVFSQSNPIFHLPFLEVASPQAYGLNCLLKTKPAACANDKKKKRKKNKNSFKIFVVMPYVARCCKLLAFLATVLAFLYCAPFVVIKQIQLHITESKPAALASLELPLQKLDIVNLLKSSHAFLSFDPLDVDGHCLMSNCLGLKIAKVYCYSCFWASHAFFFSITSSLELLLLYDQCTLGIIMRKIISWLWIKQHNIVSIIVGMAATLAGVCQVPLTAVLLLFELTQDYRIVLPLLGAVGLSSWITSGQTRRKGVVGTKKVNNENAFLNQQPEISSSSSPLVSSANSVVEKASDESNIGELGRLLYLGEPNDNTNGIMQRILVAQAMRTRYATVMMSTSVAEAVSLMLAEKQSCAAIVDDKDLLIGLLTLANIQQFTELSKAKTKSPKELTVSEVCAPEGEECQIPLSVTPNMSLLSAQTLMYRHRMSQVPVVQDQGHPVGLLDNECISLICRGLAIGECLQQFPTLERLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF20</accession>
    <name>A0A068VF20_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012012001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF20"/>
    <dbReference type="STRING" id="49390.A0A068VF20"/>
    <dbReference type="Gramene" id="CDP18283">
        <property type="protein sequence ID" value="CDP18283"/>
        <property type="gene ID" value="GSCOC_T00012012001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF20"/>
    <dbReference type="OMA" id="CNIKWKP"/>
    <dbReference type="OrthoDB" id="1308at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF20"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02969">
        <property type="entry name" value="PRX_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047262">
        <property type="entry name" value="PRX-like1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43640">
        <property type="entry name" value="OS07G0260300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43640:SF1">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="252" mass="28519" checksum="2038FD92409B7188" modified="2014-10-01" version="1">MAGIVTATQSFITAPPRLLCRRQPQIIKHNLFSFLFFSKMGFDSFQKSFNFPVRKLVIRAAGAESKGVSLGFRAPHFELPEPLTGKMWKLEDFEPYPALLVMFICNHCPFVKHLKKDIVKLSNFYVKKGLAVVAISSNSTVTHPQDGPEFMGEEAKLFKYPFPYLYDETQDVAKDFGAVCTPEFFLFRKDGRRPFELVYHGQFDDSRPSNDVRVTGRDLSLAIDCVLSGQPVSSDQKPSIGCSIKWHPKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF43</accession>
    <name>A0A068VF43_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00002173001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739584">
        <property type="protein sequence ID" value="CDP19455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF43"/>
    <dbReference type="Gramene" id="CDP19455">
        <property type="protein sequence ID" value="CDP19455"/>
        <property type="gene ID" value="GSCOC_T00002173001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF43"/>
    <dbReference type="OMA" id="ASHQEME"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="175"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="440"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="560"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="957" mass="109176" checksum="A0899C031B274C9C" modified="2014-10-01" version="1">MAVTILSSVLNQLSILLLEEGQLLGGLRQEVELIRDELGHMRAFLRVAEIEEEDADPRLQEWTKQVREAAYDIEDVLDEFLACFARHPATGFHGSVRRIFNSIKTLRARHKVAEQIQSIKARVKNISEGHQRYRLEFGVATQVSGSPAAVNNTTWRHSRDEAILVEEAELVGINKPKQQLVSQLLEGDESQLKVVSVVGMGGLGKTTLVKKVHEDLDVRRHFPVRAFVTVSQTCNFQELLKDLIRQLHNELKKPVPESIEAMTAIQLKQCVKDFLQQAGRYAIVFDDVWDTKFWNAIRIALPKNGYGNRVMLTTRKADVAFASCTQSQDYVFKMVPLSFEDSWTLFCNKIFKGNGCPAHLTDVAKGILGKCEGLPLAILAISGLLALKDLNIAEEWKMVRCSLGGELEGSGMLDKVRKILSLSYNDLPCHLKTCLLYLSIYPEDFEIGCHRLVQLWTAERFVEKREEMTLEDVGYNYLKELVNRSLIQVSESFYEGIPYSCRIHDLVREVILSKSREQYMVAITTGQYTRWPSSKARRLVVHNSNHTQQHQESQYYCFDHLRSFIAIGSMNPLVSKNLLPKVLRSGRLLKVLDLRGEKTLEDIPNEIFHLCRLRYLNLYGTGIKAIPKSIGKLRNLEYLNLSDTQVRELPMEILKLQKLQHLRVFKLVDPLDHNYGFRGFMAPSKLGGLFALQSLFGIDASESIIVKEIGKLTELRELGISNLRREDGKELCSSLANLTSLRELTVSSIRKDDDDYEVMNLNHHHQQHSNSSSVSSSFLVSLRMLVLSGCLEKMPWWIAHLQSLVRIDLNWSSLSEEEDPLESLHHLPNLGAVQFCGSYQGEGLCFKAGGFLRLKTLYLKKIDKLRWMKMEEGALPSLQEITLVELPLMQALPWGIEHLSHLQKLRLYQLSSQLTRNLVDQNEESEDYTRIAHIPEIVIGFLSNKGWNEHRLWGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGH9</accession>
    <name>A0A068VGH9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00001462001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739801">
        <property type="protein sequence ID" value="CDP19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGH9"/>
    <dbReference type="STRING" id="49390.A0A068VGH9"/>
    <dbReference type="Gramene" id="CDP19821">
        <property type="protein sequence ID" value="CDP19821"/>
        <property type="gene ID" value="GSCOC_T00001462001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGH9"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGH9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="3 13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11 13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5 13" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="18514" checksum="5FA2E6C07DA8CC68" modified="2014-10-01" version="1">MLGALGCITPEVLEKYLKVDFKEPVWFKAGAQIFSEGGLDYLGNPNLVHAQSMLAVLGFQVVLMGLVEGYRINGLEGVEEGNDLYGGQYFDPLGLADDPVTFTELKVKEIKNGRLAMFSMFGFFVQAIVTGKGPLENLLDHLDNPVGNNAWSMPPSLSPDRKVFLLCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGI9</accession>
    <name>A0A068VGI9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00005579001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739372">
        <property type="protein sequence ID" value="CDP18803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGI9"/>
    <dbReference type="FunCoup" id="A0A068VGI9">
        <property type="interactions" value="1140"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGI9"/>
    <dbReference type="Gramene" id="CDP18803">
        <property type="protein sequence ID" value="CDP18803"/>
        <property type="gene ID" value="GSCOC_T00005579001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGI9"/>
    <dbReference type="OMA" id="IVHYKKP"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGI9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="81689" checksum="99D173EA1FDD32DE" modified="2014-10-01" version="1">MRYVLNDFFFFFLVVNFSREKEKKKKRRRRNRFQFQTITICKYFFSIYSFRTGQPQKYKRAKGLRLLASGSKLLCSPLPLCGTAGGGYFSNFLEEVETSGGGPPAQSAAQPSGNSHSPLLDDCLKLLRGERDEQRLAGLLLVTKFCNKQDHSTILQVYRAVGPKFLLRLLRTGMGKVGGGGGGGAENRDAYLQLSVTVLAAFCRVPEIAASQDMLSLIPLFQEIISTGSASSVIEDCYEFVYLVANTHEDGVRALYDSGSMQLLASQLSTLPDGSPIVELAMRLVQLIISRLPAEKVFIEHPSELAILVVGLARLFALLQTALKFEALHLLSAILSSQCSAPVRGALNSMANSTWSTDMRVGIVAVLNNRVAPAEKLQALILAECTISIVGEEWLIGSVKLPDVQDPIPVDRCMLLVLGTSRVEIAVLLNELARLRDEASKSHSLNAEVIHMKQRNLAICYSLVEKVIKLVSKFGGDEDLHPDATISDSTLTMIISGLNETISVVLDYLEDVKDHGENKGDDLLASVRLIGSYLAETPHACGEKVKALLGYMLSIQGEDEASPFYSICFLIPMLCQITMRTDGCKLLASSGAYGAVIEYLIRLIAPTSSTVEDAGSVSLACDTILNFLMKREQIAFTFSGASFIKLLSALSHWTEDRGDPDSLMMASSICALILDSISEETLIRHPDLSNDDLVSLSQLMKRSLAMCGKGMMSDEESDLYQIVHACYLRWVDRFPRIKELIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK44</accession>
    <name>A0A068VK44_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00008184001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741510">
        <property type="protein sequence ID" value="CDP21071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK44"/>
    <dbReference type="STRING" id="49390.A0A068VK44"/>
    <dbReference type="Gramene" id="CDP21071">
        <property type="protein sequence ID" value="CDP21071"/>
        <property type="gene ID" value="GSCOC_T00008184001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK44"/>
    <dbReference type="OMA" id="NITFRTH"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK44"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="1">
        <location>
            <begin position="133"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="529" mass="60061" checksum="3A6646A3913BBE29" modified="2014-10-01" version="1" fragment="single">MQKHRRARALSRFSQFISTGNHSEVVSTKVFIPLFFNLLFGVQEGKGENVRSACMEAIASIAGCMTWKQYYELLMNCFREMTKREKQKVILRLICCILDHFHFSETPAEAKFSDIQTCIQKTMLPKIQELLSDSDNVNVNISLVALKLLKLLPGEIMNLQLPNIVHRISNFLKHRLESVRDEARLALAACLKELGLEHLQFMVKVLRGTLKRGSELHTLGYTLNFILSKFLINPIRGKLDSCLEDLFSVIEIDILGDVSEQKEVDKIASKMKETRKQKSFETLKLVAQNITFRTHAVKLLSLVTAHLQKQLSPKLKSKLENMLNHIADGIQSNASVDQTELFIFVYRLIKDGIDDVNHERKHVYMSEAGKGDCDLVDSQMINSDRLINLEPRYSHLITGFALGLLQNHIKGMKLNRKDEEQLSLCLSPLVRLPLPSLESQSDKIKNSLLFIAQRSANAGSPLVESCLRLLTVLLHNTGVTLSADQLHMLIQFPLFVDIERNPSIVSLSLLKSIVNRKLVVPEIYDVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL87</accession>
    <name>A0A068VL87_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_4306</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00009818001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743390">
        <property type="protein sequence ID" value="CDP21466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL87"/>
    <dbReference type="Gramene" id="CDP21466">
        <property type="protein sequence ID" value="CDP21466"/>
        <property type="gene ID" value="GSCOC_T00009818001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL87"/>
    <dbReference type="OMA" id="EINDECV"/>
    <dbReference type="PhylomeDB" id="A0A068VL87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="184"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="439"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="689"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP21466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118303" checksum="CDC45D33CF409DBA" modified="2014-10-01" version="1">MADAVISATIQVALETALSLASDRIGMLVGFKKDVASMTQSLGFINARLADAEEKQQNQDRVVQEWLKRLEEVAYDAQNVLDELHYESLRHQVESRNRHKLKVCCFFSFSNINLAFRWRMASKVRDVKLKLKEINQQARDFGLDSKSVVPAALPAAPAVGGTRGRQTDSVVAPMVGRADDELNILEMLLSSSEKVVSVLPIIGMGGLGKTTLAKSIYNNHQIDEQFKKKLWVCVSKKVPIEELFKLILGQLKKDKKDEVGDRQNIVQEIGKELGKLRYLLVLDDVWDDDEALWHDFFTTLKGLNPTNGSWCLVTTRLGPVAHSVSRVLMMENEPYALKGLPDDHCWSIVKEKVVGREEEPDELKAIKDRVIKRCDGLPLAASVIGGLLSLKRKEEWQSILENRLLSLSAGGDHVRQILQLSFDNLPSPYIKKCFAYWSIFPKDTEMEGDMLIELWMAEGFLQADVNRQMMMEEIGMNYLRILLQSSLLEEIIDESETSTSYKMHDLVHDLAESMSKSTKVINNGDTYTVDNDNQIRYLTIDSFGGAEDREKLLESLSASLHTLFVFGDLSDDMLMKLKNLYVLFLCTETSEELPVSIGKLIHLRYVNLSKSSISIFPDSLCKLYNLQTLTLSVSQVKDLPKGMCDLISLRHLHLNNSDKEFQMPPEMGRLTCLQTLEFFNVGREKGRRIGELGSLKNLKGKLEIRNLELVKDKEGAEEAKLSEKANLFRLVLEWAPDREGDDYNDEDVLDGLRPHPNLEELVIENFMGDQFPRWLMDLPTTTTLSESATTLSKLARLKFKWCHRCKELLPLQNFTSLKKLLIDKCDGLTNLLGDMLHSCTSLQKLQVIGCDNLISFPLDLQQTPCLLELVLFGCPKLKTSMTPKGFGFLTSLRLLVIGPFSDDGDDHENSSIYNEFDWSGLISSSSSSSSSALRELQLIGLPHMESLPHQIQYLTTLTSLSLRDFGGIKALPDWFENFAALEVLYLIRFKELRHLPSEDAMRSLTKLNRLTVWNCPLLKERCTPESSGPDSQWSKVSHIQDLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMY4</accession>
    <name>A0A068VMY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00012711001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG747771">
        <property type="protein sequence ID" value="CDP21987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMY4"/>
    <dbReference type="STRING" id="49390.A0A068VMY4"/>
    <dbReference type="Gramene" id="CDP21987">
        <property type="protein sequence ID" value="CDP21987"/>
        <property type="gene ID" value="GSCOC_T00012711001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMY4"/>
    <dbReference type="OMA" id="MYCFISA"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000101">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF71">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="18">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="19">
        <location>
            <begin position="168"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP21987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="540" mass="58983" checksum="5DF5C6B178BAC0A4" modified="2014-10-01" version="1" fragment="single">MKRISLGTDQSALLALKAHITSGQQEFLSKNWSSTAAASSVCDWIGVQCGFRHQRATALNISNMGLTGTIPPDLGNLSFLVSLDLRNNSFHGNLPEELSHLHRLRFIRFSNNRFTGAIPMCLCKISQLQSLDLSSNRFSGDIPKEIGNLEKLTYLSLMNNNFTGVIPRELGKLHGLKVLVLGRNNLTGTIPREIGNLQNLQGLNLEWNQIAGSIPKEIGNLTMLTELYFANNSLTGTIPPEMGNLYQLENLQLPYNGLNGSIPPGLFNLSALRNIALSFNRLSGNLPPDLRYRIPKLFALDLYQNNLGGIIPVSITNCSELWLLSIGSNRFTGTIPDSLGDLRLLRYLHLADNYFTSMELSFITSLTKCKNLVYLTLGANPFNGLLPASIGNLSASLKQLSIGSSEIKGTIPSQTGNLTNLVLLDLQSNHLTGGIPTAFKNLQNLQVDLTTNQFSGSLPECFGNMTSLQELELGNNFLVSAIPNSFWKLRDLLELNLSSNSLNASLPLEVGNLKAITSIDVSANQFSGDIPRTTGDLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN61</accession>
    <name>A0A068VN61_COFCA</name>
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        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_2572</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">GSCOC_T00010168001</name>
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        <name type="scientific">Coffea canephora</name>
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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            <end position="115"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="641" mass="71201" checksum="E4F96CD470E50C25" modified="2014-10-01" version="1">MGKAAVTTTRRATIAKAAKTATPPPEPGPEPEPPAQLVVEMKRKKKKGRPSLLDLQKRQQQQQQQQQKTLTPPPAPPPPNHNSTPTRRSTRRNPTNYNSPSSEFFNNDDDDDDDERQQKKVKLVVRLPQSTQQHFHNSASAADSGADDPDDHQASPRKRMINAVDRRSNDVVFDQGEKALKATDTVHGSSLDIGPTTPLPDKKMLVFVLDRLQKKDTYGAFSEPADPNELPDYHEIIEHPMDFWTLRKKLDAGSYSNLEELEADVMLLCSNAMQYNAPDTIYFRQARSIRELAKRDFENLRNEGDNGEPQPKVIRRGRPPSKNLKKPLESSPVDRVGHELSSGATLASAEDKAIGSNGYNLRKGPAFYRFRSNDAFGTSYRSRNGENYSDWLVDWNSEFPASILRADMKYGKKHFSAVDENRRDTYKQFHPSTSSSNESYLWNSFGDMKRLLPVGLHLEPQAYARSLARYAANLGPVAWNVASRKLKTALPDGLAFGPGWVEENDAPQQLLSAEKLKQANGLVHDRDPSRPVTPSSSGLSTAVAHRPSPEMAEAVRRLNCQNELAEQAENRGTSQRGNLLGQASDSHVPSEVGMTARCLQAQHRQPLAVPPDLNVRVQASASPSSSLQIGSPQQPDLALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNE7</accession>
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Ixoroideae</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="non-terminal residue" evidence="2">
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            <position position="1"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="183" mass="20493" checksum="0F958A566F79FD41" modified="2014-10-01" version="1" fragment="single">NPIFQYSGTCEFNLDEVRKGLKKVIAKLELNLDAQVHSINEIKIFVDKKGGFGSANAARAEYQEHDNDGFGDTLFQYITKKNKKGLAESSSRKQKSKTKQTSKHTVPLSSNKSDSSNDDDDNSDNGDGGNNSFKHSGGYNQDSQQTRGMLWVQGQDNYYATQDTDHDYRPGIEAQRQFLNNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLC8</accession>
    <name>A0A068TLC8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014268001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLC8"/>
    <dbReference type="Gramene" id="CDO97046">
        <property type="protein sequence ID" value="CDO97046"/>
        <property type="gene ID" value="GSCOC_T00014268001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="73" mass="8105" checksum="2EAF34024A4D8591" modified="2014-10-01" version="1">MKSLLKTSSKSRAVMCPIPTTGPPLQGEKPGALVKHRRRPVVKKLRCKSSLSFSSVLNVHGWSLYSKKNKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLP8</accession>
    <name>A0A068TLP8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">DNA repair protein REV1</fullName>
            <ecNumber evidence="13">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00014499001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="13"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLP8"/>
    <dbReference type="FunCoup" id="A0A068TLP8">
        <property type="interactions" value="2281"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLP8"/>
    <dbReference type="Gramene" id="CDO97230">
        <property type="protein sequence ID" value="CDO97230"/>
        <property type="gene ID" value="GSCOC_T00014499001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLP8"/>
    <dbReference type="OMA" id="EELHKCF"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000019">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000004">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="410"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDO97230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1128" mass="125110" checksum="0D9A0B2D48E00E37" modified="2014-10-01" version="1">MSLNSSSRSATSNSNSKRSVTSNSNSNPSTSGNNSCRNNDKRNRKRKTDQNQKTLGMAWGANSRSSSRSAFRNSPFPDFGRQFPTYMVMKNQKLHQQFDAEASSSSVSGACSGKPIFDGVSIFVDGYTVPSSQELKGYMLKYGGRFENYFSRHHVTHIICSNLPDSKIKNLRSFSGGLPVIKPTWVLESVAANKLLSWIPYQLDQLASETKKQPKLSAFGFKSGPVLDDLEESISGQAVPQSGIATLRTSCSLEANIFGKAECTEEVEECHSVSDDPFHPNAAESTDQAPTYCMENHCEVELDAAVVGQSDAGYHSHISPCQDPKSDHNDCLEDHIIEESSSSKTIRPSTTGHSTLSDANFVENYFKFSRLHFIGTWRNRYRKRFLSSANGFKDMNPSRNAFATSQKTTIIHVDMDCFFVSVVIRKHPDLKDKPVAVCHSDNSRGTAEISSANYPARNHGVKAGMFIRDAKALCPQLVILPYNFDAYEEVADQFYDILHKHCNKVQAVSCDEAFIDVTDLRVEDPELFARAIRTEIHETTGCTASAGISGSMLMARVATRIAKPDGFCNYEADKLGSVDDYLHELPVKALPGIGHVLEEKLKKKQINTCGQLRLISKESLQKDFGVKTGDMLWNFSRGIDNRLVGVFQESKSIGADVNWGVRFNDLNDMKDFLLKLCKEVSLRLQGCGLKGRTITLKIKKRRSDAGEPVKYMGCGDCENLSRSVTLPMATDDVDVFQRITAQLFGYFHIDARDIRGAGLQASKLESADRNIRGHEKYSIRSWLVSSPARKSSMGKDVSEHMNGAGKGDQLYSDIGPPVQAKGSFSGGEAHVVHRATLPALHELDVGVIESLPPEVLSEINDLYAGELISFISKKKEKNAGNSLWLFIFDSLSLSLCVSRFLHNVLVINICICLAKQYINKMIQGLPETSGSVTALLPETDSLMPSSLSQVDSSVLQQLPEELLADVLVSLPTHRRPDFMSNDVYLDHIRDQTGAIDFLPSNNLWVGNPPRWVDNFRLSSCQLLNRIAVLYNKSSPRGQFSSVLQLIMSEYPLDDGGDDAVNCLCELMKQYIKLKIETDVEEIYTCSCLLRRLTSRSELFLQVYNCIIPHLQAAVGETYGGDLNICFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN79</accession>
    <name>A0A068TN79_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014829001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN79"/>
    <dbReference type="FunCoup" id="A0A068TN79">
        <property type="interactions" value="3327"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN79"/>
    <dbReference type="Gramene" id="CDO97477">
        <property type="protein sequence ID" value="CDO97477"/>
        <property type="gene ID" value="GSCOC_T00014829001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN79"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN79"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000146">
        <property type="entry name" value="protein RAE1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="348" mass="38772" checksum="6E8824F05A0CACF7" modified="2014-10-01" version="1">MATFGAAAASSYNPNRSAEVVQPPSDSVSSLCFSPKANFLVATSWDNQVRCWEVMRSGTNVSTVPKAAMAHDQPVLCSTWKDDGTTVFSGGCDKQAKMWPLLSGGQPVQVAMHDAPIKEIAWVPEMNMLVTGSWDKTLRYWDLRQPNPAHVQQLPERCYALTVRYPLMVVGTADRNLIVYNLQNPQTEFKRITSPLKYQTRCLAAFPDQQGFLVGSIEGRVGVHHLDDAQQQKNFTFKCHREGNEIYSVNSLNFHPVHHTFATAGSDGAFNFWDKDSKQRLKAMSRCSQPIPCSTFNSDGSIFAYSVCYDWSKGAENHNPATAKSYILLHSVQESEIKGKPRISTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP17</accession>
    <name>A0A068TP17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00015076001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP17"/>
    <dbReference type="STRING" id="49390.A0A068TP17"/>
    <dbReference type="Gramene" id="CDO97669">
        <property type="protein sequence ID" value="CDO97669"/>
        <property type="gene ID" value="GSCOC_T00015076001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP17"/>
    <dbReference type="OMA" id="RIFHASM"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="335" mass="36425" checksum="A33DED17A646937E" modified="2014-10-01" version="1">MSGIFRYKTKLRSLAPKITTLSLSSSKFQSSPRKTLSKISEYFPHPQPRPHLNPLGFVSHIQERHKWHGSSDNYDHIKAEVNCPRCSKLMSVLFSNRPLSISRSEPGVYQAVNLCPNCRTAFYFRPFKLEPLQGSFIELGRLKGGKVDMEGNSESGGTGGRGGENGKKIWEKLRNYSGGSSASSNNVKEGSSNSGGDVEEKAVGPAWVEVGSGGGEFEGANLGKELPTPKEISRGLDDFVVGQERAKKVLSVAVYNHYKRIYHASLHGESGAEYRSTDGKIGDFDADDVELEKSNVLMMGPTGSGKTLLAKTLARVVNVPFVIADATTLTQAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ68</accession>
    <name>A0A068TQ68_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014873001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ68"/>
    <dbReference type="Gramene" id="CDO97508">
        <property type="protein sequence ID" value="CDO97508"/>
        <property type="gene ID" value="GSCOC_T00014873001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ68"/>
    <dbReference type="OMA" id="KFRICKE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ68"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35969" checksum="F61E2247776E7188" modified="2014-10-01" version="1">MPLWIQRASKKIALKSITRCFHGTPAQFESHLPKAETIWFIKVHLNPSIAFFVIQHINNHFSNPRLAFEFFQFTRLNLSLVHSVSTFNLLLMSLCQIGFFDLAQLMLDYTITDGLLLDGSVVEFLVSCFANAGKFRICKEVLISQANLSSEKEEVVSSFAHNILLSMLVKRNRVDEAVQFFQDHILILRGFCPDTCSFNIVIRGLCKGGQVDKAFQLFYDMGSFGCSPDMITYNSLINGLCTVGNLDRALCLLRDIQSQVGVAPDVVTYTSIISGLCKSGKMEEAASLLDEMVQCGIRPNLITFNVLIDGFGKSVVIVRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR87</accession>
    <name>A0A068TR87_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022677001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR87"/>
    <dbReference type="FunCoup" id="A0A068TR87">
        <property type="interactions" value="1864"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98542">
        <property type="protein sequence ID" value="CDO98542"/>
        <property type="gene ID" value="GSCOC_T00022677001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR87"/>
    <dbReference type="OMA" id="EKHAKFV"/>
    <dbReference type="OrthoDB" id="47923at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31923">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31923:SF1">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="271" mass="30039" checksum="D0DEF36C057132E7" modified="2014-10-01" version="1">MDFWQRARSFAEEAAKRSQELTNGISSSKLSDVVSEASKRSMEIAAEASKKSKEIAAEALKRADQIKSQLPPAAVALSNLVDTSTQAATPPAVSAADLEKFGVTDELREFVQSITMNTFRDFPLEDDSEVSDIPAVSNVRQDLTEWQEKHANLVLATVKEIKSLRYELCPRVMKERKFWRIYFILVNSHVDPYEKRYMEEKLKTGEKQENVQQEISSAGTTSGAALGGANQKSKNATSEQDLDVFLLGDTGDSDEGPDDGDDGFDDDFDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR99</accession>
    <name>A0A068TR99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pectinesterase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025645001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR99"/>
    <dbReference type="FunCoup" id="A0A068TR99">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98741">
        <property type="protein sequence ID" value="CDO98741"/>
        <property type="gene ID" value="GSCOC_T00025645001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR99"/>
    <dbReference type="OMA" id="KMMKTMM"/>
    <dbReference type="OrthoDB" id="1918674at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15796">
        <property type="entry name" value="CIF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000009">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034087">
        <property type="entry name" value="C/VIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357:SF8">
        <property type="entry name" value="OS01G0111000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357">
        <property type="entry name" value="OS02G0537100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654144" description="Pectinesterase inhibitor domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="5">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO98741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="20435" checksum="3FB98DF7EEF50BA2" modified="2014-10-01" version="1">MKSFAFSCIVLAILPSLSTSYALPPLKKSNHHIFMVREKVNDLIENTCRNTPDYQLCFSTLLSDPRSFDADTYGLGLIIVDALKDKATSAVNAINRLKGSNPEFIRPLIKCSISYNAILKADIPEAIEGLRKGVPKFAEYGMADTAVEVQGCENSFKQSNSPLTDLNKQVYDLSIVAKSIIRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRD3</accession>
    <name>A0A068TRD3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021876001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRD3"/>
    <dbReference type="FunCoup" id="A0A068TRD3">
        <property type="interactions" value="1487"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRD3"/>
    <dbReference type="Gramene" id="CDO97928">
        <property type="protein sequence ID" value="CDO97928"/>
        <property type="gene ID" value="GSCOC_T00021876001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRD3"/>
    <dbReference type="OMA" id="YCENEVY"/>
    <dbReference type="OrthoDB" id="1857192at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000298">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000211">
        <property type="entry name" value="Dual-specific kinase DSK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF14">
        <property type="entry name" value="INACTIVE PROTEIN KINASE SELMODRAFT_444075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="400"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="730" mass="80583" checksum="4D9FFBF3B06D8ED9" modified="2014-10-01" version="1">MSKDLTKGKLDRDSVTEKVVVAVKASKEIPKTALVWALTHVVQPGDCITLLVVVPSQNPGKKLWGFPRFAGDCASGHRRSHAGTTSEQKSDITDSCSQMILQLHDVYDPNKINVKIKIVAGSPFGPVAAEARRTQANWVVLDKHLKHEEKRCMEELQCNIVVMKRSQPKVLRLNLVGSPKKEPEATGASSSKLDQSSGKGEANKNDSLISTRGLLVTPTSSPEMFTATEAGTSSVSSSDPGTSPFFVTETNSDLKKDILLATKQDQDLDESSSDTESENLSTTSSSLRFQPWVADVVNSRCQSSLSEESTERLNNRSQNSTTKALLEKFCKLDEEAAFCSPNYRSNLDFSGNVREAISLSRNGPLGPPPLCSICQHKAPVFGKPPRWFTYGELELATGGFSQANFLAEGGYGSVHRGVLSDGQVVAVKQHKLASSQGDQEFCSEVEVLSCAQHRNVVMLIGFCIEDGRRLLVYEYICNGSLDSHLYGRHHNPLEWSARQKIAVGAARGLRYLHEECRVGCIVHRDMRPNNILLTHDFEPLVGDFGLARWQPDGDTGVETRVIGTFGYLAPEYAQSGQITDKADVYSFGVVLVELVTGRKAVDLNRPKGQQCLTEWARPLLDEYAIDELVDPRLGNQYSEHEVYCMLHAASMCIRRDPHTRPRMSQVLRMLEGDIFMDSSQMSAPGYDVGSRSGRIWAPQFQHQQYSGPIMKETLEGLSGKLSLEERRPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRV1</accession>
    <name>A0A068TRV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Photosystem I reaction center subunit II, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00026052001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PsaD can form complexes with ferredoxin and ferredoxin-oxidoreductase in photosystem I (PS I) reaction center. PSAD may encode the ferredoxin-docking protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Plastid</location>
            <location evidence="1 7">Chloroplast thylakoid membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PsaD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRV1"/>
    <dbReference type="FunCoup" id="A0A068TRV1">
        <property type="interactions" value="938"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRV1"/>
    <dbReference type="Gramene" id="CDO99040">
        <property type="protein sequence ID" value="CDO99040"/>
        <property type="gene ID" value="GSCOC_T00026052001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRV1"/>
    <dbReference type="OMA" id="HNPRRIG"/>
    <dbReference type="OrthoDB" id="44at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRV1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1470.10:FF:000002">
        <property type="entry name" value="Photosystem I reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003685">
        <property type="entry name" value="PsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036579">
        <property type="entry name" value="PsaD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31982:SF5">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31982">
        <property type="entry name" value="PHOTOSYSTEM I REACTION CENTER SUBUNIT II-1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02531">
        <property type="entry name" value="PsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64234">
        <property type="entry name" value="Photosystem I subunit PsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="205" mass="22492" checksum="731C5B53C67DCCF5" modified="2014-10-01" version="1">MAMATQASLFTPTLSSPSDRVTVPWKQSSLVAFASPKPIKTNMATRTIRAMAEEASTAAAPAGFTPPQLDPNTPSPIFAGSTGGLLRKAQVEEFYVITWDSPKEQIFEMPTGGAAIMRQGPNLLKLARKEQCLALGTRLRSKYKISYQFYRVFPNGEVQYLHPKDGVYPEKVNPGRQGVGLNLRSIGKNISPIEVKFTGKQVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT03</accession>
    <name>A0A068TT03_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00026107001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TT03"/>
    <dbReference type="FunCoup" id="A0A068TT03">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TT03"/>
    <dbReference type="Gramene" id="CDO99084">
        <property type="protein sequence ID" value="CDO99084"/>
        <property type="gene ID" value="GSCOC_T00026107001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TT03"/>
    <dbReference type="OMA" id="QISPIFI"/>
    <dbReference type="OrthoDB" id="1914452at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TT03"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="10">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO99084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="18201" checksum="80D136373B567FDB" modified="2014-10-01" version="1">MLTSFTPCLNFITNSSTNGNSPTADCCNVIKAFMANGTGCLCLVATGGVPLNLPINRTLVLSLPRTCNQPGVPLQCKASVAPIPAPGPLAGGPAVSPAANPPTGTMSPAAAPPTGSVVPQAGSPTLAPEAETNPALTPPSSTTNSGSPAGNSGNRQSLTPSAASTLSFSPLLLLAVIGAIALRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTD7</accession>
    <name>A0A068TTD7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026230001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTD7"/>
    <dbReference type="Gramene" id="CDO99179">
        <property type="protein sequence ID" value="CDO99179"/>
        <property type="gene ID" value="GSCOC_T00026230001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTD7"/>
    <dbReference type="OMA" id="PELMGTN"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTD7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000864">
        <property type="entry name" value="Prot_inh_pot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036354">
        <property type="entry name" value="Prot_inh_pot1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091:SF83">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, POTATO INHIBITOR I-TYPE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00280">
        <property type="entry name" value="potato_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54654">
        <property type="entry name" value="CI-2 family of serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00285">
        <property type="entry name" value="POTATO_INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7760" checksum="FF24F1DFC90A8F92" modified="2014-10-01" version="1">MSECPAGKNSWPELVGEDGDKAAAKIEQENQRVKKAIVVDESAIVTTDFRCARVWVFVNKEGKVSVVPKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUY1</accession>
    <name>A0A068TUY1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029838001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUY1"/>
    <dbReference type="FunCoup" id="A0A068TUY1">
        <property type="interactions" value="1274"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUY1"/>
    <dbReference type="Gramene" id="CDP00061">
        <property type="protein sequence ID" value="CDP00061"/>
        <property type="gene ID" value="GSCOC_T00029838001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUY1"/>
    <dbReference type="OMA" id="MAVQVQE"/>
    <dbReference type="OrthoDB" id="1905883at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34958:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34958">
        <property type="entry name" value="CONDITIONAL LOSS-OF-GROWTH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1200" mass="133434" checksum="D956614D3E02AF58" modified="2014-10-01" version="1">MTTSFNSPSRSPASSRIQLGGGGSASRLRSSSLKKPPEPLRRAVADCLSSSASSNHGSFSAAASEALRTLRDYLAANSTTDLAYGVLLEHTLAERERSPAVVARCVSLLKRYLLRYKPSEETLQHIDRFCISIIAECNLNPNHKLAAHSHSLNLQSAAPTTSTNVSPLPVSSFASGALVKSLSYVRSLVAQYIPRRSFQPAAFAGAPTASRQSLPTLSSLLSKSFNSQLSPVNSKEASEKKEASALSVSDLAIPEEVDVSEDYEYIALDIFKWRWCRDQQSSLLSPKSDHVLKPQDVSTHNFLEVGAAALLVGDLEAKMQGKPWGTFGTADMPYLDQLLQPSLLTTVTNSAAARAHLKAITALKRSKPGPQQIWEDSPISMFRPRAKPLFQYRHYSEQQPLRLNAAEVCEVIAAVCTETRSPNANFMTVSSKLSNNSGKPSMDVAVSVLVKLVIDMYVLDSETAGPLTLFMLEEMLNSPRLVSKTRAFDLILNLGVHAHLLEPPLQDEDSPVDEEYSQEQILDNEMPPSSEATRKLDYFKKMGNCSAVDKFECWILGILSEVLLHLVQVEEKEESIWASALSCLLYFVCDRGKIRRSRLKALDIRVIKVLLTISRLNCWAEVVRSKLICMLTNMFYEVPDGSINSASATPMFFTEQIDLIGGIEFIFVELVLSNSRDARRNLYLVLFDYVLHQINEKCIATGESEYNDEEVQPIANLLMLADAPEALHISVKLGVDGIIELLRRSVSAALSRYPNSDRLIVLLEKIVEKFDALISSFTHVDKEFAHMIKTAKSCKFLESIERYRRNSLSMKAKLSWATLHSLLHSERNLYRHHGYLWLGDLLIAEISEGGDTSIWSRIKNLEQKIALAGVNDYSAALDVPLHIWLFCGLLRSKNSFIRWGFLYILERLLMRSKFLLDESEVHHAINVEASGYINDKSRLEKANAVIDIMSSALSLMAQINETDHMNILKMCDILFSQLCLKVLPTSAIPLGDVMLGNRDSSVDWNKKADSEHFTRNESHSWDEFCDTTSTFNPSKDPLVGETASMAALLLHGQAIVPMQLVARVPAALFYWPLIQLAASATDNIALGVSVGSKGRGNVPGATSDIRATLLLLLIGKCTADPAAFKEFGGEQFFRVLLDDTDSRVAYYSSTFLLKRMMTEEPENYQRMLHSLVSRAQQSNNEKLLENPYLQMRGLLQLSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV33</accession>
    <name>A0A068TV33_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029626001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV33"/>
    <dbReference type="STRING" id="49390.A0A068TV33"/>
    <dbReference type="Gramene" id="CDO99912">
        <property type="protein sequence ID" value="CDO99912"/>
        <property type="gene ID" value="GSCOC_T00029626001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV33"/>
    <dbReference type="OMA" id="CAQGHGR"/>
    <dbReference type="OrthoDB" id="1890923at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14527">
        <property type="entry name" value="DSP_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47216">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47216:SF4">
        <property type="entry name" value="OS01G0859400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="156"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="258" mass="28687" checksum="DD5A13E22C92EEB6" modified="2014-10-01" version="1">MGVGISFLIGLKAATLFSLFTFMNNLGFKWFAIPFLYASLISFLVSIASHPSINLPMLLGKGSDGVFPIWSLIIFSPYLYFVRAFSALRRLRSGEAPYSEICEGVYVGGWPFSPDKLPPGNPAVIDCTCELPRKTELSGHAYLCIPTWDTRSPQPAEIESAVKWACRKRAQNSPIFIHCAYGHGRSVAVACALLVALGVAEDWKNAEKLIKERRPYIRMNALHRKALEEWSRFRLSSPKRNDETGLGSVILSSPSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWP8</accession>
    <name>A0A068TWP8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032442001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWP8"/>
    <dbReference type="FunCoup" id="A0A068TWP8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWP8"/>
    <dbReference type="Gramene" id="CDP00487">
        <property type="protein sequence ID" value="CDP00487"/>
        <property type="gene ID" value="GSCOC_T00032442001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWP8"/>
    <dbReference type="OMA" id="RCNWVTK"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31116:SF29">
        <property type="entry name" value="DNA GLYCOSYLASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31116">
        <property type="entry name" value="OS04G0501200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="317" mass="36247" checksum="189E72AE156AE8FC" modified="2014-10-01" version="1">MSKQNPKRYSLEKINKNISSSKENEKQRSAASFLSKHMKKVYPIGLYKTCSSLSLSSLSLSLSQNSNDSSLADSSSQLDQKIALALRLIESPKRREVPAAKTLQKPTTEAACKEPGEEGFRRCNWITKNSDNIYVQFHDECWGVPVYDDHQLFELLALSGMLMDFNWTEILKRKELFREVFAGFDANNVAKMGEKEITDIVSNKALMLAECRVRCIVDNANCILKIVKEFGSFSSYMWNYVSYKPIINRYKHPRNVPLRSPKAEAISKDLLKRGFRFVGPVIVHSFMQAAGLTIDHLVDCFRYSECVNLAERPWRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXA6</accession>
    <name>A0A068TXA6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032544001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXA6"/>
    <dbReference type="FunCoup" id="A0A068TXA6">
        <property type="interactions" value="1036"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXA6"/>
    <dbReference type="Gramene" id="CDP00564">
        <property type="protein sequence ID" value="CDP00564"/>
        <property type="gene ID" value="GSCOC_T00032544001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXA6"/>
    <dbReference type="OMA" id="SWYVRRF"/>
    <dbReference type="OrthoDB" id="1909609at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXA6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053262">
        <property type="entry name" value="ArsA_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43868">
        <property type="entry name" value="OS02G0711200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43868:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA HSP20-like" evidence="3">
        <location>
            <begin position="395"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49778" checksum="9440AD4516B503A2" modified="2014-10-01" version="1">MALSTAPILSPLSSALSLLSSNFIIPDSSIFHGIDTSIRTVKRNSRNRAVTIAQNDKDKPTKLVTFLGKGGSGKTTSAIFAAKHYAMEGLKTCLVIQSQDPTAEHLLNCKIGTSPIKCNNHLSAVRLQTTKMLIEPLNRMKEADARLNLTQGTLEGVVGEELGVLPGMDSIFSMLALGRILGFLRNTSQGRGQQDEFDIVVLDGISTEEVIRMIGATSKARLYLKYLRKLAEKTDLGRLAGPSLLRLLDEALSFSSGGANANVQLSSEVWDHLEKTLERGSAFFQKLQKFSCYIVMNQDSQLSVMSALRYWGCAIQAGVQVSGAFAFASPNAELAATAKDFSPLPFASIPHLSMSAHPNWNEVLVNAQSQDARQLLNLTSKQTSIFPPVTFDPGNKSITLFMPGFDKSEIKLFQFRGGSELLVEAGDQRRVIQLPSQIQGKVGGAKFIDRNLLITMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXY7</accession>
    <name>A0A068TXY7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034717001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXY7"/>
    <dbReference type="FunCoup" id="A0A068TXY7">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXY7"/>
    <dbReference type="Gramene" id="CDP01170">
        <property type="protein sequence ID" value="CDP01170"/>
        <property type="gene ID" value="GSCOC_T00034717001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXY7"/>
    <dbReference type="OMA" id="DHRVNPM"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXY7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="282" mass="32747" checksum="448917A061C49BE8" modified="2014-10-01" version="1">MSNLRAICRPYAVFSCCRSVVRVRVSIGSPFNLGSPSLSPKSSVSVFLSPPPLLGLDSAIKMEPWATRWRLNQQRRMGVKASSNWTDSKSPYDTLELERDADEEQIKVAYRRLAKFYHPDVYDGKGTLEEGETAEARFIKIQAAYELLIDQEKRRQYDNDNRVNPMKASQAWMEWIMKKRKAFDQRGDMAIAAWAEQQQRELNLRARRLARSKTDPEEERKILAKEKKASLENFNNTLRRHTLVLKKRDLMRKKAEEEKKKAISRLLAAEGLELEKDENEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYU4</accession>
    <name>A0A068TYU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034728001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYU4"/>
    <dbReference type="Gramene" id="CDP01177">
        <property type="protein sequence ID" value="CDP01177"/>
        <property type="gene ID" value="GSCOC_T00034728001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="92" mass="10358" checksum="542C83A470513015" modified="2014-10-01" version="1">MPRSQFPLLAWVCSVFSSSSVKEDPLKHTPTRQQRIGTVFTFVKLTFITTLIFSLNFSLFSISSALFSSYPFSDLLLFVATFVLLASEPLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ20</accession>
    <name>A0A068TZ20_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036640001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ20"/>
    <dbReference type="Gramene" id="CDP01550">
        <property type="protein sequence ID" value="CDP01550"/>
        <property type="gene ID" value="GSCOC_T00036640001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ20"/>
    <dbReference type="OMA" id="CCRTANE"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="125" mass="12212" checksum="2984DF934C80CF05" modified="2014-10-01" version="1">MNKDKAKEPEQYGGRCRYGCCGRRGPYGCSKCCRTANEAEATQVNADINGNEGGGHGGGGGYGGGGGGHGGGGGGSGGGHGGGGGHGGGGGYGGHCRYGCCGGYGKYCRCCYNPEEAQAFVQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ65</accession>
    <name>A0A068TZ65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034958001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ65"/>
    <dbReference type="STRING" id="49390.A0A068TZ65"/>
    <dbReference type="Gramene" id="CDP01352">
        <property type="protein sequence ID" value="CDP01352"/>
        <property type="gene ID" value="GSCOC_T00034958001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ65"/>
    <dbReference type="OMA" id="YTQDHIC"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ65"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="1">
        <location>
            <begin position="161"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="362" mass="41176" checksum="3C350AE34F1BFC85" modified="2014-10-01" version="1">MTNPAIGFQCNNLLPVIWDDLICHFIFPLYNVFLVQLTNYMQLFAFVLVKSKCISLAIKFICPWQFLIEVDIIFNVNNTATFLSDSLDTTKRKIGIEDGEDLPKRKVTKKKTRLITPTSEQLASLNLNGGRNSIVFTFSTPMLGKQQVDARIYLWKWDTRVVISDVDGTITRSDLLGQFMPLVGVDWSQTGVAHLFSAIKENGYQLLFLSARAISQAYNTRQFLLNLKQDGKVLPEGPVVISPDGLFPSLYREVVRRAPHEFKIACLEEIKALFPPDRNPFYAGFGNRDTDEISYLKVGIPKGKIFIINPKGEIVVNRRVDTKSYTSLHALVHDMFPPMSSSEQEDYNSWNYWKLPPPAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0Y8</accession>
    <name>A0A068U0Y8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DnaJ homolog subfamily C member 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00037012001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0Y8"/>
    <dbReference type="FunCoup" id="A0A068U0Y8">
        <property type="interactions" value="2831"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0Y8"/>
    <dbReference type="Gramene" id="CDP01839">
        <property type="protein sequence ID" value="CDP01839"/>
        <property type="gene ID" value="GSCOC_T00037012001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0Y8"/>
    <dbReference type="OMA" id="SFWYDFD"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0Y8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000416">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="99"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="455"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="5">
        <location>
            <begin position="589"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="594"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="73979" checksum="F15471F2AEA47CD6" modified="2014-10-01" version="1">MAATSSMRLISYAEEIIDGQAVYVSSNSSPVKAFNFEPAGHAFHSAALRLSGVLEDDDNDNDDEKSDTTSDKDQSYTQTSESYSTKGKKKSGSGEKQQDHYALLGLGHLRYLATEDQIRRSYREAALRHHPDKQAALLLAEETEAAKQAKKDEIENHFKAIQEAYEVLIDPTRRRIYDSTDEFDDEIPTDCAPQDFFKVFGPAFLRNGRWSVSQPIPSLGDETTPLKEVDNFYNFWYSFKSWREFPHADEFDLEQAESRDHRRWMERQNAKLSEKARKEESARIRALVDNAYKRDPRILRRKEEEKAEKQRKKEAKILAKKLQEEEAARIAEEERLRKEEEDKRAAEAALHQKKAREKEKKLLRKERTRLRTLLAPLLSCDLLEEDVEKLCMSLDMEHLRNLCNKIEENEDVQRVKIVKDALGHGHNLKDEKEDVKGALRNGAALEANGQFPLGTKEKIEKPWSKEEIELLRKGMQKYPKGTSRRWEVISEYIGTGRSVEEILKATKTVLLQKPDSAKAFDSFLEKRKPAPSIASPLTTREEVGGVSNGNASQKHAGKPDNLQDSSSQTANQQNSDVAVSAENGVSSTGDQDVWSAVQERALVQALKTFPKETNQRWERVAAAVPGKTVVQCKKKFALLKESFRNKKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1F5</accession>
    <name>A0A068U1F5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039702001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="885"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1F5"/>
    <dbReference type="Gramene" id="CDP02341">
        <property type="protein sequence ID" value="CDP02341"/>
        <property type="gene ID" value="GSCOC_T00039702001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1F5"/>
    <dbReference type="OMA" id="GRGITCE"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1F5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="167"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="475" mass="51201" checksum="B1D5A9A91E713F37" modified="2014-10-01" version="1">MDIDEIFGESRPVSLPTKSAVYVWGYNQSGQTGRKGRERNMRIPRQLPPDLFGCPAGGNSRWLDIACGREHTAAVASDGSLFTWGANDFGQLGDGTETGRKHPQKVRQLQSEFVVSVSCGAHCTAAIAEPRQNDGTMSVRRLWVWGQNQGSNYPRLYWGDFAPNTIIRQVSCGAVHVVALSEEGLLQAWGYNEYGQLGRGVTCEGLQGARVIKGYAKFLDDAPELVKIVQVSCGEYHTAAISEDGEVYTWGLGSMGQLGHSSLQSGDKELLPRRVVALDGIFIKDIACGGVHTCALTANGALYAWGGGQAGQLGLGPQTEFFSCVPNESEVMLRNLPVLVIPTGVQLVACGYSHTLVSTRDGRIHGWGYNSYGQAANEKSTYAWFPSPVDWCVGEVRKLAAGGGHSAVLTDACSLKELCEFRLADCMTLSNASKIEDVASRTGSDALARLCERLRAHRCGAGECNYDNDDDEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2J9</accession>
    <name>A0A068U2J9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00040258001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2J9"/>
    <dbReference type="FunCoup" id="A0A068U2J9">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2J9"/>
    <dbReference type="Gramene" id="CDP02765">
        <property type="protein sequence ID" value="CDP02765"/>
        <property type="gene ID" value="GSCOC_T00040258001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2J9"/>
    <dbReference type="OMA" id="WGLDIKE"/>
    <dbReference type="OrthoDB" id="639110at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2J9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037690">
        <property type="entry name" value="FAM204A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14386">
        <property type="entry name" value="PROTEIN FAM204A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14386:SF2">
        <property type="entry name" value="PROTEIN FAM204A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="138" mass="15119" checksum="E5A23834DD5C1071" modified="2014-10-01" version="1">MEEGERREAAIASAASLQPNFTPKKSNITPSQLSKFHELHKRRLKIKAKSKTKTKIKGPEGNGKSHENGSNGKERIGKASGATTTVEGSSVPFPKGSTDENSSVQESVAAHPVSTPKRQKKLHWGLDTKERWEMKANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3G4</accession>
    <name>A0A068U3G4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00041527001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3G4"/>
    <dbReference type="FunCoup" id="A0A068U3G4">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3G4"/>
    <dbReference type="Gramene" id="CDP03051">
        <property type="protein sequence ID" value="CDP03051"/>
        <property type="gene ID" value="GSCOC_T00041527001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3G4"/>
    <dbReference type="OMA" id="NGKDSCE"/>
    <dbReference type="OrthoDB" id="1918918at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3G4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF215">
        <property type="entry name" value="OS02G0781300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP03051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="218" mass="24120" checksum="5187382C8621C6A3" modified="2014-10-01" version="1">MVKPEPQKRSSSPPSTAATLERFKVAGDHSSSSIKYTGVRKRKWGKYVSEIRLPNSRERIWLGSYDTAEKAARAFDAALFCLRGKSAKFNFPDNPPEIVNGRSMTPAEIQVAAAQFANSEHRLIGEPARIDNLVSDNSSSSISSLELQAESPCPSVSDGVVQLESELPEIPLDNAFLDMFGIFPGFDDFFVPPMPTVDLDGEENYEGYFSQDSTLWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5M7</accession>
    <name>A0A068U5M7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00015283001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5M7"/>
    <dbReference type="FunCoup" id="A0A068U5M7">
        <property type="interactions" value="2059"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5M7"/>
    <dbReference type="Gramene" id="CDP03484">
        <property type="protein sequence ID" value="CDP03484"/>
        <property type="gene ID" value="GSCOC_T00015283001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5M7"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5M7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF35">
        <property type="entry name" value="ZINC TRANSPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP03484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="343" mass="36786" checksum="07D3E2502C8AF60E" modified="2014-10-01" version="1">MANQNFQILVFSTLFPSTNGNTDGNRSSALKYKLGAIAATLFASSIGICLPIWGKKIPSLNPKSNFFFIIKAFTAGIILATGFIHILPDAFDSLTSPCIPINPWGNFPFTGFVAMVAAICTLMVDVYANSYYKKKYGNENFQATVGAGDRNNGESNLSGVLPLHTHAIHGHGHASMEGDTISTELRYRVISQVLEFGIIMHTRFIAIALGASGSLKTIRPLLVAFTFYLFFEGIGLGGCITQGKFNVRAIAIMSVFFSLTTPVGIAIGIGIANVYKHNSPIAIIVEGIFDSASAGVLIYMALVDLLSADLMNPKMQSNSKLLLGANVSFLFGASCMCLLAKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5S1</accession>
    <name>A0A068U5S1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00015923001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5S1"/>
    <dbReference type="FunCoup" id="A0A068U5S1">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5S1"/>
    <dbReference type="Gramene" id="CDP03524">
        <property type="protein sequence ID" value="CDP03524"/>
        <property type="gene ID" value="GSCOC_T00015923001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5S1"/>
    <dbReference type="OMA" id="RNSEAIP"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5S1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000023">
        <property type="entry name" value="Metal tolerance protein C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000008">
        <property type="entry name" value="Metal tolerance protein C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="96"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="322"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="523" mass="56598" checksum="5C36F38526EB7667" modified="2014-10-01" version="1">MRIRSLKNLATPIIIHKKTLWLLGIGGRGRTTNFNPVIGALTLSSSPYQNDHSLAYTENPNFKISKRWHIGHSDHHRDHEDDLLSGKEGERIFRLGLASDVGLAAGKALTGYLSGSTAIIADAAHSVSDVVLSGVALLSFKAARVPKDKEHPYGHGKFETLGALGISAALLATAGGIAWHAVDVLLGFWCAAPEVINQSLAHEHMHGHGQGGHHHGIDMAHPVLALNMTIVSIAVKEGLYWITKRAGERANSRLMKANAWHHRADAVSSVVALIGVGGSILGVRFLDPLAGLVVSGMILKAGLETGYESVLELVDAAIPSQLMEPYRNAILQVEGVKGCNHLRGRRAGSFLYLDVNVEVDPFSSVSAAHDVGENVRRKIQQSHPEIAEVFIHIEPSSSGIPPVHSATEEDGKSNENPSVSLECSDVEDIVSNILSSKFAEKLTVQRITRHMLQGRILLQIEVTMPPDMLIRDAVKVAEEAEKVIFEAVPNNVSISMQLRLAHATPNLHYEWKESDNGSRVTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6S9</accession>
    <name>A0A068U6S9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">signal peptidase I</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00041867001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6S9"/>
    <dbReference type="FunCoup" id="A0A068U6S9">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6S9"/>
    <dbReference type="Gramene" id="CDP03323">
        <property type="protein sequence ID" value="CDP03323"/>
        <property type="gene ID" value="GSCOC_T00041867001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6S9"/>
    <dbReference type="OMA" id="NDRMIVN"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6S9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000012">
        <property type="entry name" value="Peptidase/ serine-type peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390:SF1">
        <property type="entry name" value="CHLOROPLAST PROCESSING PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="SIGNAL PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase S26" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="165" mass="18615" checksum="4EF0D30DFA454D6B" modified="2014-10-01" version="1">MYPTFDVGDRVVAEKVSYYFRRPCPNDIVIFKSPPVLQEVGYTDDDVFIKRVVAKEGDTVEVHEGKLVVNGVVRGEDFILEGPKYEMTAIRVPENSVFVMGDNRNNSYDSHVWGPLPLKNIIGRSIFRYWPLTRIGSTVLPESCVFDKQETSLAANNTPSESPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6V7</accession>
    <name>A0A068U6V7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041905001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6V7"/>
    <dbReference type="Gramene" id="CDP03353">
        <property type="protein sequence ID" value="CDP03353"/>
        <property type="gene ID" value="GSCOC_T00041905001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6V7"/>
    <dbReference type="OMA" id="KAGAGLX"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053329">
        <property type="entry name" value="Merozoite_Surface_Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654623" description="Glycine-rich cell wall structural protein-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="39856" checksum="47C9CA4C4D61D915" modified="2014-10-01" version="1">MVGKRLIVLVLVLFLTLAAAICAESSWESKNINDGDVEVGASVKKNLPEWFVGGGSSAAASWSGNEGLGSGGISKGYSLGHSFNFGGSGGGIGGGVGEGKGEGIGGGIGKGGGVGGGIGKGGGIGGGSGGGIGGSSGGEIGGGVSKGGGIGGGSGDGIGGGVGKGGGIGGGIGKGGGIGGGSGGGVGGGIGKSGGIGGGSSGEIGGGIGKGGGIGGGSGGGIGGSSGGEIGGGVSKGGGIGGGSGDGIGGGVGKGGGIGGGIGKGGGIGGGSGGGVGGGIGGIGGGVGKGGGIGGGIGKGGSTGGGSGGGIGGGTGKGGGLGGAIGGGSSGGIGGGGAGGGTSGGIGGGAGAGSGGSAGGIGGGGAGGGTGGVIGGGAGAGSGGSAGGIGGGGAVGGIGGGGASGGVGAGSGGSAGVIGGGAGVGFGDGIGKGIGVGGGSGGGVGGGGFGGSGRFGGGAGGEFGGVGGGGSFRGGSSVGVGSGSGIGGGFGGVGGAGGGIGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8U6</accession>
    <name>A0A068U8U6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00018619001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8U6"/>
    <dbReference type="Gramene" id="CDP04614">
        <property type="protein sequence ID" value="CDP04614"/>
        <property type="gene ID" value="GSCOC_T00018619001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8U6"/>
    <dbReference type="OMA" id="HCRNSRA"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8U6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1427">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP04614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="495" mass="55848" checksum="0D23BE8B9F7F489B" modified="2014-10-01" version="1">MDHQDELVPHVLIFPLPIQSPVNSMLKLAELLCLAGHRVTFLNTKHNHNRLLRCTNIQSRLDQYQGRFLLEKVDDGLPDEDPRTAEQFTEILDSLQSVAEPFLREVLCGERFSCNSSKRPPITCIIADGSYYYVLDVAEEMGIPLIFFETISPCCLWVYMCVPKLIEAGELPFKGNDLDAEVRSIPGMEGLLRCRDLPDFCRRDCTADRNAQLVMAEIRNIPRAAGLILNTFEDLEGPFLSHIHSQARNLYAIGPLQLHLKTKLAAQSRELPTAVSNSFWVEDTSCLCWLDSQPLKSVIYISFGSLKNITKDEFLEFWHGIMNSGQRFLWVIRPGSIKGQKLEQHDDFLKELNRGTKGKGLILSWVPQEEVIGHSAIGGFLSHSGWNSTLESIIAGVPMICWPCYVDQQVTSRFVSETWTLGLDMKDTCSRSIIEKMVRDIIERRCDFDQSADKFSKLARQSVAAGGSSHIDLDRLIGDIKKLSLEGDTNASFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U904</accession>
    <name>A0A068U904_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017386001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U904"/>
    <dbReference type="FunCoup" id="A0A068U904">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04093">
        <property type="protein sequence ID" value="CDP04093"/>
        <property type="gene ID" value="GSCOC_T00017386001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U904"/>
    <dbReference type="OrthoDB" id="671858at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U904"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34570:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34570">
        <property type="entry name" value="OS03G0593100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15732" checksum="3874614FDA846B15" modified="2014-10-01" version="1">MGRPNRQNRDTAIVGPSIVLLQERFKKLGRIKERREQRRQTLKMVFSEPQRILQSNCRSYNSFTDHELNLYLPSRPAFDEDPLSLGFTLSNEHAEYGALKKAQPSFSALWSYDERVVNTPQMYDKNSDVDTSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9H9</accession>
    <name>A0A068U9H9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020113001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9H9"/>
    <dbReference type="FunCoup" id="A0A068U9H9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05161">
        <property type="protein sequence ID" value="CDP05161"/>
        <property type="gene ID" value="GSCOC_T00020113001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9H9"/>
    <dbReference type="OMA" id="RRCAWRC"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9H9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="505" mass="55082" checksum="0A6F8DFBDE538F65" modified="2014-10-01" version="1">MERAPLLSGSYYDGGEELVGPDGEYRQARGLKEWWYVFRIETVKLWALGLPIALNIICQYGMNAATTMYVGHLGDVELSAISISLSVISTFSFGFLLGMGSALETLCGQAFGARQVHMLGVYMQRSMIILFVTSVILLPLYIFATPLLKLLGQQEQIADPAGKYSILIIPQLFSLVVTFPTQKFLQAQSNVAITAYIGLVALLLHVLLLWLFIYVLGWGITGAAVAFDISNWAIAIAQFFYVIGWCKDGWKGWSISAFREIWSFVRLSLASAVMLCLEIWYMMSINILTGHLHNAVLAVGSLSICMSLNGIEAMIFIGVNAAISVRVSNELGLGHPRAAKYSVYVTVSQSLLIGIISMVVVLLARNHFAIIFTNSTDMQKAVANLAGLLSITMVLNSVQPVISGVAVGGGWQALVAYINLGCYYVFGLPLGFVLGYVANLGVKGIWGGMIAGIGLQTLLLLVVLYKTNWNDEVDQTSKRMREWGGQGVDSEKLQNNRPPFGNGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9T1</accession>
    <name>A0A068U9T1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020187001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9T1"/>
    <dbReference type="FunCoup" id="A0A068U9T1">
        <property type="interactions" value="2254"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9T1"/>
    <dbReference type="Gramene" id="CDP05221">
        <property type="protein sequence ID" value="CDP05221"/>
        <property type="gene ID" value="GSCOC_T00020187001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9T1"/>
    <dbReference type="OMA" id="KEECSEW"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9T1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47475">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47475:SF2">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16941" checksum="062BEB21EE98FD51" modified="2014-10-01" version="1">MQIKVKCSCGQGNCPEWAILELQGVVEAQPSFQDRLRNLHIGLLCRASSQESYTFTVGYHELTGTKVPLKKPILVLKKTRVSDGDAVEGEGEEEKDSGGDIASPSNSRVQLAVIGIIRHKILFKTRPKALISGPQTVAMGKISTPSSLAPNCGYTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9Y2</accession>
    <name>A0A068U9Y2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Subtilisin-like protease SBT1.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00020263001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9Y2"/>
    <dbReference type="FunCoup" id="A0A068U9Y2">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9Y2"/>
    <dbReference type="MEROPS" id="S08.A25"/>
    <dbReference type="Gramene" id="CDP05276">
        <property type="protein sequence ID" value="CDP05276"/>
        <property type="gene ID" value="GSCOC_T00020263001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9Y2"/>
    <dbReference type="OMA" id="HSNRTCK"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9Y2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000005">
        <property type="entry name" value="subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000003">
        <property type="entry name" value="Subtilisin-like protease SBT1.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654689" description="Subtilisin-like protease SBT1.3" evidence="11">
        <location>
            <begin position="21"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="14">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="145"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="385"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="15">
        <location>
            <begin position="674"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP05276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="83880" checksum="9EDF5CF55F497590" modified="2014-10-01" version="1">MVALLGKRLLLFVSSYLAFGFLTCTSNKTSSTTTYILQIDKWAKPALFVDHVQWYSSIVKSVTSKPSKVDDSGDEDRIIYTYHTAFHGIAARLNQEEVERLREKHGVMAVFPETVYQLHTTRSPLFLGLENRYGTSVWSDRLSQSDVIVGVLDTGIWPESPSFNDTEMGPVPGHWKGNCEIGRAFGRHHCNRKIIGARVFYRGYEAASGKINERDEYKSPRDQDGHGTHTAATVAGSAVHGANLFGYAYGTAQGMAPGARIVPYKVCWTGGCFSSDILSAVDQAVADGVNVLSISLGGGVASYYRDSLAVAAFGAMEKGVFISCSAGNGGPDPVSLTNVSPWITTVGASTMDRDFPAIVKLGTGEILTGTSLYRGRRTLSTQKQYPIIYPGSNSSSPTPSSLCLEGTLDSHAVAGKIVICDRGISPRVQKGQVVKDAGGVGMILSNTAVNGEELVADSHLLPAVAVGETTGKLIKHYVSRDRKASATLLFLGTKVGIKPSPVVAAFSSRGPNFLSLEILKPDVVAPGVNILAAWTGVTGPSSLPTDPRRTWFNILSGTSMSCPHVSGIAALLKARHPDWSPAAIKSALMTTAYVHDNTFHPLKDASTGVPSTPYDHGAGHINPSKALDPGLIYDIGAQDYFEFLCAQGLTPSQLTAFAKFSNRKCLQHFANPGDLNYPAISPVFPENTKVSVLTLRRTVTNVGPPNSNYHVAVSPFRGALVEVDPRTLNFTRLHQKLSYKVTFKTKSRQTAPEFGHLTWKNTEHKVRSPIVITWLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA22</accession>
    <name>A0A068UA22_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIN4 pathogenic type III effector avirulence factor Avr cleavage site domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017865001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA22"/>
    <dbReference type="STRING" id="49390.A0A068UA22"/>
    <dbReference type="Gramene" id="CDP04463">
        <property type="protein sequence ID" value="CDP04463"/>
        <property type="gene ID" value="GSCOC_T00017865001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA22"/>
    <dbReference type="OMA" id="LSKYCCC"/>
    <dbReference type="OrthoDB" id="765662at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040387">
        <property type="entry name" value="RIN4/NOI4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159:SF49">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05627">
        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="247" mass="27889" checksum="3A11435FB0E57640" modified="2014-10-01" version="1">MTWLQQRSHVPKFGNWEGENVPYTAYFDNARKDKISGTRMNPNDPEENPEAFVFSGLINGGEASEFSPTPLQRNLVRPISSEKYRQKQRYGHWRNTSDEPKSVGQKSPGSESITDKNNYDNPHQQKRSERKKSMMTENSNSFIPLSPARRARGGSDTSDDLSYNSASVPKFGAWDERDPRSGEGFTVIFNKVKEEKRIAASKFAPAQQPQSSNNAESHKRDAKSKVCNLFLQGNARNLDPARAFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC49</accession>
    <name>A0A068UC49_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021028001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC49"/>
    <dbReference type="FunCoup" id="A0A068UC49">
        <property type="interactions" value="1891"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC49"/>
    <dbReference type="Gramene" id="CDP05754">
        <property type="protein sequence ID" value="CDP05754"/>
        <property type="gene ID" value="GSCOC_T00021028001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC49"/>
    <dbReference type="OMA" id="MEYPRTS"/>
    <dbReference type="OrthoDB" id="1927957at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC49"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043424">
        <property type="entry name" value="BLT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071:SF2">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PAN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="680" mass="76747" checksum="59050B8280BEFC10" modified="2014-10-01" version="1">MKITAGKKELQQGPSSTPFNPFQSSDLLEKPSKSSKPHRRKSRGSGNGVRLRKDSGGKRSSRPETPLLRWKFDEVGVEDENELCKQEKSPPEAGRNNGRKVRAVVSARKLAAGIWRMQLPEVSTGGGGKLGFQSGDNYVGVPFHGYHNCKVHDCTTKDLVRSPQSVTGPRNGFSSKAESSFQLSNSAMEGATKWDPVGWKTSNEVKQIFGQQKQFDQEARASAAISALETQLEQARSQIHELEMERRTSKKKLEHFLKKLSEEKAAWRSREHEKVRVIIDDIKADLSRERKNRQRLEIVNSKLVNELAETKLSAKCYMQDYEKERKARELIEEVCDELAKEIGEDRAEVEALKREALKLREEVDEERKMLQMAEVWREERVQMKLIDAKVALEERYSDMNRLIAELESFLSSRGAIRDSEEIRMAELLRQAATSVNVKDVSEFTYEPPNLDDIFSVFEDVNYGEPNERQIEPCVAYSPASHASKIRTVSPEINAFKKDIMQRHSNVFVDQSGTLEEEGSEWETASHPEDQDSSYSPDGSDPSVEKDHQDSNVSRTFCSVPTRQLKKASSISRLWRSYPSNSDNYKIISVEGMNGRLSNGRLSNGALISSECGSGKDGLSPPDMAGQWSSPEAGNPHITKGMKGCIEWPRSAQKNSLKSKLLEARMESQKVQLRHVLKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCZ7</accession>
    <name>A0A068UCZ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7705 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021422001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCZ7"/>
    <dbReference type="FunCoup" id="A0A068UCZ7">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCZ7"/>
    <dbReference type="Gramene" id="CDP06064">
        <property type="protein sequence ID" value="CDP06064"/>
        <property type="gene ID" value="GSCOC_T00021422001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCZ7"/>
    <dbReference type="OMA" id="HRTDMEN"/>
    <dbReference type="OrthoDB" id="1901892at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056122">
        <property type="entry name" value="DUF7705"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33916">
        <property type="entry name" value="EXPANSIN-LIKE EG45 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33916:SF7">
        <property type="entry name" value="NEPROSIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24804">
        <property type="entry name" value="DUF7705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7705" evidence="1">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="464" mass="53806" checksum="CC9D17EC2706DE25" modified="2014-10-01" version="1">MKRDGLRVAIEAWNQCNEVHKEAPQMGSPRRADCFDLHKHTCPTSHVKLVHKVKKKDNKLGIANARAQGFKNISVDHYAAWKELFLGKKCQVKDKPRPWQFWMIMLKSGNTDTLAAICRKDGKKSKPFPPGPRFPCFGKGCMNMPRIYHQYTKVQKHKKHRKNLRGSFFGTWDLDMDIKNAACRNDTSYYSVVWKKKIGKGSWVFHHLLKTSSKYPWLMLYLRSDATRGFSGGYHYQTRGMSKIIPKSPHFKVKFTLKIKRGGGRNSQFYLMDIGSCWKNNGKRCNGDVTTDVTRYSEMIINPSTQSWCKPSDISKCPPYHTFPNGTRVHRGDKERFPYDAYHLYCAPGNAKYLEEPYNLCDHYSNPQPQEILQILPHPVWGDYGYPTRKGEGWIGDARTWELDVGRLSQSLHFYQDPGTKPAKRHWPSVDLGTEIYLSGNEIAEWSVSDFDIIVPKKHYRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD51</accession>
    <name>A0A068UD51_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00023359001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD51"/>
    <dbReference type="FunCoup" id="A0A068UD51">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD51"/>
    <dbReference type="Gramene" id="CDP06490">
        <property type="protein sequence ID" value="CDP06490"/>
        <property type="gene ID" value="GSCOC_T00023359001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD51"/>
    <dbReference type="OMA" id="QSFMCVG"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000042">
        <property type="entry name" value="Envelope ADP,ATP carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="89"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="279"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP06490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="392" mass="42860" checksum="273E241DF81863A8" modified="2014-10-01" version="1">MKKSQVSLSCREIPALKSSNVPISSSIVEPEFYLLQTNRSSHTGTSTRLRGNVSNFASLSMEEKKEERAFYPTSNQLLKRPLALLALVPKDAALFAAGAIAGAAAKTVTAPLDRIKLLMQTHGVRVGQEGVRKGIGFIEAITLIGKEEGIKGYWKGNLPQVIRIIPYSAVQLFAYETYKKLFSGKDGTLSVIGRLAAGACAGMTSTFVTYPLDVLRLRLAVEPGYKTMTQVAFNMLKEEGVASFYSGLGPSLIGIAPYIAVNFCVFDLVKKALPEEYQKRTETSLITGLISATVATVMCYPLDTVRRQMQMRGTPYKTVLDAFPGILERDGLVGLYRGFVPNALKTLPNSSIRLTTFDTVKRLIVASEKELQKIILENRNKEGQSSSEGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE14</accession>
    <name>A0A068UE14_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00021189001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE14"/>
    <dbReference type="STRING" id="49390.A0A068UE14"/>
    <dbReference type="Gramene" id="CDP05878">
        <property type="protein sequence ID" value="CDP05878"/>
        <property type="gene ID" value="GSCOC_T00021189001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE14"/>
    <dbReference type="OMA" id="NYYCTSY"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE14"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF175">
        <property type="entry name" value="BETA-GLUCOSIDASE 18-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31473" checksum="1CB23826E65E36FA" modified="2014-10-01" version="1">MQPKQGGVIGIVVNAFMYEPLTDDERDKEAANRALAFNVAWNLDPPVFGDYPPEMRRYLRNELPKFTSEERLLIRDSIDFLGLNHYGTLYAKDCTRSSCACSGSACVAGGDRAIRGFVSTTEERDGVLIGEPTGLPICYVVPRGMEELVDYIKNRYHNKPIFITENGYSPPQQEDQLDDLLDDKRIEYHKAYLASLARAMRSGADVRGYFIWTLMDDFEWTLGYGVKFGLCSVDRTTLNREPRSSAEWYRNFLRKSPRSNNNNNNTERRPTFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEK3</accession>
    <name>A0A068UEK3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00024079001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEK3"/>
    <dbReference type="Gramene" id="CDP07000">
        <property type="protein sequence ID" value="CDP07000"/>
        <property type="gene ID" value="GSCOC_T00024079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEK3"/>
    <dbReference type="OMA" id="MDVEKQW"/>
    <dbReference type="OrthoDB" id="610577at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEK3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33320">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33320:SF34">
        <property type="entry name" value="ZINC-RIBBON 15 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7701" checksum="A2D9E36BDFA2B68F" modified="2014-10-01" version="1">MCLVFVCDEDERVLARQIAPGACPYCGGMVQALDVEKEWRFCFVPLYFKAKRKYFCTICARRLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGJ9</accession>
    <name>A0A068UGJ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023687001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGJ9"/>
    <dbReference type="STRING" id="49390.A0A068UGJ9"/>
    <dbReference type="Gramene" id="CDP06738">
        <property type="protein sequence ID" value="CDP06738"/>
        <property type="gene ID" value="GSCOC_T00023687001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGJ9"/>
    <dbReference type="OMA" id="RTHHMEK"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGJ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12637" checksum="15EE659CD6C31CE4" modified="2014-10-01" version="1">MDAANRRQIVVRLLLAAEYEAQQIVNAAKTERVRKLTQAKEEAEKEVAGHHREMELEFRKNEAENSGELRAIIKRLEQETEGKINHLQMEAASVRNGIASMLFKHATTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHI4</accession>
    <name>A0A068UHI4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4220 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00026705001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHI4"/>
    <dbReference type="STRING" id="49390.A0A068UHI4"/>
    <dbReference type="Gramene" id="CDP08030">
        <property type="protein sequence ID" value="CDP08030"/>
        <property type="gene ID" value="GSCOC_T00026705001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHI4"/>
    <dbReference type="OMA" id="WIDHRND"/>
    <dbReference type="OrthoDB" id="1689146at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHI4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025315">
        <property type="entry name" value="DUF4220"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007658">
        <property type="entry name" value="DUF594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31325">
        <property type="entry name" value="OS01G0798800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13968">
        <property type="entry name" value="DUF4220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04578">
        <property type="entry name" value="DUF594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4220" evidence="2">
        <location>
            <begin position="52"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="637" mass="73014" checksum="87301C31D3697752" modified="2014-10-01" version="1">MASLISDTVKRLWDEWNLRAAVLISLFFQMVLISLATFRKRTGNRIVNAIIWSVYLLADWLAAFAVGLISNGQSNDNPDKFRVNEELAAFWAPFLLLHLGGPDNITAFSLEDNELWIRHLLGLVIQLVAVAYVFAQSIHTDLSVPTILLFFAGAIKYAERTRALYLGCLGSQTSEIRGETDWTTEQNPHLDVVQTGYEFFTTFRGLIVDHMFSFHERNKSRNFFSRRSARDAFRVIEVELNFMYDSLYTKMAVVHSNIGYVFRFICSVLIVLSLVEFASHHSPEINHFDVAVTYILLYGAVGLDLVALIKVIFSDWTVVVLKNRRVKRIVSAVRDTLSSDRRWSNTISQYNLINFCLNQRWRWLDIAAETIGLKAVLDEMKYKKDFFIQDNLKEFIFQELKGKARKAETNKVAKEIYSARGKRALPDYICYRSSTMSSSVSEEVDYDESLLLWHIATELCYSTSPGDKNSNREFCKLISDYMLYLLVMRPTMMSAVAGIGQIRFQDTCEEAKKFFSRESSSATRQRVACEKLLNVNTDVEPIYVKGDRSKSVLFDACRLAKDLRNLEDDQRWEIMSKVWVELLSYAASHCRPNAHAQELSKGGELITFVWILMAHFGLGEQFRIEAGHARAKLIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHM4</accession>
    <name>A0A068UHM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00026764001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHM4"/>
    <dbReference type="FunCoup" id="A0A068UHM4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHM4"/>
    <dbReference type="Gramene" id="CDP08065">
        <property type="protein sequence ID" value="CDP08065"/>
        <property type="gene ID" value="GSCOC_T00026764001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHM4"/>
    <dbReference type="OMA" id="YCKVPLC"/>
    <dbReference type="OrthoDB" id="636773at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009723">
        <property type="term" value="P:response to ethylene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009751">
        <property type="term" value="P:response to salicylic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1020.10:FF:000004">
        <property type="entry name" value="BTB/POZ and TAZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000012">
        <property type="entry name" value="BTB/POZ and TAZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044513">
        <property type="entry name" value="BT1/2/3/4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46287">
        <property type="entry name" value="BTB/POZ AND TAZ DOMAIN-CONTAINING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46287:SF1">
        <property type="entry name" value="BTB_POZ AND TAZ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="95"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="7">
        <location>
            <begin position="269"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46278" checksum="E01BE99F2B984CD3" modified="2014-10-01" version="1">MASLDLDTPWLASSIESFDGSLDIHIEEVSSSASLDSLDKSKSIIHCSQTIPKPPPLPAKICQRTKNQRCLSKSCFVPKETKDLWDRLFREGYAADVYIITENGSVIPAHYSVLCVASAVLENFLQQSKAKNGIRYIKIPGLPYDAIYVFIRFLYSSCYDEGEMKKFVLHLLVLSHSYSVPSLKKVCVDLLEQRWLTTENVIDVLQLAKNCDAPRLSLICVRMIVKDFKTISLTEGWKVMKRANPSLEQELLESVVEADSRKEERLKKIEEKKVYLQLYEAMEALLHICKEGCRTIGPSDKVLKGSQVSCPFPACKGIETLVRHFSSCKTRVPGGCMQCKRMWQLLELHSRMCSEPDLCKVPLCRHFKEKMQQQSKKDEAKWKLLVSKVMATKNAFGPFMSRRSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIS3</accession>
    <name>A0A068UIS3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein JASON-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027188001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIS3"/>
    <dbReference type="FunCoup" id="A0A068UIS3">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIS3"/>
    <dbReference type="Gramene" id="CDP08376">
        <property type="protein sequence ID" value="CDP08376"/>
        <property type="gene ID" value="GSCOC_T00027188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIS3"/>
    <dbReference type="OMA" id="MACFLDC"/>
    <dbReference type="OrthoDB" id="1932581at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIS3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007142">
        <property type="term" value="P:male meiosis II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039300">
        <property type="entry name" value="JASON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33318">
        <property type="entry name" value="ASPARTYL/GLUTAMYL-TRNA(ASN/GLN) AMIDOTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33318:SF7">
        <property type="entry name" value="PROTEIN JASON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54940" checksum="29A2799BCF902026" modified="2014-10-01" version="1">MGCFFNCFGVNKDSSPSSGSNLEDSSSSATTPAVKVGSVTRNRSPLSSLLLAEEDKDGTPCKLKEEQELGTPKPEIGLNLKELKDEAKFLKACGTLPETPVEIRQASEKWKDLSAQKGDHEHSKFRSWLTNTSAEKLNLEMNSDQPLTPTKHCERWVKLSDSLDHTPSSCLTEGLNAGRVSNSSVEGNETKNAGSVELIASPSHSLTGSSVPKDITPIIIGKNKSVRFDCDSDTSSVTTKSCPSETSSQSLKQSGSSSNLSIAKFSPYPTPLKLSDEMQTPGTVFPAYLDVMGQGKNTRIRSQYVYSVLNPAENMSQWKDLKNEDVNDYQSSHSRQSCREIDQETSASEVGTGRTSVGQELKVEASLSSWLRATFPNPDGPVVNNGSSTSEKSQRGRTPGDRPILGMVAAHWNDDEHQVSPKWWDGNGIPNSTNKYKEDQKVSWHATPFEERLEKALSEETFNLQRNQTSGTPPPDLNETEEDDTALSQLQPSNHFKSVVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJT6</accession>
    <name>A0A068UJT6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trihelix transcription factor ASIL2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027889001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJT6"/>
    <dbReference type="STRING" id="49390.A0A068UJT6"/>
    <dbReference type="Gramene" id="CDP08790">
        <property type="protein sequence ID" value="CDP08790"/>
        <property type="gene ID" value="GSCOC_T00027889001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJT6"/>
    <dbReference type="OMA" id="HMKLARM"/>
    <dbReference type="OrthoDB" id="2019351at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044823">
        <property type="entry name" value="ASIL1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307:SF50">
        <property type="entry name" value="SEQUENCE-SPECIFIC DNA BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13792" checksum="A1371FEF7CF927F5" modified="2014-10-01" version="1">MREEAIFRRNFSAMAAAAVAVAEEDKDEEESDTSSAAAVRLGSGGMRRKKRRRAAGKVVAKGYRKLAETMGGFADIYERVKEAKQRQMVELEKQRMQFANDLEIQKMKLFMESQVQLEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJV3</accession>
    <name>A0A068UJV3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00027564001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJV3"/>
    <dbReference type="STRING" id="49390.A0A068UJV3"/>
    <dbReference type="Gramene" id="CDP08577">
        <property type="protein sequence ID" value="CDP08577"/>
        <property type="gene ID" value="GSCOC_T00027564001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJV3"/>
    <dbReference type="OMA" id="HDHFMLS"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJV3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF300">
        <property type="entry name" value="EXOSTOSIN GT47 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="7">
        <location>
            <begin position="179"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="509" mass="58464" checksum="BB8A4B26AE638AC8" modified="2014-10-01" version="1">MLSPQRKLHLFSPLLSFSSTVVLLFFIPLDLISIIACILGPEKSFLPISAQFAWSYARFYSSYSHKSFNEEFKYDYLDREAEVPSNLSIINSAFHQKVKQIREASLPEPSISKVSSSAFNKRYNKLERLETMLSKARYSIREAAKNGSMISTHEDADYVPHGPMYINANGFHRSYLEMEKSFKVYVYQEGEPPMFHDGLCKSIYSTEGRFIHEMEKGNFYRTKNPDDALVYFLPFSVVAMVQYLYEPGGHDRQAIGHTLADYIGLISGKHPFWNRSLGADHFMLSCHDWGPYSTSYVPQLFNNSIRVLCNANTSEGFNPLKDVSLPEIHLRTGEITGLIGCPSPSRRPILAFFAGRLHGHIRYLLLEQWKEKDQGIQVYDSLPAGVSYESMLRKSKFCLCPSGYEVASPRVVEAIYAECIPILISDSYAPPFSDVLNWKSFSVEVAVKDILNIKKILTSISQTQYRRMHRRLKQVQRHFVINGPPKRFDLFHTIMHSIWLQRLNIQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKA2</accession>
    <name>A0A068UKA2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028128001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKA2"/>
    <dbReference type="FunCoup" id="A0A068UKA2">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKA2"/>
    <dbReference type="Gramene" id="CDP08975">
        <property type="protein sequence ID" value="CDP08975"/>
        <property type="gene ID" value="GSCOC_T00028128001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKA2"/>
    <dbReference type="OMA" id="CINDVRI"/>
    <dbReference type="OrthoDB" id="749576at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKA2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35304:SF1">
        <property type="entry name" value="OS05G0120300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35304">
        <property type="entry name" value="OS05G0120300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="163" mass="17809" checksum="CBF2C46704F125CE" modified="2014-10-01" version="1">MASTCISNCVDAKAPVRATYVNLYKWPESDVEFVRSLSSNGRKNGGGHGGAAGLMHPTVVDSISCRQLYLRSYTFSRDDELNVAKRKRSCRRFRDRVSAANKRKRKLRGGGGSSCSSHGCEGGAGGRRKKRTGFRRAKEMSCVALAAIFRRLLSCTTKVDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKV4</accession>
    <name>A0A068UKV4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028293001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKV4"/>
    <dbReference type="FunCoup" id="A0A068UKV4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKV4"/>
    <dbReference type="Gramene" id="CDP09096">
        <property type="protein sequence ID" value="CDP09096"/>
        <property type="gene ID" value="GSCOC_T00028293001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKV4"/>
    <dbReference type="OMA" id="NWEASVS"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKV4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF61">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="282" mass="32168" checksum="56577ECB15BEB951" modified="2014-10-01" version="1">MHGFAPSLTPFRNFLAVKPLLFSEAQSKFLVPDCSKFIVIKQPGFSHTLSCRNYYCYGERRNKRCASVRASRRESPYEVLGVSPSATPNDIKRAYRKLALKYHPDVNKEANAQERFMRIKHAYNTLLNKSDRRFDKGNRGSESSYSTAGRNDNWTVNNDEEFYGFGNFLRDVQISIEDFFKDLQEEFRNWEAGADSQGKPKSLWEELAEIGEEFVEFLEKELNISDVEAEQTKGNQQQWGNASYGSKETGNVNQNGADNSGIEENINDIEAALAQLKKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULI2</accession>
    <name>A0A068ULI2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00028609001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULI2"/>
    <dbReference type="FunCoup" id="A0A068ULI2">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09301">
        <property type="protein sequence ID" value="CDP09301"/>
        <property type="gene ID" value="GSCOC_T00028609001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULI2"/>
    <dbReference type="OMA" id="DEMVIRD"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULI2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000381">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF533">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="598"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="671" mass="76419" checksum="052D0777B1FAD75B" modified="2014-10-01" version="1">MNTRELRSLSSRSRDFFYASLSNALSSATNQRNLRRIHSLIITLGLHNSVLFSGKLISKYSQFKDPLASLSIFGQSSHKKNVYLWNTIIGAMTLIRKALDFYTLMRELRIVSDNYTLPSVINSCANLLDFETAKLVHDHVLEVDFGSDLYICNALIDMYSRLNNLDRARNVFDGMSKRDLITWNSLISGYSSNGYWDEALEFFYKLRMVGLIPDCFTVSSVLPACGGLMEVVKGQLIHGLVEKIGVMRDVIVSNGLLSMYFKFDKLVDCEKVFNKMDVRDTVTWNTMICGFCNSSLYDESIRLLFQMVHDFEPDTITLSSVLQACGHVRYLKSGRSVHDYMVKNRYTGDITANNLLINMYTKCGELLASREVFDIFKLMKTKDVISWTALISAYGMYGERMKALKVFQKMKKVGIVPDHVVFVAILFAFSHSGLVQEGWDCFYQMKNDYSIEPRKEHYACMVDLLSRSGLLAEAEDFILLMPQKPDASIWGALLSACRSSGDIKIAERVSKRLLELNSDDPGYHVLASNVYAALGKWDKVKIIRKSLRARGLKKQPGFSWLEIQNRVYIFGTGHRFFEQYKELHDFLVVLSDLMAKEGYVADLRFALHDVEDDEKVEMLSGHSERLAIAFGVLNTEPGSPLQIMKNLLILVRDANRFHLFKDGTCSCGDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULU2</accession>
    <name>A0A068ULU2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00027582001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULU2"/>
    <dbReference type="FunCoup" id="A0A068ULU2">
        <property type="interactions" value="1417"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULU2"/>
    <dbReference type="Gramene" id="CDP08588">
        <property type="protein sequence ID" value="CDP08588"/>
        <property type="gene ID" value="GSCOC_T00027582001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULU2"/>
    <dbReference type="OMA" id="MNEKMFE"/>
    <dbReference type="OrthoDB" id="730418at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULU2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044646">
        <property type="entry name" value="EMB1417-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46782">
        <property type="entry name" value="OS01G0757700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46782:SF1">
        <property type="entry name" value="OS01G0757700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="35192" checksum="A3852C279EC40C98" modified="2014-10-01" version="1">MLCLRFTPVSFTKWWEPVQFHRMNKNVVVCAAKGPRPRYPRVWKTRRKIGTISKSIKLVECIKGLSNVKEEVYGALDSFIAWELEFPLITVKKALKTLENEKEWKRIIQVTKWMLSKGQGRTMGTYYTLLNALAEDGRLDEAEELWTKLFSENLESMPRLFFEKMVSIYYRREMHDKMFEVFADMEELGVTPTRSIVKMIGDVFQKLGMMDKCLKLNKKYPPPKWVYRYIKGKRVRIKATDLYDSDRNSVGDSDDDANSASSGSTENTDIQMDEQGEVDHHQNQATDVRSLESVKPIESKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMH7</accession>
    <name>A0A068UMH7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027918001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMH7"/>
    <dbReference type="Gramene" id="CDP08813">
        <property type="protein sequence ID" value="CDP08813"/>
        <property type="gene ID" value="GSCOC_T00027918001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655042" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8883" checksum="9D9DF91616D602F0" modified="2014-10-01" version="1">MIFCSFMLSACCYILQIEFCMQPGQVTKVSGLLSDFLVFTCEQVLAHICNKDFFSLGFVTAWHHKLDVLIHNCLNNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNR5</accession>
    <name>A0A068UNR5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028466001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNR5"/>
    <dbReference type="FunCoup" id="A0A068UNR5">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNR5"/>
    <dbReference type="Gramene" id="CDP09228">
        <property type="protein sequence ID" value="CDP09228"/>
        <property type="gene ID" value="GSCOC_T00028466001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNR5"/>
    <dbReference type="OMA" id="RLLAMYV"/>
    <dbReference type="OrthoDB" id="2019753at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47880">
        <property type="entry name" value="OS05G0353300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47880:SF1">
        <property type="entry name" value="OS05G0353300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41397" checksum="BA019419ECD6E2A6" modified="2014-10-01" version="1">MNEKLSARELQLVLVYFSQEGRDSWCALELIERKSDIGDVVALLVDMDCVGLKPSFSMIEKVISLYWETGEKDGAVLFVKEVLRRGIAYSDDNREEHKGGPIGYLAWKMMAEGNYKDAVNLVIDMRECGLKPEMYSYLIAMTAVVKELNEVAKALRKLKGFTKAGLIAELDAENTGLVEKYQADLLDAGVRLSNWVMQEGGPSLYGIVHERLLAMYVCSGRGAEAERQLWEMKLVGKEADKDLYDIVLAICASQKEAGAIGRLLTRMEVTSALRKKKTLSWLLRGYLKGGHFDDAAETVIKMLDLGLCPEFLDRAAVLQGLRRRIQQSETLETYLKLCRRLSEASLIGPCMVYLHLKKHKLWIMKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPA6</accession>
    <name>A0A068UPA6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00030748001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the NAD-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Catalyzes the last reduction step in the de novo synthesis cycle of fatty acids. Involved in the elongation cycle of fatty acids which are used in lipid metabolism. Required for normal plant growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPA6"/>
    <dbReference type="FunCoup" id="A0A068UPA6">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPA6"/>
    <dbReference type="Gramene" id="CDP10132">
        <property type="protein sequence ID" value="CDP10132"/>
        <property type="gene ID" value="GSCOC_T00030748001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPA6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPA6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.400:FF:000001">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000192">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.400">
        <property type="entry name" value="Enoyl acyl carrier protein reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004957">
        <property type="entry name" value="PRK06300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159:SF8">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] 2, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="394" mass="42001" checksum="73FEDE12E938EAE6" modified="2014-10-01" version="1">MAANTTAGSQIAVPKPFISASQRILKSSIANFGNETKGESWTKLKCTSHISSTWPFHQKLNSSPLKCQRIVTKAMSATSDKEPLPGLSIDLRGKRAFIAGVADDNGYGWAIAKSLAAAGAEILVGTWVPALNIFETSLRRGKFDESRVLPDGSLMEITKVYPLDAVFDSPEDVPEDVKSNKRYAGSTNWTVKEVAECVKQDFGTIDILVHSLANGPEVSKPLLETSRNGYLAAISASSYSFVSLLKHFVPIMNPGGATISLTYIASERIIPGYGGGMSSAKAALESDTRVLAFEAGRKHRVRVNTISAGPLRSRAAKAIGFIDMMIDYSLENAPLQKELSAEEVGNAAAFLASPLASAVTGAVIYVDNGLNAMGVGVDSPVFKDLDIPKDNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPN0</accession>
    <name>A0A068UPN0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00030905001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPN0"/>
    <dbReference type="FunCoup" id="A0A068UPN0">
        <property type="interactions" value="1513"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPN0"/>
    <dbReference type="Gramene" id="CDP10242">
        <property type="protein sequence ID" value="CDP10242"/>
        <property type="gene ID" value="GSCOC_T00030905001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPN0"/>
    <dbReference type="OMA" id="YPFYKIN"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPN0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF60">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE LPAT1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="203"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP10242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="368" mass="41335" checksum="BCE78808E7764249" modified="2014-10-01" version="1">MVVSYQSSSKFANFQFHPSPPLDHFRQKPAGFFLCTSVRPKSNAHNRFRFGLFPLKHSTWRISNIYDFTSKRRCAHASRLSFFPVEKFCGVYDECVSDRCKLSRCIIRSDISASCSASASYPLSESQAISKFRGICFYAVTSFVAIFLFVLMVVAHPFVLLFDKYRRKAQHLIAKVWALLTISPFLKIEFEGLHNLPAKDAPAVYVSNHQSFLDIYTLLTLGKSFKFISKTSIFLFPIIGWAMYFLGTIPLKRLDSRSQLDCLKRCMDLVKKGASVFFFPEGTRSKDGKLGTFKKGAFSVAVKTGVPVIPVTLIGTGKIMPAGMEGRLNPGGIKVVIHPPIEGKDPDFLCSEARKKIADVLIREGYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPQ5</accession>
    <name>A0A068UPQ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030836001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPQ5"/>
    <dbReference type="FunCoup" id="A0A068UPQ5">
        <property type="interactions" value="1687"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPQ5"/>
    <dbReference type="Gramene" id="CDP10194">
        <property type="protein sequence ID" value="CDP10194"/>
        <property type="gene ID" value="GSCOC_T00030836001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPQ5"/>
    <dbReference type="OMA" id="RANKISC"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPQ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF167">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="70"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="292" mass="33242" checksum="2D22C3CAA7508F71" modified="2014-10-01" version="1">MGNVTSNVAAKFAFFPPDPPTYDVYKDEDGKYICSGLTADKNVDVHVLETKVGNKIVATFWKHPFGRFTLLYSHGNAADLGQMQELFIELRAHLRVNIMGYDYSGYGASSGKPSEFNTYYDIEAVFDCLKNEYGIKQEDIILYGQSVGSGPTLHLASRQHRLRAVVLHSAILSGIRVLYNVKMTFWFDIFKNIDKIRNVSCPVLVIHGTSDDIVDWSHGKRLWELSREKYDPLWVQGGGHCNLETFPEYIKHLRKFMKAMEKHSFSKRSKANLAPTSSITEGKYKCLRLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPV1</accession>
    <name>A0A068UPV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cold and drought-regulated protein CORA-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030927001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPV1"/>
    <dbReference type="STRING" id="49390.A0A068UPV1"/>
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        <property type="protein sequence ID" value="CDP10259"/>
        <property type="gene ID" value="GSCOC_T00030927001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPV1"/>
    <dbReference type="OMA" id="HPAKTVE"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="10440" checksum="870FAE548D257CB0" modified="2014-10-01" version="1">MITSEVAAKSVDNSKTVETKEEGEAKYHGGGYGGHHGGGYGGGHGGYGGGGHGGHPAKTVETNEEGEAKYHGGGYGGHHGGGYGGGHGGHGGGGHGGHPGEAADAEPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQ60</accession>
    <name>A0A068UQ60_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00031333001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQ60"/>
    <dbReference type="FunCoup" id="A0A068UQ60">
        <property type="interactions" value="1794"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQ60"/>
    <dbReference type="Gramene" id="CDP10571">
        <property type="protein sequence ID" value="CDP10571"/>
        <property type="gene ID" value="GSCOC_T00031333001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQ60"/>
    <dbReference type="OMA" id="LLCEMRF"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQ60"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000002">
        <property type="entry name" value="HscB mitochondrial iron-sulfur cluster co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000082">
        <property type="entry name" value="Iron-sulfur cluster co-chaperone protein HscB, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="296" mass="33407" checksum="92A8EDB819166AA8" modified="2014-10-01" version="1">MWKKLHSLAPLSTNLLHRGSASVPYPSATTADPFSSEITSKRSSLSQFSSLLLSPPQFQIEGNYCYSFHSPPSSRVFQTPRLHSGLHGLNSGFFCSIASSPAANSKCWNCNAVASSAVPFLVCHGCRSVQPPDPSIDYFQILGVEKKYDVKVENLEGKYKDWQKKLHPDLVHTKSKKERDFAAEQSARVTDAYRTLSDTLSRAVYLLKLEGLEVDEEGRISDPELLAEIMEIREAVEEAAETQALNHIQAQIWKKLEHWSKSFADAFQSRKYEEAISSIQRMTYYKRANEEIIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQI5</accession>
    <name>A0A068UQI5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030348001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQI5"/>
    <dbReference type="Gramene" id="CDP09868">
        <property type="protein sequence ID" value="CDP09868"/>
        <property type="gene ID" value="GSCOC_T00030348001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQI5"/>
    <dbReference type="OMA" id="YHQYEPE"/>
    <dbReference type="OrthoDB" id="843893at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36595">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36595:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="168" mass="18960" checksum="0B351020A795F01D" modified="2014-10-01" version="1">MKFGLELIFLLIILVGAATHLVLLSCSLSPYGGLVERSTSRAFVFILFNTIMSSILVKSYRPSAEYYTEFLPCGDFYDQAEEKQSEEMIRDDIESSSASSSDSDDDEEEKEEDDDDDDSDGNDEIGWGNDDEEYDETLESRIEAFIAKVISGWKEELLADKLDCKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQP3</accession>
    <name>A0A068UQP3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00031523001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQP3"/>
    <dbReference type="Gramene" id="CDP10721">
        <property type="protein sequence ID" value="CDP10721"/>
        <property type="gene ID" value="GSCOC_T00031523001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQP3"/>
    <dbReference type="PhylomeDB" id="A0A068UQP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16845">
        <property type="entry name" value="SQAPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="3">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="17458" checksum="D3AB580E8A113674" modified="2014-10-01" version="1">MAAVGASDNINISEITANMKAEGVQSPEMEAIVKALSDDTIWKTIEGFKGKDMSTQEKMINNMMASGGLAELGIPVPEPVNPDDAHVITIAKFVVEKQNENAGTSLVFIQVNGGLQWKIVIGTLYILFLTTQDSKGTYTDHAVVFETFLGQKYLFWYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URT0</accession>
    <name>A0A068URT0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00031009001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URT0"/>
    <dbReference type="STRING" id="49390.A0A068URT0"/>
    <dbReference type="Gramene" id="CDP10318">
        <property type="protein sequence ID" value="CDP10318"/>
        <property type="gene ID" value="GSCOC_T00031009001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URT0"/>
    <dbReference type="OMA" id="KYYTIAD"/>
    <dbReference type="OrthoDB" id="1858506at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URT0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF70">
        <property type="entry name" value="MAJOR ALLERGEN PRU AR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="17343" checksum="4CB49D89D23C0ABC" modified="2014-10-01" version="1">MAPITYSSEMTSPIPPARLFKAAILDDTLLPKILPQAIKSVEILEGDGGAGTIKLSKFGEANKFKSAKHRVDELDKENFVYSYSVIESDALKEGIEKFTNEIKFEASPNGGSICKTNSSIYTKGDVQITEEEIKGATERALGMFKAVEAYLLANPDAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USC1</accession>
    <name>A0A068USC1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00033697001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USC1"/>
    <dbReference type="Gramene" id="CDP11440">
        <property type="protein sequence ID" value="CDP11440"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="224" mass="24655" checksum="D62886B706542B4D" modified="2014-10-01" version="1">MIPVSCLLEVVFDKIRYSRDTKLSIALVLLGVGVCTVTNVSVNTKGFVAAFIAVWSTSLQQYYVHFLQRKYSLSSFNLLGHTAPAQAASLLLVGPFLDYWLTNKRIDAFNFNVPSLVFIVLSCTIAVGTNLSQFICIGRFTAVSFQVLGHMKTILVLILGFLFFGKEGLNLHVVIGMIIAVVGMVWYGNASSKPGGKERHSHSSRSSQQKHGSESSITKVRRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUZ2</accession>
    <name>A0A068UUZ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00035507001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP12117"/>
        <property type="gene ID" value="GSCOC_T00035507001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUZ2"/>
    <dbReference type="OMA" id="FFEGCHY"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUZ2"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000234">
        <property type="entry name" value="Probable inactive receptor kinase RLK902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF6">
        <property type="entry name" value="OS01G0223600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655128" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="27"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="331"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP12117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="635" mass="69943" checksum="55F2E72D70462323" modified="2014-10-01" version="1">MERQRLYIFSLISSALFLLSQGIVRATLVGNDKQALLDFEKKLPHLRSLNWDENSPVCKNWTGVSCNEDGSRVISLRLPGVGFHGPIPTNTLSRLSALQILSLRSNFINGTFPLDLGKLRNLSYLYLQFNNFTGPLPRDFSVWKNLTGINFSNNGFNGSIPSSISSLRQLSSLNLANNSLLGEIPDLNLPNLQLLNLSNNNLSGAVPKSLQKFPKSAFLGNNASLLEYSVTSSPAVSLPKEPILKSKSTAKLSERALLGIIIAVSVLGLLGFAFLLLVCLLRRKIEDGFPGKLEKGNMSPEKVISRSQDANNKLVFFEGCNYAFDLEDLLRASAEVLGKGTFGTAYKAILEDATMVVVKRLKEVGVGKREFEQQMGVVGSIKHENVIELRAYYYSKDEKLMVYDYHSQGSLAAMLHGKRGENRPPLDWETRLRIAVGAARGIARVHIENGGKLVHGNVKSSNIFLNSRQYGCVSDLGLSTVMSSLALPIARAAGYRAPEVMDTRKATQSSDVYSFGVMLLELLTGKSPIHTTSGDEIVHLVRWVHSVVREEWTAEVFDLELLRYPNIEEELVEMLQIAMACVVRMPDQRPKMSEVAKMIANVRPTAIRNRSSGELKTGNSSQTPPVGVSETDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWM7</accession>
    <name>A0A068UWM7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="4 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00036374001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 9"/>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWM7"/>
    <dbReference type="FunCoup" id="A0A068UWM7">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWM7"/>
    <dbReference type="Gramene" id="CDP12659">
        <property type="protein sequence ID" value="CDP12659"/>
        <property type="gene ID" value="GSCOC_T00036374001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWM7"/>
    <dbReference type="OMA" id="FNDLENH"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWM7"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01598">
        <property type="entry name" value="PurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000003">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000004">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047136">
        <property type="entry name" value="PurB_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006764">
        <property type="entry name" value="PRK09285.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="10">
        <location>
            <begin position="94"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylosuccinate lyase PurB C-terminal" evidence="11">
        <location>
            <begin position="409"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="545" mass="61357" checksum="128707D17FDFBE34" modified="2014-10-01" version="1">MEVEASFRVASRINCKEVPYCNPICNYRTLNLRFPYHHRLPHLSNASVYTLKSCYCKAVAKESSTEVVEKGRKMYSHDIKLSSLTALCPLDGRYWAKVKELALFMSEYGLIRFRVLVEVKWLLKLSQIPEIPEVPSFSKDTETYLQGLIDGFSLDDAMEVKKIEKVTNHDVKAVEYFLKQKCQSHPEIGKVVEFFHFACTSEDINNLAHALMLKEALSMVMIPAMDEVISAISDMAMENAHIPMLSRTHGQPASPTTLGKEMAIFAFRLSWERQDISEVKILGKFAGAVGNYNAHLVACPDINWPQVAEEFVTSLGIDFNPYVPQIEPHDYMAKLFHSIIQFNNILVDFDRDIWGYISLGYFKQITKAGEIGSSTMPHKVNPIDFENSEGNLGVANGGLSHLSMKLPISRWQRDLTDSTVLRNMGVGLAHSLLAYRNALMGIGKLQVNEASLSEDLNHTWEVLAEPIQTVMRRYGVPEPYEKLKEVTRGRVVTQESMREFIKNLDIPGDAKMMLLNLTPQTYVGAAAELAKNIKTAINLVNGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX72</accession>
    <name>A0A068UX72_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00037968001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX72"/>
    <dbReference type="FunCoup" id="A0A068UX72">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UX72"/>
    <dbReference type="Gramene" id="CDP13135">
        <property type="protein sequence ID" value="CDP13135"/>
        <property type="gene ID" value="GSCOC_T00037968001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX72"/>
    <dbReference type="OMA" id="GLMRMID"/>
    <dbReference type="OrthoDB" id="1864232at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="16687" checksum="4F31A7948AEA2685" modified="2014-10-01" version="1">MKQEKLSHFRFYWHDILSGTTPTSVRVVAPPKTASFTGFGAVNMIDNPLTLGPNLSSKVVGRAQGFYASASQEEVGLLMTMNFAFTEGKYNGSTITVLGRNPVFNKVREMPVIGGSGDFRFSRGYAQATTYFFDPKSGDAVVEYNVYVMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXX7</accession>
    <name>A0A068UXX7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00038125001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
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    </dbReference>
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            <end position="674"/>
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            <end position="160"/>
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    </evidence>
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    </organism>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
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                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
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                <person name="Ming R."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V033"/>
    <dbReference type="STRING" id="49390.A0A068V033"/>
    <dbReference type="Gramene" id="CDP14145">
        <property type="protein sequence ID" value="CDP14145"/>
        <property type="gene ID" value="GSCOC_T00040382001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V033"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V033"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium-transporting P-type ATPase N-terminal autoinhibitory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="125" mass="14311" checksum="B72B3EF49AB23C77" modified="2014-10-01" version="1">MEKLLKEFNVPAKHGSEEELSLWRNHVTPVKNSRRRFRYVANLDKRSAVQEQKAKIGEKLQACFVLYMEELKSTDAGDVLYEWAREAEETLQEDKEKEFLNEASAAGCGSESSQLPLPMISSTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0B7</accession>
    <name>A0A068V0B7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039167001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068V0B7"/>
    <dbReference type="Gramene" id="CDP14007">
        <property type="protein sequence ID" value="CDP14007"/>
        <property type="gene ID" value="GSCOC_T00039167001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0B7"/>
    <dbReference type="OrthoDB" id="504467at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0B7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="136" mass="16048" checksum="D9D9AC20295DBCE8" modified="2014-10-01" version="1">MEARKTREGRRLAGVLGRQGERVRLYMRGTILGYKRLQSNQYPNTSLIQIERVNTKEEVAWYLGKKMAYIYKAKVKKNGSHYRCIWGKVCRPHGNMEKFFMRTICVVTDEHDQKMLVERERARCGSEDYTDDVNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0S5</accession>
    <name>A0A068V0S5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Squalene cyclase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00040517001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0S5"/>
    <dbReference type="STRING" id="49390.A0A068V0S5"/>
    <dbReference type="Gramene" id="CDP14236">
        <property type="protein sequence ID" value="CDP14236"/>
        <property type="gene ID" value="GSCOC_T00040517001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0S5"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0S5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF19">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15648" checksum="653A82F26F604177" modified="2014-10-01" version="1">MWKLKVAEGGPWLTTTNGHVGRQHWEFDPEAGSPEERAQVEKIRQEFKKNRFQKKQSSDLLLRMQVGLIQAFYSLSQIKELLSNDLCCKTAESSPQPNEKRKSQILKTTLIRAKMFLTKPTQGSFSLARRHCGAACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0T5</accession>
    <name>A0A068V0T5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040340001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0T5"/>
    <dbReference type="FunCoup" id="A0A068V0T5">
        <property type="interactions" value="1657"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0T5"/>
    <dbReference type="Gramene" id="CDP14114">
        <property type="protein sequence ID" value="CDP14114"/>
        <property type="gene ID" value="GSCOC_T00040340001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0T5"/>
    <dbReference type="OMA" id="DPNIWSA"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0T5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000039">
        <property type="entry name" value="Villin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000028">
        <property type="entry name" value="Villin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="10">
        <location>
            <begin position="890"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="813"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="955" mass="104578" checksum="7261AB7FDDD19490" modified="2014-10-01" version="1">MSSSVKALEPAFQGAGQRIGTEIWRIENFQPVPLPKSDYGKFYSGDSYIVLQTSPGKGGAYLYDIHFWLGKDTSQDEAGTAAIKTVELDAILGGRAVQHRELQGHESDKFLSYFKPCIIPLEGGVASGFKKPEEEEFETRLYVCKGKRVVRLKQVPFSRSSLNHDDVFILDTKDKIFQFNGANSNIQERAKALEVIQFLKEKYHEGTCDVAIVDDGKLQTESDSGEFWVLFGGFAPIGKKVASEDDIIPEKTPAKLYSVVDGQVKPVDDELSKSILENNKCFLLDCGSEIFVWVGRVTQVDERKTAIQAAEEFVVSQNRPKSTSITRLIQGYETHSFKSNFDSWPSGSAPVAEEGRGKVAALLKQQGVGVKGASKSAPVNEEVPPLLEVGGKIEVWCINGSAKTPVPIEDIGKFFSGDCYIILYTYHSHDKKEEYYLCYWIGKDSIQEDQIMAAGLANTMCNSLKGRPVLGRIYQGKEPPQFVAIFQPMVVLKGGVSSGYKNYIADKGLNDETYTPDSVALIRISGTSVHNDIVVQVDAVPASLNSNESFLLQSGSSLFSWHGSQSTFEQQQLAAKVAEFLKPGVAMKHTKEGTESSAFWFALGGKQSYTSKKVTPEVSRDPHLFTFSFNKGSSFSMCLTLKLIEEVYNFSQDDLLTEDVLILDTHAEVFIWVGQSVDAKEKQSAFENGQKYVELAASLEGLSPKVPLYKVTEGNEPCFFTTYFSWDPAKAMAHGNSFQKKVLLLFGASHATEERSNGTNQGGPTQRASALAALNSAFNSTGSAKPTLAARSAGVSQGSQRAAAVAALSSVLTAEKKRSPDSSPARPGRSPTSETGSPASGLKSENSPPDLEDSKEGSEVEAEITELAVQTNGEDSEPKPDSEQDENGGESTQSTFSYEQLKAKSDNPVTGIDFKRREAYLSDEEFEAVLGMTKEAFYKLPKWKQDMLKKKADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V196</accession>
    <name>A0A068V196_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7906 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00040551001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V196"/>
    <dbReference type="FunCoup" id="A0A068V196">
        <property type="interactions" value="2154"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V196"/>
    <dbReference type="Gramene" id="CDP14259">
        <property type="protein sequence ID" value="CDP14259"/>
        <property type="gene ID" value="GSCOC_T00040551001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V196"/>
    <dbReference type="OMA" id="IHCTKER"/>
    <dbReference type="OrthoDB" id="16573at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V196"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057228">
        <property type="entry name" value="DUF7906"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25483">
        <property type="entry name" value="DUF7906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658438" description="DUF7906 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7906" evidence="4">
        <location>
            <begin position="516"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123627" checksum="BEC319AA48B18299" modified="2014-10-01" version="1">MFRLRFNRSFSFFFLLILLLGNGSYGSRVGQRKSGRSSVFSLFNLKEKSRFWSESVLRTDFDDLESSKPDKESAANYTKAGTIGHYLKLFEVDAMYLPVPVNFIFIGFEGKGNQAFKLHAEELERWFTKIDHVFEHSRIPQIGEVLTPFYKISIDREQRHHLPLVSRINYNFSVHAIELGEKVTSIFEHAIDVFGRKDDVLDTRDDVAGLWQVDVDMMGVLFTSLVEYLHLGDAYNIFILNPKREGKRTKYGYRHINLLKENKALQSRIFQSGSVPDSVLALEKIESPSHEKRTMAKFSWTITEDTDTNELESLCIILKSTIVLVGNGPTVHYNLSVGRYVSATRLKTSYKYLVESEVLLAIISWSLSRLLGNVVEVILLILIRIKHSVRILVLKKYIQIQHCLTSSVDGFSFIKHSKHLNVRKGSISTLFYIFLLSIAYPFFVGKTTHSWRVVSFLVEWYNHCLDALNNIERQYQGKDTADIIQSKILQSLRGKYEDLKLLFEKNIKSGDFNGFHAECLTDAWIGKDRWAFIDLTAGPFSWGPAVGGEGVRTDLSLPNVEKTIGAVLEISEDEAEDRLQEAIQEKFAVFGDKDHHAIDILLAEIDIYELFAFKHCKGRRVKLALCEELDERMQDLKNELQSFEGEEYDESHKKKAIDALKRMENWNLFSDTYEGSQNYTVARDTFLAHLGATLWGSMRHIISPSLADGAFHYYEKISFQLFFITQEKTRNIKLLPVDLKSLQDGLSSLVVPSQKVMFSQQMVPLSEDSALAMAFSVARRAAAVPLLLVNGTYRKTVRTYLDSSILQHQLQRLNEHGSLKGSHAHSRSTLEVPIFWFIHGDPVLVDKYYQAKALSDMVIVVQSEESSLESHLQCNGQSLLLDLRRPIKAAMASVAEHLAGLLPLHLVYSQAHETAVEDWIWSVGCNPLSITSQGWHISKFQSDTIARSYILTTLEESIQIVNSAIHLLVVERTSEQTFKAFQSMERELVNKYNYVVSLWRRISTVTAELRYDNAMGLLNTLEDASKGFADYVNSSLATLHPIHCTRQRKVKVEFDVTTVPAFLIVLVVLWVILRPRRPKPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V326</accession>
    <name>A0A068V326_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00040561001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V326"/>
    <dbReference type="FunCoup" id="A0A068V326">
        <property type="interactions" value="1555"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V326"/>
    <dbReference type="Gramene" id="CDP14268">
        <property type="protein sequence ID" value="CDP14268"/>
        <property type="gene ID" value="GSCOC_T00040561001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V326"/>
    <dbReference type="OMA" id="FGNSGMN"/>
    <dbReference type="OrthoDB" id="1725508at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V326"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="427" mass="46390" checksum="1FB7637E7E9751C2" modified="2014-10-01" version="1">MPPKKELCRNFLRGSCQYGDRCKFLHAAQTPARQNPFGLGMQTGNQFQHANLQQQKPNPFGFGVQNSSQPRGAGDFSSKQNQFKAFENKWTRSSQANTGNSAASRQPDNQPPSHKCTDPESCKRQILEDFENERPLWKLTCYGHSKYGPCDIVGDISYEEFRATAYDDAKRGLSLQSIVERERNLLNSKLVEFDSLLRSPYKGLSNSAIGLQSPFPISVRNTSVSAQNSKPPSFSSFSQLGTSLGGGATASPNNFFGQQHAFQSTSQTSSTFKMTNSPFQNSGFGSQLPSQTLQSPFASGSASFGNSSVNTVQNPLFASTVSAQTSTLSNASNNNMKSGFASFSNSSVQNPFSTSAVSSQSSIFGDNTNALFSVNANVNEVGLSAGNIDLKLTTPEENLNGDNSIWRKEEWGIGEIPEAEPPVEYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V381</accession>
    <name>A0A068V381_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-6-phosphate dehydrogenase (NADP(+))</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00042845001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V381"/>
    <dbReference type="STRING" id="49390.A0A068V381"/>
    <dbReference type="Gramene" id="CDP15215">
        <property type="protein sequence ID" value="CDP15215"/>
        <property type="gene ID" value="GSCOC_T00042845001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V381"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V381"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF4">
        <property type="entry name" value="INACTIVE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="119"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45921" checksum="3BA49D3E9F15A3C5" modified="2014-10-01" version="1">MKVGANHVSLTASSRLMAHGRAKKFCNSKEGLGRTSLCPEAVPVSNFALPFRSGMNASSESLSSTGAKAKASSQEEESSEPTSHFNISLKTLNATKSPASLLQSYTPEVGRSPFLSIAVIGATGELARRKIFPALFALYYSGNLPENVAVFGYSRKTLTDEDLRSIIASTLACRIDHQQGCEDKIDAFLRRTYFVDGGYDNREGMLKLTARMEQVEGQFEANRMFYLSVPQEALLDVAFSLSEHAQTQKGWSRIIIEKPFGLDLLSSDQFTRSIHSKFEEKQLYRIDHLLGRNTIENLAVLRFSNLVFMPLWNRNYIDNIQVVWSDDLATHAPSRYLDENGIIGDVVHSHILQTIALLAMEPPITLDGEDVRNEKACDFYIYIYIYIFVIPFSCAKITNLSEGNTLLLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3V3</accession>
    <name>A0A068V3V3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Uridine monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00043032001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="3"/>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3V3"/>
    <dbReference type="FunCoup" id="A0A068V3V3">
        <property type="interactions" value="1430"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3V3"/>
    <dbReference type="Gramene" id="CDP15341">
        <property type="protein sequence ID" value="CDP15341"/>
        <property type="gene ID" value="GSCOC_T00043032001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3V3"/>
    <dbReference type="OMA" id="MSHWPWF"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3V3"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000238">
        <property type="entry name" value="Aspartate/glutamate/uridylate kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000028">
        <property type="entry name" value="Uridylate kinase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833:SF1">
        <property type="entry name" value="UMP KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833">
        <property type="entry name" value="URIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="9">
        <location>
            <begin position="148"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="293"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="530" mass="57655" checksum="C2F857F7C6C0EF3C" modified="2014-10-01" version="1">MASCDDDFSLLGDDNATTSNPNPNLIHHRQSFTHRNLSAPNDDDDDVVSADADGYSDGAFCSSQPNPKLANASNATSFHVVNVNPYDPDPNPFDNEHDPTKSRANNHNHTPNDKRSDREEVSDSGTPYSYKRPRVSSSATGGEYRKDREEWSDTAIACLLEAYTEKFMMLNRGNLRGRDWEEVAVMVSERCEKQTKSVEQCKNKVDNLKKRYKLERHRLSNGGVSASHWPWFKQMEQIVGNSLSGKAATDDDKSVGGTANTGRQSKRYGTTTVSPGPQINSIKSKATSARWRRVVFKISGGTLAGTAPQNIDPKVAMLVAREVSIACRMGVEVAIVVGGRNFFCGHTWVTTTGLDRFAAYQAGMMATVMNSILLQSAFEKLGVQTRVQSAYSMPEVAEPYCRLRAIRHLEKGRVVIFGGIGAGTGNPLFSTDLAAALRASEINADAVLKGTNVDGVFICDSRNNNIAADHICFTDLASGGACPMDMMAIRSCEDNGIPVVIFNLHEPGNISRALCGEQVGTLIDQTGSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4A6</accession>
    <name>A0A068V4A6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00015356001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4A6"/>
    <dbReference type="FunCoup" id="A0A068V4A6">
        <property type="interactions" value="2760"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4A6"/>
    <dbReference type="Gramene" id="CDP15501">
        <property type="protein sequence ID" value="CDP15501"/>
        <property type="gene ID" value="GSCOC_T00015356001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4A6"/>
    <dbReference type="OMA" id="WINQCYE"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4A6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009569">
        <property type="term" value="C:chloroplast starch grain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901982">
        <property type="term" value="F:maltose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009859">
        <property type="term" value="P:pollen hydration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001860">
        <property type="entry name" value="Sucrose nonfermenting 4-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="429"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP15501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="483" mass="53590" checksum="9D9D7B425F26C372" modified="2014-10-01" version="1">MFGGGGGNGLTNSRGAEGGDTILVPTRFVWPHGGRRVFVSGSFTRWTNHIPMSPMEGCPTVFQVVYNLTPGYHQFKFFVDGEWRHDEHQPFVSGNYGVVNTIFLPSESDMVPTFFSPEMPGRSNMDVDNDPFLRVERVPTITQNDIELSRHRISMFLAMHNAYELLPDSGKVIALDVNLPVKQAFHILYEQGISVAPLWDFRNGQFVGVLSALDFIMILQELGNHGSNLTEEELETHSISAWKEGKLNLMRQIDGNLRQYRRRLVHAGPYDSLKDVAVKILENKVATVPIIHSSSQDGSFPQLLHLASLSGILKCICRHFRHSSSSLPILQQPISSFPLGTWVPKIGDSDGKPLAMLSSNASLNAALSLLVQAEVSSIPIVDENDSLQDIYCRSDITALAKDRAYAQIQLSELSIQEALQLGQDANAPYNGQRCQMCLPSDPLHKVMERLALPGVRRLVIVEAGSKRVEGIISLSDVFKFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4C6</accession>
    <name>A0A068V4C6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">indole-3-acetaldehyde oxidase</fullName>
            <ecNumber evidence="17">1.2.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00015550001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.7" evidence="17"/>
    <dbReference type="EMBL" id="HG739185">
        <property type="protein sequence ID" value="CDP15630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4C6"/>
    <dbReference type="STRING" id="49390.A0A068V4C6"/>
    <dbReference type="Gramene" id="CDP15630">
        <property type="protein sequence ID" value="CDP15630"/>
        <property type="gene ID" value="GSCOC_T00015550001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4C6"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4C6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050302">
        <property type="term" value="F:indole-3-acetaldehyde oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009851">
        <property type="term" value="P:auxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006124">
        <property type="term" value="P:ferredoxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000006">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000012">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0937">Abscisic acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0073">Auxin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="18">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="241"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP15630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="864" mass="94146" checksum="088568BADB36B791" modified="2014-10-01" version="1">MEENGTKCPPSEAGNGSLVFAVNGEKFELATLDPSTTLLQFFRYHTRFKSVKLGCGEGGCGACVVMLSKYNPELDQVEDFSVSSCLTLLCSVNGCSITTSEGLGNSKDGFHPIHQRFAGFHASQCGYCTPGMCMSFFSALAKAEKTNRPEPPPGFSKLTVSEAEKAIAGNLCRCTGYRPIADACKSFAADVDLEDLGLNSFWRKGEPKEVKLSRLPLYTPDGRFSRFPEFLKGRSKSPKSLHLENSSWYTPTTLEELRSLLNSNLIENDKLRLVVGNTGMGYYKELDNYDRYIDLRYLSELQTIRRNHHGIEIGAAVTISKVIACLKDADTLNYSTDGKQVFEKLANHMEKIASGFIRNSASIGGNLVMAQRKSFPSDIATILLAVGSIVSITTGHKHESITLEEFLTRPPMDSRSVLLSVQIPHLEPKGNGNNSGSNSKLVFETYRAAPRPLGNALPYLNAAFLADVSHQVSGVLVNNIQLVFGAYGTKHATRARKVEEYLSGRMLSASVLYEAVKLVKVDVMPAVGTSHAAYRTSLAIGFLFQFLSPFLRVGSVACGGLSNGLTGDLLKDSLENHRDTSLCQWEYSKLLLSAKQELKSSKEYHPVGEPITKSGAAIQASGEAVYVDDIPSPPNCLHGAFIYSTKPLARVKGVDLESNNQLSGVAALISYKDIPEQGENVGSKAMFGSEPLFADDLTRCAGQQIAFVVANTQKFADIAANSALVKYDTANLDPPILTIEEAVERSSFFQVPPFLYPKQVGDFSKGMAEADHKILSAEIKLPSQYYFYMETQTALAVPDEDNCMVVYSSIQCPELTHSVIATCLGVPEHNIRVITRRVGGGFGGKAIKAMPVSINNIKIKFFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4D5</accession>
    <name>A0A068V4D5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042107001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4D5"/>
    <dbReference type="STRING" id="49390.A0A068V4D5"/>
    <dbReference type="Gramene" id="CDP14693">
        <property type="protein sequence ID" value="CDP14693"/>
        <property type="gene ID" value="GSCOC_T00042107001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4D5"/>
    <dbReference type="OMA" id="DACLHCE"/>
    <dbReference type="PhylomeDB" id="A0A068V4D5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="121" mass="13343" checksum="B53C518860809FE6" modified="2014-10-01" version="1">MAVANEKPPMSEVKVWSFCRLPFWQSTNNAAAGGGGGSGSSSLQQNHLAAADHQPSIKVASVAKSFLPTRRRLGLDPPNKLYFPCMWANLFSLMHASFSLMLYIYVREAEVVHFDACLHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5K1</accession>
    <name>A0A068V5K1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042742001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739179">
        <property type="protein sequence ID" value="CDP15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5K1"/>
    <dbReference type="Gramene" id="CDP15148">
        <property type="protein sequence ID" value="CDP15148"/>
        <property type="gene ID" value="GSCOC_T00042742001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5K1"/>
    <dbReference type="OrthoDB" id="1936545at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010800">
        <property type="entry name" value="GRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389:SF41">
        <property type="entry name" value="GLYCINE-RICH PROTEIN 3 SHORT ISOFORM-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389">
        <property type="entry name" value="NODULIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07172">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655462" description="Glycine-rich protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11533" checksum="69EEEAE4C099C487" modified="2014-10-01" version="1">MSSMKILFFCICLALVLMIISQVAARELVETSNSVDNSKTDEANGLKEAKYPGGYGGYPEGGYGGYPEGGVWRVSWRRLWGIPRWWIWGLSRRKVWWISWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5S6</accession>
    <name>A0A068V5S6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00042808001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068V5S6">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5S6"/>
    <dbReference type="Gramene" id="CDP15193">
        <property type="protein sequence ID" value="CDP15193"/>
        <property type="gene ID" value="GSCOC_T00042808001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5S6"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="563"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1226"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1271"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1309"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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    <sequence length="1450" mass="163982" checksum="507FC602E10044E7" modified="2014-10-01" version="1">MAQLVETDDIESVRNELSEVERSLRLSLRHLSSSFSSSSVLSTERDGNLNEEIALQWAAIERLPTAQRLRSSLFDQPDDNEAAGKRKMAIDVTKLSALERHMFIERLIKHIEYDNLRLLQNMRKRMNKVGLEFPSVEVRYNDLHVEAVCEVVEGKPLPTLWNSFKSSLPDVTRLPGLESRVSKISIIDGVSGIIKPGRMTLLLGPPGCGKTTLLKALSGNLNKSLKVTGDISYNGYKLTEFVPQKTSAYISQYDLHNGEMTVRETLDFSLRCQGVGSRAEIMTQLSRREKQAGILPDPDIDTYMKASSAEGQKTTLQTDYILKILGIDTCADTLVGDAMRSGISGGQKKRLTTGEMIVGPTRALFMDEISNGLDSSTTYQIVACFQQLAHILDATILISLLQPAPETFDLFDDVILMSEGKIVYHGPRSTAVEFFQSCGFRCPERKGVADFLQEVISEKDQAQYWYSTEETYIYVSLDAFSRKFRESSHGKKLTEQLSTTLVKSKSCKDAMNFTAYSLPKWELFRACLSREFLLMKRNRFVYIFKSVQLFISASITMTIFLRTRMGLDLLHANKYMGVLFFAGGVLVVDGLPELSMTVTRLAVFYKQRDLLFYPAWAYAIPSAILKLPLSLLEAVVWTCLTYYVIGYDPEVGRFFRHLILLFALHMASISMYRFVASVCRTVVVASMVGLLTLLLVFLFCGFIIPRPTMPNWLKWAFWVSPLSYGEIGLTLNEFLSPRWKKMLPTNTSVGQETLDARGLNFDAYFFWISLGALFGFTLLFNLGYTLALTFLNPVSPRAIISREKYFQIQRIKKLDVIAHAEEKLTDPARATATESQNAGKMALPFEPLTVVFQDLQYYVETPLAMKEQGFPEKRLQLLCDITGTFRPGVLTALMGVSGAGKTTLLDVLAGRKTSGYTKGEIKIGGFPKVQRTFARISGYCEQTDIHSPQITVEESVLFSAWLRLHPQIDSKTKIDFVKEVLETIELDGIKDVLVGIPGVNGLSTEQRKRLTIAVEFVANPSIIFLDEPTTGLDARAAAIVMRGVKNVASTGRTIVCTIHQPSIDIFEAFDELILLKSGGRMIYSGPLGRNSSEVIGYFEGIPGVPKIRNNYNPATWMLEVTSTSSEAELGVDFAEIYKHSSLYEINKELANTLSTPPIGHKALDFPTHFAQNGWIQFKTCLWKQHWSYWRSPSYNWTRFLFMFITSLIFGALFWKQGKKIKDQQSLFNMLASMFSAMFFCGVFNSSTILPYVSTERTVLYRERFAGMYATWAYTLAQVTIEIPYVFIQVLAFTVITYPMIGYYWSAYKVFWYMYSMFCTLLCYNCVGMTIVSITPSYPLAAVLQSAFYNIFYLFAGFLIPRPQIPKWWVWLYYLAPTSWTLNGMLTSQYGDIHEPIQVFGQTTTVAKFLRDYFGFHHDQLPVVAVISILYPTVLACMFSYFIAKLNFQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6Q6</accession>
    <name>A0A068V6Q6_COFCA</name>
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        <recommendedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">GSCOC_T00018161001</name>
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    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
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            <taxon>Rubiaceae</taxon>
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            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP16341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00018161001"/>
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        <property type="component" value="Chromosome IV"/>
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        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41634" checksum="08B2A0AB00AD539F" modified="2014-10-01" version="1">MQFPSGLERITLRECHQLKNLWGSSNTVNLVQLKSLVVSNCSRLSSLEELGVLPMLKYLKIESCSALQSLPTLSGLNILRISSCSALSCLPMDKLLLPQLRNLGIRHCQKLNLPREIVIEDTSTSIESLEIVGCPCLNLRTMLGSVYSFASLRFLDIRDCDYDLDQLPTPSLKCLSLCRCKNVSYLPSGLGRLRSLLLYSCSSPLLFPQGDFPPTLKFLDIEAGENLQLKPLSEWGLNRLTFLERFYIRGGYPELESFSGSGDDGLALLPPTLRSVAIGDLPNLKSLSAFLRGLTALRYLHIFECPKLGSLPKESLRNPLQTLVINKCPLLQKRCLMDRGDYWPMIEDIPCVEIRSDGIRSGSMHFFSYHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6Z3</accession>
    <name>A0A068V6Z3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00018098001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium sensor.</text>
    </comment>
    <dbReference type="EMBL" id="HG739204">
        <property type="protein sequence ID" value="CDP16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6Z3"/>
    <dbReference type="FunCoup" id="A0A068V6Z3">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6Z3"/>
    <dbReference type="Gramene" id="CDP16307">
        <property type="protein sequence ID" value="CDP16307"/>
        <property type="gene ID" value="GSCOC_T00018098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6Z3"/>
    <dbReference type="OMA" id="MGKIRMP"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6Z3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000089">
        <property type="entry name" value="calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="189" mass="20971" checksum="CCA9D59A6A6B1AFF" modified="2014-10-01" version="1">MGLKSLFNRKKKRLQQPPSAANPSPMQSRSSSVQSRARIEEELEQVFKKFDVNGDGKISASELGQIMGSLGYPTTDEELHKLMNEADSDGDGFIDLQEFIELNTKDIDSDEVMENLKDAFSVFDIDKNGSISADELQNVLKSLGEECSLAECRKMICGVDADGDGMICFEEFKVMMMMGSRFDSSEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8T9</accession>
    <name>A0A068V8T9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00004800001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739225">
        <property type="protein sequence ID" value="CDP16972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8T9"/>
    <dbReference type="STRING" id="49390.A0A068V8T9"/>
    <dbReference type="Gramene" id="CDP16972">
        <property type="protein sequence ID" value="CDP16972"/>
        <property type="gene ID" value="GSCOC_T00004800001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8T9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="67" mass="7851" checksum="E848EE1F7A9C1682" modified="2014-10-01" version="1">MDVVVKVFCVHTEPNFSLPWQRKRQYSSSSGGSKGEGRGREGVRDRDRKKKGSGGQNSDRRRKRWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9Y5</accession>
    <name>A0A068V9Y5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00004085001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="HG739238">
        <property type="protein sequence ID" value="CDP17329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9Y5"/>
    <dbReference type="FunCoup" id="A0A068V9Y5">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9Y5"/>
    <dbReference type="Gramene" id="CDP17329">
        <property type="protein sequence ID" value="CDP17329"/>
        <property type="gene ID" value="GSCOC_T00004085001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9Y5"/>
    <dbReference type="OMA" id="HPMYARQ"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9Y5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00913">
        <property type="entry name" value="PCD_DCoH_subfamily_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP17329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="165" mass="18959" checksum="76DEAE2C7ADAF86F" modified="2014-10-01" version="1">MLRTPVQFQSRLLSLSMAHYYLLEIYFRHRVEVCPKASPDPMDDLTTKKCVSCNAKDMRPMTVEAAHSLIPQVQGWNLVTEDGMMKLQRTWKVKTFMKGMEFFKLVADVAEAEGHHPDLHLVAWNNVKIEIWTHAVGGLTENDFILAAKINRLDLHQLLSRKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA95</accession>
    <name>A0A068VA95_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013231001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739256">
        <property type="protein sequence ID" value="CDP17685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA95"/>
    <dbReference type="Gramene" id="CDP17685">
        <property type="protein sequence ID" value="CDP17685"/>
        <property type="gene ID" value="GSCOC_T00013231001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA95"/>
    <dbReference type="OrthoDB" id="1740548at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA95"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="47" mass="5505" checksum="AA16C3D3CD5D1FCB" modified="2014-10-01" version="1">MEWEAEQKELKEAGVELLPDERVGLRIHGWEIESSKASILKSLRRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAM6</accession>
    <name>A0A068VAM6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00005144001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739253">
        <property type="protein sequence ID" value="CDP17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAM6"/>
    <dbReference type="STRING" id="49390.A0A068VAM6"/>
    <dbReference type="Gramene" id="CDP17629">
        <property type="protein sequence ID" value="CDP17629"/>
        <property type="gene ID" value="GSCOC_T00005144001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAM6"/>
    <dbReference type="PhylomeDB" id="A0A068VAM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF66">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="539" mass="59182" checksum="E0AAE23D1EE6BC0D" modified="2014-10-01" version="1">MLEEVYFTLNSLTGKKVVRNIQFLSVELYNILVFVHGLTSRIPNEIDNLLKLESLGLVENSLSGSIPVGIFNISTLRMLDLFGNHLSGVLPSNMCHGLHNLEEIHLGWNNFSGAIPASISNCSKLIEINLDDNKFSGPIPNSIGNLRRLEFLSLSANNLTNNLLNGVLPRSIGNVSISVELLDVGNCVLRGNIPDSIGNLSNLAYLFLDDNSLTGSISSTIWGLQNLRELGLTNISLTGPLPRGLCGLLSLEYLGLSQNQISGSIPGCFSNLTSLRFLDIAFNRLTSTLPMSLWDLKGLIHLNLSSNLLRGPLAPEMGELKNLTKLDLSNNQFSGKIPSTIWKEKLHHGLVSWIKLQYLSVRTPPLFNLSKLEILALSYNSISGKIPKEILNLSKLKYLGTPFNHLSSSMPSTVSNLEFINPLGNRLSGNLPVCRSPTSLIQLHLSYNQLNSQILSDLSQQSFNLKLLSIKSSNIMGSIPETMCYNLPKLEELYTGNNQLFGQIKANLCRCSSLRILLLEDNNLGGSVPRELGNLTVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB72</accession>
    <name>A0A068VB72_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00003931001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP17804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068VB72"/>
    <dbReference type="Gramene" id="CDP17804">
        <property type="protein sequence ID" value="CDP17804"/>
        <property type="gene ID" value="GSCOC_T00003931001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB72"/>
    <dbReference type="PhylomeDB" id="A0A068VB72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 76, SUBFAMILY C, POLYPEPTIDE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950:SF4">
        <property type="entry name" value="GERANIOL 8-HYDROXYLASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="155" mass="17699" checksum="9603BCE6855E072A" modified="2014-10-01" version="1">MIGAPNVVDFFPVLKVIDVSQPNEADWHSKDMKYLFLGLFVVGTDTIAELLRNLEMMRKATSDIREVIGLGKFVQESDISRVPYFSLHSVPREEFAWNCHWLIEWCISCWLLCFITLIGSLKTGINPENMDMCERVELIVQKALPLKAIPVGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBR9</accession>
    <name>A0A068VBR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005046001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBR9"/>
    <dbReference type="Gramene" id="CDP17123">
        <property type="protein sequence ID" value="CDP17123"/>
        <property type="gene ID" value="GSCOC_T00005046001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBR9"/>
    <dbReference type="OMA" id="DKIMFIA"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43619">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE YKTD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43619:SF2">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP17123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35747" checksum="88871179F12A1587" modified="2014-10-01" version="1">MKILVSPTPPAPAIANTRGSLSHAAAIRKRNLTPRSKLNHQNDSLYQAAIERASLPVLASADPLFVDPYAGCLVPTNKFIEVDVTPRLPLYCLATKFIDDKLLNALGDDDDLRQVVLFTDGMDTRPYRLNWPRSTLVFDISPQRVFGETTLKLKEVGARIGRSCMFIHIPCESANIEEMMRNRGFKGARPSIWVFQGLPLVNLARFKEILSVISNLATKGSVLLGELPSWLSAVDAGIKSTKTQWMDNLFMSNGLRVNIIGYENVARDFEKELEKGDDNHILFTAEQLRFSDEQMETWSREFQRIEEEADEEGFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCU8</accession>
    <name>A0A068VCU8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008397001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
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        <lineage>
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                <person name="Pietrella M."/>
                <person name="Zheng C."/>
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                <person name="Anthony F."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00008397001"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058939">
        <property type="entry name" value="Mtase_EDM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235:SF13">
        <property type="entry name" value="EDM2-LIKE PROTEIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26055">
        <property type="entry name" value="Mtase_EDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658502" evidence="1">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="305" mass="35392" checksum="D5726DD58BF6C837" modified="2014-10-01" version="1">MCLCIHESTPHFLHLRLFLHFNIFLQLAVVDRLRWYVEDGDTIVDFCCGSNDFSCLMKEALDKLGRKCSFKNYDIIQPKNAFSFEKRDWMSICQDELPAGSNLIMGLNPPFGVHASLANMFISKALTFSPKLMILIVPKETKRLDRGKLPYDLIWEDDELLSGKSFYLPGSVDVLAQQMEQWNAETPPLYLWSRPDWTVKHKAIAREHGHISMELDVGRIREINVEPSVSNYLMEDKHDCYHDFSSVMKGYSDITSMLDDLPDEFDGTQPNQLRDTRAEMQFDRQLKNRCPDAEDHSVDMDWEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDX3</accession>
    <name>A0A068VDX3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00011892001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit (LSU).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739271">
        <property type="protein sequence ID" value="CDP17898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDX3"/>
    <dbReference type="FunCoup" id="A0A068VDX3">
        <property type="interactions" value="2721"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDX3"/>
    <dbReference type="Gramene" id="CDP17898">
        <property type="protein sequence ID" value="CDP17898"/>
        <property type="gene ID" value="GSCOC_T00011892001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDX3"/>
    <dbReference type="OMA" id="MAHGPRY"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDX3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009955">
        <property type="term" value="P:adaxial/abaxial pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009965">
        <property type="term" value="P:leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="8">
        <location>
            <begin position="289"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP17898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="359" mass="40837" checksum="8CF1737F361D925D" modified="2014-10-01" version="1">MNSLFYLIKKPITPSLFLLRLFLTKRPLSPPIAPSTTHPQNPLTPRPPAPTAVAMAFVKAQKTKAYFKRYQVPFKRRREGKTDYRARVRLINQDKNKYNTPKYRFVVRFTKKDIIAQIVSASIAGDLVLAAAYSHELPHFGLEVGLTNYAAAYATGLLLARRVLKKLEMDEEYEGNVEATGEDYSVEPGDSRRPFRALLDVGLIRTTTGNRVFGALKGALDGGLDIPHSEKRFAGFDKETKQLDPEVHRKYIFGGHVAAYMRTLAEDEPERYQSHFSEYHKRGLEADNLEELYKKVHAAIRADPTPKKSEKAPPKEHKRYNLKKLTYEERKASLIERLNALNSAAGNDDDDDDEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF09</accession>
    <name>A0A068VF09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00011993001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF09"/>
    <dbReference type="FunCoup" id="A0A068VF09">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18268">
        <property type="protein sequence ID" value="CDP18268"/>
        <property type="gene ID" value="GSCOC_T00011993001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF09"/>
    <dbReference type="OMA" id="TCSLIGW"/>
    <dbReference type="OrthoDB" id="506011at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="251" mass="27915" checksum="8F35D066B8A5E96C" modified="2014-10-01" version="1">MEDYIVGLVVAGVFFWTILFLLTKGIFQERSFDFSLRVVSSIHAIIAVTLASLSIQDWSCPIFPLASKSSPMQIQTLAISGAYLIFDLACCQFSDNINLDTIFHHLVCILGIWAGLASERYGSEMVAALWLGEISGPFLHLRDLLKEMGYRDTDLNLAIDILFAIIFTAARMIVGPYLTYVFLFSDSPLLMKAPALGLQLVSAFWAYKIVRMVIYKLSSKGMPSSQPAVDGEASYKCCVPPLSLRRLPQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFT4</accession>
    <name>A0A068VFT4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD finger protein ING</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00012177001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739338">
        <property type="protein sequence ID" value="CDP18553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFT4"/>
    <dbReference type="FunCoup" id="A0A068VFT4">
        <property type="interactions" value="1782"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFT4"/>
    <dbReference type="Gramene" id="CDP18553">
        <property type="protein sequence ID" value="CDP18553"/>
        <property type="gene ID" value="GSCOC_T00012177001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFT4"/>
    <dbReference type="OMA" id="PIYITPQ"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFT4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17015">
        <property type="entry name" value="ING_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000177">
        <property type="entry name" value="PHD finger protein ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP18553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="259" mass="29810" checksum="8BB7C43B9C5EB3AE" modified="2014-10-01" version="1">MAIARTGVFVDDYLEYANTLPAELQRLLNTIRELDERSQAMINQASQQTKLCLGMASHRNHDSYRDQDNEEAFEKMKKEIEATQENTLSLCTEKVLLARQAHDLIDSHIKRLDEDLNNFAEDLKQEGKLAADEPAILPTLPLVPKNEKRKPIYGTPQSKKLDYRDRDWDRERDRDFELMPPPGSGNKKDFTAPVDVDQPIDPNEPTYCVCNQVSFGDMIACDNENCQGGEWFHYSCVGLTPETRFRGKWYCPTCRQLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG55</accession>
    <name>A0A068VG55_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00011631001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739779">
        <property type="protein sequence ID" value="CDP19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG55"/>
    <dbReference type="STRING" id="49390.A0A068VG55"/>
    <dbReference type="Gramene" id="CDP19800">
        <property type="protein sequence ID" value="CDP19800"/>
        <property type="gene ID" value="GSCOC_T00011631001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG55"/>
    <dbReference type="OMA" id="GANICHE"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VG55"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF13">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 81, SUBFAMILY K, POLYPEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="498" mass="56103" checksum="9553CEDCC3A14479" modified="2014-10-01" version="1">MELLYTILGLFIFLIAVKYQYLRKKNRKLRPPSPPALPILGHLHLVKTAPHLALQKLSIKYGPLISLHFGIRPFLVVSSPSLAEECLTKTNDIIFANRPESVSKIHFIIKKLFSSNSDEKTWKVKDMSSLFRELLFNVIMKIAAGKRWPSDQPGDIFSPRALTDLCDYIPILRWVGYGGLEKGVISLHQKRDEFLQGLIDQTRKEVAEDGSCSTERRKTIIQKLLSLQEAEPEYYTDEIVKGIIQAPDLVVSGEMVYATNFSVGLMLSAGTHTTSQTMEWALSSLLNHPNVLQKARDELEKMQPGHLLNDSDLSKLPYLRCIINETLRLFPAAPTLVPHFSSEDCTIGRYEVPKGTTLLVNVWAIHRDPNVWEEPNKYKPERFEGMDEGGWNEGFKFLPFGKGRRICPGAAMAIRLAGLTLGTLIQCFEWQRVGPEMKTGIHGDPNVWEEANKFKPERFEVIYDEGSNFLPFGKGKRACPGAALAMKLVALSLGTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH18</accession>
    <name>A0A068VH18_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DH200=94 genomic scaffold, scaffold_763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00003238001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739847">
        <property type="protein sequence ID" value="CDP19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH18"/>
    <dbReference type="STRING" id="49390.A0A068VH18"/>
    <dbReference type="Gramene" id="CDP19887">
        <property type="protein sequence ID" value="CDP19887"/>
        <property type="gene ID" value="GSCOC_T00003238001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH18"/>
    <dbReference type="OMA" id="LYFHPAD"/>
    <dbReference type="OrthoDB" id="1720310at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH18"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000003">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000007">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000252">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000645">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590">
        <property type="entry name" value="OS03G0124300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590:SF5">
        <property type="entry name" value="OS04G0586500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655938" evidence="15">
        <location>
            <begin position="22"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="536"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="825" mass="91350" checksum="02B994B5CF8DAE65" modified="2014-10-01" version="1">MFTLLVYLSFLFNLLFIITSSDTPPYSPTDYILINCGSSSNATSADGRNWYGDAGSKFSPNDMATISSAVTATEQDSSVSGAPYLTARIIRSNFSYTFPVSPGKKFVRLYFYPASYSSDFNATESFFAVMANNYTLLSNFSAFLTVSFGGSSSASLVKEFIINVQAMNQFLNVTFSPSPKSYAFINGIEVVSTPDGLYMGNHDMSSNPLKNVNDPNIQFELDQNDTAFEALYRLNVGGKDVSALADSGMFRGWVPDDNFIWGADKGNPLSNNQIAVKYTPQTPNYTAPAIVYTTARAMGELSTRFNLSWMFYVDSGFDYLLRLHFCEITPDLISQENERVFRIFISNKTAEREIDIITWTGGPGIPVFRDYVVFVPHPPDGRPSKQGLFLALYPNLDFKTKYADAILNGLELFKLSNSGSLAGTNPDQAADPNSPMPNSKSPKKGRGVKSPVLFPIVGGVVGGSALVFIIGFLISRRLRRRVKDFDQKSASKSSGVQLSTRSRSSKTTSASRSSSLPLDLCRRFSLEEIIFATANFDAKFVIGTGGFGNVYKGYIDNSLITVAIKRLNPSSSQGVREFRTEIEMLSNLRHLHLVSLIGYCDEKGEMILVYDYMANGTLRDHLYKTDNPPLPWKQRLQICIGAARGLHYLHTGAKHNIIHRDVKSTNILLDEKWVAKVSDFGLSKLGPSGGIHSHVSTQVRGSFGYVDPEYYKRQQLTEKSDVYSFGVVLLEVLCGRGAIIRNLPKEQVNLAGWGKRNYAKGIIHQTVDPHMKGEIAPECLRSFAETAINCLKDQGIERPGMNDVVWSLEFALQLQEAAENERLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH32</accession>
    <name>A0A068VH32_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH200=94 genomic scaffold, scaffold_835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00012538001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739919">
        <property type="protein sequence ID" value="CDP20021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH32"/>
    <dbReference type="FunCoup" id="A0A068VH32">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VH32"/>
    <dbReference type="Gramene" id="CDP20021">
        <property type="protein sequence ID" value="CDP20021"/>
        <property type="gene ID" value="GSCOC_T00012538001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH32"/>
    <dbReference type="OMA" id="REYYPYS"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH32"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF18">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 16-3, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="215" mass="23048" checksum="1F92A4F4F4088A16" modified="2014-10-01" version="1">MFSKISKLTRLWAQNVCQSHSLVSTPLPVSFALSPLFYCSLSEIATADQCQVCLAKVMDPAELRYLEEEDTPLMKTIKGATSGLVAGTIWGTIVATWQDVPRVERRVALPGLIRTLKMMGNHGITFAAIGGVYIGVEQLLQNYRMKRDFINGAVGGFAAGATVVGYKGKSIATALSAGAALAATSAFIDVGGQTTRIDNGKEYYPYTTKKRASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHR9</accession>
    <name>A0A068VHR9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00009227001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739455">
        <property type="protein sequence ID" value="CDP19183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHR9"/>
    <dbReference type="STRING" id="49390.A0A068VHR9"/>
    <dbReference type="Gramene" id="CDP19183">
        <property type="protein sequence ID" value="CDP19183"/>
        <property type="gene ID" value="GSCOC_T00009227001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHR9"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHR9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="8064" checksum="05A3EA188CDB6995" modified="2014-10-01" version="1">MLDNICGICCIACYFSLAKCEKFKPFVFNFQEIQIDELITHDLPFEDVNKAFDLMREGNCLRCVIHMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK33</accession>
    <name>A0A068VK33_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00013427001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739924">
        <property type="protein sequence ID" value="CDP20033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK33"/>
    <dbReference type="STRING" id="49390.A0A068VK33"/>
    <dbReference type="Gramene" id="CDP20033">
        <property type="protein sequence ID" value="CDP20033"/>
        <property type="gene ID" value="GSCOC_T00013427001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK33"/>
    <dbReference type="OMA" id="IKNHICD"/>
    <dbReference type="OrthoDB" id="939809at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="96"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="112" mass="12794" checksum="D2138274F163AE33" modified="2014-10-01" version="1">MDPRKRITAAEALEHQWLKEGGEASDTPIDSVVQIRMKQFRAMNKLEKLALKVIAENLSEEEIKGLRQMFNNMDMDRSGTITYEELKTGLSRLGSKLLEEEIQELMEAVSNP</sequence>
</entry>
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    <accession>A0A068VK70</accession>
    <name>A0A068VK70_COFCA</name>
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        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2479</fullName>
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        <lineage>
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            <taxon>asterids</taxon>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <location>
            <begin position="126"/>
            <end position="232"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP21101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="233" mass="27436" checksum="847EA5436B383EB0" modified="2014-10-01" version="1">MLSRETSIQLTLQFLYSYNKLHFIILNTIKQSVKMRNNILHIKFFLHSTMLHKHTLFKLDLNMSRAWLTRATNWTKFSATALQLIDSGHLQQRKSLMAPCHRMRLVVVAAHIQKHKHWYLSYCIIIDIKYQRLDKLQQILIQTDNIQVTLYFCNHVSDVKTSEILTSTTLMHMSPDYLSICQLLMFLDRPQDIAAAFEKLLRAKSKNDGLLGFQIAFDLVENEHQAYLLKMRD</sequence>
</entry>
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    <accession>A0A068VKB2</accession>
    <name>A0A068VKB2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2816</fullName>
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    <gene>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741900">
        <property type="protein sequence ID" value="CDP21215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00008669001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKB2"/>
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    <dbReference type="OrthoDB" id="1516808at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKB2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33494:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="118" mass="12906" checksum="0AFD4A72A0FB16BD" modified="2014-10-01" version="1">MRLSQANSPKGASSSKKELKGAAASGSSEKLKASNFPATILRIGTWEYKSRYEGDLVAKCYFAKHKLVREVLDGGLKNKIEIQWSDIMALKANYPDDGPGTLDVVLAGQPLFFRETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLB4</accession>
    <name>A0A068VLB4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_5034</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00008842001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG744118">
        <property type="protein sequence ID" value="CDP21580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLB4"/>
    <dbReference type="STRING" id="49390.A0A068VLB4"/>
    <dbReference type="Gramene" id="CDP21580">
        <property type="protein sequence ID" value="CDP21580"/>
        <property type="gene ID" value="GSCOC_T00008842001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLB4"/>
    <dbReference type="OMA" id="NIANGNC"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000061">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000076">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="3">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="3">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP21580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="319" mass="34922" checksum="82AE174295CAFC45" modified="2014-10-01" version="1">MTPVGGKLSWQSYTDETPSADDSDVLVMNGLWEQLNVTRDSSDYLWYLTDVNIASNEGFLKSGQDPLFTVMSAGHALHVFINGQLSGTVYGSLDNPKLTYSSNVKLRAGVNKISLLSVAVGLANVGVHFETWNTGVLGPITLKGLNEGTRDLTKQRWTYKVGLKGEAQSLHTVTGSASVEWAEGSLLANKQPLTWYKTTFDVPPGDDPIALDMGSMGKGEVWVNGQSIGRHWPANIANGNCGGCNYAGTFSEKKCQMHCGKPSQRWYHIPRSWLQPSGNLLVVFEEWGGDSTWLYLVKRTSPPPPIWFSDKTATSAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMP7</accession>
    <name>A0A068VMP7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_2117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00005959001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG741201">
        <property type="protein sequence ID" value="CDP20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMP7"/>
    <dbReference type="Gramene" id="CDP20953">
        <property type="protein sequence ID" value="CDP20953"/>
        <property type="gene ID" value="GSCOC_T00005959001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMP7"/>
    <dbReference type="OMA" id="WYLEMSA"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052592">
        <property type="entry name" value="LRR-RLK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054:SF94">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN FASCIATED EAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP20953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="531" mass="59188" checksum="20B4DB3331120756" modified="2014-10-01" version="1">MNIKWPKFPFFGSILYNITTYLDFSQKVTHNHFSELESYIAVDKQFGWPNTRKIFQTIPHFKLFTYRTVNSIDKYQRDICYSSKIKVRFFTIPFSPSTRVVALNISNMGFEGTIPLQLGNLSFLVTLDMSNNSFHGYLPEGMSHWRRLSLMALSNNNLAGEIPSWLGVLDRLQYLSLRNNSFVGHLPTNICDNLPNLKELDMSLNQLSGEILSGLANHSRLESLSLSFNWFNGSMPKELGSLKMLEVLDLGYNLVEGPIPNEMFNISTLRVFDLSDNHLSGILPSNMCHGLHNLEDISLAVNDFSGVIPASISNCSKLAIISLGDNKFSGRIPNSIGNLRHLEFMIIWVASNPLNGILPRSIGNLSISVEWLDLANCGLKGNIPNSIGNLSNLRYLNPRSNSLTGSIPTTIWGLQKLIGLGLHNNSLSGSLSGCFNNLTSLRYLDIAFNRLTSTLPMSLWDHKDLVVVNLSSNFLRGPLAPEMGELKFLTTLDLSNNQFSGKISSTIWSLESLDYLSLANNSLQGSIPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMU2</accession>
    <name>A0A068VMU2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_9048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013495001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748132">
        <property type="protein sequence ID" value="CDP22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMU2"/>
    <dbReference type="Gramene" id="CDP22011">
        <property type="protein sequence ID" value="CDP22011"/>
        <property type="gene ID" value="GSCOC_T00013495001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMU2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="112" mass="12703" checksum="F8887E2C0421DB6A" modified="2014-10-01" version="1">MSEHKPLNFRGSALADLRAFPATVRQEVGYQLDKVQRGLEPKDWKPMATVGQGVREIRIRDANGAFRVIYVAKLAEAVYVLHCFQKKTQKTSKADLDLAEARYRALLSEVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQU9</accession>
    <name>A0A068VQU9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_10073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012633001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG749157">
        <property type="protein sequence ID" value="CDP22093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQU9"/>
    <dbReference type="FunCoup" id="A0A068VQU9">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VQU9"/>
    <dbReference type="Gramene" id="CDP22093">
        <property type="protein sequence ID" value="CDP22093"/>
        <property type="gene ID" value="GSCOC_T00012633001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQU9"/>
    <dbReference type="OMA" id="MWAGNRV"/>
    <dbReference type="OrthoDB" id="1667873at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQU9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47000">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47000:SF1">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP22093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="163" mass="18009" checksum="D613D55B4222EB7B" modified="2014-10-01" version="1">MIVVDSSPEAKNAIQWALTHTVQSQDLVILLYVTKPSNPGEEAIKEVAPRVSQFLSCMKILCQQKRPEVQIEVAVAEGKEKGPAIVEEAKKQGVALLVLGQKKRSTTWRLLMMWAGNKVAAGGVVEYCIQNATCMALAVRKKSKKLGGYLITTKRQKDFWLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLD5</accession>
    <name>A0A068TLD5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013820001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLD5"/>
    <dbReference type="FunCoup" id="A0A068TLD5">
        <property type="interactions" value="2623"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLD5"/>
    <dbReference type="Gramene" id="CDO96714">
        <property type="protein sequence ID" value="CDO96714"/>
        <property type="gene ID" value="GSCOC_T00013820001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLD5"/>
    <dbReference type="OMA" id="IDMESPR"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="72"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO96714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="160" mass="18769" checksum="7BF5E583670DE5E4" modified="2014-10-01" version="1">MGRGKFKGKPTGRRQFSTPEEMIAGTSASRPRTFRQEEAEVEEDVRSEEESEEESEDEEKRKGTQGVIQIENPNLAKPKNVKARDIDMEKTTELSRREREEIERQKAHERYMKLQEQGKTEQARKDLERLALIRQQRAEAAKKREEEKAAKEQKKVEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLS8</accession>
    <name>A0A068TLS8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00014541001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLS8"/>
    <dbReference type="FunCoup" id="A0A068TLS8">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLS8"/>
    <dbReference type="Gramene" id="CDO97265">
        <property type="protein sequence ID" value="CDO97265"/>
        <property type="gene ID" value="GSCOC_T00014541001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLS8"/>
    <dbReference type="OMA" id="NRCQHPS"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLS8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="163" mass="18230" checksum="D60A801FCCE7BACF" modified="2014-10-01" version="1">MSSSKEAASSSHIVEEDDDELLLYGSGSGWVEALTHCDHLDTLSSDLTHIPPPDTPCYRCEHPQENWLCLSCEDVLCSRFVNKHMLEHYRQQNNHCLALSYSDLSVWCFSCDAYLDAQVILPLRPVYETAYILKFGEAPPFRALVDLHLADHKAEGSSSGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN05</accession>
    <name>A0A068TN05_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein WUSCHEL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00013826001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WUS homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN05"/>
    <dbReference type="FunCoup" id="A0A068TN05">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN05"/>
    <dbReference type="Gramene" id="CDO96718">
        <property type="protein sequence ID" value="CDO96718"/>
        <property type="gene ID" value="GSCOC_T00013826001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN05"/>
    <dbReference type="OMA" id="RVTVFIN"/>
    <dbReference type="OrthoDB" id="1935198at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN05"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000118">
        <property type="entry name" value="WUSCHEL-related homeobox 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044557">
        <property type="entry name" value="WOX8/9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47288">
        <property type="entry name" value="WUSCHEL-RELATED HOMEOBOX 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47288:SF1">
        <property type="entry name" value="WUSCHEL-RELATED HOMEOBOX 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0287">Flowering</keyword>
    <keyword evidence="7 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO96718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="406" mass="44999" checksum="6E1FA8E137E69E4A" modified="2014-10-01" version="1">MASSNRHWPSMFKSKPCNSQHQWQHEINSSLISNGCQRAPSCASSGSEERSPEPKPRWNPRPEQIRILEAIFNSGMVNPPRDEIRKIRAQLQEYGQVGDANVFYWFQNRKSRSKHKQRHFQSTTKSQPPQIPHITSTPPATKTTSLSSSSSSSEKSSQNSADKTLSLGPKNLFDTSSSPTASVNQHFFQSHSAEFLPAPFFFPVQQPPSAAESTPPAAFSQGFCFSDAPSLSHLADNTIQNSSSILLSDLLLMNHLPTKKVQDEKIKLQQQLNYTALTTPPITTSQSIFSPTRVAAVSSIDHVHGVGETGSADPTKSTVFINDVAFEVTSAFFNVREAFGDDAVLVHSSGQPVMTNEWGVTLQPLQHGAFYYLIRTSTSSSHDTTIDLVLNLRVVCFHFRSLRNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNJ3</accession>
    <name>A0A068TNJ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cx9C motif-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00014895001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNJ3"/>
    <dbReference type="FunCoup" id="A0A068TNJ3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNJ3"/>
    <dbReference type="Gramene" id="CDO97524">
        <property type="protein sequence ID" value="CDO97524"/>
        <property type="gene ID" value="GSCOC_T00014895001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNJ3"/>
    <dbReference type="OMA" id="CNYNSTH"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNJ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO97524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7115" checksum="40E0515E1FB3B5A6" modified="2014-10-01" version="1">MPEPSKEPCKKQACDIQACLTKSNFNPQRCVRVIELLQACCEECKYKSTHCASVSGLLKQIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNL7</accession>
    <name>A0A068TNL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00014150001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068TNL7">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNL7"/>
    <dbReference type="Gramene" id="CDO96953">
        <property type="protein sequence ID" value="CDO96953"/>
        <property type="gene ID" value="GSCOC_T00014150001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNL7"/>
    <dbReference type="OMA" id="CLDYRCW"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1779"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO96953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2014" mass="225456" checksum="B72C87EB3F09C9B7" modified="2014-10-01" version="1">MHAHQKEEEEEEHQGPSKSSRVDSSQGTYEKQKTEAEDGKLLFNLEEVSPWRNLQLILLLQNKRIDLPTKLEVACKYVLLRTSIREDGDDSLEILDAVSMSRVVVFVSNWIESVLISSVKKTPDKGSEGHPETVGFCLDYRCWVILKFCLEESLKVNVSLNYSRDFLRVIDCISRDALACFSLELKDSKESALSSEGNELQETVLSCISLIFSSHNGVANANLDLWIMVTDTVLEIVRKVFSNKVADSKAGIFILQFSCYLLEPFAKFLRVHPARKNGFHDFIDRLLEPLMHLLDELRLSTCKDLGWSKNLLKLVEEISSQGLFHAAHIDGFLSLQSTGKYKKSDDGKSKERIFFIKSYHRKLFDKLEKIIACKNSLPLGGVGALFHLFVVCATKQKGVSSVNKVSRQLEDSAGHISERFSGSSNVALQTQNCSGSVSAVTRKSLFDFFVQIMESFLSHITMHLQAEWNVGTPLSDVLCVLISANKLLASFKQENIYTRLEDISEGACMNFLRFIYETIMLLSVKIKHLMSSFGSNVRNQEVLILMAKEIVVAVHLLVEIEYEVVGDDLENLWGMMFTFASSSQSMVDVPDKHLLISEIHILGCALINLYSELRQVNTSVFALCKAARHLESAHKDGEACTSESYCSCSMSLSTFLCSLEFRLSIYNGFKSIPEGQVSGCIRLLTAEISESLKWLNAQLQLGPADDLSKPGCTDGGFSWFDLKAELLGRFLSEIYTLILDSMTVTSGNCNAVGSSIKDLMELMCHSSNSQDLLKPDIMDKFFSLVSGQSSSWGVGLENDSLSCWLLVFFFRLYLSCRSLYRRVISHVPPHTSKKMSETMGDPYAAYSGKDWLDGIVQNAEGYFSWIIQPSANLLTIINNVSRMYFQDTLAGCPPLVYVLNAMTIQRLVDLNRMTKSFEYLLARNDKLIAAEMIDDTGVSYKRGKKWRKCLLSMKQEAAGLTKFMMLCFSSLFKDQLTISYDSGLSKCLSIQNLQKDNAWDLNVGALDQKTLPAAMWLIACQHIDIWCRHASKKDLKQFLTHLINCSLLIGSGGNDKFRSHCINKVGHLRNVTTQQISLELLNDTGLYEQKFFRRHIASTFCQILEASLSSISVDFGEGYLSSQHDWSEIIRALRNPSNIIHVKKSAKNAEICRIEDVAPSSNTEYALCNSLLNFLSWMPKEILGPKSFQSFANCILKLEQVAVGSLLGWYNTLLAGGHDEFFQLFLSCRRTLKSLLMASCEENMDYNHSSLISLLLEGSSPVLWLLESLLAVVGFQNASSEAVPSQLKDLLFSLMDHTSYMFLTVGKNRLQISLLFSGMDYNGQDNFAVGSQDTDLAEDEPHLDFCRDNDPCKSLALVANVLSECMQNSLACFSQAYASENLGVLPEFQELKKLSPVISCIQGFLWGLASGLGTRDAENCKMRIRLSKCELEPLYKLNIFINTCAEYVSYFLQLFLLEDDSLAQNLAIAQKLDQPELDHPCLENEEVQLFDSRCLRKTFLHELIRGDKSEEAYFLKQLFLAAAAILRLKLELGSTALLQNIMPILLGVSEVLLLEFARDVAPPPFSFVWLNGVIKFMEELGNCFPSSSPILSRKLYGKLIDLHLRSIGKCIVLQGKIATLSSKETGSSMEKPIEWLNFSESSISHESSCLDDFIARLRTSFRVLVQKSSELHLLTAIQAIERAVVGVQDGCLTNYEIHIGSLGCGKVSSVVAAGIDCLDSLIEFVTGRKRLNVVKRHIQSLVACLFNVVLHLQGPSIFQGNVNFDEGYTGPDSGSVILMCIELLRRVTGKHALFQMDASYVGQSLNIPAALFQNLLQLQLSDSYSSTTSKTTDTCSLKITSGRILDGRYSLDLYAACCRLLSSLVKHHGSETQRCAALLEHSVSILLHCLEMVNIDPIVRGGNFAWEVQEGVKCACCLRRVYEEIRQQKDSLGRCCFQFLSCYIWVYCGFGPLKTGIRREIDEALRPGVYALIDACSADQLQHLHTVFGEGPCRSALAILQNDYKLYFQYEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNS7</accession>
    <name>A0A068TNS7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00021949001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 9">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNS7"/>
    <dbReference type="STRING" id="49390.A0A068TNS7"/>
    <dbReference type="Gramene" id="CDO97990">
        <property type="protein sequence ID" value="CDO97990"/>
        <property type="gene ID" value="GSCOC_T00021949001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNS7"/>
    <dbReference type="OMA" id="CKPLHKF"/>
    <dbReference type="OrthoDB" id="1918787at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNS7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33573:SF48">
        <property type="entry name" value="CASP-LIKE PROTEIN 3A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33573">
        <property type="entry name" value="CASP-LIKE PROTEIN 4A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="10">
        <location>
            <begin position="43"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO97990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="22408" checksum="26D12F017EB7F2CD" modified="2014-10-01" version="1">MNGAKNAGEAVNIQLPEMKVAAEMGTMSGPLVAPRPSRSVHGKMDIAHVVLRLACLLTSVTALSLMATAKQASTLSLYGFNVPVRSNWSFSDSFEYLVGVSAAVAVHSLLQLLISGSRSLRKSPAIPSRNHAWLIFAGDQVFAFAMLSAGSAASGVTNLNRTGIRHSALPNFCKPLHAFCDRVAASIAFAFLSSLFLAISTVLDVVWLSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP68</accession>
    <name>A0A068TP68_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022118001</name>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ71"/>
    <dbReference type="FunCoup" id="A0A068TQ71">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ71"/>
    <dbReference type="Gramene" id="CDO98401">
        <property type="protein sequence ID" value="CDO98401"/>
        <property type="gene ID" value="GSCOC_T00022481001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ71"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ71"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03785">
        <property type="entry name" value="GT28_MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="11">
        <location>
            <begin position="241"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO98401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="44882" checksum="E7EBDAEE3F29365C" modified="2014-10-01" version="1">MFHTLVHLQFHTLNFKTNSCLSLNQPSAKTTNASAAAAASETLKVAFAAGGTGGHISPAVAIADELKNQNPDIQILFIGTPTGMESAAVPFAGYPFVAIPAAPLARPLISVHNIFILPFLLTKSLVKSFQTLQEFSPQIVIGTGGYVSFPICLAAAMKGLKLVIQEQNSVPGIANWVLSLFAEKVFVAFNSSVDCFWQRNKCIVCGNPVRFSLSKNVVKADARKHFFPKAVEGTGKGQGKVVLVLGGSLGASAINIALLNSYFEMLNQREDLFIIWQTGVESFDEMESLVKNHPRLILKSFLHSMHLAYAAADLIISRAGAMTCSEILATGKPCILIPSPNVDEGHQLKNAFLMADLAGSTVITEDELDSTTLRTAVEEILDNESLMVEMSQRALQAAKPNASSEIAQYILSVVSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQQ1</accession>
    <name>A0A068TQQ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022429001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQQ1"/>
    <dbReference type="STRING" id="49390.A0A068TQQ1"/>
    <dbReference type="Gramene" id="CDO98362">
        <property type="protein sequence ID" value="CDO98362"/>
        <property type="gene ID" value="GSCOC_T00022429001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQQ1"/>
    <dbReference type="OMA" id="AYAVTIN"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQQ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF146">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIS8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="192" mass="21710" checksum="F10526B171943FF0" modified="2014-10-01" version="1">MTLSLSFILSTFQQARIVMLLMFRFYVKVYLPFLEDSSMLLALILSALEMFSLPRFSLKKAEWMAPEVLRNEPSDEKCDVYSFGVILWELCTMQQPWGGMNPMQVVGAVGFQHRRLDIPEDIDPAIAAIIHRCWQTDPKLRPSFAEIMAALKPLQKPVIGSQVPRPSVPPVSRVQEKGQPSGIPEYSPGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR64</accession>
    <name>A0A068TR64_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00025718001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR64"/>
    <dbReference type="Gramene" id="CDO98795">
        <property type="protein sequence ID" value="CDO98795"/>
        <property type="gene ID" value="GSCOC_T00025718001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR64"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000121">
        <property type="entry name" value="Myb transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999:SF91">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB8-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO98795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="357" mass="38732" checksum="663D1B6264D1E64E" modified="2014-10-01" version="1">MGRAPCCEKVGLRRGRWAAEEDEKLINYIKQNGEGSWRSLPKNAGLLRCGKSCRLRWINYLRADLKRGNFTREEEETIINLHRSVGNKWSLIASKLPGRTDNEVKNYWNSHLSRKIYSFRSSDGSSVTTLDMVNIPSKSKRKGGRVSRAVAKKYSMHPITKAPITTATNETSSSSKISSTSGVQEATTAAQNAQVGMVEATTHGVPESAAAAEKVSDDAAVGAVEESGKHQLQPMANNNYDYDESEGGCINSMHDIRCDGGEGCARALLVPSPEKLEGEKGVAGPNDELDDVTLLLESVLESELMDLSEISVHTGDTENESIMYPESASMNRDSDSGASNSNSDTGDGLIRALGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS54</accession>
    <name>A0A068TS54_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MPBQ/MBSQ family SAM-binding methyltransferase profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00026164001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS54"/>
    <dbReference type="FunCoup" id="A0A068TS54">
        <property type="interactions" value="1150"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TS54"/>
    <dbReference type="Gramene" id="CDO99125">
        <property type="protein sequence ID" value="CDO99125"/>
        <property type="gene ID" value="GSCOC_T00026164001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS54"/>
    <dbReference type="OMA" id="FNRFPTE"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS54"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051741">
        <property type="term" value="F:2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000095">
        <property type="entry name" value="2-methyl-6-phytyl-1,4-hydroquinone methyltransferase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044649">
        <property type="entry name" value="MPBQ/MSBQ_MT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031164">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44516:SF11">
        <property type="entry name" value="2-METHYL-6-PHYTYL-1,4-HYDROQUINONE METHYLTRANSFERASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44516">
        <property type="entry name" value="2-METHYL-6-PHYTYL-1,4-HYDROQUINONE METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51734">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="MPBQ/MBSQ family SAM-binding methyltransferase profile" evidence="4">
        <location>
            <begin position="59"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="331" mass="37622" checksum="DEB79CD83DFCDA7B" modified="2014-10-01" version="1">MASSLLSGAECKLVTGFGSELQFRPLPKKGLAYYPKRWYISTLAPKCSLSSSRPVSQPRFIQHKQEAFWFYRFLSIVYDHIINPGHWTEDMRDEALEPADLFSRHLTVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKEKEPLKDCKIIEGDAEDLPFPTDYADRYISAGSIEYWPDPQHGIREAYRVLKIGGKACIIGPVYPTFWLSRFFADVWMLFPKEEEYIEWFQKAGFKDVKLKRIGPKWYRGVRRHGLIMGCSVTGVKPMSGDSPLQLGPKVEDVKKPVNPFVFLTRFILGALAATYYVLVPIYMWIKDKIVPKGMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTF5</accession>
    <name>A0A068TTF5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-cysteine desulfhydrase</fullName>
            <ecNumber evidence="9">4.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00022781001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11268"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:35236"/>
            <dbReference type="EC" id="4.4.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.15" evidence="9"/>
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        <property type="protein sequence ID" value="CDO98623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTF5"/>
    <dbReference type="Gramene" id="CDO98623">
        <property type="protein sequence ID" value="CDO98623"/>
        <property type="gene ID" value="GSCOC_T00022781001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTF5"/>
    <dbReference type="OMA" id="ERYHAGT"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTF5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019447">
        <property type="term" value="P:D-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009693">
        <property type="term" value="P:ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990170">
        <property type="term" value="P:stress response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000042">
        <property type="entry name" value="Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000037">
        <property type="entry name" value="Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005966">
        <property type="entry name" value="D-Cys_desShydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01275">
        <property type="entry name" value="ACC_deam_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="41"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO98623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="385" mass="42370" checksum="F0C3F3684C399D03" modified="2014-10-01" version="1">METDNKAHQQSGFNFGFLTKKPYDPPSWASHLSPIPSHVYSLGHFPTPIHKWSLPNLPKDTEVWLKRDDLSGMQLSGNKVRKLEFLLADAVAKGADCVITIGGIQSNHCRATAVAAKYLNLDCFVILRTSKVLVDKDPGLTGNLLVERLVGAHIDLVTKEEYAKVGSVELTKILKEKLLREGRRPYVIPVGGSNSLGTWGYIEAIREIEHQLQHSKSGFDDIVVACGSGGTVAGLSIGSWLSNLKAKVHAFCVCDDPEYFYDYVQGLLDGLDAGVSSHDIVDIQNAKGLGYAMSTSEELKFVKEIAETTGVILDPVYSGKAAYHMMKDMAENPAMWEGRKILFIHTGGLLGLYDKVEQIAPLVGKWRQMDIHESVPRKEGTGKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTR0</accession>
    <name>A0A068TTR0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026490001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTR0"/>
    <dbReference type="Gramene" id="CDO99354">
        <property type="protein sequence ID" value="CDO99354"/>
        <property type="gene ID" value="GSCOC_T00026490001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTR0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="91" mass="10357" checksum="44E60716C61648A2" modified="2014-10-01" version="1">MKVESQPRKAPETIHPVSESTQNQHLLKTLLQRTICSLKGSIFIGFINRVLFSSCYQRVYEVGFRPRPCPKLADRILGIGILLLTRLDFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUM8</accession>
    <name>A0A068TUM8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00029380001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUM8"/>
    <dbReference type="FunCoup" id="A0A068TUM8">
        <property type="interactions" value="1993"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUM8"/>
    <dbReference type="Gramene" id="CDO99707">
        <property type="protein sequence ID" value="CDO99707"/>
        <property type="gene ID" value="GSCOC_T00029380001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUM8"/>
    <dbReference type="OMA" id="GHHHTKM"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUM8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000028">
        <property type="entry name" value="Tyrosyl-DNA phosphodiesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000031">
        <property type="entry name" value="Tyrosyl-DNA phosphodiesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
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            <position position="69"/>
        </location>
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            <position position="321"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO99707.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50173" checksum="730455F63781C53E" modified="2014-10-01" version="1">MLLRTVKVSKSIIFGFISSNQACPLLKKVPNVLVIHGESDGILEYMKRKKPASWILHKPPLPISFGTHHSKAMLLVYPQGVRVVVHTANLIHVDWNNKSQGLWMQDFPWKDNNGASKGCGFESDLIDYLTMLKWPEFNVDLPALGSYSIKPSFFKKFDYTSAVVRLIASVPGYHSGSNLKKWGHMKLRTVLQECTFSEEFQKSPLVYQFSSLGSLDEKWMLEFASSMSAGVTRDKKPLGVGEPLIIWPTVEDVRNSLEGYAAGNAIPSPLKNVEKAFLKKYWAKWKANHSGRCRAMPHIKTFTRYNGQNLAWFLLTSANLSKAAWGALQKGNSQLMIRSYELGVLFLPSSIKPGCGFSCTDIAKSSDDNGGLQKSSETKRMKLVTLNWQGDQTEVIQLPVPYELPPKPYSREDVPWSWDRHYAEKDVYGQVWPRQVKLYACQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUS9</accession>
    <name>A0A068TUS9_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">GSCOC_T00029837001</name>
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    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>lamiids</taxon>
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            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF69">
        <property type="entry name" value="NUCLEOTIDE-BINDING ALPHA-BETA PLAIT DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
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        <location>
            <begin position="80"/>
            <end position="157"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP00060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="267" mass="29161" checksum="FBA92BDDE4BB8267" modified="2014-10-01" version="1">MADLLDMSLDDLINRNRKSGGDHGNFRGRGGGRGRGLGQAHCMSSGPGPTRRTPVFVPYRTGLRMLETGMVEEGGASSGTKLYVSNLHYGVTNDDIEVLFSDVGELKRYAIHCDRTGKSMGTAEVVFARHSDALKAINRYNDLLLDGRPIKIEIIGGDFVAYAVPPSSEGYLGYQSGAFRRYVTCLHVFCIACPHEHVLLFCFGIWQPISLIIYCVVLLVSNSRDGFKQAGRRGQEGQGKKNLAEKVSAEALDADLEKYHEGALLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVT1</accession>
    <name>A0A068TVT1_COFCA</name>
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            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP00400">
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        <property type="gene ID" value="GSCOC_T00032331001"/>
    </dbReference>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8859" checksum="8CF7D60F453641E4" modified="2014-10-01" version="1">MESVINLQHPMSTGVLRFHPFRDMPLLLVKRKKERSEDLRLDDEGEKGSSDQSSRKVHAWIPLLYSVFILVMLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWB4</accession>
    <name>A0A068TWB4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032091001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWB4"/>
    <dbReference type="FunCoup" id="A0A068TWB4">
        <property type="interactions" value="1873"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWB4"/>
    <dbReference type="Gramene" id="CDP00214">
        <property type="protein sequence ID" value="CDP00214"/>
        <property type="gene ID" value="GSCOC_T00032091001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWB4"/>
    <dbReference type="OMA" id="CDAVKTN"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001374">
        <property type="entry name" value="RNI-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="611" mass="65933" checksum="9D1BFF46B8985679" modified="2014-10-01" version="1">MGSSTALSLHSPAKINLWQHKWNQTLQDGQALSSSSRYCAARGAQLFPFAPLNRRSTRKISLTVRAASGGVSRRSASSRRVYRESQAQAPALPAPVMQIASFILPAGAFIVGTFVLWKLVEKVLVPKRKNSLSEENRSSQGVKWSFAPGTNLLSAFGAKVEIESKQRLNEFAKELRLFRTVDMSGRNFGNDGLYFLAEGLAYNQTAEEVSFAANGITADGIKAFDGVLQSNVALKTLDLSGNPIGDEGAKYLRDVLLENSSIQKLQLNSTGLADEGAKAIAELLKKNSALRILELNNNLIDYSGFSGIAEALLENKSIQVLYLNGNYGGPLGAAALAKGLEGNKSLRDLFLHGNSIGDEGIRALIIGLSIHKGKVTSLDIGNNSISARGAFHVAEYVKKSKSLRWINIYMNDIGDEGAEKIAEALRQNRSVTDIDLGGNDIHAKGVAAIAEVFKDNAVLTSLEIGYNPIGPDGVKALAEVLKFHGNIKNLMLGWCQIGAKGAEFIADMLKYNGTISTLDLRGNGLRDEGAICLARSLKVVNEALTTLNLGFNEIRDEGAFAIAQALKANEDVRLTSLNFASNFLTKLGQTALTDARDHVLEMNEKEVSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWE6</accession>
    <name>A0A068TWE6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LOB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032617001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWE6"/>
    <dbReference type="STRING" id="49390.A0A068TWE6"/>
    <dbReference type="Gramene" id="CDP00620">
        <property type="protein sequence ID" value="CDP00620"/>
        <property type="gene ID" value="GSCOC_T00032617001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWE6"/>
    <dbReference type="OMA" id="ATEYMIN"/>
    <dbReference type="OrthoDB" id="1922547at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWE6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31304:SF73">
        <property type="entry name" value="OS01G0511000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="256" mass="28327" checksum="66143B2F21A62BA2" modified="2014-10-01" version="1">MRMSCNGCRVLRKGCGEDCTLRPCLQWIKTPESQANATVFLAKFYGRAGLVNLINAGPDHLRPEIFRSLLYEACGRIINPIYGSVGLLWSGNWQRCQAAVEAVLEGSPIMQVSTDDAAAGGHPITPLKDCDIRHLSKKSNGIHRVRTRNRFKRSGFKSQVDSVPEFMNETTKFSITGWNDDEENDGSEEELMKRAPSHDSFSVETVEPTLVSRAEQGRVVKSETILVGEDDDLVLDLTLGVNPVVRTHLSAGGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXF6</accession>
    <name>A0A068TXF6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00034482001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXF6"/>
    <dbReference type="FunCoup" id="A0A068TXF6">
        <property type="interactions" value="1725"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP01000">
        <property type="protein sequence ID" value="CDP01000"/>
        <property type="gene ID" value="GSCOC_T00034482001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXF6"/>
    <dbReference type="OMA" id="KRGYESW"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXF6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45000">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45000:SF5">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="248" mass="29258" checksum="380BE7A808EC31B5" modified="2014-10-01" version="1">MAKEDDAAADKNPKPNNPWPQQPSRPGYSPDSEKDMKIWGILLFGLIGATATTAAVTQLRRSVDWVYSQLSRSKASWKSASGKTFRTSFQEEAWKRYNRRMQEEYEEEMERVERIRRMQSVFNRERNKYKRSYESWAENGQGAYHQHFQRNDWYWKGDTSYRDQGAKFREAPWASASYPLSHHYSVLGLDRARAKPYTDDEIKSAFRAKAMEFHPDQNQDNQQLAEAKFKEVMISYEAIKTERNNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ62</accession>
    <name>A0A068TZ62_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00036648001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ62"/>
    <dbReference type="STRING" id="49390.A0A068TZ62"/>
    <dbReference type="Gramene" id="CDP01556">
        <property type="protein sequence ID" value="CDP01556"/>
        <property type="gene ID" value="GSCOC_T00036648001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ62"/>
    <dbReference type="OMA" id="EDRPMII"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="423" mass="48158" checksum="3E92F01F9F5A4A7B" modified="2014-10-01" version="1">MIDLCNLKSINIDLVSETAWIQTGVTLGQLYYAIAQKSKTHAFAGGLCPTVGSGGHISGGGVGTLLRKYGLAADNVVDARVMDANGQILDKRKMGEDLFWAIRGGGGASFGVILAWKLKLSRVPEQVTAFTVRRKLNRGNIKLIQRWQNIAHQFPEDLFVRMILQNPAPVIKGGEKIVQISFQGLYLGTADKLVTLSSRYLPEFGIKVRDCFQDPIEIKNCKRKPCIKKECYQVPWIKSALYFASKTPKSSLNYLVSKSSAPAYYKAKSDFVTRPIPDKAWVLLKKMFLEEDSPMMILDPFGGRMSHICKSELPFPHRNGTLYNIQYLVKWKHNNQSESNKHIKWIRKLHKKMEPFVSQSPRAAYINYRDLNLGVNGERYKYEEAKTWGEMYFKDNFEKLARIKSKVDPSNFFRNEQSIPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0T0</accession>
    <name>A0A068U0T0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037133001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0T0"/>
    <dbReference type="STRING" id="49390.A0A068U0T0"/>
    <dbReference type="Gramene" id="CDP01942">
        <property type="protein sequence ID" value="CDP01942"/>
        <property type="gene ID" value="GSCOC_T00037133001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0T0"/>
    <dbReference type="OMA" id="IPHETNQ"/>
    <dbReference type="OrthoDB" id="10262769at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0T0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22687">
        <property type="entry name" value="FHA_MCRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037912">
        <property type="entry name" value="MCRS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025999">
        <property type="entry name" value="MCRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233:SF0">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13325">
        <property type="entry name" value="MCRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="775"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="887" mass="97321" checksum="27C894A84366A0D0" modified="2014-10-01" version="1">MAAAVPVSTAWIPEDDLLLKNAVEAGASLEALAKGAVQFSRRFTFQELRDRWHSLLYDPDVSAQASIRMFELELSGFNPLSRNNRFDHSKVSREVPEKRKIVSIRKQYYSMRKKFRSEFFNPTDLGFPDEPNIHDSSGNVADFRGFDRDPQDSNCVLGNSMQNHFELQESDIEILRSVFAKPTGNASVTSGAVSTRTSYLTGCSNTLEDKQPNGLFRTYGFPEDVSTPLRQDGTPFEANVKSRVMSSFIQNSSVNIGECSGIQEPGLPEIPSNSKLLESLEMQQLSAFDSRKENPRNVLRGSRQECNMNAPAGNSSFHTIGFSAADPNLSLWEPVQDFSASPLPVSLKQGDATQDAEKMLTDDGASNVKNEAVYNGVDSGPLLGVSEGEFGDLPDSLLNLSNEDDILFIDVDGKETRDKSYSDNVHSLLLSSPNDAQEDSFNDIEPQALVTAESCPTDPQGEDLDNSGAITSSTRAGDQNVQHPESAEPSASTFTSNSHALGDGNICCTLNTEDPEIPCNDDIFLLIHPSMSFAPPAAQATPVETMGLSSAASPEQTRQGNLLMDAKDLPRSSTWSQKIGPNILPETRPTCSLVGFGVKSELSDMNSKSFLPRDANKALGDLNQCKSSNANQSIPASRALEDSVSKVDLKAGECSVSFVEVHNTVAGSLKIDMSDSTAVNPSASDQEELGSDKDVPYFSDVEAMILEMDLDPHDQDLHSSKQAEVLRYQYEDAKRTIIRLEQCAQSCLQRSMTSQGALAVFYGRHLRHYIRKTEVVLGRSTDDFDVDIDLRKEGRANRISRRQAIVKMEANGSFYLKNIGKSLISVNGKLVASGQLICLGSSCLIEIRGMSFVFEINQKYARQYINSMSRDSKGKNSKFEWSPDEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U184</accession>
    <name>A0A068U184_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00039645001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U184"/>
    <dbReference type="FunCoup" id="A0A068U184">
        <property type="interactions" value="2885"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U184"/>
    <dbReference type="MEROPS" id="M16.973"/>
    <dbReference type="Gramene" id="CDP02290">
        <property type="protein sequence ID" value="CDP02290"/>
        <property type="gene ID" value="GSCOC_T00039645001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U184"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U184"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="106"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="259"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP02290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="530" mass="59011" checksum="079EC17016CF94AE" modified="2014-10-01" version="1">MAIRRLLTLARRSQRTTTKHLRPFSTSSAAVAPASPSSTPSNFSPPPPTAMIYDRLAENVKSKLKQLEQPDSRFLKYSSPHPARVDHTPVLAAPLTRVTTLPNGLRIATESNLACPTATVGVWIDAGSRFESDETNGTAHFLEHMIFKGTERRAARELEEEIENMGGHLNAYTSREQTTYYAKVLEKDVPRAMDILADILQNSKFEESKITRERDVILREMQEVEGQTEEVIFDHLHATAFQHSSLARTILGPADNIMTITKQHLKDYISTHYSAPRTVIAASGAVKHEEIVDLVKKLFTKLSPTGSTTTELIAKDPAIFTGSEVRMIDDDIPLAQFAVAFEGASWTDPDSIALMVMQSMLGSWSKSAGGGKHMGSDLAQRVGINEIAESLMAFNSNYKDSGLFGVYAVAKPDCLDDLAYAIMYEISKLSYRVSEEDVVRAQNQLKSSLLLHLDGTSPVAEDIGRQLLTYGRRIPYPELFARIDAIDANTIKRVANRFISDKDIAISALGPIQGLPDYNWFRRRTYWLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2S1</accession>
    <name>A0A068U2S1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00041237001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2S1"/>
    <dbReference type="STRING" id="49390.A0A068U2S1"/>
    <dbReference type="Gramene" id="CDP02845">
        <property type="protein sequence ID" value="CDP02845"/>
        <property type="gene ID" value="GSCOC_T00041237001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2S1"/>
    <dbReference type="OMA" id="HAHQKFK"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2S1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46971">
        <property type="entry name" value="CALCINEURIN B SUBUNIT (PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46971:SF4">
        <property type="entry name" value="OS08G0442300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="20068" checksum="B51B839D42D88F1B" modified="2014-10-01" version="1">MGNSSSMLTQYDIEEVQQHCNHTFSQQEIVALYQRFCQLDRNGIGFISSDEFLSVPEFAVNPLSQRLLRMLEGLNFKEFVAFLSAFSSRASLQQKVEFIFKVYDTDGNGKVAFHDMLDILRDLTGQFISEQQREQVLTRVLEEAGYNKDSFLVQSDFMKILGNSGLRMEVEVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3P3</accession>
    <name>A0A068U3P3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Pectate lyase</fullName>
            <ecNumber evidence="4 10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00039517001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3P3"/>
    <dbReference type="FunCoup" id="A0A068U3P3">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3P3"/>
    <dbReference type="Gramene" id="CDP02198">
        <property type="protein sequence ID" value="CDP02198"/>
        <property type="gene ID" value="GSCOC_T00039517001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3P3"/>
    <dbReference type="OMA" id="HIHHICQ"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3P3"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007524">
        <property type="entry name" value="Pec_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF181">
        <property type="entry name" value="PECTATE LYASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04431">
        <property type="entry name" value="Pec_lyase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104016" description="Pectate lyase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP02198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="476" mass="53218" checksum="C01E42268843251F" modified="2014-10-01" version="1">MGEPVSKLVCVFLCAFTIVVVPTLITAQGSGSAEEEYWRIRAEEAWNHTLKAYEANPHTVIGAFNKQASENEMPGKTAAQDDKLTKLNLPPCCHTQQFLSEKNSTRRELRGKKWGGGCLATNPIDRCWRCQPNWADNRKRLADCVVGFGRGTTGGKNGAFYVVTDSSDDSILAPKPGTLRHAVIQKEPLWIIFERDMVIRLTQELIMQGDKTIDGRGVSVHIAYGAGITIQFVKNVIIHGLHIHDIHQGSGGLVRDSVDHFGIRTMSDGDGISIFGSSNVWIDHVSMWKCYDGLIDAVEASTAITISNSHFTDHNEVMLFGASDSQSKDAVMQITVAFNHFGKRLIQRMPRCRWGFIHVVNNDYTHWEMYAIGGSQHPIIISQGNRFIAPPDIFKKEVRRTVTKRDYAEEARWKEWTWRSEGDLFMNGAFFVQSGDPDFTKKHPEIFDGIAPADSSEVTWITRFAGALMCRPGSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U598</accession>
    <name>A0A068U598_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00015305001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant rapid alkalinization factor (RALF) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U598"/>
    <dbReference type="STRING" id="49390.A0A068U598"/>
    <dbReference type="Gramene" id="CDP03492">
        <property type="protein sequence ID" value="CDP03492"/>
        <property type="gene ID" value="GSCOC_T00015305001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U598"/>
    <dbReference type="OMA" id="NCAFNET"/>
    <dbReference type="OrthoDB" id="1863600at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U598"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008801">
        <property type="entry name" value="RALF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136:SF34">
        <property type="entry name" value="OS12G0541700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05498">
        <property type="entry name" value="RALF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP03492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="66" mass="7634" checksum="D96256C672EB3730" modified="2014-10-01" version="1">MVIMESDNSRKGLAQVQQFICYAAMRRDSIPCNRRGHSYYNCDYHGPANPYTRGCTDITRCPRNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5Q1</accession>
    <name>A0A068U5Q1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00015899001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5Q1"/>
    <dbReference type="FunCoup" id="A0A068U5Q1">
        <property type="interactions" value="2605"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5Q1"/>
    <dbReference type="Gramene" id="CDP03504">
        <property type="protein sequence ID" value="CDP03504"/>
        <property type="gene ID" value="GSCOC_T00015899001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5Q1"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5Q1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000054">
        <property type="entry name" value="DNA mismatch repair protein PMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="230"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="722"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP03504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="103355" checksum="DDC918B84A762C70" modified="2014-10-01" version="1">MATKGGPSMMLDKDSATIRPINKGVVHRICSGQVILDLSSAVKELVENSLDAGATSIEIALKDYGEESFQVIDNGCGISPHNFKVLALKHHTSKISDFPDLQSLATFGFRGEALSSLCALGELTVETRTQNEAVATHLTFNYSGLLVTERKTARQIGTTVTVKKLFSSLPVRSKEFHRNIRKEYGKLITLLNAYALIAKGVRLVCTNTAGKNAKSVVLRTQGSGSLRDNIITVLGMNTFTCLEPVEVSISDGCTVDGFLSKPGYGSGRNLGDRQFFFVNGRPVDMPKVSKLVNELYRGANSRQFPIAIMNFTVPARSYDVNVTPDKRKIFFSDEVSILRTLREALEKIYSPDSASYLVHELDEQSKKKSTSKFHFKQENSQLQRRQSSHDDCDKAEACDKKQLLDGDTLCIADKKDLNDISIVEVKDGNLNHSAGRDFLLRVHSTKKEDTLSRCSYNKCKDPSSSTEKKPLPLSSIPPEESCDDNSRLQCRSTIFQSSLKKFVNITKRKHESISNALSEVPLLRSSLTSCQSKELRFGKHNTHPNLPVNSMIIDDSDEFSNNGPEPSECVRVNQVCHERGTAFPDDKDMENRESTQQLKLEETVLPIPTSNNLENMSEDLLDETIRLESSDPSSDSPISSLNVGSTLQFSFKELTTRRQQRLARLHILNHTSRKMKIKGSYTAATLELSQMTNDEGKSRALAAATSELERLFKKEDFERMKVIGQFNLGFIIAKLDHDLFIVDQHAADEKYNYERLSQSTVLNQQPLLQPLRLELSPEEEIVTSMHMDIIRRNGFSLEEDVHAPPGQRFKIKAVPFSKNIIFGVADVKDLLSILADSQGECSIIGSYRSDTADSVCPPRVRAMLASRACRSSVMVGDPLGRNEMQKILEHLAGLKSPWNCPHGRPTMRHLVDLTTVRGRINVEEEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5S2</accession>
    <name>A0A068U5S2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00016408001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5S2"/>
    <dbReference type="FunCoup" id="A0A068U5S2">
        <property type="interactions" value="1284"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5S2"/>
    <dbReference type="Gramene" id="CDP03905">
        <property type="protein sequence ID" value="CDP03905"/>
        <property type="gene ID" value="GSCOC_T00016408001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5S2"/>
    <dbReference type="OMA" id="HSELYDH"/>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5S2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000014">
        <property type="entry name" value="FHA domain-containing protein FHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="347" mass="38076" checksum="22AC148116B8ED29" modified="2014-10-01" version="1">MGSSGGGSDVEAGFAKLQGEDFEYYMQTYSIVLGRNSKKSTVDVDLSSLGGGMNISRHHARIFYDFQRRRFALEVLGKNGCFVEGVLHLPGNPPVKLDSQDLLQIGDKEFYFLLPVRSILGGPIGPRHHVNVNVNYPPAGAAGATPPPLPPHGQHMGLPPPPGAMGKKGLARGREYYEEEYDEDGGEDGGSGGAKKIRRGDGIDGSGYGYASGSSGGRTAISGQLDKKLDGRSRVDRDADNQQLQQLEEKDVVSSVATVLSDMCGPGEWMPMEKLHKELLDKYRNVWHHGRLRRYLTSEDFQSPEAKAKPWYGLLMLLRKYPEHFVINTRSKGRVTLEFVSLVSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U608</accession>
    <name>A0A068U608_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016155001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U608"/>
    <dbReference type="Gramene" id="CDP03697">
        <property type="protein sequence ID" value="CDP03697"/>
        <property type="gene ID" value="GSCOC_T00016155001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U608"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="62" mass="7153" checksum="503946EECC52E0BD" modified="2014-10-01" version="1">MCLHGLKEVRNRKAGFLPPCVCVSVILFSNIIDWGSSFQFSFLMRGYLRIHAVWFSRGETCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U691</accession>
    <name>A0A068U691_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00016106001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U691"/>
    <dbReference type="STRING" id="49390.A0A068U691"/>
    <dbReference type="Gramene" id="CDP03669">
        <property type="protein sequence ID" value="CDP03669"/>
        <property type="gene ID" value="GSCOC_T00016106001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U691"/>
    <dbReference type="OMA" id="PANYRIC"/>
    <dbReference type="OrthoDB" id="20727at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U691"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177">
        <property type="entry name" value="CASKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177:SF103">
        <property type="entry name" value="PGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="457"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="622" mass="69981" checksum="01EBDD5512CFFA17" modified="2014-10-01" version="1">MCHFIASRDTKLMGRRNHDSETPFFLAALHGRKDAFLCLHSFCGSDQGYSFCRRNDGETILHCAIAGEYFELAFQIIHLYEDLVSCVNEQGLSPLHLLATKPSAFKTGSSIRGYYKIIYHFIIIDKLEPRTHYRQPLFPELKYSENAKYPENYQSCANFGWLIGRAFQLLVLGRGKNDGGQQADAEDPDGKHSEQKALHQRQRAEGRPAFPAIYVTCFDAIKFMSKAMLIIFGLGSMEIVKLQNRKQKHVWSVQVLDELLKRTSRHEYEDNGQNPADAQLLKDDGTKPYSLMDGALIPPPPAEGGNGQDTETGKRETPILIAAKNGVVEMVYKILQLFPVAVHDMNSDKKNVVLLAVENRQPYVYRLLLDMKIMRDSIFRKVDKDGNTALHLAARLGEYRPWLIPGAALQMQWEIKWYEYVKKSMPQHFFARVNKEGRIPKDVFTETHQELVKSGGQWLTNTSQSCSVVAALIATVAFATSTTVPGGVKQDIGTPTLENEPAFDCFAISSLVALCFSVTSLVMFLAILTSRYQEKDFGTSLPSKLLLGLTSLFVSIASILISFCSGHFFVLKDKLKFAAFPVYAVTCLPVTLFAIAQFPLYFDLIWATIHKVPQRSYRAIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6Z9</accession>
    <name>A0A068U6Z9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00016479001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
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                <person name="Zheng C."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Bernard M."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP04605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="462" mass="49056" checksum="8697545F1D3105D8" modified="2014-10-01" version="1">MAEKGEERDTGSSGGKNHGQGGEAAAEGGGGVTSPVRRVLIISAGASHSVALLSGNVICSWGRGEDGQLGHGDAEDRFSPTQLSALDGLEIVSVNCGADHTTAYSELRMEVYSWGWGDFGRLGHGNSSDLFTPQPIKALHGLKIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGTTEDSLVPQKIGAFQGVPVRMVAAGAEHTAAVTEDGELYGWGWGCYGNLGLGDRNDRLIPAKVSAVEGDKMILVACGWRHTISVSSSGDLYTYGWSKYGQLGHGDFEDHLVPHKLNALSKSFISQISGGWRHTMALTADGKLYGWGWNKFGQVGVGDNIDHCSPVQVRFPLDQALVQISCGWRHTLAVTERQNVFSWGRGTNGQLGHGESADRNVPKIIEALSVDGSSGQVIESSKVDPSSEKLSVSPTDRYAVVPDDNSQTSTLLSGNGSDVNVPETDVKRIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7X7</accession>
    <name>A0A068U7X7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-adenosylmethionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00018709001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7X7"/>
    <dbReference type="Gramene" id="CDP04665">
        <property type="protein sequence ID" value="CDP04665"/>
        <property type="gene ID" value="GSCOC_T00018709001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7X7"/>
    <dbReference type="OMA" id="DEDNTAM"/>
    <dbReference type="OrthoDB" id="909524at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7X7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP04665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27806" checksum="806AAE3C98006E0A" modified="2014-10-01" version="1">MPQVYAMNGGNGPQSYNQNSSFQRGAVEVAKELIKEEIDKELDVKQLSSTSVHPFRIADFGCSTGPNTFVAMKVIREALEEKLRKEGLASEVPEFQVFFNDHISNDFNTLFASLPQERHYLAAGVPGDFHKVLLPKASLHFAHSSCSLHWLSDVPKEVTDNTSPAWNKGKIHYGGAKKEVLEVYASQFAKDLESFLNARAHELVDGGLMALVIPAVLDAIRESQTTIVTEKELEVLGYCLMDLAKKVRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7Y2</accession>
    <name>A0A068U7Y2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00018645001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7Y2"/>
    <dbReference type="Gramene" id="CDP04631">
        <property type="protein sequence ID" value="CDP04631"/>
        <property type="gene ID" value="GSCOC_T00018645001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7Y2"/>
    <dbReference type="PhylomeDB" id="A0A068U7Y2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="83" mass="9554" checksum="CE38D3E6D65AD54D" modified="2014-10-01" version="1">MKPHLNCPYFLGKDLISIELMKLQVRAYVKGIWHYVHPKSTRVDDPLLNPRMEPNLLRLGFVVAKKVGYFHQQECCVDASLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U933</accession>
    <name>A0A068U933_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00018875001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U933"/>
    <dbReference type="STRING" id="49390.A0A068U933"/>
    <dbReference type="Gramene" id="CDP04777">
        <property type="protein sequence ID" value="CDP04777"/>
        <property type="gene ID" value="GSCOC_T00018875001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U933"/>
    <dbReference type="OMA" id="DHIDARS"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U933"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051357">
        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
    </dbReference>
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        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660:SF86">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC SUVH6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YDG" evidence="11">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="234"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="297"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP04777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49996" checksum="6117C547914707FA" modified="2014-10-01" version="1">MLLKKQQKWVNTKPCFGHVPGVEIGDQFRFRVELALVGLHHEQMAGINHATIEGKEYANSVVDSGLRRYGNRAASPDILLYSGQGQTFEDQKLQRGNLALKNSMDAKYPVRVIRKTILGSVDATTTTKKMYIYDGLYKVRKFWPERSKSGKLSLMFELVRLSRQPDCNHQSITKPRRSLKYLEDNNAETGYDVSGGKEKVPIMVVNEISIEKPANFTYITKIMYPHWYQVSLPEGCDCVGGCSDSIRCPCAVKNGGELPFNEEGSVVRAKKMVYECGPNCKCPPSCQNRVSQHGPRLPLEIFRTKSTGWGVRSQVEIPSGSFICEYAGELLQDKEADLRDNDEYLFDLDDGEGFTIDAAKYGNVGRFINHSCSPNLYAQNVLYDHDDKRVPHVMLFATKKIPALKELSYDYNYKLNRVLDANGNIKMKKCFCGSRKCIGRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9C6</accession>
    <name>A0A068U9C6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sec-independent protein translocase protein TATB, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00020117001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9C6"/>
    <dbReference type="FunCoup" id="A0A068U9C6">
        <property type="interactions" value="1368"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9C6"/>
    <dbReference type="Gramene" id="CDP05165">
        <property type="protein sequence ID" value="CDP05165"/>
        <property type="gene ID" value="GSCOC_T00020117001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9C6"/>
    <dbReference type="OMA" id="PFRFSTW"/>
    <dbReference type="OrthoDB" id="2017985at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9C6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.3310:FF:000003">
        <property type="entry name" value="Sec-independent protein translocase protein TATB, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33162">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33162:SF3">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATB, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01506">
        <property type="entry name" value="TATBPROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP05165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30338" checksum="486A8F91AE76EF1A" modified="2014-10-01" version="1">MASAILSPTASSLRLSSLSSSSSTNRRHTFWGLSSSAISVSSQSSSFDFSIWLPQLGLCQTHQWTGLKRFGISSAQHLIKLERSGKRKRIGVYASLFGVGAPEVLVIGVVALLVFGPKGLAEVARNLGKTLRAFQPTIRELQDVSREFKSTLEREIGLDDIQTSTKSTLSSNPTKTTSSPSSDPSSEVSPTEIDPNGSASPGKPFSSEAFLKITEQQLRAAAAKEEGESKSPGENQPEIQNLAAEQQIETASSGESQSKIETQNQGSPQDAASAMPSPGKPERDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9U3</accession>
    <name>A0A068U9U3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF599 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019852001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9U3"/>
    <dbReference type="Gramene" id="CDP04969">
        <property type="protein sequence ID" value="CDP04969"/>
        <property type="gene ID" value="GSCOC_T00019852001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9U3"/>
    <dbReference type="OMA" id="YHHAGFV"/>
    <dbReference type="OrthoDB" id="761598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9U3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006747">
        <property type="entry name" value="DUF599"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31168:SF1">
        <property type="entry name" value="DUF599 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31168">
        <property type="entry name" value="OS02G0292800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04654">
        <property type="entry name" value="DUF599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30083" checksum="43DC487F6B65A7D1" modified="2014-10-01" version="1">MEEKVLDYVLVPVGLGGMLVYHVWLFHQIVKLPTSTVIGINAINRRFWVQAMMKDASKNGVLAVQTLRNNIMASTLLASTAIMLSSVIAVLMTGMSRQWGGEHDHEPDSSSSSSPTGMWFLDVVGDKSRLAFSIKYFSILVCFLVAFLFNVQSIRYYSHASILINVPTDHHPRQAHHHYCVTPDYVAATVNRGSYFWSLGLRAFYFSFPLFFWIFGPIPMFLCCVLLVFLLYFLDLTLDLGWVGATVTQHEIENQPFRDENDRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA30</accession>
    <name>A0A068UA30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00020335001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA30"/>
    <dbReference type="FunCoup" id="A0A068UA30">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UA30"/>
    <dbReference type="Gramene" id="CDP05331">
        <property type="protein sequence ID" value="CDP05331"/>
        <property type="gene ID" value="GSCOC_T00020335001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA30"/>
    <dbReference type="OMA" id="WDANENE"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044656">
        <property type="entry name" value="HSP14.7/HSP23.5/HSP23.6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46991">
        <property type="entry name" value="23.5 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46991:SF11">
        <property type="entry name" value="SMALL HEAT SHOCK PROTEIN HSPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="97"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP05331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="203" mass="22828" checksum="FBBD8CFA21CED695" modified="2014-10-01" version="1">MAASLALKRLVSSTLLSRSVNSLRPAASAASSRLFNTNVARDYDDDDDERGLDVDRRSNCPLYNRRDYSPYFGVFDPFSTRSVSQLLDLVNQFSEPTFASGVRRGWDIKETAEGLNLSLDMPGLGKEDVKVSVEQNTLIIKGEGQKESEDAERGRRFSSRLDLPEKTYKTDGIKAEMKNGVLKVFIPRVKEEERSDVFHVNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAD6</accession>
    <name>A0A068UAD6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00020188001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAD6"/>
    <dbReference type="FunCoup" id="A0A068UAD6">
        <property type="interactions" value="2408"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAD6"/>
    <dbReference type="Gramene" id="CDP05222">
        <property type="protein sequence ID" value="CDP05222"/>
        <property type="gene ID" value="GSCOC_T00020188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAD6"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAD6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04160">
        <property type="entry name" value="Arfrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000914">
        <property type="entry name" value="ADP-ribosylation factor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP05222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23048" checksum="91F66CEACCE8FB84" modified="2014-10-01" version="1">MFSLFYGLWKYMFSKTEFHVLILGIDKAGKTTLLEKLKSQYSNLEGLPPDRIVPTVGLNIGRVEVSNTKLVFWDLGGQPGLRSIWEKYYEEAHAVVYVVDAACPSRFEDSKSALEKVLRHEDLQGAPLLILANKQDLAQAVTAEEVARYLDLKKLDERVYTFQAVSAYDGTGIKESVDWLVDVMERSKRTEMLRARASVGISGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAN8</accession>
    <name>A0A068UAN8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00020783001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAN8"/>
    <dbReference type="Gramene" id="CDP05625">
        <property type="protein sequence ID" value="CDP05625"/>
        <property type="gene ID" value="GSCOC_T00020783001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAN8"/>
    <dbReference type="PhylomeDB" id="A0A068UAN8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="93" mass="10792" checksum="8517C70CA580F527" modified="2014-10-01" version="1">MTAYRYHSFCAYNGDDDLFSSDLSEDQLRQRLGHMSRTPCQIIFSMADEHESEYVDKKALVERLCRAMGGAEKVEIEWGNHALSNRGWDDLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAS9</accession>
    <name>A0A068UAS9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00020836001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAS9"/>
    <dbReference type="FunCoup" id="A0A068UAS9">
        <property type="interactions" value="1809"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAS9"/>
    <dbReference type="Gramene" id="CDP05655">
        <property type="protein sequence ID" value="CDP05655"/>
        <property type="gene ID" value="GSCOC_T00020836001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAS9"/>
    <dbReference type="OMA" id="WRAVITI"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAS9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000068">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP05655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="360" mass="38675" checksum="E78ADF1B344D8B5A" modified="2014-10-01" version="1">MSYSSAISLFIYELIATANYIGTPGKGILAADESTGTIGKRLSSINVENVESNRRALRELLFTTPGALECLSGVILFEETLYQKSAAGKPFVDVLKEGGVIPGIKVDKGTVELPGTNGETTTQGLDGLAQRCQQYYTAGARFAKWRAVLKIGPNEPSQLAINENANGLARYAIICQQNGLVPIVEPEILVDGSHDIEKCADVTERVLAAVYKALNDHHVLLEGTLLKPNMVTPGSEAPKVAPEVIAEYTVRALQRTMPAAVPAVVFLSGGQSEEEATRNLNAMNRLKTKKPWSLTFSFGRALQQSTLKAWAGKEENIPKAQAAFLSRCKANSDATLGKYEGGASLGEGASESLHVKDYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBK7</accession>
    <name>A0A068UBK7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021164001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBK7"/>
    <dbReference type="Gramene" id="CDP05861">
        <property type="protein sequence ID" value="CDP05861"/>
        <property type="gene ID" value="GSCOC_T00021164001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBK7"/>
    <dbReference type="OMA" id="TLMMEEM"/>
    <dbReference type="OrthoDB" id="1577729at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBK7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="192" mass="21505" checksum="DA860AB998B8E54C" modified="2014-10-01" version="1">MGIWDELQFSVSRLVNRKPSGPSKRPSDTITALHGQPATALVSRATKFVDAVRSNGAQKLDDYFPGPHRREKISRVLTNLGKFAVDSAIEKCLESVTGGIQVYQIVREGLKDQPKSRPSNEIKKQDLTVATEEMQAKMEKMQEDVNILKQQNQTCAECSRELEPLKELSDEPIQTPTSAQTDKKKVVIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE69</accession>
    <name>A0A068UE69_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00023377001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE69"/>
    <dbReference type="Gramene" id="CDP06504">
        <property type="protein sequence ID" value="CDP06504"/>
        <property type="gene ID" value="GSCOC_T00023377001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE69"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="85" mass="10045" checksum="CCE9EB7BE317682A" modified="2014-10-01" version="1">MNYMIRDDGRLQVTSSGYENFHLHRKRKKQKPKKAQQPLQFCTWLAGILVSENQRPSQQPWIRDLKCSVCLAFRRQGSFDFDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEG8</accession>
    <name>A0A068UEG8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023905001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEG8"/>
    <dbReference type="STRING" id="49390.A0A068UEG8"/>
    <dbReference type="Gramene" id="CDP06871">
        <property type="protein sequence ID" value="CDP06871"/>
        <property type="gene ID" value="GSCOC_T00023905001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEG8"/>
    <dbReference type="OrthoDB" id="1935348at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEG8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="225" mass="25083" checksum="92A55E817F6DB0A1" modified="2014-10-01" version="1">MVVCRLRKNIEFHLDDSPRRKPQEGRHPSAANNNATASCEIEQTDVSEGAMLGDCWSKECSSNNNSLSTEQIESGFECDDKAPNELSPYAPSSHQKECNSIEEDYFADIMKDDIIQLDDSAIYASPQHLQTVAPEPESQNKSKQPAEDTHPVVFLSRAQQIEGSDWEGKNLKTVKLIRLTGTESTKLTSLPSSSVKRICSSRQNCWLDYSLTWGLSVYPYSSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEW9</accession>
    <name>A0A068UEW9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021561001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEW9"/>
    <dbReference type="STRING" id="49390.A0A068UEW9"/>
    <dbReference type="Gramene" id="CDP06163">
        <property type="protein sequence ID" value="CDP06163"/>
        <property type="gene ID" value="GSCOC_T00021561001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEW9"/>
    <dbReference type="PhylomeDB" id="A0A068UEW9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="9545" checksum="4C3449B17A0EF8DD" modified="2014-10-01" version="1">MFLFVGSFFHKYLLCCPYHFFIELNFHYTETNIWRIENFQTVSLPKSDYDKFYLHDSYIVFHVHTTSNISYLYNIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UF39</accession>
    <name>A0A068UF39_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022890001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UF39"/>
    <dbReference type="Gramene" id="CDP06208">
        <property type="protein sequence ID" value="CDP06208"/>
        <property type="gene ID" value="GSCOC_T00022890001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UF39"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="104" mass="12214" checksum="78D3BB5B2CE70C13" modified="2014-10-01" version="1">MDSELLTQNETKKKKTKTQPKITTSPPKRNISPNPFFFSSFLSFLFFFFFFFFSLYHFRFFFFFLSGLLKKLQPVAMAAAGEVFGCQILPKYTLPLVFSSRICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGY5</accession>
    <name>A0A068UGY5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00024826001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGY5"/>
    <dbReference type="FunCoup" id="A0A068UGY5">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGY5"/>
    <dbReference type="Gramene" id="CDP07537">
        <property type="protein sequence ID" value="CDP07537"/>
        <property type="gene ID" value="GSCOC_T00024826001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGY5"/>
    <dbReference type="OMA" id="KWLFTRM"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGY5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000446">
        <property type="entry name" value="Microtubule associated serine/threonine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000147">
        <property type="entry name" value="probable serine/threonine protein kinase IREH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058783">
        <property type="entry name" value="IREH1/IRE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF354">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE IRE4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26031">
        <property type="entry name" value="IREH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="696"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123426" checksum="54021D59BA91D073" modified="2014-10-01" version="1">MAAEPSRNSLTETGIPTGLNRIKTRRVASSKDKERRSSRIEDSEKLNADSPGSLRPYVKQKFGALVKGRVRINSPREGLKTKRRARWFTSHLSKDSDQVADDVPQQLECNDSQTGQVRTMMKHTTAKQSALEVTSNHKMHKGLKSFSHELGPKGGIPSVQPRARSFNDMKELLRSLHSRFDAAKEVVNTELDCFSKELMEILQDDSLSQEGHRMAEQLLILAQECTEMAASKFRTKCEEIVQDLTAKRQQCQAGLLKWLLTRMLFILTRCTRLLHFEKDAEPVDGKSLHKFQECLKSIPSIEVNWFVNQEMAGSESDYAINLKNDSKRNLQKRNHAYTLFRPSQHRFEAAVQQVDAMFPKDFTSIGQNLPSETTCVLPNVQEVDELGGRFSEKSTNRASINVSKEQENYMEDSNLVICRICEELVPITHLESHSYICAYADKCYLNSLDVNERLIRLAELLEQLVESRNLSIQATDESPEYSRMQLADSAVASEVYSPKVNEFRNRGMDGMFEDIHEMDTACIEDSQIASFINSKGYWGSKLNLYGPPSSTGSMTSASSTNTPRAGSFDLFWLDHNNPSELEDVKQMADLADIARCVAGTDLSDEGSNEFLLACMEDLQDVLQQSKLRALVVDTFGGRIENLMREKFLLACNLVDPKSDIQRPESAKMLLDNGSQSSTISTPSHPLHKERTSIDDFEIIKPISRGAFGKVYLARKRTTGDLFAIKVLKKMDMLRKNDIDRILAERNILITVRNPFVVRFFYSFTSTDHLYLVMEYLNGGDLYSLLQKVGCLEEDVARIYISELVLALEYLHSLGIVHRDLKPDNILIAHDGHIKLTDFGLSKIGLMNSTSDLSRCETKENNGSGDHGQNNPDTVDRCQRSAVGTPDYLAPEILLGTQHGYAADWWSVGIILFELITGFPPFTAELPEIIFDNILNRSIPWPSVPIEMSHEAQDLIDRFLDHDPDLRLGAKGASEVKAHPFFRGVDWDNLALQKAAFVPQPESMDDTSYFVSRYNSIGLQDDGDCSDTASDVSDLCSNSGLEKMDECGDLAEFDPSPLDLSSINFSFKNLSQLASINHDVLLQGGKDSSKCSSPSRNPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH53</accession>
    <name>A0A068UH53_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024893001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH53"/>
    <dbReference type="STRING" id="49390.A0A068UH53"/>
    <dbReference type="Gramene" id="CDP07592">
        <property type="protein sequence ID" value="CDP07592"/>
        <property type="gene ID" value="GSCOC_T00024893001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH53"/>
    <dbReference type="OMA" id="NEWEVSE"/>
    <dbReference type="OrthoDB" id="757296at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF14">
        <property type="entry name" value="INACTIVE PROTEIN KINASE SELMODRAFT_444075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="408"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="731" mass="81558" checksum="8F423FD44B9DA071" modified="2014-10-01" version="1">MQISNATLTPRSAAGKMSSEQVIVAVKAEKVITKTAMAWALTHVVHPGDCITLLAVFPEEKTGRRRFWGFPRLKGDCRAAAGGADLTSTNKLPDRIGQISESCSQMVLQFQDRIDVRVRIKVVSATPAGTVAAEAKDNAAKWVVLDKKLKLELRHCMDQLHCNIVVMKGSQPKVLRLNLECPDEIQTPFYSAAASPVLDVQKLHGQRMKHSTPVSSPEEPSTSYTKTSGETSLSSPDTATSKFLVYQQNPLYEKLTTGKHTPSHKPNGFGHPLALPDSVEERTVTLSMSSENLNLDDKRIFWIPQNHKISEKAQEIGDCQNGLQNTALPMRDDHHHLVPCMLTEGHKHNLTYGKDVEFNSNIRDAVSLCRTLSTPPPLCSQCQQKAPAFGKPPRQFLYEELEEATDGFSDMNFLAEGGFGLVYRGILRDGLVVAIKQLKFSGSQRDADFCREVRVLSCAQHRNVVLLIGFCVEQKRRLLVYEYICNSSLDLHLHGNLGTILDWDMRLKIAIGTARGLRYLHEDCRVGCIIHRDLRPHNILLTHDFEPLVADFGLARLHREWELCDEEQVIGTYGYLAPEYFTDAKVTEKVDIYAFGLVLLELITGEKTGALPNYSGQQFLFKNFHPLGTLEESHSLADKQRFLDPCLVSYELQSFPYELRAMSHAASLCLQKDPDLRPPMSKVLRILEGGGKVVPLVLDSNSIGSRSGHINGLNPGISTTSRRKHSRRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHE2</accession>
    <name>A0A068UHE2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00025548001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHE2"/>
    <dbReference type="STRING" id="49390.A0A068UHE2"/>
    <dbReference type="Gramene" id="CDP07985">
        <property type="protein sequence ID" value="CDP07985"/>
        <property type="gene ID" value="GSCOC_T00025548001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHE2"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="148" mass="17124" checksum="E18F6B459896039F" modified="2014-10-01" version="1">MEQHDIKEDEFGFSRNYFLAKELGNSNKKSGHKLADIDVIDEQELREALANIEQKHEKEIDDFWVLLVGFSECGECSSRGGVKFFRLCILESCDVKIIFLCLFGFQHAPNVFICFFVWQLARFLSRYSIGESGLVSWNFCWKTTGCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIC5</accession>
    <name>A0A068UIC5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00025547001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIC5"/>
    <dbReference type="STRING" id="49390.A0A068UIC5"/>
    <dbReference type="Gramene" id="CDP07984">
        <property type="protein sequence ID" value="CDP07984"/>
        <property type="gene ID" value="GSCOC_T00025547001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIC5"/>
    <dbReference type="OrthoDB" id="1631570at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="105" mass="11810" checksum="9E5D77B7EBB370E3" modified="2014-10-01" version="1">MDEQMDRRTLLESYVCTKQPSEFRWQLGSLTQVCFYNGFWVVVEDVDKAPPDVQSILLPLLEGASSFITGHGEAIRVHKGFRLFTTVTSSKLDISSIKEGSCCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJS3</accession>
    <name>A0A068UJS3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ferric-chelate reductase (NADH)</fullName>
            <ecNumber evidence="13">1.16.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00027870001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NAD(+) + H(+) = 2 a Fe(III)-siderophore + NADH</text>
            <dbReference type="Rhea" id="RHEA:15061"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.16.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.7" evidence="13"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJS3"/>
    <dbReference type="FunCoup" id="A0A068UJS3">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJS3"/>
    <dbReference type="Gramene" id="CDP08775">
        <property type="protein sequence ID" value="CDP08775"/>
        <property type="gene ID" value="GSCOC_T00027870001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJS3"/>
    <dbReference type="OMA" id="MTRYYIY"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJS3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140618">
        <property type="term" value="F:ferric-chelate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000039">
        <property type="entry name" value="Ferric reduction oxidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF41">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="326"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP08775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="715" mass="80105" checksum="B0DD8CB03003D869" modified="2014-10-01" version="1">MDTRVATRSPQAGGNSVVQGMIMALLVVVSAGYIFIWIMVPTNTFKQHWLLKIRAESNTTYFGSQGANFLVFTFPVLFVAALGCVFLHLGKKRSNEHDSKRRDGKNRTVAWKRPVIIKGLGIVSRIELAFLVMFIALLVWFYTVYVRNGFDSITPKSAAKSGMKVWQAKLGSASLRLGLLGNLCLTLLFFPVTRGSSVLQLFGLTSEASIKYHIWLGHTVMTLFTAHGVCYIIFWAATHQISEMTKWAKADISNVAGEIALVAGLAMWATTFPRIRRKMFELFFYTHHLYIIFVLFFVLHVGIAFACLMLPGFYLFMIDRYLRFLQSRQNVRSVSARILPCETVELSFSKTKGLSYTPTSILFLNVPSISKLQWHPFTITSSSNLEPEKLSVIIKGDGSWTKKLHEMLSSPSSVDHLDVSIEGPYGPTSTDFLRHELLVMVSGGSGITPFISIIRELMYASEILKCKTPSILLIPSFKNSSDLTMLDLLLPIVGSPAEFSNFALQIEAYVTREKQPAPEGKKSLRTVWFKPKPSDSPVAPILGKNSWLWLGAIISASFIIYLIFIGILTRYYIYPIDHNTNGVYSWSSRAVLNILFMCISIIIAATAAFLWNKKQNAMENKQIQNLEGATPVASPNSWFYNADRELESLPQQSLVLSTNLHYGERPDLKKILFERKESSVGVLVCGPKKMRHEAANICSSGLGANLHFESISFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKJ0</accession>
    <name>A0A068UKJ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00028245001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKJ0"/>
    <dbReference type="FunCoup" id="A0A068UKJ0">
        <property type="interactions" value="2389"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKJ0"/>
    <dbReference type="Gramene" id="CDP09060">
        <property type="protein sequence ID" value="CDP09060"/>
        <property type="gene ID" value="GSCOC_T00028245001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKJ0"/>
    <dbReference type="OMA" id="KNRPTMH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKJ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000258">
        <property type="entry name" value="Probable serine/threonine-protein kinase PBL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="74"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP09060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="406" mass="45166" checksum="2F59461FE66E3F63" modified="2014-10-01" version="1">MGICLSARIKAESPYHTGLTSKNVSTDGNSLKSSSGKVSSGSVPPPPRSEGEILQSPNLKSFSFSDLKMATRNFRPDSVLGEGGFGSVFKGWIDENSFAATKPGTGVVIAVKRLNLEGFQGHREWLAEVNYLGQFCHPHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSWNLRLRVAVGAAKGLAFLHSAENKVIYRDFKTSNILLDSSYNAKLSDFGLAKDGPTGDKSHVSTRVMGTYGYAAPEYLATGHLTSKSDVYSFGVVLLEMLSGRRAIDKNRPTGEHNLVEWAKPYLTNKRKIFRILDNRLEGQYSLDVGYKAANLAFRCISMDPRFRPTMNEIVKELEHIQDSNSKEKIGNNAPARSRPRRLSADDARKRNIPAAYPRPSASPLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKU1</accession>
    <name>A0A068UKU1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00026949001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKU1"/>
    <dbReference type="STRING" id="49390.A0A068UKU1"/>
    <dbReference type="Gramene" id="CDP08193">
        <property type="protein sequence ID" value="CDP08193"/>
        <property type="gene ID" value="GSCOC_T00026949001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKU1"/>
    <dbReference type="OMA" id="RDKNIMT"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKU1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000714">
        <property type="entry name" value="Kinase family with leucine-rich repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000666">
        <property type="entry name" value="Kinase family with leucine-rich repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF109">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657776" description="Protein kinase domain-containing protein" evidence="18">
        <location>
            <begin position="30"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="651"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="984" mass="107833" checksum="8F765021EBA1FE03" modified="2014-10-01" version="1">MTELTLTFSKIPQLLLYFLLISLPLLVNSQASVTERSILLNLKEKWGNPGALQSWNSTSSPCSWREINCSGGGTVTGIHLSDKSISGAIPDFICNLKNLTSIALANNFIFQTFPTSFGNNFTGDIPPAIGNLTELKTLYLHSNLFNGTFPAEIGNLSNLEVLGMAHNQFSPAAIPPEFGKLSKAKFIWMAGTNLIGQIPESFSSLANLEHLDLALNDMDGGIPSGLFLLKNLSVVLLYRNWFSGPIPSVIESLNLTQMDLSINRLTGIIPADVGKLQQLQFLLLYSNQLEGEVPASIGLLPGLINFRIFNNKLSGVLPPELGLHSKLEAVEVSNNQFTGNIPENLCAGGTLFGVVAYSNNLNGGIPKSLETCDTLRTIQLHYNGLSGEVPAGIWTLKNMTSVMLSNNSFSGGLPRMVAWNLTRLEIDDNKFSGQIPVEISSWAKLTVFKAGNNMLSGPIPVQLTNLSQLITLTLDGNYLSGGLPSQIISWISLTNLNLSRNDLSGPIPSAIGSLPDLLDLDLSENQLSGSIPPELGSLKLTTLNLSSNRLAGKIPSEFDNMAFERSFLNNSHLCAINLISNLPSCNVKSQRSNKLSPRILAVVLVLVVIAFLVTAVMTLFWKKKQRCDLATWKLTSFQRLDFTEENILSRLTEGNMIGSGGSGKVYKIPVHRPGEYIAVKKIWSSKKLDHKHESEFLAEVQILGSIRHSNIVKLLCCISSEDSKLLVYEYMENHSLDRWLHGKKKKPSSLTTPVQNFVLTWPMRLKIAYGAAQGLCYMHHDCSPPILHRDVKSSNILLDSGFDAKIADFGLAKLLVKKDEPVTMSGVAGSFGYIAPEYAYTTKVNEKTDVYSFGVVLLELVTGREPNGGDEHTSLVEWAWKHYGEGKPIADAIDEEIREQRYLEVMTTVLRLGLVCTNSIPNCRPSMKEILQILHRCTPLEDNGGLKAGCDIAPLLGSAKYLSSYKCRSKKIVNEDDDSFSCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKV0</accession>
    <name>A0A068UKV0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028079001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKV0"/>
    <dbReference type="FunCoup" id="A0A068UKV0">
        <property type="interactions" value="1341"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKV0"/>
    <dbReference type="MEROPS" id="C48.A03"/>
    <dbReference type="Gramene" id="CDP08937">
        <property type="protein sequence ID" value="CDP08937"/>
        <property type="gene ID" value="GSCOC_T00028079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKV0"/>
    <dbReference type="OMA" id="GFYFEYL"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKV0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="239" mass="27328" checksum="B77680682FF177B4" modified="2014-10-01" version="1">MALMAVAVLCRSLHFDLAKGMADEKVLSYNDVVLRQADLDILSGPHFLNDRIIEFYLSYLSSRRAAEDILFVPPSIAFWIKECPDTASLEEFLKPLNLPNRELVLFPINDNIDVSFAEGGNHWSLLAFRRSAKVFIHHDSSSSCMNSSHASRLYRAIFPYISDGVTYMECSNTPKQVNGHDCGLYVIAFARAICNWYEHTTPKDKKRWWFSDLEHITPSAISELRSEILELIRSLMVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL12</accession>
    <name>A0A068UL12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar cation/proton exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00028412001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL12"/>
    <dbReference type="STRING" id="49390.A0A068UL12"/>
    <dbReference type="Gramene" id="CDP09185">
        <property type="protein sequence ID" value="CDP09185"/>
        <property type="gene ID" value="GSCOC_T00028412001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL12"/>
    <dbReference type="OMA" id="SWGISVT"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000008">
        <property type="entry name" value="Vacuolar cation/proton exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF42">
        <property type="entry name" value="VACUOLAR CATION_PROTON EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="8 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="41"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="229"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP09185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="385" mass="42193" checksum="D664191DB4071DEE" modified="2014-10-01" version="1">MFKQFLNNLRLVFLGTKLCVLIPAIPLAILGQCYGFMTRQWIFALSLLGLAPLAERMSFLTEQIAYFTGPTVGGLLNATCGNATELILALFALRERKILVLKYSLLGSVLSNLLLVLGSSLFLGGLANLKMEQTFDRKQADVNSLLLLLGLLCHVLPLIFGTSIEPQLLDDMDQNSVVWLSRTSGILMLVAYGAYLFFQLRTHRQFFEAEGEDEDELSENEAVIGFWSAFIWLVAMTIIVAILSEYVVGTIEAASDSWKISVSFISLILLPIVGNAAEHAGSVIFALKNKLDITLGVALGSATQISMFVVPVSVIVAWTMGIPMDLDFGLLETSCLGFSIILTAFTLQDGNSHYIKGVVLCLSYAVIAACFFFHKMPASESLYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULF3</accession>
    <name>A0A068ULF3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00028699001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULF3"/>
    <dbReference type="FunCoup" id="A0A068ULF3">
        <property type="interactions" value="1522"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULF3"/>
    <dbReference type="Gramene" id="CDP09365">
        <property type="protein sequence ID" value="CDP09365"/>
        <property type="gene ID" value="GSCOC_T00028699001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULF3"/>
    <dbReference type="OMA" id="MYMRPFQ"/>
    <dbReference type="OrthoDB" id="1932324at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000004">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000009">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF16">
        <property type="entry name" value="OS02G0689700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="189" mass="21168" checksum="CBAC1AE38B8FD120" modified="2014-10-01" version="1">MSALISSKPTLSFTLASQFISTGKENPASLSWSSSLPKLNLSITTTSPSSPLNLLHKQTFVVEAAWTRRSRSEAAKKPNRKSWKQRTDMYMRPFLLNVFFSKRFIHAKVMHRGTSKVISVATTNAKDLRNTLPSLTDNNACRVIGKLIAERSKEADVFAIAYEPDKNQRIEGRLAIILDTIQENGIIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULU1</accession>
    <name>A0A068ULU1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific lipid-transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00028798001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULU1"/>
    <dbReference type="STRING" id="49390.A0A068ULU1"/>
    <dbReference type="Gramene" id="CDP09436">
        <property type="protein sequence ID" value="CDP09436"/>
        <property type="gene ID" value="GSCOC_T00028798001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULU1"/>
    <dbReference type="OMA" id="ADHYQNI"/>
    <dbReference type="OrthoDB" id="649864at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULU1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01960">
        <property type="entry name" value="nsLTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000528">
        <property type="entry name" value="Plant_nsLTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33076">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00382">
        <property type="entry name" value="LIPIDTRNSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654993" description="Non-specific lipid-transfer protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP09436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="116" mass="12424" checksum="57922C910270CA90" modified="2014-10-01" version="1">MKGIACSVLFMVASVLIMVQAGRAMSRLTCGQVDTLLAPCIPYLTHGGEPGPECCNGVRSTKALAQNREDKRQVCICVKEAANRYANLEDDAVQALPVKCGVDVDIPVSRKINCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM13</accession>
    <name>A0A068UM13_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00027678001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM13"/>
    <dbReference type="FunCoup" id="A0A068UM13">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP08643">
        <property type="protein sequence ID" value="CDP08643"/>
        <property type="gene ID" value="GSCOC_T00027678001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM13"/>
    <dbReference type="OMA" id="YKLRMAG"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM13"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000333">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000184">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF540">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40961" checksum="77538E997984BD7E" modified="2014-10-01" version="1">MPTRDVPTWNALIAGYAKSGDMREASRFFSNMPSRNVISWTAMISGYSQNGEYADALALYLEMEKEKGVKPNQVTIASVLPACANLGALEVGQRIEAYAKSNGYLNNMFVCNAILEMYARCGRIDSAMRLFHEIGRRRDLCSWNTMIMGLAIHGKCCEALDLFNQMLGEGISPDDVTFVGAILACTHGGMVAKGRELFESMEQKFSVTPRLEHYGCMVDLLGRAGELQEAYHLIRSMPMRPDSVIWGTMLGACSFYGNVELGEKAAESLFELEPCNPGNYVILSNIYASAGRWDGVAKLRKLMKSSQVTKAAGYSFMEEGGQLHRFIVDDRSHPNCGQIYALLDDVHVKIKLLGYTTDIDSITEETDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNW8</accession>
    <name>A0A068UNW8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030819001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNW8"/>
    <dbReference type="STRING" id="49390.A0A068UNW8"/>
    <dbReference type="Gramene" id="CDP10185">
        <property type="protein sequence ID" value="CDP10185"/>
        <property type="gene ID" value="GSCOC_T00030819001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNW8"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNW8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02879">
        <property type="entry name" value="GH18_plant_chitinase_class_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF396">
        <property type="entry name" value="NOD FACTOR HYDROLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="55"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="44365" checksum="A20FF3DAA9AB459A" modified="2014-10-01" version="1">MAQAQEVELKISQKQNKMVLAPMKAASSSIFCTCLLFMIISFSSSYASPSYSSEAMKGAYYPSWKVAEFPPSAIDTTLFTHIYYAFLNPNASTFKFDIDASTANLLIGFTSTLHSKNPPVKTLLSIGGGGAGPTTFSRMASTPASRRSFILSTIEVARKYGFDGFDLDWEFPQNAQEMNDLGSLFDEWRAEIVKESKATQRPQLLLSAAVYFSSTFFLSATPRTYPIASINKNLDWINAMCYDYHGSWEPTITGSNSALFDPKSNISTSYGLGSWIKAGILRSKLVMGLPLYGRTWTLKDPSVHGVGAPAVGVGPEGDGGSGILLYYEVEEFNKKNNATVGFDVATASTYSFAGTAWVGYDDGRSTAARVGYAQALRIRGYFFWALSFDLDWKISRTASELWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQD8</accession>
    <name>A0A068UQD8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00031282001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQD8"/>
    <dbReference type="FunCoup" id="A0A068UQD8">
        <property type="interactions" value="2882"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQD8"/>
    <dbReference type="Gramene" id="CDP10527">
        <property type="protein sequence ID" value="CDP10527"/>
        <property type="gene ID" value="GSCOC_T00031282001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQD8"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000043">
        <property type="entry name" value="MIF4G domain-containing protein / MA3 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="683"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="882" mass="99279" checksum="216ACCF6D80B02A0" modified="2014-10-01" version="1">MIREAIASQKTSGEKSRRERRKEARLAKNKKKFDSWVQHKQSSKSRKASLDLKPTCGRKLENDNEHSQNKDNILMVSDAGMDGDFEAPSVARKKIGKSRNSKTKFSEYLQMETGSSGMSAEKDLILERKLAKKLKVKNGKLGGLDDEINLLLDGIPSIFDSIKGADREIKSLENGGALFKPDKWNMSEEVVESEIEYGTEEIENETESVSEEISQSNSEEEDNALELIPSKDSRKEKKRTRKTKFEEYLGMEEMQKGALSANEDVEFERKLSKKLKVKDGKLRGDDDGMNNLFEGISSALDYSADVVSQGNRAKVLDNSSLSNRSGMMKSAKQEQAKSMIGMSLEASERVKNDGLDVVAERVPTASHALGLNTKYVAPHLRSRVQDESEEYAQIRRCVRGLLNRLSESNVESITGEVSTIVQSVGRSVGSQIIIEEVLESCSGGPRGNEQYAATFAAFSAGMACLVGIDFGAKLLASLAKCFEMEYLEEDNVSLRNLTLLLSYLYIFGVCTSDLVYDFMIMLSKRLTEVDVSTILTILQSCGMKVRADDPVGMKTFIQSVQQRANELKASSGNGQSNMSGKRMEFMLETLCDIKNNKKRPKEETVQHTRVKKWLQKVRVGDILIGGLKWSKLLDPEKKGQWWLSGDIGSTSDKIEDVASKIDREAPEAQRMLQLAAAQRMNTDARRAIFCVIMSGEDFRDAFAKLLSLDLHGKQDREIIRVLLECCLQEKVFNKYYTVLAHKLCKHDKNHKFTLQYCLWDHFKELETMPLIRSMHLAKFTAQMVASYSLSLAVLKAVDLSDAVELTPKRIMHFRMLFEAIFEFSDALVWNAFSRIAGTSEYESLRTGIKFFVSKYVISSRKPLEQKFKIAKKALKNVKGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US32</accession>
    <name>A0A068US32_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021654001</name>
        <name evidence="2" type="ORF">GSCOC_T00023766001</name>
        <name evidence="3" type="ORF">GSCOC_T00033152001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068US32"/>
    <dbReference type="STRING" id="49390.A0A068US32"/>
    <dbReference type="Gramene" id="CDO97763">
        <property type="protein sequence ID" value="CDO97763"/>
        <property type="gene ID" value="GSCOC_T00021654001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP06792">
        <property type="protein sequence ID" value="CDP06792"/>
        <property type="gene ID" value="GSCOC_T00023766001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP11112">
        <property type="protein sequence ID" value="CDP11112"/>
        <property type="gene ID" value="GSCOC_T00033152001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US32"/>
    <dbReference type="OMA" id="MYLEWAR"/>
    <dbReference type="OrthoDB" id="1897643at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027949">
        <property type="entry name" value="Chloroplast_duf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33358">
        <property type="entry name" value="F-BOX PROTEIN WITH A DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33358:SF12">
        <property type="entry name" value="F-BOX PROTEIN WITH A DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14476">
        <property type="entry name" value="Chloroplast_duf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO97763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="193" mass="21156" checksum="56C7AB5D3BA5E6F1" modified="2014-10-01" version="1">MLEKFPATVEPAVWWPQQAKESAHKTCLKSNGWNSKLEKEMRSIVEVIRRKDKADYLRLGGKALTLNKLLAISGPLLTGLAAISSAFMGSSSHTGFLAAMLGIVGGSLASIVNTLEHGGQVGMVFEMYRSNAGFFKLMEESIESNLMERRENGELFEMKVALQLGRRVSELRDLASSPKSKGEGAEEFASKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USA0</accession>
    <name>A0A068USA0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033237001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USA0"/>
    <dbReference type="STRING" id="49390.A0A068USA0"/>
    <dbReference type="Gramene" id="CDP11167">
        <property type="protein sequence ID" value="CDP11167"/>
        <property type="gene ID" value="GSCOC_T00033237001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USA0"/>
    <dbReference type="OMA" id="FPNDVFI"/>
    <dbReference type="OrthoDB" id="1927690at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USA0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36037">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE (REVERSE TRANSCRIPTASE)-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36037:SF1">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE (REVERSE TRANSCRIPTASE)-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="433" mass="49052" checksum="64469D89647CDA3F" modified="2014-10-01" version="1">MEIDSTAISPSSETLDLDSLQSQILELREILRSCNEDYEMGPSEVKELFQDQALEVQSNMDQIMADTSDINSLSLEGLAELSDHLKNELRSVESENAKIENELNELSRRYVEDSCQLESEVEGLSSFLDSIDKQASKIYFRRDGDLQVDYSTNGKDQANRLKACDGSNIEILELSHQIEKSKSTLKSLQDLDYQVKIFEVVEKIEDALSGLKVLEFEGNSIRLSLTTYIPNMDNMICLQKVELSVEPSEQNHELLIEVVDGTLELKNAEIFPNDVYIGEIVDVAKSFRQLYSPLPLLDNMSSLEWFLRRVQDRIVICTLRRFVVKCANKSRHSFEYLDRDEMIVAHMVGGIDAFIRLAQGWPIASAPLNLLTLKSSSNYSKEISLSFLCKVVDVANSLDEHLQHDISSFADGIEEILLQQMRTEGQPGDTMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTE5</accession>
    <name>A0A068UTE5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00033918001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="HG739140">
        <property type="protein sequence ID" value="CDP11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTE5"/>
    <dbReference type="STRING" id="49390.A0A068UTE5"/>
    <dbReference type="Gramene" id="CDP11582">
        <property type="protein sequence ID" value="CDP11582"/>
        <property type="gene ID" value="GSCOC_T00033918001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTE5"/>
    <dbReference type="PhylomeDB" id="A0A068UTE5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF773">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="17111" checksum="CEADBBED218AFC04" modified="2014-10-01" version="1">MQAHTLGRKTWGAAKGEELEAAKKEFIEALKVLEGELGDKPYFGGEEFGYVDVALIPFDSWFHAYETCGNFKIGAQCPKFAAWAKRCMQRERARGKLCPSIARQYTQLQLGTHRKVFHCGSKLEFSCIWDSSLTTTDFSLNSLDLLPWIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVB8</accession>
    <name>A0A068UVB8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033913001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739140">
        <property type="protein sequence ID" value="CDP11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVB8"/>
    <dbReference type="Gramene" id="CDP11578">
        <property type="protein sequence ID" value="CDP11578"/>
        <property type="gene ID" value="GSCOC_T00033913001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVB8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="62" mass="7307" checksum="09C315C46DA61D85" modified="2014-10-01" version="1">MIDTLQSRAFLLWKDSLCLIKFNSHLVESKKCSLLLFILEIWDDASGFHFSIHTIFIIWSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWJ3</accession>
    <name>A0A068UWJ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035352001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWJ3"/>
    <dbReference type="Gramene" id="CDP12003">
        <property type="protein sequence ID" value="CDP12003"/>
        <property type="gene ID" value="GSCOC_T00035352001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWJ3"/>
    <dbReference type="OMA" id="FMESLYY"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWJ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016138">
        <property type="term" value="P:glycoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058980">
        <property type="entry name" value="Glyco_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48044:SF29">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26168">
        <property type="entry name" value="Glyco_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="460" mass="52553" checksum="BC7BAC4F06D78946" modified="2014-10-01" version="1">MFPWLAHGHMSPFLELSKRLAKNNFQIYFCSTEINLSFIKKDRNLDEYFSDHSIELVQLDLPRFPELPPHYHTTKNLPPHLNPTLHVAFYMGRTNFQNILNILQPDLLIYDMFQAWASELASMFHIPAVLFLGGGAVFWSWSYFYDIINKGYSGIDGTYPFPAIFLRDYEIKRMAAFLQESKEKVPQEVVLSKTKGFEVSSDIVLLKACREIDGKYIDHLSSSRGKKILAVGPLIELKHDDTKEEEKDENSSHIIEFLNGREESSVVYVCFGSEYFLSEEEREEMAYGLELSNANFVWVVRFPVGHAIALEEALPEGFLERVKDRGVVVDGWAPQAKILEHPSTGGFVSHCGWSSFMESLYYGVPLLALPMLYDQPLQARLAVEIGVGIEILRDEDGRIKRENVAKVIKEVVVEKIELGESVKQKAKELSHKLREEGEGQLHEAVEKLKSLCSKNQSQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWK6</accession>
    <name>A0A068UWK6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase small chain, chloroplastic</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carbamoyl phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00037437001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWK6"/>
    <dbReference type="FunCoup" id="A0A068UWK6">
        <property type="interactions" value="1171"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWK6"/>
    <dbReference type="Gramene" id="CDP12786">
        <property type="protein sequence ID" value="CDP12786"/>
        <property type="gene ID" value="GSCOC_T00037437001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWK6"/>
    <dbReference type="OMA" id="AESEWIF"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000034">
        <property type="entry name" value="carbamoyl-phosphate synthase small chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="423" mass="46341" checksum="828354D9D277815D" modified="2014-10-01" version="1">MDCSLRLIHNSPLSTTAFLPKKVRLFTVKCSSSQGFSSVGLAERPWKVADARLVLEDGSIWRAKSFGASGTQVGEVVFNTSLTGYQEILTDPSYAGQFVLMTNPHIGNTGVNFDDEESVQCFLAGLVIRSLSISTSNWRCAETLSDYLAERNIMGIYDVDTRAITRRLRDDGSLIGVLSTEELKSDEELLEMSRTWDIVGIDLISGVSCKTPYEWVDRTGSEWDFNFSARSKENLHVVAYDFGIKHNILRRLASYGCKITVVPSTWPASDTLKMNPDGVLFSNGPGDPSAVPYAVDTVREIIGKIPVFGICMGHQLLGQALGGKTFKMKFGHHGGNHPVRNMRNGSVEISAQNHNYAVDPASLPSGVEVTHVNLNDGSCAGLAFSQLKLMSLQYHPEASPGPHDSDPVFGEFIQLMKQEKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWR3</accession>
    <name>A0A068UWR3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00037542001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWR3"/>
    <dbReference type="Gramene" id="CDP12866">
        <property type="protein sequence ID" value="CDP12866"/>
        <property type="gene ID" value="GSCOC_T00037542001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWR3"/>
    <dbReference type="OMA" id="MTFFLKW"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWR3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="335" mass="36534" checksum="2FC1A7429A54E723" modified="2014-10-01" version="1">MSLASKDENKKVIDVAAWTFNIVTSVGIIIVNKALMATYGFSFATTLTGLHFATTTLMTIILKSLGYIQNSHLPLHERIKFVLFANFSIVGMNVSLMWNSVGFYQIAKLTMIPVSCLLEVVLDNVRYSRDTKLSIMLVLLGVAICTVTDVSVNAKGFIAASIAVWSTSLQQYYVHSLQQKYSLGSFNLLGHTAPLQAASLLLCGPFVDYWLTGKRVDGFNYTLASLLFIALSCTIAIGTNLSQFICIGRFTAVSFQVLGHMKTVLVLVLGFLFFGKEGLNLHVVLGMIIAILGMIWYGNVSSLPGGKERVPPPAADNDPEELSSLVESGQLNEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXB3</accession>
    <name>A0A068UXB3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00038014001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXB3"/>
    <dbReference type="Gramene" id="CDP13165">
        <property type="protein sequence ID" value="CDP13165"/>
        <property type="gene ID" value="GSCOC_T00038014001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXB3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="98" mass="10958" checksum="88E37DFC034C81F0" modified="2014-10-01" version="1">MKAIKLTPPSILVGCSSLHVILHSKININLDNSLLLSFVMKSYDPLLNQTLFQSDQMKTSGMEFPFALCLGWPKPEIFLVCLVLLNCPTDSAICRYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXJ1</accession>
    <name>A0A068UXJ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter B family member 26, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00038089001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXJ1"/>
    <dbReference type="FunCoup" id="A0A068UXJ1">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXJ1"/>
    <dbReference type="Gramene" id="CDP13220">
        <property type="protein sequence ID" value="CDP13220"/>
        <property type="gene ID" value="GSCOC_T00038089001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXJ1"/>
    <dbReference type="OMA" id="CRLYEPQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXJ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18572">
        <property type="entry name" value="ABC_6TM_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000059">
        <property type="entry name" value="ABC transporter B family member 26, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="153"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="469"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79569" checksum="87B3DF3BF2999CBE" modified="2014-10-01" version="1">MALPLVFCHPQTSSSFIISSSQRRTQVLLMRNTNHDPLPIARTNLQLTPSKSNGRFISISPPKSSASVNGYSVNSTISNPEDVDFPTTEGSEKLSQNPRTVIEFIKDILPGGSWWRLSSSDHVEVVLTAKPVTVVRALRRMWDLISEDRWVIFTAFSSLMLTALSQISIPHYLTASIFSAQSNNVSVFSWNVKLLILLCITSGICSGIRGCCFGIANMILVKRMRERLYSTLLLQDISFFDYETVGDLTSRLGSDCQQVSRVIGYDLNLVSRNLLQGTGALIYLLILSWPLGLCTFAICAMLSTIMLLYGQYQKKAAKLIQDYGASANEVAQETLSLMRTVRVYGTEQQELGRYNNWLEKLADISLRQSAAYGLWNFSFNTLYHSTQVIAVLIGGMFILTGRITAEQLTKFILYSEWLIYSTWSVGDSLSSLMQSIGASEKVFQLMDLPPSNQFISTAGSKLQRLVGHIEFLNVTFSYPSRALVPVLQHINFQVHPNEVVAIVGLSGSGKSTLVNLLLRLYEPTGGQIMIDGHPIKDLNTKWLRERIGYVGQEPRLLRTDISSNIRYGCPRVVNQKDVERAAKQASAHEFISSLPNGYQTLVDDELLSGGQKQRIAIARAVLRDPDILILDEATSALDAESEHNIKGVLRAVRSDLKTKRTVIVIAHRLSTIRVADKIVVMEGGKIVQLGSHSELLLKDGLYSRLTRRQADAVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXL6</accession>
    <name>A0A068UXL6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00038135001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="2">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 20S core complex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXL6"/>
    <dbReference type="FunCoup" id="A0A068UXL6">
        <property type="interactions" value="3498"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXL6"/>
    <dbReference type="Gramene" id="CDP13255">
        <property type="protein sequence ID" value="CDP13255"/>
        <property type="gene ID" value="GSCOC_T00038135001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXL6"/>
    <dbReference type="OMA" id="DHIYCCG"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXL6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="273" mass="29433" checksum="63041D4E62262E96" modified="2014-10-01" version="1">MSKAAIEGPPKGGFSFDLCRRNEMLVQKGLNAPSFLKTGTTIVGLVFQDGVILGADTRATEGPIVADKNCEKIHYIAPNIYCCGAGTAADTEAVTDMVSSQLTLHRHHTGRESRVVTALTLLKSHLFSYQGYVSAALVLGGVDFTGPHLHTIYPHGSTDTLPFATMGSGSLAAMAVFESKYREGLTRDEGVQLVAEAISSGIFNDLGSGSNVDICVLTKGHKEYLRNHLQPNPRTYISEKGYSFSKKTEVLLTKITPLRDSIHIIEGGDEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY59</accession>
    <name>A0A068UY59_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038263001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY59"/>
    <dbReference type="STRING" id="49390.A0A068UY59"/>
    <dbReference type="Gramene" id="CDP13356">
        <property type="protein sequence ID" value="CDP13356"/>
        <property type="gene ID" value="GSCOC_T00038263001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY59"/>
    <dbReference type="OMA" id="RHRCVEF"/>
    <dbReference type="OrthoDB" id="652307at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY59"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021775">
        <property type="entry name" value="DUF3339"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33128">
        <property type="entry name" value="OS05G0103400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33128:SF55">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11820">
        <property type="entry name" value="DUF3339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655361" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7596" checksum="52E3B760739AFAEE" modified="2014-10-01" version="1">MSDWGPIFVAVVLFVLLSPGLLFQIPGHHRCVEFGNLQTSGAAIMVHSLLYFALISVFLLAIKLHLYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYE5</accession>
    <name>A0A068UYE5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00038397001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYE5"/>
    <dbReference type="FunCoup" id="A0A068UYE5">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13446">
        <property type="protein sequence ID" value="CDP13446"/>
        <property type="gene ID" value="GSCOC_T00038397001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYE5"/>
    <dbReference type="OMA" id="FDEMRCE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYE5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63810" checksum="274A85C0754B5CE1" modified="2014-10-01" version="1">MATVANSHLSKRLSPLVPESRWLVNTLTSILQKTVNPETELPDILNQFSPHLTPKLVIQVINNQTSPNHSLYFFNWAANLNPNPSNYFHTHHCYIAIADKLISHRLFSLATRLLESHDRYSDFMVGKFIKAHGDLGHLNWAVKLFHHVKEREFGDCLFSYNAVLGVLVKAKRVNLAWGFFGMMIKEAVVKPDVSTYTTMIRGFCQIGMIEHAEKVFDEMSRMGCERNLFTYNTIVHGFCKKGLMENARSIVDKMVESRVYLPDMVTFTTLIDGFCRIGNTDEAMRWFDEMGKRNVMPNVSTYNALINGLCLNGMVDEAKKMQTRMRLSGVKDNVTTHTSLLKGYCSAGRSNEAIQHFREMVGSGLELDQKSYAVIVNEHCKLKMPDKAIALLREMRVKGISPPMYGYNAVLRSLVELGELDKAVFLLKQMPQMGCHPNFLSYSAVICGLVRATGRMQDVWMLVNNMLQDGNRLDTTLYNCLIWGFCEDGNVEMAMNFFLKMIDERYLINLECFEVFVKKLVAEGKLFEIEKLFEQMRKCCPMKEIHSYQKVLDEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V093</accession>
    <name>A0A068V093_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plant bHLH transcription factor ACT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039085001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068V093">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V093"/>
    <dbReference type="Gramene" id="CDP13939">
        <property type="protein sequence ID" value="CDP13939"/>
        <property type="gene ID" value="GSCOC_T00039085001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V093"/>
    <dbReference type="OMA" id="HAMGLEN"/>
    <dbReference type="OrthoDB" id="1917523at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V093"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051358">
        <property type="entry name" value="TF_AMS/ICE1/BHLH6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plant bHLH transcription factor ACT-like" evidence="6">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="158" mass="17519" checksum="3BE7E13E5537344D" modified="2014-10-01" version="1">MVPRGHKRANLHEKLQLLRSLTNSHAMNKTSIIVDASNYIEELKQKVERLKEDISSARSSSDESSSWPKVSVKTLEKGILVNVYSGKSCPGLLVSILEAFENLGLNVLEARVSCADSFHLQAVGGENEDNEEIIDAQVVKRAVADAIRNWEESDTNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1M0</accession>
    <name>A0A068V1M0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">V-type proton ATPase subunit e1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00038820001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1M0"/>
    <dbReference type="FunCoup" id="A0A068V1M0">
        <property type="interactions" value="1836"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1M0"/>
    <dbReference type="Gramene" id="CDP13768">
        <property type="protein sequence ID" value="CDP13768"/>
        <property type="gene ID" value="GSCOC_T00038820001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1M0"/>
    <dbReference type="OMA" id="FCARICC"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1M0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658453" description="V-type proton ATPase subunit e1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7568" checksum="F46796324ABE900F" modified="2014-10-01" version="1">MGFFVTTLIFVAIGVIASLCARICCNRGPSANLLHLTLIITATVCCWLMWAIVYIAQMKPLIVPILSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3B3</accession>
    <name>A0A068V3B3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00042524001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP14999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3B3"/>
    <dbReference type="STRING" id="49390.A0A068V3B3"/>
    <dbReference type="Gramene" id="CDP14999">
        <property type="protein sequence ID" value="CDP14999"/>
        <property type="gene ID" value="GSCOC_T00042524001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3B3"/>
    <dbReference type="OMA" id="PNIRTKM"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3B3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF159">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP14999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22676" checksum="3EFBA16A60FEFDAF" modified="2014-10-01" version="1">MCFVCCICSPTFVKICKGKSVAEFKPDPYVMTLLKCAMWVFYGLPFVKSHSILVSTINGIGFVTEAMYVTLFFVHSDWRKRVRMIYNLHVHYFYLHDFSIKRALIVDVGLTLLNGLFIYLFFWVQSNVIKTESVKYLPFYLSLANLLNIGTVWVCYASLKFDYNVVASNAAIFFSFLEIDCLNSGLFSQIYLLTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V540</accession>
    <name>A0A068V540_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00016808001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V540"/>
    <dbReference type="Gramene" id="CDP15900">
        <property type="protein sequence ID" value="CDP15900"/>
        <property type="gene ID" value="GSCOC_T00016808001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V540"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="92" mass="10695" checksum="3A75C96D573801F4" modified="2014-10-01" version="1">MKLLRISLPKWLFIYLFIFSACKFAIKHSSSSIHLESGLFLWPMTLLFSLWQFSLSEQIVAHLTMNQLMRMLDFTMKKLIAGGVSRVSAQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8D9</accession>
    <name>A0A068V8D9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Red chlorophyll catabolite reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00019333001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739221">
        <property type="protein sequence ID" value="CDP16812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8D9"/>
    <dbReference type="FunCoup" id="A0A068V8D9">
        <property type="interactions" value="1284"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8D9"/>
    <dbReference type="Gramene" id="CDP16812">
        <property type="protein sequence ID" value="CDP16812"/>
        <property type="gene ID" value="GSCOC_T00019333001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8D9"/>
    <dbReference type="OMA" id="WVEFPHL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8D9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051743">
        <property type="term" value="F:red chlorophyll catabolite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015996">
        <property type="term" value="P:chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010363">
        <property type="term" value="P:regulation of plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009439">
        <property type="entry name" value="RCC_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34685">
        <property type="entry name" value="RED CHLOROPHYLL CATABOLITE REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34685:SF2">
        <property type="entry name" value="RED CHLOROPHYLL CATABOLITE REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06405">
        <property type="entry name" value="RCC_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35355" checksum="B2AE9A046430CCFA" modified="2014-10-01" version="1">MAVHICTNFLHSTHTVPSSLRPYPANPSSTTVVRTRVSCLSSSSSSPRMDPQTKFMEFPHVSAPIRDLMLGLVSSVETHLGSSLLPCSLPPDVQYYQNPNGNAEGTVFVRSAIPSSPVDFILGSWINCKLPSGGALNIASLSTYLKPSTNAPNFLIEVIQSTPTSLVLILDMPPRKDLVLYPEYLKTFYEDTELDRHRQLLEKLPEVTPYSSPSLYIRALISPTAILVRIEAEAGEITRIDEIIRDNLSPIANEMIEVWLSLCASVDKEVGEAEMAYLEKRDLITKTKTIEIDLGTNIPRLFGQEIADRVLGVLRGVFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8J8</accession>
    <name>A0A068V8J8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00017341001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739203">
        <property type="protein sequence ID" value="CDP16223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8J8"/>
    <dbReference type="STRING" id="49390.A0A068V8J8"/>
    <dbReference type="Gramene" id="CDP16223">
        <property type="protein sequence ID" value="CDP16223"/>
        <property type="gene ID" value="GSCOC_T00017341001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8J8"/>
    <dbReference type="OrthoDB" id="1732566at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8J8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF467">
        <property type="entry name" value="CARBOXYLESTERASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP16223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="107" mass="11861" checksum="6F26BA7D1BD97672" modified="2014-10-01" version="1">MSAPSHSSVMFLPSSGKYLFVLSLYSGFQYGSLVKLFLVVQLEVRFADTKLPLLVYLHDGVFLIKSAFSPTYHAYLNVVVAEASVVAVSINYRLVPEHSLPIAYEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAZ2</accession>
    <name>A0A068VAZ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00010525001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Prevacuolar compartment membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739262">
        <property type="protein sequence ID" value="CDP17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAZ2"/>
    <dbReference type="FunCoup" id="A0A068VAZ2">
        <property type="interactions" value="3028"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAZ2"/>
    <dbReference type="Gramene" id="CDP17742">
        <property type="protein sequence ID" value="CDP17742"/>
        <property type="gene ID" value="GSCOC_T00010525001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAZ2"/>
    <dbReference type="OMA" id="SERFENC"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAZ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="221" mass="24914" checksum="2D5ADD38177C3B9C" modified="2014-10-01" version="1">MSQVFDGYERQYCELSANLSKKCTTATILDGEQKKQKISEVKAGLDDADALIRKMDLEARSLPPSVKASLLAKLREYKTDLNNLKTEVKRISSANSNQAARDELLESGMADAMMVAADQRGRLMMSTERLNKSSDRIRESRKVMLETEDLGVSILQDLHQQRQSLLHAHNTLHGVDDNISRSKKILTNMSRRMSRNKWIIGSIIAALVIAIILILYFKLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBL1</accession>
    <name>A0A068VBL1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00004289001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739296">
        <property type="protein sequence ID" value="CDP18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBL1"/>
    <dbReference type="STRING" id="49390.A0A068VBL1"/>
    <dbReference type="Gramene" id="CDP18116">
        <property type="protein sequence ID" value="CDP18116"/>
        <property type="gene ID" value="GSCOC_T00004289001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBL1"/>
    <dbReference type="OrthoDB" id="651601at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBL1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140566">
        <property type="term" value="F:histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049914">
        <property type="entry name" value="PHD1-3/5-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33304">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33304:SF36">
        <property type="entry name" value="GB|AAF26970.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="36487" checksum="CCD2B4B178ECD9A8" modified="2014-10-01" version="1">MVEIKTFNFVYCALSSFILLFSNFVVVSTFLLCLFLFGSFWLLIHQRNILVLRSSSFADDPGPHEKCCDICGDIGVSDAIQTCPQCKISCEHIYCMRGSVVMLSPKDWCCDDCLLSIKMLSSTSGFMEDLVCRSQFGTASRLHKSSQPNKQPCDLRQNGIDKKIPHGKVKYMHVEEVIMLSSGAKKSNSPVKSKSTCSTKPVSWKNGASALDRTPVKPKAIPAESSIHIVRANPSFVTSKQLKAVRPNNSQLNTVPGQYVPQSFKGLRETGAIQASLKGQMQKEQPKDTFKDKGEIRVGKAITKAVSASSPATCGQASVNLGKIIYHSCSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC36</accession>
    <name>A0A068VC36_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PALE CRESS, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00000697001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DH200</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739232">
        <property type="protein sequence ID" value="CDP17218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC36"/>
    <dbReference type="FunCoup" id="A0A068VC36">
        <property type="interactions" value="799"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VC36"/>
    <dbReference type="Gramene" id="CDP17218">
        <property type="protein sequence ID" value="CDP17218"/>
        <property type="gene ID" value="GSCOC_T00000697001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC36"/>
    <dbReference type="OMA" id="NMHDGFN"/>
    <dbReference type="OrthoDB" id="1933879at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC36"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009501">
        <property type="term" value="C:amyloplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009509">
        <property type="term" value="C:chromoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009513">
        <property type="term" value="C:etioplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009537">
        <property type="term" value="C:proplastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010239">
        <property type="term" value="P:chloroplast mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009965">
        <property type="term" value="P:leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034563">
        <property type="entry name" value="PALE_CRESS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37219">
        <property type="entry name" value="PROTEIN PALE CRESS, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37219:SF1">
        <property type="entry name" value="PROTEIN PALE CRESS, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37095" checksum="D22E96819A734D81" modified="2014-10-01" version="1">MEAAVLRLGGAPTPIFSALPPSTPALCTTLTPVLCPTSLERIRLPPTPAVCRSKNVEEQDLYGLPKEFYDDEWQARQRQKTKEFHQKRREEEEEEERKVEEYREIGLRMKDYPQEELLKAKKLVASFIKSAEEVEEKIEEAAEKGELNEIVLMVIWNRLDLARHDDEKDAVRSLDLLYRRVETEILKREATPAMRLLNDLLNMHDGFDDQDWLKACKKRMFDTFPREDPFTILAPAGFDIDKHEGPLAPAMPVEADNVLLRVDFVREVAALLQEVRSQQTEAQHEEGLDPESVASMLKQHEKQRAIRQVESLLDLAINLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCD7</accession>
    <name>A0A068VCD7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00011780001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant DMP1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739303">
        <property type="protein sequence ID" value="CDP18222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCD7"/>
    <dbReference type="STRING" id="49390.A0A068VCD7"/>
    <dbReference type="Gramene" id="CDP18222">
        <property type="protein sequence ID" value="CDP18222"/>
        <property type="gene ID" value="GSCOC_T00011780001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCD7"/>
    <dbReference type="OMA" id="KNGHIYH"/>
    <dbReference type="OrthoDB" id="525686at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCD7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007770">
        <property type="entry name" value="DMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621">
        <property type="entry name" value="PROTEIN DMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621:SF0">
        <property type="entry name" value="PROTEIN DMP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05078">
        <property type="entry name" value="DUF679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="223" mass="23693" checksum="65AF80294A3B6E46" modified="2014-10-01" version="1">MDVKVETPASPPTSGGDAKTPLLASQKPDSTTTPQTNQNTSIRQAICSTFKGTAYLASRLPAGTVLAFRLLSPILSNQGDCDVAFKTMTAVLLALCALSCFILSFTDSFKDGKGNVFFGFATFKGFYPIDRTVTISPEEAAKKKIGPLDFLHGFLSLLVFASIALLDKNIVDCFYPTPSVEIKEIISVLPVANGVVCSILFVAFPTQRHGIGFGADPDGVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCW6</accession>
    <name>A0A068VCW6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00007241001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739319">
        <property type="protein sequence ID" value="CDP18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCW6"/>
    <dbReference type="FunCoup" id="A0A068VCW6">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCW6"/>
    <dbReference type="Gramene" id="CDP18427">
        <property type="protein sequence ID" value="CDP18427"/>
        <property type="gene ID" value="GSCOC_T00007241001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCW6"/>
    <dbReference type="OMA" id="TNRECEI"/>
    <dbReference type="OrthoDB" id="1109907at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCW6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039218">
        <property type="entry name" value="REM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674:SF62">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="255"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="352" mass="40737" checksum="D094F5F6223F6622" modified="2014-10-01" version="1">MRVSPEKPHFFKPILPGFKNGLKIPVSFSKYLCGERSNYVLLRRGVREWRVKMSGQSLEEGWRKFAVENNLEVGDFVAFKHEGNMVFDVRVFDPSHCEREYPWIHDENEESTPTSRKASSHDDEEPNKPCFVSSIKPYCIKNSILHIPLGFARANNLRNRSCEVILRDPQQKSWQVEMVPKASHVCFKRGWSAFFKANGLKLGDTFKIELVENGKIPVLDFVPCLTSSNKEPHLQRPTPPQPRPFSTSNNDHPNSFVSTIKAYSIKYSILHLPMKFARSTGLIKLNGEMIVRDERRRQWSVRLQQKGKHVLISSGWSKFRTSNGLKEGDTYKFELIKKGQRPLVNFYCKYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDN8</accession>
    <name>A0A068VDN8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 704C1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00003923001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDN8"/>
    <dbReference type="FunCoup" id="A0A068VDN8">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDN8"/>
    <dbReference type="Gramene" id="CDP17798">
        <property type="protein sequence ID" value="CDP17798"/>
        <property type="gene ID" value="GSCOC_T00003923001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDN8"/>
    <dbReference type="OMA" id="FMFEGDD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDN8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP17798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="59767" checksum="38878E977F58F844" modified="2014-10-01" version="1">MDVLYSIFITVLTLTLVLLIPVAALVLKFFIEKFIRNKKYPPVVGTVFHELFYLDRLYDYQTELAKRQPTVRFLGPDQSEIYTTDSRNVEHILKTNFYKYSIGKINQDIVTDLFGEGIFAVDGEKWRQQRKLASFEFSTRVLRDFSCTVFRRNAAKLVAKVGELSQASQVFDIHELLMRCTLDSIFKVGFGVDLNCLEGSGDKVTKFIRAFDDANELIYWRYVDPFWKLKRYLNIGCEASLKQNIKVIYHFVDELIKTKRKLLELRNDFNDREDILSRFLVESRKDPEKMTDQYLRDIILNFMIAGKDATANTLSWFFYMLCENPLIQERVAEQVKDVTGNQCSENSIDDFMASITDEILEKMHYLHATLTETLRLYPAVPLDGRCADADDILPDGSQVKKGDGVYYMSYAMGRMPYIWGEDAEDFRPERWLKNGIFQPESPYKFVAFHAGPRTCLGKDFAYRQMKILSAALLYYYKFRLGDDAGRVTYRTMFTLHIKGGLHIQAITRTGLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEI9</accession>
    <name>A0A068VEI9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Insulin-degrading enzyme-like 1, peroxisomal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00012649001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739461">
        <property type="protein sequence ID" value="CDP19200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEI9"/>
    <dbReference type="STRING" id="49390.A0A068VEI9"/>
    <dbReference type="MEROPS" id="M16.017"/>
    <dbReference type="Gramene" id="CDP19200">
        <property type="protein sequence ID" value="CDP19200"/>
        <property type="gene ID" value="GSCOC_T00012649001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEI9"/>
    <dbReference type="OMA" id="LTMEYSF"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEI9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000028">
        <property type="entry name" value="Insulin-degrading enzyme-like 1 peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF29">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-LIKE 1, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="193"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="378"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="768"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP19200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="111564" checksum="99A5526E948AEF3A" modified="2014-10-01" version="1">MEEETKTLEIVKARSDKREYRRIILKNSLTVLLISDPETDKCAASMDVGVGNYSDPEGLEGLAHFLEHMLFYASEKYPEEDSYSKFITEHGGITNAFTSSEHTNYYFDVNPDSFEEALDRFAQFFIKPLMSPDATTREIKAVDSEYQKNLLSDGWRMSQLEKHLSSKDHPYHKFSTGNWNTLEVRPKEKGLDTRQELLKFYKEYYSANIMHLVLYGKDSLDISQKLVENKFQEILNINRSHVRFIGQPCSPEYLQIFVKAVPITEGHKLRVTWPITPGTLHYKMAPSGYLSHLIGHEGEGSIFYILKKLGWASSLWAGGSDCAHEFAFFQVDIELTDAGHEHCQEIVGLVFKYIDLLQQSGAQKWIFDELSCMGETHFHYQDKIPPIDSILGVSFNMRLYPPEDWLVGALPKKFNSDIIQVLLDELNSNNVRIFWASKKFEGNTDMSEPWYGTSFSVEKITSCQIQQWKESVCEKQLQLPAPNMFIPSDLSLKNILDKAGVPFVLRKSRYSRLWYKPDTAFCFPKAYIKIDFNCPHSRVSPESVVLTCLFSRLVMDYLNEYAYYADVAGLYYGVSNYYEGFQVTLVGYNHKMRILLETIIEGIAKFEVKPDRFSVMKELLIKDYQNLKFQQPYQLAKYYCSLALQYPTFPWKDELEVLHHLEADDLVQFYPLMLSRVFLECFIAGNLEPTEAEKMVQYTEDIFFSGTRPISDALFTSQHLTHRVVKLKKGINYCYATEGLNPSDENSALVHYIQVHQDDSVMNIMLQLFALIAKQPAFHQLRTVEQLGYITSLALRNFSGVYGVQFIVQSTIKGPRHLDSRTKAFLKMFENKLYEMSSHEFKSNVNALIEMKLEKFKNLHEESAFYWCEIASGTLKFDRIEHEVAALKQLTQEQFIDFFNERIKVGAPRKKAVSVFVYGNSHLSEYEADKSELVAPEFLQIEDICSFRRSRPLYGSFKGGLGHMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFB5</accession>
    <name>A0A068VFB5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00005640001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739488">
        <property type="protein sequence ID" value="CDP19277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFB5"/>
    <dbReference type="STRING" id="49390.A0A068VFB5"/>
    <dbReference type="Gramene" id="CDP19277">
        <property type="protein sequence ID" value="CDP19277"/>
        <property type="gene ID" value="GSCOC_T00005640001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFB5"/>
    <dbReference type="OMA" id="CENANTR"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFB5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000445">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF95">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="236"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP19277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="503" mass="55763" checksum="2E4846CF4D32A9A2" modified="2014-10-01" version="1">MLTGPIPKSLQNCSSLVRARFNGNRFQGNLSEMFGIYPSLDFIDLSNNKFYGKLSSNWGKCKMLKTLIVAKNNITGGIPPEIGNLAQLHTLNLSSNYLSGEIPREIGELTQLSELDLSQNFFTGAIPSEFQNLQNLGTLDLSQNNLSGLIPKALAELPGLLHINLSFNNLEGPIPSGRAFVNLTLEEVKGNKGLCGNVTGLPALEDMEVNKGDLFAICTYDGKALYKEIVRSTEEFSETYCIGKGGCGSVYKAQLPSGEVVAVKRLHNIPNVAKDRSFLNEIRALTEIKHRNVVKLFGFCSNAQHSILVYECLERGSLAKILSIEEAAKELDWQKRLNIIKGITHALSYMHHDCSPPIVHRDISSNNILLDPECEAHVSDFGTAKFLRRDSSNWSSLAGTYGYVAPEFAYTLRVNEKCDVYSFGVLTMEVIKGKHPGDLIANLLSSKLEEIKLKDLLDQRLLYPNQQIEKCLISILKLARECLHVDPQCRPTMLIISRLISTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFZ3</accession>
    <name>A0A068VFZ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00003632001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739711">
        <property type="protein sequence ID" value="CDP19710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFZ3"/>
    <dbReference type="SMR" id="A0A068VFZ3"/>
    <dbReference type="STRING" id="49390.A0A068VFZ3"/>
    <dbReference type="Gramene" id="CDP19710">
        <property type="protein sequence ID" value="CDP19710"/>
        <property type="gene ID" value="GSCOC_T00003632001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFZ3"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFZ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658602" description="Flavin-containing monooxygenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP19710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="103" mass="11693" checksum="5BDECAA4FF9221FC" modified="2014-10-01" version="1">MQVVLVTLLFFHLFYKHVFPPQLAPTLSFIGIPNRVSFNIVLLQANWVAGVLSGKVTLPSIDKMLADVEKHYQFLDEIGIHKSQTHSLLLRHGKSWVELFPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG05</accession>
    <name>A0A068VG05_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00002463001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739725">
        <property type="protein sequence ID" value="CDP19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG05"/>
    <dbReference type="STRING" id="49390.A0A068VG05"/>
    <dbReference type="Gramene" id="CDP19730">
        <property type="protein sequence ID" value="CDP19730"/>
        <property type="gene ID" value="GSCOC_T00002463001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG05"/>
    <dbReference type="OMA" id="WINASWP"/>
    <dbReference type="PhylomeDB" id="A0A068VG05"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF585">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="311" mass="33645" checksum="68A62E10A048AF7B" modified="2014-10-01" version="1">MEGPIPNGICSLNNLGFLSLSYNEFCRTVPACLGNITSLRYIYLSSNKFNSAIPSSFGSHGDLLHLDLSSNYLSGSLPSEIGSLKAATLLNVSMNQISGVIPSAIGGPFANFTSKSFMSNERLCGTPQLQVPACRASLSGKRRTKRVLLIVLITLAVSLIVVAIIIPSIPVLHCDLKPNNVLLDENIIAHVGDFGTAKLLGMGESMAQTQTLATLGYMAPKYGSEGLISKKCHINSFGIMLMETFTRRKPTNEILSGDMTLKDWINASWPDAVSEVIHANLMRLEEDLTGMVHGGCQTTKNKIYIKTYSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGV5</accession>
    <name>A0A068VGV5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00006567001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739885">
        <property type="protein sequence ID" value="CDP19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGV5"/>
    <dbReference type="Gramene" id="CDP19951">
        <property type="protein sequence ID" value="CDP19951"/>
        <property type="gene ID" value="GSCOC_T00006567001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGV5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="85" mass="9504" checksum="18ACB71F96B8822E" modified="2014-10-01" version="1">MAGKLVTAKTEEKAKELATEAMKVEVKTKEELKPREQHSAVITIPRFDYNAPLLSSVIPTPDSSSPAPSRGRRVQQKKPCQFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHU2</accession>
    <name>A0A068VHU2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00007955001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May interact with bacterial adhesins thereby protecting the reproductive tissues from microbial attack. Has no oxalate oxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. In the absence of manganese, it forms tetrameric and pentameric forms which show superoxide dismutase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Secreted</location>
            <location evidence="1 15">Extracellular space</location>
            <location evidence="1 15">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740258">
        <property type="protein sequence ID" value="CDP20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHU2"/>
    <dbReference type="Gramene" id="CDP20405">
        <property type="protein sequence ID" value="CDP20405"/>
        <property type="gene ID" value="GSCOC_T00007955001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHU2"/>
    <dbReference type="OMA" id="YEGFIND"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHU2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010497">
        <property type="term" value="P:plasmodesmata-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000025">
        <property type="entry name" value="germin-like protein subfamily 2 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019620876" description="Germin-like protein" evidence="15">
        <location>
            <begin position="28"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="16">
        <location>
            <begin position="73"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="240" mass="26299" checksum="D316FF7DBD884907" modified="2014-10-01" version="1">MAKSFSYLHLLMFFIIVLLSLVMPCYGADPSPLQDYCIADLSSDIYLNGYPCKNPDNVTADDFFYEGFINDTRGFDADGSKASGAHVDYFPAVNTLGVSMIQIQLLKGGVAAPHTHPRATEMLLLMKGKVIAGFITTDNILFYKTMTPKMLVVIPQALVHFVYNVGEGMALLYAGYNSQQPATQYMAHALFNSTPTVPDAVLSRSFRVNDSIVELIKSSLSVPLFPEIMSNTSSGSVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI02</accession>
    <name>A0A068VI02_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00008796001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740205">
        <property type="protein sequence ID" value="CDP20351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI02"/>
    <dbReference type="STRING" id="49390.A0A068VI02"/>
    <dbReference type="Gramene" id="CDP20351">
        <property type="protein sequence ID" value="CDP20351"/>
        <property type="gene ID" value="GSCOC_T00008796001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI02"/>
    <dbReference type="OMA" id="EWIGDMS"/>
    <dbReference type="OrthoDB" id="1600340at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VI02"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF98">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655965" evidence="11">
        <location>
            <begin position="30"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="13">
        <location>
            <begin position="243"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP20351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="553" mass="61374" checksum="15B56FD28CE4E04C" modified="2014-10-01" version="1">MIMGGSTHFSVFLLVAIILLCSSSKTVNATCYGKEKQALMDFKKDLKDPSGRLSSWIHDVDCCKWEGVVCSNRSGHVIQLHLQSAVREIDDFGDEEESPLSGKISHSLQNLTHLRYLDLSLNDFSGIPIPSFFGSLRSLRYLDLSGAGFQGMVPYQLGNLSSLRTLSITCSVYSSDLQVDNRQWLAGLSNLEHLDMSGVDLSLASNWLEVINMIPSLVEIHLSYCQLGLISHQLGRETFVFHANFSSLAVLDLSRNRNLFGHLIPRWIFGLTTLASLDLSMTSFEGPLPRGFRNLTSLKLLDLSDNLLNGSVPDELIHLNNLISLNLGRNQFEGFLDGIWNWSSLASLDLSYNNFATFLPSQLSTLTALISLDLSHNQFRGSIPSSIANISNLQHSSIADNLMEGIVSESHLDNLTALRSFDASGNSLTLKVSVSWTPRAQFEILGLGSWKLGPQFPTWIRSQKILLDLNLSFAGISDTILPWFFNSSFNSMVRVQISLKLLKVYMCIIVIHIQCASNANAYKKTAKIKGQCIQKAKAAMTSRHVRARSKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ57</accession>
    <name>A0A068VJ57_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_1626</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00004861001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740710">
        <property type="protein sequence ID" value="CDP20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ57"/>
    <dbReference type="STRING" id="49390.A0A068VJ57"/>
    <dbReference type="Gramene" id="CDP20721">
        <property type="protein sequence ID" value="CDP20721"/>
        <property type="gene ID" value="GSCOC_T00004861001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ57"/>
    <dbReference type="OMA" id="ANIVNCF"/>
    <dbReference type="PhylomeDB" id="A0A068VJ57"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500:SF567">
        <property type="entry name" value="SUGAR TRANSPORT PROTEIN 12-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="323" mass="36276" checksum="8CDD58C83023D0E5" modified="2014-10-01" version="1">MVEQEVWEETNHLGWCILECFCCPRYYADFGSHSFGHWRWFCQSVSANLFIRDNTIQISWKINVCFQLFITIGIFAANIVNCFTGKYLPHNGWRYSLGGAAVPAIVMGALAIFLPDTPSSQVDRGKVDDAKLLLKKIRGVENVDLEYKDILEACAESKKVKHPWRDLRKKHYRPQLCVSVLIPLFQQFTGINVVMFYALVLFKTLGFGGTASLMSALITGGVNVLATFISVYGTDKWGRRPLFLWGGLHIYCLYVQNLLLIGIEFGWSGLVDQLPNGFAIAIVACICCFVSAFACSWGPLGWLVPSEIFHTRSGLQHRASPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJF3</accession>
    <name>A0A068VJF3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00010616001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        <property type="protein sequence ID" value="CDP20965"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="92" mass="10089" checksum="B63D91FCA9B44FAD" modified="2014-10-01" version="1">MHTRLSPRKSDLEFFFFDFILVYYLSIYLCSIAGQRVVGEPVASGLVLDDSGLWDPDFYTAAKQEPISLSITAGHGKALQAALSTGVLQVFS</sequence>
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    <name>A0A068VJT9_COFCA</name>
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        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_2441</fullName>
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        <lineage>
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            <taxon>Magnoliopsida</taxon>
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            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Pietrella M."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Priyono X."/>
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                <person name="Rouard M."/>
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                <person name="Zhang Q."/>
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                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">cv. DH200-94</strain>
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        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="218"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="218" mass="24504" checksum="83779170BD1D4EBF" modified="2014-10-01" version="1">METATSDAFGSSTAPLTWHDFLERMRHPSAAPFVKDIKSFIVSFMNNAPDGERDSAAVQEFLGNMETAFRAHTLWAGSSEEELESAGEGLEKYVMTKLFPRVFASLPEDVQADDQLYEKIALVQQFIQPENLDIKPTFQNETSWLLAQKELQKINMYKAPRDKLVCILNCCKVISNLLLNASIAAKENPPGADEFLPVLIYVTIKVNLLFLFFSVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL92</accession>
    <name>A0A068VL92_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_4370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00005234001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743454">
        <property type="protein sequence ID" value="CDP21471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL92"/>
    <dbReference type="Gramene" id="CDP21471">
        <property type="protein sequence ID" value="CDP21471"/>
        <property type="gene ID" value="GSCOC_T00005234001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL92"/>
    <dbReference type="OMA" id="GWDANLE"/>
    <dbReference type="PhylomeDB" id="A0A068VL92"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP21471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="346" mass="39001" checksum="EB0EB3A6EA41E4B5" modified="2014-10-01" version="1">MEQILHTKGGEDEESYAKNSTFQVMFMNVNHELNRSIQEFCQANLAEAECIRVADLGCASGPNTLLAVESIIDSINRECHNLNILKLPNIQVFLNDLLSNDFNSIFKLLPSFYQKLEESYGRGSRSCFIAAMPGSFYGRLFPDNSMHFIHSSYSLHWLSQVPSGLVTEEGLPLNKGSIYIGKTSPKSVHDAYLDQFDRDFTNFLSARADELVSGGHLFVTLAPKIDDPVAYNVQDLLGMTMNDMVSEGLIDEKALDTFNLPHYRPSLEEVKTIIEKNRALKIRYLDTIQLRYRSRSLRAISEPIFQAHFGDGIMNDFFTKLAANISQHQGKMKSPINSLVLSLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN59</accession>
    <name>A0A068VN59_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_9581</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00009414001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748665">
        <property type="protein sequence ID" value="CDP22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN59"/>
    <dbReference type="STRING" id="49390.A0A068VN59"/>
    <dbReference type="Gramene" id="CDP22054">
        <property type="protein sequence ID" value="CDP22054"/>
        <property type="gene ID" value="GSCOC_T00009414001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN59"/>
    <dbReference type="PhylomeDB" id="A0A068VN59"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="44" mass="5038" checksum="2BFF2D04881EE388" modified="2014-10-01" version="1" fragment="single">MALNLRQKQTDCILRMLNLNQPRNIFAHSLAYSHLISCCAARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN60</accession>
    <name>A0A068VN60_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_11542</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00006219001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG750626">
        <property type="protein sequence ID" value="CDP22175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN60"/>
    <dbReference type="STRING" id="49390.A0A068VN60"/>
    <dbReference type="Gramene" id="CDP22175">
        <property type="protein sequence ID" value="CDP22175"/>
        <property type="gene ID" value="GSCOC_T00006219001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN60"/>
    <dbReference type="OMA" id="DSFHKCV"/>
    <dbReference type="PhylomeDB" id="A0A068VN60"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF497">
        <property type="entry name" value="OS11G0695000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP22175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="240" mass="25890" checksum="3B6283468BC1555A" modified="2014-10-01" version="1">MLDLPDNHLSGVLPSNMCHGLHNLEEIDLGGNNFSGAIPASISNCSKLTGINLDDNKFSGPIPNSIGNLRRLEILYLVGDNPLNGILPRSIGNLSISVEWLDVRNSGLRGNIPDSIGNLSNLVLLILSDNSLTGSIPTAIWGLQKLQDLDLSNNSLTGLLSRGLCGFLWDLKGLEWVNLSSNLLRGPLAPEMGELKNLTRLDLSNNQFSGKIPSAIWSSENLDHLSLANNSLQRSIPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNL0</accession>
    <name>A0A068VNL0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_13222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00011630001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG752306">
        <property type="protein sequence ID" value="CDP22271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNL0"/>
    <dbReference type="STRING" id="49390.A0A068VNL0"/>
    <dbReference type="Gramene" id="CDP22271">
        <property type="protein sequence ID" value="CDP22271"/>
        <property type="gene ID" value="GSCOC_T00011630001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNL0"/>
    <dbReference type="OMA" id="FGSHCTV"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNL0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656069" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="176" mass="19078" checksum="2335A729CA6BCABC" modified="2014-10-01" version="1">MDIALLLFWSTSILSLSHNAEGSLFSIREATVHDIRIALDHNRLTSRELVEFYLKEIRRLNPVLNGVIEVNPDALHLAHKADQDRKAKKPGSMTGLAGVPILLKDNIATKDKLNTTAGSYALLGSVVPQDAGVVKKLRRAGAIILGKASMTEWAAARSSGMPNGWNARRGQSVVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQK6</accession>
    <name>A0A068VQK6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_8983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00001388001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748067">
        <property type="protein sequence ID" value="CDP22008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQK6"/>
    <dbReference type="STRING" id="49390.A0A068VQK6"/>
    <dbReference type="Gramene" id="CDP22008">
        <property type="protein sequence ID" value="CDP22008"/>
        <property type="gene ID" value="GSCOC_T00001388001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQK6"/>
    <dbReference type="PhylomeDB" id="A0A068VQK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF347">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="20421" checksum="B0376AA8F00021F2" modified="2014-10-01" version="1">MLEQGRQAHALWIKCKISGNLVVNSALMDIYFKCSSLSEGRLVCEKFLDRNFVTWSALTSGYGHHGRVVQVIESFHRMLDEGFNIWIWTSSNAMCRMCHMHWIELLHTMEKNCRAGHWRIFHHSDKSLVLRHMRMYALLKLTLYLRNRAASWSGLNCLNMHMIFGLPYTTLQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKT5</accession>
    <name>A0A068TKT5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00013937001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKT5"/>
    <dbReference type="STRING" id="49390.A0A068TKT5"/>
    <dbReference type="Gramene" id="CDO96801">
        <property type="protein sequence ID" value="CDO96801"/>
        <property type="gene ID" value="GSCOC_T00013937001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKT5"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKT5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF821">
        <property type="entry name" value="ATP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDR1/CTR1/ARMC3-like peptidase-like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="3">
        <location>
            <begin position="437"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="3">
        <location>
            <begin position="552"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO96801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="635" mass="72102" checksum="26E59F34A4912D22" modified="2014-10-01" version="1">MELKWRTDFMVFDFYKSPNLEPHNAKGGLEEVCRQLENHGIQMLCQIKHGSCQSRAILFKVLADSVGIDSKLVVGLPREGVMERTDSYKHMSVTVFLDSVEFLVDLVRVPGKLTPCTSEAIFFSHMIASRESESALNSYDSPMEPCSPICGYRGQVDLECTELEEFLQPSYQSKLEASTSFSGPSMRGVLAQSKAIAERRLNLSHSDPNVTNSFWWLNQKNMIVEPKTATLNTATSRFSRPGRSILGGRRYSFRDYSNDVATSSPKCILRSAGASPTEARRRRRQCISMVPEIGDDIVRLEGIFHLLGFGAVRAMNEALKRNRFPKENLYASSSCSRREKDDNSDLEETVSKLHPDHRGERVMGYNFHEKQMNSQKAISLPSSPRYFTHHASGRCEAKESIRGPDMISTMNKMLEIPKILNKKLFPFEEWNIEFSELTIQTRIGIGFFGEVFHGIWNGIQVAVKVFLEQDLTLENIEDFCTEISILRYFTSNLLCHRGTISVAFRLHFLNMVIQVNYRCIWAPHRPFILLILRDTSAMVSNSQSFSTDLYETPFTEKCDIFSFGVIIWELCTLNKPWHGVPSVQVVDAVANDGKRLDVPDGPLGKLILDCWGEPDERPSCQDILSRLLDYESTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMM9</accession>
    <name>A0A068TMM9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00014507001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMM9"/>
    <dbReference type="FunCoup" id="A0A068TMM9">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO97237">
        <property type="protein sequence ID" value="CDO97237"/>
        <property type="gene ID" value="GSCOC_T00014507001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMM9"/>
    <dbReference type="OMA" id="QKMAWRS"/>
    <dbReference type="OrthoDB" id="1929591at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMM9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043459">
        <property type="entry name" value="NFD6/NOXY2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156">
        <property type="entry name" value="OS02G0230000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33156:SF26">
        <property type="entry name" value="OS12G0592200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO97237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="93" mass="9946" checksum="725FAF899C182671" modified="2014-10-01" version="1">MAAAWRGSISRSLLSTARASTFRSAPALPRVRPPTLSSLRLRPRRLSFAHSRTTGELGCAQSLMPLCNLTAGAQLTSHLTANLRACCELSHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNI1</accession>
    <name>A0A068TNI1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00014884001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNI1"/>
    <dbReference type="FunCoup" id="A0A068TNI1">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNI1"/>
    <dbReference type="Gramene" id="CDO97514">
        <property type="protein sequence ID" value="CDO97514"/>
        <property type="gene ID" value="GSCOC_T00014884001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNI1"/>
    <dbReference type="OMA" id="WKANRRQ"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO97514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="430" mass="49788" checksum="7DD285BC9E5AF22F" modified="2014-10-01" version="1">MAAVEKTEEELRKEIEELHRQQREITERLRDPRGLRRGALSVSAPRNFAPNGGRQRGFVRPADRTDSEDQPPPKKRLSSAVFKVEDGEIVEDASSPAAAKEVANKPADVEQGAGNSAPTLSERKPSNWSRRDASYQKPSRMDFDIPPAEHVPRVLPKNEDPSLVNRNKRMLNQLRGTLEKFRKEDMQLSGSEAYMRRSDSLKRAEQRAREESERLRQQEREQIAEKRRRDLTLRARVAAKAEEKKLDLLFLRWCEHHKKLGNFIRLFLILVQKTKAEPSIYYAFAKPLDEDVQLVEQEKEQMFQEWKAARREELSQYQKQIVEQYVANVEKELERWQNGRKGRKANNEMANLQETMDKELETHRLEHGPKTRKIPGGTSNEEEEDVEDINVGEDDMMDDVLDVDENSRRVDEIASKAETGDGSPQPENKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP72</accession>
    <name>A0A068TP72_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015121001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP72"/>
    <dbReference type="FunCoup" id="A0A068TP72">
        <property type="interactions" value="1447"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO97704">
        <property type="protein sequence ID" value="CDO97704"/>
        <property type="gene ID" value="GSCOC_T00015121001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP72"/>
    <dbReference type="OMA" id="CEWAYLL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF28">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="60111" checksum="8D8F4F7C1E795190" modified="2014-10-01" version="1">MSSTISRKNILLATVNQATSHVIFRNYLCCFSAFCSHSLVRQYHFIRERDFDQGQECIDLKRDFDFHLLMHKINGVNSEDEVFQVLMQDPACDATKITDELINRLLHRLKDDWKSALGVFRWAELHRGYKPLPNLYDKVVDTLGRMKQMEKMCAFVDEMNMAHLVSLSTIAKVMRRFAGAGEWEDAVRIFDELEKFGLQKNTESMNLLFDTLCKEKKVGQAREIFLKLKSHIPPDAHTFNIFIHGWCKINRVEEAHWTIEEMKGHGFRPTVISYSTIIQFYCHQFNFSRVYELLDEMKDQKCTPNVVTFTTIMHSLTKSGALEESLRIIDRMKSVGCKADTLFYNAFLYTLGRAGRISDAIHVFKVEMPQMGVAPSTSTYNTMISMLCQQEREELALEFLRDMEKSTYCKPEVQTYFPLLKACFKGGNKDDRLSMLLDEMSSKHHLSFDLSTYALLVHGLCKVNKPEEAYNYFTKMIAQDITPRYVTCRLLLDELRQNKKHDAATRVEDFMKKMKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSZ7</accession>
    <name>A0A068TSZ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026099001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSZ7"/>
    <dbReference type="FunCoup" id="A0A068TSZ7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSZ7"/>
    <dbReference type="Gramene" id="CDO99079">
        <property type="protein sequence ID" value="CDO99079"/>
        <property type="gene ID" value="GSCOC_T00026099001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSZ7"/>
    <dbReference type="OMA" id="MTWEPFK"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46067">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46067:SF27">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="21058" checksum="206D52651F07C109" modified="2014-10-01" version="1">MAEEPSKLSEGFQESSEVITIRPTELSDVDELMVYLTDDQVSRYCIWDTYTSREQALDYIKNIAIPHPWSKVICIDNRAIGAISVTPNSGNSKCRAELGYVLGQYYWGKGIMTRAVKTVASAIFDEWPYLERLEATVDVNNKASQRVLEKSGFQREGVLRKYKMLKGYSRDVVMFSFLSTDRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTS2</accession>
    <name>A0A068TTS2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00025616001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YTHDF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTS2"/>
    <dbReference type="SMR" id="A0A068TTS2"/>
    <dbReference type="FunCoup" id="A0A068TTS2">
        <property type="interactions" value="1416"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTS2"/>
    <dbReference type="Gramene" id="CDO98718">
        <property type="protein sequence ID" value="CDO98718"/>
        <property type="gene ID" value="GSCOC_T00025616001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTS2"/>
    <dbReference type="OMA" id="DHMERTS"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTS2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF92">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="3">
        <location>
            <begin position="434"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="762" mass="83923" checksum="E575C334834456FB" modified="2014-10-01" version="1">MRAKINCNKLDTKSSKFESGTTTTTATALVQQEVKAVNHGLNLLSSLSLSLSLSLARARSFARGGSLRMEFYSFPEQEYADTYLIQGTELNSQFSSPSLEAMYSEGAPEFIVDQGLYYPTATNYGYICTGFESPGEWDDHRRVFGLDGQDIQYAGSQTETFPFLYYTPTYGYGQYTYNPYIPGAMVGVDGQFLGAQQYYTIPSYENPSSAPAYFPMVVQSRSDLIANNTTDPFLHTTTSTANRADRSGLKQNISSASSALSSNLLGPASSQASSMMMVSDGTKTNATASVRPITHANVTSNRLSRPPSNQILQGGVSQALEHMPPGKAFPSSSQFKVAQPRANGMSSFGSTLHVEPTTDKVQPTFPHGRGPNVTKVRPDALGEQNRGPRVDKPENQLSVKAYTTRAGDADTEGNIIINIDGYNKDDFPLDYTSAKFFVIKSYSEDDVHKSIKYNIWSSTPNGNKKLNSAYEDAQRFANGDSGRCPIFLFFSVNASGQFCGVAEMTGPVDFYKDMDFWQQDKWTGSFPVKWHIIKDVPNPNFRHIILENNDYKPVTNSRDTQEVRFRKGIEMLKVFKTHVSKTSLLDDFMYYENRQKLLQEEKARLLMKKYEHPVLVPVLDPPDKLTSRINFSSKEDDMSYKCNDSNHSDHDTAASVKTAGLDGDTVNDDVVDVADGEASIHDFLKIGTLTITPKQSGSELLGVVTATVANSSLSDVVTVGSVPVRIKETAESPGFLTFGTIQVDPTVLNHDMACYRGKGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU33</accession>
    <name>A0A068TU33_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00029487001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU33"/>
    <dbReference type="FunCoup" id="A0A068TU33">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU33"/>
    <dbReference type="MEROPS" id="C01.A05"/>
    <dbReference type="Gramene" id="CDO99795">
        <property type="protein sequence ID" value="CDO99795"/>
        <property type="gene ID" value="GSCOC_T00029487001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU33"/>
    <dbReference type="OMA" id="RSATPFW"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000057">
        <property type="entry name" value="Cysteine protease RD19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018645377" evidence="9">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="168"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO99795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="397" mass="43813" checksum="64340C18BB3D602B" modified="2014-10-01" version="1">MMMTSGGLMLTCTLAITLLSCALISSTTFQHEIQYRVQDPLMIRQVTDNHHHRHHPGRSSANHRLLGTTTEVHFKSFVEEYEKTYSTHEEYVHRLGIFAKNLIKAAEHQAMDPSAIHGVTQFSDLTEEEFEATYMGLKGGAGVGGTTQLGKDDGDESAAEVMMDVSDLPESFDWREKGAVTEVKTQGRCGSCWAFSTTGAIEGANFIATGKLLSLSEQQLVDCDHMCDLKEKDDCDDGCSGGLMTTAFNYLIEAGGIEEEVTYPYTGKRGECKFNPEKVAVKVRNFTKIPEDESQIAANVVHNGPLAIGLNAVFMQTYIGGVSCPLICDKKRINHGVLLVGYGSRGFSILRLGYNPYWIIKNSWGKRWGEHGYYRLCRGHNMCGMSTMVSAVVTQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUI1</accession>
    <name>A0A068TUI1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00029619001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUI1"/>
    <dbReference type="FunCoup" id="A0A068TUI1">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUI1"/>
    <dbReference type="Gramene" id="CDO99906">
        <property type="protein sequence ID" value="CDO99906"/>
        <property type="gene ID" value="GSCOC_T00029619001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUI1"/>
    <dbReference type="OMA" id="HWWTHSE"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF155">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657330" evidence="7">
        <location>
            <begin position="28"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="9">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="112"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO99906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="383" mass="44902" checksum="3CE7B6109AA8B566" modified="2014-10-01" version="1">MGAKAKISWPLMWLLFLCFFLLNLSDGESSRYEQEELSWLADNDDEINMIQGRHASLRRCDLTSGKWVYDQTYPLYDPSTCPYLTTAVTCQKNGRPDSDYEKWRWKPDGCTIPRFDALEFLGRMRRRRIMLVGDSIMRNQWESLVCLVQSVIPTARKMVTYHGPAMAFQALDYETSIEFCWAPFLVELKKETGGKRILHLDLIEENAKYWRGVDVLVFDSAHWWTHSDQYSSWDFLADGNNAYTTMNPMVAYEKGLTTWAKWIDLNLDPRRSRVFFRSMSPRHNRDNGWKCYNQKEPLQYFSHPHVPPQLPVLRGVLRRMRFPVYLQDITTLSALRRDGHPSVYGRSIGQEEKQHVKGYTSDCSHWCLPGVPDTWNEMLNVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUK5</accession>
    <name>A0A068TUK5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00026042001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUK5"/>
    <dbReference type="FunCoup" id="A0A068TUK5">
        <property type="interactions" value="2362"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUK5"/>
    <dbReference type="Gramene" id="CDO99033">
        <property type="protein sequence ID" value="CDO99033"/>
        <property type="gene ID" value="GSCOC_T00026042001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUK5"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUK5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000004">
        <property type="entry name" value="Chloride channel ClC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000047">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002251">
        <property type="entry name" value="Cl_channel_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01120">
        <property type="entry name" value="CLCHANNELPLT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="12 14" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="706"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO99033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="796" mass="88068" checksum="85D7E1EC7A6A389B" modified="2014-10-01" version="1">MLSNHLQNGMETAKLLWSRLPTSDAEGQDGVGIGHYKKTDGGTVESLDYEVIENYAYREEQALRGKLYMYYSVCVKWFFALLIGIGTGFAAVFINISVENFAGWKYSLTFNIIQKSYFAGCIIYILFNLALVLSSVYIITHFAPAAAGSGIPEIKGYLNGIDTHGILLFRTLVGKIFGSIGSVGGGLALGKEGPLVHTGACIASLLGQGGSTKYHLSSRWLQVFNSERDRRDLVTCGCAAGVAAAFRAPVGGVLFALEEVTSWWRSQLMWRVFFTSAIVAVVVRTAMGWCKSGKCGHFGSGGFIIWDVSDGQEDYSFMELLPMAVIGVIGGLLGALFNQLTLYITNWRRNYLHKKGNHIKIIEVCLISVITSIISFGLPLFRKCTPCPESDLNSGIECPRAPGMYGNYVNFYCSSKMEYNDLATIFFNTQDDAIRNLFSAKTIHEFSAQSLLTFLVMFYALAVVTFGTAVPAGQFVPGIMIGSTYGRLVGMFVVSFYKRLNIEEGTYALLGAASFLGGSMRMTVSLCVIMVEITNNLKLLPLIMLVLLISKAVGDAFNEGFYEEQARIRGIPLLESRPKYQMRSMTAKDACANQKVVYFPRVVKVSDIVSILRSNMHNGFPVIDHTRNGETLVIGLMLRSHLLVLLQSKVDFQHSPLPCDLRGGSLPIRHNLSEFVKPVSSKGISLEDIHLSRDDLEMYIDLAPFVNPSPYIVPEDMSLSKVYNLFRQLGLRHIFVVPRASRVIGMITRKDLLIEEHEHSGAVELQSTSVRGQKHDKRIRKRNTDGEQPLLDGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUM7</accession>
    <name>A0A068TUM7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00029318001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUM7"/>
    <dbReference type="FunCoup" id="A0A068TUM7">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUM7"/>
    <dbReference type="Gramene" id="CDO99659">
        <property type="protein sequence ID" value="CDO99659"/>
        <property type="gene ID" value="GSCOC_T00029318001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUM7"/>
    <dbReference type="OMA" id="ADWGHAM"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUM7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044162">
        <property type="entry name" value="PHOS32/34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31966">
        <property type="entry name" value="OS01G0783500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31966:SF3">
        <property type="entry name" value="OS05G0501700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO99659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="240" mass="26040" checksum="7E0D209C1C1E0F23" modified="2014-10-01" version="1">MASPQKPPAESDRPPAAILHQPASPRFPSGTPTSGANRKIAIAVDLSDESAYAVKWAVQNYLRPGDAVILLHVRPTSVLYGADWGSVDLSVTDEESQQKMEDDFDNLTTTKANDLAQPLVEANIPFKIHIVKDHDMKERLCLEVERLGLSAVIMGSRGFGAARRSTKGRLGSVSDYCVHHCVCPVVVVRYPDEKDGASDVGEGLKKSGELKNLEGLHPVPEEEPIYHDSSDKATDSEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVI3</accession>
    <name>A0A068TVI3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00032118001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVI3"/>
    <dbReference type="Gramene" id="CDP00236">
        <property type="protein sequence ID" value="CDP00236"/>
        <property type="gene ID" value="GSCOC_T00032118001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVI3"/>
    <dbReference type="OMA" id="FAYCERV"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVI3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="503"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1426" mass="162046" checksum="716A19122D64738F" modified="2014-10-01" version="1">MKRSRDDTYTSSQLKRPVMSSRAEPSGQSQLMGGSGAQKLTTNDALAYLKAVKDIFQDRRDKYDEFLEVMKDFKAQRTDTSGVISRVKELFKGHRDLILGFNTFLPKGYEITLPPENEPPPLKKPVEFEEAISFVNKIKTRFQGDDHVYKSFLDILNMYRKENKKITEVYEEVAALFRDHSDLLVEFTHFLPETQAAASARNAQLGRNSSLRRDDRGSPMTMATPMHFDKKPSSAHGDYDPSVDRPDRDPEKVLMRSDKEQRRRFKEEEKRREGRELREQEYDARDLDDGTHHFSHRRKSGLKEDSDGAYYHQGIVDTEHNIVRSKISTTKNSKNLLQTCMQGQALAFREKVKERLLNSDYHREFLRCLHNYSNEIITKSQLENQVANLLEGHPDLMEEFNEFVAHDKTADGCLAAVMSKHNFWLRSLWNDGQISRSVKVEDRVRDREWDREERDKDHSNRERDRSDRGLAFGFKDVAGPRISSYATKDKFLAKPIQELDLSNCERCTPSYRLLPKNYPIPSASHRTEIGAQVLNDHWVSVTSGSEDYSFKHMRKNQYEESLFRCEDDRFELDMLIESVNTTTKRVEDLLDKMNDDSSPICVEDHFTALNLRCIERLYGDHGLDVMDVLRKNAPLALPVILTRLKQKQEEWAKCRSDFNKVWAEIYAKNYHKSLDHRSFYFKQQDTKSLSTKALLAEIREIFDKRSQEDDMLLSTISGRRQPLVPHLKFEYPDPDIHEDLYQLIKYSCGEVCTSEQLDKVMKIWTTFLEPMLGVRSRPQREDTEIVRKASNCSVRTITNTVCGSDGSPPGSASVIACKQSDASKIAEESIPSERSTSRNGGNEVKDDDSHDAAHKSDSLGNASQPAKICNDGIVADEFSQISKLASLGEQLTSSSADGHERANAENASGSCATPGKPGDVTAEIELQMRASNESQNADCTQPESSSAVTAPEGFKIQKFQEESVAHFKMEREEGELSPTGDFEEDNFAECKEVERDAKVNAHKTQHQDVTGGGETCGGDAVGENDADGDDEGEESARRSSEDSENASGNGDVSASESADGEECSPEEPDEDGENDANDNKAESEGEAEGIADAHDVEGDGAILPHSERFLQAAKPLTKLIPPGSPEGDKGYQIFYGNDSFYVLFRLHHILYERIHKAKLHSSSAENKWRVSNDTNPTDSYARFMNALYSLLDGSADNAKFEDDCRAIIGTQSYLLFTLDKLIYKLVKQLQTIATEEMNNKLLQLQAYERSRKPGKFVDCYYNENVHVFLNDENIYRIECSSVPTRLSIQLMDCSFDKPDSNAVSMDPNFAAYLTEFLSVVVPERKVNPGLYLRRNKRKYMHLDENDAFMEASKGLVMRNGLECKINCNTSKVFYVLDTEDLLLRRRKKRRISHENGSCNGHAKSSNGFFNKIWDKLLFSQYAVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW58</accession>
    <name>A0A068TW58_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032506001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW58"/>
    <dbReference type="STRING" id="49390.A0A068TW58"/>
    <dbReference type="Gramene" id="CDP00540">
        <property type="protein sequence ID" value="CDP00540"/>
        <property type="gene ID" value="GSCOC_T00032506001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW58"/>
    <dbReference type="OMA" id="MAXIATS"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW58"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF19">
        <property type="entry name" value="F24J5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="19331" checksum="DE910CED90ECD564" modified="2014-10-01" version="1">MASTTWGFDASVGLNTPNISAFTNHKRHLPITFLSLPPSSRPPPNFVIKSSRSRVCQRKITSKQFLGVPVLSCLVGDNAGVYPESREASNSSHSPQDAAFDIKLPRRSLLVKFTCNLCGSRSEKLVNRLAYERGTVFVQCSGCRQHHKLVDNLGLVVEYDFREEMDSDSNANRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW82</accession>
    <name>A0A068TW82_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029250001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW82"/>
    <dbReference type="FunCoup" id="A0A068TW82">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TW82"/>
    <dbReference type="Gramene" id="CDO99608">
        <property type="protein sequence ID" value="CDO99608"/>
        <property type="gene ID" value="GSCOC_T00029250001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW82"/>
    <dbReference type="OMA" id="CGFKMRQ"/>
    <dbReference type="OrthoDB" id="9985979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW82"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF47">
        <property type="entry name" value="OS07G0564800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46970" checksum="0292B01760C4EC86" modified="2014-10-01" version="1">MRASKPWWWLLKKRLAIFDGGTCGAKMKPLPFMVVICTLMLFVVYRTTNYQYRQTEMESRLRPFFMLKDSGIPTTSLNALPRGIIEARSDLELKPLWSSDSSRKELNTPSSQCLLAIPVGIKQKHNVDRIVQKFLPENFTIVLFHYDGNVDGWWNLEWSKKAIHMVAFNQTKWWFAKRFLHPAVVSAYDYIFLWDEDLGVEHFCPRRYLEIVKAEGLEISQPALDPNSTGIHHRITIRQRSKKFHQRVYETRGSTKCSDASDGPPCAGFVEGMAPVFSRAAWHCSWHLIQSDLVHGWGMDMKLGYCAQGDRTKNVGVVDSEYIVHQSIQTLGGKSAKKTSIAGGSTKRHEVDVRSEVRRQSTSELQTFEDRWERAIKEDRYWVDPYKGSQRRRRRYSRRRHHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY16</accession>
    <name>A0A068TY16_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034725001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY16"/>
    <dbReference type="FunCoup" id="A0A068TY16">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP01175">
        <property type="protein sequence ID" value="CDP01175"/>
        <property type="gene ID" value="GSCOC_T00034725001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY16"/>
    <dbReference type="OMA" id="KEWSNIR"/>
    <dbReference type="OrthoDB" id="509361at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040320">
        <property type="entry name" value="At4g37920-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31755:SF3">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31755">
        <property type="entry name" value="FOLATE RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="433" mass="49536" checksum="8D82F00A69AE3264" modified="2014-10-01" version="1">MELASTSASLGTYIVFPKPQLSFTSRTLYPSLFSVRNSFSKSLYLASKSQVRLHEFFHAAAVGNTSRVPYDSVEEHMTTAKHSGLKASNGITTSKEEETDKKDAAKSLDDQKMTRVCDKLIEVFMVDKPTPTDWRRLLAFSREWDSIRPHFYQRCQDRADTENDPGMKHKLLRLARKLKEVDEDVQRHEELLKVIRKSPSEISEIVAKRRKDFTQEFFVHLHAVAESYYDNPTEQNAVAKLGNMCLAAVQTYDTATESIEALNAAELKFQDIINSPSVDAACRKIDSLAEKNQLDSALVLMITKAWSAAKESTMTKDEVKDVLYHLYMTARGNLQRLVPKEIRILKYLLTIEDPEERMSALKDAFTPGEELEGKDVDCLYTTPEQLHTWIRTVVDAYHFSREGTLIREARDLMSPKIIQKLDELKKLVQDKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYE2</accession>
    <name>A0A068TYE2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00034412001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYE2"/>
    <dbReference type="FunCoup" id="A0A068TYE2">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00949">
        <property type="protein sequence ID" value="CDP00949"/>
        <property type="gene ID" value="GSCOC_T00034412001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYE2"/>
    <dbReference type="OMA" id="WTITIRG"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYE2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="752" mass="84729" checksum="70F491202A6EB1DF" modified="2014-10-01" version="1">MASLEISEDDSTLNAPKHKDHEYDTKDIDPEEESPVEQVRLTVSNHDDPSLPVWTFRMWFLGLLSCVLLSFLNTFFGYRSQPLTITMISAQVATLPLGRFMAKVLPKKKFRIPGFGSRQFSLNPGPFNMKEHALISVFANAGSSFGGGTAYAIDIVTIVRAFYHRRISFLASWILVTTTQQVLGYGWAGIMRRYVVEPAHMWWPSSLVQVSLFRALHEKDKSRMSRGKFFVIALICSFSWYTFPGFLMPMLTNVSLLCLVFPRSITMQQIGSGLSGIGIGSFSLDWSAVASFLGSPLVSPFFATLNAFVGYVVIVYVLIPLAYWKFNLYDGKTYPFFSSQLYDNQGKHYNISAIVTDKFQLDLPEYEKLGPVNMSVIFATTYALSFANLTSTLTHVALFYGKEIKDRFQASSKGKPDIHTKLMRKYKDIPSWWFMVMLSLALALSLVLCTVMIDQVQLPWWGLLFSAGIALFFTLPISIITATTNQQPGLNVITEYVFGYVYPGKPVANVCFKTFGYISMGQAVSFLNDFKLGHYMKIPPRSMFIVQFLGTIIAGTINIGVAWYLLTSIDNICQKDLLPPDSPWTCPGNDVFYSASVIWGLIGPKRMFGPLGRYSALNWAFLAGALAPLLVWLVHKVFPSQKWIKLINFPVLLGATAMMPPARAVNYNAWFVFAFVFNFYVYRYRKKWWQRYNYVLSAALDAGLGFMGVLLYFCLQYGGFYLLWWGSEEDDHCPLVACPTAKGIAVDGCPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYK7</accession>
    <name>A0A068TYK7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3054 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034493001</name>
    </gene>
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            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
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                <person name="Cenci A."/>
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                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
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                <person name="Ming R."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <location>
            <begin position="117"/>
            <end position="137"/>
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    </evidence>
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        <source>
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    </evidence>
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    <sequence length="269" mass="29055" checksum="AF429598C4E5893E" modified="2014-10-01" version="1">MNVLSSQAAGGAAVAAVSCTHRCSLQFTNPVPPLFSNRRPPKFPPANTHNFPRRRTVANAESTTSRPSATPTGPSTPPNSAKEDVPITLVGEQDVPLEGVIQFEKPTSSPSTLISKWGWVALLAGGDALALLLFSAIGRFSHGFDVFDLETLKTADPLMAGWFLSAYFLGGYGEDGRGMNGRSQAITVAAKSWALGIPLGLIIRAATVRHIPPINFILVTMGSTAVLLIGWRALLFSTFYPDKSKKNDVYRRGSPFELFELLTSLVRRW</sequence>
</entry>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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                <person name="Aury J.M."/>
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                <person name="Perrotta G."/>
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                <person name="Bertrand B."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </evidence>
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</entry>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
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                <person name="Giuliano G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
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    </reference>
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        </subcellularLocation>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ERF_plant"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP01664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="219" mass="24656" checksum="CB1195D2E2BAEEB5" modified="2014-10-01" version="1">MAMMQSFNLFNLDMGSASSEFFPFESSFWWDENVFLDDSTTSKTEHESGESKATESIKTGSCKGVSHEEEVTSSLKKKSNKKEKSYIGVRKRPWGKYAAEIRDSTRHGLRVWLGTFDSPEEAAFAYDQAAFSLRGPMASLNFPADRVQESLEGIKHNWENGCSPAAVLKETHKIRSLSKRRRNQKKEINPKKIVLELEDLGADLLEELLSSSSESTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1Q1</accession>
    <name>A0A068U1Q1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00036624001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the GEM family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037848">
        <property type="entry name" value="GEM-like"/>
    </dbReference>
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        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31969">
        <property type="entry name" value="GEM-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="3">
        <location>
            <begin position="214"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="338" mass="37083" checksum="B94E09904571936E" modified="2014-10-01" version="1">MDQPSKDGGGKKEIAEAEERKGSGQGTDPSSNPDAKSSESNEEDRNEKQNLENNASSKSNGIVNENINSNKFDNNDSENNESGGGSGSDKSPSPLNSKLKKSVRWSEDLVSDSPRPRSSTPSYSEERSGSNPYVAYSAAPSDSNLSSIDIKSKMESAKDVLGRWARNVKEATKKAEDLAGNTWQHLKTGPSLADAALGRIAQGTKVLAEGGYEKIFRQTFETVPEEQLQNSFACYLSTSAGPVMGILYVSTAKLAFCSDNPLSYKSDDKTEWSYYKVVIPLHQLKAVNPSSSRNNPSEKYIQIISVDNHEFWFMGFLNYDRAVKCLQEVLQTHQLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1U5</accession>
    <name>A0A068U1U5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00039916001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. AP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068U1U5">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1U5"/>
    <dbReference type="Gramene" id="CDP02515">
        <property type="protein sequence ID" value="CDP02515"/>
        <property type="gene ID" value="GSCOC_T00039916001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1U5"/>
    <dbReference type="OMA" id="NGFHTLM"/>
    <dbReference type="OrthoDB" id="207175at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1U5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010073">
        <property type="term" value="P:meristem maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FLORAL HOMEOTIC PROTEIN APETALA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="228"/>
        </location>
    </feature>
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            <end position="321"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="530" mass="58374" checksum="83A41FC16CFF68B8" modified="2014-10-01" version="1">MWDLNDSPDQTWDDESEGCSSPVDGEDDKGKRVGSVSNSSSSAVVIEDGYSDEEVGELRGGSRKRGTSTSRIFGFAVSAHNDDNCSSESDQPPVTRQFFPVDESDMGVGTSSGGCNEGASSGSGVPDLPRAPWVGVKFCQSEPLGGGVLGKSTEVSQPLKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVEADINFSLADYEDDLKQMSNLTKEEFVHVLRRQSTGFPRGSSKYRGVTLHKCGRWEARMGQFLGKKYVYLGLFDTEIEAARAYDKAAIKCNGKDAVTNFDPSIYEDELNSSESGGGAADHNLDLSLGNSASKLSSSHRGMAPNVDPSKDQHSASMHFQVDWRRHHDHGFRSKQENNPNDVESSRRDGYSEAEAAQLLSQTHLHSPGSMKPKEIQKYGQFRRGGESHIFQMLPPQFNSSNYHFQFPSSSNGGLIGANGDLSLSTSDPHWQYNPPHFYGTAAASSGFPQQIVRPQDWTQKNGFHHHLMRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U205</accession>
    <name>A0A068U205_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040005001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="GSCOC_T00040005001"/>
    </dbReference>
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    <dbReference type="OMA" id="MHVLKRW"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
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        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
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    </dbReference>
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        <property type="entry name" value="MFS_5"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="31"/>
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            <end position="205"/>
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            <end position="236"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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    </feature>
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            <end position="408"/>
        </location>
    </feature>
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            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP02575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50975" checksum="AEC32FD02EE845AA" modified="2014-10-01" version="1">MGVVEESDVWEPNKALYLFTLISCFASIYFCPHYSGRAAPTTVFDHAQSSSAFFRFQRSFLLLFSLSSVMEGLGTVFGEFEWEHYYGGVSKEQMLLYVCAGCAASLFIGTFLGVLSDLMGPRNVCLLFYTLHLLVSIFKSFLTHASLCFTSFCLSLASSIFSFSFEAWMVFEHDKLGQRQDTLNDLFWLMTFIESASFICSQFLGNWLIGGNRDKSILSPYNAAVVLAIICILHVARGFKENPRTASCSDYWISFQTHIFSDKRVWLLSWSQVCVHLSIAVFWVLWAPTIVADGREVQLGLIYPCLMGARMLGSTAVPWLYNGTISLRIEECLIYVLPVMGLLLSVVAYDYQDVGVLLVLFFLFHACVGVVLPSLARLRSMYVPNELRGGMITLSQAPVNMVFLSFLVQRGYYRTVANSTIIAFAALGLFSSAGCMYMLKRPAKQPYQNWHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2E8</accession>
    <name>A0A068U2E8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00040162001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2E8"/>
    <dbReference type="STRING" id="49390.A0A068U2E8"/>
    <dbReference type="Gramene" id="CDP02695">
        <property type="protein sequence ID" value="CDP02695"/>
        <property type="gene ID" value="GSCOC_T00040162001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2E8"/>
    <dbReference type="OMA" id="GMMENNV"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47342">
        <property type="entry name" value="PROTEIN PTST, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47342:SF1">
        <property type="entry name" value="PROTEIN PTST, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="280" mass="31982" checksum="7263C8B792AF1C0E" modified="2014-10-01" version="1">MECQILISTGVRPFLARWNSNKGLKKLVRLNQASIRQNAANKISWKLHCTPASLEEEFSALRSQEFTEDDERDVEDLPDEASPKPLSSEELKALLLDSERSKIIKKLSDANQYNRVLKRQLQSKEDSLVNFKSELAVLELEIQALVSLAEEIANYEIPEGSRKINGRYIQSHLLSRLEAVQEKLREQTKDVDAAQSKEVPLYWYGVAESVQVMGSFDGWSQDEHLSPEYTGSYTKFSTTLMLRPGRRYEIKFLVDGEWNLSPEFPTVGEGLMQNNLLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2S4</accession>
    <name>A0A068U2S4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LOB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039854001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2S4"/>
    <dbReference type="STRING" id="49390.A0A068U2S4"/>
    <dbReference type="Gramene" id="CDP02469">
        <property type="protein sequence ID" value="CDP02469"/>
        <property type="gene ID" value="GSCOC_T00039854001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2S4"/>
    <dbReference type="OMA" id="GQLMIRE"/>
    <dbReference type="OrthoDB" id="772606at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2S4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF68">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="292" mass="32148" checksum="536583B44A9E9D5C" modified="2014-10-01" version="1">MSSSNSPCAACKCLRRKCTQECVFAPYFPPDQPQKFINVHRVFGASNVAKLLNELGTGQREDAVNSLAYEAEYRLRDPVYGCVGLISILQQKLKQVQHDLNNAKKELATYIGPSAMLPIFQHPGFMQQHPNNPSASTVMPYAMQPMMGLPTGVAAPHGGPLIIRDAQQQQQMYEAQQYAAAVAARDQEMFRAYEQQQQQQPPPQELMRFNSGFEGAGPAAATAFNTMSCGAAMSPSLALGSYEAFQLESQLMLQQQQPQQLPLQSHHQPQAAQQQHPQRAKSEEGRSVGPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U364</accession>
    <name>A0A068U364_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00041466001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U364"/>
    <dbReference type="FunCoup" id="A0A068U364">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP03005">
        <property type="protein sequence ID" value="CDP03005"/>
        <property type="gene ID" value="GSCOC_T00041466001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U364"/>
    <dbReference type="OMA" id="AYYAYYK"/>
    <dbReference type="OrthoDB" id="5597044at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U364"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP03005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="103" mass="11287" checksum="7B42E13ED0FAA8BD" modified="2014-10-01" version="1">MAYVDHAFSISDEDIMMDTPYTVNNRPPIKEIALAVALLVFGTLGIVLGVIMAVNKVGGDRAHGLFFAILGGILFLPGFYYTRIAYYAYKGYKGFSFSNIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3E8</accession>
    <name>A0A068U3E8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDSL esterase/lipase 5-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041501001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3E8"/>
    <dbReference type="STRING" id="49390.A0A068U3E8"/>
    <dbReference type="Gramene" id="CDP03031">
        <property type="protein sequence ID" value="CDP03031"/>
        <property type="gene ID" value="GSCOC_T00041501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3E8"/>
    <dbReference type="OMA" id="VNACCGT"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044552">
        <property type="entry name" value="GLIP1-5/GLL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966:SF13">
        <property type="entry name" value="GDSL ESTERASE_LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654532" description="GDSL esterase/lipase 5-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42740" checksum="755DC2EF32EDF23D" modified="2014-10-01" version="1">MRLNSRFGTSSLIHVSLVLLLCFKASGGSAERSSAFFIFGDSTVDPGNNNYIKTTPENQANYKPYGQNGFFKEPTGRFSDGRIIVDYIAEYAKLPIIPPYLQPSADYSHGVNFASGGAGILSTTNPGVVIDLKTQLEYFHKVQRSLAEKLGTAEAEEIISNAVYFISMGSNDYMGGYLGNPEMQQLHPPEDYVRMVIGNLTQGIQELYDRGARKFGFLSLCPLGCLPALRVLNPKGHDAGCFEQASALALAHSNALQAVLPNLELLLPKGFKYCNSNFYDWLLDRINDPTKYGFKEGESACCGAGPYRGIFTCGGTKKDPNYELCDNPSDYVWFDSFHPTERIHEQFAKALWDGLSPSVGPYNLEGLFFNKQTIADVVDNPETQQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3G8</accession>
    <name>A0A068U3G8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041534001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3G8"/>
    <dbReference type="FunCoup" id="A0A068U3G8">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3G8"/>
    <dbReference type="Gramene" id="CDP03056">
        <property type="protein sequence ID" value="CDP03056"/>
        <property type="gene ID" value="GSCOC_T00041534001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3G8"/>
    <dbReference type="OMA" id="MVNSEKC"/>
    <dbReference type="OrthoDB" id="418615at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3G8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF29">
        <property type="entry name" value="POLLEN RECEPTOR-LIKE KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657569" description="Protein kinase domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="228"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="503" mass="55548" checksum="8E844ED6CC3D71FA" modified="2014-10-01" version="1">MTAVRRLPSQLLSLFLILFLSPVSTSLKDDEALFGFKDSLRNTAAIDSSWIKGTSPCAAGKTWKGVVCHEETVQTIRLQGIGLSGDIDVEYLSKLENLRSLTLAYNNFSGPIPPFNKLGGLRALFIQGNQFSGSGTKWVILGVVVALLLMTIFFKAKQKEDHFDVLAKENIDDIVEVRVPSSNRRSTSSRRGNDSFHSRKSSHHGKSVGDLVVVNDAKGTFGLQDLMKAAAEVLGNGGLGSAYKALMGNGVSVVVKRMREMNKLSKDAFDSEIRRLGNLRHQNILPPLAYHYRKDEKLLVSEFIPKGSLLYLLHGDRGTSHAELNWPIRLKIIQGVAQGLGFLHSEFASYELPHGNLKSSNILLSSSYEPLLTDYAFFPLISNTQTAQSLFAYKSPEAILYQQLTPKSDVYCLGIIILEILTGKFPSQYLNNQKGGTDLVQWVNSAIAESREVELIDPEIANATGSLAEMEKLLHLGAACTESEPDKRIDLREALRRIEQIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4T8</accession>
    <name>A0A068U4T8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00015984001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4T8"/>
    <dbReference type="STRING" id="49390.A0A068U4T8"/>
    <dbReference type="Gramene" id="CDP03575">
        <property type="protein sequence ID" value="CDP03575"/>
        <property type="gene ID" value="GSCOC_T00015984001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4T8"/>
    <dbReference type="OMA" id="PGPHVFR"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4T8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="462" mass="50180" checksum="D86708C3538351DD" modified="2014-10-01" version="1">MDRLVKPDLQELCLPFARGRRCCATFKLTNLMHTMSVAVSLTTTNPSLFNFSQPFSVIPPLSTSAFTLSLSHTPTAIYSDQPPLSSPLDSVLVRSSMLPTGKAHHDDLRQLFSKPGPHIFRDATLPVSFVGPHVVESLILAPSPKSLEVAFLLSKAILWCDTRQLTSLLRCSARRGNADVASALIEAGADVNDRDEEGQSAMSLAVKSGNTGVVQVLIESGYSMEHSVDLFLHDAAAMNRLDILEILCLGYSDIDMNSTDSRGQTALHLAAHRGHLDVVRFLVSEGSDPDVVDGKGWAPLHYATREAHVEAVEFLLEHSVSAKYAVTKEGKTAFDLAKDEDQTHMYSMLRLGDDLHRAATTEDDVEAIKNCLGQGANVNSRDQNGWTPLHRAAFKGRIESVKVLINHGAEVDQVNDTGYTPLHLAVEAGHMQVALCLLAHGARANLKSLKAELVPSTTILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5N6</accession>
    <name>A0A068U5N6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00016026001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5N6"/>
    <dbReference type="STRING" id="49390.A0A068U5N6"/>
    <dbReference type="Gramene" id="CDP03607">
        <property type="protein sequence ID" value="CDP03607"/>
        <property type="gene ID" value="GSCOC_T00016026001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5N6"/>
    <dbReference type="OMA" id="RHRRMKI"/>
    <dbReference type="OrthoDB" id="1627850at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5N6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11393">
        <property type="entry name" value="bHLH_AtbHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045239">
        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF109">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="292" mass="31789" checksum="06D5935A11C93D1D" modified="2014-10-01" version="1">MEDESNCNAFPFTATTLAFGGRGSSSSNNHNVYYMQEEADHSHYLNFAAAAAASNDTTPHHAPTTLPSWLCCQPTPQNYVHFLAENGASQVHNEILPFNNSPGSSGFTTPEASFDMVGYKRPHTEGVPPSNLTVLGFQIPSQNSNESYGTAVTGSPSTVPSSTSRQKAATADRRRRLRISEGVEALQELLPHPREGGKASVLDDIIDHIKYLQFQVKELSQSRLGGESSSTPFILLEGYGHFLLRDQMQNEPLEEMMGRLLEVNPLAATQLLESGGLIVMPMSLAEGLRPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U666</accession>
    <name>A0A068U666_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00041587001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U666"/>
    <dbReference type="STRING" id="49390.A0A068U666"/>
    <dbReference type="Gramene" id="CDP03103">
        <property type="protein sequence ID" value="CDP03103"/>
        <property type="gene ID" value="GSCOC_T00041587001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U666"/>
    <dbReference type="OMA" id="PAKMNRD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U666"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF94">
        <property type="entry name" value="CYTOCHROME P450 72C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP03103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57090" checksum="986387FA524E5DBE" modified="2014-10-01" version="1">MEDLKILSLKVASLLLASYFFLKVFYSIWWKPKWFERHLKQQGIEGHPYKLLIGHMKDFMNQITEAWSKPMSQPLSSDCTTRRSLHSQHSSKIWEDITMLGRDNSKVEHYGSRDNKRKGLTLLEGEIWATHRKIMTPAFKLEKLKGMVSIFAEGCVLLVEKWKKSIALGGTSEIDVWPDFQELTGDIISRTAFGSNFDEGNQILKLQIELQSLLKPCKARTYLVLGTLPFIPTKKSQRRKSLDKNITSMLRTLIERKRTLMRTGQTNTDDLLGLLLQSNDENSLQSSPYNKDGNKMTIKEIIEECKQFYIAGRETSSSLLTWTMVILAMHPEWQEKAREEVLTVCGKEHPDAKTISQLKSVTMILHEVLRLYPPTIALYKHTYQEIKIGNLSLPAGVDLTLPLLLTHRDPELWGSDAEEFKPERFSGGLSKASKNQLAFFPFGWGPKTCIGQHFALMEAKVALSIILQNFSFELSPSYAHAPNTVMALQPQHGAPIILKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8H1</accession>
    <name>A0A068U8H1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00019588001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8H1"/>
    <dbReference type="STRING" id="49390.A0A068U8H1"/>
    <dbReference type="Gramene" id="CDP04840">
        <property type="protein sequence ID" value="CDP04840"/>
        <property type="gene ID" value="GSCOC_T00019588001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8H1"/>
    <dbReference type="OMA" id="KMISIMD"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8H1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093:SF2">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="515" mass="57759" checksum="155ACF9DA33A2423" modified="2014-10-01" version="1">MSQNNWEADKMLDVYIHDYLVKRDLKATAQAFQAEGKVSSDPVAIDAPGGFLFEWWSVFWDIFIARTNEKHSEIAASYIETQIIKAREQQQHQQQQQPQSQHPQHPQQQQQQQLQMQQLLLQRQAQQQQQQQQQQQQQQQQQQQQQHQQQQQQQQHQQQQQQQQQMQHQQQQRRDGGHLLNGSANGIAGNDPLMRQNPGTANALATKMYEEKLKLPVQRDSLDDPGMKHVSPLLDPNHASILKSAAAAGQPSGQVLHGTAGGMSPQVQARSQQIPGSTPDIKTEMNPILNHRAAGPEGSLIGIPGSNQGGNNLTLKGWPLTGLEQLRTGLIQQQKSFMQGSQPFHQLQMLTPQHQQQLMLAQQNLTSPSASDESRRLRMLLNNRNMTMSKDGLSNSVGDVVPNLGSPLQAGCPVMPRADPDMVLKLKLAQMQQQQQQQQQQNNNPQQQQLQQHALAGQQPQSSNHNVQADKIMGSNNVTGDGIMSNSFRANDQLCPDTCLPPRAKATFTGHCRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8Z2</accession>
    <name>A0A068U8Z2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017371001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8Z2"/>
    <dbReference type="Gramene" id="CDP04083">
        <property type="protein sequence ID" value="CDP04083"/>
        <property type="gene ID" value="GSCOC_T00017371001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8Z2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040404">
        <property type="entry name" value="Phylloplanin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34458:SF11">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34458">
        <property type="entry name" value="POLLEN OLE E 1 ALLERGEN AND EXTENSIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657433" evidence="1">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="17863" checksum="5EFF93D4DE28F455" modified="2014-10-01" version="1">MAFNGSHGIFLSLALLLTIMAATPHVGKGAISLTPAALLVNGRLYCTPTGNPSPIGNSPPLVNATVIITCPNITRVPVRTDINGFFNATLVTRPGVNLNLNLSINSIISVCQVSVQLPVRSCPVLPVRGVLRGVLTPVGLLLANALSGLTGTVGGLVNGVGGVVINVVAFAFGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9H2</accession>
    <name>A0A068U9H2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-arabinopyranose mutase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00017566001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RGP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9H2"/>
    <dbReference type="FunCoup" id="A0A068U9H2">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9H2"/>
    <dbReference type="Gramene" id="CDP04238">
        <property type="protein sequence ID" value="CDP04238"/>
        <property type="gene ID" value="GSCOC_T00017566001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9H2"/>
    <dbReference type="OMA" id="VYTKSDM"/>
    <dbReference type="OrthoDB" id="1020896at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9H2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052691">
        <property type="term" value="F:UDP-arabinopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033356">
        <property type="term" value="P:UDP-L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037595">
        <property type="entry name" value="RGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31682:SF4">
        <property type="entry name" value="UDP-ARABINOPYRANOSE MUTASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31682">
        <property type="entry name" value="UDP-ARABINOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03214">
        <property type="entry name" value="RGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP04238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39466" checksum="4833CE13816C350C" modified="2014-10-01" version="1">MAQVNIRDDEVDIVIGALHLDLTSFMEDWRAVFSRFHLIIVQDPDLKGDLKIPGGFSFDVYTKSDIESVVGSSSSSVVFSGYSCRYFGYLVSHKKYIISIDDDCIPAKDDKGELIDAVAQHITNLMTPATPFFFNTLYDPFRKGTDFVRGYPFSLRSGVQCGLSCGLWLNLADYDAPTQALKPGQRNSRFVDAVLTVPARAMLPVSGINIGFDRELVGPAMVPAFRLAKEGKFRWETVEDIWSGMCVKVICDHLGYGVKSGLPYVWRNERGNAVESLKKEWEGVKLMEEVVPFFQSMRLSQGAVTAEDCVIEMAAAVKERLEPLDPVFARASEAMVEWVKLWKVVTSRLSNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9R8</accession>
    <name>A0A068U9R8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020283001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9R8"/>
    <dbReference type="STRING" id="49390.A0A068U9R8"/>
    <dbReference type="Gramene" id="CDP05290">
        <property type="protein sequence ID" value="CDP05290"/>
        <property type="gene ID" value="GSCOC_T00020283001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9R8"/>
    <dbReference type="OMA" id="FLWEERP"/>
    <dbReference type="OrthoDB" id="1938864at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9R8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007789">
        <property type="entry name" value="DUF688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37767">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37767:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05097">
        <property type="entry name" value="DUF688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35955" checksum="9BB22C05D0279B65" modified="2014-10-01" version="1">MDMEDRRETAMEKNEASDATTRKRIKQAISVPFVWEEIPGTPKRDWKPTAPVKKPVAPPVKFIASVPFQWEEKPGKPLPCFSQQASGSPLALPLPNISSFPLSPRHFLGSENCWTGMNDQDGDQIEMLESYPASCESEADDSFCSAPSLLANRLVPTVAISNAVPVQQTSFAGLSSGQLQRPASPASETGSSTSSYETGNTNLVGASFLEWLFPLLTPQSNILEKVGSSEKEISPTQTTRQKEDIDCERNYSAALRKPHTLGELIMMSRRRSYQRKAFQMQTQNLSKDFMKKNAVGRWILGSSNFVGRFHRRWTRQLQLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAT4</accession>
    <name>A0A068UAT4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pectinesterase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00018794001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAT4"/>
    <dbReference type="FunCoup" id="A0A068UAT4">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAT4"/>
    <dbReference type="Gramene" id="CDP04723">
        <property type="protein sequence ID" value="CDP04723"/>
        <property type="gene ID" value="GSCOC_T00018794001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAT4"/>
    <dbReference type="OMA" id="YDYAYLH"/>
    <dbReference type="OrthoDB" id="773291at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAT4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14859">
        <property type="entry name" value="PMEI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357:SF8">
        <property type="entry name" value="OS01G0111000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357">
        <property type="entry name" value="OS02G0537100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657796" description="Pectinesterase inhibitor domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="5">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="179" mass="19463" checksum="7B56BE2E874EE693" modified="2014-10-01" version="1">MAYYSSFAIVLALCISFQSAIHVQGDSSLIESTCKVTNYYDLCISSLKSDLTSLNADANGLAIIMVRVAMANATATNTYLSSQVLSATNDTLMKKLIKDCAKNYSYAIEALQASLQDLDAEFYDYAYINVMAAADYPNVCHSSFRRSPGVAYPHELAAREDGLKHICEVALGIIDSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBI8</accession>
    <name>A0A068UBI8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021131001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBI8"/>
    <dbReference type="Gramene" id="CDP05836">
        <property type="protein sequence ID" value="CDP05836"/>
        <property type="gene ID" value="GSCOC_T00021131001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="153" mass="17537" checksum="1736BC22EAD05595" modified="2014-10-01" version="1">MYLYRFPTVQYDNHIPSQFVFFFLKKKILSCLECSCGQCEFSPRISIYGSSLPRSCKVTFDPKKKKTKWSASYLKGQRVGRGKESVVNEGSESAKLKLIGFSYSYVTKAIQLGNLMAIEVQLTFLEKKNKKEKVTIALNSKLSFKFNVEKKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBL3</accession>
    <name>A0A068UBL3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00020819001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBL3"/>
    <dbReference type="Gramene" id="CDP05642">
        <property type="protein sequence ID" value="CDP05642"/>
        <property type="gene ID" value="GSCOC_T00020819001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBL3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="94" mass="10119" checksum="AAB60D71ACCA3289" modified="2014-10-01" version="1">MNRKGWEILGHPLAQISSQKIYFETPLLSSSAAPSTIPPPLPPLSTATPTSALLADLLDYNSIMRPSGSVPNLEARPFSIFSIAMIFLPLVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDN3</accession>
    <name>A0A068UDN3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00023073001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDN3"/>
    <dbReference type="STRING" id="49390.A0A068UDN3"/>
    <dbReference type="Gramene" id="CDP06304">
        <property type="protein sequence ID" value="CDP06304"/>
        <property type="gene ID" value="GSCOC_T00023073001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDN3"/>
    <dbReference type="PhylomeDB" id="A0A068UDN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF51">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="174"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="10">
        <location>
            <begin position="728"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP06304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="879" mass="98548" checksum="53ADC1A068F42A64" modified="2014-10-01" version="1">MASVIPTFLPVVYDSKAEFLNFFRDTVCQADVELFKKLKMNFVVAAALLDDAVIKQTRNPSVKQWLEELRDTVYEADGLLNEINTEALRVKEENVCQSSSRNWESASDCIPSLSSKFLKKIIPQTERIAVRLEAFVKQINPLGFQAGESKRQPCQLPIPTTSLVDKTAIYGRDNDRDKIIQMLLSEDANGDRIAVIPIFGLGGIGKTTLAQLVYNDQRVKDNFSTTAWVYVSEEYDPTRITKELLRELNISFSDSRENLNSLQVKLKVGLTGKKFLLVLDDVWVSDYNQWGNLRIAFEGGLRGSRIILTTRNLYVARMMGREKSIHHMNLISEDDCWSLFVKHAFENRDGSQALEFEEIGKKIVKKCGGLPLAVKTVAGLLRSKTTSEEWEDIFMSEDWSLTSNQMIPPLSYNHLLSHPNRYQSRSTGMTQELKDVNRQLDITFWYFNNSLQQLSIAASEDDVSALYRVISNNPDLLECIDQKPFNNTPLHIAAETGRTRFALEIMSLKPSLGRVLNHDGFSPLDLALRNGHRETVRRLVRFAPELIRIQGRERITPLHYAAEVEEIDFLAEFLMKCPASIEDVTLCCETALHIAVKNGKLRAFKVLFGWLKRTNNRREILNWGDEDGNTVLHVAASTNQTEVAKLLVKYVNVNAKNHEGLTALDISNTKPPIQVNARMKKILLRAGASKASRLHQLPTLAEMLGSPEALIEKIFQFNAYLDEGLSGEMRNSMLAAAILIATSAYQSVLSPPGGVHQGDTNTSNQPAVEPGEVVMRATKFYPFLLGNSLAFGASLGIVFLLLPTTGYGVLHISLVLLMLGYIDSALTISPATPTAVCFVFAGFLLFTLIVAVRMVWKLLQRFPSASWETIGSVYFPNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDQ0</accession>
    <name>A0A068UDQ0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023111001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDQ0"/>
    <dbReference type="Gramene" id="CDP06324">
        <property type="protein sequence ID" value="CDP06324"/>
        <property type="gene ID" value="GSCOC_T00023111001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDQ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="126" mass="14411" checksum="1E2F1E1EFA635CEC" modified="2014-10-01" version="1">MTFQQLLQQTSPPTCKSLDCSDLIPQCTKKHFCLKVIILTRSQWLLVLEYSAINSVFWSLIMNVTLILNIQSRCSLHWNLLCSSFCPACHCLLDASLTSIILLLIVYHCTTFLCYNLITRPLICLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE07</accession>
    <name>A0A068UE07_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00023746001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1166"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP06780">
        <property type="protein sequence ID" value="CDP06780"/>
        <property type="gene ID" value="GSCOC_T00023746001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE07"/>
    <dbReference type="OMA" id="GWHHPIK"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE07"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47434">
        <property type="entry name" value="PROTEIN PTST HOMOLOG 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47434:SF2">
        <property type="entry name" value="PROTEIN PTST HOMOLOG 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="381"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="472" mass="53238" checksum="0ED385C6B3411CC5" modified="2014-10-01" version="1">MSALCSRFPPVFHSLTSYKLSSLPNHNYLPAYPHRNRLRTWASVSKKPRGSRRVKSNEDLYNDIREFLSAVGLPHDHVPSMKQLSEHGRQDLANIVRRRGYKFIRELLTRSAEMQINISITEEKLTGGQHIPSGGEGHHEKVKDSCEDTSLLSEANEIKEHEKSLVEDAQTNTGLDSDKDDSCSPESSIYPSMQDKVAKFIQDGELDDVEDSGFDILNERTSQDSTAIAQSPYAIESNSISVLGQQNDPVLNSADTVNGNMASSSHQVEHRVLETSSSRIDSHSSEEANIIDFKEDQEIEAQNLGNQAEINHLKFILHQKELELTQLKEEIEKEKVALSILQTKADKEIIKAQKLILEKDAELQAAEESLSELKEASSLFPVEIQYWGEGEVVEVAGSFNGWHQKIKMDSQPSSSLSDPNGSRKSRLWRSVLWLYPGVYEIKFIVDGHWTVDPQRDSVTRDTLHNNILRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEN6</accession>
    <name>A0A068UEN6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024125001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEN6"/>
    <dbReference type="FunCoup" id="A0A068UEN6">
        <property type="interactions" value="798"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEN6"/>
    <dbReference type="Gramene" id="CDP07035">
        <property type="protein sequence ID" value="CDP07035"/>
        <property type="gene ID" value="GSCOC_T00024125001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEN6"/>
    <dbReference type="OMA" id="WAYFCQG"/>
    <dbReference type="OrthoDB" id="784654at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012862">
        <property type="entry name" value="DUF1635"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431">
        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431:SF3">
        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07795">
        <property type="entry name" value="DUF1635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="279" mass="31440" checksum="383C928AB5243D26" modified="2014-10-01" version="1">MESQRGPLLNWPYLYQGKGMDELRQSLLLTTMELENTRLKAQEELKMRDDQLFQLKDLLSRTIRERDEAQEQCQRLVLDKLLLQQQQLMLQRQNQQSAPLSGISSIEDEPRRGGGVDSNNGFSSSDCEESIVSSPIIEQNPPQELTHQLQVQPQHPTTELDPTLPILTDRPLPEKGKFLQAVMKAGPLLQTLLLAGPLPQWRHPPPPLDSYQIPAPPVVVPPPPTPPTLSGHSLNQDSLLTIAAYNSNINNCGRMNRKRGYFEGSDSSTEAKYQRLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGN7</accession>
    <name>A0A068UGN7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024948001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGN7"/>
    <dbReference type="STRING" id="49390.A0A068UGN7"/>
    <dbReference type="Gramene" id="CDP07631">
        <property type="protein sequence ID" value="CDP07631"/>
        <property type="gene ID" value="GSCOC_T00024948001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGN7"/>
    <dbReference type="OMA" id="PEDECWS"/>
    <dbReference type="OrthoDB" id="2973320at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGN7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF40">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="177"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="695"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130435" checksum="BEC1B0FFB62067D2" modified="2014-10-01" version="1">MTGMEAAILSAVVSPIAKKVFELVSSLIAGKFHLHQGVEEDIRDLSSQLTAILAVLEHAEELQLDSPPIRDWLGKLKEVLFDAEDLLESFQTEALLWQRQQQARNVHPPFSASQLFMKLNVAQEIKKVLLRLEKIGREKQNFQLDAHAIDSGASSTRPSVSRNTGFIVAESDVVGRDDDKDRMINLLLSEESDRQGHVSVAPIIGMGGIGKTTLSQLVYNDDRVKSHFEFRMWVCVTDVFNYTKVLKDMIEYHTEIKYNDISSLSNVQLESRLLEFLKGKPYLLILDDVWPESFDWSDLQKLLKHGGKGSRVVVTSRSSHVANLMGTLPPHFLELLPEDQCQFLFEKIAFGPGGAKRTEETEEIGKDIVRKCKGLPLAIKVMASLLRGIDGARKWRNIQKHEIWEAEKHSDARKPQILPALSLSYNHLPAHLKRCFAYTCIYPKAYVFHKMDLIKVWKAASFILPRGQYSIEDIGEEYFDELLRRSFFQLSKVDNQETFRMHDLLHNLAESVSGPYCYQIKDNDPCNFYEKARHISLLCSAAEQPIMGIMEKSQKLRTLLSPSDHQKNFGQALDSIFQSLKYIRILDLSSSIMLELPESVGELKLLHYLDLSKTEIRRLPNSVCNLINLETLKLLSCLWLFELPKDLGKLTNLQHLELDDIFWYKLRTLPPGIGSITGLQNLHAFPVSREAGKGINELKGMLHLKGALHIKELENAANAGEANLKDKEDLVKVVFEWSNNRNGSPENAALDENIIEDLQPHPDIKEIQVIHYQGARFPAWIRDGQVKNLTSLTLNHCINCRVLSIGQLSRLQSLSLKGNLELEEWIDAPYHFLHRLKISNCPKLRDTPKIFLNLGAMKIKKCNSLKALPLIPSVMFLKLMHNLVLEDFNEHTPSFIKLLELKVIDCPKLPCLPEVFAPQKLEVSGCPLLTKLPTPEFSQRLQHLAIDACDDPTLVRAIPDTGSLYSLVISNISNLTSFPKWPHLPGLKTLYISRCNDLTSLSDETAASVPFEGMTSLELLSVRGCPNLVRFPDKELPATLKCLIISSNSGLTSLGPEEAFQNLTSLTDVNIENCPELHSLPAEGFSASLRHLLIEGCPELIKECQNVSGADCPKIQGIPDLEIEPLQVLASQNPQNPPAAWYHCLICCKGTRTIEDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGS6</accession>
    <name>A0A068UGS6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SOSEKI DIX-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024979001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms long polymer filaments with other SOKs proteins polymers (e.g. SOK1, SOK2, SOK3 and SOK4) crucial for polar localization and biological activity. Binds to ANGUSTIFOLIA (AN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SOSEKI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGS6"/>
    <dbReference type="FunCoup" id="A0A068UGS6">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGS6"/>
    <dbReference type="Gramene" id="CDP07656">
        <property type="protein sequence ID" value="CDP07656"/>
        <property type="gene ID" value="GSCOC_T00024979001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGS6"/>
    <dbReference type="OMA" id="HAEKKAW"/>
    <dbReference type="OrthoDB" id="1907705at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGS6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000067">
        <property type="term" value="P:regulation of root morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090708">
        <property type="term" value="P:specification of plant organ axis polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010369">
        <property type="entry name" value="SOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048351">
        <property type="entry name" value="SOK_DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021182">
        <property type="entry name" value="SOK_magnoliopsida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083:SF5">
        <property type="entry name" value="PROTEIN SOSEKI 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083">
        <property type="entry name" value="UPSTREAM OF FLC PROTEIN (DUF966)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06136">
        <property type="entry name" value="SOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031043">
        <property type="entry name" value="UCP031043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOSEKI DIX-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="362" mass="40653" checksum="70FBACBA02745BE5" modified="2014-10-01" version="1">MESNQVGAEVRRIHVIYFLSRKGRIEQPHLIRVHHLSRNGVHLRDVKRWLGELRGKDMPESFSWSYKRRYKSGYVWQDLLDEDLITPISDNEYVLKGSEISSTATIEEEDSDRIPSSTEENPDDDHHHHQETKMDQPTKISSPEIEEESPTFGSEQSSTLTDDSMKTKDRDQDQEKNSKKISAAPSSSASTSSTAQPSFSKSRSYSNASHLFRNLITCGAVETNDSVMLTISRRNKPPANANLSSLDKQNHLGGSQRIFGTNWNQQRQSSGRKSFDGVRASQKNNSEFNNQKTNAAHKPIYGPPCSQCGKPFKPEKLHAHMKSCKGMKAWAKYSGPAISTAAADKPAESPQENLVSGYYLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH34</accession>
    <name>A0A068UH34_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00024018001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH34"/>
    <dbReference type="FunCoup" id="A0A068UH34">
        <property type="interactions" value="2505"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UH34"/>
    <dbReference type="Gramene" id="CDP06958">
        <property type="protein sequence ID" value="CDP06958"/>
        <property type="gene ID" value="GSCOC_T00024018001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH34"/>
    <dbReference type="OMA" id="FYDFDYI"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH34"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000113">
        <property type="entry name" value="Low molecular weight protein-tyrosine-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052995">
        <property type="entry name" value="LMW-PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47439:SF1">
        <property type="entry name" value="ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47439">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="6">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="20702" checksum="B85E1C56851B51B7" modified="2014-10-01" version="1">MASTPSAAATDSSTKPFSVLFVCLGNICRSPAAEGVFRDLVKKRSLDSKFNIDSAGTINYHEGDQADPRMRAASKRRGIEITSISRPIRPSDFREFDLILAMDRENREAILSAFERWRHREPLPADAAKKVRLMCSYCKKHEEDEVPDPYYGGPQGFEKVLDLLDDACESLLESILSENTELADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJE5</accession>
    <name>A0A068UJE5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025061001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJE5"/>
    <dbReference type="FunCoup" id="A0A068UJE5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP07713">
        <property type="protein sequence ID" value="CDP07713"/>
        <property type="gene ID" value="GSCOC_T00025061001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJE5"/>
    <dbReference type="OrthoDB" id="1034349at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJE5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006462">
        <property type="entry name" value="MS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31260:SF28">
        <property type="entry name" value="CYSTATIN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31260">
        <property type="entry name" value="CYSTATIN/MONELLIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="18001" checksum="2904BAA3531CDD9D" modified="2014-10-01" version="1">MQRARRKDPYADFRQYPTNKLADLDLIHNYIRQIKESDGFDVDVYPGRCFAAVYVPRPEFKEPCQLRTDAIEMSQLALAQFNSDNRDSKGVPYEFQGIERVVSYSCNGEIFLITFQAREAETDDIKTFQAKVFDPPGLDEEEEREVMLVRLKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK78</accession>
    <name>A0A068UK78_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00027644001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK78"/>
    <dbReference type="FunCoup" id="A0A068UK78">
        <property type="interactions" value="1766"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UK78"/>
    <dbReference type="Gramene" id="CDP08624">
        <property type="protein sequence ID" value="CDP08624"/>
        <property type="gene ID" value="GSCOC_T00027644001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK78"/>
    <dbReference type="OMA" id="YPYNAGP"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UK78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000808">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein Q isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000259">
        <property type="entry name" value="RNA-binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
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            <begin position="184"/>
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        </location>
    </feature>
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        <location>
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            <end position="357"/>
        </location>
    </feature>
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            <end position="60"/>
        </location>
    </feature>
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        <location>
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            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP08624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="479" mass="52833" checksum="124CEA5E37CB6FFB" modified="2014-10-01" version="1">MAENAEIDDRVDFDDDNYIEEEDDVEEQMEDEGAGEGAEEIGEDQDEQHEDLQPGDSGKEQVFEGVRNDLGAELAENVGNPNSSNDVVENDEHAELLGLPPHGSEVFIGGLPRDVSEIDLKNLCESIGEIFEIRVMKNRDTGESKGFAFVAFKTKDVAQKAIEVLHNKEFKGRTLRCSLSETKYRLFIGNIPKVLTDNDFRKVIDDTGPGAETIELIKDPHNPNRNRGFAFVEYYNNACADYSRQKLSNTSFKLEGNTPTVTWADPKITPDHSAAAAQVKALYVKNIPENTSIEQLKELFQQHGEVTKVIMPPAKSGGKRDFGFVHYAERSSALKAIKETEKYDINGQVLEVVLAKPQSEKKFDVAHHSPSSAPLPNFIPPSGYGGFPMNPFGQVAPGYGAVAGFQQQPMIYGRGPMPAGMQMVPMVLPDGQIGYVLQQPGIQMPPVRPRRNDRGNGAGRGGTSASSDDTGRNRRYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL83</accession>
    <name>A0A068UL83_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00028587001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBM8A family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="GSCOC_T00028587001"/>
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    <dbReference type="InParanoid" id="A0A068UL83"/>
    <dbReference type="OMA" id="IYNHEEF"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL83"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000525">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP09290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="22383" checksum="A6CD39F90E45114A" modified="2014-10-01" version="1">MANPEVEAVDFEPEDDDLMDEDVDGAASPRAPIPKLKSAITGGSSSSFSAAKKTKGRGFREEATTADRNARMSAPFDSLDSEGGPGPERSIEGWIILVTGVHEELQEDELLNAFREFGEIKNLHLNLDRRTGFVKGYALIEYEDREEAEKAIHEMDGTEFYTHTIHVDWAFSKGPFKRKNMRRRSPRGHRSRSPRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULM9</accession>
    <name>A0A068ULM9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028391001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULM9"/>
    <dbReference type="FunCoup" id="A0A068ULM9">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULM9"/>
    <dbReference type="Gramene" id="CDP09172">
        <property type="protein sequence ID" value="CDP09172"/>
        <property type="gene ID" value="GSCOC_T00028391001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULM9"/>
    <dbReference type="OMA" id="TCYPLDS"/>
    <dbReference type="OrthoDB" id="1924189at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULM9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312:SF132">
        <property type="entry name" value="OS01G0855200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="560" mass="63042" checksum="5C7CB4C9EAE1A53A" modified="2014-10-01" version="1">MGVKVAPTCFHWSQPSFPHSPSSSQTLASAISSPSSKRRSFSMCRYVGRSNFLGNSCSNLYRTGSWEQEQKSKPRFIRRVCSATLDSFSDEEFSKRIQELALRFQLSDDDDDEQAEEAENRPESRTRESYDSRNGDAVLLEDQSFHPLEPPYWPEREEIIPASIERKANSVELPLSLRIIKRKKQWEEGFREVGESAYCSVKKAFSSMVFIIRELQSYTLQMRELLFYEDLQGILVRVQKEMHASFVWLFQQVFSHTPTLMVYVMILLANYSVHSMANNTALAATPHPQVCAASAESVSEVGDQSHGKSKFDSSFIKSFSVSSSSGKTTSIGGSNGGGGKHRPAASGTDGDGRFDRMSSDYHRTIVPDGVSSVGNPSRTSEEVSVSGQVTGEEEMRLWNSMVEEASKMQSASRDEALDHETMQRFVSPVNAKIESDDYADYFRTELLYQTGLAQEPNNSLLLANYAQFLYLVIRDYDRAEEFFKRAAKVEPKDAEALNKYASFLWQVRKDLWAAEETYLEAISADPSNSYYAANYAHFLWSTGGEDTCFPLSSPDTENDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM87</accession>
    <name>A0A068UM87_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030045001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM87"/>
    <dbReference type="FunCoup" id="A0A068UM87">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UM87"/>
    <dbReference type="Gramene" id="CDP09645">
        <property type="protein sequence ID" value="CDP09645"/>
        <property type="gene ID" value="GSCOC_T00030045001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM87"/>
    <dbReference type="OMA" id="YHERRHI"/>
    <dbReference type="OrthoDB" id="1703243at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF2">
        <property type="entry name" value="OS09G0309100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="728" mass="84053" checksum="7F1E6B22646541D9" modified="2014-10-01" version="1">MEIVESIFDIPVQSPPAEEFSAADLDWTKFGTIERHDDVALIPYARVDAFIIGECLNAECPTRFHIERGRKRARGSLQEYKDDEYLEYRLYWCSFGPENYGEGGGILPSRRYRLNTRNRAARPQSMRGCTCHFVVKRLYARPSLALLIYNNRRHVNKSGSICHGPLDRDAIGPGAKKIPYICNEIQQQTMSMIYLGIPEENVLEKHIEGIQRYCGSNAKVNSLASQYVHKLGLIIKRSTHELDLDDQASVKLWVERNKKSVFFYQDTSETDPFILGIQTEWQLQQMIRFGHRSIVAADSTFGIKKLKYPLCTLLVFDSRQHALPVAWVITRSVVKSDVAKWMKALVDRVHTVDLGWKVNAFLVDDAAAEIDPIRQNSLLCLPFCFSIFSCPVLFSLWRIRRSWLRNILKKCNNIEVQREIFKRLGEIVYSIWGEVDYMVPLEKFTQDFVDQTAFLNYFRATWLPKMEMWLTGMRTLPLASQESSGAIEAYHVKLKVKLYDDSHLGAFQRVDWLVHKLTTELHSSYWLDRFADESDSFQNVKEEYLASTSWHRALQIPDTAVTLDDKDHPFAKVLSQRESTRTRIVWNPGSEFSLCDCEWSMQGNLCKHVIKVNMICENLRSYQPTLSFQSFQDILMSLQEKPLDDSIALDLSTAWAHQMLDQIQKLVELNSSDDISTVVNNMPLRWTTKKGRTSCGKPLTTLALPSCSKNDAAARKRNRKRKRLSRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMR9</accession>
    <name>A0A068UMR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028052001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMR9"/>
    <dbReference type="FunCoup" id="A0A068UMR9">
        <property type="interactions" value="1336"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMR9"/>
    <dbReference type="Gramene" id="CDP08918">
        <property type="protein sequence ID" value="CDP08918"/>
        <property type="gene ID" value="GSCOC_T00028052001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMR9"/>
    <dbReference type="OMA" id="YVSIAKM"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMR9"/>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045489">
        <property type="term" value="P:pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF4">
        <property type="entry name" value="POLYGALACTURONATE 4-ALPHA-GALACTURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25557">
        <property type="entry name" value="GAUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="683" mass="77708" checksum="C7CF12FEF1034538" modified="2014-10-01" version="1">MGTNKRGITVAGKSSKGGGYGSRLPGAAVLIFCLVVSPSFLFLVGRGIFYTSSTDQDKISTSSSLQDLDWRERLALQHVMDVIKANTNDLGPLSLDSFRKTNLSASWKFVGQETPAENSALSFESNQRGAAIKHDISRNKVDASLEEDRSQVIDAPAKVARRQLRQKRREKRAADLVKQDEEVTVKLENAAIERSKSVDSAVLGKYSIWRKENENENADSTVRLMRDQMIMARVYISLAMMKDKPDLGRELQNRLKESQRALGEATTDSDLHHSAAEKIKAMGQVLSKAREQLYDCKLVTGKLRAMLQSADEQVRSLKKQSTFLSQLAAKTIPNGIHCLSLRLTIDYYMLSPEKRIFPRSENLENPNLYHYALFSDNVLAASVVVNSTIMNAKEPEKHVFHLVTDKLNFGAMNMWFLLNPPGKATIHVENVDEFKWLNSSYCPVLRQLESAAMKEYYFKAAHPTTLSAGSSNLKYRNPKYLSMLNHLRFYLPEVYPKLDKILFLDDDIVVQKDLTGLWSVNLRGKVNGAVETCGESFHRFDKYLNFSNPHIARNFDPNACGWAYGMNIFDLKEWKKKDITGIYHKWQNMNEDRVLWKLGTLPPGLITFYGLTHPLEKSWHVLGLGYNPSVDRSEIDGAAVIHYNGNMKPWLELAMTKYRSYWTKYIMFDHPYLRNCKLTKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMU7</accession>
    <name>A0A068UMU7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00028091001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMU7"/>
    <dbReference type="FunCoup" id="A0A068UMU7">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMU7"/>
    <dbReference type="Gramene" id="CDP08948">
        <property type="protein sequence ID" value="CDP08948"/>
        <property type="gene ID" value="GSCOC_T00028091001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMU7"/>
    <dbReference type="OMA" id="CTHVRNE"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000003">
        <property type="entry name" value="Cytosolic ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000003">
        <property type="entry name" value="L-ascorbate peroxidase, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF59">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 1, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="74"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="250" mass="27307" checksum="D3A9EFD7DE5CE52E" modified="2014-10-01" version="1">MGKSYPTVSAEYLKALDKAKRKLRGLIAEKNCAPLMLRLAWHSAGTFDQGSKTGGPFGTMRLKAEQGHEANNGIDIAIRLLEPIKEQFPTLSYADFYQLAGVVAVEVTGGPDIPFHPGRQDKTEPPVEGRLPDATKGCDHLRDVFVKQMGLSDQDIVALSGGHTLGRCHKERSGFEGPWTANPLIFDNSYFTELLSGDKEGLLQLPSDKALLSDPAFRPLVEKYAADEDAFFADYAVAHQKLSELGFAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP81</accession>
    <name>A0A068UP81_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030856001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP81"/>
    <dbReference type="FunCoup" id="A0A068UP81">
        <property type="interactions" value="1444"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UP81"/>
    <dbReference type="Gramene" id="CDP10206">
        <property type="protein sequence ID" value="CDP10206"/>
        <property type="gene ID" value="GSCOC_T00030856001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP81"/>
    <dbReference type="OMA" id="MYFQALN"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UP81"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="281" mass="31765" checksum="C11C1C049305991E" modified="2014-10-01" version="1">MKEHSWLCTFITQISLCFCVYLAFNMGDRTESSSRPVETYFMSVAGGFRPENEQTLLLKLMEKVAKVYKVQFVVSISELGENDPLGLNATWYFQSLKLPWYTTKSFKGQRPGSYLKHTKVQYGKTLDIVIVNTELFQGPSAGAIEHQLLWLMKTLEESTSDWRIVVGFHPLLACNGSTEAKDNPLCLHEMFLNHRVDAYLSGHACTEHVHKQSAKQPGNADQPGKGPCLTPIRRIFDQNKEKVNGLLLHRVSSLELVTYSINLEGDVAHKIELQQSGREAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPM0</accession>
    <name>A0A068UPM0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="6">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00030887001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPM0"/>
    <dbReference type="FunCoup" id="A0A068UPM0">
        <property type="interactions" value="2084"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPM0"/>
    <dbReference type="Gramene" id="CDP10227">
        <property type="protein sequence ID" value="CDP10227"/>
        <property type="gene ID" value="GSCOC_T00030887001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPM0"/>
    <dbReference type="OMA" id="TIMINIQ"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPM0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000012">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0385">Hypusine</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="17216" checksum="5955F46E86B9402A" modified="2014-10-01" version="1">MSDDEHHFESKADAGASKTFPQQAGTIRKNGYIVIKARPCKVVEVSTSKTGKHGHAKCHFVGIDIFSGKKLEDIVPSSHNCDVPHVNRSDYQLIDISEDGFVSLLTESGGTKDDLRLPTDDTLLAQIKGGFEEGKDLVVSVMSAMGEEQICAVKDIGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQQ5</accession>
    <name>A0A068UQQ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031817001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein functions as a defense against chitin containing fungal pathogens.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="HG739132">
        <property type="protein sequence ID" value="CDP10880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQQ5"/>
    <dbReference type="Gramene" id="CDP10880">
        <property type="protein sequence ID" value="CDP10880"/>
        <property type="gene ID" value="GSCOC_T00031817001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQQ5"/>
    <dbReference type="OMA" id="RAGIKNC"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQQ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000015">
        <property type="entry name" value="Acidic endochitinase SE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF21">
        <property type="entry name" value="ACIDIC ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="263" mass="28850" checksum="BFE9C10A174319A0" modified="2014-10-01" version="1">MEATNSTTGRMLDEYFRQTECGIIAVYWGQNAREGTLSDTCSSGLYKIVNIAFLPTFGNGRTPKLNLAGHCDPSSGGCKKLSDSIRQCQRRGIKVMLSIGGHIGSYSLSSANDARQVADYLWNNFLGGKSKSRPLGDAVLDGIDFDIEHDQGQSYYATLARALSDYSKKGKKVYLTAAPQCPFPDRNLNTALSTGLFDYVWIQFYNNPSSSTAAARNGYVPPQVLKSKVLPLVKRSSKYGGIMLYDRYYDKQSGYSSAVKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URJ0</accession>
    <name>A0A068URJ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031898001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URJ0"/>
    <dbReference type="Gramene" id="CDP10932">
        <property type="protein sequence ID" value="CDP10932"/>
        <property type="gene ID" value="GSCOC_T00031898001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URJ0"/>
    <dbReference type="OMA" id="RRPINDP"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URJ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000005">
        <property type="entry name" value="Germin-like protein subfamily 1 member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019610795" description="Germin-like protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="12">
        <location>
            <begin position="66"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="224" mass="23823" checksum="4B3FAC23984158A0" modified="2014-10-01" version="1">MAAAGFIVTLAICLALSSSFSHAFDDNPLQDFCVAVSDTSAAVFVNGKICKNPKQVTSDDFLGTGFNIPVDTNNSLGSGFKLVDVNVIPGLNTLGLSLLRVDFAPGGVIPPHTHPRATEAVVVIEGTIYIGFVTSNPADNTKNRLYAKILKPGDIFVLPIGLVHFLRNVGKTKAMGIVAFNSQNPGTITIANAVFGTEPLISPEVLTKSFQLDKKVIEYLQSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URM2</accession>
    <name>A0A068URM2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030896001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URM2"/>
    <dbReference type="STRING" id="49390.A0A068URM2"/>
    <dbReference type="Gramene" id="CDP10233">
        <property type="protein sequence ID" value="CDP10233"/>
        <property type="gene ID" value="GSCOC_T00030896001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URM2"/>
    <dbReference type="OMA" id="GWHIQII"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URM2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="113" mass="12133" checksum="31F690B738C2D651" modified="2014-10-01" version="1">MIDLNPSVNSATRDASRAMDVDVVVSKPFAVVDEITEGSPAAEDGVQLGDQLVKFGCVEFGENLLQRLAAEAQTNQGRAIPVVVLRQGARVSLAVTPRPWQGRGLLGWHIQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URT2</accession>
    <name>A0A068URT2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00033189001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URT2"/>
    <dbReference type="Gramene" id="CDP11136">
        <property type="protein sequence ID" value="CDP11136"/>
        <property type="gene ID" value="GSCOC_T00033189001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URT2"/>
    <dbReference type="OMA" id="ENPMCSS"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URT2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="329" mass="37686" checksum="E006A021214E6906" modified="2014-10-01" version="1">MLNMTSKSFESNCFQDFLESLPKEIFWESFDIYQWKGFWFHPSILQSTIALSTKFVPRDDDIILASSLKVGTTWLKALCLSINNGADQENEDILTKGSPHLFVPTIESMVFVPNSDSVLSGMASPRLLHTHLPYSLLPDSIKNSGCKIVYLTRNPKDTFISFWHYFNSTKVDTCGTERPLVIGIKQQISLEKAFESFCNGTYLYGPIFDHALEYHKESSKMPQKILFMKYEELKKDPKGQLKKLASFLGKPFTEEEKVDKILWRCSLERLKNLEVNKNGVNPWNWLANSSYFRLGVTGDSKNYLTAEMEERLDQIARTKLEASGLDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USB9</accession>
    <name>A0A068USB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00033250001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USB9"/>
    <dbReference type="FunCoup" id="A0A068USB9">
        <property type="interactions" value="1982"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USB9"/>
    <dbReference type="Gramene" id="CDP11172">
        <property type="protein sequence ID" value="CDP11172"/>
        <property type="gene ID" value="GSCOC_T00033250001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USB9"/>
    <dbReference type="OMA" id="WICVEEV"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901652">
        <property type="term" value="P:response to peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF8">
        <property type="entry name" value="RNA RECOGNITION MOTIF (RRM)-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="363"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="902" mass="98927" checksum="286A92FD9FBEF93D" modified="2014-10-01" version="1">MADRNSSTNGNPNVAAAAAAGAAATGAVAKTIWMKQAEEAKLKSEAEKTAAAKAAFEATFKNSSNNTAAAAGSEDDDDDEDEEERERRRLALKPIGPVDPGKCTAAGAGIAGGTACVGSTFVVVTKDADGRKLPHGGAQVKVRVSPGVGVGGTEQEGIVKDMGDGTYTVTYVVPKRGNYMVNVECNGKAIMGSPFPVFFSSGPTTGGLLGVAPSSTYPNMVNQTMPNMPNYSGSVSGAFPGLLGMIPGIVQGASGGVVLPGIGASLGEVCREYLNGRCAKTDCKFSHPPHNLLMTALAATTSMGTVSQVPMAPSAAAMAAAQAIVAAQALQAHAAQAAQAQAQSAKDSSGSADKEGKNDTLKRTVQVSNLSPLLTVDQLKQLFGLYGTVVECNVTDSKYFAYIEYSKPEEATAALGLNNMDVAGRPLNVEMAKSLPPKSAILGSSSLPLMMQQAVAMQQMQFQQALLMQQTLTQQQAANRAASMKTATELAAARAAEISKSLNPNGIVAEDKEADRKSRSPSTTRARSRSKSRSPVSYRLRRKSRSITPPRRYSRGYRSRSPVRSRHYSSYEHERRSYRDSRDDSGRSRRRDSGKSHDRHSPVSRRRRSRSGSPRTRRSYRDDSDSPKRHRDSPSHRRRKSSCANSRSPDHHRGSKSSPRNDESRAKHRKQSRSRSAEVNHNSGDRMDESREEKSKHKERRRSRSSSTGGKTREEKSKHKERRRSRSLSTEDKIRKRSRLSPRVSGETKSKHKRRSRSRSPEKRHHVGSKVDKNSEEKSKHHERRRSRSRSTEGKRHKSCGMSPRRTDERKTKHRKRSRSRSTEHKYHSSDNGLQESKHENVKHLKERPTESDDSSMEPGPKDLNDSENDDGHMEINKRDERDYERTEATVTELKPYQRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTZ7</accession>
    <name>A0A068UTZ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DEAD-box ATP-dependent RNA helicase 41</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00033127001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX59 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTZ7"/>
    <dbReference type="FunCoup" id="A0A068UTZ7">
        <property type="interactions" value="1558"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTZ7"/>
    <dbReference type="Gramene" id="CDP11098">
        <property type="protein sequence ID" value="CDP11098"/>
        <property type="gene ID" value="GSCOC_T00033127001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTZ7"/>
    <dbReference type="OMA" id="DESFCIR"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23022">
        <property type="entry name" value="zf-HIT_DDX59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.220:FF:000002">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="162"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="349"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP11098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="519" mass="56995" checksum="D53F71897C2D62B6" modified="2014-10-01" version="1">MENRESANCSEPSASAAGNDVKQRCWDQREALPGEPRCVICGRYGEYICDETNDDICSVECKRILLDRIAKSQPPVPCPSPVKLPATDECYYVREGNDKSEAGSLSSDQVELLRRKLEISIRGDLVPAPILSFPSCNLPEKLLQNLEVAGFEMPTPVQMQAIPSALIGQNLLVSAETGSGKSGSFLVPIVSYCAKFNADKPHGERKPLAMVLTPTRELCIQVEEQAKLFGKGLPFKTALVVGGDAMAGQLYRIQQGISLIVGTPGRLIDLLAKHDIELDSVSILVVDEVDSMLERGFHEQVMQIFRALSQPQVLMYSATIPKDVQKMANSMVKDLTIIAVGKPNKPTGAVKQVVIWVDSKQKKQKLFDILTSKQHFKPPVVVFVSSRIGADLLSEAIGITTGIKAVSIHGEKSMKERREILKSFLVGEVLVIVATGVLGRGIDLLHVKQVIVFDMPNSIKEYVHQIGRASRLGEEGSAMVFVNEENKNLFRDLVQILKSSGAADCWFLLFLLKGRRSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UU30</accession>
    <name>A0A068UU30_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034203001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UU30"/>
    <dbReference type="Gramene" id="CDP11729">
        <property type="protein sequence ID" value="CDP11729"/>
        <property type="gene ID" value="GSCOC_T00034203001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UU30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="65" mass="7608" checksum="47E560ADD933137E" modified="2014-10-01" version="1">MKENNFETYGCFTSYSDIDNIRRDMNYLTSHARHMIDIGSLSVRLVPVVLMLVLIAIRWNPLHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUD5</accession>
    <name>A0A068UUD5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00035148001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUD5"/>
    <dbReference type="FunCoup" id="A0A068UUD5">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUD5"/>
    <dbReference type="Gramene" id="CDP11874">
        <property type="protein sequence ID" value="CDP11874"/>
        <property type="gene ID" value="GSCOC_T00035148001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUD5"/>
    <dbReference type="OMA" id="NCSCNAC"/>
    <dbReference type="OrthoDB" id="643280at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000005">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000227">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000250">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974">
        <property type="entry name" value="OS07G0415500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47974:SF19">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655215" description="Receptor-like serine/threonine-protein kinase" evidence="17">
        <location>
            <begin position="29"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="19">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="20">
        <location>
            <begin position="355"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="507"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="838" mass="93259" checksum="01710B5FB9C98233" modified="2014-10-01" version="1">MKTKKSISPPMLLLLFLYLSLKPHLSIGADTISANQTLSGDETLVSKDGNFELGFFEPGNSSNLYIGIWYKKVSVQTVVWVANREIPVKDKYSSELTIQDGNLVLLNESKMPVWFTNVTSASSRSSPVIAVLLDNGNFILTQGSSSSSLNLSDPSSIPSLWESFDNPTDTWLPGGKLSYNKITRKLQILTSWKNSEDPAPGLFSLELDRSNNQYLIKWNRSQEYWTSGPWNGNIFSLVPEMRLNYIYNFTYINNTNETYFTYSLYNPSIISRFIMDVSGQIKQLSWLDNTKEWNMFWAQPRQQCEVYAYCGAFGACNENSLPFCNCLDGFKPKSEEDWDLKDYSGGCERKMELQCPSNSSGKVKKDKFWEYPQMQLPKNPVSVTVDSAGECESTCLNNCSCSAYYFDSNGSCSNWNGGILGLEQLSANDGSGRTINVRLAASEFSSGKNTTGIVIGAVVGSVVLVLVLLCLVLFVIWRRRSKMVGSGKAVEGSLLAFSYRDLQNATKNFSEKLGGGGFGSVFKGTLPDSTVVAVKKLESIGQGEKQFRTEVSTIGTIQHVNLARLRGFCSEGDKRLLVYEYLENRSLDSHLFRDNESMVLDFKTRYQIALGTARGLAYLHEKCREVIIHCDIKPGNILLDAEFCPKVADFGLAKLMGRDFSRVLTTMRGTRGYLAPEWISGVAITAKADVYSYGMMLFEFISGTRNSENSLDGVVKFFPTWAARVIIEEGDILSLLDPKLDRVADAEEVSRLCKVACWCVQDEENHRPSMGQVVQILEGLLEVNLPPIPRSLQVFVDSQEHIVFFTESSSNQSSETQSKTSSTSANSKSTISSKDSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUF3</accession>
    <name>A0A068UUF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">plastoquinol--plastocyanin reductase</fullName>
            <ecNumber evidence="3">7.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00035179001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 oxidized [plastocyanin] + a plastoquinol + 2 H(+)(in) = 2 reduced [plastocyanin] + a plastoquinone + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:22148"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="7.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUF3"/>
    <dbReference type="FunCoup" id="A0A068UUF3">
        <property type="interactions" value="1179"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUF3"/>
    <dbReference type="Gramene" id="CDP11894">
        <property type="protein sequence ID" value="CDP11894"/>
        <property type="gene ID" value="GSCOC_T00035179001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUF3"/>
    <dbReference type="OMA" id="FTPWTET"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009496">
        <property type="term" value="F:plastoquinol--plastocyanin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03471">
        <property type="entry name" value="Rieske_cytochrome_b6f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.700:FF:000002">
        <property type="entry name" value="Cytochrome b6-f complex iron-sulfur subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000007">
        <property type="entry name" value="Cytochrome b6-f complex iron-sulfur subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.700">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01335">
        <property type="entry name" value="Cytb6_f_Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023960">
        <property type="entry name" value="Cyt_b6_f_Rieske"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057415">
        <property type="entry name" value="TM_PetC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045928">
        <property type="entry name" value="Cytb6fFeSPetC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010001">
        <property type="entry name" value="PRK13474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25471">
        <property type="entry name" value="TM_PetC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="232" mass="24909" checksum="E4A3BFA01FBA080C" modified="2014-10-01" version="1">MASSTLSPVPPSQLCSSKSSMYCPSQSLFLKPMMMRSGKLGWGKDKRMKVSCMATSVPADDRVPDMGKRELMNLLLLGAVSLPTAIMVVPYAAFFVPPGLGGASGGTVAKDALGNDVLVDVWLKNHGPGDRTLTQGLKGDPTYLVVEKDRTLATYGINAVCTHLGCVVPWNPAENKFICPCHGSQYNNQGMVVRGPAPLSLALAHADIDEGKVVFVPWVETDFRTGEDPWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUY1</accession>
    <name>A0A068UUY1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035581001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUY1"/>
    <dbReference type="FunCoup" id="A0A068UUY1">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUY1"/>
    <dbReference type="Gramene" id="CDP12176">
        <property type="protein sequence ID" value="CDP12176"/>
        <property type="gene ID" value="GSCOC_T00035581001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUY1"/>
    <dbReference type="OMA" id="MQSWQLA"/>
    <dbReference type="OrthoDB" id="1901658at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044260">
        <property type="entry name" value="SKIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47124">
        <property type="entry name" value="F-BOX PROTEIN SKIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47124:SF1">
        <property type="entry name" value="F-BOX PROTEIN SKIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="217" mass="24903" checksum="921AD6CDBBA05CB5" modified="2014-10-01" version="1">MVENVAAVVPPEKQSGASMMEQLVPEITTHALSYLDYPSLCRLSMTNSQMRKAANDDNAWKALYHKDFTLEQDSVIPVNGWKAYYAATRAIVNINNEFFRIIKERSLAEMGHFWLNADYVKCFHASGESFTGYSAVMQSWQLAFNWEQGFNFQVQDVRARVLTDMAWVAMKAYVDMETGPFNVTNIFEFHNGRWYMVHHHTSVMMVNGGAEQQMMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUZ1</accession>
    <name>A0A068UUZ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00035602001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUZ1"/>
    <dbReference type="FunCoup" id="A0A068UUZ1">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUZ1"/>
    <dbReference type="Gramene" id="CDP12191">
        <property type="protein sequence ID" value="CDP12191"/>
        <property type="gene ID" value="GSCOC_T00035602001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUZ1"/>
    <dbReference type="OMA" id="AHTHERS"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUZ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000002">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF130">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38114" checksum="B49AA8EA11537282" modified="2014-10-01" version="1">MVSGDIARTVVGIIGNVIALVLFLSPVPTFVRICKKKSVEQYSAVPYLATFINCALWVLYGLPMVHPNSTLVVTINGTGFVIEVVFLLLFIAYSDPKKRLKVVVIVVVESLSVAVLALLVLTLAHTTKLRSAVVGSICMAANIMMYASPLAVMKLVITTKSVEFMPFFLSLASFANGISWTAYALIRFDPFIAAPNGMGSLLGLAQLMLYATFYKSTKRQLAERKARGEVGLTEKAGNGHTKSTTIVAIDGSRGESPEWHESTQTDALGGRPFPCPALAQLADFHRLFLRRFNVCSQFLSPHFFLILIRAAIHIWSCITSKTCSQSLFACFLFLIFFSFSSLEEAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV56</accession>
    <name>A0A068UV56_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035719001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV56"/>
    <dbReference type="FunCoup" id="A0A068UV56">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UV56"/>
    <dbReference type="Gramene" id="CDP12276">
        <property type="protein sequence ID" value="CDP12276"/>
        <property type="gene ID" value="GSCOC_T00035719001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV56"/>
    <dbReference type="OMA" id="ICVSRAM"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV56"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000199">
        <property type="entry name" value="Thioredoxin-like 1-2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF17">
        <property type="entry name" value="THIOREDOXIN-LIKE 1-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="105"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="275" mass="29931" checksum="E8C2FBA8D4F6946E" modified="2014-10-01" version="1">MACCLKTGFYVSGSSDTLLGCRAKGSLGVSPSVEALQLSNSRSKDFMGKQLDYSVQNSTYWDVKAPTTFSVKARASISVSRALRWWEKTLKPNMIEIHSAQELVDSLLNAGDRLVIVDFYSPGCGGCKALHPKICQLAESNPNAIFLKVNYEELKPMCYSLHIHVLPFFRFYRGAEGRLCSFSCTNATIKKFKDALAKYGTEGCSLGPARGLEESELLALASSGQISRNVPLGYATEKKDKQVQDVVLNGFDLSSSVVKDENKRGVNGGSAVVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UW72</accession>
    <name>A0A068UW72_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00036134001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739151">
        <property type="protein sequence ID" value="CDP12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UW72"/>
    <dbReference type="FunCoup" id="A0A068UW72">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UW72"/>
    <dbReference type="Gramene" id="CDP12524">
        <property type="protein sequence ID" value="CDP12524"/>
        <property type="gene ID" value="GSCOC_T00036134001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UW72"/>
    <dbReference type="OMA" id="PEERSAC"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UW72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="79" mass="8413" checksum="6CE1D047CC731C2D" modified="2014-10-01" version="1">MSTRVALKAKGGKSNRNKASAAAAGEEDGPSTVKIVTDWTNWGLHKAKVVAHYGFIPLIIVIGMNSEPKPSWAQLLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWC1</accession>
    <name>A0A068UWC1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00036269001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWC1"/>
    <dbReference type="FunCoup" id="A0A068UWC1">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWC1"/>
    <dbReference type="Gramene" id="CDP12597">
        <property type="protein sequence ID" value="CDP12597"/>
        <property type="gene ID" value="GSCOC_T00036269001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWC1"/>
    <dbReference type="OMA" id="MIHYIAG"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWC1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Berberine/berberine-like" evidence="3">
        <location>
            <begin position="256"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="317" mass="35925" checksum="486ACD0AEF7B9FD6" modified="2014-10-01" version="1">MGEDLFWAIRGGGGASFGIIIAWKVSLVSVPQKVTVFNLTKTSDQNATQLVHQWQHIADKIDENLLIRLFITSSTSPQTGKKSIVVSFTSLFVGGIDQLLSLMQKSFPELGLAKEDCIEMSWVESTVYFANIPGAASGEVLLDRNSSKSYFKGKSDYVKKPISVKGLEGLWKRLFAEEEEDMEAYFQLQFSPYGGMMSEISESATPFPHRRGNIFMIHYIAGWDEKGNAESKRHVNWTRRIYSYMAAYVSKFPRAAYLNYRDLDLGVNKIKGNTSYKQASIWGTKYFNQNFDRLVHVKTKVDPSNFFRNEQSIPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX43</accession>
    <name>A0A068UX43_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00035578001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UX43"/>
    <dbReference type="Gramene" id="CDP12173">
        <property type="protein sequence ID" value="CDP12173"/>
        <property type="gene ID" value="GSCOC_T00035578001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX43"/>
    <dbReference type="OMA" id="SAWHRDW"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UX43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15315:SF26">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15315">
        <property type="entry name" value="RING FINGER PROTEIN 41, 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="750"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="931"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1166"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1186"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1298" mass="142507" checksum="61986D73BD62015C" modified="2014-10-01" version="1">MDVELVTEGTSDDEGYRIDENNEEYMNFDGERCGICMDIVIDRGVLDCCQHWFCFTCIDNWATITNLCPLCQNEFQLITCVPVYDTIGSNKTDEDSYSRDDDWCIEGKNNTLSFPSYYIDENAVVCLDGDGCKIRSRSAAMEADSNLDTSIACDSCDIWYHAFCVGFDPEGACENSWLCPRCLVDQLPKKLDGVLVPRLGNQHEPENARSGGSGEAAFSGKVSVSVADAGETAVVVSVVEGSRRAEEPGGEHSTLDFTTDTKADTSLSSNVAFAPQCGDLSSERLGFVPKSESEELKLSLSGNICFSSQFPSIDLTVKADKEETGEQKLVNELGMSSTKCSSILLEDKMAKSGLDLHLGLSVNSSSTVDMINNTSMDDHELGLVYQKSSSGHLLSADGMVPHEEVILTVGRMMPDKNDDTTLVSGEKRKHKDTGSLDDGECKAEIDANAPLKKVKVEAIEGTKLTPLKDPVPYDSRQFSSTTNIENSEPTCASEKKNVSDVIMDIVQETGRRRPKPLAHANSSNISSRKREKSENAAGLRVKKIMRRTDEDADSSVLVQKLRKEIREAVRNKSSKEIGESLFDPKLLAAFRAAVSGSVTETKKPPLDLKAKKALLQKGKVRENLTKKIYGMGGRRRRAWTRDCEVEFWKHRCSNISRPEKIQTLKSVLDVLRNDTVNKEIKHHKEGEASSILSRLYLADTSIFPRKHNIRPVSASKGDAVEKNQEQNTPEKLEVNPMKHEVSKKPVVSVISDSNGTKKGASGVKAEAASTKSCPNNRTERPSTSKLGGSKVASEQEITSATGSMKTDKRKWALEVLARKTAVTPTTGVQEKEEDSVMLKGNFPLLAQLPKDMRPSLAPIRHNKIPIAVRQAQLYRLLEHFLRKANLSIIRRTAETELAVADAINIEKEVADKSNSKLVYINLCSQELSRRSDNMNLSRDAETSPPTSGVSSDGEKVTNDSNLEVNEALKTAGLLSDTPPNSPSKPVEEIKEDAGFLNKSESDGPDNVFEMDSQPELDIYGDFDYDLEDDYFVGASALKISKLQQEVSKMKVLFSTLNPDASNGSQDICDHEGSAGVGPTMASSGHEFLTDAGNSTVDGRANDNQPQNTRVDEVYGELSLAECEELYGPDKEPLIEKYPETALVKPCELVAGKEIVMENGCHGSSEMAKTSESKSGNLAVSEAHQGSVGSVNSPSHSQNTEKVQRKEKMSTVDSNKLSDSRNFVSKKVEAYIKEHIRPLCKSGVITVEQYRWAVGKTTEKVMKYHSKEQNANFLIKEGEKVKKLAEQYVEAAQQTAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXB1</accession>
    <name>A0A068UXB1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00037648001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068UXB1"/>
    <dbReference type="FunCoup" id="A0A068UXB1">
        <property type="interactions" value="442"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP12942">
        <property type="protein sequence ID" value="CDP12942"/>
        <property type="gene ID" value="GSCOC_T00037648001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXB1"/>
    <dbReference type="OMA" id="SSNCPYQ"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXB1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000012">
        <property type="entry name" value="Aspartyl protease family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000014">
        <property type="entry name" value="Aspartyl protease family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF826">
        <property type="entry name" value="ASPARTYL PROTEASE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658329" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="104"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="464" mass="50695" checksum="4CB7A05DE0CF594E" modified="2014-10-01" version="1">MVFVDGKVLVFMGFIMLISGIHSSEASGSASGTFGFDIHHRYSNPVRSIFDFDGLPEKHSFDYYAAMAHRDRYNRGRYLAGTTTPVTFVAGNDTHRLNSLGFLYYANVSVGTPELWFLVALDTGSDLFWLPCDCTTSCVRGLVTRSGKRIDFNMYSPDTSSTGMTVPCNSTMCDARRRACSASRNACAYEVSYLSSNTSSTGLLVEDVLHLATDDSQQKVVDAPITLGCGIVQTGGFLDGAAPNGLFGLGMDTISVPSTLASKGLAANSFSMCFGNDGIGRIVFGDKGSTDQGETPFNLHQLHPAYNISITQIAVGENITDVDFTAIFDSGTSFTYVNDPAYSIITENFNSRVQQPRYPSDSQIPFEFCYNLSPNETRSDIPPLNLTMKGGDPFSITDPLELFSLSNNRYIYCLAVIKSGDVNIIGENFMTGYRVVFNRENMTLGWKPSNCECSLFLLPHATTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY11</accession>
    <name>A0A068UY11_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vinorine synthase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00038181001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY11"/>
    <dbReference type="STRING" id="49390.A0A068UY11"/>
    <dbReference type="Gramene" id="CDP13291">
        <property type="protein sequence ID" value="CDP13291"/>
        <property type="gene ID" value="GSCOC_T00038181001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY11"/>
    <dbReference type="OMA" id="FCATKVE"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY11"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF17">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49674" checksum="0DF370AB24166C65" modified="2014-10-01" version="1">MKVDVQVISRYTIKPSSPTPDHLQHYPLSFLDQINPPVFMPLVLFYPSEQNHLITSTPGPDKLNQLKKSLSEALTRFYPLAGRLIGNTYVDCNDEGIPYVEARASCGLSDFLDNPIPGELNKFLPCDLDDVKDIGMVIQVTLFECGGVAVGVAISHKIADATSLFLFVTSWATISRRDSHDTRSPIYESAAIFPPRDVAGYNHALGMVKKDEIVTKRLVFTATKIASLREKYTTNSNTATGDEYHQIRPTRIEALSAFIWTRFLTATTGHKVNRDKMYMLNHAVNLRPRMHPPLSECYFGNLSRPAITIPSFDNDEQGYGIVNQVRDAIRNVGGDQYVTKLREGDKHLNFIRERAKLVNKGEVVSFSFTSLCRFPSYEADFGWGKPVWIGSASLTFKNLVVFLDTRSGDGIEAWINMKLEDMAKLEADKELLKYVSTSTDAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZW9</accession>
    <name>A0A068UZW9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00039125001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZW9"/>
    <dbReference type="FunCoup" id="A0A068UZW9">
        <property type="interactions" value="3190"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZW9"/>
    <dbReference type="Gramene" id="CDP13971">
        <property type="protein sequence ID" value="CDP13971"/>
        <property type="gene ID" value="GSCOC_T00039125001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZW9"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZW9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="49"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="268"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP13971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="591" mass="66071" checksum="EEB8C7A500E532E8" modified="2014-10-01" version="1">MASAQGSNRNRALTDTRFSDLKPPLSQPVLDALTNSGFDFCTPVQAATIPLLCSYKDVAVDAATGSGKTLAFLVPLVEILRRSSSPKPHQVLGLIISPTRELSSQIYHVAQPFISTLSNVKSVLLVGGVEVKSDVRKLEEEGANLLIGTPGRLFDIMERMDLLDFRNLEILILDEADRLLDMGFQKQINAIISRLPKLRRTGLFSATQTEAVEELSKAGLRNPVRVEVQAEMKMLDNPTSSQQQAPSKTPSGLHIEYLECEADKKPSQLVQLLTQNMSKKIIIYFMTCACVDYWGVVLPQISALKRLSIISLHGKMKQTAREKALASFTSLASGVLLCTDVAARGLDIPGVDCIVQYDPPQDPNVFIHRVGRTARLGRQGNAIVFLLPKEEAYVEFLRVRRVPLEERESPDDVCDIVPQIRSAAKKDRDVMEKGLRAFVSYIRAYKEHHCSYIFRWKELEIGKLGMGYGLLQLPAMPDLKHHNLSTEGFTPLEDISLDEIKYKDKSREKQRKKNLQAKKAAEQQQKVQKPKAASTTTATVMRKKTARQRRAAQSVEDDDEMAQEYRLLKKLKRGAINESEFAKLTGTEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V076</accession>
    <name>A0A068V076_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00038141001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V076"/>
    <dbReference type="STRING" id="49390.A0A068V076"/>
    <dbReference type="Gramene" id="CDP13258">
        <property type="protein sequence ID" value="CDP13258"/>
        <property type="gene ID" value="GSCOC_T00038141001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V076"/>
    <dbReference type="OMA" id="NHMAVTG"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V076"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000775">
        <property type="entry name" value="BnaA09g28200D protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045182">
        <property type="entry name" value="JINGUBANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844">
        <property type="entry name" value="F-BOX AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF199">
        <property type="entry name" value="F21J9.19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="457" mass="49802" checksum="D7A5B2CDBFA1C729" modified="2014-10-01" version="1">MKVRSWLRSTCSSSTCISTAKDAIVPPPTPNQLVISDSSSCSDAQASSSASSLTSQDSTYTTRSHTSLESNLSISTLPSVPSLQKLSPEALNLSITTLCITSLKPQQPAHVNFLALNNNLLYAVSGGQVNVFNTTNFTLFDSFHVNNDSSSSGSIKSLAFCDGKIFTAHQDCRIRVWKLTSSSVGQHKLIATLPTVEDRLRNFILPKNYVKVRRHRKKLWVEHYDAVSSLAAAENLLHSVSWDKYLKIWRAKDFRCTESIKAHDDAINAVAASPGGLIYTGSADKRIRVWGRAFGEKKHVLVATLEKHKSAVNALALNFDGSVLFSGACDRSILVWEREESANHMVVTGALRGHSKAILCLINVCDLLLSGSADRTVRIWHRGHDGRYCCLTVLDGHAKPVRSLVAVAEEDSGGAVKVFSGSFDGEIKVWKVMISSSSVKTPIPMSSFQRGSSSLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2N7</accession>
    <name>A0A068V2N7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00042188001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2N7"/>
    <dbReference type="STRING" id="49390.A0A068V2N7"/>
    <dbReference type="Gramene" id="CDP14744">
        <property type="protein sequence ID" value="CDP14744"/>
        <property type="gene ID" value="GSCOC_T00042188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2N7"/>
    <dbReference type="OMA" id="ICIPRVA"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2N7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052306">
        <property type="entry name" value="CYP450_71D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953:SF19">
        <property type="entry name" value="OS06G0641600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953">
        <property type="entry name" value="OS08G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33891" checksum="0CE1C6792D64E9B7" modified="2014-10-01" version="1">MHQLFGSPIHHLLRDLAKKYGALMHLKLGETSTIVVTSPEMAREIYRTNDIIFASRPSQSKEDLVDVLLNIQKRGDFEPQLADTSIRAVILDIFSAGSETSSTAMEWAISEMIKNPEIMKRAQQEVRNFYNDKGNVDESRLHELKYLHAIIKETLRLHPSAPLLLPRECGQECKINGYDIPAKAQIIVNAWAIGRDSNYWSEAEKFNPSRFLDSEIDYKGNNFEYIPFGAGRRICPGISFSQAVIELVLAQLLFHFDWKLPGDLKPEEFDMAEKLGRTIRPQNDLLLIPIPYSASCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2Q1</accession>
    <name>A0A068V2Q1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00042636001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP15075"/>
        <property type="gene ID" value="GSCOC_T00042636001"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="A0A068V2Q1"/>
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        <property type="component" value="Chromosome VI"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044559">
        <property type="entry name" value="WOX13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46777">
        <property type="entry name" value="WUSCHEL-RELATED HOMEOBOX 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46777:SF5">
        <property type="entry name" value="WUSCHEL-RELATED HOMEOBOX 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="246" mass="28257" checksum="709CABA687174548" modified="2014-10-01" version="1">MEGQNIHGGNLNNGDDMFVKVMTDEQMEILGKQIAAYATICEQLEDLHRALISQNDPSHFMLRNPYLTPLMTTSSLHRIPRRQRWNPTAQQLQILERVFDQGNETPSKEKVKDITAELAKHGQISESNVYNWFQNRRARMKKKQVVVENKKTEPETQMVTESSLEEGEKLKPSEPMIEGQNYCVQKVSAGNSIFSFDEQGMEMQQPLFAIEGFHRGMSPDKAKIHYLLEDMDVNPPGCYDPYIHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V554</accession>
    <name>A0A068V554_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00015582001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739186">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068V554"/>
    <dbReference type="Gramene" id="CDP15649">
        <property type="protein sequence ID" value="CDP15649"/>
        <property type="gene ID" value="GSCOC_T00015582001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V554"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V554"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="2">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="176" mass="19583" checksum="8B51BE1E0509FC98" modified="2014-10-01" version="1">MAEEPVNDTVASPSLASQSNSSVVPLGSSSSGKSSVLEALVRRDFLPRGLDICTRRPLILQLVQTRRKPDGTKWALYWINDFESFAESLVAFACVEGIFFSRSFCAIFWVKNWGLMPGLTFSNKLISWDDGLHCDFACLLYALLRVKLSEEILISEMEGFTVTSPREAMAEAMEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V673</accession>
    <name>A0A068V673_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">At2g35280-like TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017369001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739203">
        <property type="protein sequence ID" value="CDP16240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V673"/>
    <dbReference type="FunCoup" id="A0A068V673">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V673"/>
    <dbReference type="Gramene" id="CDP16240">
        <property type="protein sequence ID" value="CDP16240"/>
        <property type="gene ID" value="GSCOC_T00017369001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V673"/>
    <dbReference type="OMA" id="NDVSHCC"/>
    <dbReference type="PhylomeDB" id="A0A068V673"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040338">
        <property type="entry name" value="At1g67623-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057136">
        <property type="entry name" value="At2g35280_TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33784:SF10">
        <property type="entry name" value="F-BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33784">
        <property type="entry name" value="OS05G0482100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23310">
        <property type="entry name" value="TPR_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At2g35280-like TPR" evidence="1">
        <location>
            <begin position="66"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="234" mass="25975" checksum="0A386F0A1424FB6B" modified="2014-10-01" version="1">MANEQKGSSGTSILSLPTEVLSEVLARVASSSSTDLFRAKLWFVLLLMIQTGRGEFLFHSRVSLTKFEIVPWQKNHKVSSFLKKCRESKNPEALYRKGVVDFFTDNHGDSALECLEEAANSGHADAAYALGIIYIFVGGDELKRKGMRLLSGMKKSGILKGRVKLCRDNLRALLRMIWVKNPVFANPTPICCAMTHDRKTFSWPMDADDVEESTCEGCACDEEIGPICAALPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7E2</accession>
    <name>A0A068V7E2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016661001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739194">
        <property type="protein sequence ID" value="CDP15808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7E2"/>
    <dbReference type="FunCoup" id="A0A068V7E2">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7E2"/>
    <dbReference type="Gramene" id="CDP15808">
        <property type="protein sequence ID" value="CDP15808"/>
        <property type="gene ID" value="GSCOC_T00016661001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7E2"/>
    <dbReference type="OMA" id="GTDHSWA"/>
    <dbReference type="OrthoDB" id="1629067at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7E2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37237">
        <property type="entry name" value="OS02G0567000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37237:SF1">
        <property type="entry name" value="OS02G0567000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="146" mass="15749" checksum="7E46BFEACE425A05" modified="2014-10-01" version="1">MRAVGGPLLCIGDLLSDVGEGDQQAVSGGGSHHPQNLQPLDSDPSLVPSDLPKLFQENYDQLDKALAGTDQSWTALTLKLCTALETGNKVVEFATSHIGLLSEKVEKLERITKQRDSAIEAAKAIQGFLEQNEVFPRENSFAQSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7K3</accession>
    <name>A0A068V7K3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016788001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7K3"/>
    <dbReference type="FunCoup" id="A0A068V7K3">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP15883">
        <property type="protein sequence ID" value="CDP15883"/>
        <property type="gene ID" value="GSCOC_T00016788001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7K3"/>
    <dbReference type="OMA" id="RLPHQEQ"/>
    <dbReference type="OrthoDB" id="1937549at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7K3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="219" mass="23185" checksum="4CD583DFCB1C6734" modified="2014-10-01" version="1">MARTNKYSSINFNDIYEKKVGNNSSSSSSFPSPSSSLSSSASSLTSPNKTIISNSRIHGHMLVLSKPATPKPKPIVVPQNPAPKTPALTKPDKVPDQTGSEPDNISLRPQGRTGSGSPVTLSPLPSPGKPASPLTAPLLKSDRFVPPHLRPGFAGREAKLPGPEAVKGGLGSGRGKGQFGAPNHYGNEFHDPTRFKWGSPEFQWVKNSVKLRSSFLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V882</accession>
    <name>A0A068V882_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00019415001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739222">
        <property type="protein sequence ID" value="CDP16856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V882"/>
    <dbReference type="STRING" id="49390.A0A068V882"/>
    <dbReference type="Gramene" id="CDP16856">
        <property type="protein sequence ID" value="CDP16856"/>
        <property type="gene ID" value="GSCOC_T00019415001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V882"/>
    <dbReference type="OMA" id="MFENGIE"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="3">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP16856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="283" mass="29894" checksum="DAB3937C563E0F68" modified="2014-10-01" version="1">MMYISYILYYRRKKAIHKTTTTDDKRLQNTLKRIGVNAIPAIEEVNIFEEDVVIQFINPKVHASIAANTRVVSGSPQTETMLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLLIDLAMYLFKLLDEFCSPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V960</accession>
    <name>A0A068V960_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00018409001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739211">
        <property type="protein sequence ID" value="CDP16473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V960"/>
    <dbReference type="Gramene" id="CDP16473">
        <property type="protein sequence ID" value="CDP16473"/>
        <property type="gene ID" value="GSCOC_T00018409001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V960"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="160" mass="17854" checksum="CEA4D5397805B3D7" modified="2014-10-01" version="1">MKGLTYGDLQAVVPDSAEEVAMGSDEAAMTDNSSIVYGAGGDLSSRREPLFYTAQSFLFLLRSAEAFLSKPPPFDFSCSFLCSVFNQNLSRPSLFSFLLPAFSPHFHFLAFLSRFLFSHHKLAIAFSFLLFFVFSFLLCRTPHAQNVAAAFFSFFFFSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA76</accession>
    <name>A0A068VA76_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00001853001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739247">
        <property type="protein sequence ID" value="CDP17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA76"/>
    <dbReference type="Gramene" id="CDP17482">
        <property type="protein sequence ID" value="CDP17482"/>
        <property type="gene ID" value="GSCOC_T00001853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA76"/>
    <dbReference type="OMA" id="NTEWWES"/>
    <dbReference type="PhylomeDB" id="A0A068VA76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF187">
        <property type="entry name" value="AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="152"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1164" mass="131962" checksum="C72B654604AE643D" modified="2014-10-01" version="1">MEALGNLALDRGRRYVNLDDNLRSLETKLRRLVGRKTDLESQVTEAERSGTKKRKREVEIWFEEVATVENEFRALKKSIQEGGFLENAIISGDKVAKMDAIVEQLMEQSNHFDGLLLEAFENRGEPRVTTKLFGEMFDRGLKAIWAWLVIDSISNIGIYGMGGVGKTTLAKHIHNHLLNRTQFNVYWITVSQEFSIKKLQDNIAKHLRLDLSYEDDEDSRAAILSRALVKQSVLILDDVWQEFSFEKIGIPLGANKCRVILTTRSLVLCNRISCQRVFEAKTLATNEAWDLFKHTLDPKTVLHEEVEEIAKSVAKRCSGLPLGVVTVAGSMRGVNEMSDWRNALKQLKACSVGHDEMERDVFPILEWSFNRLNECQRNCFLYCSLYPEDYKIKREELIDLFIWAELMSKRGSRSKAFDEGQTILNKLIRLCLLEETKDFKGDDCVKMHDLVRDMALRITHGNSKPESSRDDVPRFLVKSLGQEVTLEQEEWTQDLRAVSFYAQCVFRIIEIPPAWSPNCPKLSTLLLSDVFIKEIPDSFFQHMCGLKVLNLSRCGGITELPNSVSNLVDLTALILGGCGGVRSMPPLGKLKQMRDLDLSSTQIRDLPQDLESSVNLERLNLKDCIHLRSVPPLGKLKQLRDLDLSRTKIEDLPQGWESLVNLERLNLDECGAVRRKIIPKGTFSQFHHLQRLLLPPYGRIQVNDPEVLNQLESFGGCLSFADFYNITRWPKYYNKVYINDILTEDPSFVNEVQEFPKKQLHFHQCKLGRGSNYLPNDMENLIIEDCEGMGIRCLSDVFKNFINLSHLSRLDIKDSAGIEFLWQLSSAAPRDQLEVSYFSPLCHLDWLRLERLPNLVGLFYGESEPYLLPAGTFSSLRQLWISGCHNMKQLFPVQLLQSLQNLETLTVKDCEGLEEIAEDGNGVGQGGGEGIQFTSSEGATAAVPLPKLRWLYLNGLPQLKSICKAAMICDSIYEIKIFGCPNSKRLPLFLSTIDGPSYLLPTGTFSSLRELWISGCHNMKQLFTVQLLQSLQNLEELDVTNCDHLEEIAADDDGVGQGGGEGIQLTSSEATATVVLPKLGWLGLENLPQLKNICKAAMICKSIWSINILDCRNLKRLPWFLSTIDGPPSPPSTLEIIGEKEWWESLEWDNSYPKDALDPLFSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA84</accession>
    <name>A0A068VA84_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00000828001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739246">
        <property type="protein sequence ID" value="CDP17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA84"/>
    <dbReference type="FunCoup" id="A0A068VA84">
        <property type="interactions" value="895"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VA84"/>
    <dbReference type="Gramene" id="CDP17469">
        <property type="protein sequence ID" value="CDP17469"/>
        <property type="gene ID" value="GSCOC_T00000828001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA84"/>
    <dbReference type="OMA" id="IFGMCPK"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA84"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000010">
        <property type="entry name" value="Transcription termination factor MTEF1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF78">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="235" mass="26819" checksum="14E06256EA142118" modified="2014-10-01" version="1">MGVDSGKALSQNPCLHTTSLDSIHSIITFLESKGIHQKDLGRIFGMCPKILTSDIKTELNPVFNFLSYDLRVPDQHYRKVINKCPRLLISSVRDQLKPALFYLQRLGFRSLHALAYQDPVLLVSSVEKTLIPKLDFLVSIGFSRADAVGMVLRCPGLFTFSIENNFKPKFEYFAKEMEGSLEELKEFPQYFAFSLEKRIKPRNIAALEKRVKLPLPLMLKTTDEEFEELTRQGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAD0</accession>
    <name>A0A068VAD0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Auxin-binding protein T85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00011475001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This is probably a receptor for the plant hormone auxin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739250">
        <property type="protein sequence ID" value="CDP17524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAD0"/>
    <dbReference type="FunCoup" id="A0A068VAD0">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAD0"/>
    <dbReference type="Gramene" id="CDP17524">
        <property type="protein sequence ID" value="CDP17524"/>
        <property type="gene ID" value="GSCOC_T00011475001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAD0"/>
    <dbReference type="OMA" id="VPINDPH"/>
    <dbReference type="OrthoDB" id="2013851at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAD0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010011">
        <property type="term" value="F:auxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000911">
        <property type="term" value="P:cytokinesis by cell plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032877">
        <property type="term" value="P:positive regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009826">
        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02220">
        <property type="entry name" value="cupin_ABP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000080">
        <property type="entry name" value="Auxin-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000526">
        <property type="entry name" value="Auxin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37236">
        <property type="entry name" value="AUXIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37236:SF1">
        <property type="entry name" value="AUXIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02041">
        <property type="entry name" value="Auxin_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00655">
        <property type="entry name" value="AUXINBINDNGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600526-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600526-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP17524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23109" checksum="6697AA201CD6168B" modified="2014-10-01" version="1">MSITDIIFALQDSFSVSPFMFFGFRSDFFFWGKRSDFVRLPLVRNISELTQNSYGRPGLSHMTIAGSLLHGMKEVEVWLQTFAPGSHTPIHRHSCEEVFVVLKGGGTLYLASNSHSKYPGNPQEFPIFSNSTFHIPVNDAHQIWNTNKEEDLQFLVIVSRPPVKVFIYDDWHMPHTAAKLKFPYYWDEECYLMPPTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAW0</accession>
    <name>A0A068VAW0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00001438001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739257">
        <property type="protein sequence ID" value="CDP17702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAW0"/>
    <dbReference type="FunCoup" id="A0A068VAW0">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAW0"/>
    <dbReference type="Gramene" id="CDP17702">
        <property type="protein sequence ID" value="CDP17702"/>
        <property type="gene ID" value="GSCOC_T00001438001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAW0"/>
    <dbReference type="OMA" id="LPIHEHH"/>
    <dbReference type="OrthoDB" id="1912023at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAW0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000097">
        <property type="entry name" value="Histone acetyltransferase HPA2 and related acetyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF20">
        <property type="entry name" value="GCN5-RELATED N-ACETYLTRANSFERASE 10, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="292" mass="33748" checksum="57EF9C8D8E124A2E" modified="2014-10-01" version="1">MAYLQPNYLSIWSRRCHTENQHYFSLLKINRRWKNSVEKARITKLKRPSGEERRVVWKVHCRSTSNSSSVNEVELAAGQLEVEGNTCYLYNRRDGFGSLLSEHGWHIRRMVETDEEMRKVAGVQAEAFHEPVVLFNDFFFAFFQAEVLSGLLYRLRNSPPDRYACLVAEPSRDSSGSNMDDLVGVVDVTVSRDDDVLQYISGADEYLYVSGIAVLNNFRRKKVATALLKACDRLCNLWGFEYLVLRAYEDDWGARELYSNAGYRVVSGDPAWLTTWVGRRRRVLMIKECDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCL4</accession>
    <name>A0A068VCL4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00012411001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739340">
        <property type="protein sequence ID" value="CDP18580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCL4"/>
    <dbReference type="STRING" id="49390.A0A068VCL4"/>
    <dbReference type="Gramene" id="CDP18580">
        <property type="protein sequence ID" value="CDP18580"/>
        <property type="gene ID" value="GSCOC_T00012411001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCL4"/>
    <dbReference type="OMA" id="TMTIKRT"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCL4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000002">
        <property type="entry name" value="Subtilisin-like protease SBT5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655646" evidence="8">
        <location>
            <begin position="26"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="225"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="11">
        <location>
            <begin position="681"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP18580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="796" mass="86903" checksum="D888ADEBB807142B" modified="2014-10-01" version="1">MSHAFQHSWGLSLLLSLYLISSVSTSHVYIVYLGHNQNKAPDLTSKHHLQLLSTVFTSKKDAKQAMLYSYKHGFSGFSATLNSTQAQVLSNTKGVISIFKSKTVHLHTTRSWDFLGLSMDYSTEKATPMWQQAYGGDVIVGVFDTGERFSYSFQTYLILSIWTESHSFREEPGMGPVPAWWKGKCVSGEHFDPATACNRKLIGATYYLGGFERRYGKLNKTRNLEYESPLDAVGHGTHVASTAVGSVVKNASFLGGFGQGTARGGAPRARLAVYKVCWNVNLEGRCTEADIMAAFDQALRDGVNVISGSFGLRPPLRAFFATAASIGSFHAMQMGVSVVFSAGNSGPDPSLVENVFPWSISVAASTIDRSFPTRIVLDCALSFLGEGFVAHPITAILSNASNYFSSGVCRTESVKNVTAKADGKIILCFSSMGSVRRDEAEAAARNRSAAGLIFVEPLSRPFPDITILPLLLLDIIQGTKMAQYLSRSIDRPPTIQIFPSKTVLKRAPAPIVADFSSRGPSSISPDFLKPDISAPGINILAAWPPMSPPTPTLDDRRSVDWNFQSGTSMSCPHVSGVVALLKSAHPDWSPAAIRSALMTTAYTTDTSNDQILAVGSIKASDPFDIGAGHINPLRAMDPGLVYEMKPEDYLVFLCNIGYTEDQIRSLVLHDMNRRGRTSNANLNYPSITVLNLQRTTTITRKVRNVGGWEKIAVYFVRVVNPQGVDVVVWPKLLIFSPFKQERTFYVTLIPNKISQGRYDFGEIVWSDGFHHVRSPLVILVNTAAVGGHGFQAIANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDZ7</accession>
    <name>A0A068VDZ7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012077001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739364">
        <property type="protein sequence ID" value="CDP18754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDZ7"/>
    <dbReference type="Gramene" id="CDP18754">
        <property type="protein sequence ID" value="CDP18754"/>
        <property type="gene ID" value="GSCOC_T00012077001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDZ7"/>
    <dbReference type="PhylomeDB" id="A0A068VDZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44843">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44843:SF14">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="156" mass="17672" checksum="927BDF7717BAC391" modified="2014-10-01" version="1">MISGQSFDRFGNNTFDFAFFGLRISLDFVLVDQPFEIVSEVCRILRYGGYLVVDITVKDEYGFNSFLTLFTCCGLTIFRGIKSLNSTSSIHEEVKMWAAYGLLKGHISNSILDDIVQRCDNNTVLEYKQDLIGDLEPLEDWTEHGKQGGSPVHQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEB2</accession>
    <name>A0A068VEB2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00000516001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739424">
        <property type="protein sequence ID" value="CDP19066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEB2"/>
    <dbReference type="Gramene" id="CDP19066">
        <property type="protein sequence ID" value="CDP19066"/>
        <property type="gene ID" value="GSCOC_T00000516001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEB2"/>
    <dbReference type="OMA" id="IIYKTDW"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEB2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP19066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="485" mass="53424" checksum="5B2B399DC5B9FECD" modified="2014-10-01" version="1">MDNGLQERLLSSGKEEVVNLKGRIADESKKIWKVALPGILARVSSFGCIVVTQSFVGHISELDLAGYALVQTLSVRFVNGILIGMSSATETLCGQAFGAGQLHMMGIYLQRSWIVDFITLSILLPVFIFGTSIFRLLGEKDDIAQAAGYTSLWFIPFIYNFVFSLTIQMYLQAQQKNMVIAWLSILQFIIHIPLSWLFVYQLDWGVGGAMGALSISSWFVVFGEFAYIFGGWCPDSWKGFTTAAFKDIWPVVKLSIASGVMVCLELWYNAVLVLLAGYMKNAEVAISAFSICLNINGWEFMISLGFLGAACVRIANELGRGDAKATKFSIKVLLSTSIVIGLFFWVLCLVFGSKIGYLFSEEKEVAESVSDLSLLLAFSVLLNSIYPVLSGVAVGAGLQSTVAIINLCCFYLIGIPIGALLGYAAHLQVKGIWIGMLCGVITQTIAICFMTWRTDWDVEVIRAKNRLQRWYLRSPEESNGRSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF45</accession>
    <name>A0A068VF45_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00012319001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739530">
        <property type="protein sequence ID" value="CDP19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF45"/>
    <dbReference type="FunCoup" id="A0A068VF45">
        <property type="interactions" value="3279"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VF45"/>
    <dbReference type="Gramene" id="CDP19346">
        <property type="protein sequence ID" value="CDP19346"/>
        <property type="gene ID" value="GSCOC_T00012319001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF45"/>
    <dbReference type="OMA" id="DIQAGHF"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF45"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="67"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="405"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="699" mass="78559" checksum="0DA353C05971806E" modified="2014-10-01" version="1">MSPVSLRHRKNSKSFATAAARQPPPPDSSPPPSSQPRLQTLARRFWKVAAPYWYSSDDKVQARWRLLAVFALTLGTTGISVGFNFLGRDFYNALANKDQEQFTKQLLYYLAGFAGGIPFFVLRDYARDTLSLRWRSWMTSYYMERYLKNQTFYKIQSQSILDNPDQRIVDDLSSFTGTALSFSLTLFNAAVDLISFSNILYGIYPPLFAVLLVYSVAGTAISIFLGKDLVTLNFLQEKKEADFRYGLVRVRENAESIAFYGGEGNEMQLLLQRFRSAFENLTQLLISSRNLEFFTNGYRILIQVLPVAVVAPMYFSGKIEFGVINQSVSAFNHILGDFSLIVYQFQAISAFSAIIDRLGEFDDVLDSQNIKGRSESMERILINFCSISAMETLETNGSFSLDKSVKLLDVEHLTLQTPMSGTTLIRDLSVEICENDHLLVAGPSGSGKTSLLRALAGLWNSGHGKITFYVKDTRDPQSSISQELASCVVASTHETDGNLHSLRQGSTRSLFFLPQKPYMVLGTLRQQLLYPTWTEDPTSALDAPKSTAMLPFLIRTPIINRQSMRPSPPTNDDLRRVVEDVGLGYLLSRCNSLDSVNEWSSVLSLGEQQRLAFARLLLSKPYLALLDEATSALDEANEANLYRKIGAAGITYVSIGHRRTLYNYHTRVLHISTAEPLSIQRNWNIEPINPERVYNLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFN4</accession>
    <name>A0A068VFN4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00006175001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739657">
        <property type="protein sequence ID" value="CDP19625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFN4"/>
    <dbReference type="STRING" id="49390.A0A068VFN4"/>
    <dbReference type="Gramene" id="CDP19625">
        <property type="protein sequence ID" value="CDP19625"/>
        <property type="gene ID" value="GSCOC_T00006175001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFN4"/>
    <dbReference type="OMA" id="MFILTVH"/>
    <dbReference type="OrthoDB" id="1920188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="HEAT SHOCK PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670:SF34">
        <property type="entry name" value="HSP20-LIKE CHAPERONES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="8">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP19625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="294" mass="34014" checksum="ED238F1F21A7DDD9" modified="2014-10-01" version="1">MDLELGLKLRRVADEFCLADFQFYKDRTGPVFISTETDSKFFLTAHLKGHRKQNIKIEINEDGTRIIISGEMEIQETVMVEWRLYRKETEIRRFRKAFKIPDGVILDKIKAKYNADECILTISMPKKDKGIRGFDIEEVQEQELAREGSETLEIVPDEVPKQEDEMQAKDQEAEAEHAEGKLEKEEKSQGIEGDMERKHEQPEPLTEVIDQNHHKRDQVDGKESGTQEAEEEEESALVKPPDEVQEDRPSRIEKHRGRCKMCAPILAGSALLLSLVVFVIQFIRKKSHQGKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGH7</accession>
    <name>A0A068VGH7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00005557001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739372">
        <property type="protein sequence ID" value="CDP18783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGH7"/>
    <dbReference type="FunCoup" id="A0A068VGH7">
        <property type="interactions" value="1928"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGH7"/>
    <dbReference type="Gramene" id="CDP18783">
        <property type="protein sequence ID" value="CDP18783"/>
        <property type="gene ID" value="GSCOC_T00005557001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGH7"/>
    <dbReference type="OMA" id="PHEDHFV"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035825">
        <property type="term" value="P:homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009556">
        <property type="term" value="P:microsporogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000033">
        <property type="entry name" value="Binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF3">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP18783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="98115" checksum="82062ADCD6B01449" modified="2014-10-01" version="1">MTDKMSAERELEEQLKEAGGKLLQPPSSLDELLPLLDQVENFLSRVEQSPAKSMQAALSPLTNALVTDELLRHENVDVKVAVASCVSEITRITAPDAPYDDDKMKDVFQLIVSSFEGLSDESSRSYNKRALILETVAKVRSCVVMLDLECDGLIAQMFQLFLGAIRDYHPENIFSSMETIMTLVLEESEDISSEILNLLLANVKKDNQEVLPVAMKLAEKVFENCAVKLKPYLSQAIQSLGCSLDDYSEVVTAICEGPSSTEHTNENASTEQQVAKDVNEAYSGDADHDVNRSPKSIMLNGGDDLGNDNKGTVIGAQSSVNVKEHDLEDEPSADKVAMKPEIADSETRESVMLESKLEDAAMKRERKPSSSINVSESSDTSHIDGEKEVEKLPDLQDSREKDLRGSPREELSAETSKSLDRDIVAKPSSPKTSETEDANTASASLSGSLDDAVRPKKASRLKKKEISIQQETLSSDVSKKASEGRNDSEAKPHRRLGKKAPVDTDNEDKMSADVDTSEDGGGGKSDSETKQMKQARKKVDESSNAGDGYSLKRNGESKKRVRGKAASENEGTKTSAKDDLKQQTHKSPTRSAKDEGSSEETVRMSTKRKRTASKDKGTADVEYGSNLVGLKVKVWWPHDRQFYEGVIHSFDSAKKKHKVAYNDGDEEILNLKKERWELVDDGSVSSEEQGAETAIPDTASGMQRRKKGRRNPESSIKPGKKEVSPKSGAASSGKAKGTATKSGHKTEDDQKLKDRTTKSVAKSEDDSTGKAKSQRTGDKHPDDFTKTSVKSKDVDTSTPKAKSKQDIPKTGSMSKQDTPKTGIKSKSKTPQAGGDGSANGTGKIKHSSSKMKETEDLKERSKDKSTDVLKTPEGVKVKSSEASKVQEKNQSVKKRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGM4</accession>
    <name>A0A068VGM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00009407001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RING-type zinc finger family. LOG2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HG739830">
        <property type="protein sequence ID" value="CDP19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGM4"/>
    <dbReference type="FunCoup" id="A0A068VGM4">
        <property type="interactions" value="1210"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGM4"/>
    <dbReference type="Gramene" id="CDP19876">
        <property type="protein sequence ID" value="CDP19876"/>
        <property type="gene ID" value="GSCOC_T00009407001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGM4"/>
    <dbReference type="OMA" id="NGWPAIR"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16789">
        <property type="entry name" value="mRING-HC-C3HC5_MGRN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000115">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase LOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045195">
        <property type="entry name" value="LOG2-like_mRING_C3HC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LUL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="297" mass="33176" checksum="E35742172F4DAC77" modified="2014-10-01" version="1">MGAQSNYHNPYYVGGQGSGWFRPPQAAMLLAPSPHLQPPPPAPVPYVDHQSAKKIKNDVNVHKDTIKLEVDEGNRDCHLVSFTFDAMVDGSITIYYFAKEGTKCTFNPVHPEMYVPMKIPFQKGLGQKFCQPSGSGIDLGFFDIDDLSKPSAGDVFPLVISAQSCLSSTLMEDQLNEEAVNTSPHAQITQAVIEKNNDDHFQVKVIKQILWIEEIRYELREIFGISNSDEQAINDKDLGKECVICMTDPKDTAVLPCRHMCMCSECAKELRLQTNKCPICRQPIEELLEIKVDEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH67</accession>
    <name>A0A068VH67_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00009260001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739868">
        <property type="protein sequence ID" value="CDP19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH67"/>
    <dbReference type="Gramene" id="CDP19919">
        <property type="protein sequence ID" value="CDP19919"/>
        <property type="gene ID" value="GSCOC_T00009260001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH67"/>
    <dbReference type="OMA" id="YEETHYY"/>
    <dbReference type="OrthoDB" id="1896560at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH67"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="236"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="9">
        <location>
            <begin position="448"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="804" mass="91745" checksum="E88099055937B7BC" modified="2014-10-01" version="1">MGGLGKTTLAKLIYNNKQIDGHFDIKIWVCVSKKVPIEELFKLILVQLTKEKVEVDDRNVIVGKIRNQLEGKRYFLVLDDVWDDNQALWDDFFTTLKGLNPTNVSWCLVTTRLGPVAHSVSRVLRMMENERYPLGKLPDDHCWSIVKEKVVGGEEEPDELKAIKERVIKRCDGLPLAASVIGGLLSLKRKEEWRSILENRLSSLSGDGDGVMQILKFSFDNLPSPYIKKCFAYWSIFPKDTQMRGDKLIELWMAEGFLQADINSQMMMEEIGMNCLRILLQSSLFEETRSYEETHYYKMHDLVHDLAESMSKSTKVINNGDAQIIDNSNQIRYLALKNLYVLDLSDATTQELPASIGKLIHLRYVNLSWSAISILPDSLCKLYNLQTLMLSYSEVKVLPKGMCDLISLRHLHYEDNYKVFQMPLEMGRLTCLQTLEFFKVGREKGRRIGELGSLKNLKGRLEIRNLELVTDKEGAEEAKLSEKANLLRLQLKWAQDREGHDYNDKDVLDGLQPHPNLEELVIENFMGDQFPRWLMDLPTTTTLPELATTPPKLACLKFNRCNRCRELLPLQKFTSLKELKIWNCDGLTNLPGDMLHSCASLQKLSVADCDNLISFPLDLQQTPSLLELGLYRCPKLKTSMTPKGFGFLTSLRELVIGPFSDDGDDHENSSIYNEFDWSGLISSSSSSALRRLELFGLPHMESLPHQIQYLTTLTSLTLRDFGGIKALPDWFGNFAALEELRLFDLKELGHLPSEDAIRSLPKLKLLRVCRCPLLKERCTPASSGPDSQWSKVSHIQDLQITDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIN6</accession>
    <name>A0A068VIN6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_1499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00005359001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG740583">
        <property type="protein sequence ID" value="CDP20660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIN6"/>
    <dbReference type="FunCoup" id="A0A068VIN6">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VIN6"/>
    <dbReference type="Gramene" id="CDP20660">
        <property type="protein sequence ID" value="CDP20660"/>
        <property type="gene ID" value="GSCOC_T00005359001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIN6"/>
    <dbReference type="OMA" id="THHYIMS"/>
    <dbReference type="OrthoDB" id="1886868at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01959">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34128">
        <property type="entry name" value="CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCME HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34128:SF2">
        <property type="entry name" value="CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCME HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="Heme chaperone CcmE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP20660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="291" mass="32648" checksum="FDAB87E548026B61" modified="2014-10-01" version="1">MYSRVASHLLRRLRPAATTTTTFLRHHNYPNSFSTTTTTTTFFSKSHPIFSLYPPGHYNLSPNLRFFSTRPARPVRPNRPDIGARARQLQTRRLWTYALTFSCIAGFIVIVLNQFQDQLVFYVTPTDALAKYSQNPSKSKFRLGGLVLEGSLTQIPSSPEMEFVITDLMTDILVKYEGSLPDLFREGHSVVVEGFIRPFPEKEKDEDVSREGSSSSSSIHGKAFMVSEKARSGECYFKATEVLAKHDEKYMPPEVATAIEKNKKVLIQEQQQQQESEGKGAGDGAVGTAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ63</accession>
    <name>A0A068VJ63_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_1489</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00011924001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740573">
        <property type="protein sequence ID" value="CDP20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ63"/>
    <dbReference type="STRING" id="49390.A0A068VJ63"/>
    <dbReference type="Gramene" id="CDP20657">
        <property type="protein sequence ID" value="CDP20657"/>
        <property type="gene ID" value="GSCOC_T00011924001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ63"/>
    <dbReference type="OMA" id="HAYNIMH"/>
    <dbReference type="PhylomeDB" id="A0A068VJ63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF824">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="158" mass="18002" checksum="85C69C07D0D597E2" modified="2014-10-01" version="1">MTDSEFHFFYFELFCPFALFTRGKVGLSHLMYLHAYNIMHGDIKLDNLLVTASGTVKIGDFGIKIVFLFDDNGELHHSTGTSIFTTPECYSGSCMTDAENMLNLRLHFWILTKLPGLIYLHLYFSQIVNNLLYIPDGMNPLLKSSIEGHFCKGLSLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK16</accession>
    <name>A0A068VK16_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DH200=94 genomic scaffold, scaffold_833</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00010749001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739917">
        <property type="protein sequence ID" value="CDP20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK16"/>
    <dbReference type="STRING" id="49390.A0A068VK16"/>
    <dbReference type="Gramene" id="CDP20018">
        <property type="protein sequence ID" value="CDP20018"/>
        <property type="gene ID" value="GSCOC_T00010749001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK16"/>
    <dbReference type="OMA" id="HISCVEM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF255">
        <property type="entry name" value="CYTOCHROME P450 72A11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="487" mass="55413" checksum="E1884AA361B7472A" modified="2014-10-01" version="1">MEVSTSYMLVPVLGLLGYVIYCFYNLLEMYWLKPKRLEKCLRKQGYKGSPYRLRGDPYEKKLIGEALSKPIGLNENIVKRTMAHLINTVQTHESFSGLGALEGEPWVKRRRILGRAFHVEKLKLMLPAFHISCVEMLSRWESMVSGKGSMEVEVWREIKDLTGEMLSRTLFGTRFAEAQRILEIINEIAALTMDAISSTYIPGLRFLPTKRNSRLRALDRELRARVQVIIDQKRKAIIAGEASGDDFLGILVESNLNALKGNNKGEVLTDQDVITESRLFFFGGQETGTNLIVWTMFLLSRVPDWQQRAREEIFQVFGDKMPTYDGLNGLKTSIFSSHSSYSTRLQVTMILNEVLRLYCLVPEVSRVSAEDTTLGEDFIPAGVEFQMPQVLVHYDPEYWGDDVLEFKPERFAEGISKATNAQGAYFPFTLGVRVCIGDNFVLLEAKMAMLLILRSFALELSPSYVHAPINRITTNPQYGVHLILRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKC2</accession>
    <name>A0A068VKC2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_2413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00010005001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741497">
        <property type="protein sequence ID" value="CDP21067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKC2"/>
    <dbReference type="FunCoup" id="A0A068VKC2">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VKC2"/>
    <dbReference type="Gramene" id="CDP21067">
        <property type="protein sequence ID" value="CDP21067"/>
        <property type="gene ID" value="GSCOC_T00010005001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKC2"/>
    <dbReference type="OMA" id="CHHKMQY"/>
    <dbReference type="OrthoDB" id="1931703at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKC2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000286">
        <property type="entry name" value="Dihydrodipicolinate reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000074">
        <property type="entry name" value="Dihydrodipicolinate reductase, C-terminus family protein, expressed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="DIHYDRODIPICOLINATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836:SF6">
        <property type="entry name" value="DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydrodipicolinate reductase N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydrodipicolinate reductase C-terminal" evidence="9">
        <location>
            <begin position="174"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP21067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="304" mass="32407" checksum="0B37D46A243B7100" modified="2014-10-01" version="1">MAALSCHSQPISYTTSLQNVKKIVAPSISCSMQPGGQSNIKVIVNGAAKEIGRAAVVAVTKARGMGVAGAVDSYLVGEDIGKVCDMEEALEIPIMNDLTMVLGSISQSKGMAVVVDFTDPTTVYDNVKQATAFGMNSVVYVPRIKQDTVMALSSFCEKASMGCLVAPTLSIGSILLQQAAISASFHYNNVEIVESRANAADFPTQDAIQIANNISNIGQLYNRQDISTEVQARGQVLGEDGVRVHSLVVPGLPSSTTVYFSRPGEVYTIKHDITDVQSLMPGLILAIRRVVRLKNLVFGLEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLU9</accession>
    <name>A0A068VLU9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00010954001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="HG740566">
        <property type="protein sequence ID" value="CDP20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLU9"/>
    <dbReference type="STRING" id="49390.A0A068VLU9"/>
    <dbReference type="Gramene" id="CDP20653">
        <property type="protein sequence ID" value="CDP20653"/>
        <property type="gene ID" value="GSCOC_T00010954001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLU9"/>
    <dbReference type="OMA" id="IICCACK"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLU9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="290" mass="32868" checksum="8D1BA46B73D176E8" modified="2014-10-01" version="1">MGNNLATPARPLQSQDPTNEDEPPPPLPPQQLPLSPLPQPPPQLPQENQPSTCEICIEPIISPTQLFKSPNNDKCGPHPFCKDCMIRYIQAKLDDNVSKIACPALNCSQFLDPQACRTLVGPQLFVKWCDSLCESAVMGFPRSFCPNRNCSALIVNECGGTVKKATCPCCKRLFCFQCKLPWHAGFRCEESGEFRDRNDRAFGVLVEQKNWMRCPQCQHFVELIEGCQIVKCRCLASFCYKCGRQVYQHWCTCDSTSMCCVWFLRIFTVLIGVFGVLFLFWNTESRKHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN53</accession>
    <name>A0A068VN53_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_10692</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00000732001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG749776">
        <property type="protein sequence ID" value="CDP22121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN53"/>
    <dbReference type="Gramene" id="CDP22121">
        <property type="protein sequence ID" value="CDP22121"/>
        <property type="gene ID" value="GSCOC_T00000732001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN53"/>
    <dbReference type="OMA" id="MASCKSI"/>
    <dbReference type="PhylomeDB" id="A0A068VN53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF587">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658813" evidence="8">
        <location>
            <begin position="31"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP22121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="545" mass="60393" checksum="085C051336C36CF6" modified="2014-10-01" version="1" fragment="single">MWGFRSSSTLANIFLLLFVAMIFSVSHVSASKQFKNETDRLALLEFKKQIYNDPLGVLNSWNHSQHHCQWEGVTCGTRHQRVIALTLRHKQLLRVLNLSSNAIGGKIPANLSYCSELVTISLFENKLEGKIPIDQLSNLKKLEYFNLRTNNLTGEIPSSIGNLSSLTGLAFSDNHVEGKLPVEMGLLKRLVQLFLGENKLSGKIPTSIFNSSAITVISVAGNSFHVMANLSNQLTKLFLGGNQLSGTIPEGFGNFVNLYLLSLEENYLSGVIPRDFGKLQNLQAFENSFTGSLPSEVGKLIHLVDFNVSHNQFSGDISMSLADCSDLENLFMQSNFFRGTVPPNMASCKSIQRLDLSSNNLTGPIPKEFEKLQFLRYLNLSYNDIEGEIPNTGVFSNASQISLIGNNKLCGGIPELELPPCPVIKGKNRGKLKVIILLSIVLPATLLVLGALLLYFLVYRKRERRLVAGFCSMPTRVDMLLRISYHELLRASSGFSSENLIAVKVLDLQKNGASKSFKAECKALRNIRHRNLISIVSYCSSIDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNQ5</accession>
    <name>A0A068VNQ5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DH200=94 genomic scaffold, scaffold_3534</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00009957001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG742618">
        <property type="protein sequence ID" value="CDP21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNQ5"/>
    <dbReference type="FunCoup" id="A0A068VNQ5">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP21353">
        <property type="protein sequence ID" value="CDP21353"/>
        <property type="gene ID" value="GSCOC_T00009957001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNQ5"/>
    <dbReference type="OMA" id="PMAFRFH"/>
    <dbReference type="OrthoDB" id="1879185at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNQ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000005">
        <property type="entry name" value="Germin-like protein subfamily 1 member 8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655996" evidence="11">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="12">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="12">
        <location>
            <begin position="291"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="459" mass="49353" checksum="4E9A757304A4C9F4" modified="2014-10-01" version="1">MAVRIHIAAAILALVFTVVHASDPSPLQDFCVAVPDANAGVFVNGKICKDPKLVKPEDFFFPGLNKPGSTANPLGSNVTAVNVNQIPGLNTLGVSLARIDFAPYGLNPPHIHPRATEVLFVLEGTLVVGFVTSNPGMNMKNKLFTKVLNPGDVFVFPQGLIHFQFNQGHSNAVAFAGLGSQNPGVITIANAVFGSDPPISPDVLTKAFQVGNDVIKKLQSQFWWDNNYPMAFRFHIAAAILALVFTIVHASDPSPLQDFCVAVPDANAGVFVNGKICKDPKLVKPEDFFFPGLNEPGSTSNPLGSNVTAVNVNQIPGLNTLGVSLARIDFAPYGLNPPHTHPRATEILVVLEGTLLVGFVTSNPGMNMKNKLFTKVLNPGDVFVFPEGLIHFQFNKGHSNAVAFAGLSSQNPGVITIANAVFGSKPPISRDVLTKAFQVDKNVVKYLQSQFWWDNHYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VP22</accession>
    <name>A0A068VP22_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_4234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012268001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG743318">
        <property type="protein sequence ID" value="CDP21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VP22"/>
    <dbReference type="STRING" id="49390.A0A068VP22"/>
    <dbReference type="Gramene" id="CDP21458">
        <property type="protein sequence ID" value="CDP21458"/>
        <property type="gene ID" value="GSCOC_T00012268001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VP22"/>
    <dbReference type="OMA" id="PYETARV"/>
    <dbReference type="OrthoDB" id="1720310at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VP22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000003">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590">
        <property type="entry name" value="OS03G0124300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590:SF5">
        <property type="entry name" value="OS04G0586500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001659043" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="14334" checksum="D862BE78C24C8319" modified="2014-10-01" version="1">MFTLLVYLCFLFNLLLVIASTGSTPPYTPTDYILISCGSSSNSTSVDGRKWDGDVGSKFSPNDMANISSAVTATELGPSVSRAPFSSARIIRSQFSYTFPVSLGKKFLRLYFYPTSYSGGLNTTESFFNVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VR24</accession>
    <name>A0A068VR24_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_11444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00011347001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG750528">
        <property type="protein sequence ID" value="CDP22168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VR24"/>
    <dbReference type="STRING" id="49390.A0A068VR24"/>
    <dbReference type="Gramene" id="CDP22168">
        <property type="protein sequence ID" value="CDP22168"/>
        <property type="gene ID" value="GSCOC_T00011347001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VR24"/>
    <dbReference type="OMA" id="DKWEDRK"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VR24"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP22168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="51" mass="5871" checksum="B67E6D9E267749DC" modified="2014-10-01" version="1" fragment="single">GLWSGMLGGTVMQTIILLWVTVRTNWTKEVEAALKRLDKWEDRKKEALLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKU8</accession>
    <name>A0A068TKU8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00013966001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKU8"/>
    <dbReference type="Gramene" id="CDO96821">
        <property type="protein sequence ID" value="CDO96821"/>
        <property type="gene ID" value="GSCOC_T00013966001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKU8"/>
    <dbReference type="OMA" id="TIPENMC"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKU8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF73">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="804"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO96821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="857" mass="94267" checksum="40B22DF628D94C13" modified="2014-10-01" version="1">MGLTGTIPRQLGNLSFLVTLDLSGNKFQGSLPQEIVYLHRLRVINLSFNNFTGQIPSWFSFLTCLKYLNLKKNNFTGLIPYSLSNLLKLENLILSSNSIQGIIPEEIGNLHSLKYVDIENNQLNGSIPSSAFNISTLETIALGQNSPFGNLPTDVCLNLPKLKKLKIWNLTTLELLYLGDHNLRGRYNFIFISRLDPNNLYLHDNQIMGSIPASIFNISSLTVISLKVNKLNGTIPENMCHRLPNLEGLYLYGNLLRGQIPTGLHECLALQEFTLEENELTGTIPRAIGNLTFLTRIYLGHNKFTGTIPQEVGNLRKLEDFSLVFNSITGPIPVEIFNISTLVFLSLVGNHLSGNLPSSMGGRLPNLETVYVYLNDLDGVIPPSISNASKLAYLNLSGNKFSRSIPTSFGDLKHLKILDFSVNNLLSEPSSSELSFITSLTNCKILTRLGMNDNPLNGSFPLSIGNLSSSLERIYAYNCDIRGNIPQGLGNLSSLVILNLSKNRLTGSFAAAIKGFRDLQGISLNENQLTVAVSEDICALKSLYNLYLSKNQISGSLPSCIGNMTSLRYLSIAKNSLNSSIPTSEWNLDNLLVLDLSSNFFSDILPKEIQNLKAATYISLSANHISGNIRTSIGGLQMLLTLSLAENKLQGFIPDLMGDLSNLVFLDLSNNNLSGLIPKSLVALQFLSYVNLSLNNLWGEIPSDGPFKNFTSQSFMSNGGLCGSTRFLVPPCSTSIGHKSTRKKTSHVIFITSGIGAALMAITLTIVFLMYRNKTEVSRTEGILEIRTVQRISYYELLQATHGYEKSNLLGTGSCGSVYKGILKDGMLVAVKMLNLQVKISPGSFERECEVFRNVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMV8</accession>
    <name>A0A068TMV8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014553001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068TMV8"/>
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        <property type="protein sequence ID" value="CDO97274"/>
        <property type="gene ID" value="GSCOC_T00014553001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMV8"/>
    <dbReference type="OMA" id="CFASESH"/>
    <dbReference type="OrthoDB" id="651283at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMV8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:root hair initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="bHLH_AtIND_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF274">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO97274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="412" mass="45331" checksum="114CEA4FD549031A" modified="2014-10-01" version="1">MESFGAMGCGDWSSCNAIYSSTTEEADFMARLLGNISLPNDVPNSSNAKFSSTYWPASESDVNKAVFQEDSSINSSDDTSVDADVCYSFSQGSSFSGEGSSILCPLSQIYFCNSNSIISQPIVTRNDSSVCADYAMMECKNKMDSCDHEIIRINNILMEEGRDFLNQDVSSDCSMESGENDMPEAFSRGMILQQGKDQHEINSLASTKSLEDESDNLLESSKKRPSTPLDVHKNKRMINAKTNHQKLHPYDSKIAEGGHPVLCRQSSSSCLSEDDSNVFHESNAGVLPIPASCSDSKGAITAFNLNGKTRASRGSATDHQSLYARKRIEKINERLRILQKLIPNGTKVDISTMLEEAVQYVKSLQLQIKTKTIYFCLSVTKGYHSVCSLLSSDDLWMYAPIAYKGKNLGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNK9</accession>
    <name>A0A068TNK9_COFCA</name>
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        <recommendedName>
            <fullName evidence="2 9">Phospholipase D</fullName>
            <ecNumber evidence="2 9">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00021873001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the phospholipase D family. C2-PLD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="2 9"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNK9"/>
    <dbReference type="FunCoup" id="A0A068TNK9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNK9"/>
    <dbReference type="Gramene" id="CDO97925">
        <property type="protein sequence ID" value="CDO97925"/>
        <property type="gene ID" value="GSCOC_T00021873001"/>
    </dbReference>
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    <dbReference type="OMA" id="DWKVQVF"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNK9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024632">
        <property type="entry name" value="PLipase_D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011402">
        <property type="entry name" value="PLipase_D_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF137">
        <property type="entry name" value="PHOSPHOLIPASE D ALPHA 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12357">
        <property type="entry name" value="PLD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036470">
        <property type="entry name" value="PLD_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="10">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="10">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO97925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="757" mass="86787" checksum="6DCA07D75DE62484" modified="2014-10-01" version="1">MEGKHRFFHGTLEATICHATPRKPSFRFSCVANEKPAYVTIKIGSKKVAETTHEHDRIWNQTFQILCAHPSDTIITIALKTRCSILGKIKILANQLLDGASLINGFFPLCGENGKPNLKLKLQYILWFKPAEYESSWEKVLANDAYHGLKNATFPQRSNCNVILYQDAHHCASFQPPSALSQTPKKLWEDVYKAIEGAKHLVYIAGWSLNPKIILVRDPNTDLPHARGVKLGELLKRKAEEGVAVRILLWDDETSLPIIKNQGVMKTHDEDSLAYFKHTKVICKLCPRLHDKFPTVFSHHQKTITVDTRVQQSSTNREILSFIGGLDLCDGRYDTQDHSLFKTLNTEAHCYDFYQTSISGASLHKGGPREPWHDTHACIAGQAALDVLTNFEQRWTKQFEPSLLVPLSSIPELSNQHSTSISSERDWNVQVFRSIDHVSAIPLPRNMSTERSIHEAYVEAIRRADRFIYIENQYFLGGCHLWERDQQCGCRNLIPVEIALKVANKIKAKERFAVYIVIPMWPEGAPESESVHDILHWLRETMKMMYKLIAEALEESGEPGHPRDYLNFFCLANRENEVKGEFVPPYSPHPETHYWNAQKQRRFMVYVHSKLMIVDDTYMLIGSANVNQRSMDGKRDTEIAIGCHRSKSSEERMDRGDIHAFRVSLWYEHTGQAEEVFQDPRSLECVQRIRSIGEQMWEVYSADEVVDMKRTHLLTYPVNVTKEGCVQDLAEGNYHFPDTRTPIKGKRSKFLSPVFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPT0</accession>
    <name>A0A068TPT0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014702001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPT0"/>
    <dbReference type="FunCoup" id="A0A068TPT0">
        <property type="interactions" value="1968"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPT0"/>
    <dbReference type="Gramene" id="CDO97378">
        <property type="protein sequence ID" value="CDO97378"/>
        <property type="gene ID" value="GSCOC_T00014702001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPT0"/>
    <dbReference type="OMA" id="ETSGAQN"/>
    <dbReference type="OrthoDB" id="782223at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPT0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009631">
        <property type="term" value="P:cold acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033244">
        <property type="entry name" value="MED32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35989">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35989:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15451" checksum="E644EA9C2EC6442C" modified="2014-10-01" version="1">MDNHVDSLNNAYEEFVAAAANVLEAKESSEGQKTAATDAALENFKQRWELFRVACDQAEEFVESVKQRIGSECLVDEATGSVARKPGQAATSGLPPISAVRLEQMSKAVRWLVIELQHGGTAGGSSHSHSSAPFDARFSEDAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQB8</accession>
    <name>A0A068TQB8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00014944001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQB8"/>
    <dbReference type="FunCoup" id="A0A068TQB8">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQB8"/>
    <dbReference type="Gramene" id="CDO97563">
        <property type="protein sequence ID" value="CDO97563"/>
        <property type="gene ID" value="GSCOC_T00014944001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQB8"/>
    <dbReference type="OMA" id="SIWFKIQ"/>
    <dbReference type="OrthoDB" id="122279at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQB8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000287">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase RKF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000542">
        <property type="entry name" value="Receptor-like serine/threonine-protein kinase At4g25390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043891">
        <property type="entry name" value="SPARK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF58">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19160">
        <property type="entry name" value="SPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657216" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="22"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="307"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDO97563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="645" mass="71097" checksum="AA50A16121572C61" modified="2014-10-01" version="1">MKFLILFLVLSFCLSVTKISSLSPVSDNSTSPNICPMDLNYVLRIPWSTRDCRKLSKISDNITSNSGNNPCCQTLISLYGIAFAERLEATNFFQLPNLETSISCLHNFQSKLNALSLSPDLTSFCFDPLQFVISSNVCASIQTTQDWVKTLGPSTVLDSACRPDLTDLTACDACLAAAFQVQSQLIRIDGNKSHSVACFYFAVLYASGIVNEFGPQSNAAISCIFNLQIKSKKDHSSLIFGLTGASVAVLVISVFLGLYLWWAKKRRRGGQSFDLGSEEMESRPRRRPSTVSIWFKIDELLKATDNFSSKNFIGRGGYGIVYKGTLADGTVVAVKKVIESDFQGNDEFCNEVEIISNLKHRNLVPLRGCCVTDEDLTDGHEVSGRYLIYDYMPNGNLDDHLFPTNGGENVKQPLTWPQRKSIILDVAKGLAYLHYGVRPAIYHRDIKATNILLDADMRARVADFGLAKQSREGQSHLTTRVAGTHGYLAPEYALYGQLTEKSDVYSFGVVILEIMCGRKALDFSSGSHHAILITDWAWSLVKSGKMEQVLDSALTKNEDSAIVNPKAIMERYLLVGILCAHVMVALRPTIMDALKMLEGDIEVPAIPDRPAPLLMHPSLHGGDINNFTISPALSALKLNSGDMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRU9</accession>
    <name>A0A068TRU9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-glycerate 3-kinase, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022061001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRU9"/>
    <dbReference type="FunCoup" id="A0A068TRU9">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRU9"/>
    <dbReference type="Gramene" id="CDO98083">
        <property type="protein sequence ID" value="CDO98083"/>
        <property type="gene ID" value="GSCOC_T00022061001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRU9"/>
    <dbReference type="OMA" id="WCEQQIS"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRU9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001210">
        <property type="entry name" value="D-glycerate 3-kinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51124" checksum="B0EA7FA656203E4A" modified="2014-10-01" version="1">MAAVNILWQPTNPGQLTAPSTSPSHSNFNSDIIHTDCYHNNSTNRTAIKSKWAAVPRRALTKVRAKFSPLPSQMLPESSISSGGKSSWIQDNSACGDNFVHNGHRQGPIHSRFPTAPAEVSSVKDLFDFICSGPLLDKFGLTTEKVAESIDKWLLYGSKLCRLFQLDELYMTEPQKVRIYHYYVPVFLWCEDEISQHMSTFNEGEDIPPLVIGFSAPQGCGKTTLVFALDYLFRITGRKTATLSIDDFYLTAESQAKLRESNSGNALLEFRGNAGSHDLSLSVETLTALSKLTKEGLKMKLPRYDKSAHNGRGDRADPSTWPEVEGPLTAVLFEGWMLGFKPVPAETVKAVDPQLETVNKNLEAYYDVWDRFVNSWIIIKIQDPNYVFRWRLQAEIAMRADGNPGMSDEEVMDFVSRYLPAYKAYLPTLYAEGPKGSDPKHVLVIEIDEGRNPILGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRW9</accession>
    <name>A0A068TRW9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00026074001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068TRW9">
        <property type="interactions" value="1438"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRW9"/>
    <dbReference type="Gramene" id="CDO99055">
        <property type="protein sequence ID" value="CDO99055"/>
        <property type="gene ID" value="GSCOC_T00026074001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRW9"/>
    <dbReference type="OMA" id="DGNLHDQ"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRW9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054292">
        <property type="entry name" value="DUF7028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46508:SF3">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASE WITH RING_FYVE_PHD-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46508">
        <property type="entry name" value="PHD FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22970">
        <property type="entry name" value="DUF7028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="651"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="963"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO99055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1388" mass="152674" checksum="61711E8718E865DB" modified="2014-10-01" version="1">MEESVRSGGVLKKKSSSGCLIIKKKAEVLGSAGSSHKEKKRPRLINSDSGRGEEEMGLRRNGDIIESDRKRSRLDLFDFDEYDEFDGKRMRNDYREMGSGNSREFGGGSSRNMMVEKRSKMYFDRSGGGVSGRNKVVDYGGERRFVLEDDEAHLPISLLRLKYPEEPAEPIRLQGKNGVLKVMVNKKKNMELPLRKTYDLQEVENRKGSKSEDVVKKEPSVPPTFYSDSKRADKRIAFVERERSQLKLQKPLLGKSNKTGDYAGENRELKLQKPLCGKSPKAREYESDGSDTSLKLAPPSLQAGSSKKAVKRETKGSLATENVPLDKGREHKVTPPAENATPVKGIDAKLKRGGSTEKQLLRERIREMLIKAGWTIDYRPRRNRDYLDAVYINPGGTAYWSIIKAYDALQKQLQEEDGDSKPDGVSSSFAPLSDDLINKLTRQTRKKIEEEMNKKRMDDGLTQNSKKVSAKASREDSDSDQNDEKLSSFIRQNGKPKKGKLHEVKSKIQGRKSRKIGRCTLLVRSSDMGQNSESDGYVPYTGKRTLLAWLIDSGTVQLSEKVQYMNRRRTRVKLEGWITRDGIHCGCCSKILTVSKFELHAGSKLRQPFQNIILESGPSLLHCLIDAWNRQEESMRRDFYVVDVDGDDPDDDTCGICGDGGDLICCDGCPSTFHQNCLGIQMLPKGDWHCPNCTCKFCGTASGNLNEENATPSELFTCILCEKKYHKSCTEEMVSPLANANSPLSFCGKKCQELYDQLQKILGIKHELEAGFSWSLLQRTDLESDTASRGFPQRVECNSKLAVALSVMDECFLPIVDRRSGINLIHNVLYNCGANFSRLNYHGFFTVVLERGDEIISAASIRIHGLQLAEMPFIGTRNIYRRQGMCRRLLSAIESVLCSLKVEKLIIPAISEHMHTWTVVFGFKQLEDPDKKEMKSINMLVFPGTDMLQKQLFKQGIPGGLKGFDSKDNLPRLPASVEKPDIESLQNQEMNRGSRGGSDHKNNVSDKAETIPLFSASAIPSNDGTVAGASETANESDIQISSKDIGESQLVKDGVESSSKSSSRSGVATDPPVIESSILNFPAKPDTPSSVNGLVSDAHKVDAQFSSSGSLLDFRCKTSENMVEDADENHSPVSIATVHNSDANCIQNHKVRNTPSASSSGTEVVQDLGNRDAFGKGSDGAVPEAVMKCVTVETVPRFFPETSSQNDLNQPVAMDDESESQASLKIVGDAKTASNLKIDSVGCDKGTSAGSDANNDARTDVKGCNCENASDSLKQGSSGNEFEREEEGHSSDSASRCTGAEVTAEVSFVHKNTSGIENGLSVASESHSEAEVPLPDNEVHCSSELEHGCEVNAGGVGGCPLSDSSGARVLEVSETRDRFDGAHKLDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSF8</accession>
    <name>A0A068TSF8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022319001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSF8"/>
    <dbReference type="FunCoup" id="A0A068TSF8">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSF8"/>
    <dbReference type="Gramene" id="CDO98278">
        <property type="protein sequence ID" value="CDO98278"/>
        <property type="gene ID" value="GSCOC_T00022319001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSF8"/>
    <dbReference type="OMA" id="LECYYLL"/>
    <dbReference type="OrthoDB" id="1906673at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSF8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38390">
        <property type="entry name" value="OS01G0103900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38390:SF2">
        <property type="entry name" value="OS01G0103900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="692" mass="77940" checksum="F06CC7E92D1CAF47" modified="2014-10-01" version="1">MGILCFVLDLRSLSPSLLRDLKQSLLQLANYYAIYTPSGGNSGLRTQSKPLLDRIGLCYIFTNRISCSVELKVAYSPTGNFSLRGFHHAVNNLPTDAFSPEFDISGSLSCTDMKISSILSDNVLYSWGGHARDITRKVFLISACIVQHLDDDTKKVLMDAADMCVSVEFIFVQHMANHLGDGVENINNFIKQIGDLENCSFRSCLSDAHVFSGMAKQWFQELKDDVEGSLHSRFIFKSNLLYNVNQLLCNLCRCFNPIVDGFIPCQTCWCHGIPLDKSNVDQSKGSYSCPETGQDLRELDLTENSVKIGENTILFMPSFECRQKLPQIVSPIDFHVIERTPLGSLNEGRFIFGASYVVAPSTFNEFDETDKSEQNNQLFQVICHLLNSLDQGLVCSSNCNVETMRETSFLCYYLLLPSDKGMMLLRRLVASEEILPVVDAHQFTYSTMAKEMESLVRSSLLKIEASTYSPQQHERGFHQKLNFLVKESLQFGAIPPKIREAPVDFSTLNDSEEAVEPTQAAAEVVEPTKMPPLSEEVQENEANSYIEEEWERLIVTELPQIHSPIQVSKPKLDHPLPSPSQSNRKIDEKTSKILERLEIPRQLKKKAVSPKTPGIGTSQTCMLTKKPLIPYGPSRADDQSWSSHSFLDASCMIFYRVISGRHLKNNEVHLLLRASKLKKEKEKEKEKLTTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTY3</accession>
    <name>A0A068TTY3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Non-lysosomal glucosylceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026613001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTY3"/>
    <dbReference type="FunCoup" id="A0A068TTY3">
        <property type="interactions" value="1792"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTY3"/>
    <dbReference type="Gramene" id="CDO99439">
        <property type="protein sequence ID" value="CDO99439"/>
        <property type="gene ID" value="GSCOC_T00026613001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTY3"/>
    <dbReference type="OMA" id="VYEEKLW"/>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000006">
        <property type="entry name" value="Non-lysosomal glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81614" checksum="56C3332E71DC4FF8" modified="2014-10-01" version="1">MKCFLSAPANLSLVSIVKNKEMTTKDNPPVTYAIAASETQNVSVSVLPCFGLTEGSCVTAKDMWGKMVEDGHFDRENFTKGPSMPSSPGETHCAAVSASTWVEPHGKCTVAFAVAWSSPKVKFMKGKSYNRRYTKYYGTSEKAAVDLVHDALTNYKLWEEEIERWQTPILKDDRLPEWYKFTLFNELYFLVSGGTVWIDSSLPTEDSWEVQNEAVPVKIKEVTVSKTQENHNQDMENNQTVVNTHVDMMYVNSQDDGVKSSKVSNERASNNSDEKDESTLFRRRFESRFTTSSSKLLENDTDDVGRFLYLEGVEYIMWNTYDVHFYASFALLELFPKIELSIQREFAKAVLCEDKRKVKFLAEGNCGIRKVKGAVPHDLGTHDPWHEMNAYNIHDTSRWKDLNPKFVLQVYRDFAATGDFSFAADVWPSVRAAMEYMEQFDRDHDGLVENDGFPDQTYDTWTVHGISAYCGGLWLAALQAAAAMAVQLGDRAFAERCKSKFVKAKAVFEEKLWNGSYFNYDSGSSSNSKSIQADQLAGQWYTASSGLPDLFDKVKIQSALQKVYDFNVMKNRGGRMGAVNGMYPNGKIDETCMQSREIWTGVTYSVAANMILAGMVEQGFTTAEGIFLAGWSEEGHGYAFQTPEGWSKDGHFRSLLYMRPLSIWGIQRAMSSTKTTLEAPVMNIMDRINIPYHNSTLSSRSESGVKKIAHKAKCFKNSVFHCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUF0</accession>
    <name>A0A068TUF0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00029572001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUF0"/>
    <dbReference type="FunCoup" id="A0A068TUF0">
        <property type="interactions" value="1599"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUF0"/>
    <dbReference type="Gramene" id="CDO99871">
        <property type="protein sequence ID" value="CDO99871"/>
        <property type="gene ID" value="GSCOC_T00029572001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUF0"/>
    <dbReference type="OMA" id="ANHFHEP"/>
    <dbReference type="OrthoDB" id="1939754at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUF0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33701:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33701">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO99871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="676" mass="73542" checksum="6F60E00DEE3A2E9E" modified="2014-10-01" version="1">MSSSVNEDHDQRNNGGLEDLTSMTIESLRARLLSERAMSRTSRQRADELAKRVVELEEQLKLVSLQRKKAEKATADVLAILESNGISDASEAFDSNSDQETVFSDSKVSNDSEKRKETLSNFQVRRRDMDSCSSSEIDSSPSTGRSLSWKSSKDSLHSLESKKYTETVRRRCSTFASNSSLPKRIGKSCRRIRRREARSVAEDSHDDDNTHDSQGKTVDTRSQACPNCADIKQPINNGATDLKETLVSGLSENRIADDYSSRSGQDDDFKSVLQHQAQLEEQYEEDTAQGEWEEKVRENSSCVVDSCDPGNRSDVTEEREEVKASGQSSPAGIRNSVDQQSDLEVAKTSFTSEMEPEVSKDLPISPHSETGYVQEQKTSSLVAHGSSSSEYAFPTSKGSLSQGVPGNVDSTPSTSSRTYLSDGSYGNPSVHVPFPSPNNGESSGSHKELALMPQKSSSDLESVLKALQQAKSSLNQKLHGMPLLEGGSSGNGVEPSFPGNKLTGGKVDVPVGCPGLFRLPTDFQLEGSAKVNYLSSNTALSLANSYPEPVPGWFANSSLAESRSSAFVGNHFDTTPYSGIGSGAHRPTPSYTLGASALEAGLSSSGRSNYLDPQTNGALLIPSRYAYPTYPFYQEVRPQVPGNERLSRYVPSVELGTPSPARFSFYDDHITPNMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV15</accession>
    <name>A0A068TV15_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IQ domain-containing protein IQM3-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00029594001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV15"/>
    <dbReference type="STRING" id="49390.A0A068TV15"/>
    <dbReference type="Gramene" id="CDO99887">
        <property type="protein sequence ID" value="CDO99887"/>
        <property type="gene ID" value="GSCOC_T00029594001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV15"/>
    <dbReference type="OMA" id="HYEYIIA"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV15"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF10">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO99887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48298" checksum="0C39AD13B868964C" modified="2014-10-01" version="1">MELNGQSLSTSESLKENDDSESRTAAVKLQKVYRSYRTRRKLADSAVVAEELWWHAIDYARLNHSTISFFNFSKPETAASRWNRISLIASKASIRMYKLKKLAFQHWIEAVDPRHRYGHNLNIYYDEWFGRDTGQPFFYWLDIGDGTKLDLDECPRSKLRQQCIKYLGPQERLHYEYVIAEGTFLHKQTGDLLNTTSGLKRAKWIFVMSASKRLYAAEKKKGYFHHSSFLAGGATLAAGRLVAEHGKVKSISTHSGHYRPTNENLGIFLAFLKDKGVNLEEVQLTLLSKNLYHNINELKPLPSIAALMVACLTSSYIRQVLPHAKEYEDDKLQIANCPEVTHKELLQRIESNREANSNQLGHQVSLKWSTGAGPRIGCIADYPHNLKERALKFIHLSSKDLQSSPSPQSTSQVLKLRNPCKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW52</accession>
    <name>A0A068TW52_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032119001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW52"/>
    <dbReference type="Gramene" id="CDP00237">
        <property type="protein sequence ID" value="CDP00237"/>
        <property type="gene ID" value="GSCOC_T00032119001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW52"/>
    <dbReference type="OMA" id="ADDERCK"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW52"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676:SF178">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="16851" checksum="8FE5AD25EAF121DF" modified="2014-10-01" version="1">MIKSLELITDWIIYPALLAFFCTIAIFSAFYITLGIKLAFDKLFAVVCERWHLGNNGATPPAPSPSVTANVQRKEVEEAVKVLEIIPAPATYKRNRNHSIVSCAICLEDLKDGELCQALPDCQHAFHSSCIKPWLIKRPNCPICRQSLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWB2</accession>
    <name>A0A068TWB2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029283001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWB2"/>
    <dbReference type="FunCoup" id="A0A068TWB2">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWB2"/>
    <dbReference type="Gramene" id="CDO99633">
        <property type="protein sequence ID" value="CDO99633"/>
        <property type="gene ID" value="GSCOC_T00029283001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWB2"/>
    <dbReference type="OMA" id="RWHFEYS"/>
    <dbReference type="OrthoDB" id="786450at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWB2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045286">
        <property type="entry name" value="FBS1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34049">
        <property type="entry name" value="F-BOX PROTEIN SKIP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34049:SF1">
        <property type="entry name" value="F-BOX PROTEIN SKIP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="20853" checksum="D14A1C631173EF61" modified="2014-10-01" version="1">MALGKKCGCNSQRGNGGFGMGLVRSTSFGRKRVALPSNDVMEIDCFDRTPTKKRCSYEASFFTSDKSTLEALPQDVLIRILCGVEHDDLKRLFFVSKSLREATLIAKQWHFAYSTPRKTLGFPNAIDLENLDEFNEIEQAPRQVRIPRARLSSKKLADISVALFTSAGEENWPRRELFVAMDAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWB8</accession>
    <name>A0A068TWB8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00029289001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWB8"/>
    <dbReference type="STRING" id="49390.A0A068TWB8"/>
    <dbReference type="Gramene" id="CDO99638">
        <property type="protein sequence ID" value="CDO99638"/>
        <property type="gene ID" value="GSCOC_T00029289001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWB8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWB8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000037">
        <property type="entry name" value="Heat stress transcription factor B-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF294">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN HSF30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="12">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="12">
        <location>
            <begin position="385"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO99638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="616" mass="70214" checksum="EE6780706E903DC6" modified="2014-10-01" version="1">MEATNQETSEVTNSIRYELKNGENEGERVNPTIPIGTDVSESSSNAIVTATAISTIPLAKEGYANGASSSSSRVRLPPPFLLKVYDIVKNPETDSIISWSSSGTSFIVWDPHRFAAEVLGKYFRHNNFASFICQLNTYLQIKARKLEYQMNLPTSINIDGFRKINWDRLEFQNAWFQKGKKSWLKKIKRRIQGTQSAHLCKPLEIEGQLSLSVEQKKFESLMQEHDALKVEMMKLKDMEENLVKEIEILEKQAQCITSNRQNMLKYTIHEVLIRKRKLQSNDAANELGSGGRQSIESSVELLDEGGTSHGSRKNSPRAQSGTGKTFSNVDLSTTVQEEEDCTVSMGKFSDFYNAVYSSLEKQLMDDINCKNVPEEEKANLQQNVVIPLEDLIEGPADWNEFAKGIGTSLIVLDHLKFAAEVLPKYFKHSNFSSFIYQLNNYGFRKIGLRQYEYENNWFQRGQEHLLMHIRRRNDEDPTIMKKRGPKKQHVTAARPSMEAELKIFEDHINALKEDITRSKYHMGKLESSIATFKKNVKIMEAKSKVLIKVLARIFNPALVEKIIQHVEEEPELEILQTMKRRRVILPQSSNTTTKSTDNGACGKDQDDQEANTSIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY25</accession>
    <name>A0A068TY25_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inositol-tetrakisphosphate 1-kinase</fullName>
            <ecNumber evidence="13">2.7.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00034459001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13253"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.159"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13254"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20940"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.159"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57539"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:12453"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:12454"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:189099"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70288"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13 15">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ITPK1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.134" evidence="13"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY25"/>
    <dbReference type="FunCoup" id="A0A068TY25">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TY25"/>
    <dbReference type="Gramene" id="CDP00982">
        <property type="protein sequence ID" value="CDP00982"/>
        <property type="gene ID" value="GSCOC_T00034459001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY25"/>
    <dbReference type="OMA" id="QHLYNRQ"/>
    <dbReference type="OrthoDB" id="25308at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY25"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052835">
        <property type="term" value="F:inositol-3,4,6-trisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.220:FF:000002">
        <property type="entry name" value="Inositol-tetrakisphosphate 1-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11370:FF:000002">
        <property type="entry name" value="Inositol-tetrakisphosphate 1-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041429">
        <property type="entry name" value="ITPK1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF39">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17927">
        <property type="entry name" value="Ins134_P3_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038186">
        <property type="entry name" value="ITPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol-tetrakisphosphate 1-kinase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="16">
        <location>
            <begin position="104"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4,6-tetrakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR038186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP00982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="302" mass="33931" checksum="0ACE7E7F378602EE" modified="2014-10-01" version="1">MKIVVVGYALTSKKIKSFLQPKLEGIARNKGILFVAIDQTKPLSDQGPFDIVLHKLSGKEWQHVLEDYRQTHPDVTVLDPPDAIQHVYNRQSMLEDVADLNLSDAYGKVGVPRQLVIKKDPSSIPDAVNSAGLRLPLVAKPLVAKSHELSLAYDQYSLKKLEPPLVLQEFINHGGVLFKVYIVGEAIKVVRRFSLPDVSKPELLKNAGVFRFPRVSCAAATADEADLDPSVAELPPRPLLEKLARELRRRLGLRLFNLDIIREHGSADKYYVIDINYFPGYGKMPEYEHIFTDFLLSLARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY28</accession>
    <name>A0A068TY28_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032935001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY28"/>
    <dbReference type="STRING" id="49390.A0A068TY28"/>
    <dbReference type="Gramene" id="CDP00834">
        <property type="protein sequence ID" value="CDP00834"/>
        <property type="gene ID" value="GSCOC_T00032935001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY28"/>
    <dbReference type="OMA" id="YDYVRMG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY28"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF77">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="305" mass="34445" checksum="2111BCC8201B8ECB" modified="2014-10-01" version="1">MALSADISGVKLVFLGNVVGEYELEDLLHSDFSMLGKGTLGMSYKARLELEDEYTLAVKRVNVGRLSEMEFKEKIEELGKMDHENLLPIRAYCCIQEKRILVYDYIHMGSLAYLLHGNGDANKTPLNWDIRCRIAYGVTRGIAYIHTQGSNICHGNLRSSNVFFNSPFDVRVSEFGLAQLVPVESKLILNEGYRAPEVTSNHEVSQKSDVYSFGVLLLELLTGKAPLRAVRELEGIDLVKWVRQMFQEKPILDVFDDDLVLNYGSDEEQMVQLLQLAVCCTFQNPSKRPSMAAAANRIEEICRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ11</accession>
    <name>A0A068TZ11_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DOG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00032574001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ11"/>
    <dbReference type="FunCoup" id="A0A068TZ11">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZ11"/>
    <dbReference type="Gramene" id="CDP00588">
        <property type="protein sequence ID" value="CDP00588"/>
        <property type="gene ID" value="GSCOC_T00032574001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ11"/>
    <dbReference type="OMA" id="GDHGHSI"/>
    <dbReference type="OrthoDB" id="2015618at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ11"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000019">
        <property type="entry name" value="BZIP family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR PERIANTHIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DOG1" evidence="11">
        <location>
            <begin position="250"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51742" checksum="884CE498E22C1252" modified="2014-10-01" version="1">MQSFKSATAAAPAVVTLTNSDMYCRSSIYLRGHEGGGGGRNWTNYVDLGELEQSSFHQEHAVDLSTSSIYSDMKPSNVVAVSNSSLQFGGLNTNMGSGAMGSSGAVADTGQFLMQKGTMLSVGAGGTLGSGNFENWGESGMADHSQQTDTSTDVDTDEKSQFHGVRRRTLVGMDSMEQSGERNGDQKTLRRLAQNREAARKSRLRKKAYVQQLENSRLRLTQLEQELKQARQQGVLKASGYTGDQSMSGALAFDMDYARWLDEHQRMINDLRTAVNSQLGDNELRLLVDGVMSHYDEIFRLKDIGTKSDVFHMLSGMWKTPAERCFMWLGGFRSSEILKILGDHLEPLTDQQLIGICNLQQSSQQAEDALSQGMEALQQSLVETLSSNSLGPSGSSNVADYMGQMATAMGKLAMLENFLRQADLLRQQTLQQMHRILTTRQAARALLVINEYMSRLRALSSLWLARPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ73</accession>
    <name>A0A068TZ73_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036658001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ73"/>
    <dbReference type="FunCoup" id="A0A068TZ73">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZ73"/>
    <dbReference type="Gramene" id="CDP01566">
        <property type="protein sequence ID" value="CDP01566"/>
        <property type="gene ID" value="GSCOC_T00036658001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ73"/>
    <dbReference type="OMA" id="WGFKERE"/>
    <dbReference type="OrthoDB" id="686813at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ73"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34464">
        <property type="entry name" value="OS09G0376300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34464:SF3">
        <property type="entry name" value="OS09G0376300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="177" mass="20505" checksum="4AB25DEC0274DAA0" modified="2014-10-01" version="1">MAVSWTRFSWWWWSGKEKEPVPNGSSSMNTLPDWGFGLREPDNLKFRSVMAAKMAPSSRKVKRKWKSREERRRIDKEYDVVLVPSDGVCLSGSESDDSDWSIGWLEPHAPDFQSEDEADDSFAVLVPCYRHAYTELEREPRGSNQFLSAIKNLPNEYSDVSDGKKYVEQWLSSLQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZE8</accession>
    <name>A0A068TZE8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032744001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZE8"/>
    <dbReference type="FunCoup" id="A0A068TZE8">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZE8"/>
    <dbReference type="Gramene" id="CDP00698">
        <property type="protein sequence ID" value="CDP00698"/>
        <property type="gene ID" value="GSCOC_T00032744001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZE8"/>
    <dbReference type="OMA" id="ARFHTHQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZE8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23123">
        <property type="entry name" value="RING-H2_RHA2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="173" mass="18726" checksum="B330E96C150C84B7" modified="2014-10-01" version="1">MGLQNQLADISTESFPILMVALVANCVGYIRSILIGAFQAFGLSLAMFDVSNLYHVDDASCDAVGSGLTGIIMLAEQLKLNRAFSYRLAGDGAAGCGSGSGSDCVVCLNRLGEGDHVRKLACRHVFHKECFDGWLDHMNFNCPLCRMPLVADECVAATKRRVTGDVLEWFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0N0</accession>
    <name>A0A068U0N0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00036817001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0N0"/>
    <dbReference type="STRING" id="49390.A0A068U0N0"/>
    <dbReference type="Gramene" id="CDP01684">
        <property type="protein sequence ID" value="CDP01684"/>
        <property type="gene ID" value="GSCOC_T00036817001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0N0"/>
    <dbReference type="OMA" id="CMNIKAN"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0N0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000002">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12542" checksum="BB00C794A5486326" modified="2014-10-01" version="1">MVISKTASQSDVSVHSTFASRYVRASLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECDKLIMAAINKNYVDMDEYPVTTELQASLLLLLLPFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0R0</accession>
    <name>A0A068U0R0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase II protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034722001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0R0"/>
    <dbReference type="FunCoup" id="A0A068U0R0">
        <property type="interactions" value="1310"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0R0"/>
    <dbReference type="Gramene" id="CDP01173">
        <property type="protein sequence ID" value="CDP01173"/>
        <property type="gene ID" value="GSCOC_T00034722001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0R0"/>
    <dbReference type="OMA" id="TCAICEN"/>
    <dbReference type="OrthoDB" id="2019752at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0R0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53704" checksum="16D7C101A6B5539D" modified="2014-10-01" version="1">MTRRTNTSCAICDSSNLASICPVCVNYRLNEYSTNLKSLKSKKDALYSKLGEALLAKRKADDQKSWLLLQKEKLIKMKEKLHLRQQEVLQGKSMIEAMSHDLDAKYELLESAMSVLQKNQVEQLEKFYPNLICTQSLGHMAITSELLHRQSVIVKQICKLFPLRRLNVDGDRKDGFTGQYDTICNARLPRGLDPHSVPRDELAASLGYMVQLLNLVVHHVCAPALHNSGFAGSCSRIWQRDSYWDARPSSRSSEYPLFIPRQNFCSTSGETSWSDRSSSNFGVASMESDRKPHLDSSRSSSLNYSSASPHSIETHNDLQKGISLLKKSVACATAYCYNSLCLEVPAEASTFEAFSRLLSILSSSKQVRSFVSSKMASSRSSKQAQQLNKSVWKVDSAISSSTLVESAHAFPMKRNVFDSHVPSSASSFLFPTEFSDIGKNENFIEGWDLVEHPTYPPPPSQTEDVEHWTRAMFIDATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0X0</accession>
    <name>A0A068U0X0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00036983001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0X0"/>
    <dbReference type="FunCoup" id="A0A068U0X0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0X0"/>
    <dbReference type="Gramene" id="CDP01814">
        <property type="protein sequence ID" value="CDP01814"/>
        <property type="gene ID" value="GSCOC_T00036983001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0X0"/>
    <dbReference type="OMA" id="MNTSFTM"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0X0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF8">
        <property type="entry name" value="PROTEIN DETOXIFICATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP01814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="563" mass="59834" checksum="B5874C8D2551342A" modified="2014-10-01" version="1">MAAIKLNGGVAPGISGTKCERRVIKKAFRVGILSGISSNHHFLGVSQRKGFRFNNAVKNCAYVSDQGALEYEIGTSGAQETFTSTREKLINGSNEGAIALTGISSEQQQTPSVQTELIMLSVPAIAGQAIEPLAQLMETAYIGKLGALDLASAGISICIFNIISKVFNIPLLSVATSFVAEDISRQDNEESSSDERMTLPSVSTALVLSMGIGLFEAAAMFFGSGVFLSMMGISMASPMRIPAEHFLKLRALGAPAVVLSLAIQGILRGFKDTRTPVLCLGLGNFAAVFFFPVAMYVFQLGVTGAAISTVASQYIVTVLMLWHLNKRTALLLPSLKSLHFGDYLKSGGFLLGRTLAAVLTVTLSTSMAARQGALSMAAHQICLQVWLSASLLVDAQAAAGQALIASSLAKRDYGRVKEITYMAIKTGLFTGISIAVILGLSFPSIAKLFTNDVQVLDIVKSGLLFVSASQPLNALAYIFDGLHYGVSDFPFAACSMMVVGAISSAFLLYAPSIVGLSGVWSGLTIFMGLRTVAGYMRLLAKDGPWWFLQENKKTEVGDMKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0Z8</accession>
    <name>A0A068U0Z8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039503001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0Z8"/>
    <dbReference type="FunCoup" id="A0A068U0Z8">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0Z8"/>
    <dbReference type="Gramene" id="CDP02185">
        <property type="protein sequence ID" value="CDP02185"/>
        <property type="gene ID" value="GSCOC_T00039503001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0Z8"/>
    <dbReference type="OMA" id="GKQIQNW"/>
    <dbReference type="OrthoDB" id="426361at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0Z8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001236">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g28660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000470">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g66520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58057" checksum="CD4E3D83D6BF0B64" modified="2014-10-01" version="1">MNHLINAHRHCRTIYTTSTQRSIRAWKWCMCIIGRCTSMQELKAIHSIFITHGLHRNNYAVSKLLDFCALADCGDLSYASLLFTQLPSPSCYLYNTLIKAYSTSPQPHLALQCFNLMLRSLLPPDGYTFPFVLIACSNGCFTSEGEQLHCWVTKNGLASANPHVQTALIRFYAASKSLVAARQLFGEITDSDVVQCNVLISGYVKCGMASEALDVFRGMLLRGVEPDEFCLTTGLTACAKLGALEQGKWIHEYIRRRNLMGSDTFIGTQLVDMYAKCGCIDMAVEVFESIPKRNKFSWASMIGGFAAHGYARKAIDCLERMQAEDGIKPDGIVILGVLAACTHAGLPREGQFLLNNMETLYGVPPEHEHYSCIVDLLCRAGQLCEALELIRSMPMKALASVWGAFLSGCRMNNNVILAELAVKELLQLEGGNEAEESSAYVQLSNIYLAAQKCEDARRFRRMIGDRGLKKAPGCSAIEIDGEVNEFVSGDVSHHCLANICAILDLVSTDLSIGRSWQMEDLAYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U405</accession>
    <name>A0A068U405_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UTP23 sensor motif region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00041317001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U405"/>
    <dbReference type="FunCoup" id="A0A068U405">
        <property type="interactions" value="2683"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U405"/>
    <dbReference type="Gramene" id="CDP02904">
        <property type="protein sequence ID" value="CDP02904"/>
        <property type="gene ID" value="GSCOC_T00041317001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U405"/>
    <dbReference type="OMA" id="HTSGLQM"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U405"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08553">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP02904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="283" mass="32024" checksum="C7DE25F421D33126" modified="2014-10-01" version="1">MRVKKQKRHRKAVRFYTACCGFREPFKVLCDGTFVHHLLLNKITPADIALANALGGPVKIFTTRCVLGELRSLGDSYAESLNAARNLLTARCDHEKRKSAVSCITDVIGENNSDHFFVATQDAELRKKFQKVPGVPLIYGLRNALFLEQPSAFQQQFVRSAEEDRSHMTDLEYKLLNVKKKNVAFEEAKDSADANEDKNDGTLTVQAIQTNFRKKRDLKDTVQFKRKRAKGPNPLSCKKKKPRDNTNNAASVKENGNGDTTVRSRNRKRKRSRKSKNVSKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4L4</accession>
    <name>A0A068U4L4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Trichome birefringence-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00039973001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4L4"/>
    <dbReference type="STRING" id="49390.A0A068U4L4"/>
    <dbReference type="Gramene" id="CDP02553">
        <property type="protein sequence ID" value="CDP02553"/>
        <property type="gene ID" value="GSCOC_T00039973001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4L4"/>
    <dbReference type="OMA" id="YREYNFN"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4L4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF247">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="152"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="10">
        <location>
            <begin position="574"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="9">
        <location>
            <begin position="628"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP02553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="107140" checksum="B25B61D1946C3401" modified="2014-10-01" version="1">MKFQALDLPSRKKRHETRKQAPKIASLIVLAILLSVISVYSPPLQFRKFSEASSPLDSLKESINTSLQSLPCRPEDDGSQPCSNTEEGEPEARPEVVEKCDLFAGEWVPNPDAPYYTNTTCYVIQEHQNCLKYGRPDLDFLKWRWKPDGCELPIFDPHQFLELVRGKSIAFVGDSVSRNHMQSLFCLLSKVLYPEEISSTTDESRQWKYKEYNFKISILWAPYLVRSAEITSPNDKARSFGLYLDEFDENWTTKIEGYDYVVISGGHWFFRPAMLYENGRIVGCLYCPQENVTHVTPLFSYQRAFRTAFRAINSLGNFKGVTFLRTFSPQHFENGTWDSGGNCVRKRPYKRNEILLADNNLEMYKIQLQELKIAQKEGSKRGLKFRLFDATKPMLLRPDGHPSIYGHWPSQTVEMPNDCVHWCLPGPIDTWNDFFLELLKREESEKSFNDYVHKIGKIRTTRDLGSRIKNEERHPRESIRRPEKDDEPEAANSPETEPSEPPSSIKSDLIVARTTLDRNNSERRSAPSPSPSQGDENEGRTRIPIQRSPEQTKRVSPVPNPAGGIDHSKLGDKESCDLFTGEWVPNPEAPYYTNSTCYGIYDHQNCMKYGRPDTDFLKWRWKPDGCELPIFDPHQFLEVVRGKSIAFVGDSLARNHMLSLMCLLSRVLYPLDVSTANDENRRWVYREYNFNVSMFWAPYLVRSERTDPNDITRPFNLYLDEFDDGWTTKVQAYDYIIISAGQWFFRPTNFYENRTLIGCLACKQDSVTQFTMNFSYERAFRTAFRAIISLANFKGVTILRTIAPSHFEGGVWDQGGDCVRTRPFKRNETVLADYISELHKIQLKELRIAQEEGSKWGLRFRLFDVTQAMSLRPDGHPSKYGHWPTEKVTNDCVHWCLPGPIDAWNDFLQELIKREETKKSSYRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4T7</accession>
    <name>A0A068U4T7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00041853001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:21760"/>
            <dbReference type="ChEBI" id="CHEBI:57315"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="EC" id="5.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4T7"/>
    <dbReference type="FunCoup" id="A0A068U4T7">
        <property type="interactions" value="1973"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4T7"/>
    <dbReference type="Gramene" id="CDP03312">
        <property type="protein sequence ID" value="CDP03312"/>
        <property type="gene ID" value="GSCOC_T00041853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4T7"/>
    <dbReference type="OMA" id="YNGAAMG"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4T7"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008692">
        <property type="term" value="F:3-hydroxybutyryl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000004">
        <property type="entry name" value="Peroxisomal fatty acid beta-oxidation multifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000025">
        <property type="entry name" value="Peroxisomal fatty acid beta-oxidation multifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309:SF49">
        <property type="entry name" value="PEROXISOMAL BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="21">
        <location>
            <begin position="311"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="20">
        <location>
            <begin position="491"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="20">
        <location>
            <begin position="623"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="724" mass="78178" checksum="71458E1B6DAA0E46" modified="2014-10-01" version="1">MAKPGVTMEVGNDGVAVISIYNPPVNSLAIPILAGIKEMFDEAVRRNDVKALVVFGKGGKFSGGFDINVFGNVHKTGDNSVLPDVSIDLLVNTIGDAKKPAVAAVEGLALGGGLELAMACHARIAAPRAQLGLPELTLGVIPGFGGTQLLPRLVGLSKAIEIMLLSKSIMSEEGKKSGLIDEIVSSGELLNVSRCWALDIAERRKPWLRTLHRTDKLGSLAEARNILKAARQQAKQVARNMPQHQACLDAIEEGVVHGAYSGVLREAKVFKEIVLSDTSKGLVHNFFAQRATSKVPNVTDVGLKPRPVKRVAVIGGGLMGSGIATALILSNIYVVLKEINSEYLLKGVKAIEANVWGLVSRKKLTDDKAQKALSLLKGVLDYSEFKDVDMVIEAVVENISLKQKIFGELEKICPPHCILATNTSTIDLNIIGEGTKSQDRIVGAHFFSPAHVMPLLEIVRTEKTSAQVILDLMTVGKIIKKVPVVVGNCTGFAVNRAFFPYNQGAHFLLHLGVDPFRIDQLISNFGLPMGPFQLQDVAGYGVAVAVKEIFASAFAGRTFESSLVDLLIKNGRNGKSNRKGYYIYQKGSKAKPDPSVLPIIDESRKLANLMPGGKPISVTDQEVVEMILFPVVNESCRVLDEGIVIRASDLDVASVLGMSFPTYRGGIVFWADTIGADYIYKKLKKWSEAYGNFYKPSRFLEERALRGIPLSAPTSTSSASKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7B2</accession>
    <name>A0A068U7B2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TIC110, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016608001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7B2"/>
    <dbReference type="FunCoup" id="A0A068U7B2">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7B2"/>
    <dbReference type="Gramene" id="CDP04069">
        <property type="protein sequence ID" value="CDP04069"/>
        <property type="gene ID" value="GSCOC_T00016608001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7B2"/>
    <dbReference type="OMA" id="PTEYAQK"/>
    <dbReference type="OrthoDB" id="191196at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7B2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061927">
        <property type="term" value="C:TOC-TIC supercomplex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045037">
        <property type="term" value="P:protein import into chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031610">
        <property type="entry name" value="TIC110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935:SF3">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16940">
        <property type="entry name" value="Tic110"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112911" checksum="5A41B2602F18393D" modified="2014-10-01" version="1">MNTSIFLTASPSVAQPKVLFSPFLPPNPLRLSTTLAYHQSHRRRRYRISTIRSASIPTSLSASSSSDQPIKAIKPDVFGGKKELTGFQALADAMSPTVRIASSALIFAGAIAAGYGLGSKFGGSRNVAMGGAVALGTAGAGVAYALNSCVPEVAAVNLHNYVADFDDPAALTKEDIEAIANRYGISKQNEAFNAELCDIYCRYVSSILPPGNEDLKGDEVETIIKFKNALGIDDPDAAAMHMEIGRRIFRQRLETGDRDADLEQRRAFQKLIYVSTLVFGEASSFLLPWKRVFKVTDAQVELAVRDNAQRLYGFKVKSIGQDVNVDQLVGLREAQLAYRLSDELAEDMFKELTRKLVEENISTALNILKSRTRASEATRIVEELNKVLKFNNLLISLKNHPEANRFARGVGPVSLLGGEYDSDRKIDDLKLLYRAYVWDSLSSGRMAEDKLTALNQLRNIFGLGMREAESIKLEVTSKVYRRQLAQAVSSGDLAAADSKAAYLQNLCEELQFDAEKAVEIHEEIYRQKLQQAVADGALSDEDVKVLEKLQIMFCIPRETVEAAHADICGSLFEKVVKEAIAAGVDGYDAEIKKSVRKAAFGLRLTREVALNIASKAVRKIFISYIQRARAAGSRTESAKELKKMIAFNSLVVTELVADIKGESSDTPPAEAPVEKEEKVVDEGEDEEWESLQSLRKVRPGKESLAKKGQTEINLKDDLPERDRTDLYKTYLLYCITGEVTNIPLGTQFTTKKDDSEYALLNQLGGILGLTSKEIVEVHRSLAEQAFRQKAEVILADGQLTKARIEQLNELQKDVGLPPQHAQKIIKGITTTKMAAALETAVAQGRLSIKEIRELREAGVELDTMISESLRENLFKKTVDSIFSSGTGEFDEEEVYEKIPKDLNINVEKAKRVVRDLARSRLSNSLIQAVALLRQRNHIGVASSLNDLLACDKAVPSTSLTWEVPEELADLYVIYLKNDPAPEKLSRLQYLLNISDSTAEALQAMKDRALPNGNATAGEEEFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7U2</accession>
    <name>A0A068U7U2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Signal recognition particle 19 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00018644001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7U2"/>
    <dbReference type="FunCoup" id="A0A068U7U2">
        <property type="interactions" value="2927"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7U2"/>
    <dbReference type="Gramene" id="CDP04630">
        <property type="protein sequence ID" value="CDP04630"/>
        <property type="gene ID" value="GSCOC_T00018644001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7U2"/>
    <dbReference type="OMA" id="ERTKCYP"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7U2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 19kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15173" checksum="42F1AF9989274A0F" modified="2014-10-01" version="1">MDGNIQAIKKWIVLYPIYINSKKTIAEGRRISVSKACENPTCVEIHDCCIHLKLPCAIEVDKAYPRDFMQRGRVRVMLKREDGSLFNPAISSRKQLMLRVAELVPKHSNRTKKQEPATSSAAGPSKPAKGGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7Y6</accession>
    <name>A0A068U7Y6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00018652001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7Y6"/>
    <dbReference type="Gramene" id="CDP04636">
        <property type="protein sequence ID" value="CDP04636"/>
        <property type="gene ID" value="GSCOC_T00018652001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7Y6"/>
    <dbReference type="OMA" id="KMEHASK"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7Y6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP04636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54134" checksum="33195BF655886852" modified="2014-10-01" version="1">MARMRPLPSVIDFTQLLDRIVKMEKHYSSVVSLFRDMCVQGIPVDEATLNIMINCCCVVGRVDLAFSTLSGFFKRGFVPNVVTFSTLLKGLFRDHKVPEAQELFKKIIKEKLCKPNETMLGIVIDGLCKAGNTQTAIDLLRAMEKRGRPCKPTAIIYNTVIDSLCKDKMVDEGLALLQDIPPNVVTYSCLIHGLCNLSRWEDVDKLFYEMKVYKIVPDVISFNIVVDALCKEGHIEDAEEVVRIMIQQGQNPNLVTYTSLMDGYCLQRRIDDTRRVFDTMMQASGMKPDFHTYCVVLDGLCKTGHVDEALELFHATEADGTDLHIEMYNIMLDGLCKCRRVDSARDLFKNLSLKRLDPDVITYNTMIAGLLSEGLLIEGKELVEKMEEKGCLANSVTYNVILQGLLKGGHYDDGIVYHEEMVHRGFLLDASTFSILLDLSAENQNNPSVLMLMLKIDPDSKNKIILCSYSLILKQIHIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9E2</accession>
    <name>A0A068U9E2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00020067001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9E2"/>
    <dbReference type="FunCoup" id="A0A068U9E2">
        <property type="interactions" value="2963"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9E2"/>
    <dbReference type="Gramene" id="CDP05126">
        <property type="protein sequence ID" value="CDP05126"/>
        <property type="gene ID" value="GSCOC_T00020067001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9E2"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9E2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000006">
        <property type="entry name" value="Trafficking particle complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="18936" checksum="BB325C25670BB57F" modified="2014-10-01" version="1">MQFFGGSEISPSPPVPTAAGNNAHMLYVFNRNGVCLLYREWNRPLKTLSPQQDHKLMFGLLFSLKSLTAKMDPTSADKGNLGVPQLPGQGCSFHSFRTNTYKLSFMESPSGIKIILVTHPRTGDLRESLKYIYNLYVEYVVKNPLYSPGNPIRSDLFNSTLDQYVRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAD5</accession>
    <name>A0A068UAD5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF819 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020103001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAD5"/>
    <dbReference type="Gramene" id="CDP05154">
        <property type="protein sequence ID" value="CDP05154"/>
        <property type="gene ID" value="GSCOC_T00020103001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAD5"/>
    <dbReference type="OMA" id="ASNIPCE"/>
    <dbReference type="OrthoDB" id="45797at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008537">
        <property type="entry name" value="DUF819"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289:SF5">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN (DUF819)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF819)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05684">
        <property type="entry name" value="DUF819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="26403" checksum="319FCFAD18E78794" modified="2014-10-01" version="1">MQSKEAPLCLHLGSLSINYVAISEALGTSSSIVAAGVAADNVICAVYFIVLFGLASKIPSETSFFSNNATTDLPSDSASKLPVLQMGTSLAVSFAICKASTSLTRFFGIQNCDLPVITTIVVILATSFPGYFRPIAPTADAIAVVLMQVFFAVVGAGGSIWNVINTAPSIFLFAFVQVTVHLILILGLGKLFCVDLKLLLLASNANIGGPTTACGMAKAKAWDSLVVPGILAGIFGVSIATFLGIGFGILVLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB47</accession>
    <name>A0A068UB47_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020580001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB47"/>
    <dbReference type="STRING" id="49390.A0A068UB47"/>
    <dbReference type="Gramene" id="CDP05502">
        <property type="protein sequence ID" value="CDP05502"/>
        <property type="gene ID" value="GSCOC_T00020580001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB47"/>
    <dbReference type="OMA" id="FLCIYSE"/>
    <dbReference type="OrthoDB" id="1930691at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB47"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF15">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="229" mass="25898" checksum="E114F93EBBEBDFD7" modified="2014-10-01" version="1">MASSRINEDRSNRSAAHRAVLEGKKQSVETFRSFWREEGVRPLDKRGATVLHFLAIYGNVDAFRLLLQDGLVTIENLKAKNVNGHTALHEAARFGHKDVAEIMLRTEKDLVSERNKLGETPLFVAAACGKKDVFSLLEKYIGDCMMRRNDGCTILHAAVIGGYYSKLLYQVWQLAYWSRILILLANVMKKEKLLYIFWLQNQSPSGVFLPTRSTILGGSPSFLCIYSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB86</accession>
    <name>A0A068UB86_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00020943001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739102">
        <property type="protein sequence ID" value="CDP05711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB86"/>
    <dbReference type="FunCoup" id="A0A068UB86">
        <property type="interactions" value="2534"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB86"/>
    <dbReference type="Gramene" id="CDP05711">
        <property type="protein sequence ID" value="CDP05711"/>
        <property type="gene ID" value="GSCOC_T00020943001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB86"/>
    <dbReference type="OMA" id="KQKLWGW"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB86"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000050">
        <property type="entry name" value="protein disulfide-isomerase A6 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654647" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="172"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP05711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="438" mass="47202" checksum="09AFE46528F1D7F3" modified="2014-10-01" version="1">MRGLFFGFSFILICIELFVGANALYGPSSPVVQLNPSNFKSKPSAFSFSPVVQLNPSNFKSKVLNSNGVVLVEFFAPWCGHCKALTPTWEKAASVLKGVATVAALDADAHQSLAQEYGIKGFPTIKVFAPGKSPVDYQGARDVKPIAEFALQQIKALLKDRLNGKATGGSSEKSEKSEPSVSVELNSHNFDDLVLKSKDLWIVEFFAPWCGHCKRLAPEWKKAANNLKGKVKLGHVDCDAEKSLMSRFNVQGFPTILVFGADKDSPSPYEGARTASAIESFALEQLETNVLPPEVTELTGPDVMEEKCGSAAICFVAFLPDILDSKAEGRNNFVWAAAGKQSDLEKQVGVGGYGYPALVALNVKKGAYAPLKSAFGRDQIIEFVKEAGLGGKGNLPLGVTPSIAKIEPWDGKDGEIIEEDEFSLDELMGDDTANKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBA0</accession>
    <name>A0A068UBA0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00020546001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBA0"/>
    <dbReference type="STRING" id="49390.A0A068UBA0"/>
    <dbReference type="Gramene" id="CDP05479">
        <property type="protein sequence ID" value="CDP05479"/>
        <property type="gene ID" value="GSCOC_T00020546001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBA0"/>
    <dbReference type="OMA" id="QMEISWF"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBA0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010328">
        <property type="term" value="F:auxin influx transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF18">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="50"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="301"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="638"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="959"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP05479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1204" mass="129903" checksum="E82AF7B2C6D585F3" modified="2014-10-01" version="1">MENNDQNTSVKASGNQELPHKGRKEEEVADKVPYYKLFSFADRADYVLVLVGTVAAVGSGICLPLMQVILGEMINSFGETLDRKQVVHEVSKVSSKYVYLALGSGVASFLQVACWNVTGERQAARIRSLYLRSLLMQDIAFFDKEISTGEIIERISVDTITIQDAIGEKVGKFIQVSASVSGGFIIAFIKGWLLSLVLLSSIPPLILASSAMTIQLAKRASQGQAAYSVAATVVEQTLSSIRTIAAFTREKKAIVEYGNSLNTAYKSGVQEGLAAGLGFGLFTFFSYCTYALAIWFGAKMISEKDYSGGDVLNVTLAVLSGSFSVGHASPCLSAFASGQAAGFKIFQIMKRKPGEVLIDGVNIKEFQLKWIRSKIGLVSQEPVLFASSIGDNIAYGKDSASLEEIKAAAEHANAAKFIDKLPQGLDTMVGLHGIQMSGGQKQRIAIARAILKDPRILLLDEATSALDAQSERIVQQALDGVMVNRTTVVVAHRLSTVKNADKIAVTDQGKIVEKGSHAELLQDPEGAYSQLIRLQQLSKQSYDHVMDNHDGSEIEVDSGRHSSQRISSLKSISQCSSAVGNSSRHSFSISISPPAVVSMQETALGKSQEPVLMPSNMDQQVPLYRLANLNKPEIPQLLLGSIAAVVAGAILPIFGVILSRAIKTFYEPPRELHNNSRFWALMLVVLGVSALLATPLKTYYFAVAGCKLIRRIRLKCFEKIVHMDISWFDRQENSSGRISSRLSIDATSVRSLVGESLSLLVQNSATVFAGLLFSFAASWRLSLIVIFTLPLIGLNGYMHLKSLSGFGADAKKLYEEATQVASDAVGSIRTVASFSAEDKVIFLYEKKCKGPVTIGIKQGLYGAVGYGLSMFFFYSVYAIIFYTGARLIKAGETTFSEVFQVFYGLSMAAVSISQSGMLSPDFSKARSGAASIFALLDLNSPIDSSKTTGITMDNVKGDIVFQHVSFKYPSRPEVQIFKDLCLAIESCQTLALVGESGSGKSTVISLLQRFYDPDSGKITLDGVELQSLNLKWLRQQMGLVSQEPVLFNGTIRANIAHGKEGSATEAEIISAAEKANAHNFISSLQQGYDTIVGERGIQLSGGQKQRVAIGRAIIKSPKILLLDEATSALDAESEKVVQDALVQAMVGKTAIVVAHRLSTIKGADLIAVVKNGVIQEQGSHESLISMKDGIYASLVKQYSSAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBH9</accession>
    <name>A0A068UBH9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00020663001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBH9"/>
    <dbReference type="Gramene" id="CDP05549">
        <property type="protein sequence ID" value="CDP05549"/>
        <property type="gene ID" value="GSCOC_T00020663001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBH9"/>
    <dbReference type="OMA" id="ICHNSTI"/>
    <dbReference type="OrthoDB" id="1600340at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBH9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP05549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="897" mass="99549" checksum="A43CBEBA15A016F3" modified="2014-10-01" version="1">MKTKKLLNPMGHLNFLDTTSSLPFLFLFITILVASQIPLGCTGQAHSSNFTCIESERQALLRLRDSLTDESNRLSSWIGEDCCSWDGISCHKITGHVVTLDLRNLEQPELYEVLDPSYHCKSCLAGDQLSPSLVNLTNLRYLDLSLNNFSGIQIPTFLGLLKDLRYLNLSDAGFVGEVPRHLGNLSHLRYLDIGFASSNYIPIANNLTSNDVGWVARLSSLEYLFLRGVNLSNARDGFLAVSMLPSLKTLDLASCKLVVPHLLHVNFTSLSSLELGSNQFLNPTLPPWLRNLTGLQDLGLSYNNLDDKVHDTFRQMTSLVNLDLGGNHFDTSTLRSICNISSLTSLDMSDNELQGSIPSEIGQFPQLTVLKLSNNRLNDTIPSSLWQLTKLQALYIGANALTGELSEHHFAKLKELKRLDISDNLFSLHVSSSWVPPFQLQYIGMGSVKIGPRFPNWLRTQKEIEKLNMANAGISDAIPSWFGVLSNDFRGIILPGNKLEGSLNSFISVADVDKKVVQMLYLVLNHNHFTGSIPKDLCKLKTLEYLDLSNNHLSGRIPLCLGNLRNLRILHLGSNSLYGQIPGSLGNLGELIILQLSKNRFDGKLPPSMQNLKRLQSLDLGENRIADTIPPWIGERLSDLEFLTLQSNNFHGGISNTLCQLPYLQVLNLAHNDLSGSIPHCFKNFTAMESTEPGTFQYSNYTYHDPVLHNFKAGIELEYSKNMESVKSISLSGNNLVGEIPDEIMGLVGLQTLNLSKNHLNGRIPKNIGNLKQLETLDLSMNELSGEIPPSLSSIYSLSFLNLSYNKLSGPIPSGNQLQTLNDPSTYEGNIGLCGKPFPNSCPAGESPTENGPVLDDKDYIIIYNTKNNKKIFFFKRQHHINHKTVQSQSLSSFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBL7</accession>
    <name>A0A068UBL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-stranded DNA binding protein Ssb-like OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021282001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBL7"/>
    <dbReference type="FunCoup" id="A0A068UBL7">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBL7"/>
    <dbReference type="Gramene" id="CDP05955">
        <property type="protein sequence ID" value="CDP05955"/>
        <property type="gene ID" value="GSCOC_T00021282001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBL7"/>
    <dbReference type="OMA" id="MASATKQ"/>
    <dbReference type="OrthoDB" id="2274046at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472:SF8">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="1">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="149" mass="16351" checksum="370EBF011FB225F8" modified="2014-10-01" version="1">MAATSSKTEDQPAAVAGGLRKPVFVKVENLKPGTNGHTLVVRVLSSKTVLQRGKSVSPHLRNTNIAECLVGDETACILFTARNDQVDVMKPGTTVILRNAKIDMFKGTMRLAVDKWGRIEVTQPAEFDVKEDNNLSLIEYELVNVVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBW8</accession>
    <name>A0A068UBW8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021014001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBW8"/>
    <dbReference type="Gramene" id="CDP05742">
        <property type="protein sequence ID" value="CDP05742"/>
        <property type="gene ID" value="GSCOC_T00021014001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBW8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="106" mass="12074" checksum="683ED4D0E5A956C8" modified="2014-10-01" version="1">MTNIFLTLCLFLLPVFFLLFRRRKGKIIRGASTGEQLLREKRLELSKGAPSHQGLISCLLSIPGEGNAEVLYEEEIIRNVLLMPKGWQIFWVAAMTRMDSSISHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCC2</accession>
    <name>A0A068UCC2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021143001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCC2"/>
    <dbReference type="Gramene" id="CDP05844">
        <property type="protein sequence ID" value="CDP05844"/>
        <property type="gene ID" value="GSCOC_T00021143001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCC2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="116" mass="13481" checksum="D6D09C690C907EF0" modified="2014-10-01" version="1">MEEAREDVREDEAAAVDDENKLDLLESDRGLSPSDSLFRDIDDFLSRNDFHNLSNFEGLQGASFSDFLLPFLLACIKKPMKTIIRRMNISSDYVEKNFSVCCFHFFKKRKVSNIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCL1</accession>
    <name>A0A068UCL1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00021361001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="gene ID" value="GSCOC_T00021361001"/>
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    <dbReference type="OMA" id="PKTGMWN"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
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        <property type="entry name" value="Znf_PARP_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01664">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP06017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="348" mass="39323" checksum="40DCB00008BDBC26" modified="2014-10-01" version="1">MASSSSAKMIAEYAKSGRSSCKKCSKTISASALRLGLVTRDARGFDMTKWHHLHCLPLSSHSGASPESIKGFSSLKSSDQEELKKLMKESVQALDKVLDGEKDSITETKEFKVLRRDDEDESYEMEKQKVKKKKLSESDKGSKLEITFSATEIKEKYKDAALLPQWKAFQTIIFLERVDGLHDSTKIAAFDFDGCLAKTAVNKIGADAWSLMYPSIPEKLQRLYDEGYKLVIFTNESNIERWKKKRQVAVDSKIGRIESFIKLVKVPIQVFIACGLSNCQPEDAYRKPKTGMWHVMEKHFNSGLLIDMDHSFYVGDAAGRPNDHSDADIKFAEAIGLKFYLPEQYFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD02</accession>
    <name>A0A068UD02_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00021428001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD02"/>
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        <property type="protein sequence ID" value="CDP06069"/>
        <property type="gene ID" value="GSCOC_T00021428001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD02"/>
    <dbReference type="OMA" id="RVSGCQD"/>
    <dbReference type="OrthoDB" id="10263919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD02"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="625"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP06069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="721" mass="80897" checksum="A2360B22E99A9FC4" modified="2014-10-01" version="1">MVKILDGANVLEEMNYGLLKDLRVELKDSDTEENGAFCFSFWLYLANYGSPLPCGILHQEHIDINSSVPFLLLNEKKKMMLLPVIFLHKEASMLVGLNPLTEVPSIVTQFDIPLKKWVHVGCEASQNSLRLRVNGEIVGEKHLTPVLNDELHADGMKRRALPCIIGEYQGFQGYVHFAKLSPSGLPLKTHCIEDPPLQLSIDSSSASDIEEDGDGVWSIVGGKASCRRNFSLDVTLLDAFDQPLNKEMEVVASLLYADNNEPVPETNDGEAPLLTSYDGIEYASSDRPSKLISGRASFKLKMSQLSSKCDNRLFRIRFEIPKIRYPFLEAFSPPIRCISRSRNARASSITLKKLPSGVHLLNGSQSPGLDDRSSELLNSVVREAKPSPSSKRVKLGQEKPFEIFADSFTSKRADKECKSYAFTTTEGNHTYGSNLVRKPENHDGSDNFSSDSETSETTKSDLMSIPSSTNQLSDMVVFKYCLGGLSERAVLLKEIALSAREEELVKFADQVSLFSGCSHHRHQIMIAKRLIEEGIEAWNLISQKNDHVLWENLLSGVKEHFVKIVPCGTRSLTHQDVELLRGISGCQELVSQDHFEKMWFWLYPVALSLSQVWINALWSSVSPKWIEGFITKEEAESSLQGPGGFQEPGTFVLRFPTSRSWPHPDAGNLVITYIGSDYAIHHRLLSLDLMYSSRDRTVRPLQDMLLEEPELSRLGRHDIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD72</accession>
    <name>A0A068UD72_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023395001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD72"/>
    <dbReference type="FunCoup" id="A0A068UD72">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD72"/>
    <dbReference type="Gramene" id="CDP06515">
        <property type="protein sequence ID" value="CDP06515"/>
        <property type="gene ID" value="GSCOC_T00023395001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD72"/>
    <dbReference type="OMA" id="RGHSTLW"/>
    <dbReference type="OrthoDB" id="758624at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008004">
        <property type="entry name" value="OCTOPUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31659">
        <property type="entry name" value="PROTEIN: UPF0503-LIKE PROTEIN, PUTATIVE (DUF740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31659:SF9">
        <property type="entry name" value="PROTEIN: UPF0503-LIKE PROTEIN, PUTATIVE (DUF740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05340">
        <property type="entry name" value="DUF740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="633" mass="70356" checksum="8AC0C81BCFD426E9" modified="2014-10-01" version="1">MNPTAADPAPPPPPPPQPPRSSFSCDRHLQEQFTGFCPSCLCERLTTLDQSSSNPSSSSRRPSTSSSSAAAALKSLFSSSSSKPSTSFTTTTTNPPPQPPPKPSKPASFFPELRRTKSFSASKHEGLGLNFSGAFEPQRKSCDVRVRNTLWTLFTLDDESKVTTSAKPSTSSSSLNPQHSILTKDTHDDFVNKPVFESKEEGEGEEEPQNEESECTPVVEEKGDINLEIVEEEDEEVVDFSTIKPMKDHIDLDSQAKKPSGGGGVREIAGSFWSAASVFSKKWHNWRRKQKMKKRSNGELSATLPVEKPISRQYRETQSEIADYGFGRRSCDTDPRFSLDAGRISFDDPRYSFDEPRASWDGYLIGRSFPRMPPMLSVVEDAPAVHVSRSDSQIPVEEPNVLGMNCPVNDDEAVPGGSAQTREYYSDSSSRRRKSLDRSSSIRKTAADVVAEIDEMKGASNARDANSSSLRDDYSETFELRSLRDNASVVGNGEGKGPKKSRRWSWKIWGFIHRRNGGNKDEDDDRDSKANGVERSYSESWQELRREGNGEVKDGINRKVFRSNSSVSWRNSSYIGGSFGSRNRSARYSPNNVDHGLLRFYLTPLRSSSRRGAPAKNRQNGSHTIARSVLRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFP9</accession>
    <name>A0A068UFP9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023318001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFP9"/>
    <dbReference type="FunCoup" id="A0A068UFP9">
        <property type="interactions" value="2983"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFP9"/>
    <dbReference type="Gramene" id="CDP06458">
        <property type="protein sequence ID" value="CDP06458"/>
        <property type="gene ID" value="GSCOC_T00023318001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFP9"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001096">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113263" checksum="154590133D6D21E7" modified="2014-10-01" version="1">MALSASDLPMMYTLLANSLSGDQGVRKPAEAALAQSENRPGFCSCLMEVITAKDIVSQVDIRLMASVYFKNSVNRYWRNRRDSLGISNEEKIYLRQKLLSHLREENDQIALTLAVLISKIARIDYPKDWPDLFSVLAQQLQSADILSSHRIFMILFRSLKELSTKRLTADQRNFAEISAKFFDYCWHLWQRDMQTILQGFSVLVQNSSLGASELRQDDLYLSCERWFLCSKIVRQLIVSGFSSDSKVIQEVRPVKDVSPMMLNAIQSILPYYASFQEQHPKFWDFLKRASIKLMKILVAIQLRHPYSFGHESVLPAVMNFCLKKIMDPEPYLLLFDQFLIQCMSMVKTVLECKEYKPSLTGRVIDENGATLEQVKKKVSSAVAGLLASLLPSDRVVLLCNILIKRYFVLKASDLEEWYQNPEAFHHEQDSVLWSEKLRPCAEALYIVLFENHSQLLGPVVVSILQEAMNGCPSSVNDITQALLLKDAAYGAAAYVYYELSNHLSFKDWFNGALSLELTNDHPNMRIIHRKVALILGQWISEIKDDMRRSVYCALIKLLQDRDLCVRLAASRSVYFHIEDANFSEHDFLDLLPVCWDLCFNLMEEVQEFDSKVQVLNTISVLIAHVNAVIPYTNKLLQFFQKAWEESSGESLLQIQLLSALKNFVCALGYQLPICYNMLLPILRSSIDANSPDELLEDSMQLWEATISHAPSMVPELLGCFPCLVEILEKSFDHLKVAANIIEGYVILGGSDFLTMHASNIAKLLDLVVGNVNDRGLLCILPVVDILIQCFPVDAPQLISSTLQKLILTCLTGKDDHDPSRTAVKAALAAILARTLVMNTNYLAQLTSEPWLILHLQRAGLSVEENILLCLVDLWLDKVDNVISIQRKTLGLALSVVLTLRLPQVLDRLDQILSACTSVILGESEDLTEEESSSDISSGQPHVPSREFRRRQIKLSDPINLVSLENSVRENLQACAALHGEAFNSAIGKMHPAALAQLKQALKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH67</accession>
    <name>A0A068UH67_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025414001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH67"/>
    <dbReference type="Gramene" id="CDP07910">
        <property type="protein sequence ID" value="CDP07910"/>
        <property type="gene ID" value="GSCOC_T00025414001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH67"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="53" mass="6171" checksum="5265D8250C38FB41" modified="2014-10-01" version="1">MVSRGKASLLSENYSCWLLEWMVVLHLWTTGQETCDPAPRKVIGKMRRTKLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHL7</accession>
    <name>A0A068UHL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00025111001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHL7"/>
    <dbReference type="FunCoup" id="A0A068UHL7">
        <property type="interactions" value="2104"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHL7"/>
    <dbReference type="Gramene" id="CDP07752">
        <property type="protein sequence ID" value="CDP07752"/>
        <property type="gene ID" value="GSCOC_T00025111001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHL7"/>
    <dbReference type="OMA" id="NGRHKEE"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000005">
        <property type="entry name" value="RNA binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000616">
        <property type="entry name" value="RNA binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF32">
        <property type="entry name" value="RNA BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="513"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="687" mass="75671" checksum="B58C01B90526993F" modified="2014-10-01" version="1">MDGAIGNGDERTFNVNFGSEGVSKLREDVKEKLKEYMGEYTDDTLVEYIIVLLKNGRRKDEARNELNVFLDDASDSFVSWLWDHLASNLDLYAQTHQSLSDGALKTSPIAIQQAGGNDSRLVESKSVNLKSNKSFKARHTREWKGQAIDEGEQPRLRSSVADGNHADKDSRKAGNEKIEVSPQPATRRKRNHPEEQLQSKREVVSQAPIAAPRRLLQFAVRDAVATSRPSTITAEPSLKRLRSVVSTTAEDSNLEEHPQKIRSVARVPNAMATAIKAIAEAAKDVRRVRSSGNVFDRLGRPKDVSETLNQSEEFGEDPAGEGQDGAYIREEGRPTYDHTNDYSRPYPNDVSLLQRNTRMVIDPASDNEDYDATMDEPQTGNGIGVSRMVPHSAANNADEIVIVPSKNQDQFGKISDTSHKIVSSSINLNTWKSPQHQGLRGTLNVDNHKSVQVNEALTSVPAGRLTKENSNSVAVANGNAQLEVDAPKESQKTHSSALGSYPIGRPTEDADSRTIFVNNVHFAATKDSLSRHFNKFGEVLKVIILTDAATGQPKGSAYIEFMRKEAAENALSLDGTSFMSRILRVIRKNSAQQEAFPIPTWPRIARGSPYAVSRFGRAPFSRGIGGAYRSRLLTKPGPRSFQWKRETQPTQTEILNPGSSNTAPSSISRSLTYVRPEPKTNESSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHZ5</accession>
    <name>A0A068UHZ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00025297001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipolytic acyl hydrolase (LAH).</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the patatin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHZ5"/>
    <dbReference type="Gramene" id="CDP07844">
        <property type="protein sequence ID" value="CDP07844"/>
        <property type="gene ID" value="GSCOC_T00025297001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHZ5"/>
    <dbReference type="OMA" id="TILAMSQ"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHZ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07214">
        <property type="entry name" value="Pat17_isozyme_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000005">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32176">
        <property type="entry name" value="XYLOSE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32176:SF92">
        <property type="entry name" value="XYLOSE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="6">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="6">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP07844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="44231" checksum="D51B687E52E021E0" modified="2014-10-01" version="1">MEGANSSPVQILPPTNGNLITILSIDGGGIRGIIPAAILDFLESQLQELDGEDARIADYFDVIAGTSTGGLITAMLTAPNEKNRPLYAAKEIKPFYLGNGPKIFPQKSGILGLIKPVQNFIPGPLYDGKYLHKILKEKLGQTRLRQTLTNVVIPTFDVKYLQPTIFSTYEVKASPLLDALLSDICIGTSAAPTYFPVHYFTNQDDKGNVWDFNLTDGGVAANNPTILAMSQVTKQMIKNDPDFSQMKPTDYARFLVISIGTGSAKIEKKFSAEMVNKWNPLGWVLNGTVPPLVEMFAQASGDMVDYQISVIFQALHSEANYLRIQDDTLTGQSASVDVATKENMEKLGEIGSNLLKKPVSRVNLLTGAVEQVENGGTNEEALKRFAKLLSDERRLRRSKSQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI17</accession>
    <name>A0A068UI17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-galactosidase beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00025458001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI17"/>
    <dbReference type="STRING" id="49390.A0A068UI17"/>
    <dbReference type="Gramene" id="CDP07937">
        <property type="protein sequence ID" value="CDP07937"/>
        <property type="gene ID" value="GSCOC_T00025458001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI17"/>
    <dbReference type="PhylomeDB" id="A0A068UI17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041392">
        <property type="entry name" value="GHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17834">
        <property type="entry name" value="GHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-galactosidase beta-sandwich" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="112" mass="12837" checksum="F472D5472F0A5F13" modified="2014-10-01" version="1">MSLLLSSQFSPHPILIRMFSIVMPLGNYQGAHVFKSKFGACALFLVNCNSQSLTRVAFGNMDYHLPPWSISILTHCKIMVYQHPSFSHLTHLIYVCSIHRLIYNLLIFIAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIG9</accession>
    <name>A0A068UIG9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027015001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIG9"/>
    <dbReference type="STRING" id="49390.A0A068UIG9"/>
    <dbReference type="Gramene" id="CDP08246">
        <property type="protein sequence ID" value="CDP08246"/>
        <property type="gene ID" value="GSCOC_T00027015001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIG9"/>
    <dbReference type="OMA" id="ELMHVED"/>
    <dbReference type="OrthoDB" id="1846188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIG9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF18">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="472" mass="53911" checksum="9F19E321660A092A" modified="2014-10-01" version="1">MSEAELDLVPPSFVQEGARKMGEKSWIINVNDKVGHLADITETEMKDWEQHSIYRLPACVTDLNKNAYKPRAISFGPYHHGEPNLKPMEIHKERALLHFLNRSEKSLEDYIGPLREVLQDLKDAYDILDDEWLQNSDAFLELMIRDGCFMIEVLRTSFADTQTGVVDYTHNDPIFSNHGKLYMLPYIKRDMLMIENQLPMLLLKTLLAVDNQNAQTTDEESINNLILKFYFPHSRPKILGKCMHVLDAYRRILLWTDPDGQKPTQGVCKRGPDDILSARELEESGIRIRKSDSTSLNDIHFDCDTGILRLPQITVDDVSETMFLNLVAFERFHVGAGNEVTDYIFFMDEIIDNAMDVNILQRHEIIENAFGSDKAVAKLFNSLTQDVALDENSRLTAVRQAINGYCKTKWHKWRAALIQTYFRSPWALISVVAAIVLFALTIAQTAYGALQYYEGLDNSPSPPPPPPPPHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIU6</accession>
    <name>A0A068UIU6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00026919001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIU6"/>
    <dbReference type="Gramene" id="CDP08172">
        <property type="protein sequence ID" value="CDP08172"/>
        <property type="gene ID" value="GSCOC_T00026919001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658008" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7598" checksum="E49751A72D5E0F81" modified="2014-10-01" version="1">MSLFLLPVFITLKSPKSFSAPNQHNTRSDTRTRTHTHCNSTDYRSRVRKQKPTRKPKDRKKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKD8</accession>
    <name>A0A068UKD8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein NRT1/ PTR FAMILY 2.7-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00028083001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKD8"/>
    <dbReference type="FunCoup" id="A0A068UKD8">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP08941">
        <property type="protein sequence ID" value="CDP08941"/>
        <property type="gene ID" value="GSCOC_T00028083001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKD8"/>
    <dbReference type="OMA" id="ICVAFNI"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP08941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62251" checksum="8E42FA6ADC5D5B0D" modified="2014-10-01" version="1">MDRTVLNSANGEDPEPTSISSRGKKGGWTTFPFTIATVAGIALAFGGLTGNLIVYLIQEFNIRSISAAKIFNVVNGCTTILPIAAAIIADSFTGCYSVIWISSLISSLGLLIIVLTAAISKLRPPHCENGSNLCKYPSEVQLAVLYIGLALGSIGMAGTRFTIGSMGANQFDKPKHQGIFFNWYIFTMYMATGISSTLIVYIENSVSWTLGFGICLAANIFALAIFLAGSGFYHHLKPQGSPFVRLARVIVASFRKRKMVLSLKREDYFQGPDYKMTTSPSKFFKFLNRAALRAEGETEPDGSTRQPWKLCTVQDVEDFKRIIKIFPLWSTGFFLSTPLVILGSLSVLQALAMDRHLGPHFQIPAGSVFLFTLMPTCFTVFLLDRFLFPLWEKFTGHPVRPLQRVGIGHLLDIVGLAVLALVEAKRLKIARLHDLQGQDNAVVPMSVFWLVPPLAIAGIGEAFFFPGQIDFYYQEFPASLKSTSTAAVALYMGIAYYLGNAVIDLVRRTRGWLPDDLNKGRLDNVYWLVCVLAGLNFCYYLVCSYFYKYQNVETVKVTDDSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN08</accession>
    <name>A0A068UN08_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028173001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN08"/>
    <dbReference type="FunCoup" id="A0A068UN08">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN08"/>
    <dbReference type="Gramene" id="CDP09008">
        <property type="protein sequence ID" value="CDP09008"/>
        <property type="gene ID" value="GSCOC_T00028173001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN08"/>
    <dbReference type="OMA" id="KAMDGRY"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN08"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001138">
        <property type="entry name" value="RNA-binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="92" mass="10347" checksum="1B211BAB1EED4B5E" modified="2014-10-01" version="1">MARRGLELFVSRLSFYTTAEELKSLFSPFGLVTQARLVIDPITRRTKGFGFVQFDSETDAQNALKAMNGRIVNGRLIFVEVAKTTRSENQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN38</accession>
    <name>A0A068UN38_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030050001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN38"/>
    <dbReference type="Gramene" id="CDP09649">
        <property type="protein sequence ID" value="CDP09649"/>
        <property type="gene ID" value="GSCOC_T00030050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN38"/>
    <dbReference type="OMA" id="PTQMHYA"/>
    <dbReference type="OrthoDB" id="1880841at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN38"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000343">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g58590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000361">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF427">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="87996" checksum="B85FBA87F7B3B0BE" modified="2014-10-01" version="1">MFQYGHLSRLAPALRLLKHFHSHPPFLSPTSAKCRPPLSQPPPNLLPLCASTQSLNQTKQAHAICIHHGLLPSSISICAALILRYAAFEKPDHHPSIIYSLFYQTLSCSPSSTFLYNTMIRAHSSLGLYDQGLKIYNEMVRNNVEVDNYTYPFVLKLCSERSGQQKGLEVHGTLIKFGFDEDLFVNNTLMLFYRNCEDVKVVQKLFNEMPERDVVSWNMMIRVFSDNGCDVEVIELFKKMVGESEFKPDAVSLVSILPVCAGEGTMMCVIHCYIVKVGFDVQVSVGNALINLYGKCGDVDGARQIFDEMVEKNDVSWNTIIAISGYAGCYREALDMFRLMVDEGVILSSVTVSSVLPVLVELGFVSKGRELHGFSMRRGMNADPFVANSLIDMYAKSGRPVDASNVFHNMDLINVVSWNAMVANFAQNGLELEAIECLRQMQFDGQIPNPITFTNVLPACARMCSLRLGKEIHGRLIRSGYHLDIFVSNALTDMYARSGCLDLARNVFLISSKDVVSYSILISGYSQTDSSNSLILFSEMGLQGIQHDIFSCMGVLSACANISAIKHGKEVHAFAIRRSLDEHLSVANSLIDMYTKSSRIDLAKKVFDRISNRDSASWNTMILGFGMLNEPDTAVNLFKTMREDGVEYNSISFLAVLSACSHGGLVEEGRRFFNDMLARGIKPSQKHYACMVDLLGRSGLIQDAIELVKSLPIQPDVNIWGALLGASRLHGDVETGCWAAENLLKLRPNHSGYHVLLSNMYAEAGKWEEADTVRELMRLIGVKKHPGCSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTI3</accession>
    <name>A0A068UTI3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034154001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTI3"/>
    <dbReference type="Gramene" id="CDP11696">
        <property type="protein sequence ID" value="CDP11696"/>
        <property type="gene ID" value="GSCOC_T00034154001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTI3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="160" mass="18605" checksum="4142F77D13E7EB46" modified="2014-10-01" version="1">MPDMLNPCGNSLLFFFSNEMDVIKHFALFPEWGKLNIDTNITVYLRMLLCLSCLVQDSSGLQSLMVFSLFFFGVLFRVGIMVFSLSLLWLFCKFCQMLVLGTLHVFLHMCEFKCSGVSKNSFLWGQNAEYLSLSYRTITRSFFWCMLVSKSFSWDDRPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UU17</accession>
    <name>A0A068UU17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Extra-large guanine nucleotide-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00034176001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-alpha family. XLG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UU17"/>
    <dbReference type="FunCoup" id="A0A068UU17">
        <property type="interactions" value="1564"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UU17"/>
    <dbReference type="Gramene" id="CDP11709">
        <property type="protein sequence ID" value="CDP11709"/>
        <property type="gene ID" value="GSCOC_T00034176001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UU17"/>
    <dbReference type="OMA" id="HVRIDSK"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UU17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000005">
        <property type="entry name" value="Extra-large guanine nucleotide-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001044">
        <property type="entry name" value="Extra-large guanine nucleotide-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF334">
        <property type="entry name" value="EXTRA-LARGE GUANINE NUCLEOTIDE-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="403"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="526"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="74085" checksum="760E8F66350BF7E6" modified="2014-10-01" version="1">MGSMPEGRKCVTCIGEPIDESKRSKLGKHSRVLSRLLSPLEVKHIMRAEKECAANQLRPEQLIVNGFPLKPEEMAELFGCPLPPRKLKPGRYWYDKESGMWGKEGEKPDRVINSNLNFTGKLSPHASNGNTEVYINGREITKRELRVLKLANVQCPRDTHFWVYDDGRYEEEGQNNIRGNIWEKASTRFVCSLFSLPVPQGQPYPQRDEPSNYTTVPNYLEQKRTQKLLLIGLQGSGTSTIFKQAKFMYGNKFTAEELLDIKLMIQSNMYKYLSILLDGRERFEEEALSRTKELTLNEQTTETGDDIDSSDSNQCVYSLNPRLKHFSDWLLDIIATGDLDAFFPAATREYAPLVEEVWRDPSIQESYRRKDELHFLPDVAEYFLSRAVEVSSNEYEPTERDILYAEGVTQGNGLAFMEFSLDERSPMSETYTDNLDAPPPPLTRYQLIRVNAKGMNEGCKWVEMFEDVRVVVFCAALSDYDQISVAPEQGGSGVLLQNKMMQSKELFETMIRHPCFKDTPFVLILNKYDLFEEKVNRAPLSTCEWFTDFSPVRPHHNNQSLAHQAYYYVAMKFKDLYASLTARKLFVWQARARDRVTIDEAFKYIREVVKWDEDREENFYGAEGDSFYSTTDVSSSPFVRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUI4</accession>
    <name>A0A068UUI4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035580001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUI4"/>
    <dbReference type="FunCoup" id="A0A068UUI4">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUI4"/>
    <dbReference type="Gramene" id="CDP12175">
        <property type="protein sequence ID" value="CDP12175"/>
        <property type="gene ID" value="GSCOC_T00035580001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUI4"/>
    <dbReference type="OMA" id="RDSYCKV"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUI4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF3">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="177"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="606" mass="67111" checksum="A32BAE4808EF7AE1" modified="2014-10-01" version="1">MKGYCHGDPANVELPNEGHPVKQKSLPLFFSVLCIVVLFCSKFRVAGNDEGKLLAYNESTSNFTECNNKLSNCTSPLAENEIKTYAKCMPVEFNVCVITDNSSIHDDHWKKLEYSPLKISRLEEVISSALGDSKCSCEVKQLEIHEENRSQQLENGTTHLAYPNLEDFRNMTGQSKGSSSPSQLINVTQRLEPDGKPYNYAAASKGAKVVAHNKETNGASNVLGKDHDKYLRNPCSVGGKFFVIELADETLVDAVKIANFEHYSANFKEFELSGSLVYPTETWTSLGTFVAANVKHAQCFKLPEPKWVRYLKLSLLSHYGSEFYCTLSLVEVYGVDAIEQMLEDLIVTSKESPTNALPNRNSTASLRVPDPGSSNNQVDDVVQSVVEPAGKAIDSVKEEVSIDMPRKSATISSSPDPILNVRQQPNGRVHADAAVKILLQRVRSLELNLSVLEEYIKELNRRQGNILPDLEKEMVKISLLLESSKLEIKYLLEWKGTMEKGITDLESWKATIAAQLDLLIQENGLLRLDVEQVTKDQASLEKKEIAVLAISFSFACAAVLQLVLNRSLTIFRGSSPDEIPHASTSSSRGWIVILLSSGLTILIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUT8</accession>
    <name>A0A068UUT8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00033623001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Carretero-Paulet L."/>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
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                <person name="Aury J.M."/>
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                <person name="Jahn K."/>
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                <person name="Perrotta G."/>
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                <person name="Rouard M."/>
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                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
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                <person name="Da Silva C."/>
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                <person name="De Bellis F."/>
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                <person name="Garsmeur O."/>
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                <person name="Jahn K."/>
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                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYC0"/>
    <dbReference type="Gramene" id="CDP13545">
        <property type="protein sequence ID" value="CDP13545"/>
        <property type="gene ID" value="GSCOC_T00038529001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYC0"/>
    <dbReference type="OMA" id="THHIYSV"/>
    <dbReference type="OrthoDB" id="726732at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYC0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000023">
        <property type="entry name" value="heparanase-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363:SF17">
        <property type="entry name" value="HEPARANASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363">
        <property type="entry name" value="HEPARANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658358" description="Heparanase-like protein 3" evidence="11">
        <location>
            <begin position="27"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56084" checksum="42B02E4C05A0371F" modified="2014-10-01" version="1">MASLLNILGLCLWLFLTCQDSKKVVSQNITQGSLFIDGSASVGSTDENFICATLDWWPPEKCDYGSCSWGNASLLNLDLSNKVLLNAVKAFSPLKIRLGGTLQDKVVYQNADGPRSCNEFVRSMEMFGFTEGCLPMSRWDELNKFFTLAGAEVIFGLNALHGRTIGPGNNVIGPWNSSNAESLIRYTVSNNYTIYGWELGNELSGNGIGASVAADQYASDVIHLQNIVQDVYKDFQSKPLVLGPGGFFDAGWFSQFINLASNSLQAVTHHIYNLGPGSDDHLVDKILDPSNLDGGSQPFRDLQRVLKTSGASTKAWVGEAGGAYNSGRNLVTNTFAFSFWYLDQLGMASSYDTKAYCRQTLVGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNVLATNLTAIKNLRAYAHCSKLSHGITVLLINLDAYATVQVGLSFTRNNLDSSMRKEYHLTAKHGNIHSQIVLLNGKILSVDSSGTIPPLEPRTVNPSDPITIAPFSIVFADIPNILVPACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYU9</accession>
    <name>A0A068UYU9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00038600001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYU9"/>
    <dbReference type="FunCoup" id="A0A068UYU9">
        <property type="interactions" value="2938"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYU9"/>
    <dbReference type="Gramene" id="CDP13596">
        <property type="protein sequence ID" value="CDP13596"/>
        <property type="gene ID" value="GSCOC_T00038600001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYU9"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYU9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="11">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="378" mass="43591" checksum="F275EC30D542F16C" modified="2014-10-01" version="1">MEEEKEERKAEAKPRKHKGKHDKPKPWDDESIDHWKIDKFDPSWNETGMLEVSSFSTLFPQYREKYLQECWPIVKGALKEFGVACELNLVEGCMTVSTTRKTRDPYIIIKARDLIKLLSRSVPAPQAIKILNDEMQCDIIKIGNLVRNKERFVKRRQHLVGPNSSTLKALEILTGCYILVQGNTVAAMGSFKGLKQVRRIVEDCILNKMHPLYHIKILMLKCELAKDPALANENWDRFLPTFKKKNVKQKKVKSKEKKPYTPFPPSQQSSKIDLQLESGEYFLTDKKKLAKKWQEKQEKQAEKTAENKRRREEAFIPPEEVKKHGSHSLNADRHDDVSAIALSLKKKVKEFGKKKSAEKIDPQAYIAAVGKLSAEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0T4</accession>
    <name>A0A068V0T4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS17c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00040540001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0T4"/>
    <dbReference type="FunCoup" id="A0A068V0T4">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0T4"/>
    <dbReference type="Gramene" id="CDP14251">
        <property type="protein sequence ID" value="CDP14251"/>
        <property type="gene ID" value="GSCOC_T00040540001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0T4"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0T4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000236">
        <property type="entry name" value="30S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_uS17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_uS17_bact/chlr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004123">
        <property type="entry name" value="PRK05610.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="114" mass="12708" checksum="D58898309B5A85D4" modified="2014-10-01" version="1">MKPVVGMVVSNKMQKSVVVAVDRLFHHKLYNRYVKRTSKFMAHDEHNQCNIGDRVKLDPSRPLSKRKNWVVAEILKKARIYTPQSAADSTNMADLSSSMSSGSTKPAQNSSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0Z1</accession>
    <name>A0A068V0Z1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040413001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="8"/>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0Z1"/>
    <dbReference type="FunCoup" id="A0A068V0Z1">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0Z1"/>
    <dbReference type="Gramene" id="CDP14164">
        <property type="protein sequence ID" value="CDP14164"/>
        <property type="gene ID" value="GSCOC_T00040413001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0Z1"/>
    <dbReference type="OMA" id="HNGPEEK"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0Z1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000012">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000109">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000229">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF30">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] GPDHC1, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="9">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="10">
        <location>
            <begin position="275"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="463" mass="51669" checksum="465E5245C91DBF25" modified="2014-10-01" version="1">MVGSIEVANHKVHLNGAMQHQNGFEEKLDELRRLLGKADGDLLRIVGVGAGAWGSVFAALLQDSYGQFRDKVQIRIWRRPGRAVDRATAERLFEVINSREDVLRRLIRRCAYLKYVEARLGDRTLYADEILKDGFCLNMIDTPLCPLKVVTNLQEAVWDADIVVNGLPSTETQEVFVEISRYWKERITKPIIISLAKGIEAELDPVPHIITPTQMIIRASGVPIENILYLGGPNIASEIYDKEYANARICGAEKWRIPLAKFLRQPYFIVWDNSDLVTHEVMGGLKNVYAIGAGMIAALTNESATSKSVYFAHCTSEMIFITHLLTEEPEKLAGPLLADTYVTLLKGRNAWYGQMIAKGELSLDMGDSISGKGTIQGVSAVGAFYELLSQSSLSVLHPEDNKPVAPVELCPILKTLYKILITREQGVRAILQALRDENLNDPRDRIEIAQTHAFYRPSLLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V100</accession>
    <name>A0A068V100_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M41 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038570001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V100"/>
    <dbReference type="FunCoup" id="A0A068V100">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V100"/>
    <dbReference type="Gramene" id="CDP13573">
        <property type="protein sequence ID" value="CDP13573"/>
        <property type="gene ID" value="GSCOC_T00038570001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V100"/>
    <dbReference type="OMA" id="WERDWEV"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V100"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042651">
        <property type="term" value="C:thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048366">
        <property type="term" value="P:leaf development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000007">
        <property type="entry name" value="ATP-dependent zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33471">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33471:SF7">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44034" checksum="939A85429349842A" modified="2014-10-01" version="1">MMSRLLCSSPHPPLPLHLPLEHVPNSYCQSPLAEFRPRPLQLQSPPPTTLVFIGRSSRRKSTGRGRGRALREWQDYEEAVKDKDLARALRLLKENSSIEPNDGGALQRKGDWQVLDTCLNADDMRLVASAYTFLKDQGRLPNFGKCRNIVLEGPREITPNVLTSATGLEVSKLSPKKWGLSGSSSVLLIALLAGVSFLLNQGIDIRPNLAAVLGLAMLDAILLGGSCLAQISSYWPPYKRRILVHEAGHLLVAYLMGCPIRGVILDPIVAMQSGIQGQAGTQFWDERLQNELAEGRLSGSSFDRYCMVLFAGIAAEALVYGEAEGGENDENLFRSICVLLDPPLSVAQMSNQARWSVLQSYNLLRWHKHAHRAAIRALETGCSLSTVIKIIEEAMSLKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1Z2</accession>
    <name>A0A068V1Z2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00042254001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1Z2"/>
    <dbReference type="STRING" id="49390.A0A068V1Z2"/>
    <dbReference type="Gramene" id="CDP14795">
        <property type="protein sequence ID" value="CDP14795"/>
        <property type="gene ID" value="GSCOC_T00042254001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1Z2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1Z2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF148">
        <property type="entry name" value="CYTOCHROME P450 72A15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="19259" checksum="791CA3482160B619" modified="2014-10-01" version="1">MVAWFAKVGKVCLSWTGTRSRLIMGKAELMRLTLNDKDGHFQKPPQNPLVDLLTLGVSTLEGEKWAKRRRLITPAFHHEKLPKMLVASDGWSEIDINPELQSLSTDVISRAAFGSSYKEGKKIFELQKDHRVLDTSATAIFPAQCSVNGFKKWIKTCERHTNYTEDQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3S0</accession>
    <name>A0A068V3S0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042976001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3S0"/>
    <dbReference type="STRING" id="49390.A0A068V3S0"/>
    <dbReference type="Gramene" id="CDP15301">
        <property type="protein sequence ID" value="CDP15301"/>
        <property type="gene ID" value="GSCOC_T00042976001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3S0"/>
    <dbReference type="OMA" id="VEGFLTH"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3S0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000047">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF229">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 73C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="221" mass="24622" checksum="77524F49C35573C1" modified="2014-10-01" version="1">MKWLDTWEPESVIYACLGSITRLGTSQLIELGLGLESSGRPFVWVTKDASDEFRKWLIEEKFEERTKGRGLLIHGWAPQVLILSHPSIGGFLTHCGWNSTIEGISSGAPMITWPLFAEQFMNEKLVLYVLKTGVKAGVESSVYIGHEEDVGVQVTRDNTKTAIEALMDKGGEGQMRRKRAAELKKMARKAADEGGSSHLNIEQLIKDIMEKVRTKSITDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3T6</accession>
    <name>A0A068V3T6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF632 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041068001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3T6"/>
    <dbReference type="STRING" id="49390.A0A068V3T6"/>
    <dbReference type="Gramene" id="CDP14548">
        <property type="protein sequence ID" value="CDP14548"/>
        <property type="gene ID" value="GSCOC_T00041068001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3T6"/>
    <dbReference type="OMA" id="QTWKVML"/>
    <dbReference type="OrthoDB" id="1893612at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3T6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF17">
        <property type="entry name" value="OS09G0542500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="2">
        <location>
            <begin position="249"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="82115" checksum="A739E70CE3D68793" modified="2014-10-01" version="1">MGCVASRLEEEEEVVSICRDRKHQLKLAVERRYALADAHYRYCQALYGVSAAIRLFVARHSSPASPFMITFPPPTPPSPPPENVVSNPLFLQQTPSEPTKEALTCESSTASDSSEEEIEERVEKEEPPSCGYFYMEMPQSMPSPHRDFGWDFFNPFTSVRPEIINGYNRISEEDLRVVREREGIPELEEEGERFEEESNAVVVEEKLGGRHHEESSRVEVAKAVNDSNVSQVEQKGLTVIDTPVRGRELLEALQDIEDHFIRAYDSGKELSRMLEVNRVQLQSNLEEIKENSTKMIQAITWRSTSSRSSSCKSLVASSSKNCLTWTEFKNDLFDDYGGMDSGSHSLTLGRIYAWEKKLYEEVKAGDNTRQLYERKCNQLRNQDARGVEGATVDKTRAAVKDLYSRILVAIRSAETISQRIEKLRDEELQPQIMELLQGMMRCWKAMLESHEIQNKIMFEVKTFTCPTFGKFCNDSHRLSTLQLGAELRNWRTCFTEYVASQKAYVEALHGWISKFIVPEVEFYSRSRISAPPCRENGPPLLTICRDWLASLDKLPDKDVGSALRSCEKDIRALWVQQGEEQQQKRKVDSLSKELDRKILVFQKAENKFHELKSTDHKLDLESDRGAECFKERKDLLDNFRGKVDMEKENHQNCMQETQRITLNGFQTGFGRVFESMTEFSKITLKMFNDLSSSSHDAEKFGSVSYSEGSQLEDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5E2</accession>
    <name>A0A068V5E2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016957001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739197">
        <property type="protein sequence ID" value="CDP16005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5E2"/>
    <dbReference type="FunCoup" id="A0A068V5E2">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16005">
        <property type="protein sequence ID" value="CDP16005"/>
        <property type="gene ID" value="GSCOC_T00016957001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5E2"/>
    <dbReference type="OMA" id="HTQMLIN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5E2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001093">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g34400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000427">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF543">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58675" checksum="5782A4DC3E651471" modified="2014-10-01" version="1">MKSLGVKPDNFTYPFVFISCGNLLDFGHGRLAHCEVWKNGLWMDFHVCHSLITMYSRFGELSFARKVFDEIPVRDLVSWNSMISGYSRAGFAGEAVELFYKMRNEEVAPDEMTLVSVLGACGDLGNLDLGSSIEKYVVEKSMEMNSYMGSALIDMYGKCGDLGSARRIFDNMGKKDVVTWNAMITGQVLIIQTEQFLFRLLLFFTSDRYAQNGLSDKAMCLFNAMKAAGVDVDKITVIGVLSACASVGALDFGKSIYKYASQSGLTDDIYVGTALIDMFAKCGNLDLAFQVFGDMPIKNEVSWNAMISALAFHGQAQEALSLFERMLREGGSTSCPNDITFVGLLSACVHAGLVDEGCHLIDLMSSSFGLVPKIEHYSCMVDLFSRAGRVYEAWNLIEKMPEKPDEVLLGALLGACNKIKNVDVGERVMQLLLEMEPSNSGNYVIASKIYANQDRWVDSARIRLLMRQKGISKTPGCSWIEMDNKLLEFHAGETLHSAQKVYQVLNMLYKEMMMEGGMSDSYVHLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V637</accession>
    <name>A0A068V637_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017181001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739201">
        <property type="protein sequence ID" value="CDP16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V637"/>
    <dbReference type="Gramene" id="CDP16121">
        <property type="protein sequence ID" value="CDP16121"/>
        <property type="gene ID" value="GSCOC_T00017181001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V637"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="62" mass="6561" checksum="3F44B9AC0F4EF060" modified="2014-10-01" version="1">MYISELAIITQVANDVTHGINIIFGERDEIEIGDIRPRPAAEQKEAFCGGGTAGGGGINSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6H3</accession>
    <name>A0A068V6H3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017303001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6H3"/>
    <dbReference type="STRING" id="49390.A0A068V6H3"/>
    <dbReference type="Gramene" id="CDP16201">
        <property type="protein sequence ID" value="CDP16201"/>
        <property type="gene ID" value="GSCOC_T00017303001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6H3"/>
    <dbReference type="OMA" id="CLEMDKV"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6H3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045182">
        <property type="entry name" value="JINGUBANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844">
        <property type="entry name" value="F-BOX AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF213">
        <property type="entry name" value="OS01G0232200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="394" mass="44359" checksum="1E8D042F6F4B09D8" modified="2014-10-01" version="1">MDYNTRKSLCTFMDEERKAKQSPPRLSFKSFEQISDRDLNYSHSRSSSTAAGMYSLMPPPSPDSPWTLSPLQTPSPSVLYHCIASLHRHEGIIYSIAVSRGIVYTGSESSRICAWRQPDCTERGYIKANCGEVHCVSCMGYYHAEGLLYTGSWDKTVKAWRVSDGKCVDSFLAHEDSVNAIVINQEDGCVFTCSSDGSVKIWRRVYDQSSHTLTMTLKFQPSPVNALALSTSHSSCFLYSGSSDGFINFWEKEKMSSRFNHGGFLQGHRFAVLSLVAIEKLIFSGSEDTTIRIWRREEGSYYHECLAVLDAHRGPVRCLAACLEVDKLMVIGFLVYSAGLDQTFKLWRVKVLPDEKNVCMEGTGRSDKMRITEYEMSPVLSPSWVEKKRQGNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7R2</accession>
    <name>A0A068V7R2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00019016001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May be involved in plant defense signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739217">
        <property type="protein sequence ID" value="CDP16592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068V7R2"/>
    <dbReference type="FunCoup" id="A0A068V7R2">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7R2"/>
    <dbReference type="Gramene" id="CDP16592">
        <property type="protein sequence ID" value="CDP16592"/>
        <property type="gene ID" value="GSCOC_T00019016001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7R2"/>
    <dbReference type="OMA" id="KSRCKNE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7R2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="91"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP16592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="424" mass="47060" checksum="61DD8E8B9DE84365" modified="2014-10-01" version="1">MKDSNSKPWMPFTANCCTVEDHTVFGNFSRCRPSRSEFSKNIAPMPSFRRLSFSDLSSSSSARINEDLAQSFGPDLFDFQLSELRAITQNFSSNFLLGEGGFGTVHKGYVDDNFRPGLKAQAVAVKLLDIEGLQGHREWLAEVIFLGQLRHPNLVKLIGYCCEDEERLLVYEFMARGSLENHLFKRLSVSLPWGTRLKIAIGAAKGLAFLHGAEKPVIYRDFKTSNILLDSDFNAKLSDFGLAKMGPEGSNTHVTTRVMGTYGYAAPEYVSTGHLTTKSDIYSFGVVLLELLTGRRAMDKTRPKTEQSLADWAKPYLTSSRRLRCVVDPRLSGQYSVKGAKEMAHLALQCVSMNPRDRPKMPVIIETLESLQNLRDMAVTCGQWPASPKSHKIAVCNARGKGEKGQGIFLTRSAILASACPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7S1</accession>
    <name>A0A068V7S1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00019039001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739218">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CDP16602"/>
        <property type="gene ID" value="GSCOC_T00019039001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7S1"/>
    <dbReference type="OMA" id="VANICAY"/>
    <dbReference type="OrthoDB" id="1727045at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7S1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
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    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="174"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="340" mass="36637" checksum="4920F52084E1F447" modified="2014-10-01" version="1">MVIVECANVGNSTLFKAASDQGMSFMVFVVYSFGLCSLALIPIAFIFHRNTPLPRFTLPVFGRVCLLGVLGFAAQMLGCKGLEYGSPTLSYALSNLLPAFTFALAIIFRMEKLDLKSFTSQAKILGTLVSISGALVVVLYKGLPVIRVIRTSSQYQSLNQPVGLVSSQSNWALGGLLLALDYLVLSIWYIVQTQTVKMYPAEFLVVLFYTAGVTIVSAPVCFFLEPDLKTWSISTTIMLISLLYAAIIGTGFGTVVHTWGLKVKGPVYVALFRPLSIAIAAFMGVVFLGDTLYLGSVIGAILISIGFYVVSWGKAQEEMSEDGGVLRIESAASENVPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7S3</accession>
    <name>A0A068V7S3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Agenet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019357001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739221">
        <property type="protein sequence ID" value="CDP16825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7S3"/>
    <dbReference type="STRING" id="49390.A0A068V7S3"/>
    <dbReference type="Gramene" id="CDP16825">
        <property type="protein sequence ID" value="CDP16825"/>
        <property type="gene ID" value="GSCOC_T00019357001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7S3"/>
    <dbReference type="OMA" id="WANGKWI"/>
    <dbReference type="OrthoDB" id="2020707at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7S3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd20406">
        <property type="entry name" value="Tudor_Agenet_AtDUF_rpt2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917:SF147">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agenet" evidence="1">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="122" mass="14304" checksum="633D9742589A1BAA" modified="2014-10-01" version="1">MTKDKTQFFKEADISCIKPSPPKIHQVEPFEVYTQVDAWYNNGWWVGLISKVLRNFKYVTYFKTSNEEMEFGHYDLQPHQEWIRGKWIIASKKKSKLGKLRGQIGVVLAPCFCSGMKIEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8N1</accession>
    <name>A0A068V8N1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00005061001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8N1"/>
    <dbReference type="Gramene" id="CDP17135">
        <property type="protein sequence ID" value="CDP17135"/>
        <property type="gene ID" value="GSCOC_T00005061001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8N1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="70" mass="7610" checksum="A44E654B22934242" modified="2014-10-01" version="1">MWILNWVVSGTFADLHQDPDPPHHLARNVLTKAQKGAARVRVKAGVGAVLVVGAKLHQGELWYSLVFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8Y6</accession>
    <name>A0A068V8Y6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3531 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00018256001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739207">
        <property type="protein sequence ID" value="CDP16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8Y6"/>
    <dbReference type="FunCoup" id="A0A068V8Y6">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8Y6"/>
    <dbReference type="Gramene" id="CDP16398">
        <property type="protein sequence ID" value="CDP16398"/>
        <property type="gene ID" value="GSCOC_T00018256001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8Y6"/>
    <dbReference type="OMA" id="IGDWEEG"/>
    <dbReference type="OrthoDB" id="2014339at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8Y6"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021920">
        <property type="entry name" value="DUF3531"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46737">
        <property type="entry name" value="OS02G0827600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46737:SF2">
        <property type="entry name" value="OS02G0827600 PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12049">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29735" checksum="8B363F8A3109EBBC" modified="2014-10-01" version="1">MPNSRDLTNIDDNNGGVLEGQTSKGSGTTARGRRLIKVREEKRKREYDRLHNYPAWAKVLEDACKNDAELRAVLGDTIGNPELMRKRVEERVRRKGRDFQKSKTGSVLAFKVSFRDFNPLDSYIWFELYGSPSDRDVDLLGSVIQSWYIMGRIGAFNSSNLQLANSSMEYDPLYDADKGFKVMPSSFHDISDVEFQDNWGRIWVDLGTSDFFSIDILLNCLTVLSSEYVGIQQVIFGGRKIGDWEEGMTSPEYGYKFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8Y7</accession>
    <name>A0A068V8Y7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00005039001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
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        <property type="protein sequence ID" value="CDP17116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CDP17116"/>
        <property type="gene ID" value="GSCOC_T00005039001"/>
    </dbReference>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to stress"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LEA_3a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33509">
        <property type="entry name" value="LATE EMBRYOGENIS ABUNDANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33509:SF28">
        <property type="entry name" value="PROTEIN SENESCENCE-ASSOCIATED GENE 21, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LEA_3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="99" mass="10591" checksum="F0BE802B556ED8A8" modified="2014-10-01" version="1">MARSFPNAKLISAFVVQRISVAASRHARGYAAGASQGAVPGSMRGGSNANMMRKKGGEESSSKTTSWVPDPVTGYYRPETHAAEIDAAELRNMLLKHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V924</accession>
    <name>A0A068V924_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00018328001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type IV zinc-finger family. Class B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739209">
        <property type="protein sequence ID" value="CDP16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP16433"/>
        <property type="gene ID" value="GSCOC_T00018328001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V924"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V924"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF30">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="126" mass="14098" checksum="FCE68F9FEA66762C" modified="2014-10-01" version="1">MFTMIWLDWSKVISGHKKSQYLDSSSSPSASSSKQLKSCSDCHTTRTPLWRGGPAGPKSLYNACGIKYNKKRRELLGLDRGRNDKGKKKRKSKMVLRRSGKLMGKLREEEQAAILLMALSCGSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V945</accession>
    <name>A0A068V945_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00004923001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V945"/>
    <dbReference type="FunCoup" id="A0A068V945">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V945"/>
    <dbReference type="Gramene" id="CDP17024">
        <property type="protein sequence ID" value="CDP17024"/>
        <property type="gene ID" value="GSCOC_T00004923001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V945"/>
    <dbReference type="OMA" id="EMFGCFL"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V945"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000235">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="17">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP17024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="124" mass="14249" checksum="E98991C839898497" modified="2014-10-01" version="1">MGKGGTSISFKDQFTFEERCAESQEMMAKYPDRLPVVVEKYLKTDLPDMEKKKFLVPRDMSVGQFIHVLSGRLHLAPGKALFVFVENTLPQTSSLMQFVYESYKEEDGFVYMCYSSEKTFGCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAG1</accession>
    <name>A0A068VAG1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calmodulin-binding family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00011050001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739252">
        <property type="protein sequence ID" value="CDP17564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAG1"/>
    <dbReference type="STRING" id="49390.A0A068VAG1"/>
    <dbReference type="Gramene" id="CDP17564">
        <property type="protein sequence ID" value="CDP17564"/>
        <property type="gene ID" value="GSCOC_T00011050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAG1"/>
    <dbReference type="OMA" id="NLANKQR"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF14">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP17564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66469" checksum="4E67186384E480A5" modified="2014-10-01" version="1">MGVSFSCLLAAYCDLQDGLDSVIVKSIGFSGDDEKKTPEWSMGISSQDSESKAFLSLDYGNCQFVIDTETEEMGNQSLKQSMATVKVPQLPILDCSNPKHEAAVKLQKVYKSFRTRRKLADCAVLIENSWWKLLDFAELKHSSISFFDLDKHESAISRWSRARTRAAKVGKGLSKNGKAQKLALQHWLEAIDPRHRYGHNLHFYYVKWFHSQSKEPFFYWLDIGEGKEVNLVEKCPRSKLQQQCIKYLGPMERKAYEVAVEDGKFFYKQTGELLDTSEEPKAKWIFVLSTTRTMYVGKKKKGTFQHSSFLAGGAALAAGRIVVENGILKAVWPHSGHYRPTPENFQDFISFLRDNNVDLTDVKLDSVDEDESFGRTSSGHLRNNSSEEDLADKIDLNIEESDVVDSNIERINSEKGLNKAPAELTQSRPLNCFASKLTNLQIPSKDDLVERFKSESELVQLDPNSLPPESPADGYETAEESSESEKPRPNLSTKELDATKGHAVSEDSILKRISPHSGLKPFQLGNKLSCKWSTGAGPRIGCLRDYPSELQSHALEQANLSPRSACILHRTGHHRRPQSSPLCKKEVHFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB76</accession>
    <name>A0A068VB76_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00003937001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB76"/>
    <dbReference type="FunCoup" id="A0A068VB76">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB76"/>
    <dbReference type="Gramene" id="CDP17809">
        <property type="protein sequence ID" value="CDP17809"/>
        <property type="gene ID" value="GSCOC_T00003937001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB76"/>
    <dbReference type="OMA" id="FFHESCN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF113">
        <property type="entry name" value="CARBOXYLESTERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP17809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="351" mass="38669" checksum="F4ABCC491C6929DB" modified="2014-10-01" version="1">MSEQQATTPELSREDAYKFLNLLPNPDGSFNRLNQLPTLPPTPEIPPNHQDLAAPPLSLSKDIPLNPKTNTFIRLFRPVNPPPNTKLAIIIYFHGGGFVLLSATDPIFHGSCSTMAAHVPALVASVEYRRAPEHRLPAAYDDAMDAIMWVKDQASGGKENGCDPWMQEYADFSKLFLMGSSAGGNMVYHAALRALDVDLAPVQISGLIMNEPFFGGVQRSESEFRQKHDKIAPLHATDLLWYLSLPEDATRDHEYCNIAASVASQKDKIGRLPRCLVRGYGGDPFVDRQKELVKVLEGGGVEVVAAFSEDGYHAVEVFDPKMAQILYDDVKNFVTFSSSAPENLNPEKSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC18</accession>
    <name>A0A068VC18_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S19-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00004728001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739316">
        <property type="protein sequence ID" value="CDP18395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC18"/>
    <dbReference type="FunCoup" id="A0A068VC18">
        <property type="interactions" value="2366"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VC18"/>
    <dbReference type="Gramene" id="CDP18395">
        <property type="protein sequence ID" value="CDP18395"/>
        <property type="gene ID" value="GSCOC_T00004728001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC18"/>
    <dbReference type="OMA" id="YYTRTAS"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC18"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF24">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES19X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP18395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15877" checksum="DF5B2285DEA05E40" modified="2014-10-01" version="1">MESARTVKDVSPHEFVKAYAAHLKRSGKIELPPWTDIVKTGTLKELAPYDPDWYYIRAASMARKIYLRGGLGVGAFRRIYGGSKRNGSRPPHFGKSSGSVARHILQQLQAMKLIDHDPKGGRRITSNGQRDLDQVAGRIAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCX8</accession>
    <name>A0A068VCX8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00007262001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739319">
        <property type="protein sequence ID" value="CDP18442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCX8"/>
    <dbReference type="Gramene" id="CDP18442">
        <property type="protein sequence ID" value="CDP18442"/>
        <property type="gene ID" value="GSCOC_T00007262001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCX8"/>
    <dbReference type="OMA" id="NWRIFIC"/>
    <dbReference type="OrthoDB" id="687555at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCX8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000565">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase protein FLORAL ORGAN NUMBER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057:SF18">
        <property type="entry name" value="REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655766" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="9">
        <location>
            <begin position="31"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP18442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="551" mass="60540" checksum="B62AC561A43A54A4" modified="2014-10-01" version="1">MWGFRSSSTLASIFLLLSVAVNLSVNHVSAAKQSQNETDRLALLEFKKQIYDDPFGALNSWNHSQHHCQWEGVTCGTRHQRVIALILRHKQLSGTISPHVGNLSFMRSIQLAENQFQGEIPQEFDRLLRLRVLNLSSNAISGKIPANLSYCSELLEIFYLLGNNLTGEIPSSIGNLSSLTQLTVDFNNLEGNLPMEMGLLKRFAGLGAAENKLSGIIPASIFNSSAITVISVGGNSFHGSLPTNIGLTLPNLEGLYLGENEFYGNFPTSITNASGLKILDLSRNKFEGQVPANFGDLTQLEIVNLYNNLIGNNSTGDLDFIASLTNCSDLRILSLSYNKFGGNIPTVMANLSNQLTELYLGGNQLSGTIPEGFGNFVHLIQLGLELNSFPGIIPRDFGKLQNLQTVSIDHNDLSGQIVSTLCNNTNLFYLDLSFNQFEGENIFDSVLTNGQNLQYLDISQNNFTGIISPHFLQTHSSLTDLYLSENSFTGSLPPEVGKLIHLGDLDVSQNQLTGGIPISLADCTNWRIFICNPIFSKEQFHQIWLLGSVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDF2</accession>
    <name>A0A068VDF2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00004766001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739363">
        <property type="protein sequence ID" value="CDP18751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDF2"/>
    <dbReference type="FunCoup" id="A0A068VDF2">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDF2"/>
    <dbReference type="Gramene" id="CDP18751">
        <property type="protein sequence ID" value="CDP18751"/>
        <property type="gene ID" value="GSCOC_T00004766001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDF2"/>
    <dbReference type="OMA" id="DESEVMN"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDF2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080092">
        <property type="term" value="P:regulation of pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000067">
        <property type="entry name" value="calcium-dependent protein kinase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000050">
        <property type="entry name" value="Calcium-dependent protein kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="66"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP18751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="540" mass="61248" checksum="76191001F8C804D1" modified="2014-10-01" version="1">MGGCMSIPTNTSFLKRTKNQKQVHESCDQGHSVNGGNAAGLPLSQRISRPVTVLKDPDGHEIYQRYKFGKELGRGEFGVTYQCIDKETGENVACKKISKSKLRTEIDVEDVRREVEIMRHLPKNPNIVSYIAAYEDKEAIYLVMELCEGGELFDRIVARGHYTERAAALVTKSILEVVKLCHKHGVIHRDLKPENFLFANTSENSPLKAIDFGLSIFFQPGQHFCEIVGSPYYMAPEVLRRNYGSEVDVWSAGVILYILLCGVPPFWAESEEGIAHAIVRGEIDFRRDPWPKISRNAKDLVKGMLEPNPYTRLTVEEVLENEWIKNANQVANIPLGEGVRTRIKQFSLMNKFKKRVLRVVADYLPDDEVHGIKQMFYSMDTDQNGSLSFEELKDGLNKFGQDVADPDVELLIDAADLDGNGMLNCDEFVTLAVHLKRLSSDEHLLQAFHQFDKNGNGYIEFEELRDSLSDEHLGPNNDQFVQDIIFDADLDKDGKISYAEFKAMMTTGADWKMASRQYSRAMLNVLSMKLFKDKSMQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDP6</accession>
    <name>A0A068VDP6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00013408001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739381">
        <property type="protein sequence ID" value="CDP18866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDP6"/>
    <dbReference type="FunCoup" id="A0A068VDP6">
        <property type="interactions" value="3497"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDP6"/>
    <dbReference type="Gramene" id="CDP18866">
        <property type="protein sequence ID" value="CDP18866"/>
        <property type="gene ID" value="GSCOC_T00013408001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDP6"/>
    <dbReference type="OMA" id="MMKQQEP"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDP6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000140">
        <property type="entry name" value="SMU1, DNA replication regulator and spliceosomal factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP18866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="514" mass="58071" checksum="6596A5E9B6C8FC18" modified="2014-10-01" version="1">MASTLEIEARDVIKIVLQFCKENSLHQTFQTLQNECQVSLNTVDSLETFVADINGGRWDAVLPQVSQLKLPRKILEDLYEQIVLEMIELREMDTARAILRQTQVMGVMKQEQPERYLRLEHLLVRTYFDPHEAYQDSTKEKRRAQIAQALSVEVSVVPPSRLMALIGQALKWQQHQGLLPPGTQFDLFRGTAAMKQDVDDMYPTTVGHTIKFGKKSHPECARFSPDGQFLVSCSVDGFIEVWDHISGKLKKDLQYQADETFMMHDDAVLCLDFSRDSEMLASGSQDGKIKVWRIRTGQCLRRLERAHSQGVTSIVFSRDGTQLLSTSFDSTARIHGLKSGKMLKEFRGHTSYVNDAIYTNDGSRIITASSDCTVKVWDVKTADCLQTFKPPPPLRGGDASINSVHLFPKNADHIVVCNKTSSIYIMTLQGQVVKSFSSGKREGGDFVAACVSPKGEWIYCVGEDKNLYCFSYQSGNLEHLMKVHEKDVIGITHHPHRNLVATYSEDCTMKLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE85</accession>
    <name>A0A068VE85_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00001349001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739280">
        <property type="protein sequence ID" value="CDP18008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE85"/>
    <dbReference type="Gramene" id="CDP18008">
        <property type="protein sequence ID" value="CDP18008"/>
        <property type="gene ID" value="GSCOC_T00001349001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE85"/>
    <dbReference type="OMA" id="CHIHYAT"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VE85"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000002">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF236">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP18008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="303" mass="34072" checksum="959635C399ABAE5C" modified="2014-10-01" version="1">MQLKTKYIHKASTIYIMDCHIHYATHTHTLYVSFSYVFILFYFICLSTLIFLFVVVYYSLYRIIGHFLNIFLAGNFTSLCLFASPVFTFARIIKMKSVEEFHPYPYLAGALNCFFWVFYGSPMVHPNSILLVITNSIGFVLELAYLAMFFHFSHSKKQRLIVVFGLIGGAVFAAGIALITLLVFHNTDRRSLFVGAICVAFSIILSASPLSIMKQVIKTKSVEFMPFWICLAGFCNGTVWAVYALLPLDPFILTGNGVGALLGFVQLCLHIKYRRTTPKGGSNDMPGKPSELQLPVSQNQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEC4</accession>
    <name>A0A068VEC4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00007408001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739388">
        <property type="protein sequence ID" value="CDP18904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEC4"/>
    <dbReference type="FunCoup" id="A0A068VEC4">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEC4"/>
    <dbReference type="Gramene" id="CDP18904">
        <property type="protein sequence ID" value="CDP18904"/>
        <property type="gene ID" value="GSCOC_T00007408001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEC4"/>
    <dbReference type="OMA" id="PRDNDVH"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080028">
        <property type="term" value="P:nitrile biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000108">
        <property type="entry name" value="Kelch repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000102">
        <property type="entry name" value="Nitrile-specifier protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP18904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="329" mass="35714" checksum="DE885F3EED43DD2D" modified="2014-10-01" version="1">MSFMQGKWFKLDQKGAGPGARSSHAISIVGDKVYAFGGEFTPRIPVDNALYVFDLVERTWSVAEATGDIPPPRVGVSMTSIGDIIYVFAGRDATHKELNELYSFDTSSNRWTLLTSGDTGPENRSYHSIAADGRCLYVFGGCGVSGRLNDLWAYDVIDGKWTKFPAAGENCKPRGGPGLAVSLGKIWVVYGFSGVEIDDVHYFDLVEEKWIQVETTGEKPTPRSVFSTLGIGKYIFISGGEIDPSDLGHLGAGKFAAEVYALDTETLAWKKVEDGSNSVEHPGPRGWCAFAGGKLDGQEGLLVYGGNSPSNDRLEDIYFFCPSLFENGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF12</accession>
    <name>A0A068VF12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">U-box domain-containing protein</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase PUB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00011999001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF12"/>
    <dbReference type="STRING" id="49390.A0A068VF12"/>
    <dbReference type="Gramene" id="CDP18273">
        <property type="protein sequence ID" value="CDP18273"/>
        <property type="gene ID" value="GSCOC_T00011999001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF12"/>
    <dbReference type="OMA" id="KSNRNCL"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF12"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000442">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058678">
        <property type="entry name" value="ARM_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045185">
        <property type="entry name" value="PUB22/23/24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22849:SF163">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22849">
        <property type="entry name" value="WDSAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25598">
        <property type="entry name" value="ARM_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="436" mass="47572" checksum="B1204A6C7F4A54E0" modified="2014-10-01" version="1">MVGDKTTTTTAIGRSTNAAFKRDELYLNLTVPNLFRCPISMDVMKSPVSLCTGVTYDRTSIQAWLSQGHNTCPATMQVLPSTDFTPNLTLRRLIHLYVHHTTSSPPELSPNSSLSSSLRNSLISQSEALELIKNLSSGDTASSATKLVEFVRFSEENRRFVANSAFGVSNLVEILRTSEETQVSDQILLVLEIISPENGVKELLNEKILKSDFDYLSKFFWFFRKGSLSSRIASAKILESIASDADSQRKIAEKQGLLFELYKLSNEETDSSAVEASLSALIAVSTSKTAKKELVRFGIVKTVGEILSGSEAARPVIEKAAEVLASVATCTDGRAAISEDEGCIMGVVKRLMKCSGVATEHGIVVLWSLCCLARDRTAQEAVLKVNGVTKVLLVMQSDCSAGVRKMCGDLVKVLRVKNSKSCLASYETRTTHIMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF56</accession>
    <name>A0A068VF56_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH three-helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012651001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739461">
        <property type="protein sequence ID" value="CDP19202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF56"/>
    <dbReference type="STRING" id="49390.A0A068VF56"/>
    <dbReference type="Gramene" id="CDP19202">
        <property type="protein sequence ID" value="CDP19202"/>
        <property type="gene ID" value="GSCOC_T00012651001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF56"/>
    <dbReference type="OMA" id="CHGCASE"/>
    <dbReference type="OrthoDB" id="515857at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF56"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057523">
        <property type="entry name" value="HTH_74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34799">
        <property type="entry name" value="OS07G0656300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34799:SF2">
        <property type="entry name" value="OS07G0656300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25370">
        <property type="entry name" value="HTH_74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH three-helical bundle" evidence="2">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="206" mass="22397" checksum="F6044279D4362BF7" modified="2014-10-01" version="1">MKKNKLRFKLSKSQRSHWTCSSSSTVTTSENDDRRVKVIAVVSKFHDTMKLKVVRKRRSKNLSISDCQKRTSSRKQASKVESSASVSASASSCLSSGSSSVISSAGSSGNVMMKMRGGGRGFVTPPAKDPKRKPILGSTHMRRRAEAILKVLSSHGRASEVKIRELLGDSPSTSKALRILLNLEQVKRSGAGGRTDPYVYMVNIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHP3</accession>
    <name>A0A068VHP3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00011267001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the polygalacturonase-inhibiting protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740005">
        <property type="protein sequence ID" value="CDP20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHP3"/>
    <dbReference type="FunCoup" id="A0A068VHP3">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VHP3"/>
    <dbReference type="Gramene" id="CDP20127">
        <property type="protein sequence ID" value="CDP20127"/>
        <property type="gene ID" value="GSCOC_T00011267001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHP3"/>
    <dbReference type="OMA" id="DPFPEMN"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF19">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658663" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="481" mass="52858" checksum="DB13368652CAF5F1" modified="2014-10-01" version="1">MQSLFFSHLLCAFLLLFTLLNLRYLTAEAAKCHPDDEAGLLAFKSGITADPSGMLQSWKPGTDCCSWNGITCLQGTRVTALDLSGQPQNSTQVLSGTISPSLSKLQFLDGVYFLNLRKLSGPFPNFLFSLPRLIFIYIENNRLSGPIPENVGSLAKLQAFSLQGNRFSGHIPTSISQLTQLSQLRLGGNLLTGTIPLGIQNLKNLTSLTLDGNQLTGTIPDIFASFPTLYNLNLANNKLTGNIPTSILSLAPNLRYLELGHNSLSGQIPDFLGKFRALDTLDLSWNQFSGLVPKTFSNLTKIFNLDLSHNYLVDPFPAMQVKGIESLDLSYNQFHLVNIPAWVTSSPIIYSLKLAKCGINLKLDDWNPAQTYFYDYIDLSENQITGSPFKLLNRTEYLKGFYASGNKLNFKLETLKLPKTLKDLDLSRNLISGKVPNAVAGLQKLNVSHNHLCGQLPKTRFPASAFSGNDCLCGSPLPACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHY5</accession>
    <name>A0A068VHY5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_1108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00013480001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740192">
        <property type="protein sequence ID" value="CDP20331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHY5"/>
    <dbReference type="STRING" id="49390.A0A068VHY5"/>
    <dbReference type="Gramene" id="CDP20331">
        <property type="protein sequence ID" value="CDP20331"/>
        <property type="gene ID" value="GSCOC_T00013480001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHY5"/>
    <dbReference type="OMA" id="GLYHSHY"/>
    <dbReference type="PhylomeDB" id="A0A068VHY5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07821">
        <property type="entry name" value="PYR_PYL_RCAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF138">
        <property type="entry name" value="ABSCISIC ACID RECEPTOR PYL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="19226" checksum="9AFEEC0BCBDCB1A8" modified="2014-10-01" version="1">MAFQLPTTVSSHHNPVLQPNECSSTLFQTIAAPASVVWALVSDFENPQRYKPFVRSCKIIDGQANQVGCLRRVDVASGLPASYSIERLETLDHDQCIFGFSIVSGDHRLSNYRSIMSLHPNGGDETVVVETYVIDAAEANTKEETCAFVDTIVKLNLRTLSRVAEDLAGKAQQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIK4</accession>
    <name>A0A068VIK4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DH200=94 genomic scaffold, scaffold_1177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00003012001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Probably active at the 3' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740261">
        <property type="protein sequence ID" value="CDP20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIK4"/>
    <dbReference type="STRING" id="49390.A0A068VIK4"/>
    <dbReference type="Gramene" id="CDP20409">
        <property type="protein sequence ID" value="CDP20409"/>
        <property type="gene ID" value="GSCOC_T00003012001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIK4"/>
    <dbReference type="OMA" id="GRYHNDR"/>
    <dbReference type="PhylomeDB" id="A0A068VIK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="209" mass="24144" checksum="8F2E2CBD6180CB9E" modified="2014-10-01" version="1">MYQRPDMITPGVDPQGQPIKPHKIQEHFKDFYEDIFEELGKFDKIESLNICDNLADHMISNVYVQFKEEDQAAAALQALQGHFYSGCTIIADFSPVTDFREATYRRSSRGGYCNFMHIKMIGRDLRRKLFGSHILKYRRSRRGAEETGTPGMRATAAEGGDRHARHESDSSGGRRRHAASPRRSKSPVREGSEERRARIEQWNRQRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIP4</accession>
    <name>A0A068VIP4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00011427001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="HG740353">
        <property type="protein sequence ID" value="CDP20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIP4"/>
    <dbReference type="STRING" id="49390.A0A068VIP4"/>
    <dbReference type="Gramene" id="CDP20487">
        <property type="protein sequence ID" value="CDP20487"/>
        <property type="gene ID" value="GSCOC_T00011427001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIP4"/>
    <dbReference type="OMA" id="TRCDEVT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIP4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="145"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="345"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="559" mass="61279" checksum="D22665B6D7E69B5E" modified="2014-10-01" version="1">MSYVPPHLRNSNTDTAATAATTVTTLDTNHFHSYSNPSSETNNSSNNYLNSARRSTVNYTSPRTVSAPDIVFPNWKPSERVLRLTPEQIDEVRLRLNLDVIVAPDSPPAPAPIESFTDMCLHSSIMKDISFHGYTTPTPIQSQAMPVALSGRDLLGCAETGSGKTAAFSIPMIQHCLAQPPVRRGDGPLALVLAPTRELAQQIEKEVKAFSKSLDSFRTAIVVGGTNIGDQRSELRLGVDVVVATPGRFIDHLQQGNTSLSRISFIVLDEADRMLDMGFEPQMREVMQNLPQKHQTLLFSATMPVEIEMLAQEYLTNPVQVKVGKVSCPTANVLQSLEKVPENEKIDRLLGMLVEEAARAERFGHPFPLTIVFVERKTRCDEVAEALIAQGLKAVVLHGGRSQSERELSLHDFRHSTTNILVATDVASRGLDVSGVAHVVNLDLPKTMEDYVHRIGRTGRAGSSGRATSFYTDRDMYLVAQIKKAIVDVESGNTVSYATGKVARRMEKEAAAAHKEARIALSKVSLLGTAPLNVEDKYKHMIFPAMARKEGAADDAWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ50</accession>
    <name>A0A068VJ50_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Lipoxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00013092001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG740519">
        <property type="protein sequence ID" value="CDP20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ50"/>
    <dbReference type="STRING" id="49390.A0A068VJ50"/>
    <dbReference type="Gramene" id="CDP20619">
        <property type="protein sequence ID" value="CDP20619"/>
        <property type="gene ID" value="GSCOC_T00013092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ50"/>
    <dbReference type="OMA" id="VYAMEMS"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01751">
        <property type="entry name" value="PLAT_LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.375.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.375.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.372.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001246">
        <property type="entry name" value="LipOase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042057">
        <property type="entry name" value="Lipoxy_PLAT/LH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027433">
        <property type="entry name" value="Lipoxygenase_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00468">
        <property type="entry name" value="PLTLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
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    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="13">
        <location>
            <begin position="133"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <name>A0A068VJL1_COFCA</name>
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        <submittedName>
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="246" mass="26663" checksum="4C76B05997E38E39" modified="2014-10-01" version="1">MAPPNRPPTPPPPPSSSSSSSSHDLGHEEEDSSSIASSASDFSDIYTASTIQPPQNPNPTTPNSTINTTTASAAQSLPPPTLLHLSFNQDHGCFATGPTSGFRIYNCDPFREIFRRDFFSSSSSTASAVVGGGIGIVQMLFRCNILALVGGGPDPQYPLNKVMIWDDHQARFFIGELSFRSQVKSVRLRRDRIVVVLLQKIFVYNFADLNKLAVGLNKLAFFFLSDFLSSFPSAIHLLNKLAVALG</sequence>
</entry>
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    <name>A0A068VJM7_COFCA</name>
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        <lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="De Bellis F."/>
                <person name="Dussert S."/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
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            <end position="262"/>
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            <end position="80"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="353" mass="38825" checksum="424EFCE6B2646190" modified="2014-10-01" version="1">MEPKFTGKPITAHNAVDLDQMPDTPNRGAHHRRAQSETFFRFPDLDDDILLDDVVVFDHPPGPSLSSDATLLQPNNNESGRAQAQAQAQAQPARLIEKSHFRSLSVDADFFEGLNFGASSSSSADGGGGGGSAAAGSGAPWGPRHRHSSSMDGSSSFASAMTTSFEAMMADSDKKTAGADRLQELALIDPKRAKRILANRQSAARSKERKIRYTSELERKVQTLQTEATTLSAQVTMLQRDTTGLTAENKELKLRLQAMEQQAHLRDALNDTLREEVQRLKIAASQIPTANGNNFNRGMRPQYSSQAQTFHHFGNHQAEQHQQQQQHHMPQSTMNPGFSTQPKPSFLDFNHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKP3</accession>
    <name>A0A068VKP3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_1012</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00005630001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740096">
        <property type="protein sequence ID" value="CDP20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKP3"/>
    <dbReference type="STRING" id="49390.A0A068VKP3"/>
    <dbReference type="Gramene" id="CDP20223">
        <property type="protein sequence ID" value="CDP20223"/>
        <property type="gene ID" value="GSCOC_T00005630001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKP3"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="109" mass="12235" checksum="B48A8020748526AD" modified="2014-10-01" version="1">MIICVAQRYWKVKFGDKSKESRKAAGQAWEDPTLADWPENDSGLFCGDLGNEVNDDVLSKAFSRFPSFNMARVSYLNSSTFYMSQPSLVRIIETLICLLVVVAFGEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKP7</accession>
    <name>A0A068VKP7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">myrcene synthase</fullName>
            <ecNumber evidence="5">4.2.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00006774001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-geranyl diphosphate = beta-myrcene + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16965"/>
            <dbReference type="ChEBI" id="CHEBI:17221"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="EC" id="4.2.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16966"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.15" evidence="5"/>
    <dbReference type="EMBL" id="HG740098">
        <property type="protein sequence ID" value="CDP20228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKP7"/>
    <dbReference type="Gramene" id="CDP20228">
        <property type="protein sequence ID" value="CDP20228"/>
        <property type="gene ID" value="GSCOC_T00006774001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKP7"/>
    <dbReference type="OMA" id="IAYHFND"/>
    <dbReference type="OrthoDB" id="1936865at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050551">
        <property type="term" value="F:myrcene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00684">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000007">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.130:FF:000001">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044814">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF137">
        <property type="entry name" value="TERPENE SYNTHASE 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="7">
        <location>
            <begin position="184"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="480" mass="55347" checksum="7D77510354643E9C" modified="2014-10-01" version="1">MNLIDTLQRLGLAYHFEDDMNAILSQLSSSGQSDGDLLTTALRFRLLRHNGHKISSDIFQKFMDKNGKFKDSLKEDTMGLLSLYEASHLAANGEDILLEAMELTEAHLKQSLPSLPTQLARKVSSALELPRHRRMARLEARRYIQEYSEEIGHDPNLLELAKLDYNKVQSLHQMELTDISRWWKQLGLVDKLTFARDRPLECFLWTVGILPEPKYSNCRIELAKTIAILLVIDDIFDTHGTIDELVLFTNAIRRWDLEAMEGLPEYMRICYMALYNTTNEICYKILKENGWSVLPYLKATWIDMIEGFMLEASWYSNGQEPNMEEYVANGVTTAGTYMAMVHLFFLIGQGVTEENVKLLMKPYPKLFSCSGRILRLWDDLGTAKEEQERGDLASSIQLFMRENNITCDEEGRKRILQLIDNLWKDLNWGLVSRNAMPLAIIKAAFNMARSSQVVYQHEEESYFSSVDNYVESLFFTPIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKV9</accession>
    <name>A0A068VKV9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00010588001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741866">
        <property type="protein sequence ID" value="CDP21204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKV9"/>
    <dbReference type="STRING" id="49390.A0A068VKV9"/>
    <dbReference type="Gramene" id="CDP21204">
        <property type="protein sequence ID" value="CDP21204"/>
        <property type="gene ID" value="GSCOC_T00010588001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKV9"/>
    <dbReference type="OMA" id="DPEICEP"/>
    <dbReference type="PhylomeDB" id="A0A068VKV9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053098">
        <property type="entry name" value="Petuviruses_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435:SF1">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="333" mass="38334" checksum="5C0051AB8E192001" modified="2014-10-01" version="1">MSLADPHLLEALKVQVQIIGAKQVSDAIAATLHYQMVYRVQNHAQDLAIPGGENALLIRVDEKNGTSCTHVPRQILKQELIQLLPNDWITDYEDQDIIQYFDKEGLPVSWFQDPISGHVYFDVCNVCEKCQLENTLDFELPDLSRRKKSRPQQIEPRPCKLYLDPQDPDTDTFVSQRSRFNGYQILSDWVSKSSKDPLPPSKKDFHPYYQKCLDILEKEAKQLKQEWKKSFCNPEPLIPVHIPQVQECFKFSEADFPKLETFNKNGSRHTPKIQNISSTILPSGETVQPNPSEDVLNWQTENSLVQNIALTSIHRNVSEVKGKIEQIDLKIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKY0</accession>
    <name>A0A068VKY0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_2892</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00000811001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG741976">
        <property type="protein sequence ID" value="CDP21229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKY0"/>
    <dbReference type="STRING" id="49390.A0A068VKY0"/>
    <dbReference type="Gramene" id="CDP21229">
        <property type="protein sequence ID" value="CDP21229"/>
        <property type="gene ID" value="GSCOC_T00000811001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKY0"/>
    <dbReference type="OMA" id="FTTHERN"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKY0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF1">
        <property type="entry name" value="CYTOCHROME P450 82E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="38001" checksum="E8DE1676ABBB651E" modified="2014-10-01" version="1">MDLIQYLVAIPVVLALFLSYIQWKPRSQITDEKRKSPPEPEGAWPVIGHLLQMNPKIHVAETLAAMADKNGPVFTIRLGMLPVLVVNNWESVKECFTTNDKAFASRPPSSFAKYLCYDYAAFGIAPYGRYWRDVRKMALRELLSAQRLEKLNQVRISEVKTSIKEIFLNISEVNNHSNEIKAPARVDLRDVFEKLTLNIVLRKIAGGKHTDSDVGIKRDAEFRRVLMEFEAFARVLVVSDIIPFRFLKWLDPQGHIKSMKRLAKELDKYMQTWVDEHKEGRMKNSDDGDDELDFIDVLLSTIKDESICGFSKEVVIKSTILVSHPCTCIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLE9</accession>
    <name>A0A068VLE9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_1294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00011100001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740378">
        <property type="protein sequence ID" value="CDP20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLE9"/>
    <dbReference type="FunCoup" id="A0A068VLE9">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP20503">
        <property type="protein sequence ID" value="CDP20503"/>
        <property type="gene ID" value="GSCOC_T00011100001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLE9"/>
    <dbReference type="OMA" id="RDIMEIV"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLE9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000001">
        <property type="entry name" value="Protein SRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="360" mass="40935" checksum="7747483BC04F0F31" modified="2014-10-01" version="1">MESSMIKLGGSLKVPYVQELAKEKFASVPPRYIRPDPTKLHGVSTEEIPVIDMQRLLSDESVNPELEKLHFACKEWGFFQLINHGVSSSLVDKLKLEMQKFFNLRIEEKMRFAQEPGDVEGYGQAFVVSEEQKLDWGDMFYMVALPTHLRKPHLLPKLPLPFRETLDQYSRELKILAIKVLEQMTKALGMKLEDMTMLFQEGMQSMRMNYYPPCPQPELVMGLCPHSDAVGLTILLQVNEVEGLQIKKAGAWVPVVPLPYAFIVNVGDILEIVTNGIYKSVEHRATVNLHSERLSIATFLVPKLGGDMGPAPSLITPENPAIFRRISMIDYLKAFFSRELDGKSFVHAMRTQIEDFWAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLY1</accession>
    <name>A0A068VLY1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">COBRA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00013320001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COBRA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG744768">
        <property type="protein sequence ID" value="CDP21681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLY1"/>
    <dbReference type="FunCoup" id="A0A068VLY1">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLY1"/>
    <dbReference type="Gramene" id="CDP21681">
        <property type="protein sequence ID" value="CDP21681"/>
        <property type="gene ID" value="GSCOC_T00013320001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLY1"/>
    <dbReference type="OMA" id="CQNNGSH"/>
    <dbReference type="OrthoDB" id="2012261at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010215">
        <property type="term" value="P:cellulose microfibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052324">
        <property type="term" value="P:plant-type cell wall cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056900">
        <property type="entry name" value="COB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006918">
        <property type="entry name" value="COBRA_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673">
        <property type="entry name" value="PROTEIN COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673:SF61">
        <property type="entry name" value="PROTEIN COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25079">
        <property type="entry name" value="COB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04833">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038122">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656075" description="COBRA-like protein" evidence="9">
        <location>
            <begin position="34"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="COBRA C-terminal" evidence="10">
        <location>
            <begin position="229"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="454" mass="50674" checksum="9E9B5D43D8E47277" modified="2014-10-01" version="1">MDSSCFRSLSKFTACAIVVLLSLSCFSFTTTEAYDALDPNGNITIKWDVITWTPDGYVAVVTMFNFQQYRHIQAPGWTLGWTWAKKEVIWSMVGAQTTEQGDCSRFKLNTPHCCKKDPTVVDLLPGTPYNQQIANCCKGGVINSWVQDPATAVSAFQVSVGSSGTTNRTVRMPKNFTLKAPGPGYTCGPAKVGKPTKFSTADGRRTTQAMMTWNVTCTYSQFLAQKTPSCCVSLSSFYNDTIVPCPTCTCGCQNNGSHPGSCVDADAPHLASVVSDHGKSNNLAPLIQCTSHMCPIRVHWHVKVNYKEYWRVKVTITNFNYRMNYSQWNLVVQHPNFDNLTQIFSFNFKPLTPYQAINDTAMLFGIKFYNDFLMEAGPYGNVQSELLFRKDKSTFTFDKGWAFPRRIYFNGDNCVMPPPDSYPYLPNGGSRRDISIVVLVTALLSSIAFFFTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN13</accession>
    <name>A0A068VN13_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00001486001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741522">
        <property type="protein sequence ID" value="CDP21073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN13"/>
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    <dbReference type="Gramene" id="CDP21073">
        <property type="protein sequence ID" value="CDP21073"/>
        <property type="gene ID" value="GSCOC_T00001486001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN13"/>
    <dbReference type="OrthoDB" id="1923451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN13"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051564">
        <property type="entry name" value="LRR_receptor-like_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055:SF36">
        <property type="entry name" value="PROTEIN KINASE, PLANT-TYPE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="76" mass="8535" checksum="D55BE8E0A4F711BC" modified="2014-10-01" version="1">MVHCDLKPSNILLDQDMVAHVCDFRIVYLLGNGESNKFSILMTQYGPEGLVSTSCDIYVGYFQNLISCKMGARLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQP9</accession>
    <name>A0A068VQP9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_9459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00009810001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748543">
        <property type="protein sequence ID" value="CDP22048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQP9"/>
    <dbReference type="Gramene" id="CDP22048">
        <property type="protein sequence ID" value="CDP22048"/>
        <property type="gene ID" value="GSCOC_T00009810001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQP9"/>
    <dbReference type="OrthoDB" id="1540731at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP22048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="92" mass="10040" checksum="4257AF2AE7FAB485" modified="2014-10-01" version="1">MALRPEFEQLRGSLLHRSPLPTVDAALAELITEETRLDSQVPASLGSMDSVLAAAKAERSSTITKVKWHGSAGNRYSPPSAHYRYSTRLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM66</accession>
    <name>A0A068TM66_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00014245001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM66"/>
    <dbReference type="FunCoup" id="A0A068TM66">
        <property type="interactions" value="2670"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TM66"/>
    <dbReference type="Gramene" id="CDO97029">
        <property type="protein sequence ID" value="CDO97029"/>
        <property type="gene ID" value="GSCOC_T00014245001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM66"/>
    <dbReference type="OMA" id="FEQSTYD"/>
    <dbReference type="OrthoDB" id="3171at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO97029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="7767" checksum="50A38E8F89B0B9C4" modified="2014-10-01" version="1">MVLFDKATYDKLLSEAPKYKLITPSVLSDRLRISGSLARKAIRELMARGLIRMVSAHASQQIYTRATNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPQ7</accession>
    <name>A0A068TPQ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Homeobox-leucine zipper protein GLABRA 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00021990001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HD-ZIP homeobox family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPQ7"/>
    <dbReference type="FunCoup" id="A0A068TPQ7">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPQ7"/>
    <dbReference type="Gramene" id="CDO98022">
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        <property type="gene ID" value="GSCOC_T00021990001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPQ7"/>
    <dbReference type="OMA" id="SYHTWTK"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08875">
        <property type="entry name" value="START_ArGLABRA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000026">
        <property type="entry name" value="Homeobox-leucine zipper protein GLABRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000229">
        <property type="entry name" value="Homeobox-leucine zipper protein HDG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042160">
        <property type="entry name" value="HD-Zip_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057993">
        <property type="entry name" value="HD-Zip_IV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654:SF24">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN GLABRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN MERISTEM L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25797">
        <property type="entry name" value="PDF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="14">
        <location>
            <begin position="272"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="110"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO98022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84415" checksum="1D468969F42A8606" modified="2014-10-01" version="1">MGVLDMSNPPPTSQTKDFFPSPALSLSLAGIFRRGAAAANLEVEEGDEGSGGGGAAAASAGGGGRREETVEISSENSGPLRSRSDDMDDYEGEGEQDDGGEDDQNNKKKKRKKYHRHTAEQIREMEALFKESPHPDEKQRQQLSKQLGLHPRQVKFWFQNRRTQIKAIQERHENGLLKTELEKLRDENKALRETIKKASCPSCGFATSAKGPSTASDEQQLRIENARLKAEVEKLRAALGRYTPGTSPSDSSCSAGNEFENRSCLEFYSGIFGLKKSRIMEIVNQALEELKQMATLGQPLWIRSLESGREILNYDEYMKKFPFENAKNAGPKRPIEASRETGIVFVELPPLVQCFMDVNQWKEMFPGRVSKAATVDVVCTGEGANRDGLVQLMFAELQMLTPMVPTREVYFVRYSKQITADQWAIVDVSIDKVEDSVDASLTKCRKRPSGCIIEDKSNGHCKVTWVEHLECQKSTVHSLYRAVVNSGLAFGARHWMTTLQLQCERLAFFMATNVPTKDSSGVATLAGRKSILKLAHRMTVSFCRALGASSYNTWSKITSKSGDDIRVASRKNLNDPGEPLGVILCAVSSVWLPVSHHDLFDFLRDESRRNEWDMMLNGAPAQSIANLAKGQDRGNAVTIQTIKTKDNSMWVLQDSCTNAYESMVVYAPVDISSMQSVMTGCDSSNIAVLPSGFSILLDGVESRPLVITSRLEEKSSEGGSLLTIAFQILTSNSPTAKPSVESLESVNTLISCTLQKIKASLNCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQK1</accession>
    <name>A0A068TQK1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022676001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQK1"/>
    <dbReference type="Gramene" id="CDO98541">
        <property type="protein sequence ID" value="CDO98541"/>
        <property type="gene ID" value="GSCOC_T00022676001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQK1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="56" mass="6705" checksum="4E29D2561B6F6E11" modified="2014-10-01" version="1">MKFSSSSLFWDGKKWWDDMNDNVECMRDLTDFPARYLKGRRNLTRRSCSPVVDGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQZ2</accession>
    <name>A0A068TQZ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00025597001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQZ2"/>
    <dbReference type="STRING" id="49390.A0A068TQZ2"/>
    <dbReference type="Gramene" id="CDO98700">
        <property type="protein sequence ID" value="CDO98700"/>
        <property type="gene ID" value="GSCOC_T00025597001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQZ2"/>
    <dbReference type="OMA" id="PQNGAFM"/>
    <dbReference type="PhylomeDB" id="A0A068TQZ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000035">
        <property type="entry name" value="Putative receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052232">
        <property type="entry name" value="RLK_Ser/Thr-Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984">
        <property type="entry name" value="OS01G0323000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984:SF26">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="222"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDO98700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="522" mass="58536" checksum="32DD8403664B751F" modified="2014-10-01" version="1">MCIGSFFNVIFFGQSLPLFYVRTLWLLKIVQATIFLCFHLFKMASGLNFELSKRTHIFHLKVWVLIAMLVGLFLVFIVLVLPFCLSRKRSKRGSATLPISQIPKVSKEIKEIKVDQYSAKNYAAHDIDFLTLQDKFSDKDSDKLLSCEKAMNADNSSQYDSFTNLEKEGVACESGEKGGAGAIYNSHPVAVSSPLSGLPEFSHLGWGHWFTLRDLEVATNRFSKENVIGEGGYGVVYRGRLINGSPVAVKKILNNIGQAEKEFRVEVEAIGHAHYCLNLLLVYEYVNNGNLEQWLHGAMSHRGYLTWEARMKVLVGTAKALAYLHEAIEPKVVHRDIKSSNILIDDDFNAKLSDFGLAKLLGAGKSHITTRVMGTFGYVAPEYANSGLLNEKSDVYSFGVVLLEAITGRDPVDYGRPAPEVNLVDWLKVMVGSRRFEEVVDPTIETRPPTTALKRALLTALRCVDPDAEKRPIMSQVARMLESEEYPVLRKGGRRRRNQPGSQRENDETDRSENPILRRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR22</accession>
    <name>A0A068TR22_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00022600001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the early nodulin-like (ENODL) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR22"/>
    <dbReference type="FunCoup" id="A0A068TR22">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TR22"/>
    <dbReference type="Gramene" id="CDO98487">
        <property type="protein sequence ID" value="CDO98487"/>
        <property type="gene ID" value="GSCOC_T00022600001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR22"/>
    <dbReference type="OMA" id="MIVKVME"/>
    <dbReference type="OrthoDB" id="959565at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11019">
        <property type="entry name" value="OsENODL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000010">
        <property type="entry name" value="Early nodulin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041846">
        <property type="entry name" value="ENL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF289">
        <property type="entry name" value="EARLY NODULIN-LIKE PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654184" description="Phytocyanin domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="12">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO98487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="19504" checksum="7B2A69AAEE0419DE" modified="2014-10-01" version="1">MASFFQSFSTCFLLVFIFTSLHFLTGISVEFDVGGNTGWVIPPSKNDDLYNDWASKNRFKVNDTLIFTYKKDSVMEVTKEEYEKCRSLHPMFFSNNGNTIYTLDRSGLFYFISGVSGHCERGLKMVIKVLDVESSPQSANQTANTSSPAKSAAATYFGTSMMMVILAVFGVIIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR44</accession>
    <name>A0A068TR44_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L34Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022515001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDO98429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068TR44"/>
    <dbReference type="Gramene" id="CDO98429">
        <property type="protein sequence ID" value="CDO98429"/>
        <property type="gene ID" value="GSCOC_T00022515001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR44"/>
    <dbReference type="OMA" id="LGRTHKC"/>
    <dbReference type="OrthoDB" id="1909644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR44"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012870">
        <property type="entry name" value="DUF1666"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46702:SF2">
        <property type="entry name" value="DNA LIGASE (DUF1666)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46702">
        <property type="entry name" value="DNA LIGASE (DUF1666)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07891">
        <property type="entry name" value="DUF1666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="68605" checksum="4132B4060316B87B" modified="2014-10-01" version="1">MQCPGETIAGLFYNASSSFLLLFIFFYVTSILLAKLFRFLGGNLFFSRNQNEFEYGEFSDEEVEQENGHFHADSMQQSGPLETNILDGGETLIFMQENSDHEDPIRVPGEEIVNPDEEAFSQECNEASYNSEELSVYSSAALESVHSDEAVGEEEIPPARDTDSSYAYQTNKNDPTSRRTLNQMKSGLIMDNKNNKAKCEEGIAKDEEKDATFTRDENFLVFAPSKRESKKLLQPEGKDEEDIFGDSCTVGSTSKSSSEWRSSNINYRDSGTDDPFSSSSRRSCPKWESYTVFQKYDEEMLFLDRISAQKLHETESLKSIQACPRSISDRIVYKLAAKNKSSSDFRRNPYHELEGTYVAQICWTWEALNWNYKYFQRLRAARREQDPGCPAYVAQQFQQFLVLLQRYVENEPYEHGKRPEIYARMRSLAPKLLQVPEYRDSEEEKKDEGSGARISSDSFLIIMEESIRTFMNFLKADKESRCQVLAAFFRRNRRGSADATLLLLLKKVNKKKKMKLKELRRSGKCLRRRRLRLEEEMEILMAFIDLKVVSRVLRMREVHEEQLHWCENKMSKVRVSDGKLQRDSSPLFFPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT99</accession>
    <name>A0A068TT99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00026322001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="CDO99242">
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    </dbReference>
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    <dbReference type="OMA" id="SMLGFWK"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TT99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23129">
        <property type="entry name" value="RING-HC_XBAT35-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF45">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE XBAT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO99242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="491" mass="53073" checksum="FCFBEEDFE3B0E058" modified="2014-10-01" version="1">MGQQQSKDELLYQQVSYGNTEGIKALRRDGAGLEWLDKEGKTPLIAACMNPELYNVAKTLVELGANVNAYRPGRHAGTPLHHAAKRGLEQAVKLLLSDGANALVMNDDCQTPLDVARSKGFSNVVRAIESHICLFSGSMRELYGPGFLELLAPQLLSRKVWVVVLPCGSRSLKKPFKLELAIYSNAQDAQPRTIVALWKANMEEPNFSQSDPTVIITDNGTIPRRWRRRRGITYSQVARRTRVKLAAANERDRQQLQWFCNACKGIPQVVHPAFPFNTQVNVAPATAPPEDVELAMAIDASLQSAMRPHLGPHLVSGADASTSRTNSECITANCGSSISGTAPLQKGEKLGYKDQETGASGVVIHHSQIQSDSLGVRSTVQNSVQASIPSAPPVADSAVDDGPIHYPSIDASPLDFSSPPVERFDAKPEERKDTGASSSCVICLDAPIEGACIPCGHMAGCMSCLSEIKAKKWGCPVCRAKIDQVVRLYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUA0</accession>
    <name>A0A068TUA0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00029570001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUA0"/>
    <dbReference type="Gramene" id="CDO99870">
        <property type="protein sequence ID" value="CDO99870"/>
        <property type="gene ID" value="GSCOC_T00029570001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUA0"/>
    <dbReference type="OMA" id="IRAQHTI"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUA0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053070">
        <property type="entry name" value="RING-type_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47035">
        <property type="entry name" value="OS11G0150450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47035:SF3">
        <property type="entry name" value="OS11G0150450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="258" mass="28942" checksum="043BFCC937F43AC3" modified="2014-10-01" version="1">MMSSGTNLVMTVIGFAVSTMFIVFVCTRLICARIQLNASRRSFARAHRSDLSILERGLHGLEPVIFANFPTKKYGDNFFSSGENNHSKSCAPNELTYILSVFFFPRVNLVLCSGCGVCAVCLADYHKEDTLRILPSCGHFFHAACIDIWLHQHSTCPVCRVSLRELTERKRFMQPLFSSAIRAQHTIQPANLNTHHSSNSHRLSSTPRDGQRMQPSQDGCRHSERAGVEDRQSNPILNDDRQITKKSGNKEMESPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVI0</accession>
    <name>A0A068TVI0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00026489001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVI0"/>
    <dbReference type="Gramene" id="CDO99353">
        <property type="protein sequence ID" value="CDO99353"/>
        <property type="gene ID" value="GSCOC_T00026489001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVI0"/>
    <dbReference type="OMA" id="QYSCSLP"/>
    <dbReference type="OrthoDB" id="1923497at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF12">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 9, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO99353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="424" mass="46414" checksum="2879A68FBE122BD4" modified="2014-10-01" version="1">MVAKPLYGVLSDALYIGRARRIPYVSIGVFLQVLSWGSLALIPVASEALSILLACVLLSNLGASIAEVAKDALVAEYGQKNKMPGLQSYAFMALAAGGILGNLLGGYFLLQTQQPKSMFLSFSVLLAFQLTITLGMKEDSLGLPQTSSHSLVRKSISESIRKQYFDLLVAAREESISRPLIWIVASTATVPILSGSIFCYQTQCLNLDPSVIGMSKVIGQLMLLVMTVSYDRLWKHVPMRKLVGIVQILYASSVLLDLILVTQVNLWWGIPNEAFVFCFSGVAETLAQFKLLPFHVLFASLAPPGCEGSLMSFLASALCLSSIASGFFGVGFASVIGITSNDYTSLPTGIVMQFLAALLPLLWINRVPATHPSAEKESKKGRSRRTRRTRRVGRVGFGSIYSYRREREPDFLRKLPIETNRNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWK3</accession>
    <name>A0A068TWK3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00032239001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWK3"/>
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        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWK3"/>
    <dbReference type="Gramene" id="CDP00334">
        <property type="protein sequence ID" value="CDP00334"/>
        <property type="gene ID" value="GSCOC_T00032239001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWK3"/>
    <dbReference type="OMA" id="MAWAMSI"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWK3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000146">
        <property type="entry name" value="RING/FYVE/PHD zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022143">
        <property type="entry name" value="DUF3675"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033275">
        <property type="entry name" value="MARCH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012:SF175">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12428">
        <property type="entry name" value="DUF3675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP00334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="292" mass="32037" checksum="0333522FDFFAE905" modified="2014-10-01" version="1">MSEILAVHADRFVKPVQEINPYGIVDEKPQREMVGPSTSLAPRPEEEEVVVMMGENENEEAPLIAMAECRICQEEDSLTNLETPCACSGSLKYAHRKCVQHWCNEKGDIICEICHQPYQPGYTASRPNPEETTIDIGGGWQLSGAPLDLHDPRLLAIAEAERQLLEAEYDDYSSTNASGAAFCRSAALILMALLLLRHALTVTDGDGDDDPSAFFSLFLLRAAGFLLPCYIMVWAISILQRRRQRQEAAALAATQFAFVVQSGQSRGLHFAIASTAPLPTPATALTPQQEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWQ2</accession>
    <name>A0A068TWQ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="6">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00032315001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWQ2"/>
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        <property type="interactions" value="2084"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWQ2"/>
    <dbReference type="Gramene" id="CDP00389">
        <property type="protein sequence ID" value="CDP00389"/>
        <property type="gene ID" value="GSCOC_T00032315001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWQ2"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWQ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000012">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0385">Hypusine</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP00389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="17487" checksum="572C00BE69852AEF" modified="2014-10-01" version="1">MSDDEHHFESKADAGASKTYPQQAGTIRKNGYIVIKNRPCKVVEVSTSKTGKHGHAKCHFVGIDIFNGKKLEDIVPSSHNCDVPHVNRTDYQLIDISEDGFVSLLTENGNTKDDLRLPTDENLLTQIKDGFSEGKDLVVSVMCAMGEEQICALKDIGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWW3</accession>
    <name>A0A068TWW3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032384001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP00444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00032384001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWW3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654289" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="94" mass="11598" checksum="4AD9D18E21FAF22D" modified="2014-10-01" version="1">MQLILYLALLFYKLVCELRIEKKRRERLSYERKKRIRALFFPFFSFFFELQKTPLFPLASPLFFLPFRCLAHRPFLLLKLTAESLYRLFLFLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX56</accession>
    <name>A0A068TX56_COFCA</name>
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        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00034317001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00034317001"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177">
        <property type="entry name" value="CASKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177:SF472">
        <property type="entry name" value="PGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="521" mass="60156" checksum="96FBA9A95B579D90" modified="2014-10-01" version="1">MSKIKQSHVRAVRLVKFVCDELHKKEKEEEEEKKKEKEREKEKEMDFEKEEKEKEREKEEEQEKEPEKEPEKEKEQEKEKAKEPEKEQEKGKGKEKEKEKEKEKEMDFVQFFFIPEEEKDMDFVQDFFIPENSTAILHLAVEHGVFELVEQCLKVFPDLIWYADKPRKSVPWRHAHYTSTVKGSLVWNDATQHADTATASSNPPEYTETTSGHWKWHEGQYADTATGTERLLLHVAIEHRRVEIFNYLITYIGKNTKAYADLKIEGNNNSLHLAANLAPTPQLQSVPGPAFQMQRELQWFKAVEELVYDELKTEKNLADETPRELFFNEHKDLLKDAKEWMKDTSNSCMVVATLVATVAFAAMITVPGGNNGNTGLPILARQKLFLAFSISNAFSMIFSAISLLMFLSMQTSRYTEDDFLDLLPKVLLRGLISLGVAVATMMISFGTAIGLSLQTRLNWAYIPITVVACFPVIIFTWLQLPLLLQALLFKSGPGIFQGQWDRKSLRLRKIGYRLLLANDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXN3</accession>
    <name>A0A068TXN3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
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            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00029903001"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1892195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080188">
        <property type="term" value="P:gene silencing by siRNA-directed DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FDM1-5/IDN2"/>
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    <dbReference type="InterPro" id="IPR005379">
        <property type="entry name" value="FDM1-5/IDN2_XH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596:SF82">
        <property type="entry name" value="FACTOR OF DNA METHYLATION 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03469">
        <property type="entry name" value="XH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="512" mass="58621" checksum="1FD6EEC814049501" modified="2014-10-01" version="1">MAPKRDIGWEHAEPVGGDKKIVQCRYCGKIIHGGITRLKQHIAHIAGQVGACPGSPPDVTLELKKHLNDGKSERATMKKRKAAALNAFYNRSLCGYMHATDDENDDESECDTLEDELLSLEKMQLMLAMEESRQTALIEELHHKSHVSRSRPVTVGCGRSLSTEANVINCNDDDDGQDIDQKGLSDMEVKQLKQALKESRYTAFLEEEQRNCSTSSSFSGKDGEKPGTDSTSCIFPAEEKSIKKLRKMQQISLQIKILRRELDHQRRKMHLAEQGNERLMGDLVHIQKELNHQIKDREKSQAELEHKTLRIEKEQLIAQIDVLKKTLAEKDDELQDMEALNQTLILKERSSNLELQDARKELTSVLSNLVDRTTIGVKRMGEVDQKPFQDVCAKKFSRSDWEVRSVESISLWQEKVSNPGWQPFKNTLKDGKWQEIIDEDDGELKRLRHDWGEDPYAAVVNALLELNEYNPSGRYVVQELWNFKEGRKASLQEVIQCMAQELKNTEAYKRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXN4</accession>
    <name>A0A068TXN4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00032906001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXN4"/>
    <dbReference type="FunCoup" id="A0A068TXN4">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXN4"/>
    <dbReference type="Gramene" id="CDP00812">
        <property type="protein sequence ID" value="CDP00812"/>
        <property type="gene ID" value="GSCOC_T00032906001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXN4"/>
    <dbReference type="OMA" id="YCAHGAE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000327">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000336">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052059">
        <property type="entry name" value="CR_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47973">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="400" mass="44482" checksum="B27E9D1E0F97EC5B" modified="2014-10-01" version="1">MIKSKAFLQGLIKAFVPKNSRGQKEEDLEKIAAQEQKQFQFQVLVAATKNFHRSNKLGEGGFGPVYKGKLDDGREIAVKKLSQSSRQGKKEFMNEAKLLARVQHRNVVNLLGYCAHGPEKLLVYEFVANESLDKLLFKSSGRDALDWNRRHDIIVGVAKGLLYLHEDAHSCIIHRDIKASNILLDDKYLPKIADFGLARLFNEDGTHVNTRAAGTNGYMAPEYVMHGNLSIKADVYSFGVVVLELISGQKNSTFNRDTESTSLLEWAYKLYKKGKHLEIVDPSLVTSANPDQISVCIQIGLLCVQSDPRLRPKMRRVVVMLSRKPGTLEEPTRPGYPGSRYRKSHKPLAVSSTTGTSGASNSHSFTSTTKTNSVTATTTTSALTNPRSDRKGKRPMHHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYS2</accession>
    <name>A0A068TYS2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036458001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYS2"/>
    <dbReference type="FunCoup" id="A0A068TYS2">
        <property type="interactions" value="1648"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYS2"/>
    <dbReference type="Gramene" id="CDP01416">
        <property type="protein sequence ID" value="CDP01416"/>
        <property type="gene ID" value="GSCOC_T00036458001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYS2"/>
    <dbReference type="OMA" id="FYPELYG"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYS2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000702">
        <property type="entry name" value="Trafficking protein particle complex subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43452" checksum="DCB2D8C72C092EE8" modified="2014-10-01" version="1">MATTSTAADSATDPSTPDPQTPVTPPQNLVDPLNNPYNSLNSLCHDLTSLQDLACRGSWRTIIDKIARARSLSLLTKPHEHLIYLTFNLLSLVKLRRFTDANNELQSDLEDDENDGDHPLNSPQYQYETYPHHYPNQQGSMVPFALRWLHAHLPSTIGHKQQSLDRFYTLLDFVREKRRSADGNSGDLWRKREVFVVNTIVSYHLSGKEFKVCVDLMRGLANEKGFEVDAVMLSKLGYVQMQYGDLEGAKRTFGEVEKMVGSGEDDVGLRNLVSRNKALMYLVGKDYVSAVREYEVCIERDGLDAVAINNKALCLMYLRDLSDSIKVLENALERVPTVALNETLVVNLCSMYELAYVNHADIKKTLSNWIARVAPDDFDSSCTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYZ6</accession>
    <name>A0A068TYZ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036563001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYZ6"/>
    <dbReference type="FunCoup" id="A0A068TYZ6">
        <property type="interactions" value="1531"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYZ6"/>
    <dbReference type="Gramene" id="CDP01491">
        <property type="protein sequence ID" value="CDP01491"/>
        <property type="gene ID" value="GSCOC_T00036563001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYZ6"/>
    <dbReference type="OMA" id="AMQDQQH"/>
    <dbReference type="OrthoDB" id="2020732at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36408">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36408:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="326" mass="36655" checksum="6C39634638B027A3" modified="2014-10-01" version="1">MSLASRNLLTSPISQINTTINTSKTHLRNPRLPLLSYPKPFLNPSRFHAQKPHFLKFATFIPPIQNHTWSIQVKSLDLDGTVGEESRSENPANWDVNFDAFLSILEFFCLVSSIAISGILAVNSGFLGGQRMVFRWLGEKGMVWQCVVLVAGVLVGAVIRRRQWRRICQAKYFSRPVNLVERIEKLEENFKSSATVIRALSRQLEKLGIRFRVFRKALKEPIAETAALAQKNSEATRALAIQEDILEKELGEIQKVLLAMQEQQQKQLELILAIAKSGKLWDTKREENHGNNTPAASNSVVDGVQQLGKNQIQAVAGQKESNNDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZF7</accession>
    <name>A0A068TZF7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00032770001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZF7"/>
    <dbReference type="Gramene" id="CDP00713">
        <property type="protein sequence ID" value="CDP00713"/>
        <property type="gene ID" value="GSCOC_T00032770001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZF7"/>
    <dbReference type="OMA" id="WSFDMVV"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP00713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="488" mass="53224" checksum="74B9AC6A2A2F8570" modified="2014-10-01" version="1">MDRYDSSPVAPLIPSQGRSHCIDREVSEQGCYRGEIIEEVKRQLGLALPLIAVSILQYCLQIISIMFVGHLGELPLSSASMATSFASVTGFNVLLGMGSALETLCGQAYGAKQYRMLGIYTQRGMIVLLVLSIFLALIWFYTDHILIVLGQDQEISIEAGKFNRSMIPGLFAYALLQCINRFLQTQNIVFPMMMSSGITALFHVLLCWFLVFKTGFGNSGAALANGISYWVNVFLLTAYIKFSPACSSTWTGFSKEALLDIISFIKLAIPSAIMICLEYWSFEMVVLLSGLLPNPKLETSVLSISLNTCWMVYMISVGLGAAISTRVSNELGAGNPQGARLALGVVVIVALTEGAIVGTTTILVRHIWGKLYSNEEEVVRYVAKMLPLLALSDFFDGFQCVLSGAARGCGWQNLCAFINLGAYYIVGIPSAVLLAFFFHIGGMGLWMGIICGLSVQVVALVTVNLCTDWDNEARMAVNRIQSCSIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZS7</accession>
    <name>A0A068TZS7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">GSCOC_T00036933001</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="25">Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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    <sequence length="911" mass="102209" checksum="CBF0CD8A655EC9D9" modified="2014-10-01" version="1">MKFSSVLLLICFLASIFIFSGFAADSLDAYKSITGRKHLNGLNPPRTPGKRSLLSDSKEADTALVAALDGTIFLLELDSMKPLWSFESGSEIYSSYQAPVDEDKENTSGLGSDYYIDLGDDWELYAHNRLGKLKLTKTLEEYISSTPQIAEDGGIVLGSKKTTAFLVDAKTGRLIYTYRTPESSCPKQNNSENTVIHNSTVEGLGLSQSTDLKADELPLYITRTDYALTSFAPNSNKVLWNMTVAEIGAAFLCEEMERSFGRAILNSGFSEPGFNMPLPCQSMALVYRFRNHDMLEPFLRHGGLPEAHSPEIMLPTSIPKPMLPSQPNVDKVLEFLPSQQNVGKSLDSHDISGEEFVLSLPSVTEDGEMRNVQELKISPGGRLSVVLERIGAISSFPFAVTVGIVIYHLVARKFMLVDNPSNTSSGTVPSKRKKSRKSGKSGSSVEKKDIDTHPNGDSANMDDDDDKNMWLNLSQPTFNIEGRRIGKLFVTTKEIAKGSNGTVVLEGIYEGRPVAVKRLVRAHHDVAFKEIQNLIASDRHPNIVRWYGVEQDQDFVYLALERCICSLDDLIHMFSDISGNLSFSKNLDVEDMAKYQIHLDSVKVVIQDPRLWKSNGYPSPILLKLLRDVISGLVHLHELGIIHRDLKPQNVLIIKDRSLCAKLSDMGISKRLTGDMASLGCGSSGWQAPEQLLLGRQTRAVDLFSLGCVLFFCITGGRHPFGNRLERDVNITKNQVDLFLVEHIPEAMDLFSHLLNPNAEMRPKAVEVLAHPLFWSADLRLSFLRDTSDRVELEDRETDSELLKAIEATAPIALGGKWDEKLEPAFLYNIGCYRRYKYDSVRDLLRVMRNKLNHYRELPMEIQEILGSVPEGYDEYFASRFPKLLIEVYRVMSMYCKEEECFIKYFKCSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZX6</accession>
    <name>A0A068TZX6_COFCA</name>
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF80">
        <property type="entry name" value="F-BOX DOMAIN, LEUCINE-RICH REPEAT DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36066" checksum="C2394B710B1CE912" modified="2014-10-01" version="1">MEEGCDFRPWDELIPDTLGLIFRNLSLLEILTVVPGVCKSWRKAVMGPYCWQEIDIEEWSQHCSPENIDQMLQLLITRSCGSFRKLCVSGISNDLSFAYIANHAKCLQTLRLPRSQISHSIVEQVAGMLSTLTFLDLSYCIKIGAEALEAIGKNCKFLTGLRRIMHPLEVIDKLSQDDEALAIASTMPKLKHLEIAYLLVSTSSVIEILTNCRQLELLDVRGCFNVNLDENFVKKFPRLKLVGPNVVDYYDMNGWDSCSDYSGSSGYLAWDFVAGMGDDYDEISDGYWGDEQQIEDVEMWFYDDVEAMDAGYDWPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0N3</accession>
    <name>A0A068U0N3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039385001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0N3"/>
    <dbReference type="Gramene" id="CDP02100">
        <property type="protein sequence ID" value="CDP02100"/>
        <property type="gene ID" value="GSCOC_T00039385001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0N3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="67" mass="7782" checksum="33E1D8C687DA3FB5" modified="2014-10-01" version="1">MLDRSIRLYEAASRLTQSIQFLLNPDPTSLRRERRRRESSKSTTTDVQHPPPLLATAAYLLLYYSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U191</accession>
    <name>A0A068U191_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037135001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U191"/>
    <dbReference type="STRING" id="49390.A0A068U191"/>
    <dbReference type="Gramene" id="CDP01944">
        <property type="protein sequence ID" value="CDP01944"/>
        <property type="gene ID" value="GSCOC_T00037135001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U191"/>
    <dbReference type="OMA" id="FSITQCM"/>
    <dbReference type="OrthoDB" id="767511at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U191"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="430" mass="48274" checksum="8BA904B821D45FC9" modified="2014-10-01" version="1">MRESPQSSILSGALKGCLGSLDGACIEKLLLHCASALESNDVTLAQQVMWVLNNVASPVGDPNQRLTSWFLKALISRVSRVCPTPMNLNGNSSPQRRLMTVTELAGYVDLIPWHRFGFCASNSAIFKAIQGYNKVHILDLSITHCMQWPTLIDTLAKRPEGPPSVRISVPSWRPPVPPLLNVSSEEVGQRLGNFAKFKDVPFEFNVIGEQPTVPSSPCISTLECSSLQYDFLLNQVLNPSTLKLEDDEALVINCQNWLRYLPDEQNNGASQEISCRDIFLNRIKDLNPCIITVVDEDSELDVSNLTSRITTCFNYLWIPFDALETFLSKDNSQRIEYEADIGHKIENIIAFEGTQRIERLESGTKFSQRMRNNGFFSVPFCEETISEVKFLLDEHASGWGMKKEDDMLVLTWKGHNSVYATAWVPCGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2C0</accession>
    <name>A0A068U2C0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Auxin response factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00036877001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2C0"/>
    <dbReference type="FunCoup" id="A0A068U2C0">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2C0"/>
    <dbReference type="Gramene" id="CDP01733">
        <property type="protein sequence ID" value="CDP01733"/>
        <property type="gene ID" value="GSCOC_T00036877001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2C0"/>
    <dbReference type="OMA" id="WISKFTQ"/>
    <dbReference type="OrthoDB" id="2016915at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2C0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009835">
        <property type="term" value="P:fruit ripening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000047">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF150">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0292">Fruit ripening</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="12">
        <location>
            <begin position="127"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="13">
        <location>
            <begin position="719"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP01733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="845" mass="93890" checksum="F094D6D68E547C34" modified="2014-10-01" version="1">MKLSTSGLGQQAHEGEKKCLNSELWHACAGPLVSLPTVGSRVVYFPQGHSEQVAATTNKEVDAHIPNYPSLPAQLICQLHNVTMHADVETDEVYAQMTLQPLTPQEQKDTYLPVELGTPSRQPTNYFCKTLTASDTSTHGGFSVPRRAAEKVFPPLDFTQTPPAQELIARDLHDVEWKFRHIFRGKFGFLLFGQPKRHLLTTGWSVFVSAKRLVAGDSVLFIWNEKNQLLLGIRRATRPQTVMPSSVLSSDSMHIGLLAAAAHAAATNSCFTIFYNPRASPSEFVIPLSKYFKAVYHTRVSVGMRFRMLFETEESSVRRYMGTITGIGDLDPVRWPNSHWRSVKVGWDESTAGERQPRVSLWEIEPLTTFPMYPSLFPLRLKRPWYPGASSFQDAGNEAVNGMTWLRGETGEQGLHSLNFPSVGMLPWMQQRIDPSMLRNDLNQQYQAMLALQNFGSGDLLKQQMVQFQPPVQYLQHTGSHNTLLQHQQVIQQGVSPHILPPQTQMLSENLNRAQAQQVNNQSEEQQPHHPFPEAYVIQHEQLQQRQSSNIPSPSFSKTDFADSNTKFSASIAPSSMQNVLGSLCSEGSTSLLNFSRTTQTMLNEQPPQQSWVSKYSHGQVNTCSSAASLPPYPGKDGPSGQEACGLDAQNQALFGANIDSAALLLPTTVSSVGTSSIDAGVSSMPLGDSGFQNPLYGFVHDSSELLHGTGQDSPTRARTFVKVHKLGCVGRSLDISRFNSYHELRQELGQMYGIEGLLEDPQRSGWQLVFVDRENDVLLLGDDPWEAFVNNVWYIKILSPEEVQKLGKQEGESLSRIAAERMNSSSGDGRDMVARFPSLGSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2T6</accession>
    <name>A0A068U2T6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039867001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068U2T6">
        <property type="interactions" value="1998"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2T6"/>
    <dbReference type="Gramene" id="CDP02479">
        <property type="protein sequence ID" value="CDP02479"/>
        <property type="gene ID" value="GSCOC_T00039867001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2T6"/>
    <dbReference type="OMA" id="THEVVLY"/>
    <dbReference type="OrthoDB" id="3295at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2T6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000704">
        <property type="entry name" value="Transducin/WD40 repeat-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF17">
        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1637" mass="178452" checksum="ABE2F1A6E303B201" modified="2014-10-01" version="1">MEWATLQHLDLRHVGRSSKSLQPHAATFHPTLAIVAAAVGTHIIEFDAHTGSKIAAIDIGSSVVRMAYSPTSGHAIIAILEDCTIRSCDFDSEQTCVLHSPEKRMEQISSDTEVHLALTSLQPIVFFGFHRRMSVTVVGTVEGGKAPTKIKTDLKKPIVNLACHPRLPVLYVAYADGLIRAYNIHTYAVHYTLQLDNTIKLIGAGAFAFHPTLEWVFIGDRRGTLLAWDVSTERPMMIGITQVGSQPITSVAWLPVLRLLVTLSKDGSIQVWKTRVNVNPNRPPMQANFFETAGIESIDIPRILSQKGGEAVYPLPRIKALEIHPKLNLAAVLFASMTGGDNRKNRSAYTREGRKQLFAVLQSARGSSASVLKEKLLSLGSSGILADHQLQAQLQEHHLKGQNQITISDIARKAFLYSHFMEGHAKTAPITRLPLITILDTKHLLRDVPVCQPLHLELNFFSKQNRVLHYPVRAFYLEGANLMAYNLSSGVDNVYKKLYTSIPGNIEYHAKCIAYSKKKHLFLVVYEFSGTAHEVILYWENTDPRSTNSKANTIKGRDAGFVGPNENHFAILDEDKTGLSLYTLPGVASQESKDNNSMIDGDQAAGPDITDVTAIKGPLQFMFESEVDRIFSTPLESTMLFASHGDQIGLAKLVQGYRLSTADGHFISTKAEGKKSIKLKTSEMVLQEYTCDCVFFTQVYLQLLVLSRQYLACFSYFCRLVHWQETLRGFVAGILTTQRSLTCDYFRSLLWIGPALLFSTATSISMLGWDGKVRTVLSICMPNAVLVGALNDRLLLANPTDINPRQKKGIEIKSCLVGLLEPLLIGFATMQQHFEQKLDLPEVLYQITSRFDSLRITPRSLDILASGSPVCGDLAVALSQSGPQFTQVLRGIYAVKALRFSTALSVLKDEFLRSRDYPRCPPTSHLFNRFRQLGYACIRYGQFDNAKETFEVIADFESMLDLFICHLNPSAMRRLAQRLEEEGADPELRRYCERILRVRSTGWTQGIFANFAAESMVPKGPEWGGGNWEIKTPINMKDIPQWALAAEVMPYMRTDDGTIPSIVTDHIGVYLGIIKGRGNVVEVREDSLVKAFKAEGSNIKANGLQTALATSTPGKSNGVPEGEPKSNSLMGLETLSQQFSGSHAVDEQAKAAEEFKKSLYGSAADGSSSDEEEGSKTKKLHIRIRDKPVTSATVDVNKIKEATKQLGLPMGRTKSSTGSSPDLGLILSQPAPPTTGSVTAPTVSAPTDPFGTDSLVQPTSTSQPSPISTGAGVTARPIPEDFFQNTISSIQVAASLPPPGTYLSQLEKNSQGLQGNKVVANQESAPVADIGLPDGGVPPQATQQPVSSDSIGLRGGTIPPQLSVQPVMPVQSQPQMAQVPISTQPLDLSSLEAPGSGTPGRAPEHPTSPKAVRPGQVPRGAAASFCFKTGMAHLEQNQLPDALSCFDEAFLALAKDQSRGADIKAQATICAQYKIAVTLLREISRLQKVQGPSAISAKDEMARLSRHLGSLPLLAKHRINCIRTAIKRNMDVQNYAYSKQMLELLLSKAPAGKQDELRSLIDICVQRGLSNKSIDPLEDPSQFCAATLGRLSTIGYDVCDLCGAKFSALSTPGCIICGMGSIKRSDALAGPVPSPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U387</accession>
    <name>A0A068U387_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00040065001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U387"/>
    <dbReference type="STRING" id="49390.A0A068U387"/>
    <dbReference type="Gramene" id="CDP02619">
        <property type="protein sequence ID" value="CDP02619"/>
        <property type="gene ID" value="GSCOC_T00040065001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U387"/>
    <dbReference type="OMA" id="KWRSKIH"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U387"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000127">
        <property type="entry name" value="Probable glycosyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF15">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP02619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="469" mass="54134" checksum="13DD4C4D3F2C451A" modified="2014-10-01" version="1">MLHTLYHKQSGSGSRKEDTQTLPLRKEKVVAMSKAKLHSRPPSLSRDKSVFIAAAITVLLVCVIWSFTGPFSNFPTLFSSDCSGSPGQFFNRADDPQETTFYDDPEISYTVDGNPVKNWDEKRKEWLKLHPTFAAGVQNRMLLLTGSQPSPCKSPSGDHLLLRCFKNKVDYCRIHGCDVFYNNAYLNPKMKSYWAKIPLIRASMLAHPEAEWIWWMDSDAIFTDMDFKVPLRRYKHHNFVVHGWPNLIYEKKSWVAVNAGIFLIRNCQWSMEFLDVWARMGPQSPEYARWGQTLRSTFKDKMFPESDDQSALVYLLLKEKRKWGDMMYVENEYSLHGYWAAVVGRIDNITGRYEKIERQEVKLRRRHAEAVGERYGKLWEEHLEDAGDRKGGWRRPFITHFTGCQPCSGDHNPSYVGKDCWVGMERALNFADNQVLRNFGFVHPDLRNGSVSPLAFDFPGAEASEDSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3F0</accession>
    <name>A0A068U3F0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00039426001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Potassium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3F0"/>
    <dbReference type="FunCoup" id="A0A068U3F0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3F0"/>
    <dbReference type="Gramene" id="CDP02133">
        <property type="protein sequence ID" value="CDP02133"/>
        <property type="gene ID" value="GSCOC_T00039426001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3F0"/>
    <dbReference type="OMA" id="ISMYVWH"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3F0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF10">
        <property type="entry name" value="POTASSIUM TRANSPORTER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="24"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="533"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU321113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP02133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="745" mass="83771" checksum="EC1EACB125075A70" modified="2014-10-01" version="1">MALMDVETRTNPIKKESWRAVLTLAYQSLGVVYGDLSTSPLYVYKSTFAEDIHHSETNEEIYGVVSFIFWTLTLIPLLKYVFIVLRADDNGEGGTFALYSLLCRHARVSTLPNGQVADEELYEYKKDEIVSADKGFGLRLRSTLEKHKFLQRILLVLALIGTCMVIGDGVLTPAISVFSAVSGLELSMAKPHHQYVEVPVACVILLILFYLQHYGTHRIGFLFAPIVITWLFCISAIGLYNICHWNPHVYRAVSPYYMYKFLKKTRKGGWMSLGGILLCMTGSEAMYADLGHFSQLSIKIAFTCVVYPALILAYMGQAAYLSKHHLIENDYRIGFYVSVPEKIRLPVLVIAILAAVVGSQAVITGTFSIIKQCSALGCFPRVKIIHTSSEVHGQIYIPEINWTLMLLCLAVTVGFRDTKHISNASGLAVITVMLVTTCLMSLVIVLCWRRSGFLAICFIFFFGSIEALYFSASLIKFLDGAWVPIALSFIFLMIMYTWNYGTLKKYEFDVQNKVSIQWLLGLGDNLGIARVRGIGLIHTELVSGVPSIFSHFVTNLPAFHQVVIFLCIKSVPVPHVRPEERFLVGRVGPKGYRLYRCIARYGYRDAHMDDVEFEKDLACSIAEFIRSEGLENNNVNIEDDERMTSREIISSPRVPNKKVRFLVPKNPEMDTSAVVELQELMEAREAGLAFILGHCYVRAKSGSSFMKRLAIDVGYDFLRRNSRGPSYALSFPRASTLEVAMVYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3G2</accession>
    <name>A0A068U3G2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00041248001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3G2"/>
    <dbReference type="FunCoup" id="A0A068U3G2">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3G2"/>
    <dbReference type="Gramene" id="CDP02852">
        <property type="protein sequence ID" value="CDP02852"/>
        <property type="gene ID" value="GSCOC_T00041248001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3G2"/>
    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3G2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="7">
        <location>
            <begin position="148"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="825"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP02852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129743" checksum="9A4164C1695688F9" modified="2014-10-01" version="1">MSSNVTEGVVQTGKLLVHIAENGHSFELECDEYYIVEAVQRFLESVTGIQFNDQLLLCLDMKLESQRPLSTYRLPSGDREVFLFNRARMRSNSEPPADEQVDIIDIPDPQVPSSSHNRHPLDDAPDPALKALPSYERQFRYHSQFGDAIYSRTRAKLDICERLFREQKVQERALEIAGHNLDHFYRMILQNYRDFEKFYSQQHRRHANLLANFGRDIEKLKACKILPALQGASRRCLLDFVKEENLQKAVEDCSNSHKQFENKVLDFKQEFGQLKRNAEHLFSSKASFHVGEIETTLKEHQRYINEQKSIMQTLRKDVNTVKKLVDDSLSSKLSSSLRPHDAVSALGPMYDSHEKSCLPKMQDCERAISKMLNFCQDKKNEMNVFVHKYMQQIAYIQYTIKGVRFEFSVFQELLKRQSDQFEHLRVVHGIGPAYRACLAEVVRRKATMKLYMGMAGQLAERLATKREAEVRRREEFLRVHSLYIPRDILTSMGLYDTPNQCDVNITPFDTNLLDIDISDVDRYAPEHLVGLLSKTEKQGTSRGSFSMSNDSSHTAEIEESVVDSPEKFDSMDLLEGSELAEIAGTSKMEVENAKLKAELASKIAMICSMSPEFDYESLDDSRLDSLLKSAAEKTTEALNLKDQYEKHLQTMLKTKQIQCESYEKRIKELEQRLSDQYLQARELPADEDTSKLTHSAVRTDDNKSEITGVGETHVEHAPAETMDEFSCASSSTNKTGLLFKQGKAQEGLDDNMTDSSGMLNPQLDSSMIDPHRDEGHLCDKEGNDSYAGLSLATSMAVSMSQPSNALPPEIATEQGLDCKKGADLVQELQGALEEKAIQLGEAENKLKALIEEVAKLGRELEISRKLLDESQMNCAHLENCLHQAREEAQTHRCAADRRASEYSALRASAVKMHSLFERLKTCVSSSGIVGLAESLRGLALSLGNSISENEDDGTVAFRECIRVLADRVGVLSRQRLDLLDRHSKAEANTEQLTKELDEKKELVKTLYVKHQMEKQQANKEKISFGRLEVHEIAAFVLNSAGHYEAINRNSSHYYLSAESVALFADHLPNRPAYIVGQIVHIERQSVRSPPPAGDQNRDRLDVLTSDAGSNLLTLNAGSTLNPYGLPVGCEYFVVTVAMLPDTTIHSPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4N4</accession>
    <name>A0A068U4N4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00015924001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4N4"/>
    <dbReference type="FunCoup" id="A0A068U4N4">
        <property type="interactions" value="1678"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4N4"/>
    <dbReference type="Gramene" id="CDP03525">
        <property type="protein sequence ID" value="CDP03525"/>
        <property type="gene ID" value="GSCOC_T00015924001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4N4"/>
    <dbReference type="OMA" id="PKEPWDV"/>
    <dbReference type="OrthoDB" id="1920276at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4N4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33400:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN LUMINIDEPENDENS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33400">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP03525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114839" checksum="2DD59DDD0162378F" modified="2014-10-01" version="1">MELQLANENQLELVVSNSPTSLQDLLDSQTDLFRGQIDELENIVLTQCQLTGVNPLSQEMAAGALSIKIGKRPRDLLNPKAIKYMQSIFSVKDAITKKETREISALYGVTATQVREFFTVQRARVRKFVRLSREKSNRSSSCKEVLDGIPQGCDPNEPLTPVPLDSVGPTSTEEGPTSLTQNEVLPSADQSDKYFLDNIFSLMRKEESFSGQVKLMEWILQIQNSSVLYWFLNNGGVMILATWLTQAALEEQTSVLRVILKVLCHLPLQKALPVHMSAILQSVNSLRFYRISDVSNRARVLLSRWSKAFARSQALRKSNGTKSAIDAQDEMLLKQSIHEVMGNESWDSKIDVLEDNSTLMDESLGNFRKLESQPAKLLTASADDQNRKLIRGALASQNRERRKVLLVEQPGQKSAGRTTQTARSTTAPQGRPLSADDIQKAKMRAQFMQSKYGKTNSISDASPQMQLEGANKSALSNTSILVPPSKAHTGTKIEETNKSGCSPVGVANPEDASVDKQNNCHSEEPPWKKCKRFQIPWQIPPEIGISVSWRVGAGENSKEVEVQKKRIHRERETVYKTFQEIPSDPKEPWDQEIDYDDSLTAEIPIEQLPDGEFAGASVSPRENERTAGTSGNSSSLIAGGSMPEPDLELLAALLKNPELVFALTSGQAGNLSNEETIKLLDMIKANEMNSLANITASSGKSKPEEKVEVSLPSPTPSSDPVTSARKPDYAKNPFSQQKTTLTNEILGIPGTAAIRSQESVPASNVVQSHNLPTGAMVAEPSTTFPQLAQHAIPHALLSEEKLRASGLVQPQVLPATVLAPQQAATVQQLAQQMAPQVLGSHEQRLLPLTSSLHHNIPAYASNAQLKSSSELLLNMNNTSLSRSPPLTNSMNGVAPAMVVNPSSMSLVGSPLRPQTQMQPSYAPEAPLAHSWRPRPGLDPISRQNNVTPDEYEAFVGASARAPVARSSWEKNDLMVGPDFESWSPENSPTRSHGYVPGWNVQEPMVNPGQSYRPERPIYRHAGYPPSSGYHDPGISGTKRWRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5R4</accession>
    <name>A0A068U5R4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calmodulin-binding protein 60 B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00041396001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant ACBP60 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5R4"/>
    <dbReference type="FunCoup" id="A0A068U5R4">
        <property type="interactions" value="1667"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5R4"/>
    <dbReference type="Gramene" id="CDP02958">
        <property type="protein sequence ID" value="CDP02958"/>
        <property type="gene ID" value="GSCOC_T00041396001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5R4"/>
    <dbReference type="OMA" id="WTNNRDK"/>
    <dbReference type="OrthoDB" id="512636at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5R4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046829">
        <property type="entry name" value="Calmod_bind_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046830">
        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF100">
        <property type="entry name" value="CALMODULIN-BINDING PROTEIN 60 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20452">
        <property type="entry name" value="Calmod_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein central" evidence="10">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein C-terminal" evidence="11">
        <location>
            <begin position="315"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP02958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="70874" checksum="EA20E312F645DAC5" modified="2014-10-01" version="1">MQTRKRILDGEDDQQQERKRPALASVIVEALKVDSLQKLCSSLEPILRRVVSEEVERALAKLGPAKLTGRSSSPKRIEGPDGRNLQLHFRSRLSLPLFTGGKVEGEQGAAIHVVLIDANTGHVVTSGPESCVKLDVIVLEGDFNTEDNESWTQEEFESHVVKEREGKRPLLTGDLQVTLKEGVGTLGELTFTDNSSWIRSRKFRLGLKVASGYCEGIRVREAKTEAFTVKDHRGELYKKHYPPALNDDVWRLEKIGKDGSFHKRLNNAGIFSVEHFLRLVVTDPQKLRTILGSGMSNKMWDALIEHAKTCVLSGKLYVYYSDDSRNVGVVFNNIYELSGLIASEQYFPADSLSDSQKLYVDGLVKKAYDNWNLVIEYDGKSLLNFKQNKKSSASRDELPVGPVDYPNALDNQLSDPPRLPVPVPSEPSPVDPNMLIGGYNDNMATRYANQSQILNSSSRNQYGSTSYGLPDQQISNSHQIQNTRYDNRAALALAPPQSSSSFQTVGSSVQPSNLNPFEDWTQNRDKSVDDFLSEEEIRLRSHEMLENEDMQHLLRLFSMGGHAAVNVPDDNFAFQSYMPSPSPNYSYEEDRTRSGKAVVGWLKIKAAMRWGFFIRKKAAERRAQIVELEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6F4</accession>
    <name>A0A068U6F4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myb-related protein Myb4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00016214001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DH200</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
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            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
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    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
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                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DH200</strain>
        </source>
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    <reference evidence="10" key="4">
        <citation type="submission" date="2017-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="de Groot N.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="10">Bark tissue</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AXU22041.1"/>
        <property type="molecule type" value="mRNA"/>
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        <property type="protein sequence ID" value="CDP03739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068U6F4"/>
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        <property type="protein sequence ID" value="CDP03739"/>
        <property type="gene ID" value="GSCOC_T00016214001"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="Myb_TF_plants"/>
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    </dbReference>
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        <property type="entry name" value="MYB-RELATED PROTEIN MYB4"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="116"/>
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    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="62"/>
            <end position="112"/>
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            <end position="216"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AXU22041.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP03739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="277" mass="31234" checksum="B2041DC079AA28E0" modified="2014-10-01" version="1">MGRAPCCEKMGLNKGPWTKEEDQILISYINENGRGNWRALPKKAGLLRCGKSCRLRWTNYLRPDIKRGNFTQEEEDTIIKLHQALGNRWSAIAATLPGRTDNEIKNVWHSHLKKRLIPQQDHQGQAVRKTQPEQGTNKALSVEKPKFHCQDSNSSPVKIIVSKQEPGTNNQSSSLQYSSSDDISSSLSFTDATTTTTIPDNPTEIYLTNSGDGDSVSNKHQELDQDIWHDVVSSQDHSLSPVLHRGGCGFNPFTNDDINFWCDLFTRTEDISHLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8V8</accession>
    <name>A0A068U8V8_COFCA</name>
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        <recommendedName>
            <fullName evidence="10">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00019812001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">cv. DH200-94</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRM1_repeat_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF18787">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP04941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1066" mass="122810" checksum="9E47099513FB66CB" modified="2014-10-01" version="1">MAAADKLRDLSQPIDVSLLDATVAAFYGTGSKEERTAADHILRDLQNNPDMWLQVVHILSNTQNLNTKFFALQVLEGVIKYRWNALPVEQRDGMKNYISEVIVKLSSDEASFRRERLYVNKLNIILVQILKHEWPARWRSFIPDLVAAAKTSETICENCMAILKLLSEEVFDFSRGEMTQLKIKELKQSLNSEFQLIHELCLYVLSASQRTELIRATLATLHAFLSWIPLGYIFESPLLETLLKFFPVPAYRNLTLQCLTEVAALNFGDFYNVQYVKMYNVFIMQLQAILPLTTNIPEAYANGSSEEQSHIRVLESAPENVNTLLMGLEYLINISYVDDTEVFKVCLDYWNSLVLELFEAHHNSENAAATAMIGLQHMPMGLVDGLGSQLLQRRQLYAEPMSKLRLLMISRMAKPEEVLIVEDENGNIVRETMKDNDVLVQYKIMRETLIYLSHLDHEDTEKQMLRKLNKQLNGEDWTWNNLNTLCWAIGSISGSMMEEQENRFLVMVIRDLLNLCEITKGKDNKAVIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHPGVQDMACDTFLKIVQKCKRKFVILQLGESEPFVSELLTTLPTTIADLQPHQIHTFYESVGHMIQAEPDPQKRDEYLQRLMELPNQARSILLRWNEIIGQARQSVDFLKDQDIIRAVLNILQTNTSVASSLGTYFLSQISLIFLDMLNVYRMYSELISTSLAQGGPYAYRTSIVKLLRSVKRETLKLIETFLDKSEDQPQIGKQFVPPMMDPILGDYARNLPDARESEVLSLFATIINKYKGAMIEDVPRIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATHCFPALIRLSSEQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNFQASEFCNQFFRTYFLMIEQEIFAVLTDTFHKPGFKLHVLVLQHLFCLVESSGLTEPLWDASSVAYAYPNNAVFVREYTIKLLSTSFPNMTATEVAQFVNGLFESRTDLPTFKNHIRDFLAQSKEFSAQDNKDLYAEEAALQRERERQRMLSIPGLIAPNEIQDEMVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8W2</accession>
    <name>A0A068U8W2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00018729001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8W2"/>
    <dbReference type="Gramene" id="CDP04677">
        <property type="protein sequence ID" value="CDP04677"/>
        <property type="gene ID" value="GSCOC_T00018729001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8W2"/>
    <dbReference type="OMA" id="TESNWIL"/>
    <dbReference type="OrthoDB" id="1727045at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8W2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP04677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="377" mass="41044" checksum="2D38F024E7E47BAC" modified="2014-10-01" version="1">MANWKERCCYGEVFPFTAMVTVECVSVGLSTIFKAATLKGLNYRVFMLYSNGLSALILLPLCFFFHRKSRLPPLTFGLLARFFFLGTLGFLGQFLGSKGIEYSTPTLASAMSNLTPACTFILAVLLRMEKLKVKSLSSQVKVMGSVITIAGALVVVLYKGPVQMRSPTSSASVFAQQPALVNVTTGAEQSDWIKGGALLAADYVIASVWYIYQTKAIVDYPAELVVVFFYNLSCAILTIPVCLIGVPNSSAWNILKPDVRLYSVVYAGVMGSGFGLLVHTRCLHVKGPVYVALFRPLSIAIAAVMGFIFLGDNFYLGSLIGSLIISLGFYMLIWAKAQEVNAERSPEGKFVASSSANAPLLEQYDDSRNEEREPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA09</accession>
    <name>A0A068UA09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00017841001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SHL1/EBS protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA09"/>
    <dbReference type="STRING" id="49390.A0A068UA09"/>
    <dbReference type="Gramene" id="CDP04448">
        <property type="protein sequence ID" value="CDP04448"/>
        <property type="gene ID" value="GSCOC_T00017841001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA09"/>
    <dbReference type="OMA" id="PKPYMDY"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04714">
        <property type="entry name" value="BAH_BAHCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000019">
        <property type="entry name" value="Chromatin remodeling protein EBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24572" checksum="67630672A91DD5B5" modified="2014-10-01" version="1">MAKTRPGKRDLDSYTIKGTNKVVRAGDCVLMRPSESDTAPYVARVEKIEADNRSNCKVRVRWYYRPEESLGGRRQFHGAKELFLSDHLDVQSADTIEGKCIVHTFKNYTKLENVRPEDYYCRFEYKAATGAFLPDRVAVYCKCEMPYNPDDLMVQCDGCKDWYHPACSGMSIEQAKQLDLFVCSDCASVDVKKPPTKLTESPVMNGKLETKRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAK9</accession>
    <name>A0A068UAK9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00020637001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAK9"/>
    <dbReference type="STRING" id="49390.A0A068UAK9"/>
    <dbReference type="Gramene" id="CDP05531">
        <property type="protein sequence ID" value="CDP05531"/>
        <property type="gene ID" value="GSCOC_T00020637001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAK9"/>
    <dbReference type="OMA" id="WNRINAR"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAK9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF96">
        <property type="entry name" value="TYROSINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52895" checksum="AB6799D1BB86B544" modified="2014-10-01" version="1">MGSFNIHPDFQNEFSYATSPLDPEEFRRQGHMVIGYLADYYQNIEKYPVRSQVEPNYLRSHLPDSAPCNPEPIENILRDLQKHIIPGLTHWQSPSHFALFPCATSTAGFLGEVLSTGFNVVGFDWISSPAATELENIVMDWFGKLLKLPGSFLFSGGGGGVLQGTTYEAMLSTLAAARDQMLRKIGRNNIGKLVVYLSDQTHFSFQKAAQIAGINPSNFRVISTTKDDEFSLCPNSVRSAIIADVEGGLVPLYLCATVGTTLSTAVDPLGPICNIAEEYDMWVHVDAAYAGSACICPEFRHFLDGALSTKPEILRNQATDSKQVVDYKDWQISLSRRFRALKLWLVLRSYGVVNLQKFIRGHVNMAKHFEQLAAMNKRFEIVVPRKFSLVCFRISPSAMNQNCKILSTEEDVNLINQKLVESLNASGHVYMTHGVIGGIYFIKFAIRGPLTDYRHVDMAWTLIEDHAEALLKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAV8</accession>
    <name>A0A068UAV8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00020775001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAV8"/>
    <dbReference type="STRING" id="49390.A0A068UAV8"/>
    <dbReference type="Gramene" id="CDP05621">
        <property type="protein sequence ID" value="CDP05621"/>
        <property type="gene ID" value="GSCOC_T00020775001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAV8"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAV8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065">
        <property type="entry name" value="OS10G0469600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52270" checksum="095CD80AC4AEE2F1" modified="2014-10-01" version="1">MHNRSSLPSILDRRNPFKNIIIVVTCIIQTHDSCTFAGAVPDEVWNLTLLSSLDFGDNKLTGGIPEKIGNLQRLELLNLGNNTLSGSMPAGIFNISSLQYIGLHRNKFSGTIPLTMSSKLSKLKFLYLCQNYLSGVIPNTISNASQLVYLLLHGNELTGSVPSSLGSLRNLQFLLLASNRLSSESSNPELSFFTFLTTCRFLRYLTVDQNPLNGFLPSSLSNYSTSLEVLHAANCQIKGNIPVGISNLSTLLKLDFSSNELIGSVPKTINRLANLQEFSLGWNQIRDVLDIFCGLHSLGNLALSQNQFFGSIPECLGNMTSMRMISLDSNNLTSTIPANLLSMKDLLVLNLSSNFFSGSLSQEIRNLKAAYSLDFSFNQLSGQIPTSVGELQTLQYLSLAKNSLQGSIPESISNIFNLEYLDLSHNNLSGVIPKSLEALKSLEEFNVSFNRLSGEIPRGGPFRNFTSQLFMNNEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBG5</accession>
    <name>A0A068UBG5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00019871001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>salicylate + NADH + O2 + H(+) = 2,3-dihydroxybenzoate + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30762"/>
            <dbReference type="ChEBI" id="CHEBI:36654"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBG5"/>
    <dbReference type="FunCoup" id="A0A068UBG5">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04983">
        <property type="protein sequence ID" value="CDP04983"/>
        <property type="gene ID" value="GSCOC_T00019871001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBG5"/>
    <dbReference type="OMA" id="EHTDYEC"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBG5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000007">
        <property type="entry name" value="Protein DMR6-like oxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP04983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="38262" checksum="E3BE0B13432E6991" modified="2014-10-01" version="1">METKVISSGIKYTSLPESYVRPESERPRLSEVSDCQNVPVVDLGFGDRNLMVRQIGDACRDYGFFQVINHGVSKDAVDKMLETATEFFSLPVEEKLKLYSDDPSKTTRLSTSFNVKKETVHNWRDYLRLHCYPLEKYVPEWPSNPPSFKEMVSNYCVQIRELGLRLEEAIAESLGLDKECIKKVLGDQGQHMAVNYYPPCPQPDLTYGLPGHTDPNALTILLQDLNVAGLQVLRDGRWLAVKPHPDAFVVNIGDQLQALSNGIYKSVWHRAVVNADQPRLSVASFLCPCDHAVISAPKPLTADGSPVVYRDFTYAQYYKKFWSRNLDQEHCLELFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC76</accession>
    <name>A0A068UC76_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA cleavage factor Im 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00020177001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <text evidence="6">In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC76"/>
    <dbReference type="FunCoup" id="A0A068UC76">
        <property type="interactions" value="3226"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC76"/>
    <dbReference type="Gramene" id="CDP05213">
        <property type="protein sequence ID" value="CDP05213"/>
        <property type="gene ID" value="GSCOC_T00020177001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC76"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000020">
        <property type="entry name" value="Pre-mRNA cleavage factor Im subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="200" mass="22947" checksum="98C3BB55B7BF80B7" modified="2014-10-01" version="1">MVTSSVVNTYPLSSYTFGTKEPKMEKDTSVADRLARMKVNYMKEGMRTSVEGILLVQEHNHPHILLLQIGNTFCKLPGGRLKPGENEIEGLKRKLSSKLAANSAALQPDWQIGECVAIWWRPNFETIMYPYCPPHITKPKECKKLFLVHLSEREYFAVPKNLKLLAVPLFELYDNVQRYGPVISTIPQQLSRFQFNMIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCB7</accession>
    <name>A0A068UCB7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021135001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCB7"/>
    <dbReference type="STRING" id="49390.A0A068UCB7"/>
    <dbReference type="Gramene" id="CDP05839">
        <property type="protein sequence ID" value="CDP05839"/>
        <property type="gene ID" value="GSCOC_T00021135001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCB7"/>
    <dbReference type="OMA" id="DGSKQYM"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCB7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044205">
        <property type="entry name" value="KIC/PBP1/KRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319:SF2">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN PBP1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="110" mass="12472" checksum="0F6AF21F453AB54E" modified="2014-10-01" version="1">MDVDELYDFEDYFPSMIQRLGSEGFMGELCSGFYLLMDVTKGLITFESLKKNTLVLGLHDLGDDEIVCMLAEGDMDGDGALNQMEFCILMFRLSPGLMDGSKRWVEEMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD19</accession>
    <name>A0A068UD19_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme-binding protein 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021451001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD19"/>
    <dbReference type="FunCoup" id="A0A068UD19">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD19"/>
    <dbReference type="Gramene" id="CDP06084">
        <property type="protein sequence ID" value="CDP06084"/>
        <property type="gene ID" value="GSCOC_T00021451001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD19"/>
    <dbReference type="OMA" id="YEIRTYH"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD19"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF25">
        <property type="entry name" value="F3F9.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657547" description="Heme-binding protein 2-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25643" checksum="78846FF7595DAF88" modified="2014-10-01" version="1">MASFLDLFKVSFLWSLLSIGSNLGTLKGSSSGHVGVFPPTCNRIECPSFDVIHSGNGFEIRRYNSPVWMSTSPIDDISFVGATRTGFLQLFDYIQGKNEYQQQIEMTGPVITEVKPSDGPFCASSFVVSFFVPKENQANTPPAKGLHVQRWGQTHVAVRQFSGFVADEDVGKEAASLYNSIAGTIWSDAIDKSHAGENTTLYIVAQYNSPFEFENRVNEIWLTFDMNEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE83</accession>
    <name>A0A068UE83_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00023479001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="protein sequence ID" value="CDP06577"/>
        <property type="gene ID" value="GSCOC_T00023479001"/>
    </dbReference>
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    <dbReference type="OMA" id="HNEILCH"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801:SF5">
        <property type="entry name" value="OS05G0286100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OS07G0101800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A068UGK8</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="276" mass="31365" checksum="848646DBF4BF26BC" modified="2014-10-01" version="1">MPCRVFLQSSPPIPAALGERERVNAYGFTYVRFTKSCNACSYNFVSKNSSKYRRKKKRDSMAMRSQPSCKRKILPSPPACCIAILATHTCQTFNEISSSPGSSFPFYIYPGSLFLISVLSITPPPFLNRPSLDFMQVLRFFHTLEQNTSMKVIQGKFLRACLRKCRMLDTKAISPAPCDRCWQLLSSRSVRKKKKTVPRDVPKGHLAIYVGEFRKRFVIKITLLDHPLFRALLDHAQEVYDFTADSKLCIPCDESIFLSVVRCATSPENQPICISL</sequence>
</entry>
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    <accession>A0A068UHI2</accession>
    <name>A0A068UHI2_COFCA</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Rubiaceae</taxon>
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            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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                <person name="Perrotta G."/>
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                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00025024001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHI2"/>
    <dbReference type="OMA" id="MQLMRAR"/>
    <dbReference type="OrthoDB" id="1735564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHI2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37173">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37173:SF1">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="372" mass="40162" checksum="36EBDC91CA3DF732" modified="2014-10-01" version="1">MALSAPPPPPPDPAPSSSTTTAVATTSTTTRPPFPPNPRNPPTPPPPPPPPHFHPHPLHPHHYPAPFYPHLINSRLPASPNSNYPPPSHDVTTTANATTTLYPVASSGRGFLQKHPHSSVPVNNSINPNSHLYAAGAARPGVGISYPRPLFGYSHPDPGLVAGTGMGMGMGYVSGRSIPHLQHPAGGGATVMPGVIKGVPISASASSQPQHKVSLSSTPVSDSNGHKEMSFCRERGRDDSFVTIRDRKVRVSESASLYAHCRSWLRNGFPEESQPINMDAARSLPRPLPLPAQGNVSPVKKDNPKEEEEVEGSVDNLTSEELLQTHIKRAKRVRSRLREERLQRIARYKTRLALLLPLMVEQQMRNDSASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI57</accession>
    <name>A0A068UI57_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00025544001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI57"/>
    <dbReference type="STRING" id="49390.A0A068UI57"/>
    <dbReference type="Gramene" id="CDP07982">
        <property type="protein sequence ID" value="CDP07982"/>
        <property type="gene ID" value="GSCOC_T00025544001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI57"/>
    <dbReference type="OrthoDB" id="2013099at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI57"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="56" mass="6239" checksum="C496EE3DEC45166D" modified="2014-10-01" version="1">MQIFMEILMGKTITLEVDSSDTIDNVKAKIQDKERHPPETNNASTSSASSWRTAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJP8</accession>
    <name>A0A068UJP8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00027363001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJP8"/>
    <dbReference type="FunCoup" id="A0A068UJP8">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJP8"/>
    <dbReference type="Gramene" id="CDP08459">
        <property type="protein sequence ID" value="CDP08459"/>
        <property type="gene ID" value="GSCOC_T00027363001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJP8"/>
    <dbReference type="OMA" id="KGNEPRY"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000022">
        <property type="entry name" value="Probable 2-oxoglutarate-dependent dioxygenase AOP1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="161"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="313" mass="35626" checksum="4C2B3B17995A58E9" modified="2014-10-01" version="1">MDSETIKLPAIDFSQPGLKPGNPEWDSVKGQVRKALEEFGCFEAMYDKISLELQKSFFKALEELFNLPLQTKQRNASKKIYHGYIGQYPIFPLYESMGLDDANILEKVESFTDLLWPEGNSNFCKTVHSYSEQISELDKIVRRMILESLGLEKYMDEHMELTNYLLRAMKYEGPQTTETKVGLPAHTDKNILSILCQDQIRGLQVLTKDGHWIDVEPSPGSFTVMIGDALFAWTNGRLHCPFHRVMMTGNIARYSAGIFSMPKAGYIIKAPEELVDEEHPLLFKPFDNVEFLSFLRTEAGKGAQFALKTYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJT0</accession>
    <name>A0A068UJT0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Squalene cyclase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025375001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJT0"/>
    <dbReference type="STRING" id="49390.A0A068UJT0"/>
    <dbReference type="Gramene" id="CDP07888">
        <property type="protein sequence ID" value="CDP07888"/>
        <property type="gene ID" value="GSCOC_T00025375001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJT0"/>
    <dbReference type="OMA" id="ISENMWR"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJT0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009686">
        <property type="term" value="P:gibberellin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF30">
        <property type="entry name" value="COPAL-8-OL DIPHOSPHATE HYDRATASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17836" checksum="097E46C735814B78" modified="2014-10-01" version="1">MDDGRITISAYDTAWIALIEDVNGSDNPQFPSSLQWIIDNQLPDGSWGEAHFCPYDRLLNTLACVIALKSWTTHEDKIAEGIAIIKTLLDMCKLENVESMICGFEVIFPALLERARNLGIEIPSDTPFVKEICAARDLKFERCSNRSKISLVCASREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL16</accession>
    <name>A0A068UL16_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00028356001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sodium/anion cotransporter (TC 2.A.1.14) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL16"/>
    <dbReference type="FunCoup" id="A0A068UL16">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL16"/>
    <dbReference type="Gramene" id="CDP09146">
        <property type="protein sequence ID" value="CDP09146"/>
        <property type="gene ID" value="GSCOC_T00028356001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL16"/>
    <dbReference type="OMA" id="FYKHPKD"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000142">
        <property type="entry name" value="probable anion transporter 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF424">
        <property type="entry name" value="ANION TRANSPORTER 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP09146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="418" mass="45313" checksum="2A64A8DF2689F030" modified="2014-10-01" version="1">MLALALALCNADRVVMSVAIVPLSLSHGWRQSFAGVVQSSFLWGYLISPIAGGTLVDLYGGKVVMAWGVTLWSLATFLTPWAAENSLCALLAMRMLLGIAEGVALPCMNNMIARWFPQTERSRAVGLAMAGFQLGSAIGLTLSPILMSQGGLYGPFVIFGLSGFLWVLVWISATSSTPDKCHQISAYELRYIQNDGNMQSVIKDKSKKSKVIPPFKRLLSKLPTWTLIVANAMHSWGFFVILSWMPIYFKTIYHVDLRQAAWFSAVPWSMMAVAGYFAGVLSDMMIQRGISVTLTRKIMQSIGFIGPGIALVGLTMARSPSNASAWLTLAVGLKAFSHCGFLVNLQEIAPQYSGVLHGISNTAGTFAAIVGTVGAGYFVELVGSFKGFLLLTAFLYFSAALFWNFFATGGRVNFDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULX3</accession>
    <name>A0A068ULX3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00028572001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULX3"/>
    <dbReference type="Gramene" id="CDP09282">
        <property type="protein sequence ID" value="CDP09282"/>
        <property type="gene ID" value="GSCOC_T00028572001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULX3"/>
    <dbReference type="PhylomeDB" id="A0A068ULX3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF726">
        <property type="entry name" value="OS07G0169600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="276" mass="30955" checksum="5CE00552601933C7" modified="2014-10-01" version="1">MAFLLSSWSSNLKSLPENYIVPVEKRPGMPVPISKDIPVIDLGEEDRANRIQKIMKASQEFGLFQVINHGVSEELMTDAVNVGREFFSLPAEEKAKFVDQDAQNGCMVNTTSGSYRNGCMRKRGEPFIEEALAIREALLIGQEAGWRRIEVQSDSKALIEKITSVLQIVSGGLGLTKEDPDNYDILLMVHSYLECPDPTSALVIAGHHDGNLITVLPQHIMDCKYSRMGIGLVWSFFQMDLSSTYVFSLEVHINYLMHRSSGYKLKPVLGHHWLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN04</accession>
    <name>A0A068UN04_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028166001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN04"/>
    <dbReference type="STRING" id="49390.A0A068UN04"/>
    <dbReference type="Gramene" id="CDP09003">
        <property type="protein sequence ID" value="CDP09003"/>
        <property type="gene ID" value="GSCOC_T00028166001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN04"/>
    <dbReference type="OMA" id="GYPTHAQ"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN04"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080037">
        <property type="term" value="P:negative regulation of cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000762">
        <property type="term" value="P:regulation of phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22152">
        <property type="entry name" value="F-box_AtAFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044595">
        <property type="entry name" value="KMD1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46407">
        <property type="entry name" value="OS02G0208700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46407:SF3">
        <property type="entry name" value="OS02G0208700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="288" mass="32279" checksum="E21C6E6BB224B79A" modified="2014-10-01" version="1">MELIPGLPNDVAIECLIRVPFSQISKAASVSKNWKAEIQLPEFRQRRKAAGFTQPLIAMTRADINLNEHIRDDDDGGARRLHHYLLKICDPERRFWYEVPSIPGFSKGVPMFCQVAGVGTNLVVIGGYDPVSWKTLNSVFIYDFLTATWRDGAAMPGGQRSFFGSASDGDHRILVAGGHDGNKNALASAMMYDVAKNEWVVLRDMARERDECKCIFHRGRFHVVGGYCTDRQGDFESSAEALELDDVDGWKWDELENIHEMDLALTKIEVPGGHSDTVHVQSCCYLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN98</accession>
    <name>A0A068UN98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030098001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN98"/>
    <dbReference type="Gramene" id="CDP09679">
        <property type="protein sequence ID" value="CDP09679"/>
        <property type="gene ID" value="GSCOC_T00030098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN98"/>
    <dbReference type="OMA" id="HENSECT"/>
    <dbReference type="OrthoDB" id="1683101at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28764" checksum="9A620368954BD946" modified="2014-10-01" version="1">MSSLVLYFHLVMQFDLSTSANTLTIFLGSTFLLTILGGLISDTYLNRLHTCVLFGILEVLGLLLLYIQAKSHKLQPDPCGKSSCVKGSEAVMFYCTIFLLALGAGGVKGSVAALGADQFDQKDPKEAKALASFFNSYQFSITVGSIIGVTIVVWVAMNRGWHWGFLISLIATSIGVVILALGKPFYRIQAQGASPLVKISQVIVAAIRNRNVPLPQDANELYEIEDNDAISHTSQFRYCIRIIIKLASLTLKFSNNLNFQTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNK6</accession>
    <name>A0A068UNK6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PI4-kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030593001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739126">
        <property type="protein sequence ID" value="CDP10031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNK6"/>
    <dbReference type="STRING" id="49390.A0A068UNK6"/>
    <dbReference type="Gramene" id="CDP10031">
        <property type="protein sequence ID" value="CDP10031"/>
        <property type="gene ID" value="GSCOC_T00030593001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNK6"/>
    <dbReference type="OMA" id="CKELPNC"/>
    <dbReference type="OrthoDB" id="1839860at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI4-kinase N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="257" mass="28631" checksum="F4D51FEEBE8B173F" modified="2014-10-01" version="1">MWFFSAATSIGGLDPKPVTTDLPASDSGVLSQNLHPKNESFNEVLLTKFVRLLQQFVNTAEKGGEVDKSSFRDTCSQATALLLSNLESDMKSNIESFSQLLRLLCWCPAYISTPDAMETDVFVWTWLVSAAPQLGSLVLAELVDAWLWTIDTKRGLFASEMRCAGPAAKLRPHLSPGEPELQPEKDPVEQIMAHRIWLGYFIDRFEVCCTFEPAHLCAGSTGILGIKSCVLSYLYRWLRVWLSCVCCCTFLSLLTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US19</accession>
    <name>A0A068US19_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CDI-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033134001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739135">
        <property type="protein sequence ID" value="CDP11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068US19"/>
    <dbReference type="FunCoup" id="A0A068US19">
        <property type="interactions" value="927"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068US19"/>
    <dbReference type="Gramene" id="CDP11102">
        <property type="protein sequence ID" value="CDP11102"/>
        <property type="gene ID" value="GSCOC_T00033134001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US19"/>
    <dbReference type="OMA" id="CEYAREW"/>
    <dbReference type="OrthoDB" id="590152at2759"/>
    <dbReference type="PhylomeDB" id="A0A068US19"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35105">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35105:SF7">
        <property type="entry name" value="PROTEIN CDI-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32577" checksum="D57917149BD5AAE2" modified="2014-10-01" version="1">MSTLVANFNLGGEEVKKPLDSKVESDMVSKNLSNGNLDSSQNSLQSKPFRIFIGYDPREDIAYEVCKYSLLKRSSIPIEITPIKQSEIREKGLYWRERGKLESTEFSFSRFLTPLLANYEGWAMFVDCDFLYLGDIKELTDLVDDKYAIMCVQHDYTPKETIKMDGSVQTVYPRKNWSSMVLYNCGHPKNKVLTPEVVNSESGAFLHRFQWLEDDDIGEIPFVWNFLVGHNRVVEGDPSTFPRAIHYTSGGPWFEAWKDCEFGDLWLKELEEYKEAKEKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT53</accession>
    <name>A0A068UT53_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00031670001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739131">
        <property type="protein sequence ID" value="CDP10798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UT53"/>
    <dbReference type="STRING" id="49390.A0A068UT53"/>
    <dbReference type="Gramene" id="CDP10798">
        <property type="protein sequence ID" value="CDP10798"/>
        <property type="gene ID" value="GSCOC_T00031670001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT53"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF318">
        <property type="entry name" value="BETA-GLUCOSIDASE 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18296" checksum="51DB0BA3BB139898" modified="2014-10-01" version="1">MWKNAKPQGGKVKFALFFFRVDCHKFNLIDRDDFRDFAELCFKEFGDRVKSWSTFNEPWSFSTGGYDSTTFIGCPAGDSSTEPYLVAHHIILSHAAAAKLYREKYKPSQKGQIGIVLVTNWMKGKLSLYPPWFTLFLHNPPMVSKAIHNPLMVWIKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTD5</accession>
    <name>A0A068UTD5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00035019001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glutamate-gated receptor that probably acts as non-selective cation channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTD5"/>
    <dbReference type="FunCoup" id="A0A068UTD5">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTD5"/>
    <dbReference type="Gramene" id="CDP11785">
        <property type="protein sequence ID" value="CDP11785"/>
        <property type="gene ID" value="GSCOC_T00035019001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTD5"/>
    <dbReference type="OMA" id="SMTCLGD"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13686">
        <property type="entry name" value="GluR_Plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19990">
        <property type="entry name" value="PBP1_GABAb_receptor_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000037">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000054">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000175">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000081">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044440">
        <property type="entry name" value="GABAb_receptor_plant_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017103">
        <property type="entry name" value="Iontropic_Glu_rcpt_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037090">
        <property type="entry name" value="Iontro_Glu-like_rcpt_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657961" description="Glutamate receptor" evidence="17">
        <location>
            <begin position="27"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="476"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="845"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="739"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037090-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP11785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="909" mass="101741" checksum="9AE4DE9A1E767E0D" modified="2014-10-01" version="1">MELMFCLKRAFLVWVSCLWVPMVVVGQGANDSSAARPKEVKVGALFTLNSYIGKSAKPAILAAFDEINSNPSILKGTKLKLILHDTNCSEFLGTVEALQLIEDEVVAAIGPQSSGIAHVISHVVNELHVPLLSFGATDPTLSALQYPYFLRTTMSDYFQMYAIADMLEYFGWREIIAIFVDDDYGRSGISVLGDALAKNRAKISYKAAFSPNAPRSDIKDLLVGVNLMESRVFVVHVNPDSGLTIFSVAKTLGMMSAGYVWITTDWLPSVLDSMDSVDSDTMDLIQGVVSLRHHTPESDLKRSFSSKWKNLKDKETPNFNSYALYAYDSVWLIARALDVFFNEGGNITFSEDPSLHDTNGSALYLNSLHIFDQGPKFLKILLSMNFTGLTGLIQFDSEKNLIRPSYDILNIGGTGIRTIGYWSNYSHLSTVAPEILYTKPPNISASNQHLYSVIWPGEMTAQPKGWVFPNNGKPLRIAVPNRVTFKEFVSKDNGPSGAKGYCIDVFEAAINLLPYPVPHTYILYGDGNRNPEFNNIVFDVSQNKYDATVGDITITTNRTRIVDFTQPYMESGLVVVAPVREVKSSPWSFLKPFTWQMWCVTAAFFLFVGAVVWILEHRMNPEFRGPPRQQLVTIFWFSFSTMFFAHRENTVSTLGRLVLILWLFVVLIINSSYTASLTSILTVQQLTSRVQGIDKSRLRTMKTQDDYVAALQKGPNNGGVAAIVDELPYIELFLVNTKCTFRTVGQEFTKSGWGFAFQRDSPLAVDLSTAILQLSESGDLQRIHDKWLSSDACSSQTNPVDENRLSLDSFWGLFLVCGIACSIGLLLFFWRIWQQYRLVNKDDEEQAARERELPPDDGSRRSTQRATSFKSILDRREAEIKEMLKLKRKSSDQKRAPSQSSDGLPVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTG5</accession>
    <name>A0A068UTG5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00033959001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739141">
        <property type="protein sequence ID" value="CDP11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTG5"/>
    <dbReference type="STRING" id="49390.A0A068UTG5"/>
    <dbReference type="Gramene" id="CDP11602">
        <property type="protein sequence ID" value="CDP11602"/>
        <property type="gene ID" value="GSCOC_T00033959001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTG5"/>
    <dbReference type="OMA" id="HEPRLEN"/>
    <dbReference type="OrthoDB" id="1515643at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTG5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042160">
        <property type="entry name" value="HD-Zip_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654:SF9">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HDG10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45654">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN MERISTEM L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="161" mass="19007" checksum="D1BBAA77C07D5B1F" modified="2014-10-01" version="1">MDPVNGGIGSDDEVSSNNSPKHKNQYHRNSPDLVAQLEEYFKDNPHPNENERKELGRELRVDPKRIKFWFQNKRNQVKAQIARAENHLLREENQKIYLENMMMRERMRCTVCSTCAGLATATKQDDDRKLILRQLLVENAQLKEEVYFMHSSFLRIYILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTI4</accession>
    <name>A0A068UTI4_COFCA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033885001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739140">
        <property type="protein sequence ID" value="CDP11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTI4"/>
    <dbReference type="Gramene" id="CDP11564">
        <property type="protein sequence ID" value="CDP11564"/>
        <property type="gene ID" value="GSCOC_T00033885001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTI4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="399" mass="43653" checksum="AC1A66B3FE7C0B3F" modified="2014-10-01" version="1">MPCGTADDRQGSAGSPISIPIEGSQCTSNCDKFSESLISSVPINNVEAGGKTISVSAVTLDPSPRLKDLMDDKMQNEGPAMVILDQECKGSETASVVSLFKRSPGASTPTEEHVRKLVKDPVVNDATPSCPLTTKTETNPVVNNAMPSCPQTADTETNKDPEQLFPEIEQNKPTQGQKVSAKSTAMNTVEPCLEQTRSICFVPAFPLDGKVMTPVVDHHPTMTQQSNNESFLRRELDSLRCDLVRTSTRGALLEDELKALKNKMEHDAFVTPSKISSMEKKLDLMFEHHAKQSGGAQVEPAQEKIISSNKSKMSADDVTRLLEPIKRAGWTEALEEVKAKHLPHLNLIEFPMYDPGSRLKAGLIAKRICESGIQIDHLVSLEATEKDQARETQCNIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTM4</accession>
    <name>A0A068UTM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00034238001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
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        <property type="protein sequence ID" value="CDP11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP11751">
        <property type="protein sequence ID" value="CDP11751"/>
        <property type="gene ID" value="GSCOC_T00034238001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTM4"/>
    <dbReference type="OMA" id="NIVHISH"/>
    <dbReference type="PhylomeDB" id="A0A068UTM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF42">
        <property type="entry name" value="NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="78"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="318"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="432"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="100196" checksum="1C72C5B7713272E1" modified="2014-10-01" version="1">MEASVGILIDTLNSMIQKEFGLLCGVATDMQKLSRLLSATKAVLEDAEQKQFTDKAIQQWLQELNIVRILTKERDRVDQNVSVLPIVGVGGLGKTTLAQLVFNDQRITQHFDLKLWVWVSEDFDVKRIIKVLICSIQRTLTEELESLSLERKLQGLLRGKRYLVVLDDVWNKNPEEWEKLKSVLECGSRGSSIVTTTRMEKVATIMGTLQTHYLSSLSENLYWSLFRQRAFGPQEAEEYPNLVVIGKEIVKKCGGVPLAAKALGGFLRFKREENEWNYVKCSEIWNLPEDEVHVLPALRSSYLNLPVELRGCFAYCAVFPKGSEIEKEEVIHLWMANGLISSNGTMEVEDVGDAVLTELYYRSLFQEVKEDEFGNALTFKMHDLVHDLARSVMEAKHGGTESNRTMMLGVPYDQLTVAFPITITGTDQFSSLLSQCGSLRALIIRSTWWGEMFTELPHAISKLKHLRHVNLSGSDVVELPNSICDLWNLQILNLNDCDKLRSLPKGMIFLRNLRHLCLQGCWNLTHMPSGIGKMTCLRMLSMVVLSGKNGFQLSEMRDLNMLRGILIIRHLERIETKKDAKEACLIKKQSLRKLHLCWDSERTVQRYNDEEVLEALKPCPNLQFLHIEGFNSSSFPSWMSTVTKVTVDGSAAEYIVGARESTAADARSPSLKQLELMNMPNLKGMLGREVQGTTSTPRAFSQLQSLSFFNCPTLTLQLPRMPSLKELYVENCPNMAWASISNLTSLNSLKIKNIEGLSCLPKEMLQNLSLLESLQIRHVRALRALPRSLASLTALKELIIWGCPMLKSLPEEVKHHLTSLQHLTLHKCPKLETLPSSIQMMTTLQSLTIGACDLLEPRCEEGGEEWHKIKHIHKLSKEINIFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTP7</accession>
    <name>A0A068UTP7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035227001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTP7"/>
    <dbReference type="STRING" id="49390.A0A068UTP7"/>
    <dbReference type="Gramene" id="CDP11920">
        <property type="protein sequence ID" value="CDP11920"/>
        <property type="gene ID" value="GSCOC_T00035227001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTP7"/>
    <dbReference type="OMA" id="QAMDINT"/>
    <dbReference type="OrthoDB" id="75710at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045274">
        <property type="entry name" value="WAK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005:SF466">
        <property type="entry name" value="NON-FUNCTIONAL PSEUDOKINASE ZED1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="296" mass="33091" checksum="00954885DEFFCFE2" modified="2014-10-01" version="1">MIPLFRKRQKEDETSPFFFENGGALLEELMASFGGRYENPIRTFSLKELLGATTDFTERVVLRDSGCMFRGFLGEKQILVKRFCAYEDISPHVFRGPIRDIAVSSQMSHVKNILKLRGCCLELKFPALVYECSATKLLADLLYHPDVEKLLSWKSRMQIAKGIANAIAYLHNAFATPIVYRNLKPSTVILDKDGTPKLFDFSLSVKLPPGKSQVEDVVMGTWGFVDPEHLESGIVTEKTDVYSIGVLLLVLLTGKEAMCKNHVGKKNLDGRKCNARQAIASFLGPCNDVYSDEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UU45</accession>
    <name>A0A068UU45_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034234001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UU45"/>
    <dbReference type="STRING" id="49390.A0A068UU45"/>
    <dbReference type="Gramene" id="CDP11749">
        <property type="protein sequence ID" value="CDP11749"/>
        <property type="gene ID" value="GSCOC_T00034234001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UU45"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UU45"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027728">
        <property type="entry name" value="Topless_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083:SF5">
        <property type="entry name" value="PROTEIN TOPLESS-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="24648" checksum="87A1E23FFF744EE5" modified="2014-10-01" version="1">MGGRPTNVAGGGSLFIYIVKTKLKGHHKQSTGLAFSQNLTVLLCIWNIDGWEKKKMKAIQAPPGHTSPLIGETIVQFHNDQCHLLVSHESQIAVYDTQLECLNSWYPRDALSAPISSATYSCNGLSVYTGCLDGAIGIFDADSLRLRCRVAPSAYMSSSIVSSSSAFPMVIAAHPSNPSQIALGMSDGAVLVIEPSDTEPKWGSLSSQDNGTLPTTPSSSALSSQPSKTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUB3</accession>
    <name>A0A068UUB3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Equilibrative nucleotide transporter 3-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00035183001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUB3"/>
    <dbReference type="STRING" id="49390.A0A068UUB3"/>
    <dbReference type="Gramene" id="CDP11897">
        <property type="protein sequence ID" value="CDP11897"/>
        <property type="gene ID" value="GSCOC_T00035183001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUB3"/>
    <dbReference type="OMA" id="DVSMLKI"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUB3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF30">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOTIDE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42446" checksum="96736E45C931B694" modified="2014-10-01" version="1">MAVCWLLGNGCLFSWNSMLTIEDYYVYLFPSYHPSRVLTLVYQPFALGTLAVLAYNEAKIDTRKRNLFGYSLFFVSTLLVLVLDLATSGRGGIGTFIGICVVSGAFGIADAHVQGGMVGDLSFMLPEFIQSFLAGLAASGALTSALRLITKAAFENSKDGLRKGAILFFAVSTFFELLCVLLYAFVFPKLPIVKYYRSKAASEGSKTVSADLAAGGIHRQPEQVGQDPKQPERLSNKQLLVQNIDYALDMFLIYVLTLSIFPGFLSEDTGSHSLGSWYALVLIAMYNVWDLIGRCIPLWKRIKLESRRGLTTAILSRFLLIPAFYFTAKYGDQGWMITLTSFLGLSNGYLTGPEQNALGNILVLFLLGGISAGVTLDWLWLIGKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUW7</accession>
    <name>A0A068UUW7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00033680001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUW7"/>
    <dbReference type="FunCoup" id="A0A068UUW7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUW7"/>
    <dbReference type="Gramene" id="CDP11428">
        <property type="protein sequence ID" value="CDP11428"/>
        <property type="gene ID" value="GSCOC_T00033680001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUW7"/>
    <dbReference type="OMA" id="VKPRCRC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000745">
        <property type="entry name" value="Phytosulfokine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052059">
        <property type="entry name" value="CR_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47973">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="92"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="387" mass="43051" checksum="DAF14F7FE10F7D7E" modified="2014-10-01" version="1">MNPTLQAVLAAMASFFAVTVLFGVLMVICRTSSKRQRPNPPRSRVRTLDTRPKAVPTNKPEFSSITIGETTTFDSSLNPVSMAELLQATANFSPELIVGDGSFGLVYKAKLSSGVVVAVKKLDADAFQGFREFQAEMETVGKIHHPNIVKILGYCSTGSERILVYEYIERGSLDQWLYDTSCPSEDTDDVDVEHSVFRLPLSWVTRIKIIRGIARGLAYMHNLDTPIIHRDIKASNVLLDANFEAHIADFGLARSIEGSHSHVSTQVAGTMGYMPPEYLGGATTATMMGDVYSFGVLMLEIVTGRRPSLPFPWEDRKEIRLMEWVNAMVAQKRYMEMVDGNILKDELKENEVIEVFRIAKMCATEYGKTRPAIKEVAQMLDGVSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV94</accession>
    <name>A0A068UV94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035595001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV94"/>
    <dbReference type="FunCoup" id="A0A068UV94">
        <property type="interactions" value="3258"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UV94"/>
    <dbReference type="Gramene" id="CDP12187">
        <property type="protein sequence ID" value="CDP12187"/>
        <property type="gene ID" value="GSCOC_T00035595001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV94"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV94"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="79"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="267" mass="30805" checksum="FFE56AD35B13CC00" modified="2014-10-01" version="1">MDPKFIEVSQLFDRFKAAFVRNDLDTCANLLSQLKVSLTGFKSLPPLFENTPNAIRELSLARDIYEHAVVLSVKNEDQDAFERDFFQLKPYYTDARGRLLPSPQEYPILGLNLLRLLVQNRIAEFHTELELLSPSALENPCIRHAIELEQSFMEGAYNRVLSARQTVPHETYVYFMDLLAKTVRDEIAGCSEKAYDSLSVKDARQMLLFSSDKEVLEYIREDHPDWEIKNGLVIFQRAKESAPCKEIPSLQLINQTLSYARELERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVN3</accession>
    <name>A0A068UVN3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box/kelch-repeat protein SKIP11-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035848001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVN3"/>
    <dbReference type="STRING" id="49390.A0A068UVN3"/>
    <dbReference type="Gramene" id="CDP12357">
        <property type="protein sequence ID" value="CDP12357"/>
        <property type="gene ID" value="GSCOC_T00035848001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVN3"/>
    <dbReference type="PhylomeDB" id="A0A068UVN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052439">
        <property type="entry name" value="F-box/Kelch-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46122:SF9">
        <property type="entry name" value="F-BOX_KELCH-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46122">
        <property type="entry name" value="GALACTOSE OXIDASE/KELCH REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655144" description="F-box/kelch-repeat protein SKIP11-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32176" checksum="38263AE02B44C477" modified="2014-10-01" version="1">MAELFRYSFASLFSRLFLTLSAIILERPSFLVSRDLPSACEEESKWVFNTYSTIENLKRKGLRERTQSYSIPRERLDAPREGTQSESTLRRGRDWKSWCTLPTMHKPRKLCSGVFIDGKFYVIGGIGIGNPIASDGANLKVLTCGEVYDLRTGTWSEIPDLYPQCAREGTNDFPAIARAPPLLVMVKNALYTTYCDEKEVWKYDKQRNVWITIGRLPEQATSMNGWGMAFKACGNQLMIISGPRALNGGYIEINAWKPNKGPLEWTLLGTKHLGSFVYNCVAMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVX2</accession>
    <name>A0A068UVX2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00035955001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739148">
        <property type="protein sequence ID" value="CDP12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVX2"/>
    <dbReference type="FunCoup" id="A0A068UVX2">
        <property type="interactions" value="3158"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVX2"/>
    <dbReference type="Gramene" id="CDP12424">
        <property type="protein sequence ID" value="CDP12424"/>
        <property type="gene ID" value="GSCOC_T00035955001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVX2"/>
    <dbReference type="OMA" id="VIWPKVI"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVX2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000002">
        <property type="entry name" value="isoamyl acetate-hydrolyzing esterase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF36">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27641" checksum="E3C1E54CA365CBAB" modified="2014-10-01" version="1">MRPQIVLFGDSITEQSYRSGGWGAALADTYSRKADIVNRGFGGYNTRWALFLLHHLFPLGSATPPVAVTVFFGANDAALLGRTSERQHVPVDEYKENLRRMVQHLKECCSTMFIVLITSPPVDEEGRKEYARALYGEKAMKLPERTNEIAGLYAEKCVELARELDLPSINLWSKMQETDGWQKKFLRDGLHLTEDGNAVVYQEVFRVFSEAWLPASKMPYDFPHHSEIDPENPGKAFQQQCLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXR7</accession>
    <name>A0A068UXR7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00037882001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXR7"/>
    <dbReference type="Gramene" id="CDP13097">
        <property type="protein sequence ID" value="CDP13097"/>
        <property type="gene ID" value="GSCOC_T00037882001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXR7"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXR7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="78" mass="8518" checksum="4FD86586BD7F27CC" modified="2014-10-01" version="1">MEQILHTKGGEDEESYAKNSTFQVMFMNVNHALNRSIQGFCQASLAEAECIRVADLGCASGPSRANYILLPCGLAFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXV2</accession>
    <name>A0A068UXV2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00036058001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739150">
        <property type="protein sequence ID" value="CDP12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXV2"/>
    <dbReference type="STRING" id="49390.A0A068UXV2"/>
    <dbReference type="Gramene" id="CDP12473">
        <property type="protein sequence ID" value="CDP12473"/>
        <property type="gene ID" value="GSCOC_T00036058001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXV2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXV2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF4">
        <property type="entry name" value="OS09G0441700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="248" mass="28388" checksum="E48D4402F6086637" modified="2014-10-01" version="1">MSRKYIKIFGFSHSYFSGHHTWPIVGNLPELCKKRLTFLWIESIIQKLATDIGCIRLGNVLVTVVKSLELALEFLVKKDNVFLSRPLTMATEYVSRGFLGMAVSPWGSHSNKDCSVVNLRFALRHYSVNILRGILFSRRFFGRGGGDEEAEHLDAVFTILRCMYVFTVSDYLPSLRIIDVAGHQKTIKDAMSVFNKYHDPIIEKRIEQRRNGKKHEPENLLDVMITLKDERGRPLLSPDEIKAQCTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY82</accession>
    <name>A0A068UY82_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe-S metabolism associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038120001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY82"/>
    <dbReference type="STRING" id="49390.A0A068UY82"/>
    <dbReference type="Gramene" id="CDP13242">
        <property type="protein sequence ID" value="CDP13242"/>
        <property type="gene ID" value="GSCOC_T00038120001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY82"/>
    <dbReference type="OMA" id="LACEFKS"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY82"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597:SF5">
        <property type="entry name" value="SUFE-LIKE PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="SULFUR ACCEPTOR PROTEIN CSDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S metabolism associated" evidence="2">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="285" mass="32155" checksum="15BC4AC7BF864475" modified="2014-10-01" version="1">MQSLTQNLSFLSPLFSQVSGSPEPKKIQLKSSFFKNPIFFTSHKSVHSPDKPISTGVFPKNPIFFTSPKCYHNPDKPISRNPRNSSVSCITAHEIPLQPLTVPEKVHCLACEFKSLPEPIDRVKRLLHYATLLPPFDESGRVEENRVKGCTTMVWLQVEMDGNRLMRYKVDSDSEITKGFCSCLIWLFDGAIPEEVLSVKTDDLAEMNVGMPSKGHSRVNTWHNILISIQKKTKNFVEVKDKDRSLTEFPPLVGSTDGFSVYGNYKEAQYMQESRQAGNEVEGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYF9</accession>
    <name>A0A068UYF9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036380001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYF9"/>
    <dbReference type="STRING" id="49390.A0A068UYF9"/>
    <dbReference type="Gramene" id="CDP12663">
        <property type="protein sequence ID" value="CDP12663"/>
        <property type="gene ID" value="GSCOC_T00036380001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYF9"/>
    <dbReference type="OMA" id="INWSEPE"/>
    <dbReference type="OrthoDB" id="1929779at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYF9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949:SF15">
        <property type="entry name" value="ENDOCHITINASE A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949">
        <property type="entry name" value="GASTRIC MUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="496" mass="52451" checksum="CB12BD15280A4A32" modified="2014-10-01" version="1">MQASVQCRPQDRSLGMVMKEIEGDLATFLEMRKREKERNGLFLIENNDGFDHSAASNPDNSVVSDAIFIETTQTTPADNFFAAVSNKSDYDWLVASPDTPSLPLPELEPENLPDEPSSANTTSAQLITSTSKHSSASRNKRSSLSEGQKPTASRSATPTRKSGLLSASKPLRSSTPTSRGVAASAKPVVPIVRSSTPTRATARSSTPTLSLRSASKSESRSARPTCKASTPSSATSMSAAGRSSSVTKTVPTTVKSSKTSCGTTPPVKSQPKKTAEKAVFSSNTPPNLRMAVPKRPSSASRGRLTASSYLLSSSDSIAGRPRQKSCSPSRGRVNDGAFNHEITIFPKSRGYSNCNDSVNPVLIGTKMVERVVNMRKLAPSKHNNYESQDNSSGKPSLSIGNSGFGRSLSKKSLDMAIRHMDIRGISGNLKTIVTSLPASKSGSTKSRTTSLSDSPLATCSTASSEPSVNNVANVLDGSDIDVNDIGCERESLPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYZ8</accession>
    <name>A0A068UYZ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00037545001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYZ8"/>
    <dbReference type="STRING" id="49390.A0A068UYZ8"/>
    <dbReference type="Gramene" id="CDP12868">
        <property type="protein sequence ID" value="CDP12868"/>
        <property type="gene ID" value="GSCOC_T00037545001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYZ8"/>
    <dbReference type="OMA" id="RSTANLW"/>
    <dbReference type="OrthoDB" id="1842836at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYZ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF17">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="217" mass="24868" checksum="C0D50AFBF7CD4E2B" modified="2014-10-01" version="1">MLNQSLFEDQDMSSQLGFFAFSSNPYNLPFGCSQPSLKTLTAVAGSLAADTQTTLSESATQKQKEDVTSHFGEPPQLRSLQRSNANLWAWGEVNDCMNSKKNGGDNYLGVATIKMKKIKARRKVREPRFCFKTLSEVDVLDDGYKWRKYGQKVVKNTQHPRSYYRCTQDNCRVKKRVERLAEDPRMVITTYEGRHIHSPSQDEDDSQASSQMNNFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0Z7</accession>
    <name>A0A068V0Z7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040457001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of a SCF E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SCF-type E3 ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0Z7"/>
    <dbReference type="Gramene" id="CDP14197">
        <property type="protein sequence ID" value="CDP14197"/>
        <property type="gene ID" value="GSCOC_T00040457001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0Z7"/>
    <dbReference type="OMA" id="WFTEELP"/>
    <dbReference type="OrthoDB" id="1905685at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0Z7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF16">
        <property type="entry name" value="OS01G0800800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="214" mass="23391" checksum="9A9961BF2DEF04B2" modified="2014-10-01" version="1">MSEKSLKSSPRWSVLSLVANHLDPKTLIIASCVCKSWSICMSSDHLWKPICSTLYPIIFAIDVFNGNVCLSTTIKPGNQLVVDKSFLFRFDIGADLGNGHGDPSVAIEAMDNLRVTWNVVLGGLRSVFTMMDCKGKGSFVLGLEGWFSKELPHSGCCSSGDASGLVADLRLGLRKSGGKVMVEKISVGVLSILSWRYVCIDDALRYLQHFLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1U8</accession>
    <name>A0A068V1U8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00041060001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1U8"/>
    <dbReference type="FunCoup" id="A0A068V1U8">
        <property type="interactions" value="2792"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP14542">
        <property type="protein sequence ID" value="CDP14542"/>
        <property type="gene ID" value="GSCOC_T00041060001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1U8"/>
    <dbReference type="OMA" id="NPLHFQW"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1U8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12429">
        <property type="entry name" value="RRM_DNAJC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034254">
        <property type="entry name" value="DNAJC17_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45098">
        <property type="entry name" value="DNAJ DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45098:SF1">
        <property type="entry name" value="DNAJ DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP14542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33225" checksum="3D44A4DB2730EC01" modified="2014-10-01" version="1">MDIEIDHYVVLGLPSEEEGARLSEKEISKAYRLKALELHPDKRPDDPNAHANFQKLKTSYEILKDEKARKLFDDLVRIRKEKIQRQSRQDTKRRKMMSDLEERERAAFAVDPELRAREEEDRIARKLKDEIARIRSMFTNKASSAMPTPTPQKDTSKSPQRNTGDGGKTVDKGKVLKVSWEKVGEDYSAHRLREIFQGFGEVEDVVIKSSKKKGSALVVMASNDAAVAAVGNVLGSLSNPLLVLPLKPAQTTPVFSCAQDGVEPDEPKLNNLVGAGYQAFEDSVLEKLRKAAQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2X0</accession>
    <name>A0A068V2X0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042406001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739176">
        <property type="protein sequence ID" value="CDP14917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2X0"/>
    <dbReference type="FunCoup" id="A0A068V2X0">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2X0"/>
    <dbReference type="Gramene" id="CDP14917">
        <property type="protein sequence ID" value="CDP14917"/>
        <property type="gene ID" value="GSCOC_T00042406001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2X0"/>
    <dbReference type="OMA" id="DIKSSCP"/>
    <dbReference type="OrthoDB" id="657513at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2X0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34778">
        <property type="entry name" value="OS02G0580700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34778:SF2">
        <property type="entry name" value="OS02G0580700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="500" mass="56240" checksum="5628CC76AC63A9B1" modified="2014-10-01" version="1">MAADEKLGALKKAYADIILNTAKEAAARIMASERKAQRFQRELQMAKEEALRMLLRLKQMMDSKISDAELTSLSQQKKIDELEAQLQEAEDIVKDLREELREVNIELERVRNSKEKLLDDWHAVAQRGISEENESHYSQSNALPPNQSDLGHVAAAELRSMHEFQKNESFKFYSGIPHVGNLYLGCPDLPSIILRSKEPELYRNGCTQRIRASEGNFSNMLSGKVHKRKDEISTLEDLGGKQIFSVPNCSLGNLSNVEKKLEADSQLGRWNPAPIFCVKKKRATRYRKRAITSSGCFPDQFPRPNQVPDVSCAATHLISVRSDVHFEENKSKMVSRLSSDEPEPGLEEDCAETSENDIELGNSAAVHRPVNENEGTEKLVLKDSAGSSVATDGETDLQKSNITLPIYEPNVPTVVDRVGNQPIQERIIKYTFQRKRKRDSLSKSNGVVSFESDTSKRRTLGEESDPVEQEKSNLVTESSRHCGRLAHIAHQLISLSESKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V396</accession>
    <name>A0A068V396_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00042583001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V396"/>
    <dbReference type="FunCoup" id="A0A068V396">
        <property type="interactions" value="3491"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V396"/>
    <dbReference type="Gramene" id="CDP15042">
        <property type="protein sequence ID" value="CDP15042"/>
        <property type="gene ID" value="GSCOC_T00042583001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V396"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V396"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="98"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="412"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP15042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="563" mass="63140" checksum="2DC0AA6DB683C6E6" modified="2014-10-01" version="1">MATAAVAGPRKVPRPGRGGVISHNLTEEEARVKAIAEIVSNMVDLSRKGENVDLNALKSAACRKYGLSRAPKLVEMIAALPESERESLLPKLRAKPVRTASGIAVVAVMSKPHRCPHIATTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYVQARSRIDQLKRLGHSVDKVEFILMGGTFMSLPSDYRDYFIRNLHDALSGHTSANVEEAVAYSEHSAVKCIGMTIETRPDYCLGPHLRQMLSYGCTRLEIGVQSTYEDVARDTNRGHTVAAVADCFSLAKDAGFKVVAHMMPDLPNVGVERDMESFKEFFESPLFRADGLKIYPTLVIRGTGLYELWKTGRYRNYPPEQLVDIVARILAMVPPWTRVYRVQRDIPMPLVTSGVEKGNLRELALARMEDLGLKCRDVRTREAGIQDIHNKIKPEEVELVRRDYTANEGWETFLSYEDTRQDILVGLLRLRKCGRNVTCPELTGKCSIVRELHVYGTAVPVHGRDADKLQHQGYGTLLMEEAERIAVREHRSKKIAVISGVGTRHYYRKLGYELEGPYMVKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3N4</accession>
    <name>A0A068V3N4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042892001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068V3N4"/>
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        <property type="protein sequence ID" value="CDP15246"/>
        <property type="gene ID" value="GSCOC_T00042892001"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="A0A068V3N4"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
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            <end position="589"/>
        </location>
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            <begin position="602"/>
            <end position="640"/>
        </location>
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        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="70203" checksum="3DB1E84D67205FF2" modified="2014-10-01" version="1">MGSLGGEIARKKAMWLSPKVIGVSPSERWGHSACYSNGLVYIFGGCCGGMHFSDVLVLNLETMDWSTLVTKGQGPGPRDSHSAVIVGYKMIVFGGTNGSKKVNDLYVLDLRSKEWTYPECKGTPPSPRESHTATLVGDEKLLIFGGSGEGEANYLNDLHVLDLKTMRWASPEVKGNVPVPRDSHSAVAISNRLILYGGDSGDRYQGDVDMLDMDTLTWSRMDIQGSSPGARAGHSSVYVIGGVAHKQYYNDVWILDIVSCSWSQLDICGQKPRGRFSHTAVVTNLDTVTVFGGCGEDEHPLNELLILQLGVDYANGLYKMPFYKTSGNQCNQERKRFLREAENGLKRTVLMATSETLFIKDAEELKPLPKKSFCMDTDAFQMKKRRTNNLKMYGIASDAEEHSLSLSQSSSPSQSDQEQTPIKKCTEVSPQALPIFKQYCATPASLQSNHVPLNQPNPRIITPRTRQELHVFGEHPDQSKLHNLQAVNFRKHELHFSTDGQRSLEPGQFQNLIGAEVRGNVDGEFDSGYLMTATVNGRTFRGVLFAPGPYLVPRGVNLGQRPSSLRNQVNSSASHSSLGALRQSQQPTKQYAPEFQLAEVRRPISAVRSPPSSNTEPNLKSELQGVVLSLGGPGSGNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3W1</accession>
    <name>A0A068V3W1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication factor A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041096001</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3W1"/>
    <dbReference type="Gramene" id="CDP14568">
        <property type="protein sequence ID" value="CDP14568"/>
        <property type="gene ID" value="GSCOC_T00041096001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3W1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655526" description="Replication factor A C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22093" checksum="202F0F9623672F19" modified="2014-10-01" version="1">MCFCCILFSRCSCSLSFFCHFFSSFLFLFSFCPHQCCSVTNRRALSVWILCRPFAFPPPSSRAFSFFLSGELRSSLGAVSVVGCWFRILCRSPEFSSSSFAVIEASHLKTTYADHASRMYRRFVFADSHGVKVSAVAFDDNVARIIELKEEDEDLRSWYWNPPERVVGIISISGFGTLVSSLRFLEFILVDRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4L2</accession>
    <name>A0A068V4L2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00042263001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4L2"/>
    <dbReference type="STRING" id="49390.A0A068V4L2"/>
    <dbReference type="Gramene" id="CDP14803">
        <property type="protein sequence ID" value="CDP14803"/>
        <property type="gene ID" value="GSCOC_T00042263001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4L2"/>
    <dbReference type="OMA" id="REMNHES"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4L2"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF34">
        <property type="entry name" value="O-ACYLTRANSFERASE WSD1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP14803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="308" mass="34452" checksum="4FDF4EE075A276C0" modified="2014-10-01" version="1">MSHEQFSAKLGAQCQMSMIDNNGLGPPGGDPIQISGKQIAGEDGQKKWKRVEVNVNEHVNFPKFPQGMSPDYYDDCVSNYLSKLGMEDFPPERPLWEIHVMNYPTTNAASNIVFKLHHALGDGYSLVGALLSCLKRSDNPSLPLTFPSGQSKTKFKNASTTFLPDVLSRAFNTIYYFGYGVLKGFLLRDDHTPIPSDDEGVLFRPLTMTTMEFSLDQFKQIKAKLQVTINDVIMGIIMFGTRIYMREMNHESSEANCTAVVLLNTRYAAGYKSVSEMIKPNAEMPWGNRFAFLPLPIPKLTATESSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V503</accession>
    <name>A0A068V503_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00015696001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739188">
        <property type="protein sequence ID" value="CDP15701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V503"/>
    <dbReference type="Gramene" id="CDP15701">
        <property type="protein sequence ID" value="CDP15701"/>
        <property type="gene ID" value="GSCOC_T00015696001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V503"/>
    <dbReference type="OrthoDB" id="1399306at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP15701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="190" mass="22540" checksum="01C524E41937EB8B" modified="2014-10-01" version="1">MEQNYNFNPSFIKLLMEDDFTREIRIPCSFVRNFKEKLPSRCTIESEAKNSVRNSWPVRIRKKGKTTFRVKPYGADCCPKKFNVYNSSSSSNDGIRPSKVHPAKKKVYTKYQIDRDNFRSNKFKKLRKTRKSGVGKQVLEIESEEGEDVETNERDGYFHLNAENPYFILRLKRHHMRRLVSKQQIFPHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6I8</accession>
    <name>A0A068V6I8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00015376001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6I8"/>
    <dbReference type="Gramene" id="CDP15518">
        <property type="protein sequence ID" value="CDP15518"/>
        <property type="gene ID" value="GSCOC_T00015376001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6I8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="70" mass="8091" checksum="45C2E56391418092" modified="2014-10-01" version="1">MTSDFASTETVWCYRLTLFILPFFPYKNPNILLACSTYIVTKRGCIHTQEIMRYKTTSTGAFATCCRINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7D4</accession>
    <name>A0A068V7D4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00018396001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739210">
        <property type="protein sequence ID" value="CDP16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7D4"/>
    <dbReference type="STRING" id="49390.A0A068V7D4"/>
    <dbReference type="Gramene" id="CDP16467">
        <property type="protein sequence ID" value="CDP16467"/>
        <property type="gene ID" value="GSCOC_T00018396001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7D4"/>
    <dbReference type="OMA" id="IFCEEIN"/>
    <dbReference type="OrthoDB" id="1864232at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7D4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="186" mass="20784" checksum="A0CB19F0001031F2" modified="2014-10-01" version="1">MASFFIYTISISYLLIMLPMFICISDQAFSEDISEAIAMKRMMKTSHLHFYFHDIVSGKNPSAMKVIGTEIMSFGTTFIIDDALTQGQEPTSKIVGRAQGMYAVAAQNDLALLMVINYSFTDGKFNGSSISILGRNHVFDDIREMPIVGGTGLFRFARGYALAHTIWFDIKTGDATVEYNVFVQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V860</accession>
    <name>A0A068V860_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00004813001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739225">
        <property type="protein sequence ID" value="CDP16980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V860"/>
    <dbReference type="FunCoup" id="A0A068V860">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V860"/>
    <dbReference type="Gramene" id="CDP16980">
        <property type="protein sequence ID" value="CDP16980"/>
        <property type="gene ID" value="GSCOC_T00004813001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V860"/>
    <dbReference type="OMA" id="HISAMID"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V860"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF62">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 81, SUBFAMILY D, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP16980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23106" checksum="2894AA6940320914" modified="2014-10-01" version="1">MIIIRNQRDYTDQIIKGIILVIYYWYVVLTARTDTSSMTIEWGLSLLLNYPEVLEKARTKLDAQVGIDRLVDEHDLSNLPYVHNISSETLRLYPAALMLVPHESSDDCKIGGYNIPRGTILLVNAWAVHKDPNIWDDPTSFKPERFEGFWLQPSKLIPFVMGRRSYPGSGLAQRVVGLALGSLIQSFDWKRIGEEKIDLAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V905</accession>
    <name>A0A068V905_COFCA</name>
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        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00000675001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CDP17205"/>
        <property type="gene ID" value="GSCOC_T00000675001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V905"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V905"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
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    </dbReference>
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        <property type="entry name" value="Pre-PUA"/>
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        <property type="entry name" value="PUA-like_sf"/>
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    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
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    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP17205.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="181" mass="20105" checksum="A30E1E234D69E707" modified="2014-10-01" version="1">MFKKFTSEEVSGQNQVKASVQRKIRQSVAEEYPGLEPVLDDLLPKKSPLIVAKCPNHLNLVIVNNVPLFFNIRDGPYMPTLRLLHQYPNIMKKFQVDRGAIKFVLSGANIMCPGLTSPGGALDDDVEAESPVAIMAEGKQHALAIGFTKMSAKDIRSINKGIGVDNMHYLNDGLWKMERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V920</accession>
    <name>A0A068V920_COFCA</name>
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        <recommendedName>
            <fullName evidence="9">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Lopez L."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Lashermes P."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
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        </subcellularLocation>
    </comment>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1359"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1608" mass="171779" checksum="34C50F635BA1C5DD" modified="2014-10-01" version="1">MHGREQREGESHHRRIVVVRKSGCGGQHMRSVPLSTTRNSLADGGGDSSLISTVITIISSDSFCKDGRRISVGDCALFKPPQDSPPFIGIIRCLRPSKENNLQLGVNWLYRPAELKLGKGILPDAAPNEIFYSFHEDETPAASLLHPCKVAFLPKGVELPSGISSFVCRRVYDIDNKCLWWLTDQDYINERQEEVDKLLQKSRIEMDASFQSGNRSPKPTNNSVSTSQFKPSSDNVQSSATSLPTKGKKRERGDQASDPVKRERSLKLDDSDSGLYKSESFLKSEIAKMTEKGGVVDSESVEKLVLLMQPDKVDKKLDLISRSMLAGVVAATDKLDCLNQFVQLKGLTVFDEWLQDAHKGKIGDSSDKSAEDFLLVLLRALDKLPVNLLALQTCNIGRSVNHLRSHKNLEIQRKARGLVDTWKKRVEAEMNMIDANTGSTQATSWPSKSRIPEAHGGRSSGGSGDVALKSSVTQLSAAKTMSIKVSQVETAGKSASPSPGAIKSASSPASGKDSQPRITTGSTSDIPLSTREEKSSSSSQSHNYSQSFSGKEDARTSTAGSMSVNKISSGGSRHRKSVNGFPGTLVSGSQKETGSSRNSSIHRTTAQEKFSQSVAMGEKVFETPVVDGATPKLIVKLPNRGRSPAQSVSGGSFEDPSIMSSRASSPVVSDKHEPSERTKEKADAGRANVISDVNAESWQSNDFKDLHTGSDEGDGSPTAVPEEDRSRPPEDGTKVPEVPKTASSSSGNDLKSGKLHDASFSSMNALIESCVKYSEASTPVSIGDDVGMNLLASVAAGEMYKSDSLTPADSPQECSPPVEEISNGEDAKSKSSPQETLVRERCEPNDVDGDDLKRGKSASSWSKDGICLSKQASLHSTGDRKAAAASSEEILQATTDRYSEMNEKYDDILVSSSLSPTTKVAKDRDLDSGKQSSEEKGVEVKFSVLSSTEDVKPKAEVPSNPSMEIDCKKDSNEMSNNVVLTEQKPQSEELPATGSIKDLASENVDSCKVREADEDPGDSGVNQSDGATLDPKTNMISTSEDKNLDGLSSDATDQKTDCLKANSEKMEVAEPHAFGTCALKEEPTVGSKEVVGDVDFKEAKKSDAEVAELEERVSTVVGATSLTSVHAADMDSKMNFDLNEGLVSDDGKYGEPTNLSTVNVVNSLTTTVSMLSSSIPASITVAAALKGPFVPPVDLLRNRGELGWKGSAATSAFRPAEPRKVLQLALGSANVCPPDDSSGKTSRPPLDIDLNVPDERLLEDMACRDSSAEIGSNPDHSVNLDRSRNELTGSAPGRMSGGLDLDLNRVDDANDITQYPTTSIRRLEAPVVPFKSLSSSSNNEVKRDFDLNNGPGIDDGVAEQSSFTQHSRGSTQSVHSLPTLAGLRSNNLETGNFSAWFPPGTSYSSITIPSALSDRGEQPFAIIPPGAPQRLLGSPAGNPFNPDVYRGSVLSSSPAVPFAPSPFPYQMFPFGTTLPLPSATFSVGSNSFMDSSSGGRIFTPPVNSQFLGPVGAVSSQFPRPYMVSVSDGSNSGGMESNRKWSRQGLDLNAGPGVLDIEGREESLAQRQLANEESSYSLSKGQCLTCMYMISSSLDGSSPGGQLVSGHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9N1</accession>
    <name>A0A068V9N1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00001848001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739247">
        <property type="protein sequence ID" value="CDP17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9N1"/>
    <dbReference type="Gramene" id="CDP17480">
        <property type="protein sequence ID" value="CDP17480"/>
        <property type="gene ID" value="GSCOC_T00001848001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9N1"/>
    <dbReference type="OMA" id="NCALYPA"/>
    <dbReference type="OrthoDB" id="1926275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9N1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF187">
        <property type="entry name" value="AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="225"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="8">
        <location>
            <begin position="549"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="8">
        <location>
            <begin position="686"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="850" mass="96049" checksum="E4060D6E2D716E8C" modified="2014-10-01" version="1">MGGVGKTTLAKHIHDHLLKNRNFKIYWVTVSQEFNIKKLQDDIAKCLGLDPWNEDDEHIKAAILSEALVQGSVLILDDVWKEIPLKEIGICHGANKCRLIFTTRSRQVCTGMDCQRELEVKTLDKNESWDLFKTTLRLKMELPADVEKVAQSVTERCAGLPLGIVTVAGSMKGATDIREWRNALEQLKACSVGYDAMEEKVFPILEWSFNRLNKCEKNCFLYCCLYPEDSKLKIKELIDLFIWAELMQERNSWSQEFDQGHAILNKLIKVCLLEETRGYGGGDCVKMHDLVRDMALRITDGKSNLQMNGDVPRFLVKSIGKGNSKVTLEPKKWTEDLHAVSFHSFSYPHPEIKVPPAWSPNCPKLSTLLLSDVSIKEIPDSFFRHMCGLKVLNLSRCEGITELPNSVSELVKLTALILRGCKDLRFVPPLGNLKQLRDLDLSFTKIEDLPQGLESLVNLQRLNLDECGAFSQKIIPKGTFSQLHRLQLLLLPPYPRVQVNDPEVLNQLESFEGCLSFTDFYKITRWPKYYNKQLHFHQCELGRGSNNLPDDMESLIIQDCEGMGIRSLSDVFRNFINLSHLFELEITDVVGIEFLWQLSSASPRDQLEVSYFSPLCDLQVLSLSGLPNLVGLFYGESEPSYLLPAGTFSSLRELNISKCHNMKQLFTVQLLQSLQNLETLTVIESGIFSSLKGLNISKCHNMKQLFTVQLLQSLQNLETLTVNYCEVLEEIAADGNGVGQGGGEGTQLTSCEGATATVINLPKLRRLRLDNLPQLKNICKAAMICNSIEDIAIFGCPNLKRLPLFLSTINGQLSLPSTLSKIRGDKEWWESLEWDYPSAKNALDPYFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAF0</accession>
    <name>A0A068VAF0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00011026001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739252">
        <property type="protein sequence ID" value="CDP17549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAF0"/>
    <dbReference type="STRING" id="49390.A0A068VAF0"/>
    <dbReference type="Gramene" id="CDP17549">
        <property type="protein sequence ID" value="CDP17549"/>
        <property type="gene ID" value="GSCOC_T00011026001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAF0"/>
    <dbReference type="OMA" id="FMVISHE"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAF0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="123" mass="13850" checksum="B75993EC3F936224" modified="2014-10-01" version="1">MVSEGLIEEKALDTFNLPHYRPSLEEVKTIIEKNHALKLSYLDTIQLRVIGAGAADCGKGYVFNANTNANYRAWSLRAIYEPIFQAHFGDGIMNNFFTKLAANISQHQGKMKRNCLVLCLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAH2</accession>
    <name>A0A068VAH2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00013234001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739256">
        <property type="protein sequence ID" value="CDP17686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAH2"/>
    <dbReference type="STRING" id="49390.A0A068VAH2"/>
    <dbReference type="Gramene" id="CDP17686">
        <property type="protein sequence ID" value="CDP17686"/>
        <property type="gene ID" value="GSCOC_T00013234001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAH2"/>
    <dbReference type="OMA" id="RAYTIND"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000145">
        <property type="entry name" value="receptor-like serine/threonine-protein kinase SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1082">
        <property type="entry name" value="OS06G0693000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Apple" evidence="21">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="151"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP17686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="466" mass="52548" checksum="D5F09F445A1DA6BF" modified="2014-10-01" version="1">MKVPDFAEPMAITEEECRKNCLDNCSCTAYAFYVGIGCMQWSGILIDSEQLPLDGTNLYIRVPNSEHDTKRGFKVAIASTVSAAAVLLALCVCLCWKCIAKHKGNEQQAKLSRMEEVHKVEDMVTVTMNQAKFEKLPLYTYEALANATDNFHSNKIIGKGGFGPVYKGKLFDGLEIAVKRLSNSSTQGIEEFMNEVMVISKLQHRNLVRLLGCCVEREEKMLVYEYMPNKSLDAYLFDANKPNILDWRRRVIIVEGIGRALLYLHRDSRLKIIHRDLKASNILLDEELKPKLSDFGFARIFGGNQDQANTNRVAGTYGYMAPEYAMEGRFSEKSDVYSFGVLLLEIVSGRRNTTFYSDENELSMPGHAWKSWNENEAAKLIDPAIFDLGAITEMLRYIHVGLLCVQESAKDRPDVSAVLLMLTSEISNLPRPKFPAYTGRIGFSEKSSRQRAYTINDMSLSSIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAW6</accession>
    <name>A0A068VAW6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00011870001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739271">
        <property type="protein sequence ID" value="CDP17886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAW6"/>
    <dbReference type="STRING" id="49390.A0A068VAW6"/>
    <dbReference type="Gramene" id="CDP17886">
        <property type="protein sequence ID" value="CDP17886"/>
        <property type="gene ID" value="GSCOC_T00011870001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAW6"/>
    <dbReference type="OrthoDB" id="1918918at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAW6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF215">
        <property type="entry name" value="OS02G0781300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="25404" checksum="6FB278BF53FA580F" modified="2014-10-01" version="1">MFKPSCSSSAPASSSIASQEAQVKYKGVRKRKWGKWVSEIRLPNSRERIWLGSYDSAEKAARAFDAALFCLRGKNAKFNFADIPPDLVGGRSLTPAEIQAVASEYANRYGNKEKQQQQGEGLIGEKEDDPLQFDQDTSPISSNSDGALQNVDWSFLGMLEPNGAATGATSNAPDYDLMLSSLDNLHEDMYMTPHVGTKVDVDHNFNGQHEDYQHLDENYSHQSFLWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB30</accession>
    <name>A0A068VB30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00003863001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB30"/>
    <dbReference type="FunCoup" id="A0A068VB30">
        <property type="interactions" value="1130"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB30"/>
    <dbReference type="Gramene" id="CDP17754">
        <property type="protein sequence ID" value="CDP17754"/>
        <property type="gene ID" value="GSCOC_T00003863001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB30"/>
    <dbReference type="OMA" id="IQYFIPA"/>
    <dbReference type="OrthoDB" id="4255at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12938">
        <property type="entry name" value="GUCT_Hera"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001060">
        <property type="entry name" value="ATP-dependent RNA helicase RhlE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000911">
        <property type="entry name" value="Nucleolar RNA helicase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="160"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="367"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="651"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP17754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="779" mass="84575" checksum="26647B8C11F164CB" modified="2014-10-01" version="1">MACPSSIIGVSSIYQTTPSLELSKRPTSTPPLSFPFPAEKSHFYGLKVTATSAASSSSSNVHLRSNGNTGSSFVASAVVTTNSSVLSEEAFKGLGDFGKGSFDVSESDYDDESEGEFDAEDGEVDGDELAISKLGLPQKLVETLETRGITHLFPIQRSVLVPALEGRDIIARAKTGTGKTLAFGIPIIKRLSEDEEERGPRRRSGQLPKVLVLAPTRELAKQVEKEIKESASYLNTVCVYGGVSYITQQNAISRGVDVVVGTPGRLIDLINSGSLKLGEVQYLVLDEADQMLAVGFEEDVEVILEKLPSERQSMLFSATMPGWVKKLARKYLDNPLTIDLVGDEEEKLAEGIKLYAIPTTPTSKRTILSDLITVYAKGGKTIVFTQTKRDADEVSLALTNSIASEALHGDISQHQRERTLNGFRQGKFTVLVATDVASRGLDIPNVDLIIHYELPNDPESFVHRSGRTGRAGKEGRAILMFTSSQRRTVKSLERDVGCRFDFISPPSIEEVLGSSAEQVVATLGGVHPESVSYFTPTAQQLMDERGVDALAAALAQLSGFSRPPSSRSLITHEQGWVTLQLIRDSGARGFLSARSVTGFLSDVYSTAADELGKIHLIADARVQGAVFDLPEEIAKELLNKELPPGNTISKITKLPALQDDGPPSDYYGKFSNRERGSRGSFRDQRGSRSSRSWSSSRFSNDEDGSRRGGWGSRSGSRFSDDDDFSRGGSRGGRSDWLINDRRSSRSAPFGSKDRGFGGACFNCGRNGHRASECPNKQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE05</accession>
    <name>A0A068VE05_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00004280001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739366">
        <property type="protein sequence ID" value="CDP18764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE05"/>
    <dbReference type="Gramene" id="CDP18764">
        <property type="protein sequence ID" value="CDP18764"/>
        <property type="gene ID" value="GSCOC_T00004280001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE05"/>
    <dbReference type="OMA" id="CDCTQES"/>
    <dbReference type="OrthoDB" id="1731741at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VE05"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000285">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF347">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="225" mass="25136" checksum="C003B69E3B56D5B3" modified="2014-10-01" version="1">MLSRVINNQTHKIYVPVLKACAALEHIDNGVKIHDDVKRDWLASDVYISTALVDFYVKCGCLLEARQVFNEMPERDVAWNAMISGFLIHGMHGDLIHFALEMQEMGVSPNSSTLVTILLVIGEVNEVIAGKAVQRLSVRRGIDSDVMMGTGRLDMNGKCGWLVYARRIFHAMTFRNEVTWSAMIGDCIACDCTQESLELFEQMRVEDVGSLPPVTLATVFQGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF27</accession>
    <name>A0A068VF27_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012023001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF27"/>
    <dbReference type="STRING" id="49390.A0A068VF27"/>
    <dbReference type="Gramene" id="CDP18293">
        <property type="protein sequence ID" value="CDP18293"/>
        <property type="gene ID" value="GSCOC_T00012023001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF27"/>
    <dbReference type="OMA" id="YIKCDFR"/>
    <dbReference type="OrthoDB" id="1839683at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF27"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34052">
        <property type="entry name" value="GLYCINE-RICH PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34052:SF2">
        <property type="entry name" value="PLASTOCYANIN-LIKE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658568" description="Phytocyanin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="146" mass="15824" checksum="4381ADC3B4CEB929" modified="2014-10-01" version="1">MAISFGKGLLVLLLTLVATLAISQAETVVVGGSEGWRYGYNYTEWAFNHGAFFRGDILVFKYPPPSDTVKPHSVYLLPNLYSFLTCDFSHATLLAGPNQGGGDGFSYVLTKISPNYFASGEGNGDDCNKGLMKFDAIPLYRPPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFJ2</accession>
    <name>A0A068VFJ2_COFCA</name>
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        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012168001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739538">
        <property type="protein sequence ID" value="CDP19357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFJ2"/>
    <dbReference type="Gramene" id="CDP19357">
        <property type="protein sequence ID" value="CDP19357"/>
        <property type="gene ID" value="GSCOC_T00012168001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFJ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="22" mass="2513" checksum="2091065DF1F7FB65" modified="2014-10-01" version="1">MDEQYMGKLLVGFLSCDDNCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGR5</accession>
    <name>A0A068VGR5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005827001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739383">
        <property type="protein sequence ID" value="CDP18878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGR5"/>
    <dbReference type="SMR" id="A0A068VGR5"/>
    <dbReference type="FunCoup" id="A0A068VGR5">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGR5"/>
    <dbReference type="Gramene" id="CDP18878">
        <property type="protein sequence ID" value="CDP18878"/>
        <property type="gene ID" value="GSCOC_T00005827001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGR5"/>
    <dbReference type="OMA" id="MQKLIRR"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF35">
        <property type="entry name" value="DEOXYADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="548" mass="60707" checksum="993665E42DB92728" modified="2014-10-01" version="1">MPSTATGFYLRGATSTRALSHPAAAAGRSKAPLLPSTARTLNVPLLGNGCGLCKCAVEGGGGSVGLVRAWVVLRENSRCGNRKAWFGAVAVAEKDGGAVVESAEKGLEAPAEAAAQVRVQRKQRTAAGGGSGGGGGLPSPGSPDLLSIPGVGPRNLRKLVEKGFDGVAKLKQLYRDKFCGKSSQTMVEYLQSSVGIIHRNHAESITTYIKESVDEELKDDDTEVKLAPKKRLTFCVEGNISVGKTTFLHRIAHETLELRDLVEIVPEPIDKWQNVGPDHFNILDAFYAEPHRYAYTFQNYVFVTRVMQERESSGGIKPLRLMERSVFSDRMVFVRAVHEAKWMNEMEISIYDSWFDPVVSCLPGLIPDGFIYLRASPDTCHKRMLLRKREEEGGVSLDYLRDLHEKHESWLFPFQSGNHGVLSVSEIPQRFDSSLPPDIRDRVFHLEGDHMHSSIQKIPALVLDCEPNIDFSKDVEAKRHYARQVAEFFEFVKKGKEDSPVSEDASKGNQPQVLLPHQRGLWVPDGKYFPESPLKSLDFRKAMPLTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJE9</accession>
    <name>A0A068VJE9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00010988001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739783">
        <property type="protein sequence ID" value="CDP19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJE9"/>
    <dbReference type="STRING" id="49390.A0A068VJE9"/>
    <dbReference type="Gramene" id="CDP19803">
        <property type="protein sequence ID" value="CDP19803"/>
        <property type="gene ID" value="GSCOC_T00010988001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJE9"/>
    <dbReference type="OMA" id="YQGHQNK"/>
    <dbReference type="OrthoDB" id="1917746at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJE9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF72">
        <property type="entry name" value="NDR1_HIN1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="6">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="251" mass="28011" checksum="919D9A86A1277B96" modified="2014-10-01" version="1">MADHQTKIHPVLDIEAPSSARTLVPEGSVRSEKGDPAILHQPQIQENIPLMHSKPPKNKSCCCKFLCWTISLILILLIILGATAAILYVVFQPKIPQYSVDNLRISDLRLNFDLSLYAKFNLRITADNPNKKIGIYYEKGSHLSVWYKSTDLCQGTLPKFYQGHQNKTVLNVALTGQAQYGSTLLAALQEEAQTGRIPLDLKIDVPVSIKLGKLKMRKVRVLGSCMLIVDSLSTNSLISIKARTCKFRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJS9</accession>
    <name>A0A068VJS9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Patatin</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00011089001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Lipolytic acyl hydrolase (LAH).</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the patatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG740913">
        <property type="protein sequence ID" value="CDP20829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJS9"/>
    <dbReference type="Gramene" id="CDP20829">
        <property type="protein sequence ID" value="CDP20829"/>
        <property type="gene ID" value="GSCOC_T00011089001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJS9"/>
    <dbReference type="OMA" id="PKIFEDR"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJS9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32176:SF120">
        <property type="entry name" value="PATATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32176">
        <property type="entry name" value="XYLOSE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="104" mass="11283" checksum="D8E8692D38943C65" modified="2014-10-01" version="1" fragment="single">MESPRSFLQTPTYGNSITILSIDGGGIRGIIPGVILGFLESELQKLDGEDARLADYFDVISGTSTSGLVTAMLAAPNDKNRPLFAAKEIKDFYLDNCPQIFPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK72</accession>
    <name>A0A068VK72_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00002166001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741379">
        <property type="protein sequence ID" value="CDP21017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK72"/>
    <dbReference type="STRING" id="49390.A0A068VK72"/>
    <dbReference type="Gramene" id="CDP21017">
        <property type="protein sequence ID" value="CDP21017"/>
        <property type="gene ID" value="GSCOC_T00002166001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK72"/>
    <dbReference type="OMA" id="TENVQWV"/>
    <dbReference type="OrthoDB" id="1858978at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1320.10">
        <property type="entry name" value="Outer-capsid protein sigma 3, large lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF57">
        <property type="entry name" value="OS06G0474500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="171" mass="18701" checksum="BAD4D1B5A8D647A5" modified="2014-10-01" version="1">MVFPSLFGDSNTRLFTYWTSDGYNSTGCYNLRCPGFVHASNSIALDVALSPVSTYHGAQHEIILHIFKDPKQNVWWLQHGNDDVIEIINNAQDGQHTTTQMGSGHFAEEQAGGASYFKNLQVVDQSNALVPPGDIKAVATKPNCYNIVPGKSDDAGDYFYFGGPGRNPNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKK2</accession>
    <name>A0A068VKK2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_2572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00010169001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741656">
        <property type="protein sequence ID" value="CDP21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKK2"/>
    <dbReference type="STRING" id="49390.A0A068VKK2"/>
    <dbReference type="Gramene" id="CDP21129">
        <property type="protein sequence ID" value="CDP21129"/>
        <property type="gene ID" value="GSCOC_T00010169001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKK2"/>
    <dbReference type="OMA" id="EVSACTI"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22005">
        <property type="entry name" value="HMG-box_AtHMGB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031061">
        <property type="entry name" value="HMGB_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261:SF18">
        <property type="entry name" value="DNA-BINDING PROTEIN MNB1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="140" mass="16115" checksum="408915AFC43412C9" modified="2014-10-01" version="1">MKGGKSKADSRNPDSKLSVKKRKQKREKKAKDPNKPKRPPSAFFVFMEEFRKQFKEENPNNKLVAVVGKAAGDKWKSFTDEEKAPYVARAEKRKQDYERQMQAYNRRLEGGHGEEGSDKSKSEVNDDDEEGSGEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKX4</accession>
    <name>A0A068VKX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">xyloglucan 6-xylosyltransferase</fullName>
            <ecNumber evidence="12">2.4.2.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00002557001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-(1-&gt;6)-D-xylosyl-D-glucose linkage.</text>
            <dbReference type="EC" id="2.4.2.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.39" evidence="12"/>
    <dbReference type="EMBL" id="HG742053">
        <property type="protein sequence ID" value="CDP21247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKX4"/>
    <dbReference type="FunCoup" id="A0A068VKX4">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VKX4"/>
    <dbReference type="Gramene" id="CDP21247">
        <property type="protein sequence ID" value="CDP21247"/>
        <property type="gene ID" value="GSCOC_T00002557001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKX4"/>
    <dbReference type="OMA" id="FALGPKI"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033843">
        <property type="term" value="F:xyloglucan 6-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009969">
        <property type="term" value="P:xyloglucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000032">
        <property type="entry name" value="xyloglucan 6-xylosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF44">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP21247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="436" mass="49299" checksum="E3E317AD27B32829" modified="2014-10-01" version="1">MGQESNFTPQKRPGTLPTTAAAATANGGGGGGRSHSSSVVPRGRQISKTFNNIKITILCGFVTILVLRGTIGFGNLAVVVDDNSNGTYSLGPKIKNWDEQRKVWLSKNPEFPNFVNGKPRILLVTGSPPNPCDNAIGDHYLLKAVKNKIDYCRIHGIEIVYNMAQFDKEMAGYWSKLPLIRRLMVSHPEIEWIWWMDSDALFTDMAFEIPVTKYSEHNLVVHGYEDLLFEQKSWIALNTGSFLLRNSQWSLDLLDAWAPMGPKGYVRDEAGKILTANLKGRPKFEADDQSALIYLLITKKKQLMDKVFVESSYYLHGYWAGLVDRFEEMIEKYHPGLGDERWPFVTHFVGCKPCGSYGDYPAERCLKSMERAFNFADNQVLKLYGFKHRGLVSPNIKRIRNETAIPLVSVDQFDIRHSRQHSKFIVCLCHSKRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL99</accession>
    <name>A0A068VL99_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_1217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00006087001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740301">
        <property type="protein sequence ID" value="CDP20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL99"/>
    <dbReference type="STRING" id="49390.A0A068VL99"/>
    <dbReference type="Gramene" id="CDP20453">
        <property type="protein sequence ID" value="CDP20453"/>
        <property type="gene ID" value="GSCOC_T00006087001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL99"/>
    <dbReference type="OMA" id="FTTHRAN"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VL99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20618">
        <property type="entry name" value="CYP71_clan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF5">
        <property type="entry name" value="CYTOCHROME P450 71A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="425" mass="49279" checksum="EC0B45B138A47D54" modified="2014-10-01" version="1">MAKEFLKTHDDIFASRPTTAAGKYTSYNCSDVSWAPYGPHWRQARKIYLSQIFSQKPLDSFESIRIEERRAFISRLYALSGKPVVMRDHLMRLTLSTASQMVLSNKYFAQSEEDGSLVTFEEFQEMIDTWFLLGGVFNIGDWIPWLDRFDLQGYIKQMKELDKKFDRFHNHVLDDHQAKRKTEKDFIPTDMVDILLQYAEDPDLRVKLTRDQIKGLIQDLLAAGTDTSASTVEWAMNELLKHPRLIEKATEELDRVIGRDKWVEEADFSKLPFLEAIIKETFRLHPITTLLPPHYAIEDGTVAGYHIPKGTTVLINTWSIGRNSKYWDSPEEFMPERFLEKDVDMKGQNFALLPFGSGRRRCPGYNLGLKLVRSMLANLLHGFNWKLPHGMKPEEICMEELYGLTTHPRTPLAMIPEPRLPVNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMH3</accession>
    <name>A0A068VMH3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_6836</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00002540001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG745920">
        <property type="protein sequence ID" value="CDP21812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMH3"/>
    <dbReference type="Gramene" id="CDP21812">
        <property type="protein sequence ID" value="CDP21812"/>
        <property type="gene ID" value="GSCOC_T00002540001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMH3"/>
    <dbReference type="OMA" id="VLIFIDC"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMH3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="162"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="428"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="550"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="751" mass="85914" checksum="E999B5D8A620BCDD" modified="2014-10-01" version="1" fragment="single">MAETVLSFVLRQLSTFLHEEGRLLGGLRQEVQFIKDELGHMRAFLREAEAKEEDAQPRLQEWIKQVREAAYDTEDILDEFVVRFARHPATGFYGSVRRIFSSIKNLRARHRVASEIQGIKSRIKSISEAHQRYQSEYVNNTTWRYSRDDALLVEEAKLVGIDQRKNHLISELLEGDDHQLKVVSVVGMGGLGKTTLVKKVHEDPEVRRHFPVRAWVTVSETCDFQFLLKDLIRQLHEEGKKPVPQSIESMTTTELKKFVKDFLQQAGRYAIVFDDVWDVEFWNTIKFALPESCCGNRVMLTTRRADVASASCIESRGFVYRMEPLSVEDSRTLFCNKIFNGANCPGHLMDVAKGILDKCEGLPLAIIAISGLLASKDVNRIDEWEMVRRSLGGELEGAGKLDRVKKILSLSYNDLPGHLKTCLLYTSIYPEDYKIGCLRLVNLWIAERFVEWREGMSIEDVAWGYFSELINRSLIQVTGVFYEGMPGNCRVHDLLREIIISKSREQNMVTITTGQPTRWLSEKVRRLIVHTSSSNNTQHHQQMQNYCFDHLRSFVTIGSMNPLLLKTLLFDVLGSSKLLKVLDLRGQETEEEMPNEIFKMFHLKHLDLYHTRVERVPKAIGKLQHLEYLNLGNTGVRELPMEILKLQKLRVLKVYQQVDSSDDDYGFHGFKAPSNMGVLLALEILDSIDASSGSTIVKEIGKLTQLRELSITNLRELNIASIGKGDDHDTIDLSHHHPSLSSSFLQSLRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMP8</accession>
    <name>A0A068VMP8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_8501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00000592001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG747585">
        <property type="protein sequence ID" value="CDP21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMP8"/>
    <dbReference type="Gramene" id="CDP21971">
        <property type="protein sequence ID" value="CDP21971"/>
        <property type="gene ID" value="GSCOC_T00000592001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMP8"/>
    <dbReference type="PhylomeDB" id="A0A068VMP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053098">
        <property type="entry name" value="Petuviruses_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435:SF1">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="289" mass="33219" checksum="200B9B3E94F8BD75" modified="2014-10-01" version="1" fragment="single">KQWEIHDDHPQNLQQVHRSQDIIIYFDKEGLPVSWFQDPISGHIYFDVCNVCEECQVENILGLDLPDLPCKKKSKSKQDLHPYYQKCLNILEKEGEKSKWNLKPFCKPEPLVPIHTPQIQECFMFSEADFPKFETFNKNGSRHTPKIQNISSTILPSGETVRPNPAEDVLNWQTENSLVQNTALISIHKNISEAKDKIEQIDTTVSTQQSQVSHMIEVFEKRLQELKYIMPSDPSTLADFILNKEKETKFIQDQLHVLKTTGQVPTYDVGPSSPLSRVSSMYGAVPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN68</accession>
    <name>A0A068VN68_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00011984001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG748810">
        <property type="protein sequence ID" value="CDP22064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN68"/>
    <dbReference type="FunCoup" id="A0A068VN68">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP22064">
        <property type="protein sequence ID" value="CDP22064"/>
        <property type="gene ID" value="GSCOC_T00011984001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN68"/>
    <dbReference type="OMA" id="HFQLSIV"/>
    <dbReference type="OrthoDB" id="1879185at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN68"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000005">
        <property type="entry name" value="Germin-like protein subfamily 1 member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019611168" description="Germin-like protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="12">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP22064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="230" mass="24848" checksum="73AA93C04139118F" modified="2014-10-01" version="1">MAFRFHIAAAILALVFTIVHASDPSPLQDFCVAVPDANAGVFVNGKICKDPKLVEAKDFFFPGLKEPGSTSNPLGSNVTAVNVNQIPGLNTLGVSLARIDFAPYGLNPPHTHPRATEILVVLEGTLLVGFVTSNPGMNMKNKLFTKVLNPGDVFVFPEGLIHFQFNKGHSSAVAFAGLSSQNPGVITIANAVFGSKPPISRDVLTKAFQVDKNVVKYLQSQFWRDNHYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VP71</accession>
    <name>A0A068VP71_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DH200=94 genomic scaffold, scaffold_4608</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00003975001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743692">
        <property type="protein sequence ID" value="CDP21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VP71"/>
    <dbReference type="STRING" id="49390.A0A068VP71"/>
    <dbReference type="MEROPS" id="M41.A06"/>
    <dbReference type="Gramene" id="CDP21508">
        <property type="protein sequence ID" value="CDP21508"/>
        <property type="gene ID" value="GSCOC_T00003975001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VP71"/>
    <dbReference type="OMA" id="LWISKIW"/>
    <dbReference type="OrthoDB" id="2016403at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VP71"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000101">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 12, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001118">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 12, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF19">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 12, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="203"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="613" mass="70042" checksum="D1281B46743E5E6F" modified="2014-10-01" version="1" fragment="single">MKEVENSLRKDVLEKVKDNHGNRALWISKRLWRYRPKLPYMYFLQKLDSSEVAAIVFTEDLKRLYVTMKEGFPVEYIVDIPLDPYLFEMISSSGAEVDLLQKRQIHYFLKVVFALLPGILILWFIRESLMLLHVTSRRFLYKKYNQLFDMAYAENFILPVGEVGETKSMYKEVVLGGDVWDLLDELMIFMGNPMHYYEKEVKFVRGVLLSGPPGTGKTLFARTLAKESGLPFVFASGAEFTDSEKSGAARINEMFSIARRNAPAFVFVDEIDAIAGRHARKDPRRRATFEALIAQLDGEKERTGVDRFSLRQAVIFICATNRPDELDLEFVRPGRIDRRLYIGLPDAKQRVQIFGVHSAGKRLAEDVDFEKLVFRTVGYSGADIRNLVNEAGIMSVRKGHTNIYQQDIVDVLDKQLLEGMGVLLTEEEQQKCEQNVSFEKKRLLAVHEAGHIVLAHLFPRFDWHAFSQLLPGGKETAISVFYPREDMVDQGYTTFGYMKMQMVVAHGGRCAERIVFGDDITDGGQDDLEKITKIAREMVISPGNPRLGLTALTRRLGLVERPDNPDRELITYKWDDPHVIPADMTVEVSELFTRELARVSEVSLCDCFMFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLA5</accession>
    <name>A0A068TLA5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014234001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLA5"/>
    <dbReference type="STRING" id="49390.A0A068TLA5"/>
    <dbReference type="Gramene" id="CDO97021">
        <property type="protein sequence ID" value="CDO97021"/>
        <property type="gene ID" value="GSCOC_T00014234001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLA5"/>
    <dbReference type="PhylomeDB" id="A0A068TLA5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="108" mass="12365" checksum="D7EBCD5BE3343672" modified="2014-10-01" version="1">MPLPQKILWSMAMYLVSYKANVFSFFQVLGIIDQPILRERWVGLNGRKTTLNGQDISTRGCAKLSQAYLYTTSPHLFNGDAEVAFARVRDKVHPLCPRNNQIDAYKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLP3</accession>
    <name>A0A068TLP3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00014381001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLP3"/>
    <dbReference type="FunCoup" id="A0A068TLP3">
        <property type="interactions" value="3142"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLP3"/>
    <dbReference type="Gramene" id="CDO97136">
        <property type="protein sequence ID" value="CDO97136"/>
        <property type="gene ID" value="GSCOC_T00014381001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLP3"/>
    <dbReference type="OMA" id="CFRGPFV"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042868">
        <property type="term" value="P:antisense RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009553">
        <property type="term" value="P:embryo sac development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016441">
        <property type="term" value="P:post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="entry name" value="Cleavage stimulation factor subunit 77"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="5"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO97136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="736" mass="82967" checksum="73F1D673EC929553" modified="2014-10-01" version="1">MTTTDKYNVEAAELLANEALHLPISEAVPVYEQLLATFPTAAKYWKQYVEAHMAVNNDDAVKHIFSRCLLNCLHIPLWRCYIRFIRKVNDKKGIEGQEETRKAFDFMLNYVGADIASGPLWMEYTAFLKSLPTQNLAEETQRMTSVRKAYQKAIITPTHHIEQLWREYENFENSVSRALAKGLLSEYQPKYNSARAVYRERKKFADEIDWNMLAVPPSGTSKEEMQWIAWKRFLAFENGNPQRIDSASANKRIAFTYEQCLMYLYHYPDIWYDYATWHAKSGSVDSAIKIFQRALKALPDSEMLKYAYAELEESRGSIQASKKVYESLLGDDGNATALSHIQFIRFLRRTEGVEAARKYFMDARKSPNCTYHVYVAYAMMAFCLDKDAKFAHNVFEAGLKRFMHEPSYILEYADFLSRLNDDRNIRALFERALSSLPPEESVEIWKRFTQFEQTYGDLSSILKVEQRRKEALSRAGDEGESALNSSLQDVISRYSFMDLWPCSSKDMDHLTRQEWLSKNISKKIEKPTPANGVSSVDKRSSAVSTTSNSVKVVYPDTSKMVVYDPRQKIGLTGPLQPGVAVALPPNDTMGAAGAPNVLKDILKTLPPALATFVANLPAVEGPSPDVDFVLAICLQSNIPLMPVRAANSTKLQTGPAPSTSDLSGSSKFKPTRDRHAGKRKDVDKQDDEDSTTVQSQPLPRDAFKLRQLRKARGASSQTGSASYGSAFSGEMSGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQF7</accession>
    <name>A0A068TQF7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Miraculin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022699001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068TQF7"/>
    <dbReference type="MEROPS" id="I03.030"/>
    <dbReference type="Gramene" id="CDO98560">
        <property type="protein sequence ID" value="CDO98560"/>
        <property type="gene ID" value="GSCOC_T00022699001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQF7"/>
    <dbReference type="OMA" id="VYCPSVF"/>
    <dbReference type="OrthoDB" id="1872570at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23375">
        <property type="entry name" value="beta-trefoil_STI_VvMLP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011065">
        <property type="entry name" value="Kunitz_inhibitor_STI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002160">
        <property type="entry name" value="Prot_inh_Kunz-lg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107:SF5">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00197">
        <property type="entry name" value="Kunitz_legume"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00291">
        <property type="entry name" value="KUNITZINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00452">
        <property type="entry name" value="STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50386">
        <property type="entry name" value="STI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654196" description="Miraculin-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23518" checksum="A469E715B7A179DF" modified="2014-10-01" version="1">MKAPLVLFPLVLISIYTNSLFCQAAAESVQPAAVFGVDGKEVRTDLFYYIRPANNRGKDRGGGLGLRSIGNDSCPLVVIQETNELRDGLPLTFSPAVAPKDNVVRVSTDLNIQVAFPDTCNQPTVWRVDVSDKSEGRKFVNLGGVIGNPGPETLGNWFKIEKVGDHGNKYKLVYCPTVCSYCKVNCKNLGIVYQNGLRRLALSHRPFKVIFTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQS9</accession>
    <name>A0A068TQS9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00022842001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDO98670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00022842001"/>
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        <property type="component" value="Chromosome VI"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
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        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
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    </dbReference>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="169"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO98670.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="42114" checksum="35080C4CC6194C81" modified="2014-10-01" version="1">MKKKNQKTTDSSAAALIPTRSTADLKALIQSHSDFFDRLIELIPARFYLPPDDDVSDNPKPYFHGLSKAAKASLKRQSKQNLKLARRNRLDPDKISHSSTLDLLKQSLDTSAHGGEVAEIPAQDVPRAIDLEEKNGGDGNDGEKGQEKQVTYEELREKLRKKIESLRGNRGEGNRSARKGREDNKDRDNHRGEKKRKRDGEGSSGKGVEVVENDSEEIIEYGKVKIGDDEMEGEKRKKKRKMSKVKELDRAKRLEEVKKENPRVAEREWWRAAENRAMGVKVHDDPRLLRESMKKEKKRKEKNAEKWKERIEGQEKAKEGKQQKRKENIEGRIRDKKMRKIAKREKKLMRPGFEGRKDEYITKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">GSCOC_T00026185001</name>
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        <name type="scientific">Coffea canephora</name>
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00026185001"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35700">
        <property type="entry name" value="OS07G0181800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35700:SF1">
        <property type="entry name" value="OS07G0181800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO99140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="76" mass="8719" checksum="A1ECB2EF59F504ED" modified="2014-10-01" version="1">MSSLGTSKGVLEIAKFAVYVSVPIGLMYFYANNTKNLQKFMGNRQYVVYPPEAPRPPSPEELRERARELARKRNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTD4</accession>
    <name>A0A068TTD4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="13 14">
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        <lineage>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTD4"/>
    <dbReference type="FunCoup" id="A0A068TTD4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO99302">
        <property type="protein sequence ID" value="CDO99302"/>
        <property type="gene ID" value="GSCOC_T00026411001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTD4"/>
    <dbReference type="OMA" id="GHINELP"/>
    <dbReference type="PhylomeDB" id="A0A068TTD4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1185">
        <property type="entry name" value="DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
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    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="172"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="11">
        <location>
            <begin position="433"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="12">
        <location>
            <begin position="580"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO99302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="112617" checksum="20B55FF7A5978193" modified="2014-10-01" version="1">MAELAEPVVSFIIERLSNLCIEEGKHLHGASDQAEQLQSELKLMQGLLRDADAKQRDDAVIREWISQSKDLAYEAEDLIETFAFKVGSRRGGGLVNVLKRYTCIFKECYMRHRVGVDIQGLNTRVSNLTSCFRDYGIRTIVEKEGPSSRQLQWIRRIYSHVEEEDFVGLERNVEVLVPKVVSEDGTSHYRVVSICGMGGLGKTTIARKVYNHPNVRRHFDRFAWFCISQQWQTKEILQGILVNLIPEKKDEIVKSWSADELVRQLYHIQQNKRCLIVLDDIWSFDAWECIKYAFPTREKGSKILVTTRNKDVVVRMDAFHHEPRLLSFDESWELFQKKALGERYNHEGPITGELAQISKKILDGCGGLPLAIILCARMLRTAKEDEWLKVLQSLPKTKSRWMYGGPQGLDYLWSAYCALPLRLKACFLYLGNFPNNSRIQVEKLCQLWIAEGLISAEDRASEETMMDVAAKYFSELVVRSLVTLEEDEVSDLRLMSGHVHDLIRDLCISVGAEVEFFEIMEREGTSYYQRQMRSEAQRCAIYFNRYYNVSDVFPSYNLRSLLCLNSERSGQGSRWPRGLFNFKKLRLLRVLDFDRVSFQDGKLPEGVGELVHLRYLSFRGCYLEHLPSYIGNFLYLQTLDLRVQKDCIMTISNVIWKLKRLRHLYFPLAFQTSDHHGMLKLDSLKELEILEGLDTSVCKAEDLIKLTNLRILAATAEGNLKDLELIIRCIGINSSHLKRTSLDIKKFDCYSEERLSLIKRLFSCPVLDTLQIEGRIGKTSEIGTISGRFTEIVLNGSELDQDPMPTLENLPNLRILVLEVEACLGKKLRCSDTGFPELRSLKLSKLYNLEEWEVGKGALQKLSTLEVSMCRRMKKLPEGLQSIITLRKLKISMMPQQFLGRLRMKNGTGGEDRHKINSKCSIEFGNDDPWLESTNSASQQNNSFDGRITESQASSSSHSPNLIGSFACIPETERERDVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUC4</accession>
    <name>A0A068TUC4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029537001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUC4"/>
    <dbReference type="FunCoup" id="A0A068TUC4">
        <property type="interactions" value="1103"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUC4"/>
    <dbReference type="Gramene" id="CDO99841">
        <property type="protein sequence ID" value="CDO99841"/>
        <property type="gene ID" value="GSCOC_T00029537001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUC4"/>
    <dbReference type="OMA" id="TIKQKPW"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="637" mass="68401" checksum="27298E393A3DEB05" modified="2014-10-01" version="1">MALSRLRNPVISRAPSLLRARLFSSTCRSLPRSSRVLSSFADVEGTLSRTTSVPVFGRLHGHSSKTKSRIGVRYFSSADPLQTVVGMPALSPTMSQGNIAKWRKKEGDKINVGDVLCDIETDKATLEFESLEEGFLAKILVPEGSKDVPVGQPIAITVEDPDDIKNVSVPAGGGAEVKEETSEKRIGNEEKKQQTSSLKTNTAELPPHFVLGMPALSPTMSQGNIAKWRKQEGDKIEVGDVLCEIETDKATLEFESLEEGFLAKILVPDGSKDVPVGQPIAVTVEDPNDIESVKTSFSGDGMLQEDKPVRHDPTSKTKAQKTSFSRISPSAKLLILEHGLDASSIPPSGPRGTILKGDVLAAIKSVIGSSKISSSKEKQTPSPPVKSQTASPGLSGLKSTLPQADAYEDLPNSQIRKVIATRLLESKQSTPHLYLSSDVILDPLLSFRKELKENFDVKVSVNDIVIKVVATALRNVPEANAYWDVKKGEAVFSDAVDISIAVATDKGLMTPIIRNADQKSISAISLEVKELAERARAGKLKPNEFQGGTFSISNLGMFPVDHFCAIINPPQAGILAVGRGNQVVEPVVGADGIEKPGIVTKMSLTLSADHRVFDGHVGGAFLAALRSNFSDIRRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUJ3</accession>
    <name>A0A068TUJ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00029337001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUJ3"/>
    <dbReference type="STRING" id="49390.A0A068TUJ3"/>
    <dbReference type="Gramene" id="CDO99672">
        <property type="protein sequence ID" value="CDO99672"/>
        <property type="gene ID" value="GSCOC_T00029337001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUJ3"/>
    <dbReference type="OMA" id="PIAHESK"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUJ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000330">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase At4g03230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021820">
        <property type="entry name" value="S-locus_recpt_kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1097">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11883">
        <property type="entry name" value="DUF3403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="132"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDO99672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="450" mass="51526" checksum="7C5DF74D25131A34" modified="2014-10-01" version="1">MARAEIGKRLHSAVWNVILDIDIRNALIFCRGCRILVFEKNLSKIDLMNEYQPKHVRLVIAITMLSAFALLLLAILAWYKLRPKGRREEDTISMPIAHESKSFPHYEEESQEEDLELPTFDLATISAATDQFALRNKIGQGGFGPVYKGELPNRLEVAVKRLSQNSGQGLREFKNEVILIAKLQHRNLVRLLGCCIQGDEKMLVYEYLANKSLDNFIFDRIKRKLLPWSIRFNIVLGIARGLLYLHQDSRLRIIHRDLKTSNILLDREMNPKISDFGIARIFGGEITEEKTRRIIGTYGYMSPEYAMSGHFSVKSDVFSFGVIVLEIISGRKNWGFYDPDHDHNLIGHTWKLWNEKRSIELVDDILDGSFSKDEVLRCIQVALLSVQQRTEERPTMSTVVFMLSNENVELPQPKEPGFVSERSAMKIDSSSSGQDFHTGNHITFTTAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUU7</accession>
    <name>A0A068TUU7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00029791001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUU7"/>
    <dbReference type="FunCoup" id="A0A068TUU7">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUU7"/>
    <dbReference type="Gramene" id="CDP00031">
        <property type="protein sequence ID" value="CDP00031"/>
        <property type="gene ID" value="GSCOC_T00029791001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUU7"/>
    <dbReference type="OMA" id="PTRENGW"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057528">
        <property type="entry name" value="MPK1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381">
        <property type="entry name" value="MKPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381:SF4">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE MKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25466">
        <property type="entry name" value="MPK1_gelsolin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="140"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP00031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="94745" checksum="436B7A6E28E14CB4" modified="2014-10-01" version="1">MVGKEDAPSGGEGGGGCEGGLQRPYQVVGGRKLFWRSASWSSSRTTLPPLNPYSEKDGLDPPENANGNGQGRRVSGPLTPRSQNSFKNRSCLPPLQPLSIARRSLDDWPKAGSDDIGEWPLPSTPSGRDVNNGGERLKLDLSNIQRNSDRNGGLVKREKIAFFDKECSKVADHVYLGGDAYFKADFVYRTLWLQDSPTEDITSILYDVFDYFEDVREQGGRVFVHCCQGVSRSTSLVIAYLMWREGQSFDDAFQYVKAARGIADPNMGFACQLLQCQKRVHAFPLSPSSLVRMYRIAPHSPYDPLHLVPKMLNDPSPSALDSRGAFIVHIPSAMYVWIGKKCEMIMERDARGAVCQIVRYEKVQGPVVMIKEGEEPSFFWDAFSSLLPLMDKSSSNVDVVDASIKICPGNRIIDSYSVDFEIFQKAIMGGFVPPFASSETEQETHLPARESSWSVLRRKFISGNMKEFVSAMKSGVSIVYPDSLFIVEEQCRAQQSHSSASSLLSLMPSLSSSSSSSASSSSLSSLSSSSSSSSSSPPYLSPDSSSDASINSTIQSDSPDMSPSAASGPGLTSSLLSNLCNMTLLSSKISPQSISKSSKFIDVNFSSESCLRSASTASKKFPLSIAERRGSLSKSLKLQMLTDDSQGREMPTNSLTNEQDTVTTKHDACSLSKSLETQDSLDSEEQDVMHDELKLQSPLGTVGSCHADAAFRKNSDLHIVNHHLGKEESAISNGTLENGMASSGFIKPIVYRWPSLEKVVTFGSDDFDSQSAFVVITSSSCPTFGKTGAGILYFWVGRLFNCNSWNTKLESNQKFGGLVEFDWKQASSDVISRLGLPNDIKIEIIKEKNEPAEFLSLLKYLSFLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVA0</accession>
    <name>A0A068TVA0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00029622001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVA0"/>
    <dbReference type="FunCoup" id="A0A068TVA0">
        <property type="interactions" value="2522"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVA0"/>
    <dbReference type="Gramene" id="CDO99909">
        <property type="protein sequence ID" value="CDO99909"/>
        <property type="gene ID" value="GSCOC_T00029622001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVA0"/>
    <dbReference type="OMA" id="ENTWEEM"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVA0"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000002">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002049">
        <property type="entry name" value="PRK00881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="82"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO99909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="613" mass="66417" checksum="B320959DE10FFC97" modified="2014-10-01" version="1">MLGFSAAVASRSPVSTDAANLAAVLAAPSAPRAIAALPLFVRITNTISPSNLEYLSSSMTSLRSNSCSSVKAMAEAGALSAPTTPAHGRKHALISLSDKTDVAILGSGLQELGYTIISTGGTASALESDGLSVTKVEDVTGFPEMLDGRVKTLHPSIHGGILARRDLEHHMEALDKHKIGTIEVVVVNLYPFYEKVSSSSGISFEDAIENIDIGGPAMIRAAAKNHKDVLVVVDPEDYPALLEFLRGKQDNQQFRRKLSQKAFQYAASYDTAVSEWLWKQTSEDKFPPNMTLSLSLKSALRYGENPHQKAAFYVDKSLAEVNGGGIATAIQHHGKEMSYNNYLDADAAWNCVCEFNRPTCVIVKHTNPCGVASRDDIVEAYRLAVKADPVSAFGGIVAFNVEVDEVLAKDIREFRSPTDNETRMFYEIVVAPKYTKKGLEVLRGKSKTLRILEASKNRKGKLSLRQVGGGWLAQDSDDLVPEDIEFKSVADKAPQESELSDARFAWLCAKHVKSNAIVIAKDNCMLGMGSGQPNRLESFRIALRKAGDEVKGAALASDAFFPFAWNDAVEEACQSGISVIAEPGGSIRDVDAIDCCKKYGVSLLFTNVRHFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVQ8</accession>
    <name>A0A068TVQ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00029808001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVQ8"/>
    <dbReference type="FunCoup" id="A0A068TVQ8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVQ8"/>
    <dbReference type="Gramene" id="CDP00044">
        <property type="protein sequence ID" value="CDP00044"/>
        <property type="gene ID" value="GSCOC_T00029808001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVQ8"/>
    <dbReference type="OMA" id="PRLMEVD"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVQ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374:SF471">
        <property type="entry name" value="OS03G0279700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26374">
        <property type="entry name" value="ZINC FINGER PROTEIN ZAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="210" mass="23000" checksum="E0B2D6181C1AA240" modified="2014-10-01" version="1">MNMMNVGTKRAREPDQFDSITTMANCLMLLSRAGEFEALNIFHHNNSSDNSHNPSRVFECKTCNRQFPSFQALGGHRASHKKPKLGADLSLQSQVQTSPPKPKTHECSICGQEFAVGQALGGHMRRHRAAMNEEIGYHQSPVSSLSSGQQHQSPVSSLSSGQHEPVVQKSNTSSGRVCCLDLNLTPLENDLEFRLGKVVAPPVDCFLQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVR2</accession>
    <name>A0A068TVR2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein UXT homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00032304001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVR2"/>
    <dbReference type="FunCoup" id="A0A068TVR2">
        <property type="interactions" value="1302"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVR2"/>
    <dbReference type="Gramene" id="CDP00380">
        <property type="protein sequence ID" value="CDP00380"/>
        <property type="gene ID" value="GSCOC_T00032304001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVR2"/>
    <dbReference type="OMA" id="HMPDGYK"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVR2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000010">
        <property type="entry name" value="Protein UXT like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17127" checksum="F0F853402993E3BC" modified="2014-10-01" version="1">MDRVRQEKIQRFEEFVDRRLKPDLVHAIAERHLDKVFEQQKVFSDLKRNIETLENNSVTSLRTLVNLGSEVYMQADVPDTSRIFVDVGLGFHVEFTWSEALQYIAAREEKLDRQIEDYTRLIASIKAQIKMVCEGIRELLQLTEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW77</accession>
    <name>A0A068TW77_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="3 15">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00032482001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
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        <reaction evidence="14 15">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="15">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="3 15"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A068TW77">
        <property type="interactions" value="1658"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TW77"/>
    <dbReference type="Gramene" id="CDP00521">
        <property type="protein sequence ID" value="CDP00521"/>
        <property type="gene ID" value="GSCOC_T00032482001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW77"/>
    <dbReference type="OMA" id="CYQRKNE"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
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    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
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    </dbReference>
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        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
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        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF15">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_decarbox"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 15" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12 15" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8 15" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042322715" description="S-adenosylmethionine decarboxylase beta chain" evidence="20">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042322716" description="S-adenosylmethionine decarboxylase alpha chain" evidence="20">
        <location>
            <begin position="71"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="16">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="16">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="19">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="18">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="358" mass="39449" checksum="73E1380E62C4548C" modified="2014-10-01" version="1">MALPVSAIGFEGYEKRLEISFFEPSIFADPEGKGLRSLTKTQLDEILEPAECTIVSTLSNKYLDSYVLSESSLFVHPYKIIIKTCGTTKLLLSIPPILKLAESLSLTVRAVKYTHGSFIFPGAQSFPHRSFSEEVALLDSYFGKLGSGSKAFVMGDSGQPQKWHVYYASAGSEQSSDPVYTLEMCMTGLDREMASVFYRSQSSSAALMTVQSGIRKILPESEICDFEFDPCGYSMNSIEGDAISTIHVTPEDGFSYASFEAAGYDLKVVNLGLLIARVLACFEPSEFSIAVHADLSPKLLELTCSLDLKGYHLGEKCREELGSDNSVVYQKFVKTVACGSPRSILKCCWKEDEEEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWR5</accession>
    <name>A0A068TWR5_COFCA</name>
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        <recommendedName>
            <fullName evidence="1">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373">
        <property type="entry name" value="OS07G0479600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373:SF28">
        <property type="entry name" value="OS07G0479600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="118" mass="13726" checksum="30670821B45955F9" modified="2014-10-01" version="1">MQTMDATALSCHFHEKMPFEGLTPTNEAKKPVEDNSNSPVFVNHGKFFNSANAWHESRKRWTGDLNQRSIRIEKDPIISWSTTYEDLLSTNEPFPERIPLTEMVDFLVDIWHDEGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXC5</accession>
    <name>A0A068TXC5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00034430001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXC5"/>
    <dbReference type="STRING" id="49390.A0A068TXC5"/>
    <dbReference type="Gramene" id="CDP00960">
        <property type="protein sequence ID" value="CDP00960"/>
        <property type="gene ID" value="GSCOC_T00034430001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXC5"/>
    <dbReference type="OMA" id="NTWPDKN"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXC5"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="403" mass="44550" checksum="795691FB871330C3" modified="2014-10-01" version="1">MHNMCIRPTPEELENFGTPDFTIYNAGQFPCNRYTHYMTSSTSIDMNLDRREMVILGTQYAGEMKKGLFSLMHYLMPKRGILSLHSGCNIGKGGDVALFFGLSGTGKTTLSTDHNRYLIGDDEHCWSENGVSNIEGGCYAKCIDLSREKEPDIWNAIKFGTVLENVVFDEHYREVDYTDKSVTENTRAAYPIEYIPNAKIPCVGPHPKNVILLACDAFGVLPPVSKLNLAQTMYHFISGYTALVAGTEDGIKEPTATFSACFGAAFIMLHPTKYAAMLAEKMKKHGATGWLVNTGWSGGSYGSGSRIKLAYTRKIIDAIHSGTLLKANYTTAEVFGLEIPTEIEGVPSEILNPENTWSDKKAYKDTLLKLGGLFKKNFEVFTNYKIGADNKLMEEIVAAGPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXR1</accession>
    <name>A0A068TXR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029941001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXR1"/>
    <dbReference type="FunCoup" id="A0A068TXR1">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXR1"/>
    <dbReference type="Gramene" id="CDP00133">
        <property type="protein sequence ID" value="CDP00133"/>
        <property type="gene ID" value="GSCOC_T00029941001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXR1"/>
    <dbReference type="OMA" id="NSLACGP"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05329">
        <property type="entry name" value="TR_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045000">
        <property type="entry name" value="TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898">
        <property type="entry name" value="TROPINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="274" mass="29479" checksum="818B27090D55599A" modified="2014-10-01" version="1">MAKVAESSSSSRWSLAGKTALVTGGTRGIGFAVVEELAELGATIHTCSRNAAQLNERLQEWASKGLKVTGSVCDVSSRELREQLMQKVSSVFDGKLNILINNVGTNIRKPTTDYIPEEYSRIMATNLESAYHLSQLAYPLLKASGVGSTVFVSSISGLVHSSSGSIYGAAKGAMNQLTRNLACEWAKDNIRVNCVAPWYIRTPLVENLLSNKEFLDMVISRTPLQRPGEPKEVSSLVAYFCLPAASYITGQVVAVDGGMTVFGFGLPESSNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY50</accession>
    <name>A0A068TY50_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Voltage-dependent anion-selective channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00034769001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY50"/>
    <dbReference type="STRING" id="49390.A0A068TY50"/>
    <dbReference type="Gramene" id="CDP01200">
        <property type="protein sequence ID" value="CDP01200"/>
        <property type="gene ID" value="GSCOC_T00034769001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY50"/>
    <dbReference type="OMA" id="KTIATCR"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000003">
        <property type="entry name" value="Outer mitochondrial membrane protein porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF61">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN PORIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP01200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="277" mass="29685" checksum="60808FB586A5FD0F" modified="2014-10-01" version="1">MSSRGPGLFSDFGKKASDVLTKDYSTEQKFSLSSESDAGVAIASSLAKKGGFSAGVVAAQYKYKKSTVDVKVDTESSIATSITVTDILPSMKTIATCRFPDYNSGKIGVQYFHEHASFTTAVDLNKSPNVDISATIGTPFIAFGTEASYKVDSRSFTTYNAGVSLTKPNYGASVILADKGDAVKATYFHQWDQEKRGVAVAEIARKFSTNVNILTVGASYAIDPHTLVKAKLNNHGNLDTLVQHEMASKSFLILSGSFDTLAMDKQPRFGLALSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYF4</accession>
    <name>A0A068TYF4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-deoxyloganetin glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.324</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00034593001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39899"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18370"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:76849"/>
            <dbReference type="EC" id="2.4.1.324"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.324" evidence="4"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYF4"/>
    <dbReference type="FunCoup" id="A0A068TYF4">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP01082">
        <property type="protein sequence ID" value="CDP01082"/>
        <property type="gene ID" value="GSCOC_T00034593001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYF4"/>
    <dbReference type="OMA" id="MMESISA"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYF4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000027">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000055">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF774">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 85A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="480"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP01082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="652" mass="76566" checksum="D484D4935B7F8791" modified="2014-10-01" version="1">MGSIALLEKKPHAVCIPAAAQGHIGPMLNLAKLLHHNGFHITFVNTEFNHRRLLKSRGPDALNGLPDFQFKAIPDGLPPSDVDATQDIPTLFESMDRTCLGPFRELLAELNDTSSSKVPPVSCIVSDAATGFTLAAAEELSIPEVLFWTSSACSYLGYFQYAKLMEKGIIPLKDASYLTNGYLDTVLDWIPELEGIRLKDLPSFLRTTNPDDFMVKFVLQETQRARKASAIIINTYQQLEHGVLDALSSYLPPIYTIGPLHFLDNHVHYESLTDIQSNLWKEEPECLEWLDSKDPNSVVYVNFGSIAVLTPEQLVEFAWGLANSKQNFLWILRPDLVSGSSAILPSEFLEETKERSMFAGWCPQEKVLSHPAVGGFLTHSGWNSTIESISYGVPLFCWPFFADQQTNCWFCCTKWGIGMEIDNNVKRDEVEGLVSELMAGEKGKEMKKKAMDWKKLAETAVTDSNLNLENLIHQVLLNPKREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREREEKGGGSGWDEEQERSSDGPLLSCSWLRFGPKKLYGPDHFLNLVFNVCGIHKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYL1</accession>
    <name>A0A068TYL1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00034945001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYL1"/>
    <dbReference type="FunCoup" id="A0A068TYL1">
        <property type="interactions" value="2670"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYL1"/>
    <dbReference type="Gramene" id="CDP01341">
        <property type="protein sequence ID" value="CDP01341"/>
        <property type="gene ID" value="GSCOC_T00034945001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYL1"/>
    <dbReference type="OMA" id="EIECAFK"/>
    <dbReference type="OrthoDB" id="1910373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYL1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025397">
        <property type="entry name" value="SDH5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36139">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36139:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14290">
        <property type="entry name" value="SDH5_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26536" checksum="44249E6AF96E89BD" modified="2014-10-01" version="1">MEKTMVLRSLYRAFCRGSLGISSSSSGSAAAVVAAVNHVRHLHLNRPSIPTSSSKPLASDFQNPFTMRIGNARYFSEDVAHTPDIKDSEIECAFKDLMAANWDELPPAVVHDVKKALSKRTDDKSSQEALANMFRAAEAVEEFTGILTSLKMAIDDSIGLSGEDVKPLPKEMADALETVHQRYVAYLGAFGPEEGYLKKKVETELGTKMIHLKMRCSGLHSEWGKVTVLGTSGLAGSYVEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZM3</accession>
    <name>A0A068TZM3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine synthase</fullName>
            <ecNumber evidence="3">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00036606001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="3"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZM3"/>
    <dbReference type="FunCoup" id="A0A068TZM3">
        <property type="interactions" value="1213"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZM3"/>
    <dbReference type="Gramene" id="CDP01522">
        <property type="protein sequence ID" value="CDP01522"/>
        <property type="gene ID" value="GSCOC_T00036606001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZM3"/>
    <dbReference type="OMA" id="GYKCLII"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZM3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000061">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000077">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000098">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="53"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP01522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="427" mass="45498" checksum="D905101E36BF5D9A" modified="2014-10-01" version="1">MAPPLRTTSAIATALSIALLSYLLCKKTRSKASSKKTPKTLSVKKARNGLVAAIGNTPLIRINSLSDATGCEILGKAEFLNPGGSVKDRVAVKIIEEALESGALAQGGIITEGSAGSTAISLATVAPAFGCKCHVVIPDDAAIEKSQILEALGATVERVRPVSITHKDHFVNIARRRALEANQVALKHGKGNQNEYLDVKQINGYTSDSGKQDPIFYSDCKGGFFADQFENLANFRAHYEGTGPEIWDQTGGKLDAFIAAAGTGGTVAGVSCFLKEKNANVRCFLIDPPGSGLFNKVTRGVMYTREEAEGRRLKNPFDTITEGIGINRLTENFKLAELDGAFRGTDLEAVEMSRYLLKKDGLFLGSSSAMNCVGAVRVAQALGPGHTIVTILCDSGMRHLSKFYDVGYLSKYGLMPSAVGLEFLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0G5</accession>
    <name>A0A068U0G5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 90B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00037242001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (22S)-22-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69839"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:1301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:69840"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP02030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0G5"/>
    <dbReference type="FunCoup" id="A0A068U0G5">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0G5"/>
    <dbReference type="Gramene" id="CDP02030">
        <property type="protein sequence ID" value="CDP02030"/>
        <property type="gene ID" value="GSCOC_T00037242001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0G5"/>
    <dbReference type="OMA" id="KLWNLYC"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="term" value="P:unidimensional cell growth"/>
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        <property type="project" value="EnsemblPlants"/>
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    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000061">
        <property type="entry name" value="Cytochrome P450 90B1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
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    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
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    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF194">
        <property type="entry name" value="STEROID (22S)-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1069">Brassinosteroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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            <dbReference type="ARBA" id="ARBA00004167"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="CDP02030.1"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56707" checksum="9F7C19CDD38997D5" modified="2014-10-01" version="1">MSDLEFSLLVLPSILASLLFFHLLLRRNQKSYHLPPGNMGWPLLGENIGYLKPYKATTIGKFMEEHISKYGKIYKSNLFGEPTIVSADAGLNRFILQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRNMRIISLNFLSNARLRTHLLQEVEKHTLLVLGSWKQNSVICAQDEAKKFTFNLMAKHIMSLDPGKPETEQLKKEYITFMKGVVSAPLNFPGTAYRKALQSRSTILQFIEIRMEERIKNECKADDDLLGWVLKNSSLSKEQILDLVLSLLFAGHETSSVSIALAIYFLQSCPKAVQELREEHEEIVKAKKQSQQMELNWDDYKKMEFTQCVVSETLRLGNVVRFLHRKALRDVRYRGYDIPCGWKVLPVIAAVHLDPSLFDQPQHFNPWRWQAGGGSYADGSSTATSNKNFMPFGGGPRLCAGSELAKLEMAVFLHHLVLNYHWELADADQAFALPFVDFPKGLPIRVQQHKPFCVETTPTSPPTFPCKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U129</accession>
    <name>A0A068U129_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039562001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00039562001"/>
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        <property type="component" value="Chromosome IX"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="MYB-related transcription factor"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="Myb_TF_plants"/>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641:SF1376">
        <property type="entry name" value="MYB-RELATED PROTEIN 306-LIKE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00249">
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="247"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="324" mass="35774" checksum="1A2877FBCE1BBD04" modified="2014-10-01" version="1">MGRPPCCDKVGVKKGPWTPEEDIMLVTYVQEHGPGNWRAVPDNTGLRRCSKSCRLRWTNYLRPGIKRGNFTDQEEKMIIQLQALLGNKWAAIAAYLPERTDNDIKNFWNTHLKKKLKKLQTGSDSSSARNALSSSHSISKGQWERRLQTDIKTAKQALHDALSLEGSIPAPDSKPCDGHRSYTEPGQGSSTYASSTENIARLLKGWVKNPSPRKSEQSKSSSTQQSFCNAATDCTSSDGTPSAESKSGIDLSEAFESLFGFESFESSTSEFSQSTSPEASIFQGESKPDQGGAQVPFSMLLENWLLDGKDDLTNFPFEETANLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U268</accession>
    <name>A0A068U268_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00040059001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U268"/>
    <dbReference type="FunCoup" id="A0A068U268">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U268"/>
    <dbReference type="Gramene" id="CDP02616">
        <property type="protein sequence ID" value="CDP02616"/>
        <property type="gene ID" value="GSCOC_T00040059001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U268"/>
    <dbReference type="OMA" id="MDLIDTW"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U268"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000127">
        <property type="entry name" value="Probable glycosyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF46">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP02616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51708" checksum="493EA08CDD9D6714" modified="2014-10-01" version="1">MPKHNSLLRTKTSSFFSSCFLYAAGTSASFLLAWAFWSFFSSPAPSANPSFSRGLASEAALSCPAGKAGHNRSYDPPDPTFYDDPELSYTIEKTIKNWDEKRREWLEKHPSFAAGAADRILMVTGSQATPCKNPIGDHLLLRFFKNKADYCRIHGYDIFYNTVLLQPKMFSFWAKMPAVKAVMLAHPEAEWIWWVDSDAAFTDMDFTLPLDRYKAHNLVVHGWPHLIHREKSWTGLNAGVFLMRNCQWSMDFMEEWASMGPQAPEYDKWGVIQRTTFKDKTFPESDDQTGLAYLILKEREKWGNKIYMEDEYYFEGYWMEIVGTLENITDAYTGIEKRERRLRRRHAERVGESYGKVWEEHLKDAGYGRGSWRRPFMTHFTGCQPCSGDHNQMYSGQSCWDAMQIALNFADNQVLRRYGFVHRDLLDTSTVLPLPFDYPASDLVEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2J7</accession>
    <name>A0A068U2J7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00037004001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2J7"/>
    <dbReference type="STRING" id="49390.A0A068U2J7"/>
    <dbReference type="Gramene" id="CDP01833">
        <property type="protein sequence ID" value="CDP01833"/>
        <property type="gene ID" value="GSCOC_T00037004001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2J7"/>
    <dbReference type="OMA" id="SQEETYG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2J7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF151">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STY17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="294"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="575" mass="65518" checksum="2130467E4B696B7F" modified="2014-10-01" version="1">MAMDDNESCGSRTVETASSKQSRHERQRFEVYTEVLSRLQDLDRQEVKLPGFEDQLWHHFNRLPARYAMDVNVERAEDVLTHKRLLLLAEDPDNRPAFDVRLVQVHPSGAENDLDSAHSDSLMREDAQSHTFESNRRGIHPPPTFGSSSNLEALGVQSSGAHVDDVERDINSIFQTSRPMHEITFSTVDKPKLLSQLTSLLSDIGLNIEEAHAFSTTDGFSLDVFVVAGWPYEETELLKSKLQKEIKMAKEQPSSEQHVPPMTENYERGNPSISEYVKIPTDEIDVWEIDPRQLRFGNRIASGAFGDLYKGTYCSQEVAIKVLKPERVNIDMLKEFSQEVFIMRKIRHKNVVQFLGACTKPPNLCIVTEFMCKGSVHSFLHKQKSTFKLSTIIRVAMDVSKGMNYLHQNNIIHRDLKTANLLMDEHEVVKVADFGVSRVVSQTGVMTAETGTYRWMAPEVIEHKLYDHKADVFSFGIVLWELLTREIPYSDLTPLQAAIGVVQQGLRPAIPKHTHPKLVELLEKCWQQDPTHRPNFSQILENLQRIAKEAVDEVEDRQKDKSIGGFFSSLRKGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2Q7</accession>
    <name>A0A068U2Q7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039836001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2Q7"/>
    <dbReference type="STRING" id="49390.A0A068U2Q7"/>
    <dbReference type="Gramene" id="CDP02454">
        <property type="protein sequence ID" value="CDP02454"/>
        <property type="gene ID" value="GSCOC_T00039836001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2Q7"/>
    <dbReference type="OMA" id="CTHHRAH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2Q7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF1066">
        <property type="entry name" value="METHYL JASMONATE ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="178" mass="20058" checksum="688B8975E659945D" modified="2014-10-01" version="1">MGGVIISLAIEKFPQKIAVAVFLTAFTPAPHLPIRTMAEEYNRRLDSTMDIQHGFENGEDKPPTSLLFGPKFLSTKLYQLSPPEDLALATFLVRPIALFADANLSEVIALTDENYGAARRVYIISDKDNVIKEDLQRWMIEKNPVEEVEEIYDSDHMVMLSRPLELCSCLERIAGKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3Y7</accession>
    <name>A0A068U3Y7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Peptidase M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00041760001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3Y7"/>
    <dbReference type="FunCoup" id="A0A068U3Y7">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3Y7"/>
    <dbReference type="Gramene" id="CDP03245">
        <property type="protein sequence ID" value="CDP03245"/>
        <property type="gene ID" value="GSCOC_T00041760001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3Y7"/>
    <dbReference type="OMA" id="LWNVIGT"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3Y7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000009">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="325"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="573"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="553"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP03245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="78319" checksum="654E670BDF2238AE" modified="2014-10-01" version="1">MNTNVISSFIAIATSISFLLLSPPSKSFYHSLFLSDSLSCNQSIANHLYILTKRPHVAGSEANAEAAAYVLSTLTSYKVRSHITTYEVALTYPISRSLTLKPTPQDSPVKFDLHQEIYDGDPCADVADEVLPTFHAYAKSGTVAGPVVYANYGRVQDYAVLKQMKVNVSGNVVLAKYGKIYRGDIVENAYAEGAIGVLIYTDRKDYGGVGDAKWFPDDKWMPSSGVQVGSVYNGAGDPTTPGWPSSGFCERLSDDDAERGGEVPLIPSLPISWADGDRILRSIDGQVANDDWQGGKDAPVYKVGPGPAILNLSYTGKQVITTIQNVIGIIEGVEEPDRYVILGNHRDAWTFGAVDPNSGTAALLEVAHRMWKLQEKGWKPRRTIIFCNWDAEEYGLIGSTEWVEENREMLASRAVAYMNVDIAVQGLGFYASATPQLDELLIKATKQVQDPDNSSQSIYQSWIRSSENPKIGRLGGGGSDYSAFVQHVGVPATDISYGEDYPVYHSMYDDFIWMKKFGDPKFHRHVAVTSIWGLLALQLADEEFLPFDYLSYANELQRSVEELKIELSEKGIKLFPLFNSIKELRMAATKIANEIKVLQDRNVWASVSKNDHYKVRELNDRLMMAERSFTDREGLPGRTWYKHLIFAPSKHNDYGSKYFPGIDDAIEKAKSINTTDLWLAVQHEVWRVSRVIKHASLVLSGQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4D4</accession>
    <name>A0A068U4D4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041924001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4D4"/>
    <dbReference type="FunCoup" id="A0A068U4D4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4D4"/>
    <dbReference type="Gramene" id="CDP03366">
        <property type="protein sequence ID" value="CDP03366"/>
        <property type="gene ID" value="GSCOC_T00041924001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4D4"/>
    <dbReference type="OMA" id="WDKIIPV"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4D4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000042">
        <property type="entry name" value="probable strigolactone esterase DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="261" mass="28621" checksum="6F2A6B0DD9A0381F" modified="2014-10-01" version="1">MNARLIGSGKETIILAHGYGGDHSVWDKVVPSLAQLHQVLVFDWSFSGAVKDLNLFDAVKYSSYDAFADDIIALVEEMNLKSSVFVGHSMSGMIGCIASVKRPDLFSRLVLVASSPRFINSEDYEGGFEISHIEQIFASIESNYDQWATSFASAVVDNNDPPSVEKLAATLKRMGYKTALPLAKTVFLSDHRAILEKVTAPCTIIHTARDLVVPDSVPIFMQNKIKGPSTIEIIATTEGHFPQLTAHKLFLDVLDKVLIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4T3</accession>
    <name>A0A068U4T3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13 14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00015978001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Phosphatase involved in elongation process, probably by acting as a regulator of brassinolide signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the PPP phosphatase family. BSU subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13 14"/>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03570.1"/>
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        <property type="protein sequence ID" value="CDP03570"/>
        <property type="gene ID" value="GSCOC_T00015978001"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE BSL1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
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    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="649"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="361"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="470"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="883"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="361"/>
            <end position="388"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
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            <begin position="440"/>
            <end position="460"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00022441"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="883" mass="96166" checksum="0A0C3B855143746F" modified="2014-10-01" version="1">MGSKPWLYPAPTYRSLETFWATDDDAPGPRCGHTLTAVAATKTHGPRLILFGGATAIEGGNGGAPGIRLAGVTNSIHSYDVLTRKWIRLRPAGEPPSPRAAHAAAAVGTMVVFQGGIGPAGHSTDDLYVLDLTNDKFKWHRVVVQGQGPGPRYGHVMDLVAQRYLVTVTGNDGKRVLSDAWALDTAQKPYVWQRLNPEGDRPSARMYATASARSDGMFLLCGGRDSSGTPLGDAYGLLMHRNGLWEWTLAPGVSPSSRYQHAAVFVGARLHVTGGVLRGGRAVEGEAAVAVLDTAAGVWLDRNGLVTSSRGSKGHTENDTSLELMRRCRHAAASVGVRVYTHGGLKGDVLLDDFLVAENSPLQSDMNSPVNTPEKTSPRSIQSTSPSHTPAAAMDGEPEALSSGSLSMDRNSMEKLAEASAAEAEVANAVWQAVQAASSTPEETSISGDNPQDADNTSEGSDSEADVRLHPRAVVVAKETVGSLGGMVRQLSLDQFENESRRMVTTHNDLSHPTKKFTRQKSPQGLHKKIISTLLRARNWKAPVNRKFFLDSYEVGELCYAAEQIFMHEPTVLQLKAPVKVFGDLHGQFGDLMRLFDEYGFPSTAGDITYIDYLFLGDYVDRGQHSLETITCLSATGLQIEYPENVHLIRGNHEAADINALFGFRIECIERMGENDGIWAWTRFNQLFNYLPLAALIEKKIICMHGGIGRSINSVEQIEKIERPITMDAGSIILMDLLWSDPTENDSVEGLRPNARGPGLVTFGPDRVTDFCKKNKLQLIIRAHECVMDGFERFAQGQLITLFSATNYCGTANNAGAILVVGRGLVIVPKLIHPLPPPLQSPETSPERMTEENWMQELNIQRPPTPTRGRPQPDLDRNSLAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6B0</accession>
    <name>A0A068U6B0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00016336001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6B0"/>
    <dbReference type="STRING" id="49390.A0A068U6B0"/>
    <dbReference type="Gramene" id="CDP03842">
        <property type="protein sequence ID" value="CDP03842"/>
        <property type="gene ID" value="GSCOC_T00016336001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6B0"/>
    <dbReference type="OMA" id="AVLWERN"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6B0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08301">
        <property type="entry name" value="alcohol_DH_plants"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001292">
        <property type="entry name" value="Alcohol dehydrogenase class-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF35">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="206"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="41296" checksum="E6E75F22B9419491" modified="2014-10-01" version="1">MSSTAGLVIPCKAAVSWEAGKPLVMEQVEVAPPQTMEVRIKIKYTSLCHTDLYFWEAKGQAPLFPRIFGHEAAGIVESVGEGVSDLQTGDHVLPVFTGECKECAHCKSEESNMCDLLRINTDRGVMLTDGKSRFSIDGKPINHFLGTSTFSEYTVVHSGCLAKINPLAPLDRVCILSCGISTGLGATLNVAKPKKGSSVAIFGLGAVGLAAAEGARIAGASRIIGIDLNPNRFEEAKKFGVTEFINPKDHDRPVQQVIADMTDGGVDRSVECTGHIEAMVSAFECVHDGWGVAVLVGVPNKDAVFMTKPINLLNERTIKGTFFGNYKPRTDLPSVVEMYMNKKLELEKFITHRVSFSDINRAFELMLRGEGVRCIINMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6T1</accession>
    <name>A0A068U6T1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016555001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6T1"/>
    <dbReference type="STRING" id="49390.A0A068U6T1"/>
    <dbReference type="Gramene" id="CDP04027">
        <property type="protein sequence ID" value="CDP04027"/>
        <property type="gene ID" value="GSCOC_T00016555001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6T1"/>
    <dbReference type="OMA" id="RYEEFHI"/>
    <dbReference type="OrthoDB" id="1925347at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6T1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010605">
        <property type="entry name" value="DUF1191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512:SF34">
        <property type="entry name" value="MALECTIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF1191)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06697">
        <property type="entry name" value="DUF1191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657381" description="Malectin-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34023" checksum="F522D1D34B9BA34F" modified="2014-10-01" version="1">MLLVAYFYIILWIVPVLRAQSAAELSARSLDSLLQDYAFRALVVRPRTGIVYDGNVPSNLTGIKVAALRLRSGSLRRRGVNSYKEFHIPIGVLEQPYVERLVLVYHNLANWSSLYYPLPGYTYLAPIVGLLAYDAVNLSATNLQELDIRASKDPITIHLPNVQLVPKGLSPKCISFGLDGSFQFDNVINRSACSAAKQGHFSIVVEFTAPAPALAPAPGGGTSRQGGGGEKNNHKVWIIVGSVVGGVLLLLLLCILLACLRKYRRRRNIQRMEEAAERGEPLLMANVGFTKAPVALETRTRPSLEDDYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7B3</accession>
    <name>A0A068U7B3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00015898001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7B3"/>
    <dbReference type="FunCoup" id="A0A068U7B3">
        <property type="interactions" value="2524"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7B3"/>
    <dbReference type="Gramene" id="CDP03503">
        <property type="protein sequence ID" value="CDP03503"/>
        <property type="gene ID" value="GSCOC_T00015898001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7B3"/>
    <dbReference type="OMA" id="YHEKTDK"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7B3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010029">
        <property type="term" value="P:regulation of seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49044" checksum="80777826E351E7F2" modified="2014-10-01" version="1">MEVEQEREPSSSSLSSSSAAMKRFGLKNSIQTNFGDDYVFQIVAREDWTSMAVSLSSNAVKLYSPLTGQYLGECRGHSATVNHISFNVPSSPHILCSSSSDATIRFWDTRTFHQASLSLCALSYMFFVLVSVLWYLDVFLHLSFMFFTSSIYFLEMIKYVVLIVVSFINAGPSEEVFSFSFGGPADNLLAAGCKSQVVFWDWRTMKKAACLEESHMEDVTQVHFVPGHQNKLLSASVDGLMCLFDTSGDINEDDHLESVLNVGTSIGKVGFCGDSNQKIWCLTHIETLSVWDWKESIMEVNFEDARSLTSDRWTLGHVDYFVDCYYSMDENRLWVIGGTNSGTLGYFPLYCKSSQGGASTIGSAEAVLLGGHAGTVRSILPMSRLSGRITQSQGIFGWTGGEDGRLCCWLSDEAFDSNRSFISSALVAKVQKNSRKSRHSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U833</accession>
    <name>A0A068U833_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00016223001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U833"/>
    <dbReference type="FunCoup" id="A0A068U833">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U833"/>
    <dbReference type="Gramene" id="CDP03748">
        <property type="protein sequence ID" value="CDP03748"/>
        <property type="gene ID" value="GSCOC_T00016223001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U833"/>
    <dbReference type="OMA" id="GYLPVFH"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U833"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14231">
        <property type="entry name" value="GAT_GGA-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03561">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46646">
        <property type="entry name" value="TOM1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46646:SF5">
        <property type="entry name" value="TOM1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="50"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="226"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP03748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42658" checksum="DB599CF9B4CEDC51" modified="2014-10-01" version="1">MDKLDKLKMASSSFGERLKTGGAQMSRIVSSKMKEILQAPTPESKMVDEATLETMEEPNWGLNLRICALINSEEFNGTEVVKAIKKKMLGKSPVSQGLSLDLLETCTSNCDKVFSEVASEKVLDDMMKLIDDPKTDHENRVKAMQLIRAWGESEDLMYLPVFHQTYLSLKTRTLPSGLPDGNMPPMQHPLETYMDQDPLSPPESYPMPDTGLHHSENATYNGYAGKSVEEKRESLAVTRNTLDLFSSILNSEDDQKPAKNELTDSMLENCKQSLPVIQGIVESTVDDEGLLFEALSIHDELQQIISRYQQMEDPLVPGGTEPKHGGAGGREPDASGVKGGSSLVQVQNQSETERTEVSKVESGSDNLRSVLLESGGVEGGAKERLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8W0</accession>
    <name>A0A068U8W0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Intimal thickness related receptor IRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00019898001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8W0"/>
    <dbReference type="Gramene" id="CDP05000">
        <property type="protein sequence ID" value="CDP05000"/>
        <property type="gene ID" value="GSCOC_T00019898001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8W0"/>
    <dbReference type="OMA" id="FGENSYT"/>
    <dbReference type="OrthoDB" id="29657at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8W0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054103">
        <property type="entry name" value="CAND6-7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF60">
        <property type="entry name" value="PROTEIN GPR107-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21904">
        <property type="entry name" value="CAND6-7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657430" description="Intimal thickness related receptor IRP domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="CAND6/7 N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="182"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP05000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50780" checksum="D06B4ABB183335A9" modified="2014-10-01" version="1">MASSFSRSSLFFLVGAVIFFFLLNTSLAEIRSTEIRSDSRSTIPFDEFGFTHSGRLNLTVTRISFSKPQLHLSQLGFYLCTRDSWAQVVQQLQDGDIQCPLQSQHIKRVFNFNHLKPDHNPTPYSFEASVKVSDANLFTLLFSNCLPDLEVSMDVHSVMYNFNPKTGQLDFLSAGKTCLPLVYFLFFLAYLAMAAVWVYTLYNNRLTAYKIHFFMLSVVILKALNLLCETEDKSYIKRTGAAHGWDVLFYLFSFLKGITLFTLIVLIGTGWSFLKPYLQDKEKKVLIIVIPLQVVANVAQVAIDETGPFGHNSGTWKKVFLLVDILCCCAVLFPIVWSIKNLREAAKVDGKAAVNLMKLTLFRQYYIIVISYIYFTRVVVYALETITSYNFQWTGPVAAELATLAFYLFTGYNFRPKVQNPYFAIDDEEEEAAAEQLKLEDEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9E8</accession>
    <name>A0A068U9E8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00019542001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9E8"/>
    <dbReference type="STRING" id="49390.A0A068U9E8"/>
    <dbReference type="Gramene" id="CDP04814">
        <property type="protein sequence ID" value="CDP04814"/>
        <property type="gene ID" value="GSCOC_T00019542001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9E8"/>
    <dbReference type="OMA" id="NEQTECM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF499">
        <property type="entry name" value="OS06G0581500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657747" description="Protein kinase domain-containing protein" evidence="19">
        <location>
            <begin position="35"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="517"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="778"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP04814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="847" mass="94141" checksum="97458FB957546BC3" modified="2014-10-01" version="1">MEFGNHTSLRFLLSSVNVLLFLIVAMNLSPNASAARFLSNETDQIALLEFKNKISDPNGVLNSWNHSLHHCQWPGITCDARHQRVTILNLPGKSLFGTISPHVGNLSFLKFFYLEENQFHGDIPQEVGRLLRLRFLNLSSNILTGEIPVNLSHCSELRALSLIRNKLEGRISTELGSLKKLETLQLAVNNLTGEIPSTIGNLSSIKQLSFTFNNLEGNLPEEISLLTTLFFLAMGSNKLTGQVPSTLCNITNLYVLNLSSNNFQGDVTHSLRNCQSLQMLFISQNNFSGSVSPQIFGSYISPTILDLSHNSLSGSLPLEVGKLENIQQLVVSSNKFSGEVPSTLGDCSSMQYLDMQSNLFNGTLPPALASLKGIQFLDLSHNNFSGQIPRDINRLVFLKFLDISYNDLEGEIPTDGVFTNASQIRLVGNSKLCGGIPELQLPSCLVKRKKKGKRLLVLVIPLVLIVILVISVTFFLYHFLHKKRDKSVKESLMMSSDPIEKILRISYHELYRATEGFSSTNLIGSGSFGVVYKGKLDQHQDKEVAVKVLDLQKNGASKSFEAECKALRSIRHRNLLSLLTYCSSIDTKGNEFKALVYEYIQNGSLDMWLHSELAEATRSRNLDLLQRINIAVNVASGLDYLHNHYEVTIVHCDLKPSNILLDNDLIAHVGDFGLAKLLPRTADIDSETLILSKKLPAYGMGLQVSTEGDVYSFGILLLEMFTGRRPTDDAFVDGLDLHNYVKMALPEQVLKIVDPSLLSSEAEENKVVLQAASEDEETNHGKRAVEMNDGDIKSSSDETNNVQKCLILILKVGLGCSQKSPMDRIDMKEVTRELHFIRDAYLGVRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9S6</accession>
    <name>A0A068U9S6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Single-strand DNA endonuclease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Flap endonuclease GEN-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00020182001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9S6"/>
    <dbReference type="Gramene" id="CDP05216">
        <property type="protein sequence ID" value="CDP05216"/>
        <property type="gene ID" value="GSCOC_T00020182001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9S6"/>
    <dbReference type="OMA" id="NKSHCAM"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9S6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009650">
        <property type="term" value="P:UV protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09869">
        <property type="entry name" value="PIN_GEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000030">
        <property type="entry name" value="flap endonuclease GEN-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057340">
        <property type="entry name" value="Chromo_SEND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF54">
        <property type="entry name" value="SINGLE-STRAND DNA ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25386">
        <property type="entry name" value="Chromo_SEND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP05216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="583" mass="64866" checksum="A59A6FEE9FA22946" modified="2014-10-01" version="1">MGVKNLWDILESCKKILPLHHLQNKRVCIDLSCWMVQLQNVNRTHCAMTSKLYLQCLFHRLRALIALNCSLIFVTDGSIPSIKLSTYRRRLNVGSEVNVEETNPKIVSSLRRNMGSEFSCMIKEAKSLGKALGIPCLDGVEEAEAQCALLNSESLCDACFTSDSDAFLFGARTVYRDICLGEGGYVVCYEMADIERNLGFGRNSLITLAVLLGSDYSQGVYGLGQESACQIVKSVGDSAVLHRIALEGISFAQKPKVSKKKARSLSANQERDANGADSNFQKNTEFMEVINAYLKPKCHPPDSDAVYRVLAVYPFNRHQLQQICAQFFDWPPEKTDEYILPKIAERDLRRYASLRSTSSNLGVKVSMDEMPVKCPISSIIKQRKLQGRDCFEVSWEEMHGLNASVVPADLVERACPEKIVEFQERKAQGKKRNHCVSRPKKLGNMPSAEEIDLKLQKLLLDIENESKTTRGASLSGRSKLEKTSALIQADLAIEELHLEDKLEKEPDSVTTTGCKSVAPSPRGTEVINLMSPLPVSAPSSTRQGANVECIDLIELSESETEISPDHARKARDLRLFIASIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBN9</accession>
    <name>A0A068UBN9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00020735001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBN9"/>
    <dbReference type="FunCoup" id="A0A068UBN9">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBN9"/>
    <dbReference type="Gramene" id="CDP05599">
        <property type="protein sequence ID" value="CDP05599"/>
        <property type="gene ID" value="GSCOC_T00020735001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBN9"/>
    <dbReference type="OMA" id="TTILDHE"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057590">
        <property type="entry name" value="PH_RDR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058751">
        <property type="entry name" value="RDRP_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058763">
        <property type="entry name" value="RRM_RDR1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF1">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24823">
        <property type="entry name" value="PH_RDR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26252">
        <property type="entry name" value="RdRP_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26250">
        <property type="entry name" value="RRM_RdRP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDR1/2-like RRM" evidence="11">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RDR1/2-like PH-like" evidence="10">
        <location>
            <begin position="101"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="361"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="13">
        <location>
            <begin position="956"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP05599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1113" mass="127218" checksum="18577A744F9A3CF0" modified="2014-10-01" version="1">MGKTIQVFGFPYVLAAEIVTEFLERFTGQGTVYALEVKQSKGGPRAYARVQFINDRSAEYIIALAEQCLNYGSSYLRAWEMDSDLVPRPRTYEHHMEQIVLNFGCQVSENRFSVLCNVPNVSVRFGIGMRKMYFILHFRSCDYKLELSDENLWQIVLHRRGQAAKFLLIQLLGAPRVFQKLEESTFSYFQETPDDRWLRTTDFTSSCIGQSSGICLKLPRGIKLPNLRDYFPWYKESDSQFTLETGSPYSYNLVLAPILHPPRGLYLPYGILFKVCCLVQNGCLPGPSLDANFFRLVDPQRRDIRYIEHALENLYILNDCCYEPVQWLKEQYDKYDKLLQLPISPTLTLEGGLVYVRRVQVTPCKVYFCGPEVNVSNRVLRHFSEDIGNFLRVSFIDEEGNKMFATDLSPRIAANVNQRTKIYERILSTLKNGIVIGDKKFEFLAFSSSQLRDNSVWMFASRPGLTAADIRTWMGDFSRIRNVAKYAARLGQSFSSSTETLNVGTHEIEMIPDIEVRGGYFGASKYVFSDGIGKISAQFARQVARKCGFITSTPSAFQIRYGGFKGVVAVDPTSSKKLSLRQSMKKYESNNTKLDVLAWSKYQPCFLNRHIITLLSTLGVKDIVFEKKQCEAVSRLDTILTDPLRAHEALDLMASGENMNVLKEMLKCGYKPNSEPFLSMMLQTFRTSKLLELRTKTRIFIPNGRSMIGCLDETRTLEYGQVFVQLSSAGHGQFYDDSNQYSEQNVILEEKVVVAKNPCLHPGDVRILKAVNLPALHHMMDCVVFPQKGKRPHPNECSGSDLDGDTYFVCWDPDLIPPRQDRPMDYTPAPTMQLDHKVTIEEVEEYFTDYIVNNSLGIIANAHTVFADREPLKARSEPCLELAELHSIAVDFPKTGVPAEIPSHLRVKEFPDFMEKSDKPMYDSQRVIGKLFREVKGKAPLTSSIKSFTKQVARKSYDSDMEVDGFEDYIAEAFDYKSEYDYKLGNLMDYYGIETEAEILSGGIMKMSRSFDRRNDAEAVGRAMTSLRKEAKTWFNTNGDHFGDACAKASAWYHVTYHPKYWGCYNKGLNRAHYISFPWCVYDKLIQIKKASIRRSQQISLLELQFSHGLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC82</accession>
    <name>A0A068UC82_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00021558001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC82"/>
    <dbReference type="FunCoup" id="A0A068UC82">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC82"/>
    <dbReference type="Gramene" id="CDP06160">
        <property type="protein sequence ID" value="CDP06160"/>
        <property type="gene ID" value="GSCOC_T00021558001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC82"/>
    <dbReference type="OMA" id="EESSMCV"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC82"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000083">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000035">
        <property type="entry name" value="Putative receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052232">
        <property type="entry name" value="RLK_Ser/Thr-Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984">
        <property type="entry name" value="OS01G0323000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984:SF4">
        <property type="entry name" value="OS01G0631700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="186"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="464"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="509" mass="56972" checksum="68592E420267A9E7" modified="2014-10-01" version="1">MSSESLNAELSKKTSFLGLKLWVVIGLCVGAFIVLILCTLSIWVMFRRRSRRTLDKYSLCQIPNISKDIKVDRVGGQDYHDHPETVYLTVNDKSSDKNSEKMLVHLGRSKSSDVDNLSQCSSMYHHERACSSQSGEEGSSGTARKLSSLPYGLPMASPLIGLPEISHLGWGHWFTLRDLDIATNRFSAENVIGEGGYGVVYRGRLVNGTEVAVKKLLNNLGQAEKEFRVEVEAIGHVRHKNLVRLLGYCIEGVQRMLVYEYVNNGNLEQWLHGTMKQHGTLTWDARMKVLLGTAKALAYLHEAIEPKVVHRDIKSSNILIDDEFNAKVSDFGLAKLLGSGESHITTRVMGTFGYVAPEYANSGLLNEKSDIYSFGVLLLEAVTGRDPVDYARPANEVNLVEWLKMMVGHRRAEEVVDPDLEVKPATRALKRALLVALRSVDPDAEKRPRMSQVVRMLEADEFPYREDRRNRRSRTASMEIESMKDSSGLADVESSVGQSDNQTSDKIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCH6</accession>
    <name>A0A068UCH6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-phosphoglycerate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020348001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCH6"/>
    <dbReference type="FunCoup" id="A0A068UCH6">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCH6"/>
    <dbReference type="Gramene" id="CDP05343">
        <property type="protein sequence ID" value="CDP05343"/>
        <property type="gene ID" value="GSCOC_T00020348001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCH6"/>
    <dbReference type="OMA" id="IYFMDEE"/>
    <dbReference type="OrthoDB" id="271259at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCH6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF2">
        <property type="entry name" value="2-PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51435" checksum="60D21B3CA7CB0F6C" modified="2014-10-01" version="1">MKKGKSVGVVGGPSDGYERDDYPDYDDDDDDELSVMRPRRSSTDARPIVRTPSRGGSSKYDFVKVKVWLGDNADHYYVLSRFLLSRMLTVTKIPNHVAIKIALELKKLLIDNSLLDVSQSDLEANLFKLMKRRGYGAEYINRYKMMTRFHHQRVPLVILVCGTASVGKSTIATQLAQRLNLPNVLQTDMVYELLRTSTDAPLASSHVWARDFSSSEELITEFCRECRVVQKGLAGDLRKAMKDGKPIIIEGMHLDPSIYLMDDDNKLLNQMPTKDEESKPSKGDCKDGIKTVSNSTVSQDSQEENKYSCPGNVTLGEETSADQLIKVSGLIKALDILGINPEKKVETIKDPADDIKEKSGPRPIIIPIVLKMADFDHKALLEEWICTRTSNGKCQIQDKDKLSSNLKTIQDYLCSFKSLGLTVVNISATTFPQTLDWLHNYLLQCIEQGISTSSSGEASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCJ6</accession>
    <name>A0A068UCJ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022999001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCJ6"/>
    <dbReference type="Gramene" id="CDP06265">
        <property type="protein sequence ID" value="CDP06265"/>
        <property type="gene ID" value="GSCOC_T00022999001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCJ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP06265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="9859" checksum="F897140B883CF2F3" modified="2014-10-01" version="1">MTVAVPDKRQFVTFMSWSEIFRLNFGTITDQIVENANFCFFVWVNSLWQTVFINRIVFQFWARWTYCFEAYILGNRWFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD85</accession>
    <name>A0A068UD85_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pyruvate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00023316001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="6"/>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD85"/>
    <dbReference type="FunCoup" id="A0A068UD85">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD85"/>
    <dbReference type="Gramene" id="CDP06456">
        <property type="protein sequence ID" value="CDP06456"/>
        <property type="gene ID" value="GSCOC_T00023316001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD85"/>
    <dbReference type="OMA" id="AQEISVM"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD85"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036293">
        <property type="term" value="P:response to decreased oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000009">
        <property type="entry name" value="Pyruvate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000017">
        <property type="entry name" value="pyruvate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000021">
        <property type="entry name" value="Pyruvate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF6">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="239"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="450"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="603" mass="65155" checksum="29368D3F710D76F3" modified="2014-10-01" version="1">MDTRIGALDTCKPLSNDVGSLPTNGAVTIHQSPISFNSADSTLGRHLARRLVQVGVNDVFSVPGDFNLTLLDHLLAEPGLNLVGCCNELNAGYAADGYARCRGVGACVVTFTVGGLSILNAIAGAYSENLPVICIVGGPNSNDYGTNRILHHTIGLPDFSQELRCFQTVTCYQAVVNNLEDAHEAIDTAISTALKESKPVYISISCNLPAIPHPTFSREPVPFSLSPKLSNQKGLEAAVEAAAEFLNKAVKPVMVGGPKLRVAKACEAFVELADASGYALAVMPSAKGLVPEQHSHFIGTYWGAVSTAFCAEIVESADAYIFAGPIFNDYSSVGYSLLLKKEKAIIVQPDRVTIANGPAFGCVLMKDFLRELAKKLKRNTTAYENYERIYVPEGHPLKCQPKEALRVNVLFQHIQNMMSGDTAVIAETGDSWFNCQKLKLPAGCGYEFQMQYGSIGWSVGATLGYAQAAQQKRVIACIGDGSFQVTAQDVSTMLRCGQRTIIFLINNGGYTIEVEIHDGPYNVIKNWNYTGLVDAIHNGEGKCWTTKVRCEEELIEAIETATGAKKDCLCFIEVIVHKDDTSKELLEWGSRVSAANSRPPNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UED9</accession>
    <name>A0A068UED9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023847001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UED9"/>
    <dbReference type="FunCoup" id="A0A068UED9">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UED9"/>
    <dbReference type="Gramene" id="CDP06836">
        <property type="protein sequence ID" value="CDP06836"/>
        <property type="gene ID" value="GSCOC_T00023847001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UED9"/>
    <dbReference type="OMA" id="VCLELET"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UED9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16128:SF8">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16128">
        <property type="entry name" value="FAD/NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32426" checksum="521B1B8359B80DC3" modified="2014-10-01" version="1">MATITVNFINSNFIPYPFKYQFLSNQNSLLADFLNPRKLITLKIQCCTKTSPNKKPRKPPMDKSNSSKNPNSKRAPNRRRSSTSYGTSRKSVLKKSFSQEQVYFSGPVSNDPVVGIIGGGMAGLICALYLEKRGIRSTVFDTGLHGLGGRMATRIIDPEPLIFDHAAQFFTVTDPEFAKLVHLWSEKGLVREWHGTVGELEAGGHFTPLPSSPPRYIGANGMRPLADTILSQTHLVNVVRPCWVSTLEPFNGMWHLSEKGKNCGQFDAIVIAHNGNHFASKFHLLLLSSPCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEM0</accession>
    <name>A0A068UEM0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00023557001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEM0"/>
    <dbReference type="FunCoup" id="A0A068UEM0">
        <property type="interactions" value="3404"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEM0"/>
    <dbReference type="Gramene" id="CDP06639">
        <property type="protein sequence ID" value="CDP06639"/>
        <property type="gene ID" value="GSCOC_T00023557001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEM0"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEM0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000006">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="293"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="561"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="957" mass="111757" checksum="5FCDDAB4EBAA0FE5" modified="2014-10-01" version="1">MSTFAKPENALKRAEELITVGQKQEALQALHDLITSRRYRAWQKTLERIMFKYVELCVDMRRGRFAKDGLIQYRIVCQQVNINSLEEVIKHFMHLATERAELARSQAQALEEALDVEDLEADKRPEDLMLSYVSGEKGKDRSDRELVTPWFKFLWETYRTVLEILRNNSKLEGLYAMTAHRAFQFCKQYKRTTEFRRLCEIIRNHLANLNKYRDQRDRPDLSAPESLQLYLDTRFEQLRVATELELWQEAFRSIEDIHGLMCLVKKTPKASLMVVYYAKLTEIFWISSSHLYHAYAWLKLFSLQKSFNKNLSQKDLQLIASSVVLAALSVPPYDHSQGVSHLELENEKERNLKVANLIGFDVEPRSEGKEVLSRAGLLAELVSKGVMSCVTQEVKDLYHLLEHEFIPLDLATKVQPLLTKISKLGGKLSSASSVPEVQLSQYVPALEKLATLRLLQQVSQVYQTMKIETLSKMISFFDFAVVEKISVDAVKHNFIPMKVDHMKGAVFFGEQTLESDGLRDHLALFAESLSKARVMIYPPVKKARKLGETLSGLSEIVEKEHKRLLARKSIIEKRKEEQERQLLEMEREEESKRLKLQKITEEAEQKRLATEYEQRKNQRILKEIEERELEEAQALLQEAEKRSKKKGKKPVLEGEKITKQTLMEMALTEQLRERQEMEKKLQRLAKTMDYLERAKREEAAPLVEATFQQRLVEEAAVHEREEQQEIELSRQRHAGDLEEKRRLGRMLENKKLFHDRVVSRREDEFNRLRKESQDRINQIIQTRKQEREIQRKMIYYLRAEEERLRRLREEEEAQQREEAERRRKEEAERKAKLDEIAEIQRQRERELEEKAKKMREEALGKPSSVAPRPADPPAVARPTDPVPTVPAVAAQNTGKYVPRFKRQQSEAAGQAPPPETGGSKLDDRASLPGDRWRDDRRPSYGGGASRPTWSLNRNRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEY7</accession>
    <name>A0A068UEY7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7895 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024163001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEY7"/>
    <dbReference type="FunCoup" id="A0A068UEY7">
        <property type="interactions" value="1320"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEY7"/>
    <dbReference type="Gramene" id="CDP07061">
        <property type="protein sequence ID" value="CDP07061"/>
        <property type="gene ID" value="GSCOC_T00024163001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEY7"/>
    <dbReference type="OMA" id="LERWPYH"/>
    <dbReference type="OrthoDB" id="1933346at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEY7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057217">
        <property type="entry name" value="DUF7895"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37230">
        <property type="entry name" value="OS06G0731300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37230:SF1">
        <property type="entry name" value="OS06G0731300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25433">
        <property type="entry name" value="DUF7895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7895" evidence="1">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="154" mass="16462" checksum="3057C828B1DB68EE" modified="2014-10-01" version="1">MSLRFAARQIKRNSCKVLQRSTYSPSVLKLNQPECRTCRIFCALPETAASIAVAATIVGAAATLLQRRTEASETTEASTKICDDCGGSGVCPECKGEGFVLKKLSEESAERARLMAKNAATRYTAGLPKKWSYCTKCSSSRSCSNCGGTGKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UF32</accession>
    <name>A0A068UF32_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peroxidase</fullName>
            <ecNumber evidence="3">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00023937001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="3"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UF32"/>
    <dbReference type="STRING" id="49390.A0A068UF32"/>
    <dbReference type="Gramene" id="CDP06897">
        <property type="protein sequence ID" value="CDP06897"/>
        <property type="gene ID" value="GSCOC_T00023937001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UF32"/>
    <dbReference type="PhylomeDB" id="A0A068UF32"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31235">
        <property type="entry name" value="PEROXIDASE 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654851" description="peroxidase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP06897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="168" mass="18304" checksum="00DE6215A0C27149" modified="2014-10-01" version="1">MVLLLGVSLYFWKCLLFCSLIQDRLYNFQNTGKPDPSMDSNPVSKPRKRCPKKSGFDQTVNIDQKPPSANTVDDPHYKQIALHRGVLQLDQELALELMTKDTGCDASILLDGSNSEKTAIPNLSVRGYDLIDAAKAAVEGICPGVVSCADIISMAARDAVSMVRATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFT4</accession>
    <name>A0A068UFT4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00024152001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 (TC 3.A.1.121) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFT4"/>
    <dbReference type="FunCoup" id="A0A068UFT4">
        <property type="interactions" value="2797"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFT4"/>
    <dbReference type="Gramene" id="CDP07054">
        <property type="protein sequence ID" value="CDP07054"/>
        <property type="gene ID" value="GSCOC_T00024152001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFT4"/>
    <dbReference type="OMA" id="YLDQHTK"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFT4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000683">
        <property type="entry name" value="Abc transporter f family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="82"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="393"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP07054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="608" mass="67739" checksum="B10A8EA40C258122" modified="2014-10-01" version="1">MVSDASKKRDAQKKAAAAAKRGGKSAAASSKAAKEVAAAAAAATTAAENGSADSLANGVGMLQISDRTCTGVLCSHPLSRDIRIESLSLTFHGHDLIVDSELELNYGRRYGLLGLNGCGKSTLLAAIGCRELPIPDHMDIYHLTREIEASDISSLEAVINCDEERLKLEKEAEALAGQDDGGGEQLERVYERLEAMDAATAEKRAAEILFGLGFTKKMQEMKTRDFSGGWRMRIALARALFMNPTILLLDEPTNHLDLEACVWLEETLKKFDRILVVVSHSQDFLNGVCTNIIHMQGKKLKPYTGNYDQYVQTRAELEENQMKQYKWEQEQIASMKEYIARFGHGSAKLARQAQSKEKTLAKMERGGLTEKVARDKVLVFRFTDVGKLPPPVLQFVEVSFGYTPDNLIYKNLDFGVDLDSRVALVGPNGAGKSTLLKLMTGDLVPLDGMVRRHNHLRIAQFHQHLAEKLDLEMPALQFMIKEYPGNEEERMRAAIGKFGLSGKAQVMPMKNLSDGQRSRVIFAWLAWRQPHMLLLDEPTNHLDIETIDSLAEALNEWDGGLVLVSHDFRLINQVAQEIWVCADQTVTRWQDDIMSFKEHLRQKAGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH35</accession>
    <name>A0A068UH35_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00024872001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/BELL homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH35"/>
    <dbReference type="FunCoup" id="A0A068UH35">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP07577">
        <property type="protein sequence ID" value="CDP07577"/>
        <property type="gene ID" value="GSCOC_T00024872001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH35"/>
    <dbReference type="OMA" id="DARYTHY"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006563">
        <property type="entry name" value="POX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07526">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00574">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POX" evidence="9">
        <location>
            <begin position="222"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="448" mass="50838" checksum="81A178901D9D42B0" modified="2014-10-01" version="1">MSQSFHQGIYSFSNGYERSPTTTKQGMEWISQRVQNFELQQQQQVQTEVNSGEPQVYDDTGGGMLTEMIDFSRGRGKSANHLLLDGQIPSSYRWSQKQQLPLTVVNEAELLLMNPLHVKASSSSPTSTSSLHMSVPNSSDSHHPSLHLQEYHLENPSQFSWVRVNGNEVGDDNTKIGRAMEAQGLSLSLSSSMPNLEAAKFQELRPGDGGVYFFDQGVGPSMNFTRKVKTLGRFLLLRMLVEGQFHQLAPRTARLYQLLKRRSTKGRRSSSCPCLMRHVDARYTHYCEQMQAIVHSFDSVIGYGAAAPYTNLAQKAMSRHFRSIKDAILGQVKVTCELLGDKDVNGTIGLTKGETPRLRLLEQKFRQQKALHQLGMLDPETWRPQRGLPERSVNILRAWLFEHFLHPYPSDADKHLLSRQTGLSKNQEHQLCLKHERLEVPHMLSQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHF2</accession>
    <name>A0A068UHF2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00025387001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHF2"/>
    <dbReference type="FunCoup" id="A0A068UHF2">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHF2"/>
    <dbReference type="Gramene" id="CDP07896">
        <property type="protein sequence ID" value="CDP07896"/>
        <property type="gene ID" value="GSCOC_T00025387001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHF2"/>
    <dbReference type="OMA" id="ISDICTW"/>
    <dbReference type="OrthoDB" id="532289at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHF2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034568">
        <property type="entry name" value="MED30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36406">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36406:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="21784" checksum="BF3355CF179275A1" modified="2014-10-01" version="1">MEDKAGTAGAVAVAGKTIQELAVEGQKHLEETIESAFQILSSMNDELCNPNLWSTNPNPNSSTAGAAASAAIANGIVNNGSTSAMSNGHHTASNGDVSSDSSSSSSHQLDIGVGVGALEDARMRYKSSVASLRSVLTAISNSQKVKASEMVSTSGSGSPTDQADIEKLEEQASALRKALVERNKYLKLLIDQQRDLISDICTWQSPCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIJ3</accession>
    <name>A0A068UIJ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00027165001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIJ3"/>
    <dbReference type="FunCoup" id="A0A068UIJ3">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIJ3"/>
    <dbReference type="Gramene" id="CDP08360">
        <property type="protein sequence ID" value="CDP08360"/>
        <property type="gene ID" value="GSCOC_T00027165001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIJ3"/>
    <dbReference type="OMA" id="NRWDHVA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIJ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000144">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000553">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001074">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF410">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="584"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP08360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="676" mass="76682" checksum="37DD92BC55D980AC" modified="2014-10-01" version="1">MRSPRLRIRNEPFSFPFFRTFPRFIFLRYFSSSYLPAVENSDAFPKPTTLQSTPSPAPLHKLHLVPPCNLAPCDQRQMNYAVSMNKKITSFVRCGDLDSALKLFYKMAFRTTITWNSILAGFSRKPGKLKEAQQWFVKIPEPDTVSYNIMLACYLQNGELEAAGNLFSQIPCKDVASWNTMIAGFSRNGMMSEAKNLFLAMPRKNNVTWNAMIAGYVESGNVELALEMFQANPAKDVIAYTAIVTGFMRSGKVDFAEKMFLEMPVKNLVTWNAMISGYVENGRGEDGLKLFRTMLELGIRVNESTLSSILLGCSNLSFLKLGKQVHQHVFKSPLYLDITVGTSLISMYCKCGDLEDAWKLFLEMPRKDVVTWNAMISGYAQHGAGEKALSLFSKMRNNGGMRPDWITFVGVLTACNHAGLVDLGIQYFELMQKDYGVKPQPDHYTCMVDLLSRAGKLAEAMDLIKRMSCRPHMAVFGTLLGACRIYKNLEVAEFAGKNLLSLDPTNAAAYVQLANLYAANNRWENVSIVRRLMKENKVIKTPGYSWMEIKNVVHEFRSGDRLHPELDSIHEKLNELEKKMKLAGYVPNLESDLHDVEKQQKEQILLLHSEKLAIAYGLISLPPGEPIRIFKNLRVCDDCHQATKFISAIEPREIIVRDTTRFHHFKDGMCSCRDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIQ4</accession>
    <name>A0A068UIQ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00026809001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIQ4"/>
    <dbReference type="FunCoup" id="A0A068UIQ4">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIQ4"/>
    <dbReference type="Gramene" id="CDP08089">
        <property type="protein sequence ID" value="CDP08089"/>
        <property type="gene ID" value="GSCOC_T00026809001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIQ4"/>
    <dbReference type="OMA" id="VYPIEPS"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIQ4"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1150:FF:000001">
        <property type="entry name" value="Acetolactate synthase small subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008864">
        <property type="entry name" value="PRK11895.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239:SF0">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="506" mass="55441" checksum="275400A98BA35AA6" modified="2014-10-01" version="1">MAAVSAQPSFQTINSLKQPSFATIDSSSNASSSNSSRILHVGCFSNPSSSPQRLLLKKTPSFSTQQHPPRLLVSANSTSSSIDSNSFSVSVSPPSTTRPKVRRHTISVFVGDESGMINRIAGVFARRGYNIESLAVGLNKDKALFTIVVCGTDTVLQQVMEQLQKLVNVIKVEDISKEPQVERELMLVKINSDPDYRAEVMWLVDTFRAKIVDLSDYSLTIEVTGDPGKLVAVQRNLSKFGIREIARTGKIALRREKMGESAPFWRFSAASYPDLEGTMSPDAVLRAAKRIRDEKSDTSTGGDVYPVEAADDFYISPVLDAHWGVLDDDDTSGLRSHTLSMLVNDTPGVLNIVTGVFARRGYNIQSLAVGHAEVEGLSRITTVVPGTDASISKLVQQLSKLVELHEVRDLTHMPFAERELMLIKIAVNAAARRNVLDIASIFRAKAVDVSDHTITLELTGDLDKMVALQRLLEPYGICEVARTGRIALVRESGVDSRYLRGYSYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIU3</accession>
    <name>A0A068UIU3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024840001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIU3"/>
    <dbReference type="Gramene" id="CDP07548">
        <property type="protein sequence ID" value="CDP07548"/>
        <property type="gene ID" value="GSCOC_T00024840001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIU3"/>
    <dbReference type="OMA" id="DESHIYI"/>
    <dbReference type="OrthoDB" id="1916003at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIU3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF61">
        <property type="entry name" value="UBIQUITIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="103" mass="11762" checksum="54F93D09D799FA2F" modified="2014-10-01" version="1">MRLVVEILTGRLFFVEIQDDATVADLKKEIGFQEQLPFDRLILLVDGTEGFLMNENERSLQDYGIKDGSHVYLFFDSVDDGSWHCLVAPQDSTWCHTSPPIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ50</accession>
    <name>A0A068UJ50_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024968001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ50"/>
    <dbReference type="STRING" id="49390.A0A068UJ50"/>
    <dbReference type="Gramene" id="CDP07648">
        <property type="protein sequence ID" value="CDP07648"/>
        <property type="gene ID" value="GSCOC_T00024968001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ50"/>
    <dbReference type="OMA" id="GAKHEHA"/>
    <dbReference type="OrthoDB" id="1858978at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1320.10">
        <property type="entry name" value="Outer-capsid protein sigma 3, large lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025521">
        <property type="entry name" value="Neprosin_propep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF110">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14365">
        <property type="entry name" value="Neprosin_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="1">
        <location>
            <begin position="110"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="40560" checksum="98C4DADB01CC7B23" modified="2014-10-01" version="1">MHGYCKWQSPDGDTIDCVDIYHQPAFDHPLLKNHTIFMRPSYIPILDGESKMFNFTTDSQEDSEQVTQPWQLNGECPDGTIPIIRTKKQNFLRASSIKSIPHQFSAHTQITDGAKHEHAVAYVRNEIFYGATATINAWKPQVQSRDERSLAGIWITGGFYGLQANGIQAGWMVSPGLFGDSNARLFTYWTTDSYNSSGCYNLLCSGFVQVSKTLALGAAIHPTSTYHGSQYIITISMWKDQKTDAWWLAFGRHTHIGYWPASLFTTLAATATGIQWGGEVISRNKMGQHTTTQMGSGHFAEEGFRGASYFRDLRVLDSNNVVNPPDELGNAADSPNCYNIKVGHSKTWGDFFYYGGPGKNPKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULL4</accession>
    <name>A0A068ULL4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00028797001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULL4"/>
    <dbReference type="FunCoup" id="A0A068ULL4">
        <property type="interactions" value="3075"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULL4"/>
    <dbReference type="Gramene" id="CDP09435">
        <property type="protein sequence ID" value="CDP09435"/>
        <property type="gene ID" value="GSCOC_T00028797001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULL4"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULL4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="256" mass="29329" checksum="A7759CA13190BD67" modified="2014-10-01" version="1">MDIEQKQAEHIDYFVKQASNQKGPALASVITEATSHPSLFAFSEILSVPTVLELQGTEHSVYLELLRLFAHGTWSEYKSVADRLPHLLPDQVLKLKQLTVLTLAETNKVLPYEGLMQELDVSNVRELEDFLINECMYVGIVRGKLDQLRRCFEVQFAAGRDLRPGQLGNMIQTLSNWLVTSDDLLVSIQEKIKWADTMSELDKKHGKEVEEKVEEVKKSLKADIDFRGHEEIYSEGGMMDYEEDRGRPKRRRHPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULP9</accession>
    <name>A0A068ULP9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028398001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULP9"/>
    <dbReference type="FunCoup" id="A0A068ULP9">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULP9"/>
    <dbReference type="Gramene" id="CDP09177">
        <property type="protein sequence ID" value="CDP09177"/>
        <property type="gene ID" value="GSCOC_T00028398001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULP9"/>
    <dbReference type="OMA" id="MESIWRI"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd13276">
        <property type="entry name" value="PH_AtPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="146" mass="16657" checksum="B103455A93849FFB" modified="2014-10-01" version="1">MESLWRSVTGANPDPSDYAGVEFWSNPERSGWLTKQGEYIKTWRRRWFVLKQGKLLWFKDPFDSSTSSAIPRGVISTADCLTVKGAEDALNKPFSFELSTSRDTMYFVADSDKEKEDWINSIGRSIVQHSRSVTDSEVIDYDSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULT2</accession>
    <name>A0A068ULT2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028784001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULT2"/>
    <dbReference type="FunCoup" id="A0A068ULT2">
        <property type="interactions" value="1568"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULT2"/>
    <dbReference type="Gramene" id="CDP09426">
        <property type="protein sequence ID" value="CDP09426"/>
        <property type="gene ID" value="GSCOC_T00028784001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULT2"/>
    <dbReference type="OMA" id="PPYVYLC"/>
    <dbReference type="OrthoDB" id="1929023at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULT2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36025">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (DUF3598)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36025:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (DUF3598)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57385" checksum="1D789E91FDA1D5F7" modified="2014-10-01" version="1">MQSPCINACKTITGFTHQHHAFYPSSFPSSTSFSSARKFNSYPSISCNFDGNDRKLNDRRRLILVKQAAAGGKENVWSVDNEMAEAEKEKGKMKRRKKKRRGVADGRKRNVGNRNSRFMVSGAMLVEVETVLQTQEPVIRPAWHTFASSLSGIWKGVGAVFSPFTAEMEPIDIGNKNENLFDCYTLSRVEAVPSASGEQTTQIKRRINWVTLNPYGEIPQLNEGEYMRHARSDNGQASLSRKETSNKFSTHNLPKFEAFNFGRSDIMEEDVMGIEPGLVFFEDGSYSRGPVDIRVGEFDESKYFLSPTYKFEQCLVKGCHKRLRIVHTIEFGNGGSDIQIMRVAVYEEQWDGPASIPDESELEVDLQPFSQRERVQPSELIGSWKVFEVSATPIYGEDIMLEESHGAPYVYLCTETLKKRSLPEHSVYFGEEEMLDMQDVTILWLPGGVTGYVDVNKDGILCVGVGWYSDEGINLVMERDYGTDGKLKEVRWKSEMKRRWSNPPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM24</accession>
    <name>A0A068UM24_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00027692001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM24"/>
    <dbReference type="STRING" id="49390.A0A068UM24"/>
    <dbReference type="Gramene" id="CDP08653">
        <property type="protein sequence ID" value="CDP08653"/>
        <property type="gene ID" value="GSCOC_T00027692001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM24"/>
    <dbReference type="OMA" id="QAWQGIF"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM24"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF324">
        <property type="entry name" value="LACCASE-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103918" description="Laccase" evidence="13">
        <location>
            <begin position="30"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="172"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="451"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP08653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="579" mass="64312" checksum="13D1ECDC63CC3045" modified="2014-10-01" version="1">MANPLATSGILYLWLNLLIMNAHRMSVMGFIARWPGGRSTRSYDFKVQTTKIEKLCNTWDIVTINGMFPGPVIYAQEDDRVIVRVTNETPYNATIHWHGVRQRLSCWSDGPSYITQCPIQSGQTFTYEFTLVQQKGTLLWHAHFSWLRATVYGAIVVYPKTGVPYPFIYPYEEHIILLGEFWLRDLVQLEQSVIASGGGPPPADAYTINGHPGPNYNCSTNDVYKIDVVPGKTYLLRLISASLNTEHFFAIANHKLTIVEADAEYTKPFTTDHVMLGPGQTLNVLVTANQPIAKYSMTMGPYMSARNVPFQTITSTAYFQYLGALPNSLSSPAPVPTFNDNLAVKTVMDGLRSLNGTPSVPKEIDQNLFITIGLNVQKCTSRNPQQNCQGLNGGVMAASMNNISFIKPNISLLEAYYRKINGYFTEDFPGAPFKFYDFVNGAPNNAPVDTNSLNGSRTYVLEYGTRVQLILQDTGTVTTENHPIHLHGFSFHVIGYGTGNYNPDTANFNLVDPPYLNTIGVPVGGWAAVRFLADNPGVWFMHCHLEIHLSWGLSVVFIVKNGQGPLQTLPHPPADLPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM77</accession>
    <name>A0A068UM77_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00027727001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM77"/>
    <dbReference type="Gramene" id="CDP08678">
        <property type="protein sequence ID" value="CDP08678"/>
        <property type="gene ID" value="GSCOC_T00027727001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM77"/>
    <dbReference type="OMA" id="KDMVEFK"/>
    <dbReference type="OrthoDB" id="774871at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM77"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009902">
        <property type="entry name" value="DUF1442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33593">
        <property type="entry name" value="DUF1442 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33593:SF1">
        <property type="entry name" value="DUF1442 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07279">
        <property type="entry name" value="DUF1442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP08678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26819" checksum="E27B9EFF332FDE71" modified="2014-10-01" version="1">MEWSAKYATNAYLDALKLCGKHRENCNPGECQKEPESTEFISALAAGMRAQLMVEVASEVSPSTVALAAAARQTGGKLVCILPEVKENKSQQLIEESGLNDMVEFETGDPVDVLHNYENIDFSLIDCTSDNYKKLLDQLDVNPRRSVVVANNLVEGCKGLEGHLRGVEKEAKVRSIKYPIGKGMEITLIGKFSDHNKREKGRGSLSRAEKKGGIVKKTDKSKWIVKVDEKSGEENFYRLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMA8</accession>
    <name>A0A068UMA8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pectinesterase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028723001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMA8"/>
    <dbReference type="FunCoup" id="A0A068UMA8">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMA8"/>
    <dbReference type="Gramene" id="CDP09379">
        <property type="protein sequence ID" value="CDP09379"/>
        <property type="gene ID" value="GSCOC_T00028723001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMA8"/>
    <dbReference type="OMA" id="DKRIQMG"/>
    <dbReference type="OrthoDB" id="1915198at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMA8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15795">
        <property type="entry name" value="PMEI-Pla_a_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000002">
        <property type="entry name" value="Putative invertase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034088">
        <property type="entry name" value="Pla_a_1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357">
        <property type="entry name" value="OS02G0537100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35357:SF17">
        <property type="entry name" value="PECTINESTERASE INHIBITOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658079" description="Pectinesterase inhibitor domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="5">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP09379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="206" mass="23257" checksum="5DF79E0616D7B3E6" modified="2014-10-01" version="1">MRPSISSALLITLFLLCFIHGATSQENLIRESCRTFAKDDPNINFNFCTTSLQAAPASHCAALRGLGTISFRLIRYNVTDTRCMIRQLLKGKKLDPYVRQCLNDCFELYSDAIDTMKQAMKAYNTKRFADANIEISSIMDAATTCEDGFNERKGVLSPLTKRNNNTFELSAIALNVMRILQTRLSLHQLKMPLQQTFSVQLACDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMK2</accession>
    <name>A0A068UMK2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028938001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMK2"/>
    <dbReference type="STRING" id="49390.A0A068UMK2"/>
    <dbReference type="Gramene" id="CDP09532">
        <property type="protein sequence ID" value="CDP09532"/>
        <property type="gene ID" value="GSCOC_T00028938001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMK2"/>
    <dbReference type="OMA" id="TVMSCHI"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP09532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="133" mass="14169" checksum="8DA7B64ED6E6B56F" modified="2014-10-01" version="1">MQVVKESSSIPMDKPGESHSLGLRMESIYEKVRLLASGNAVVIFTMSGCCMCHVVKQLLFGLGVAPTIVELDHDAAGREIHSLLLQLSGKTQQQPVPAVFVGGKFLGGIETVMACHINGSLVPLLKDAGALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN43</accession>
    <name>A0A068UN43_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028229001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN43"/>
    <dbReference type="FunCoup" id="A0A068UN43">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN43"/>
    <dbReference type="Gramene" id="CDP09048">
        <property type="protein sequence ID" value="CDP09048"/>
        <property type="gene ID" value="GSCOC_T00028229001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN43"/>
    <dbReference type="OMA" id="FPLMISD"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF228">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="260"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="724" mass="80141" checksum="71C666B56DA6FECC" modified="2014-10-01" version="1">MGNGIGKLSVCFTCADGGAYEAPRKRDLAAVISDPLDDLGHSFCYVRPDQTRLSSSKVHSEETTASTTTFKSISGASVSANTSTPLSTAFVDVYTYNSIDRASAAAAFESSTSFASIPLQPIPRNSAGYSGPLSSSGLIPGSGPIERGFLSGPIERGFMSGPLDRGLFSGPLEKGFSDQFQRSFSHGGFAFRPRSRKGSLIRALQRALSKTISRGQNSIVAPIKGVVSLKENEWIVDSEKQNELTISSVNLSSEGSLDDDDSSESQNLQWAQGKAGEDRVHVVVSEEHGWVFVGIYDGFNGPDAPDYLLSNLYSAVHKELKGLLWDDKFDSLTKSSSASVETLNSGMEDLNQISKEEVSRDRTKDGCSRGVEQESYPCGNGEVTFDSQISKKTRKSSKGKYRGAAKRWEENQRKWRCEFDKERLELDRRLKEQLNKNRLNGSGTINHSDVLKALSQALKKTEEAFLDLADKMVMENPELALMGSCVLVMLMKGDDVYVMNVGDSRAVLAQKKEPDLWSQDLERINEETLHDLEVDGDISNTVPSLSAFQLSMDHSTSIEEEVQRIRSEHLDDACSVMNDRVKGSLKVTRAFGAGFLKQPKWNDALLEMFRIDYIGTSPYINCLPSLYHHTLGPRDKFLVLSSDGLYQYFTNEEAVSEVELFIAWSPEGDPAQHLVEELLFRAAKKAGMDFHELLEIPQGDRRRYHDDVSIIVISLEGRIWRSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNM0</accession>
    <name>A0A068UNM0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00030405001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNM0"/>
    <dbReference type="STRING" id="49390.A0A068UNM0"/>
    <dbReference type="Gramene" id="CDP09912">
        <property type="protein sequence ID" value="CDP09912"/>
        <property type="gene ID" value="GSCOC_T00030405001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNM0"/>
    <dbReference type="OMA" id="DLWSFAG"/>
    <dbReference type="OrthoDB" id="1919458at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNM0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000003">
        <property type="entry name" value="NAC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF230">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP09912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="325" mass="37670" checksum="3EF2184F117B5D41" modified="2014-10-01" version="1">MNTFSHVPPGFRFHPTDEELVDYYLRKKIASKRIDLDVIKDVDLYRIEPWDLQELCKIGTEEQNEWYFFSHKDKKYPTGTRTNRATKAGFWKATGRDKAIYSKHSLIGMRKTLVFYKGRAPNGQKSDWIMHEYRLETNENGTPQAKGWVVCRVFKKRLTTVRKEGDLESLCWYDDQVSFMPEFDSPRRIPQSYSSYNPQYSCKQEFELQNNIPQDVFLQLPQLESPKVPQSITNVSCIYINNTDQGVEQVTDWRVLDKFVASQLSHEDAAKQTAYSDGPSSLQVAEHMNMLVNDESKQQEMTSPEFGCVSAPSPQVIFGSKNMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNX5</accession>
    <name>A0A068UNX5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00030562001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNX5"/>
    <dbReference type="FunCoup" id="A0A068UNX5">
        <property type="interactions" value="1454"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNX5"/>
    <dbReference type="Gramene" id="CDP10022">
        <property type="protein sequence ID" value="CDP10022"/>
        <property type="gene ID" value="GSCOC_T00030562001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNX5"/>
    <dbReference type="OMA" id="PEHFTIV"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNX5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000061">
        <property type="entry name" value="Methylglutaconyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56099" checksum="F10B1ED8D34AE99E" modified="2014-10-01" version="1">MIDHGKGLAEGFELSIQNGKSPIDALNAKFNAEHSHMMLNIKSRSGSKMGNSPHKAIQSRVPIEESDKPEHFTIVTTTRPPTENLEYLVNQKPENEALGGQENKENARTGFAENGFISMRRSKVGDGENSCKGPLAGESYSSRNGATVPPRGNKEATATRKILLDTTNFQAPNLLEVTGKWRCPQKSKPNLGPPLKQLRLEQWVRRQWLKQKSKPISSSQQLLFHLKKFNINPHQEWNRQSVRTLILQSTSDSVKLHKLDDSDSGVVEVNLDRPGAKNAISKDMLHGLQRSLEAVYKDHSAKVLMICSSVHKAFCAGADLKERKTMTPDEIQNYVNSLRSTFSFLEGLHIPTIAVVEGAALGGGLEMALSCDLRICGEDAVFGLPETGLAIIPGAGGTQRLPRLVGKSLAKEIIFTGRKIGARDALSMGLVNHCVPAGEARSKALEIARDINQKGPLAIRMAKRAIDGGLEMDIASGLSVEMDCYQQLLNTKDRLEGLAAFAEKRRPSYNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPI6</accession>
    <name>A0A068UPI6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00028958001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPI6"/>
    <dbReference type="FunCoup" id="A0A068UPI6">
        <property type="interactions" value="1980"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPI6"/>
    <dbReference type="Gramene" id="CDP09543">
        <property type="protein sequence ID" value="CDP09543"/>
        <property type="gene ID" value="GSCOC_T00028958001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPI6"/>
    <dbReference type="OMA" id="MEHAVGK"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPI6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01766">
        <property type="entry name" value="Ubl_UFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF9">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038027">
        <property type="entry name" value="Ubiquitin-like_Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP09543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="98" mass="10385" checksum="3580FA4308FAB7BB" modified="2014-10-01" version="1">MASGGPGGKVSFKVTLTSDPKLPFKVFSVPEAAPFTAVLKFAAEEFKVPPQTSAIITNDGVGINPQQSAGNVFLKHGSELRLIPRDRVGAHRDLVNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQT6</accession>
    <name>A0A068UQT6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Agenet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030500001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068UQT6">
        <property type="interactions" value="1509"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQT6"/>
    <dbReference type="Gramene" id="CDP09978">
        <property type="protein sequence ID" value="CDP09978"/>
        <property type="gene ID" value="GSCOC_T00030500001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQT6"/>
    <dbReference type="OMA" id="YWKSDQV"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQT6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009934">
        <property type="term" value="P:regulation of meristem structural organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055274">
        <property type="entry name" value="SWO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48429">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48429:SF1">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agenet" evidence="2">
        <location>
            <begin position="1693"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet" evidence="2">
        <location>
            <begin position="1784"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1953"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2155"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1629"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2045"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2115"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2166"/>
            <end position="2176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2176" mass="233010" checksum="657790515943928A" modified="2014-10-01" version="1">MDNEDNVYQGQGFQLVGEENSKVSPVLRPYALPKFDFDEGHLRFDSLVENEVFLGIPSQEDNQWIEDFSRGSSGIEFSSSAADSCPIPRHNNVWSEATSSESVEMLLKSVGQEEMIPGESTIKKSDAGDEFPSIPNQMDDKIDKIEDSNLELPPAEVVGKFSELSENPGVEDACGKSTSPVKEVHFLAHASSGATSEKSSIVVTDENLSIDMKSLDENQREICTSVNESLNEKMQQDPSISEVEVQHAECLAKDVPVSVEKLSNQSMASDVHLESATGSTDNRSEDCSIKDNVSVMDDQKFSEISAETCVTGLRCPHQVDSNVEAVEKCAAEVTASDLDEPSRLPPVGNSDLLTDEGCNEEVCSLQPAQADSFSEGMEIRLQFESRSMLVEKSLVTCQSSDGIVDECPVGARDTKTNVISSEKVCDVQISHENSNLVNKNDDHIGSTSHTDIGSSVIEMETPMVSEMQFESSKHSEQVVKHADDVTVLEQTSTTVGEDCGVISVDTKHGNDAAGVHNEDSSDAAYVVPPRQAGSADFSGEVLSSMQVDVHDYVQVVSIQEKGGEEMTSDSGKMDHDSVESFDDGKVVGSSPLAETGENVETASRTEIDASVTKEKDSKCEVEGADQISPDTVVGVPLLSVAATTKVADQSMEQKSDQFEGKRGMQMEAPIDAGRSLLGEPVEEATQQHPDAVAKAVRTEDLVAEAASDEANASASLILAETSAAASNVEQVVAERASVELLVHCQPNAKEGEGGDVVENLNPDEPQKEKKRVAASSEVQGGSISPAIEKPDDTSDGIGVPELSECEMNKQAGVTGGMTKNFPPSDCKERNDGDTSSSDVALQVNVASKDEGSFAFDVSPLERLPEGGTSKGWQSDPHIQAHKRSTVVDKFPSTSGGSQVDPIVVQEISHGSQQTPDKGAPPQAAKGTSERKTRRSSAKSGKENARKGNPLKETAPLKHSERGDRLSAPIGSAGSCQLKQLEVTSVERSGAKQGVVLPVSVSSLPDLNTSAQVSLFFQQPFTDLQQVQLRAQIFVYGSLIQGVAPDEACMVSAFGMCEGGRSFWEPAWRACLERLHGPKLHPGSSETPVQSRSGPKTAEQGNIQGLSQSKVLSTPAARVSSKSGPSPVVNPMIPLSSPLWNIPTPSCDALATNNMVRGPVLDYQVLSPLHAYQTPPMRNFAGNTTSWASQPPFPGSWVSSAQSSAVDVSARFPPIPLTETVKLTPIKESSVSVSSTTKLASPDPTAHDLKKVSGSHGPHSSDPKSRKRKKTSATEDIGQKSVPVTQTGSAVPAFNNDASRKVHAVEDLGQGVMVPRHHTELVPAPAGTNISTSVANTTPSNFVLKSSSDKPLTTVLSVSTIDHPKGGESLPEKRPLKPEDIAKVEEAKLQAEEASAHAAIAVSHCQNIWCQLEKHNNCGLTADVEAKITSAAVAIAAAASIAKAAAAAAKIASNVALQAKLMADEALISSGTQHPTQVNLQSVPGFVNNVGNATPASILKVGDGNNGSSSIIFAAREAARKKIEAASAASRHAENLDAIVKAAELAAEAVSQAGKVVAMGDPLPISKLVEAGPENYWKGTKLPSGQGAKSNMVGNKSSINSVEEAADVVLDHSVKEVHTRNNGVSPFPKETSKENHNKGGEGISAIDTRVEKDFRGQKSRRASDSRKATDDVHEAVIGSRSMADENMIVTFNDNGIKESSLVEVFKDNGDFTGAWFSANVLSLKDGKALVCYTDLESDEGSAKLKEWIPLEAEGSKQPRIRLAHPMTSITSEGTRKRRRAAARDYTWSVDDRVDAWIENCWREGVIIEKNKKDETTLSVHFPAQGKTSVVRAWHLRPTLVWKDGEWIEWANFKESLQGDTPQEKRIKLGSPPVEGKGKSKISKNVDYAESGKPEDSRLLPLSASDKVFNVGSTRNENKPETLRTVRSGLQKEGSKVIFGVPKPGKKRKFMEVSKHYVSDRSIKSNASNDSEKFTKYLMPQGPGPRGWKSSSKIDSKEKQTAEFNKHRGLKSGKPPGLSARTLPQRENSVVSLAASKDASLTDDLAKNSTSNDENDSGQQNLIDFVSSSNVEETAEEPISSSSQVPPPEFPRRAATLGTKSERLKKGKPPPAGGKSAKVELKDKPIPEAVEPRRSNRRIQPTSRLLEGLQSSLIVSKIPSVSHDKSQRSHNRAVSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URB0</accession>
    <name>A0A068URB0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00030755001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URB0"/>
    <dbReference type="STRING" id="49390.A0A068URB0"/>
    <dbReference type="Gramene" id="CDP10138">
        <property type="protein sequence ID" value="CDP10138"/>
        <property type="gene ID" value="GSCOC_T00030755001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URB0"/>
    <dbReference type="OMA" id="AQYERIP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URB0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP10138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="314" mass="35797" checksum="C98EEA9A9D21293A" modified="2014-10-01" version="1">MGSQSQANLPIVYFTRETLKPGTGSWLSTCKKVRDALEKHSCFLAQYERIPSELISAIFLQLGELFDLPTETKVQNITTTDGLFGYFGQQPTNPTYEGMGIEDVNNPEAVLKFTNLMWPSGNDSFCELMESYKNHVSDLEKLVMRTIFESFGVEKLYSSHDESCNRMLRFNKHRPPQMSENLGGVPEHTDPTFVTIIQRNQYSSLEVKSKEDGSWIAVDFPPSSFLVMAGDCLVAWSNGRVHSTVHRIRMRPGETRFSTALFSYHSGMVHVPEELVDDEHPLQFKPFDQMGFFRFTFAYYPLSDESKIKAYCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URP9</accession>
    <name>A0A068URP9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">aminocyclopropanecarboxylate oxidase</fullName>
            <ecNumber evidence="8">1.14.17.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031990001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = ethene + L-dehydroascorbate + hydrogen cyanide + CO2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:23640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18153"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.14.17.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.4" evidence="8"/>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URP9"/>
    <dbReference type="FunCoup" id="A0A068URP9">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URP9"/>
    <dbReference type="Gramene" id="CDP10992">
        <property type="protein sequence ID" value="CDP10992"/>
        <property type="gene ID" value="GSCOC_T00031990001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URP9"/>
    <dbReference type="OMA" id="ECYKTER"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009815">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009693">
        <property type="term" value="P:ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000010">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0266">Ethylene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="153"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="313" mass="35359" checksum="446FB2FF892F23CB" modified="2014-10-01" version="1">MAIPVIDFSKLSGEERAKTMAQIANGCEEWGFFQLVNHGISEELLEKVKKVASECFKLEREEGFKNSTNVKLLNELMEKKSSDRLENVDWEDVFLLSDNNENEWPSKTAEFKETMKEYRAELKKLAENLMEIMDENLGLPKGHIRKAFNGGEEANAFFGTKVSHYPPCPNPEKVIGLRAHTDAGGVILLFQDDKVGGLQILKDGEWIDVQPLPNSIVINTGDQIEVLSNGRYKSVWHRVLATQDGNRRSIASFYNPSLNATISPAPELIEKAQGKEVNQEGAYPKFVFGDYMSVYVQQKFLPKEPRFQAVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URV3</accession>
    <name>A0A068URV3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00033358001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A068URV3">
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    <dbReference type="STRING" id="49390.A0A068URV3"/>
    <dbReference type="Gramene" id="CDP11240">
        <property type="protein sequence ID" value="CDP11240"/>
        <property type="gene ID" value="GSCOC_T00033358001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URV3"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URV3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000037">
        <property type="entry name" value="Glutathione S-transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000198">
        <property type="entry name" value="Glutathione S-transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
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        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="208"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="41520" checksum="368AD9F67327BD89" modified="2014-10-01" version="1">MSLSIYKLQTFLNSAVGVGGAKQQRPFCLLQLSFKHTIPMARSALDEMSATGAFVRTPSTFRNLISRDPNSPFPAEAERYHLYISYACPWASRCLAYLMIKGLDKCISFTSVKPKWERTKEADEHMGWVFPASSSEEAGADPDPFNGAKSARELYEIASTNYSGKYTVPVLWDKKLNTIVNNESSEIIRMLNTEFNHLAENPELDLYPSHLQDQINEINGWIYDDINNGVYKCGFAKKQEPYNEAVKKLYEALDKAEEILNKQRYLCGGTVTEADVRLFVTLIRFDEVYAVHFKCNKKLLREYPNLFNYTKDIFQIPGVSSTVNMEHIKKHYYGSHPSINPFGIIPQGPDIDYSSPHDRARFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT63</accession>
    <name>A0A068UT63_COFCA</name>
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        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034141001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739143">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00034141001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT63"/>
    <dbReference type="OMA" id="RLFHQFE"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44137">
        <property type="entry name" value="BNAC03G44070D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44137:SF24">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="726" mass="82891" checksum="C780C8E876304D2A" modified="2014-10-01" version="1">MAGGNPGRNSPPEPEPESEALRLKNQAEQKYVAGNLKSALKYAKRAHRLQSSLEALPEMLTSFKILRTATKPFTSTPPERGGGDGAASIPPAPPDYYKILQIERFAHINTIKKQYKKLALTLHPDKNPFIASEEAFKRVGEAFRVLSDRIRRKEYDMSLRIAMQNEAEAAAGAAGGGVEEVETFWTACSTCRLLHKFESKYLGHNLVCPSCKKSFKAVEVEVEEEEEENASTVQRGEEGENVGLRTSERIKARRLGKMSSVGGVLERSGGKHKGLREKLMVKDLENVGRKRGLEGGGDDGVIEELRSRSEKKEGRTGGVEMEERATTRARTKRVKVDEEETMTLAEMQMLAKKKVSQQKMKLKAKEKEVEEREKEKDKNMGNEELKEKENEMETQNEKSKEKEIEMENEKEEEEIEKDTQKKQQKLNEKESNMGLERVNEREKRDRKMGVSSNEKSMEVVGRRASRSSRDLVIEKRKRPRQNNREIVAVEASDFYNFDEDRVERSFKKGQVWAIYDSEDGMPRRYALIDEVVSLNPFQVRLSWLEFQNNGDEQLIGWEKIGFHISCGRFKVSEKASVKSPKMFSHLPDCERAAKEVYRIYPKKGSVWALYDENALDSGRKQMKNKGCYDIVVFLTSYSEIHGLSMAYLEKVDGYKTIFKRKEFGAHAVRWLVKDEFRLFSHQIPGRKLSGEEAPGLPRDCWELDPACLPPNLLTIGWVNKDVGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUJ3</accession>
    <name>A0A068UUJ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-associated kinase regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035470001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        <property type="gene ID" value="GSCOC_T00035470001"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039619">
        <property type="entry name" value="MAKR2/5"/>
    </dbReference>
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        <property type="entry name" value="MEMBRANE-ASSOCIATED KINASE REGULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33929:SF1">
        <property type="entry name" value="MEMBRANE-ASSOCIATED KINASE REGULATOR 2-RELATED"/>
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    <proteinExistence type="predicted"/>
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            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
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            <end position="212"/>
        </location>
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            <begin position="231"/>
            <end position="264"/>
        </location>
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        </location>
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            <end position="208"/>
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    </feature>
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            <end position="241"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP12091.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45281" checksum="B182F71BF2BBB492" modified="2014-10-01" version="1">MEAFSLLKYWRGGGAVFKSDGPTNLRAADSSSSSSAATTTIVTALSPFSSDSDSDGGDDGPFFDLEFTLPEEDDDSDSEEQMKDHKDLVPNVDEQVENVKNDEEEEEGEEIKFTLSSSSSGDSNDPNVSLSPSDDLFFKGRLVPIDSSSMILSAAEALPKFHPVSSILKSATKFRVQMLNFNKSKSNSRENHKKSEPQEKPENQERKQQTSKLFTVKLKVEEVPLVSLFTRDNSSKGTNSKSIKRSNDVVVENTTDSNGPTDERKFSKDVMQKYLKKVKPLYVRVSKRYGDKLRFSGQLSFPKPGAGPPPTTAEVACEAAGGSNVVKSTQKQGNLQAGLRVVCKHLGKSRSASSAVVTAPAAPVASNRRDDSLLQQQDGIQSAILHCKRSFNASRDLEASILSRSVSDPSHEKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
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                <person name="Giuliano G."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="131" mass="14582" checksum="1B8737050E2ABB39" modified="2014-10-01" version="1">MAVPVEEAIAALSTFSLEDDQPEVQGPGFWVSTERAATTSPVEYSDVAAYRLSLSEDSKAINQLNVLIQEGKEMGSVLYTYRSCVKALPQLPDSMKQSQAELYLETYQVLDLEMSRLREIQRWQASASSKA</sequence>
</entry>
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            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
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        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="255" mass="29332" checksum="5FBA9C10A55D3EC3" modified="2014-10-01" version="1">MPTGMSRLGTNVQHNKSLGSETAETPESKVIQVVKEKWLWDKPPAGFYKVNVIITRMGDRFIVACIIRDENGMLVDPLGHIVEFPYKEENACLVAFQAMQAGVAYFLKRVPGKTKLIVECDNRNAVSMYEEPRPAIPVKFRETYWRIADLSDQLEELKAHWVPQEVNQLAAVYLSQTKNGLEMDQIIHDENWKTIYESNMKGEAVETKTKFVYPGPEWDMKKSIQKMREKYAKLEANAKDPERKAKYSQHYAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWP4</accession>
    <name>A0A068UWP4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739154">
        <property type="protein sequence ID" value="CDP12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWP4"/>
    <dbReference type="STRING" id="49390.A0A068UWP4"/>
    <dbReference type="Gramene" id="CDP12677">
        <property type="protein sequence ID" value="CDP12677"/>
        <property type="gene ID" value="GSCOC_T00037263001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWP4"/>
    <dbReference type="OrthoDB" id="1923451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWP4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052451">
        <property type="entry name" value="Ser/Thr_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008:SF14">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="19391" checksum="C7C58C0236FB5041" modified="2014-10-01" version="1">MNVIIDVASALEYLHRSYSIPVVHCDLKPNNVLLNEDMVACVTNFGVPKILSILHQYGSEGLVSTGSDIYSYGSMLIEVFARLKPIDEMFSDTRLRNWVKSYVPTANCIGGHNVYCENSYSLHRRFSQGQDECYRCSCFSRIARQPRKLFTQNKEIHILEIDFMSILRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXA4</accession>
    <name>A0A068UXA4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00035664001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXA4"/>
    <dbReference type="FunCoup" id="A0A068UXA4">
        <property type="interactions" value="2949"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXA4"/>
    <dbReference type="Gramene" id="CDP12238">
        <property type="protein sequence ID" value="CDP12238"/>
        <property type="gene ID" value="GSCOC_T00035664001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXA4"/>
    <dbReference type="OMA" id="TDWHVFA"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXA4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="11">
        <location>
            <begin position="106"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="425" mass="48398" checksum="66C9862A78C3274A" modified="2014-10-01" version="1">MAPHDLRRPFKRPAISDQQRRRDLSLLRQKQNRLDAQRRARCLASSVLSFQSEPKSPSQEQSHFELELELEIEPDAEEHQGPATTYDVRQASKLRGTEARRWFAKQLMLPEWMIDVPPNLNTDWYVFARPAGKRCFVVSSNGTTVSRLRNGILLHRFPSALPNGARINNVSRSSQSYCILDCIFHEPDQTYYVIDMVCWAGFSLYECTAEFRFFWLNSKLVEVGVCDTPSTFHKYRFATVPVYNCDQEGLQTAYIGPVPYIKDGLLFYNKHAHYETGNTPLALVWKDENCSEYVIDTDSKGQVPNQQQLVLELQDDGRLATSDDPSVIFGWLNEDFIQKTGLHAGNLLRFAVNDGGLSFVDGKLEKADLQYLGQSNRARAFADSYSKVMFQYIVRHSPLKIEHLFASIGPLGDGDIANHDVEMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY36</accession>
    <name>A0A068UY36_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036198001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY36"/>
    <dbReference type="FunCoup" id="A0A068UY36">
        <property type="interactions" value="2139"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UY36"/>
    <dbReference type="Gramene" id="CDP12558">
        <property type="protein sequence ID" value="CDP12558"/>
        <property type="gene ID" value="GSCOC_T00036198001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY36"/>
    <dbReference type="OMA" id="AGMDWIF"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY36"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010215">
        <property type="term" value="P:cellulose microfibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010078">
        <property type="term" value="P:maintenance of root meristem identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009831">
        <property type="term" value="P:plant-type cell wall modification involved in multidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009663">
        <property type="term" value="P:plasmodesma organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001009">
        <property type="term" value="P:regulation of plant-type cell wall cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009826">
        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044224">
        <property type="entry name" value="KOBITO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46701">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE KOBITO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46701:SF7">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE KOBITO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59989" checksum="1305E4807F431E59" modified="2014-10-01" version="1">MAGLYTSLRPQLPSSASSATSLHSFTSKLLLLLTVLPLTLAFFAFVLQWRGGGVDDPISRWSPEESHKFPGMDSSPLATVGAHSSQSSDCSSLLGHANTASFPYYRDWKFNFQADLKPKICITTSTSAGLEQILPWMFYHKVIGVTTFLLFVEGKAASPDVSKVLESIPGVKVIYRTKELEEQQARSRIWNETWLSSFFYKPCNYELFVKQSLNMEMAIVKARDAGMDWIIHLDTDELLHPAGGREYSLRRLLLDVPGNVDMVIFPNYESSVERDDIKEPFTEVSMFKKNYDHLTKDTYFGMYKEATRGNPNYFLTYGNGKSAARIQDHLRPNGAHRWHNYMKTPNEIKLEEAAVLHYTYAKFSDLTSRRDRCGCKPTKEDVKRCFMLEFDRSAFIIASTATEEEMLTWYREHVVWGDRTLNLKLLRKGILTRIYAPMVVIQGLREAGVFSTVITSAQASLSKDKFLASIEKSNSTRAVSSQSLPSRKIGKNHDSQATARRIFDTAAAAYHEAAIPPLSPPVMDNDLMNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYY3</accession>
    <name>A0A068UYY3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00038485001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYY3"/>
    <dbReference type="STRING" id="49390.A0A068UYY3"/>
    <dbReference type="Gramene" id="CDP13517">
        <property type="protein sequence ID" value="CDP13517"/>
        <property type="gene ID" value="GSCOC_T00038485001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYY3"/>
    <dbReference type="OMA" id="GIENSCT"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF8">
        <property type="entry name" value="CYTOCHROME P450 71D11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658368" evidence="6">
        <location>
            <begin position="31"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="368" mass="41632" checksum="A5CA429B095FA6EE" modified="2014-10-01" version="1">MDLSSNSIPLFLFLAFVLALLMQWKRPNAAAQMQKLPPSPWKLPFIGNLHHLVGSLPHHALRKLAQKHGPLMHLQLDRAVSPAIRIVLYGASDIAFAPYGDYWRQMRKICTQELLSARTVQSFSPIRQAEASRLVSSIQALAGGKEPINIAEKLYMYSSPMIRRSAFGKVSRDDQNAFVQIIKDGVGTEGMEIADLFPSYKFLHFFSVVRIKLEKWMQNQDKLLSNILRQHIRDFATKKSSTGGEFGQEDLIDVLLRVRESGGLQCQMTDDNIKAVIVDMFLGGIENSCTTVEWALAEMIRKPDVMAKGQSEIRTAFMGKKIIEEIYVLRGFTTTDIQNLRYLKSVIKETLRLHPPVPLLVPGECREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ74</accession>
    <name>A0A068UZ74_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00038939001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739161">
        <property type="protein sequence ID" value="CDP13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ74"/>
    <dbReference type="Gramene" id="CDP13840">
        <property type="protein sequence ID" value="CDP13840"/>
        <property type="gene ID" value="GSCOC_T00038939001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ74"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="60" mass="7402" checksum="1DC62391CA8E5C7E" modified="2014-10-01" version="1">MLQYLDSWRTWLVDLGTYRCQQLFHIQSWLAFFELKLRGYLQVRNHLQLPFLLFLFPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZL2</accession>
    <name>A0A068UZL2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00038983001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZL2"/>
    <dbReference type="STRING" id="49390.A0A068UZL2"/>
    <dbReference type="Gramene" id="CDP13861">
        <property type="protein sequence ID" value="CDP13861"/>
        <property type="gene ID" value="GSCOC_T00038983001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZL2"/>
    <dbReference type="OMA" id="KMVTMFS"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZL2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12660:FF:000001">
        <property type="entry name" value="Metacaspase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF6">
        <property type="entry name" value="METACASPASE-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06943">
        <property type="entry name" value="zf-LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="360" mass="39502" checksum="CF5F0FDA2ACC1DE8" modified="2014-10-01" version="1">MLMLVDCSNCRTPLQLPQGAKSIRCVICHAVTLIADPRGVPPPPPPQPPAPYYHPPPPPSPYNHAPPGQPPRVHGRKKAVICGISYRNTRQELRGCINDAKCMKFLLINRFKFPSDSILMLTEEETDPYRIPTKHNIRMAMYWLVQGCQPGDSLVFHYSGHGSQQRNYNGDEVDGYDETLCPLDFETQGMIVDDEINATIVRPLPRGAKLHAIIDACHSGTVLDLPFLCRMDRTGRYTWEDHRPRSGAWKGTSGGEVISFSGCDDDQTAADTDALSKVTSTGAMTYSFIQAIERGQGTTYGSILNSMRSTVTSNEDGLGGGIVTSLLTMLLTGGSLSGTRQEPQLTANEPFDAYTKPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZW2</accession>
    <name>A0A068UZW2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00038826001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZW2"/>
    <dbReference type="FunCoup" id="A0A068UZW2">
        <property type="interactions" value="2602"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZW2"/>
    <dbReference type="Gramene" id="CDP13774">
        <property type="protein sequence ID" value="CDP13774"/>
        <property type="gene ID" value="GSCOC_T00038826001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZW2"/>
    <dbReference type="OMA" id="SEAMCID"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZW2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000131">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="146" mass="16659" checksum="02E80ADE99A46BC7" modified="2014-10-01" version="1">MPKNKGKGGKNRKRGKNEADDEKRELVFKEDGQEYAQVLRMLGNGRCEAMCIDQNKRLCHIRGKMHKKVWITTGDIILVGLRDYQDDKADVILKYMPDEARLLKAYGELPDNVRLNEGIAGEMDDDDDGHGDISYLEFGDDDIDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3D1</accession>
    <name>A0A068V3D1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042628001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3D1"/>
    <dbReference type="FunCoup" id="A0A068V3D1">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3D1"/>
    <dbReference type="Gramene" id="CDP15072">
        <property type="protein sequence ID" value="CDP15072"/>
        <property type="gene ID" value="GSCOC_T00042628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3D1"/>
    <dbReference type="OMA" id="RFDLTFC"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3D1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07528">
        <property type="entry name" value="HAD_CbbY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000036">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00035">
        <property type="entry name" value="phosphoglycolate_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="333" mass="35725" checksum="08DF8242EBF65E04" modified="2014-10-01" version="1">MAATTTISHSSLITLYSNSQLNTSSVLKNTFLSSTSLLYSSSSTISINSCNTKICGGVTLKSRNGRGGIRGGRLVCLAASSSSAPSVNLPKALMFDCDGVLVDTEKDGHRISFNDTFAEKELGVTWDVDLYGELLKIGGGKERMTAYFNKVGWPEKAPKSEEERKDFIASLHKRKTELFMALIEKKLLPLRPGVAKLIDQALDNGVKVAVCSTSNEKAVTAIVSFLLGPKRAEQIQIYAGDVVPRKKPDPAIYLLASSTLGVDPSSCVVIEDSAIGLAAAKAAGMKCIVTKSGYTAEEDFLNADAVFDCIGDPPEERFDLLFCGSLLEKQYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3L1</accession>
    <name>A0A068V3L1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00042837001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3L1"/>
    <dbReference type="Gramene" id="CDP15211">
        <property type="protein sequence ID" value="CDP15211"/>
        <property type="gene ID" value="GSCOC_T00042837001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3L1"/>
    <dbReference type="OMA" id="PSHVESW"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3L1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1294"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1420"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="181"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="880"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1449" mass="163580" checksum="47AD1D6C820C155B" modified="2014-10-01" version="1">MPQNSPNSSPKSRWSPIGDTSIEETYSSVCRNSVVSDKTINFTSEYNFETPRTILQTPIYPGSSTPDIRQTIQNASPGTAKSIAFNMYQSLKQHGLRDEIGRAFTRDRSAEEDSRRSEELLGMEYILRDGFVSYLRDVAKITPPIPQQVIRFSDISYAKKVEIPSNKYETFGNKVVGWFTGPFKKIFQSKNSTWINILKGIDGYIMPGSMTLLLGPPGCGKSTLLEILAGRARGDKNSHLQGVVMYNDKYASEVHLSRLVAYVSGQLNNFISRRRIQFCRHIPFLSVRETLEFARDCSQTLRPENFTPQMRKFFAHALVEGQDPFLEYILEILNLKNIEHKLTGEAISDTDRQKLTTVELALGTYAVMLYDQPLSGSDLAATYDLADTIRTVCRIQQSSAIMSLTHLSQEIFDLFDRIILLGDGHVVFQGPRTNNAPIHRILGTISTDYRLRSYRIRKKLHQHEHASHAYSTLQKAAGHIRIQVERYETKEESYQPQWEKSQTPFTQTWLKSTKTLIGRQIKITKRLQILLMLRLFQAMILGLFTGTLFYKLGGQYDQQKMNSVRALGFVSTMSIMLINLVQLALYLLQRPIFYKHRAQKFFRASSYVVAHSIVNIPQTLIEAASYTFSMYFLVGLSFSGNGTALVEYLLLLFLVAYFGSSVFFFLSAVSSIPEIGNALAGLLVSIFLLFSGFVIYPSNIPTYWKWLTYINPIRWANISYCRSQFQYYDDPCSNYKGQFPFCDQFPSNTVGKAYLLYYELLNDNFGPWFPYAVLIGWTAVMTILALCGLKTLEFKGLNQSLPHLKRSTVVSNFRKDKERELSSSGSASDQDLYPTMDTRPTILPPGVKVTDDRGVERWIEDIAIDMERRELGIPVEPVSFMFEDLSFTRFDIEMKKKILVFNRITGYANPKNMLALLGGSQESKSTLLKCLAGRIPSSPYLQGDLRANDVIPAETFFRLIGYVEMVDAHQPYLSVRESLQFSAALRLNREIDTRSRHIHVELVLDQLGLLPYSNQLLGSLRDATGRTFEIAKKMTIAVELAANPSILFLEEPIYGLDSAGISSILAILSELSASRLNIIATLTHPTVRSLSFFDQALILTREGEQAYFGPIGPNCEDLLNYFSPIPSSPRKLTGESPISLVMGYLGQGIKSRGTPSINFADKYRASSLHKQVNEEIAAIKNLRKVRVPIKTAPAYPAPYSRQAGLVLLRTQRFLWRNVQYTYGRLTGCIMIGFLMGSLYYQIKYSDLYGVTSRSLYIYMQVILIGVISANNVIPQIGMDRLVYLREKRAGMYLPIFYPLSWAVGEIPYFFIATLAMVGIGNGLAGIGTRSVPEFLEYWLVLCVFTLCVTYFGMMVIFLAPLLIFAAFLVSILTSLWVSASGVVVTCASDGSCKRLPDGSYVWDRLANSQVLSHTRINTDIPILSAMGVLFASLDFLFFSMLRHNKNPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3S2</accession>
    <name>A0A068V3S2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042746001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3S2"/>
    <dbReference type="Gramene" id="CDP15149">
        <property type="protein sequence ID" value="CDP15149"/>
        <property type="gene ID" value="GSCOC_T00042746001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3S2"/>
    <dbReference type="OMA" id="GHYNRGV"/>
    <dbReference type="PhylomeDB" id="A0A068V3S2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010800">
        <property type="entry name" value="GRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389:SF16">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389">
        <property type="entry name" value="NODULIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07172">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658521" description="Glycine-rich protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8655" checksum="8C59D6114818F1AF" modified="2014-10-01" version="1">MGSKTLLFLFISLAIALMITSEVAARELAETSTSVDNSNAVETDGYGGYRGGGYGGHPGGGYGGYHGGGYGGTWWRRLWWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4D9</accession>
    <name>A0A068V4D9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00042115001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP14698">
        <property type="protein sequence ID" value="CDP14698"/>
        <property type="gene ID" value="GSCOC_T00042115001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4D9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13840" checksum="3FBA6B7661771819" modified="2014-10-01" version="1">MIMCNVASPSRFSLQKQRLGSTTPHIGGLYHHWHLKYKRSIIITKIRSMKANEIKKFKSTAIVSDLSLIKIVISCIGAITTPQILSSNIFHRFHQNNFFLFPVLLKIKDKQKKRPDFCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4F2</accession>
    <name>A0A068V4F2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purple acid phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00043120001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="9"/>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4F2"/>
    <dbReference type="FunCoup" id="A0A068V4F2">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4F2"/>
    <dbReference type="Gramene" id="CDP15399">
        <property type="protein sequence ID" value="CDP15399"/>
        <property type="gene ID" value="GSCOC_T00043120001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4F2"/>
    <dbReference type="OMA" id="TRAHWSW"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4F2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF7">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104041" description="Purple acid phosphatase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="10">
        <location>
            <begin position="145"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="11">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP15399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="439" mass="50113" checksum="71A9A95FB767C39D" modified="2014-10-01" version="1">MEVSTRRLHFFSLITLLSFPHHLHASPEYSRPPPRPIIFTSHTRSESDPQQVHISLVGVDHVRVSWITSHKHTKSTVDYGKSSGTYEASATGDHTSYHYFFYSSGEIHHVVIGPLEPSTTYYYRCGGSGPEFSFRTPPSDLPIDFVIVGDLGQTEWTASTLSHVGARDYDVFLLPGDLSYADTHQQLWDSFGRLVEPYANRRPWMVTEGNHEIETFPIVYPHGFRAYNARWRMPYEQSGSESNLYYSFNVAGAHILMLGSYTDFDADSDQYKWLEADLAKVNRTTTPWIFALLHAPWYNSNEAHQGEGESMRQAMEELLYKARVDAVFAGHVHAYERFTRVFDNTADPCGPVYITVGDGGNREGLALNFEKQKPSISVYREASFGHGRLRVYNQTHAHWSWHRNNDSDSFEADQVWLQNIYASTTSCMEATPQSQRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6G7</accession>
    <name>A0A068V6G7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00017244001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6G7"/>
    <dbReference type="STRING" id="49390.A0A068V6G7"/>
    <dbReference type="Gramene" id="CDP16162">
        <property type="protein sequence ID" value="CDP16162"/>
        <property type="gene ID" value="GSCOC_T00017244001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6G7"/>
    <dbReference type="OMA" id="HQRRTYY"/>
    <dbReference type="OrthoDB" id="1909330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6G7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044837">
        <property type="entry name" value="REM16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391:SF101">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS01G0234100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31391">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS11G0197600-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP16162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="417" mass="47514" checksum="6F23C8DAA76A57F4" modified="2014-10-01" version="1">MGKYVFVKPTRKRITCMQKENTINKKPKRESCPPMKVKIEVDEMQITCYDEMMEKNVESSHADSDKTKSSPQENRKQIMCYSKNVETSSDSSMAGSDKAKSTALLDRANEFVAKLPSDDPNFVKLMLPSQVSGGFWLQWPKDFCQKHMPKKDEYIVLLDENEKEYDIKYLAQKSGLSGGWRGFSIKHQLSKGDVLIFQLVDSNKFKFKVHIFKAKGGSRKLERDNGLLNSEGKVASEIAKDVKETESFNILWNGEVIDSEISEHVRSQYYQLCCSKKSGLHDGLVKCIDKKLAAGIISETVKIADAIRAAEITTTSCNDVRRWDQTLKGFEGMGMNVAFLRAAIKNILDSIQRKQQEKIKRKTNERAQAEKEMRNLETQLVNVKKKIRVLDDEINNVIRAQNEKHEHSFKEAAIAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6J9</accession>
    <name>A0A068V6J9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00018267001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="HG739208">
        <property type="protein sequence ID" value="CDP16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6J9"/>
    <dbReference type="FunCoup" id="A0A068V6J9">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16405">
        <property type="protein sequence ID" value="CDP16405"/>
        <property type="gene ID" value="GSCOC_T00018267001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6J9"/>
    <dbReference type="OMA" id="RVDHFYS"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6J9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000565">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF276">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="9">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="542" mass="58117" checksum="B105E81A8896F662" modified="2014-10-01" version="1">MGGNGKFRRWKISIYKSSSSSSSSSSKSQQKLDPPAEFLCPISGSLMSDPVVVSSGQTFERVAVQVCKDLGVIPNLSDGSTPDFSAVIPNLALKSSIINWCRQSRVEIPSPPDYSSMETTIVQAKTASQQEPSVSETELLRGVENNPQFLFSHAASDLNPRNNYSSSSEESVIANATPFLPFATRPACYSSPSSSAPSSSSSETVYDEALGTPDGIGTGIGMDEMFVTKFKSLDVMEQEEAVILLRKTTRANDEDARVRLCTPKLLQAIKPLLVSRYPIVQTNAVASIVNLSLANVNKVKIVRSGMVPILVDLLKGGFEESQEHAAGGIFSLALQDENKMAIGVLGALEPLLHALRSGTELTRRDSALALYHLSFVSSNRVKLIKLGAVGILLGMLRSGVLVGRVVLVVCNLAVSPEGRSALLDGGAVASLVAILRDGSESDSSESTRENCVAALYSLSHGSLRFRGLAREARASEVLQAVVEHGSERAREKAKRILAVLRGRDGEEESGEIDWEAVMEGGLSRTRHRVPARYSSGLNSTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8Q3</accession>
    <name>A0A068V8Q3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme-binding protein 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005288001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739224">
        <property type="protein sequence ID" value="CDP16932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8Q3"/>
    <dbReference type="STRING" id="49390.A0A068V8Q3"/>
    <dbReference type="Gramene" id="CDP16932">
        <property type="protein sequence ID" value="CDP16932"/>
        <property type="gene ID" value="GSCOC_T00005288001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8Q3"/>
    <dbReference type="OMA" id="VKSGCTD"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8Q3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655640" description="Heme-binding protein 2-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24964" checksum="9E81FE8F3A228E46" modified="2014-10-01" version="1">MEKPKLFLSYIILTVMMVDLCLIAQSREIESPQYTVVHSESDFEVRFYRDSVWMSAPAKETSFRKATKDGFHRLFQYIQGANLNFSRIYMTAPVLTSIVPGAGPLHASAYFVKLYLPLKFQASPPLPLPELDLAPDSWSSHCIAVRQFSGFARDSNIVKEAEKLAISLSRSQWANSTSHSEYAYSIAQYNSPFRIIGRKNEVWVDVAGSEANGCKSSLLASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9L4</accession>
    <name>A0A068V9L4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00000658001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739232">
        <property type="protein sequence ID" value="CDP17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9L4"/>
    <dbReference type="FunCoup" id="A0A068V9L4">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP17192">
        <property type="protein sequence ID" value="CDP17192"/>
        <property type="gene ID" value="GSCOC_T00000658001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9L4"/>
    <dbReference type="OMA" id="AYSHEDS"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9L4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF2">
        <property type="entry name" value="F18C1.18 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HIG1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="104" mass="11542" checksum="CD35C9AE37D83887" modified="2014-10-01" version="1">MAVADSKTATKSSFESIREWVVEHKLRTVGCLWLSGIGGSIAYNWSQPAMKTSVKIIHARLHAQALTLAALAGAAVVEYYDHKTGKTQDRYPKYLPLDTYSQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB15</accession>
    <name>A0A068VB15_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00003882001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB15"/>
    <dbReference type="FunCoup" id="A0A068VB15">
        <property type="interactions" value="1516"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB15"/>
    <dbReference type="Gramene" id="CDP17767">
        <property type="protein sequence ID" value="CDP17767"/>
        <property type="gene ID" value="GSCOC_T00003882001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB15"/>
    <dbReference type="OMA" id="VYNAHRF"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB15"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009407">
        <property type="term" value="P:toxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000100">
        <property type="entry name" value="Glutathione S-transferase Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000017">
        <property type="entry name" value="Maleylacetoacetate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="248" mass="28403" checksum="CF888EE016C7610C" modified="2014-10-01" version="1">MGYRSCNKTITPIHFNFFFIVIIAAFMAGEESKKLKLYSYWRSSCSCRVRIGLNLKGLEYEYVPVNLLKGEQRTPEFLKLNPVGLVPVLVDGDVVLADSFAILMYLEEKFPQHPLLPKDLHRRGINYQAVNIVCSSIQPYQNIPILKFMKEKLGPDADVAWARDHIQRGFAALEKLLKDYSGKYATGDEVFLADLFLAPQIDGAIRRFKVDMDEFPLLARIFKAYLELPAFRDAMPERQPDAPAEHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBE7</accession>
    <name>A0A068VBE7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012859001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739284">
        <property type="protein sequence ID" value="CDP18051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBE7"/>
    <dbReference type="Gramene" id="CDP18051">
        <property type="protein sequence ID" value="CDP18051"/>
        <property type="gene ID" value="GSCOC_T00012859001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBE7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8380" checksum="B594F6CD11CF36D1" modified="2014-10-01" version="1">MAAAPSLILRRFVLFSIAAKDEELRRVLGSRPHVIGKGHHRLPLHFLLECQGTEVICIESLKMKAVVINDVNLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC13</accession>
    <name>A0A068VC13_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012974001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739315">
        <property type="protein sequence ID" value="CDP18390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC13"/>
    <dbReference type="Gramene" id="CDP18390">
        <property type="protein sequence ID" value="CDP18390"/>
        <property type="gene ID" value="GSCOC_T00012974001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC13"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="382" mass="42811" checksum="4182EDF61401951C" modified="2014-10-01" version="1">MNTHRQYGFGKVEAQFDDNVNTCHDVVDLRDELFVRLANSGFVDVAAVLAAISNIPLTFQSRVVNVGELLCGKSSTAVHHDCSQSEDILLNGNRRSKLTVGVKRARAGKSLVQQQSFNQFENENELGVQKWVNNNLDTEIPFKETAEDVLTFIPEGGEEEEDLTFTEKSSQKNGEDLRKHELRLLGDLPVHVQEILGEDASLPNAEATVYAPVPTDDGVNLSALKTHQMDLQVGNNQEIEVSVKSPLTVESSPTEIIGVVDKIDAVELIEEKKNNLQSVMDFVMLEWKDFEGHVKMIQNSISGFFGELESGETDLKPVQESASKNSEELISRRKWVEKRFKKLDEKEKLILELLQKVELAQNKFATIRNFVGEKLENIAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC93</accession>
    <name>A0A068VC93_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00007067001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739302">
        <property type="protein sequence ID" value="CDP18169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC93"/>
    <dbReference type="FunCoup" id="A0A068VC93">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18169">
        <property type="protein sequence ID" value="CDP18169"/>
        <property type="gene ID" value="GSCOC_T00007067001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC93"/>
    <dbReference type="OMA" id="ACSHLEM"/>
    <dbReference type="OrthoDB" id="749902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC93"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001359">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g57430, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000361">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002471">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000733">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF514">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY, DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="5">
        <location>
            <begin position="813"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP18169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="905" mass="100478" checksum="2612F5DC02307712" modified="2014-10-01" version="1">MSFPCTSTQALSQPPYPVSSLQTQIPKPPSQIKTYPQPPLSTTTTKAPFPPTITENPPKPTSHARSLTSWSKEFRSLTQAKRFEEAVSTYIQMTTVGITPDNFIFPAVLKAATGLHDLNFGKQVHGSVVKLGYDYSSVTVANTLLHLYGSCGDVSEVFKVFDGMPERDQVSWNTMINALCKFEEWEMALEALRLMGNEGTEPSSFTLVSAALACSNLGGSDGLKLGKQVHGYSLRVDDCKTFTKNALMTMYAKLGSVGDSKAVFEVYANRDVVAWNTIISACQQNGQFYEALEHFRIMIIEGFMPDGMTLSSILPACSNLELLDIGKEIHAFVLRNEDLVENSFVASALVDMYCNCKQVGSGRRVFDGTPERRLGLWNAMLAGYARNGFYENALMLFMDMMEIPGLLPNPTTIASVLPSCVHCEAFSNKEVIHGYIIKLGFARDRYVQNALMDLYSRIGKITVSEYIFSIMDSRDIVSWNTMITGCVVCGYHENALRLMHQMQEAEISMEWKDNYEGNLGTPIKPNSITLMTVLPGCAALSTLSKGKEIHAYSIRNALASDVAVGSALVDMYAKCGCLDLARRFFDGMPTRNLISWNVIIMAYGMHGKGNEALELFNAMVVDGSRNGELRPNEVTFIAIFAACSHSGLVDEGRQLFHKMKEDHGIEPTADHYACVIDLLGRAGQLEEALQLINSMPIDYDKVGAWSSMLGACRVHRNVELAEISANNLIQLEPDVASHYVLLSNIYSSAGLWEKANNVRKNMKEKGVRKEPGSSWIEFGDEVHKFLAGDISHPQSEQLYSFIDELSDKMKEEGYEPDTSCVLHNVDEEQKENLLCGHSERLAMAFGLLNTPPGTTIRVAKNLRVCNDCHAACKFISKIVEREIIVRDVRRFHHFKDGTCSCGDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFU4</accession>
    <name>A0A068VFU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00004225001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739339">
        <property type="protein sequence ID" value="CDP18563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFU4"/>
    <dbReference type="Gramene" id="CDP18563">
        <property type="protein sequence ID" value="CDP18563"/>
        <property type="gene ID" value="GSCOC_T00004225001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFU4"/>
    <dbReference type="PhylomeDB" id="A0A068VFU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="99" mass="11162" checksum="C17C301571FE9F38" modified="2014-10-01" version="1">MHHKNYLPFLKSRPLLFTAFKRLKIHWQTEPFITGSISNSGEDSLSEPISTALPHSGSDISSPFLQQHLQQGRKLLKYFQSDPGPLSLAKLIPSPHLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGR9</accession>
    <name>A0A068VGR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00008839001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00008839001"/>
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    <dbReference type="OMA" id="LWIVMQV"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="28"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="56"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <location>
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    <feature type="domain" description="EamA" evidence="7">
        <location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP19916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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    </evidence>
    <sequence length="371" mass="41152" checksum="021E9226572357E6" modified="2014-10-01" version="1">MEGYKLYLAAVSVQVFHSIMHIVSKAAIDDGFKTYILVFYRQAIATVFLAPITIFLEWKSAPPLTLMTFVKMCILSLLGFTLTWNLNNMALRYTSAPLAAAINNTIPVITFFLAVLFRMENFNLKTIPGISKFAGIALCLGGSATIAFYHGAPYLKLLVHHHLLKIHSLENPGHAPSSTTWVKGVLLMFLAYILWSSWLVLQGYLSKSYPSTLISINLQNFFGGIFSFIIAIYLERDFDEWKLGWNVRLLSAAYCGIMVNGVGFNLIAWVLRKKGPLFQAIWVPLVLLFTTCFSAVFLGEIISLGSVVGAVLLVMGLHCVLWGKIKEQSKETENCSSTVHLAQISQTAPKDEIQVGSTPKHSLPQNACSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A068VGT8_COFCA</name>
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        <submittedName>
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        <name type="scientific">Coffea canephora</name>
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Priyono X."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
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        <location>
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        </location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP19769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="324" mass="36055" checksum="F8BBD5359DF133BB" modified="2014-10-01" version="1">MEDSEQRKGKVMSLSSLFPPEETQKASERVQDTIAERRNQLDQLKSFVSDNTNLINLVQTLPNELQHQIMVPFGKVAFFPGRLIHTNEFMVLLGDGYYAERTSKQTVEILKRRGKILESQFESLKADIQDLKTEASFFNATANEAAGDLVEIVEDYVEENPMAEVSKAGSMRSESKADFPSSSEAETTRIGYQDDEYAHIFSRIDELEKEEEDAEKDDDDLDHTTDKRDYETGVYGSKVTSVHQDGSSHGGRQASSKPTEKALELPEIKDVIQGPAVTKKVGFAQTTETSSSSSGSKACFLRVIVFHGSAMLNGDIIQFLTSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHC4</accession>
    <name>A0A068VHC4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_913</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">GSCOC_T00000735001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739997">
        <property type="protein sequence ID" value="CDP20111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHC4"/>
    <dbReference type="FunCoup" id="A0A068VHC4">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VHC4"/>
    <dbReference type="Gramene" id="CDP20111">
        <property type="protein sequence ID" value="CDP20111"/>
        <property type="gene ID" value="GSCOC_T00000735001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHC4"/>
    <dbReference type="OMA" id="CLSIEPI"/>
    <dbReference type="OrthoDB" id="201720at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904143">
        <property type="term" value="P:positive regulation of carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15852">
        <property type="entry name" value="PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15852:SF8">
        <property type="entry name" value="PROTEIN ORANGE-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP20111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="316" mass="34519" checksum="9B32F7ACD37F1936" modified="2014-10-01" version="1">MGSSSCLYSLVPSLHPSHVNFSKNLSFLSSSRVARPQGGALLNQSSTPQRIVCSSTDDPNSMPSGENIPSSFCIIEGPETVEDFVQMQLQEIQENIRSRRNKIFLLMEEVRRLRVQQHIKSIKVSDVTGEQENEMPDIPSSIPFLPHVTPKTLKQLYLTSFSFVSGIIVFGGLIAPTLELKLGLGGTSYEDFIHTLHLPMQLSQVDPIVASFSGGAVGVISALMLIEVNNVEQQEKKRCKYCHGSGYLACARCSASGTCLKFEPISTCSDSIRQLHGPTTQRCQNCSGSGKVMCPTCLCTGMAMASEHDPRIDPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHW2</accession>
    <name>A0A068VHW2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00003341001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739470">
        <property type="protein sequence ID" value="CDP19243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHW2"/>
    <dbReference type="STRING" id="49390.A0A068VHW2"/>
    <dbReference type="Gramene" id="CDP19243">
        <property type="protein sequence ID" value="CDP19243"/>
        <property type="gene ID" value="GSCOC_T00003341001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHW2"/>
    <dbReference type="OMA" id="FAIKAHI"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHW2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF40">
        <property type="entry name" value="PHENYLCOUMARAN BENZYLIC ETHER REDUCTASE-LIKE PROTEIN FI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP19243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="287" mass="31326" checksum="B75EB31975BA1BD0" modified="2014-10-01" version="1">MDVKSKILIIGGTGNIGKYLVEASAKAGHPTFALVRESTISDPKRAAIIESFKSLGVIFLHGDLHNHQQLVNAIKQVDIVISAVGGDLVAHQVKIIEAIKEAGNIKRFLPSEFGVDVDRAHAVEPAASLNRTKVEIRRAIEAEGIPYTYLVSNGFAGYLNYILNNFGDSFSASPPRDKIVILGDGNPKVVFTKEEDIAAYTIKAADDPRTLNKSVYITPPANTLSYNEIVSWCDSAESIRRGDVSADFSAKIANFEIKASFGMEATELYPDVKYTTLDEYLIQFVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHZ5</accession>
    <name>A0A068VHZ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00009860001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin-like family. Class-I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG740085">
        <property type="protein sequence ID" value="CDP20212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHZ5"/>
    <dbReference type="STRING" id="49390.A0A068VHZ5"/>
    <dbReference type="Gramene" id="CDP20212">
        <property type="protein sequence ID" value="CDP20212"/>
        <property type="gene ID" value="GSCOC_T00009860001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHZ5"/>
    <dbReference type="OMA" id="MQEDSHQ"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHZ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027643">
        <property type="entry name" value="Formin-like_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213:SF391">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213">
        <property type="entry name" value="FORMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="478"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="892"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="947" mass="103409" checksum="364519CFD08D3C16" modified="2014-10-01" version="1">MRDGKFWDTQSGCIFCVVISCAILQNKILVIILIIVVVQFIGLFLTGTDFCLTQSSMLPSNVTVSQAEDVWIQCRRELKECLQFLESLELYLSQIPEPYENPTLPVDLLAKRIVQQTIPNLTFQDKQFLFECLRKKPLQNHESGKEFGSNTLFNKCPELFSSWSSAPRSAVASPHHAPAPSPVPASSPSPTLHSPSPVLQPPSPEPSPQQNVIHSTLPSSIVVASPHHAPAPSPVPASSPSPTLHPPSPVLQPPPPESSPPQNVIHSPPPSSIVGPLPRPQTGAPTPSGNGLNRNYVIAAIAASAVTGLALIVLFLICCINKRKEQVAPGNGQKNEKRDEKPLLNFCSSDLSAGSTQKSQNIVAFNNQNLKMSSTVSNIPFAVNVVDSSTETQSTKLTNDASENVNSLLPLPPGRPALPRPGPPPPPPPKPPAPAPPPPPKVARPPPNPPKPSNLGRPSPPGANNPRSSSGGNTSELSGESDAPKAKLKPFFWEKVPANPDHSMVWHDIKAGSFQVNEEMMESLFGYVPAEKGKFEHKRNSSSESSVPYVQIIDPKKSQNLAILLKALNVTTEEVIDALKEGNELPIELVQALLKMAPTTDEELKLRLFSGDVSQLGPAERFLKVLVEIPFAFKRMESLLFMSSFQEESSSITESFATLEVACKELRNSRLFLKLLEAVLKLGNRMNDGTYRGGATAFKLDTLLKLSDVKGTDGKTTLLHFVVQEIIRSEGLRAARRLRESHSMSSVKTEDLVEESSEETADYYRSLGLQVVSGLSNDLENVRKAALIDGDDLAGAVSSLGQSFVKLKDFINNEMTNVEEDSEFRTTLTNFVEHAEADITKLLEEEKRIMALVKSTGDYFHGNAGKNEGLRLFLIVRDFLVMVDKACRDVRSSTKLPAKTPRKEALAPSPSEESNRESLPDFRQRLFPAIKERHMDDSSSDEDDKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLQ8</accession>
    <name>A0A068VLQ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_5380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00001110001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG744464">
        <property type="protein sequence ID" value="CDP21636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLQ8"/>
    <dbReference type="Gramene" id="CDP21636">
        <property type="protein sequence ID" value="CDP21636"/>
        <property type="gene ID" value="GSCOC_T00001110001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLQ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="155" mass="17050" checksum="54C7AC3FF5397229" modified="2014-10-01" version="1">MHSLSPSFLDNVALFLPLVHERVEIAGPLLTKQGVSSLVLSRSLGYSGPDVWFSSSSPPFRARSIGPLLLGFSWFQLSRSAAIRSVLLLLLHRKFSSSSFQARCGLCCEFSFVIFNLGTDVFCSFFHCFPFRVAPVLLSGEVRSCQPFGSSPPRS</sequence>
</entry>
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    <accession>A0A068VM65</accession>
    <name>A0A068VM65_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_1718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00007652001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740802">
        <property type="protein sequence ID" value="CDP20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VM65"/>
    <dbReference type="FunCoup" id="A0A068VM65">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VM65"/>
    <dbReference type="Gramene" id="CDP20768">
        <property type="protein sequence ID" value="CDP20768"/>
        <property type="gene ID" value="GSCOC_T00007652001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VM65"/>
    <dbReference type="OMA" id="FHQTAND"/>
    <dbReference type="OrthoDB" id="1865546at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VM65"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040338">
        <property type="entry name" value="At1g67623-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057136">
        <property type="entry name" value="At2g35280_TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33784:SF10">
        <property type="entry name" value="F-BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33784">
        <property type="entry name" value="OS05G0482100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23310">
        <property type="entry name" value="TPR_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="25663" checksum="56CB43D069FF8827" modified="2014-10-01" version="1">MANEQKGSSGTSILSLPTEVLSEVLARVASSSSTDLFRAKLCCKLFYEVSDANNIYQRVSLDKFEIVLWQKNHKVSRFLKNCRESKNPEALYRKGVVDFFTDKHEDSALECVEEAANSGHADAAYALGIIYIFVGRDELKCKGLRLLKKSRILKGRVKLCSDNLLALLRMIWVKNLVFLNPTSICFAMTHERKTSSWPMDADEVEESTCEDCACDEEIGTICAALPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMD3</accession>
    <name>A0A068VMD3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013757001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="HG746383">
        <property type="protein sequence ID" value="CDP21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMD3"/>
    <dbReference type="STRING" id="49390.A0A068VMD3"/>
    <dbReference type="Gramene" id="CDP21866">
        <property type="protein sequence ID" value="CDP21866"/>
        <property type="gene ID" value="GSCOC_T00013757001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMD3"/>
    <dbReference type="OMA" id="AAWFLGY"/>
    <dbReference type="PhylomeDB" id="A0A068VMD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF773">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="191" mass="21632" checksum="98BD4CC1DB7F928F" modified="2014-10-01" version="1" fragment="single">PPPYLNFTLFSTGRTGEKVILLDFLTTIFATKVRIALAEKEVKYKSKEEDLMNLKKSPLLLKMNPINKKIPVLIHNGRPFCESLIIVEYVDELDGFARKIWSTKGEEQQAAKIGFINCQKTLEEGALGDKPYFGGDNFGSLDVALLGNYNWFDTYEKFGKFSIEADCRCMERDSVSKSLADPIKVYESVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMR9</accession>
    <name>A0A068VMR9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_9755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008852001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748839">
        <property type="protein sequence ID" value="CDP22065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMR9"/>
    <dbReference type="STRING" id="49390.A0A068VMR9"/>
    <dbReference type="Gramene" id="CDP22065">
        <property type="protein sequence ID" value="CDP22065"/>
        <property type="gene ID" value="GSCOC_T00008852001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMR9"/>
    <dbReference type="OMA" id="FPAMEDI"/>
    <dbReference type="OrthoDB" id="1865198at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMR9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47211">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47211:SF3">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASR3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="284" mass="32107" checksum="92A426E2D66C8335" modified="2014-10-01" version="1">MAPGPNDRLEKATSSASVLDEEHQAVERTNSENKSTRHPRWTKQETLILVEGKNIAESQGRRGRRSSSLFVTGQHEPKWDSVSSYCRLHGVNRGPVQCRKRWSNLVSDFKKIRTWESQVKEEGESFWVMRNDLRREKKLPGHFDREVYAVLNGNSYQAVMGMSVDGREADGTCVADTEDEDEEDVNRGIETGVVFDSGTHARPETLISHLEKCAQGKIFRGPNAQVARESPRSNSPAPMPLSGLIHAQVSFHPRLQQATNLVDCSTLPPTSFYLLFYTFKRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKL5</accession>
    <name>A0A068TKL5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00013985001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKL5"/>
    <dbReference type="FunCoup" id="A0A068TKL5">
        <property type="interactions" value="2304"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TKL5"/>
    <dbReference type="Gramene" id="CDO96835">
        <property type="protein sequence ID" value="CDO96835"/>
        <property type="gene ID" value="GSCOC_T00013985001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKL5"/>
    <dbReference type="OMA" id="FFESHCT"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKL5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF42">
        <property type="entry name" value="SHAGGY-RELATED PROTEIN KINASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO96835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="43149" checksum="2F2B484CB71E56AA" modified="2014-10-01" version="1">MANDKEMSAPIMDGHDTVTGHIISTTIGGKNGEPKQTVSYMAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDRRYKNRELQLMRTMDHPNVVSLKHCFFSTTSKDELFLNLVMEYVPESMYRVLKHYSNINQTMPLIYVKLYTYQIFRGLAYLHNVAGVCHRDLKPQNVLVDPLSHQVKICDFGSAKVLVKGEANISYICSRFYRAPELIFGATEYTSSIDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTPTREEIRCMNPNYTDFRFPQIKAHPWHKVFHKRMPPEAIDLASRLLQYSPSLRCTALEACAHSFFDELRDPNTRLPNGRHLPQLFNFKQELSGAHPDLINRLVPDHIKRQMGIQLMHPTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM01</accession>
    <name>A0A068TM01_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00014682001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM01"/>
    <dbReference type="Gramene" id="CDO97360">
        <property type="protein sequence ID" value="CDO97360"/>
        <property type="gene ID" value="GSCOC_T00014682001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM01"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO97360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="109" mass="12217" checksum="2ED8DC629781CB69" modified="2014-10-01" version="1">MTLLEGNGCTISRTSNRQGHFLMKLSPMALSLFFLPLSPTTTTATMSEFYIVGQNPTCRHLLQLSFSSLFAHLYHSRLNLPCLSLPFYSTIPFCVEDVCIEGLKRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN61</accession>
    <name>A0A068TN61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00013918001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN61"/>
    <dbReference type="STRING" id="49390.A0A068TN61"/>
    <dbReference type="Gramene" id="CDO96788">
        <property type="protein sequence ID" value="CDO96788"/>
        <property type="gene ID" value="GSCOC_T00013918001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN61"/>
    <dbReference type="OMA" id="SEYHIDC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000004">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF70">
        <property type="entry name" value="ENDORIBONUCLEASE DICER HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="322"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="500"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO96788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="726" mass="82079" checksum="071C02EEF95C72FE" modified="2014-10-01" version="1">MQYVPSELVGCPGNESETLYHCYQIALQPDFSCNTMPHDILLATRARLEFDDETLNFELDVPRGSLKIRMKYVRRIKLASEEVVLCQKFQVTLLRLLLDHNQNKLKEALSGLNRNSQRDVFDYLLIPSTSPHENPSIDWKCVSSVLFPQGNMSDKHMHGCSNRVQVHTIDGLICRCTLQNSLVVTPHDGFMYCTTGILDDPNSRKRRGSITYKPNFAKRHGITLRFEGEPFLCGQRLFKVQNCLLGCRNQETKGSRKASVELPPELCKVIMSPISIGSVSSFAYAPSIIQRIESFLTAGNLKRMLMDDCKLNDMIPTIKVLEAITTKNCRENFHLTSLATIGDSFLKYATSQQLFKTHQNHNNGLLTEERTKIVSNLALCKLGCDKKISGFIRNECFDPKTWIIPGDNSQTYTLRKEVLSTRIIVYAREKRTIKNKTVADVIEALIGVFICTTSERAALAFMKWMGFEVDFVYVQYKRPVAANPEKLVDLRFFKSLLNQYSFRDASLLVEALTHGSYVRPESPTSYEHLEFLGDAVLDYLITKHFHNEHPNLSSGLLTDLRSASVNNDCCARTAIRAGLHKHILHDSQDLQRRILAIAENFEQSSRDSTFGWESEPVIKILADIIKSLAGAIYVDSGYDKGVVFQSIKPLLEPLPTPETLKLQPVRELEEFCAKQHFDMNKSVTYENGEVSANANGVPCARRLTAANKKTARKTASMDILSKLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN96</accession>
    <name>A0A068TN96_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014779001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN96"/>
    <dbReference type="STRING" id="49390.A0A068TN96"/>
    <dbReference type="Gramene" id="CDO97434">
        <property type="protein sequence ID" value="CDO97434"/>
        <property type="gene ID" value="GSCOC_T00014779001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN96"/>
    <dbReference type="OMA" id="WVYCRRI"/>
    <dbReference type="OrthoDB" id="1893318at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN96"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037472">
        <property type="entry name" value="MBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37701:SF18">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37701">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="780" mass="86253" checksum="2E8CE083EA9B4FD9" modified="2014-10-01" version="1">MATAVTTPPPPSSSSSSCGPKLESLANIDITKLSQSELYTLSKCSNSAFDLHRSDDVVVPNIDRSLFNESSGSRRQTYSRLRQSHHHHHHLHPRTRLPGLLPGPKHSPSADPENHAILHYLKHYLNHNSATNCPPPPPPPPLPPRPPPPPPQPVGLGLQEKMAIAVNVVEKKRKRGGKVRWNPGLLENGVGMELERVNKNGLEVDFAALESNGDEFYSAELGRRTMGLETEEGVLEFLRGLEGQWCSRRKKRKYVDAGDFGDALPIGWKLLLGLRRRDGRVWVYCRRIISPTGEQFLSCKEASSFLRSYFEAKSSNQPVDQGTSIVEQAGAVASRRNAGSITNAYQTSHEIVPYLTASGGHDNDVGLMDIDNLPEVQVQDLFECYKCNLTFDEKNLYLQHLMSFHQRTTRRYKFGDAVADGVIIKDGKFECQFCHKVFLERRSYNGHVGVHVRNHVKGSELPTPDSVQKSVDSPSWEGLCQRTSKNALIEIAHNFTSAASSAGPSSAAVEISHPSVMNLNETLAGNTHVGATLVSEPSELEGLNAGRTLNLDLNQHKSDSFMDDGRMSMCNNRQAIEINLKEVLTKDAEQSDAEELKEYGNKIVEIGFGPRSSKQSDDVANSEGPMGEETVHHRGISSSSTPLVQAYDYFSSVPDKGDDEFFLESQKLGNLPSFEELELDDMGPFKYDFADGQESSLPEVSMNLASDTGKGEELNASVGFDSQADQLDMTGTHQFTTVCVWCRSEFKIEAFDSELQSDSIGYMCTTCKDKISGHFSRICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP87</accession>
    <name>A0A068TP87_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00021768001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP87"/>
    <dbReference type="FunCoup" id="A0A068TP87">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TP87"/>
    <dbReference type="Gramene" id="CDO97847">
        <property type="protein sequence ID" value="CDO97847"/>
        <property type="gene ID" value="GSCOC_T00021768001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP87"/>
    <dbReference type="OMA" id="PHDAQVM"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO97847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20098" checksum="F13F1345387FFA3D" modified="2014-10-01" version="1">MGEGAGEEDMPRDAKIVKSLLKSMGVEDYEPRVIHQFLELWYRYAVDVLTDAQIYSDHADKSVIDSDDVKLAIQSKVNFSFSQPPPREVLLELARNRNKIPLPKSITRPGIPLPPEQDTLINPNYQFAITKKQSKQAIEEAEDDEEAADPNPNPSQEQRIDASQGTPQGVSFPIGPKRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPM7</accession>
    <name>A0A068TPM7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021959001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPM7"/>
    <dbReference type="FunCoup" id="A0A068TPM7">
        <property type="interactions" value="1617"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPM7"/>
    <dbReference type="Gramene" id="CDO97997">
        <property type="protein sequence ID" value="CDO97997"/>
        <property type="gene ID" value="GSCOC_T00021959001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPM7"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPM7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47565">
        <property type="entry name" value="CYTOCHROME C OXIDASE 19-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47565:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE 19-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="171" mass="19285" checksum="ED8BE59F88A830EE" modified="2014-10-01" version="1">MKQANYFSQTFGPLHWWVGPRTRRDKYSTANHSAHVKRMRRRSSSLLSCKTGGNGVSFSFVAGITFPRTLIPMSAGGAFGGNRGVRPVPPEKGVFPLDHMHLCDQEKKEYISCLKSSGHKSEKCRHLSKMYLQCRMEKNLMAKQDMSELGFRKESDVEALRDGSRNGSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRD6</accession>
    <name>A0A068TRD6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00025826001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRD6"/>
    <dbReference type="STRING" id="49390.A0A068TRD6"/>
    <dbReference type="Gramene" id="CDO98875">
        <property type="protein sequence ID" value="CDO98875"/>
        <property type="gene ID" value="GSCOC_T00025826001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRD6"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF8">
        <property type="entry name" value="HEAT SHOCK FACTOR-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="119" mass="13425" checksum="0B81063B32B7391B" modified="2014-10-01" version="1">MRRGEFCHFASSERLPNLHICELANQIQNHTHIILFFSSFCKGESQHTHTLTLSPSFGPTATENAEKMDGHDGDASKQSTADMTAFVQNLLQQMQSRFQAMSESIITKNILPFYPCPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTI6</accession>
    <name>A0A068TTI6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00026501001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTI6"/>
    <dbReference type="FunCoup" id="A0A068TTI6">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTI6"/>
    <dbReference type="Gramene" id="CDO99362">
        <property type="protein sequence ID" value="CDO99362"/>
        <property type="gene ID" value="GSCOC_T00026501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTI6"/>
    <dbReference type="OMA" id="FNAGSWL"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTI6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000006">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF121">
        <property type="entry name" value="AMMONIUM TRANSPORTER 1 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="51"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="500" mass="53476" checksum="78DDCC3ACB9A5FD9" modified="2014-10-01" version="1">MASLSCSADQLAPFFGPNTTNATAAAEYICNQFTAVSDRFTDTGYAIDTTYLLFSAYLVFSMQLGFAMLCAGSVRAKNTMNIMLTNVLDAAAGGLFYYLFGFAFAFGGPSNGFIGKHFFGLKQIPSSSFDYSNFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSSFLTGFVYPVVSHWFWSADGWASASNTGNLLFGSGVIDFAGSGVVHMVGGIAGLYGALVEGPRIGRFDRTGRSVALRGHSASLVVLGTFLLWFGWYGFNPGSFNKIFVTYNVGNQPYYGQWSAVGRTAVTTTLAGCTAALTTLFGKRILSGHWNVTDVCNGLLGGFAAITSGCSVVEPWAAIICGFVAALVLIGCNMLAEKVKFDDPLEAAQLHGGCGAWGVIFTALFAAEKYVNEVYPIPGKSTRPYGLFMGGGGRLLAAHVIQVLVILGWVSATMGPLFFILHKLKLLRISAEDETAGMDMTRHGGFAYVYHDEEDSNKNSIPMRKIEPAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU41</accession>
    <name>A0A068TU41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00029420001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU41"/>
    <dbReference type="STRING" id="49390.A0A068TU41"/>
    <dbReference type="Gramene" id="CDO99741">
        <property type="protein sequence ID" value="CDO99741"/>
        <property type="gene ID" value="GSCOC_T00029420001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU41"/>
    <dbReference type="OMA" id="AHIAYDH"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19907">
        <property type="entry name" value="DSRM_AtDRB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000036">
        <property type="entry name" value="Double-stranded RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044450">
        <property type="entry name" value="AtDRB-like_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031:SF26">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO99741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="14055" checksum="96C6EEDB978AE8D5" modified="2014-10-01" version="1">MYKNQLQELAQRSCFNLPSYTCIREGPDHAPRFKATVNFNGETFESPHYCSTLRQAEHSAAEMALNALAGRGPSNSLAARILPATPTFCHEVLPFPIQNKCKQLSAVLCLAISVLGKLLFSYAPLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU82</accession>
    <name>A0A068TU82_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029138001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU82"/>
    <dbReference type="FunCoup" id="A0A068TU82">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU82"/>
    <dbReference type="Gramene" id="CDO99524">
        <property type="protein sequence ID" value="CDO99524"/>
        <property type="gene ID" value="GSCOC_T00029138001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU82"/>
    <dbReference type="OMA" id="KCQFLCH"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU82"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000225">
        <property type="entry name" value="Protein SMG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="201"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="112418" checksum="8E06D68E8F5B7745" modified="2014-10-01" version="1">MEHEATAMHKDQWQKQDNFLEVLNIEKQLLALIHSKGLLHKDVQELYRKVRTAYQSIILNDYDVVDLQEVEYFLWKLHYKHIVEFRKSMRQHWMSGESTKGETSPVDIDSQGNINRYVDGFKTFLSEATDFYSNLTKAFREVCGLPGEVFLYNKGDSSFSTEQMKLSKCHFACHRFLICLGDLARYGELCKKQDASKWSVAFTYYLEASRIWPASGNPHNQLALLATYVGDAFLALYHCTRSLAVKEPFPDAWNNLMLLFEENGSSHLSSLSSETHIDLLKPFEKVSLQAAPQSLTGSSNKSNLETNNIFSTAKTELWPLFVRLISFFLGRSSLEEFESTLSSSVEHLESLVLLDDEQLKAALESYKLMDSSRKGPYRALQLVSIFIFILHNLTESPQNEKLNENDKQQKSGLTQLALIATYICIARLLERCLKCNQLEKCLLLPAVLVFVEWLVGALDEVEKYAADDKVMSAMSYFFSALADLLNRFNIGEGETACDKSALWEDHELRGFEPMANAHASLDFTSTHWEWMATLDSKRSHRIFHAGMRIVNRSANNKQWIFCDKKGLKFFTFGSMELLGQGKTVGVSNLNVKVKEVDEQISRNVEVHEQDSLGETQPQRCQKSVPVSTEEEEVILFNPITRHNSAPLYKYITENDHMYREGLKEPALSADECLRRATSMFIGKNQPRSDRASFSPDATNVKYNKPLKESATYPAGPPSLSAWVFDRDKLDYEPEKGIKNFTKHELTPIQETAFESLTGLLHDRTRDSVAGPDHVSAAAQTLSPPTYVAPVPSAPLLPDDATWSRGSLPSFPEYKSALGSRETDGILGAPPVSGYSNGSAPHGPLDFSPVLPGLVHGYPPLLGMSSSEWLYHYRNNHKLDQTSTLFWPVHMNGPGPLSSFQTNDLSRFDLFSQWGNPLASTPTFYMESPQLHPGSSLVYSAGDPQKDSLLSYQRASPFVCGAVTDPRPEQQPLLHYLKEKEWQLHSPQFRGSAFMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUK0</accession>
    <name>A0A068TUK0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst subunit Exo70 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00029653001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUK0"/>
    <dbReference type="FunCoup" id="A0A068TUK0">
        <property type="interactions" value="3096"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUK0"/>
    <dbReference type="Gramene" id="CDO99931">
        <property type="protein sequence ID" value="CDO99931"/>
        <property type="gene ID" value="GSCOC_T00029653001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUK0"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUK0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="287"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO99931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="658" mass="73920" checksum="04D601A2127A2CD9" modified="2014-10-01" version="1">MGVPWGSGGGAGGADLLSGRAATMRESLLKSQSITDNMVSILGSFDHRLSALETAMRPTQIRTHAIRRAHENIDRTLKAAEVILSQFDLTRQAEGKILKGPHEDLETYLVAIEQLRENIRFFSSNKSFKSSDGVLNHANGLLNKAISKLEEEFKQLLSSYSKPVEPDRLFEGLPSSMRPSSGSPGEQPDANGKNPSPNGQHHEHHHANAENAVYTPPTLVPPRVLPLLHDLALQMVQAGHQQQLLKIYRDTRSSVLEESLRKLGVEKLSKEDVQKMQWEVLEAKIGNWIHFMRIAVKLLFAGERKVCDQIFEGFESLKDQCFAEVTAGSVAVLLSFGDAIAKSKRSPEKLFVLLDMYEIMRELHSEIETLFRGKACNDIRESALGLTKRLAQTAQETFSDFEEAVEKDATKTAVADGTVHPLTSYVINYVKFLFDYQSTLKQLFQEFENGDGSDSQLAAVTMHIMQALQTNLDGKSKQYKDPALSNLFLMNNIHYMVRSVRRSEAKDLLGDDWVQRHRRIVQQHANQYKRIAWAKILQCLSIQGLTSSGGSGVSADGGNSSGASRAMVKDRLKTFNIQFEELHQRQSQWTVPDTELRDSLKLAVAEVLLPAYRSFLKRFGPLVENGKNPQKYIRYTPEDLDHMLNEFFEGKTLNEPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVA7</accession>
    <name>A0A068TVA7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K+ potassium transporter integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00032052001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVA7"/>
    <dbReference type="STRING" id="49390.A0A068TVA7"/>
    <dbReference type="Gramene" id="CDP00185">
        <property type="protein sequence ID" value="CDP00185"/>
        <property type="gene ID" value="GSCOC_T00032052001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVA7"/>
    <dbReference type="OMA" id="QHECKFI"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVA7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF98">
        <property type="entry name" value="POTASSIUM TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="4">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="285" mass="31780" checksum="8F1A96F2FF705F69" modified="2014-10-01" version="1">MDLETGVSQNPVKKESWRIVLTLAYQSLGVVYGDLSTSPLYVYKSTFAEDIKHSETNEEIFGVLSFVFWTLTLVPLLKYVFIVLKADDNGEGGTFALYSLLCRHARVNALPNCQSADEELSSYKKDIISPAPTTFGARLKSTLEKHRVLQRFLLVLALIGACMVIGDGILTPAISVFSAVSGVELATAKEHHKYIEVPVACIILIGLFALQHYGTHRVGFLFAPVVITWLLCISSIGLYNIFYWNPRVYQALSPYYMYKFLKKTQRGGWMSLGGILLCITGKFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWS1</accession>
    <name>A0A068TWS1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NGN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029496001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWS1"/>
    <dbReference type="STRING" id="49390.A0A068TWS1"/>
    <dbReference type="Gramene" id="CDO99803">
        <property type="protein sequence ID" value="CDO99803"/>
        <property type="gene ID" value="GSCOC_T00029496001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWS1"/>
    <dbReference type="OMA" id="DINEACN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWS1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000053">
        <property type="entry name" value="Protein RNA-directed DNA methylation 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000016">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF8">
        <property type="entry name" value="PROTEIN RNA-DIRECTED DNA METHYLATION 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="6">
        <location>
            <begin position="147"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76947" checksum="4126D47184A795D2" modified="2014-10-01" version="1">MAPSAKGKEKVIDGGKGSSGKRKRNIGGGDDGKTGGRKRKNRGVLQFFDDAAYEVDEDDASDDSFFDDDSLEDEFDTAAAAMQFQSEPSRAPFLPFVPKVEEPTEEELEKMLQERYKPGSTFVTYAEDNYESKRTVEMPEHCPSVKDPIIWKVKCMVGRERHSAFCLMQKYVDLQFLGKKLQIISAFTIDHVKGFIYIEAEKQCDINEACNGLCSIYSSRVAPVPKEDINHLFSVKNKSNGISEGMWARVKNGKYKGDLAQVVAVNSARKKVTVKLIPRIDLKALAEKFGRGITANRTANPAPRLISNSELEEFRPLIQCRRDRDTNKVFEVLDGMMLKDGYLYKKVSIDSLSFWGVTPTEDELLKFEPSRNEEYNDLEWLSQLYGEQKKKRPLLSDKGGGKGEGSSMPSLDTDFEVHDLVFFGRKDFGVVIGTEKDEIFKIIKEGSEGPVVVTIPRKELKNAAFDKKLFTALDQKMKNISINDRVRVLDGPMKDREGIVKKIYRGIIFLYNETVEENSGYICFKAQLCEKVELPGEARNEKGGEQETVVFGDFASSPKSPLSPKQSDQGRDGSRNFNRENNTMFSVGQSLRIRVGPLKGYLCRVLAIRRSDITVKLDSQHKILTVKCEHLAEVRAKSSGISLGEESDSLRPFDLLGTQDGSTDWLDGTAKATGGGNWNAEGFSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWY5</accession>
    <name>A0A068TWY5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00032791001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP00726"/>
        <property type="gene ID" value="GSCOC_T00032791001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWY5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP00726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="118" mass="14065" checksum="2E2CCBC7E4CA6A1A" modified="2014-10-01" version="1">MCSSPFFQSYQKAQKRGPKYRDQHHFIRQKYPYTFCLVTGSPYPPDLFRLDSRSKLPHSIRPYRRRNQPSASLRAPFPTPTIKVWSCFNYGGVRFHLRLVEARKEEGSRVGCIWKWHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ67</accession>
    <name>A0A068TZ67_COFCA</name>
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        <recommendedName>
            <fullName evidence="9">Membrane-anchored ubiquitin-fold protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">May serve as docking site to facilitate the association of other proteins to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="CDP01184"/>
        <property type="gene ID" value="GSCOC_T00034738001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ67"/>
    <dbReference type="OMA" id="RCVCTIL"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ubl_MUBs_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="118" mass="12765" checksum="385065DE2C289CC9" modified="2014-10-01" version="1">MAVEDLVEIKFRLADGSDIGPSKFSPSTTVSSLKEKIIALWPKDKENGPKTTNDLKLINAGRILENNKTLAESRLPVAEVPGSVITMHVVVRPPLAEKNTDKLQDDNPKKGGCGCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Gentianales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Pietrella M."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Bernard M."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Lan T."/>
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                <person name="Perrotta G."/>
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                <person name="Priyono X."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00034492001"/>
    </dbReference>
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    <dbReference type="OMA" id="HPLHEEN"/>
    <dbReference type="OrthoDB" id="207175at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U066"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF157">
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    </dbReference>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39257" checksum="87CB356EB63E57A6" modified="2014-10-01" version="1">MKSVNDNNNGSDASSNNNCNAPNWLGFSLSPHMKMEVTSSSSSSEHHHHQFNHQNQPPPTSTSTDVPTSFCLSSPPHLNNIASPVCFGVSENGGFHHAPLSVMPIRSDGSLCIMEALRRSQTEAMGPNSSPKLENFFGGATMGTHQYGSQDRETMVLSLDSIFYSQNVEPEGEPIRQENPYFSGLQCQDMYQHPLHEENDETRVADCDTQIPTMAGEDLKNWVAVDYSDQHALDQQQLNTAPMVEGGNGSGSGSVGSVGCGDLQSLSLSMSPGSQSSCVTAPRHISPTEAECLAIETKKRSCGKVAQKQPVHRKSIDTFGQRTSQYRGVTRHRWTGRYEAHLWDNSCKKEGQTRKGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0A6</accession>
    <name>A0A068U0A6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidative stress 3</fullName>
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    <gene>
        <name evidence="4" type="ORF">GSCOC_T00036845001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0A6"/>
    <dbReference type="STRING" id="49390.A0A068U0A6"/>
    <dbReference type="Gramene" id="CDP01707">
        <property type="protein sequence ID" value="CDP01707"/>
        <property type="gene ID" value="GSCOC_T00036845001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0A6"/>
    <dbReference type="OMA" id="DASCQMK"/>
    <dbReference type="OrthoDB" id="1938584at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0A6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF29">
        <property type="entry name" value="OS06G0559400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22714" checksum="E5C21B9AC16A25F8" modified="2014-10-01" version="1">MDSFVLNQQSNHGIMDEEKKGLDHDGAVSSSSEVSSSEDSDLFEEVNSSASSSTPTSPTSASASSSSDQLTSGDSGPLQDMSSLLQELPFKRGLSKHYNGKSQSFTSLANVRSLEDLAKPENPYNKKLKSCKSYGVFERHHGSPGHPTARSNHHSCTSSPRLMSKKASRGSCSSLCLKRNSSFIGNRPPLPPPHSSTSTSSFTSQTPLFALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1K2</accession>
    <name>A0A068U1K2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal patterning factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00036560001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls stomatal patterning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1K2"/>
    <dbReference type="FunCoup" id="A0A068U1K2">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1K2"/>
    <dbReference type="Gramene" id="CDP01488">
        <property type="protein sequence ID" value="CDP01488"/>
        <property type="gene ID" value="GSCOC_T00036560001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1K2"/>
    <dbReference type="OMA" id="MMITTSL"/>
    <dbReference type="OrthoDB" id="1922142at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1K2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039455">
        <property type="entry name" value="EPFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109:SF102">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17181">
        <property type="entry name" value="EPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027150904" description="Epidermal patterning factor-like protein" evidence="7">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP01488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="133" mass="14528" checksum="37F2DC43F62AF7E1" modified="2014-10-01" version="1">MAMSSFLASTLLSSTILVVITYLHLLSTTSCLNHNQPPDTVQGLLVEEKTRLGSTPPSCYNKCNNCHPCMAVQVPTMPSHSQLKPRQITRATTTTDSYIDSSSPSSSSPAGNRYSNYKPLGWKCRCGGHFYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U522</accession>
    <name>A0A068U522_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00015151001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U522"/>
    <dbReference type="Gramene" id="CDP03417">
        <property type="protein sequence ID" value="CDP03417"/>
        <property type="gene ID" value="GSCOC_T00015151001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U522"/>
    <dbReference type="OMA" id="ISHIHYI"/>
    <dbReference type="OrthoDB" id="1896560at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U522"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="184"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="456"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="678"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="124397" checksum="461040C283E27A0A" modified="2014-10-01" version="1">MAGALVDALLGSTTEVLVEKAINLASEQIGQFVGFKKDLEKLKDTLTGIRAFLRDAEKKQVTEDSVTRWLEELERVAFDADNLLDDINYEMIRRKVEIRNQMKRKVCLFFSVSNPIAFRCRMAKKIQKINMDLTSIHERRTQLGLQSQNGVRDAPALSPPSGEAFMKDRETDSVTVGASFVGRDDDVSSIVTQLTATCNNETLSVHPIVGLGGIGKTTVAQKVFNDSNIKNHFDKRMWVCVSDIEKKFDANKLFGLMLEKLGVPMAEVAGMDSREAKVQKLKEMLDSEERNGKKSLKYLLVLDDVWNEDPASWNRFLDSLRGISSANGSWILVTTRNEQVATITTISSRPCSLEKLSDHNCWLILEKKAFGSRETPDDLKELGLELAKKCQGLPLAATVLGGMLCNKGSDVWRSILETGLQNIGGDGDSYITKILKLSFDHLPDPSLKKCFAYCSIFPQDFQMERNQLIQLWAAEGFLHSDPRKNICMEEVGNGYFTILLDSNLFQDAEKDDYGNVLYCKMHDLVHDMLQSISDSKTLRLKESTEADFHDKTFRSIDDGLIIFLACLRVLSIASSNAKELPKSIGKLSHLRYLDSSNTPIETLPDSLCKLYNLQTLRLRDCESLRKFPNNFKNLVNLRHFDFFYFDSSSDLMPLEIGQLRSLQTLPFFNTGKEAGRQIGELRNLKHLSGQLVVRNLELVRSKEEAESANLIGKPNIDELILLWNEIDTSRNNDSEYNQVLEGLQAHQNLKGLIIERFFGDKLSTWIGKLGKLVKFELQDCKNCKELPTLGNMPLLRSLHLEGLDSLTSIGPSFYGGSGMHGGSSSQRALKLFPALEYLNLEKMQNLSEWTEATVDDGTVVVFPVLHAVWITDCPQLATFPNHFPCLETLNIENTQNGSSLMTYICSGELRVNNCNNLISFPIDLTRTPSLFWLDISLCEKLTNLPKGKLCSLTSLRYLYIGPFSETTTELHSFLDLFDALPAPHPYFPSVSWLLLYGWPHWESLPAQLQHLFALTTLGLYGFGVKSLPDWFGKLSSLEELQLSNCRKLENLPSHQSMRSLTRLRKLWITHCPLLKERCDLESSSTGPNSERSKISHIHYISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6L9</accession>
    <name>A0A068U6L9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin-18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016321001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6L9"/>
    <dbReference type="FunCoup" id="A0A068U6L9">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6L9"/>
    <dbReference type="Gramene" id="CDP03829">
        <property type="protein sequence ID" value="CDP03829"/>
        <property type="gene ID" value="GSCOC_T00016321001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6L9"/>
    <dbReference type="OMA" id="DAINGCC"/>
    <dbReference type="OrthoDB" id="723894at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6L9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24487" checksum="37FF7D630DB0FC2B" modified="2014-10-01" version="1">MARGERTCCQSFLAFLLKFLNYLQTFLGVSIIIYASLMLNHWYHHHTSVPSTPPPPPHSSYPGLSPSHFSYNLHNLDLHFPADVVLDAGLLNGLQFNSNSLPKPWFIYAFLGVGILMCCITCIGHIAAEAINGCCLCFYAILSTFFILLEVSLETFIAIDHQWETDLPVDSTGELDHLRTFLEENRDVFEWVGIAVVIIQAYIIPHLLLTSYLSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7E7</accession>
    <name>A0A068U7E7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00017834001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7E7"/>
    <dbReference type="FunCoup" id="A0A068U7E7">
        <property type="interactions" value="1215"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7E7"/>
    <dbReference type="Gramene" id="CDP04441">
        <property type="protein sequence ID" value="CDP04441"/>
        <property type="gene ID" value="GSCOC_T00017834001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7E7"/>
    <dbReference type="OMA" id="VIQRSHY"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7E7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000062">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000125">
        <property type="entry name" value="Protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF34">
        <property type="entry name" value="PROTEIN STRUBBELIG-RECEPTOR FAMILY 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654547" description="Protein kinase domain-containing protein" evidence="11">
        <location>
            <begin position="32"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="413"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="721" mass="78105" checksum="7CADE3076B5A0095" modified="2014-10-01" version="1">MEGKKIKSCCIRSPLHLFVVILVAILSGLLAVDGNTDQNDLTALQVLYNVLNSPPQLTGWKSNGGDPCAESWKGITCQGSAVVSLQLSGLGLNGTMGYSLNSLMSLKTLDLSGNMIYDPIPYQLPPNLTSLNLAYNNISGNLPYSLSGMAALSYLNVSHNSLSQSIVDVFNNHSDMAVLDLSSNNLTGDLPQSFISLSNLSTLYLQNNQLTGSLDSLVGLPLTDLNVANNNFSGWIPQELLSIPKFKYNGNLFANGPAPPPPPYTPPPPGRFRNRSSPAPGAPKDSKNHPTHPNTGNGDKGLKAGPIVGIVLGSSVVAFLALIALVFCRRKGKKKEIAARPSSGSLSASTVNKEMQEQRAKSTATAVDLKPPPAEKVMVEKIPGRNGSMKRAKSPITATSYTVATLQTATNSFTQENLIGEGSLGRVYRAEFPNAKIMAIKKIDNAALSLQEEDNFLEAISNMSRLRHPNIVQLAGYCAEHGQRLLVYDYIGNGSLHDMLHFADERSKMLTWNARVKVALGTARALEYLHEVCLPSVVHRNLKSANILLDEELTPHLSDCGLAALTPNTERQVSSTQMVGSFGYSAPEFALSGIYTIKSDVYSFGVVMLELLTGRKPLDSSRPRSEQSLVRWATPQLHDIDALAKMVDPALNGMYPAKSLSRFADIIALCVQPEPEFRPPMSEVVQALVRLMQRASVVKRRSSDESSFAYRTPDHETIDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8L6</accession>
    <name>A0A068U8L6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YlmG homolog protein 1-2, chloroplastic-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016467001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8L6"/>
    <dbReference type="STRING" id="49390.A0A068U8L6"/>
    <dbReference type="Gramene" id="CDP03953">
        <property type="protein sequence ID" value="CDP03953"/>
        <property type="gene ID" value="GSCOC_T00016467001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8L6"/>
    <dbReference type="OrthoDB" id="2066at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8L6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010020">
        <property type="term" value="P:chloroplast fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219:SF10">
        <property type="entry name" value="OS07G0185300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="YLMG HOMOLOG PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="CCB3_YggT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27388" checksum="BD6154CEEDE4CC67" modified="2014-10-01" version="1">MASQSIVLQNPAVLSPYISTAVISPPLPRKHPNIISCRQPACTAAVSAPNAHRSTGPTQPLLRVVSVPPSEKPKTIASSSSAPVHHYPSTDKSQNKNSPPPQSSSSLLLTTSTRTATTLLVIALAASKLLAGRIQAIYGLLPQVEPLIYSSAAPAFFAAIGEYPTTVRLDTPFAILAGGMAKWLDIYVGVLSLRCLLTWFPNIPWDKQPLSAIRDLSDPYLSLFRSVIPPVFDSLDLSPLVAFTVLGTIGTILRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8Q0</accession>
    <name>A0A068U8Q0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00018712001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8Q0"/>
    <dbReference type="STRING" id="49390.A0A068U8Q0"/>
    <dbReference type="Gramene" id="CDP04667">
        <property type="protein sequence ID" value="CDP04667"/>
        <property type="gene ID" value="GSCOC_T00018712001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8Q0"/>
    <dbReference type="OMA" id="TLYIMAD"/>
    <dbReference type="OrthoDB" id="1710643at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8Q0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11110" checksum="84C48A5DA251EDEA" modified="2014-10-01" version="1">MDFENYYEISLVADFINAHNFSRVALQFPDELLKDSRKVVSALRQELHRLLKNSDESRATAKLYVMADTTYGGCCVDEVGAAHVKADCVIHYGHSCLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9K9</accession>
    <name>A0A068U9K9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020186001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9K9"/>
    <dbReference type="FunCoup" id="A0A068U9K9">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9K9"/>
    <dbReference type="Gramene" id="CDP05220">
        <property type="protein sequence ID" value="CDP05220"/>
        <property type="gene ID" value="GSCOC_T00020186001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9K9"/>
    <dbReference type="OMA" id="TARNQSH"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9K9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00122">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038945">
        <property type="entry name" value="MBD13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34067">
        <property type="entry name" value="OS04G0193200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34067:SF20">
        <property type="entry name" value="OS08G0206700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="MBD" evidence="7">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="480" mass="52968" checksum="18FBAEADE36A4032" modified="2014-10-01" version="1">MGHEKSSDDWLPAGWKVEVRVRKTGKKDKCYVDPSNERKFYSKPEVLRYLKDVGVSQPVHEETQNKSISSRLAIKFVVKEEAAEGLPAGWIKETRVTQKGNKIRRDPYYIDPESGHLFRSMKEVFRYLDTGKMGGLASMGNEQSSINLESRDNSLPSSVEIEEKRTADSKAEKQFIGNEIQKSETAAIDNDNLPEANKLKEREKKESSSESTTVTEVLVENSHTGIGLQATNRKKRKLNDKKGADLPRRTSKRLAGVRVNLSLESNSHTRVRRAAGRQMTETEVNCADKGDNIADVQEQVERVTIGTEAADSKQDSVDALPPRDVTFPEELVKLGVADCKGDEKPEAPLGICLKDLCQDPCIEFAIKTLMGAIPIGDETKVSMNQGSSSNLPDAVPVPGSSVDSPSKDIWSDPCFEFAVKTLTGEIDTNMETIQRQPPHNSSETIESGLTNNSMSAGVSHASVSSRHSSVAEFPVHKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9T9</accession>
    <name>A0A068U9T9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00017748001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9T9"/>
    <dbReference type="FunCoup" id="A0A068U9T9">
        <property type="interactions" value="2046"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9T9"/>
    <dbReference type="Gramene" id="CDP04378">
        <property type="protein sequence ID" value="CDP04378"/>
        <property type="gene ID" value="GSCOC_T00017748001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9T9"/>
    <dbReference type="OMA" id="DTQTWIT"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9T9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000020">
        <property type="entry name" value="cardiolipin synthase (CMP-forming), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP04378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="354" mass="38784" checksum="42274580A1A1859A" modified="2014-10-01" version="1">MAFFRSILKTLISQSTKSPLQNPNSVSSSARTFVSLCSSSQSYISHNSNSNIIKNPFFLRPHFLSPIPSSTFGPLFLSSPPWKLSQSATPLHLQCDVALLNLSPRVPYALNNIITYKLRFQDLNSKEKKYSEGFNGSKLDHTDSDALVKVTDSYLNLPNFISFGRLVSGPLLGWMITHEMYLSAFVGLGISGVTDWLDGYLARKMGINSVVGSYLDPLADKVLIGSVALGMVYKGLLHPGLVALVVLRDVALVGGAVYKRASSLQWQWKSWFDFFNLDGTCPEKVEPLLISKLNTVLQLVLVAAALLQPEFGSEETQSYITYLSWLVALTTVGSTAAYGIQHLKTGSKSMATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9V3</accession>
    <name>A0A068U9V3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00020224001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the splicing factor SR family. RS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9V3"/>
    <dbReference type="FunCoup" id="A0A068U9V3">
        <property type="interactions" value="976"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9V3"/>
    <dbReference type="Gramene" id="CDP05246">
        <property type="protein sequence ID" value="CDP05246"/>
        <property type="gene ID" value="GSCOC_T00020224001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9V3"/>
    <dbReference type="OMA" id="RRPEKHG"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9V3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12234">
        <property type="entry name" value="RRM1_AtRSp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12466">
        <property type="entry name" value="RRM2_AtRSp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000294">
        <property type="entry name" value="Serine/arginine-rich splicing factor RS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000299">
        <property type="entry name" value="Serine/arginine-rich splicing factor RS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP05246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="40557" checksum="F6750DB722418707" modified="2014-10-01" version="1">MRSIFCGNFEYDARQSDLERLFQRYGRVDRVDMKSGFAFVYMVDERDAEDAIRGLDRIEFGRKGRRLRVEWTKQERSRKPESSKASSGLRPSKTLFVINFDPYHTRTRDLERHFDPYGKILNVRIRRNFAFVQYESQEDATKALDATNLSKLLDRVITVEYAVKDDDDRRSGYSPDRSHGRSPKRSYDGGRSPSPYGRERASPDYGRGHGRSPYRRERVSPNYGQGPCPVRSGRERNSEHGSGRQPSPRKERNSDHSHGHSPSPRRERLSSENGHNNSPRERRRPKKEHDISPNPQREKRERMSPDDYRNGRSPSSNPELTDSPGNGGAESPLPQRQRSRTPPARERSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9X3</accession>
    <name>A0A068U9X3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Defensin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017794001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9X3"/>
    <dbReference type="Gramene" id="CDP04413">
        <property type="protein sequence ID" value="CDP04413"/>
        <property type="gene ID" value="GSCOC_T00017794001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9X3"/>
    <dbReference type="OrthoDB" id="1444586at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657773" description="Defensin-like protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9730" checksum="D7D677453DB6CB59" modified="2014-10-01" version="1">MKTAFSLVVFLLALCVMEPCVLFGVEARRVVFVHCNSDDDCQFICPPGTTSFKCVSRICECHPPENSAAKPETANDAKDLNARPKEAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAN3</accession>
    <name>A0A068UAN3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00020347001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAN3"/>
    <dbReference type="FunCoup" id="A0A068UAN3">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAN3"/>
    <dbReference type="Gramene" id="CDP05342">
        <property type="protein sequence ID" value="CDP05342"/>
        <property type="gene ID" value="GSCOC_T00020347001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAN3"/>
    <dbReference type="OMA" id="PRIHLGV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000013">
        <property type="entry name" value="NADPH-dependent codeinone reductase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="318" mass="36016" checksum="6A634C9AB512879D" modified="2014-10-01" version="1">MRDIYTRQVRLNNGVWMPVVGLGTYSSENDSETTQQAVRMALQMGYRHFDTAKIYGSEPALGNALRSAISDRMIQREDVFVTSKLWSSDHHDPVSALEETLQKLGLEYVDLYLVHWPVKLKPGVLNPVPGEEDFDILDLESTWLGMEKCLAMGLCRCIGVSNFSSRKVQQLLDFATVPPAVNQVEMHPMWRQRKLREVCRKHNIHVSAYSPLGAPGNCWGSTAVVDHPILKSVALKHKATPAQVALAWGMSKGSSVIVKSFNQRRMKENIGALHLALDDSDTLKIQKMEEWKIMRGDFFTNETTSPYRTIQDLWDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB12</accession>
    <name>A0A068UB12_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00020941001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739102">
        <property type="protein sequence ID" value="CDP05710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB12"/>
    <dbReference type="FunCoup" id="A0A068UB12">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB12"/>
    <dbReference type="Gramene" id="CDP05710">
        <property type="protein sequence ID" value="CDP05710"/>
        <property type="gene ID" value="GSCOC_T00020941001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB12"/>
    <dbReference type="OMA" id="ENVANHK"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000007">
        <property type="entry name" value="50S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_uL30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="6">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="108" mass="12534" checksum="28C55BE078E8A94A" modified="2014-10-01" version="1">MSAYQAFKACVPIEWSDKLYITLVRGMPGTRELHRRTLEALHLRKCNRTVVRKNTPTVRGMLQQVKRLVAIETKEMYEARKQREANQRALRPPLVISHHPAPKTDSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBH6</accession>
    <name>A0A068UBH6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00021112001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">cv. DH200-94</strain>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080156">
        <property type="term" value="P:mitochondrial mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="152" mass="16442" checksum="33D5E15044965108" modified="2014-10-01" version="1">MALRAAAKTAATAATAASPRGLRSLLFSTSTFPFNLPQSQTEKPPPAEPSTNLFFMICLSKRTTTEGLRTAFEKFGQVVDAKVVTDRASGFSKGFGFVRYASLEDAAAGIEGMDGKFLDGWVIFAEYARPRNTLPPPQNSFPHGVNNTRFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCH2</accession>
    <name>A0A068UCH2_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">Cell number regulator 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00020343001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCH2"/>
    <dbReference type="Gramene" id="CDP05338">
        <property type="protein sequence ID" value="CDP05338"/>
        <property type="gene ID" value="GSCOC_T00020343001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCH2"/>
    <dbReference type="OMA" id="EDMNSFW"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26539" checksum="696DAE113038036C" modified="2014-10-01" version="1">MAEGGGNPSRYVKLTKEQAAPSEDIKPGELNQPIEVPQLGVRKCNECGQPLPESFEPPADEPWTTGIFGCTEDTESCWTGLLCPCVLFGLNIEKLRDDTPWTTPCVCHAIFVEGGIALAAATAAFYGIDPRTSFLICEGLLFSWWMCGIYTGLARQSLQKKYHLKNSPCDPCMVHCCMHWCALCQEHREMKGRLSDDAAMPMTVVNPPPVQEMSAAPDDRDSAPSSEKSKEHTNLEMQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDH9</accession>
    <name>A0A068UDH9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">starch synthase</fullName>
            <ecNumber evidence="4">2.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00023115001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
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                <person name="Bernard M."/>
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                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
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                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
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                <person name="Pallavicini A."/>
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                <person name="Pot D."/>
                <person name="Priyono X."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP06327">
        <property type="protein sequence ID" value="CDP06327"/>
        <property type="gene ID" value="GSCOC_T00023115001"/>
    </dbReference>
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    <dbReference type="OMA" id="WSHILLM"/>
    <dbReference type="OrthoDB" id="2018403at2759"/>
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    <dbReference type="UniPathway" id="UPA00152"/>
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        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000260">
        <property type="entry name" value="Starch synthase, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001905">
        <property type="entry name" value="PRK00654.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46083">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46083:SF2">
        <property type="entry name" value="STARCH SYNTHASE 4, CHLOROPLASTIC_AMYLOPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0750">Starch biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Starch synthase catalytic" evidence="11">
        <location>
            <begin position="575"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="237"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP06327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1071" mass="121256" checksum="4C154E363B9D42B8" modified="2014-10-01" version="1">MEAKLASSFLGQRWWCYGGGGLDYCKQGNVRFCPSVSHRFVPASCKMRQRNHSSQNKRQQAKKLYPDRPTGVNFPATSDEDSDMENLSNDGITSLKETADDLDAAEKAEQTDNPTSDDLLATSGEDSDTEKFSKNGITILKDTADDLDAEQTEILPNNNITGLKGDANGMDFASEAELSNENMSLTLLNEIRPVSIAANGEDELSNVHLSGLIGMIRNAEKNIHLLNHARITALEDLEKIRSEKEALQGKMNVLEMKLAETDEKLRVAAQQKMHVELLEDQLEQLRNELLARGDNEGSMHDKHVSLPFSLSEELDVLRTENLSLKNDLQALKADLGDIKGTDERVQMLEREKSFLESSLKGLDNKLAASQEDVSKLSMLKFECKNLYEKVEHLQTLLDKAAKQADQAIFVLQENQELRKKVDKLEESVEEANVYKLSSERLQHYNDLMQQKLRILDERLQKSDEEIHGYVQLYQDSVKEFQDTLSNLKEESKRRAEDEPVNDMPWEFWSQLLLMIDAWLLEKKISTDDAGLLREMVWKRDGHICNAYMSCKEKKQHEIISTFLRLISSPKSSELHVIHIAAEIAPVAKVGGLGDVVTGLGKALQRRGHLVEIILPKYDCMQYELIRDLRALDAVVESYFDGRLHKNKIWTGTVEGLPVYFIEPHHPGNFFWRGQFYGEHDDFKRFSFFSRAALELLIQAGKKPDIIHCHDWQTAFVAPLYWDIYAPKGLNSARLCFTCHNFEYQGTAPASELASCGLDVHHLNRPDRIQDNSAHDRVNPIKGGIVFSNIVTTVSPTYAQEVRTAEGGRGLHATLNSHAKKFVGILNGIDTDAWNPARDTFLKVQYSAFDTQGKTENKEALRRKLGLSSANIGQPLVGCITRLVPQKGVHLIRHALYRTLELGGQFILLGSSPVSHIQREFEDIANQFQSHENARLLLKYDESLARFIYAASDMVVIPSIFEPCGLTQMIAMRYGSIPIVRKTGGLNDSVFDVDDDTIPEEFRNGFTFLTADEQAFNNALERAFFHYKNNSEFWRKLVQKVMRIDFSWDSSASLYEELYEKSVARARAANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDU9</accession>
    <name>A0A068UDU9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00021092001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDU9"/>
    <dbReference type="FunCoup" id="A0A068UDU9">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDU9"/>
    <dbReference type="Gramene" id="CDP05803">
        <property type="protein sequence ID" value="CDP05803"/>
        <property type="gene ID" value="GSCOC_T00021092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDU9"/>
    <dbReference type="OMA" id="HMYISEV"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDU9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022175">
        <property type="entry name" value="BCAS3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF7">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 18F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12490">
        <property type="entry name" value="BCAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="4">
        <location>
            <begin position="69"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="BCAS3" evidence="3">
        <location>
            <begin position="622"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="891" mass="96666" checksum="23181F801C9A52F9" modified="2014-10-01" version="1">MRNDGQKPGGGNSGGGGSSGGGFIPTSFKALSSYLRIVSSGASTVASTVRSAASAASAIVERDSDSFHDQVHWAAFDNLQCDGHITRQVLLLGFRNGFQVWDVEDVSNVHNLVSRQDGPVSFMQILPKLLASKQDRDKFANSRPLLLICADGCFPGGSDFQECSSRSGTIHYGHELPNCSGVPTVVCFYSLRSHSYVHQLKFRSVVHLVRCSSRIIAVLQASQIHCFDAATLETDYNILTNPIPLGCGSGCIGFGPLALGPRWMAYSGSPVGNSNSGHVSPQQLTPPRLPSPASNGSLVAHYAKESSKQLAAGLMTLGDMGYKKLSRYYSELLPDGNNSQSGSPRLSGHGVANSQLHDVENDGMVVVRDIVEKTLITQFRAHKSPISSLCFDPTGTLLVTASVHGHNINVFRIIPRHTSGAGSGASYVHLYRLQRGFTNAVIQDICFSRDSEWILISSSRGTSHLFAISPFLGSSGIQSADVCLSSKGSGLGIMMRSPACSTPHSGAQVYDQQCFRTSDPPVTLSVVSRIRSGNNGWRNTVTGAAAAASGRMNSPAGAIAAAFHYYKGSDSYLDTSFLKTNCHLLVFSSPGCLIQYAMRVSSGLDSLTTMHELGMGRDPCLENDAKLVVEAMRKWNICHKQNCKERDENVDIYGENGYYDSSKVFPEGIRKKGVYSEARNTVSKDKMASEEKYHLYLSEAELQMHQHRVPLWMKAEIYFQTMATDGINTSEESAFEGEIEIERIPTRMIEVSSKELVPVFEYLQAPKLQPGRQVLNRSKDRQLLYQRSGMSENRKLAYMGSSGSLDSMSGGLAVTELHNGAEETGWVGLQVPTNTTKGFVNTADYSKANGRLEIVNNRESSVTETQFSFVNNSIGVLTSENQFEGSGDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEN5</accession>
    <name>A0A068UEN5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00023632001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEN5"/>
    <dbReference type="FunCoup" id="A0A068UEN5">
        <property type="interactions" value="2699"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEN5"/>
    <dbReference type="Gramene" id="CDP06697">
        <property type="protein sequence ID" value="CDP06697"/>
        <property type="gene ID" value="GSCOC_T00023632001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEN5"/>
    <dbReference type="OMA" id="SKTGCEH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEN5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000186">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985">
        <property type="entry name" value="OS07G0668900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47985:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PBL7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="73"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP06697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="390" mass="43274" checksum="C68BD215FF1164BE" modified="2014-10-01" version="1">MGWFPCSGQSHSKLSSKKKRKIKDPLHPIQPSPEKSKVNAPLNSQVNSKDGGSNQIAAKTFAFRELAAATRNFRADCLLGEGGFGRVYKGRLENSNQIVAIKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEYMPLGSLEDHLYDATPDKKWLDWNTRMKIAAGAAKGLEHLHDKASPPVIYRDLKCSNILLGEGYHPKLSDFGLAKLGPVGDNTHVSTRVMGTYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIITGRKAIENSKTAGEHNLVAWARPLINDRKKFSQMADPMLQGQYPMRGLYQALSVAAMCVQEQPNMRPVIADVVTALSYLASQKYNPTQSSQWAPATPPRTKREGEKREHGDSGYEKRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFM3</accession>
    <name>A0A068UFM3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">phospholipid:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00024078001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + a 1,2-diacyl-sn-glycerol = a monoacylglycerophospholipid + a triacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:14057"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:136913"/>
            <dbReference type="EC" id="2.3.1.158"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.158" evidence="9"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFM3"/>
    <dbReference type="FunCoup" id="A0A068UFM3">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFM3"/>
    <dbReference type="Gramene" id="CDP06999">
        <property type="protein sequence ID" value="CDP06999"/>
        <property type="gene ID" value="GSCOC_T00024078001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFM3"/>
    <dbReference type="OMA" id="CWLIGYL"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFM3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000160">
        <property type="entry name" value="Phospholipid:diacylglycerol acyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="667" mass="73867" checksum="13AB230E7A0A0D14" modified="2014-10-01" version="1">MASILRFRKLCILVPVNPISAVEQVSEKPQVKKNKRQPKQWRCIDKYCWMIGYICTTWWLILFSFNCLTANLPGLKVPEPPGARLRREGLTALHPVVLVPGIVTGGLELWEGKPCSEGLFRKRLWGGNFAEILKRPLCLLEHLSLDNETGLDPPGIRVRAVAGLVAADYFAPGYFVWANLIENLAKIGYEGKNMFMAAYDWRLSFQNTEIRDQTLSRLKSQIELMYLTNGRKKVVVVPHSMGVIYFLHFLKWVEAPPPMGGGGGPDWCNKHVKAIMNIGPAFLGVPKAVGSLLSAESKDVAFLRAMAPGLFSSKTLGLQTLEHAMRVGRTWDSVISLLPKGGETIWGNLDWSPEEGHVCDSLKKRQLQASASDDKGNNNDSRRAFHVKELTKYGRIVSFGKNASELPSSQFSPLVFKVASVDHGSSTNSAGVSCGKVWTEYNEMSHDSIRRVAENKAYTAETVMDLLRLVAPKLMQRAEAQFSHGIAENLDDPKYNHYKYWSNPLETKLPNAPDMEIYCLYGAGLPTERSYVYKLTPPDRCKSIPFQIDGSADGSNSCLKGGVYFGDGDESVPVLSGGFMCAKGWRGRTRFNPSGIATYIREYHHKAPRSLLEGRGLESGSHVAIMGNVAFIEDVLRVAAGASGAGLGGDKVYSDIMRMSERIDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGW0</accession>
    <name>A0A068UGW0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2 8">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00025173001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2 8"/>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGW0"/>
    <dbReference type="STRING" id="49390.A0A068UGW0"/>
    <dbReference type="Gramene" id="CDP07790">
        <property type="protein sequence ID" value="CDP07790"/>
        <property type="gene ID" value="GSCOC_T00025173001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGW0"/>
    <dbReference type="OMA" id="ALDWGQE"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGW0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:cytokinin riboside 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000013">
        <property type="entry name" value="Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF51">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE LOG4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP07790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="229" mass="25016" checksum="E86E39AC7D9828BA" modified="2014-10-01" version="1">MKGDEGTSSANEAVKKKFNRICVFCGSRAGYKSSFSDAALQLGKELVNRKIDLVYGGGSVGLMGLVSKTVYEGGCHVLGIIPRALLPHEISGKTYGELKIVADMHQRKSEMEKHADAFIALPGGYGTMEEFLEMITWAQLGIHEKPVGLLNVDGYYDGLLALFDKGVEEGFIADSARHIMALADTAEELIKKMEEYAPIHERVAPRQSWEVDQLLESTTTTQVGESLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH75</accession>
    <name>A0A068UH75_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025430001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH75"/>
    <dbReference type="Gramene" id="CDP07920">
        <property type="protein sequence ID" value="CDP07920"/>
        <property type="gene ID" value="GSCOC_T00025430001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH75"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="6977" checksum="C97E75B7B28D81D3" modified="2014-10-01" version="1">MGASLLCKRFQISNVIIDIELLCFKIIGIILQDMAFLDFIDLFIIHTICADLVRFGNKVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ96</accession>
    <name>A0A068UJ96_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027631001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <begin position="19"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="761" mass="82973" checksum="F76EFA4290C7365F" modified="2014-10-01" version="1">MDTYSSGEELIIKARKPYTITKQRERWTEEEHNRFLEALKLYGRAWQRIEEHIGTKTAVQIRSHAQKFFTKLEKEALAKGTPIGQALDIEIPPPRPKRKPCNPYPRKMSIGLPTSQVESKDGKLGNPSSSLPQAEHILDLENEPAAEKPEGEKFEDAKENRDEGESNKCFNLLQASPGIPPSSANTCSSTMASGKSSVLMEFVPIFNEVVNRDETTESYVTVEAGPNQNSDKFYTIQSFEENGTCNSRNWANAHSLNDKPAQNKGNVPEQSENIDTSPKNGVQSPKSQPRHVAVHILDGSLRMNAPNVSAHMPYEESLFLEIGGVNSNIFSTLSSSATSEHQSSASRFSISEPFVGFNPILTPVHQEDYHSFLHASSTFSNLIVSALLQNPMAHAAASFAASLWPCSTTEAPAESPGGGTGGFTARQMNAAPSITSIATATVAAATAWWTAHGLLPLCAPFHMGLNYVPVSGSAVPAVTNQPRVDITERREEISGPPLDAKHLEPEYCEALQEQHSTSKSPTLSLSDSVESKGLNSSNKSTAKKTDSAAVTDLNDSNKPKGRKRVDRSSCGSNTPSSSEVETDALEKLEKGKEELREPVVSQPTADSSGRRSRSSSSTSDSWKEVSEEGRLAFQALFSREVLPQSFSPPHDSKNKGKNTNEKNKDNADGKGDKGYLLDLNGKMCTNSATHQDLENNLSLRCLNITEGGLLTTGKLKMRRTGFKPYKRCSVEAKENRLVSAGSQEEEKGTKRIRLEGEASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJB1</accession>
    <name>A0A068UJB1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027096001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="NT-C2"/>
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        <property type="entry name" value="PMI1_PMIR1-2_C"/>
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    <dbReference type="PANTHER" id="PTHR33414">
        <property type="entry name" value="PROTEIN PLASTID MOVEMENT IMPAIRED 1-RELATED 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21745">
        <property type="entry name" value="PMI1_PMIR1-2_C"/>
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    </dbReference>
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        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="1">
        <location>
            <begin position="101"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127913" checksum="E15474C78979A40C" modified="2014-10-01" version="1">MLSWLFSFLNWRNTEPNKYLISMVISKDDTVMSNDEALSSGQLLRDIGEISQALYLHKDPSKSVHLQSKHQSIFGTKASVRDVFQKEKKSSIWGWKPLKALTHIRSHRFNCFFFLHVHSVEGLPSNFNDLILCVNWKRKNEVFKTHPVRVFEGIAKFEETLMHQCSVYVSRNGPQNSAKYEPKLFLLQASIIGAPTLDIGKHWVDLARLLPLTVEELEEEKRTSGKWTTSFKLKGKAKGAILNVSFGFSILGDNPFDPRHFLTVSDMPKDSGQTPIAISSDCDQSSSNIALRRSGSVPRKSYNGHQHVSSQSLDMKYLSEVFPNQNSELARSINFLYQKLDEGKFGNLKEVDGFHENLVPFNSKFASSGNGFDDSDFIVIDQGVELSVKDDWKLDHNSTECFNKPVIETIDVAEIFQEDMTDFSAKGEPNSNHLLDCSNSCESAIQSKCEENNVYGKESTVEESTMVSCKFIASESAEFDMSSNISKCIEEETYMNTESSCGASKLVRSLSLDDVTESVANEFLDMLGFGHNPRDMTSDSEPESPRGHLLKQFEMEFCAFENPILDLDAASERIEVSGVARTGSGRVACSDDFDLSLVIQEAEKEYNRVTQSLRSRRNAKMLENLETETLMQRWGLNDKVFQNSPRITSDGFGSPVYFPPEEPSRLPALAEGLGPTIQTKSGGLLRSMSSSLFRRAKNSAKLIMQVSNAVVLPAVMGSNVVEILQCWASGGAEDMFAKTNELMPLEDITGRTMEQVILETEHSSEVIKRFDQSASLNDFRVKDHSFVLEKNDEGSLFGQNAPNLGSITEKVYSDYVSLEDLVPLAVANFEALSIEGLRIQCGWSDAEAPSCIRPQFTENWTSVGQNVKLGGVMGSLGPTPLQLLDVKREDGIAELIKFSISLNEWIRLDAVDIDYENEVDGEMLKILAAHHADLFDLGGLQMTRNGQRVKLSGSNSHLFGNNFTLALRLQLRDPFRDFEMVGSSILALAQVERICIPVHDEMHNTNIETDLSNKKDDLNEEFVMEGTSAEENHKCINAPFISRFKISGVHIAGFNVEPNGRGMLINPRQLQSGSRWLLSSGMNRTSKRPFSKSSAITKPSSQLLQKQTCDTLWSISSEVQSAAARWKHFGAQNIHVRNPDIAFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJN6</accession>
    <name>A0A068UJN6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00027788001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJN6"/>
    <dbReference type="SMR" id="A0A068UJN6"/>
    <dbReference type="FunCoup" id="A0A068UJN6">
        <property type="interactions" value="2357"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJN6"/>
    <dbReference type="Gramene" id="CDP08720">
        <property type="protein sequence ID" value="CDP08720"/>
        <property type="gene ID" value="GSCOC_T00027788001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJN6"/>
    <dbReference type="OMA" id="PNIASMY"/>
    <dbReference type="OrthoDB" id="808734at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000001">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 28, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP08720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="148" mass="16502" checksum="718FDFF25F9D508C" modified="2014-10-01" version="1">MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPPDSPYAGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYEATARSWTQKYAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJQ2</accession>
    <name>A0A068UJQ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027476001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJQ2"/>
    <dbReference type="STRING" id="49390.A0A068UJQ2"/>
    <dbReference type="Gramene" id="CDP08532">
        <property type="protein sequence ID" value="CDP08532"/>
        <property type="gene ID" value="GSCOC_T00027476001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJQ2"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJQ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="45" mass="4810" checksum="2EF97AB3CA9CF622" modified="2014-10-01" version="1">MSAESASAIQGSQVDLLDFVDWSGVECLNQSSTHSLPNALKKDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKC9</accession>
    <name>A0A068UKC9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol transfer protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028068001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKC9"/>
    <dbReference type="STRING" id="49390.A0A068UKC9"/>
    <dbReference type="Gramene" id="CDP08931">
        <property type="protein sequence ID" value="CDP08931"/>
        <property type="gene ID" value="GSCOC_T00028068001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKC9"/>
    <dbReference type="OMA" id="QHNVHEL"/>
    <dbReference type="OrthoDB" id="10053061at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKC9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000028">
        <property type="entry name" value="Phosphatidylinositol transfer protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="253" mass="28911" checksum="25EB4B6639D08501" modified="2014-10-01" version="1">MPLTLEEYQIAQMYMVMKMQQENTAGTEGVEVLENRPFEDDEFGKGQYTLKLYRLQSKAPLWLTTFAPADALVMQEEAWNSYPRCKSVIQCPYFTKFRLTIETIHKADNGQSENVHGLSKNELAAREVEVLDIASTASDYWSYIIGRNNIDFSTFQSARTGRGPLLEGWQNSCDPVMTAYKLVTIDAPYWGFGSRLEQALMAGERALFLESHRNSFAWTDEWFGLTVEVMRELEQQSDTSLNEKFGGQCLVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL23</accession>
    <name>A0A068UL23_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3741 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028429001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL23"/>
    <dbReference type="FunCoup" id="A0A068UL23">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL23"/>
    <dbReference type="Gramene" id="CDP09200">
        <property type="protein sequence ID" value="CDP09200"/>
        <property type="gene ID" value="GSCOC_T00028429001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL23"/>
    <dbReference type="OMA" id="WLQKEIC"/>
    <dbReference type="OrthoDB" id="1924799at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL23"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032795">
        <property type="entry name" value="DUF3741-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35499:SF1">
        <property type="entry name" value="DUF3741 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35499">
        <property type="entry name" value="OS05G0128300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14383">
        <property type="entry name" value="VARLMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="2">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="456" mass="51280" checksum="D4BBE1E2DBD8A70F" modified="2014-10-01" version="1">MKFLTSSSSTASSTITSTTASTSFGSNVHNSRSTPAGCIAGVFRRLLCLKSLPTHPSDHFKDTDHDSVSVELDRLQCTSTVSAEERVESSAAPSIVARLMGLESLPQTDFSAAEKSPSSIERSRSMNSVDLMKELVSIQGRHRRVKSFRETAPTFLELEDEDFFVLSFETIVGEESRKSETRSKQKKQRGRGANDKSQSSTGRRENVYEKNKENQDPMNVLNNQKQERTTDSRKASQRAVSEVMSDGIRPLSISSSQNSFEGKEVESRAKPINRKPENEFRRRMKKRKDDCLPVKKVESDCSDSENSSPNSVLDIVKFPCDPEVTSSEGLSRLTNSKSRRTLTEELENYRKLNHQYVDKSLTSNASGKSRTRSEGKCVELRKNDRGRQNNSANMWGENCELAEKDTIRSNWIPLSKEIQRFEGYREISGEFEIQIFEELLGELVDQLGGGTCHQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULM4</accession>
    <name>A0A068ULM4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027462001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULM4"/>
    <dbReference type="STRING" id="49390.A0A068ULM4"/>
    <dbReference type="Gramene" id="CDP08523">
        <property type="protein sequence ID" value="CDP08523"/>
        <property type="gene ID" value="GSCOC_T00027462001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULM4"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1412">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 83A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="294" mass="33167" checksum="70D832C4E26ADB88" modified="2014-10-01" version="1">MPANLESLIKSINQSDSDKITCIIADKTMGLALEVAKKMRIKAVAFWPASALQLTQIFSIPKLIDDGIISSTEKENKLFIVITLQTLCCAVLKKQMIKLAPTTPDMKPEHLLWTCFSDPTLQNFAFDTLLKSIRTAKLADWLFCNTSCELEPAAFTLFPQLLRVGPLLASNRLGKSVGYFWPEDSDCWHGLISSLRNLSFISCASSACSLRKCGCTFIFLSVDHIVSCCPCPVYNSLELHWPVHLFLIPHHSCVDIPVYPLYQASRFKFSPFCWMYQLLPNSAYPFTTSQRLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMQ6</accession>
    <name>A0A068UMQ6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030135001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Magnesium transporter that may mediate the influx of magnesium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMQ6"/>
    <dbReference type="FunCoup" id="A0A068UMQ6">
        <property type="interactions" value="1554"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09701">
        <property type="protein sequence ID" value="CDP09701"/>
        <property type="gene ID" value="GSCOC_T00030135001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMQ6"/>
    <dbReference type="OMA" id="WTNLYDL"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMQ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF35">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="424" mass="48005" checksum="6B0842294964C1FC" modified="2014-10-01" version="1">MRRTGLPARDLRILDPLLSYPSTVLGRERAIVINLEHIKAIITAQEVLLNSQGPSVTSFIEELQRRILRHHQARSQEARGNGNDVDWSNLYDLEEPQSRNVSFRNKDEEGRTEGKQQNAENRDGLKLLPFEFVALEACLEAACSVLDNEARTLEQEAHPALDKLTTKISTLNLERVRQIKSRLVAITGRVQKVRDELEHLLDDDEDMAEMYLTEKLEQQQLDDSSVSSINEQDELDDEANQQDIDERTRANISYEGNGGPTSYDAGLQNMDNTREQLIAAARTLSKDSRGTRTSTTQSAISKQLDVEELEMLLEAYFVQIDGTLNKLSTLREYVDDTEDYINIMLDDKQNHLLQMGVMLTTATLVVSAFVVVAGIFGMNIHIELFDPDKAGMPQFLWTVGGGTTGTIFLYVIAMIWYKQRRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMZ7</accession>
    <name>A0A068UMZ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00030066001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMZ7"/>
    <dbReference type="STRING" id="49390.A0A068UMZ7"/>
    <dbReference type="Gramene" id="CDP09657">
        <property type="protein sequence ID" value="CDP09657"/>
        <property type="gene ID" value="GSCOC_T00030066001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMZ7"/>
    <dbReference type="OMA" id="WVFKGWI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000468">
        <property type="entry name" value="PTI1-like tyrosine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="77"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP09657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="400" mass="43903" checksum="2403B97D8C49D1D8" modified="2014-10-01" version="1">MGICLGKPAKLANASSSQFLETKTEPGNVKQDSTPPNQQSLSGSTNRPLQVLKPDPSISSNLKSYNFNDLKTATKNFRPDSILGEGGFGFVFKGWIDEHTLAASRPGSGMVVAVKKLKTESFQGHREWLAEVNYLGQLHHQNLVKLIGYCSESDKRLLVYEFMPRGSLENHLFRKGVQLMAWATRMKIAVDVARGLSYLHSLCANVIYRDMKASNILLDSDFTAKLSDFGLARDGPSGDRTHVSTRVMGTRGYAAPEYVATGHLTPKSDVYSFGVVLLELLTGKRAMGDENIGGNDETLVDWAIPFLGDSRRVTRIMDTRLGGQYNKKAAQAAAGVALQCLHIDPKLRPAMPEVLTNLEVLLTAKDSPRLPLQSKLDTNVTLPEKSTHPQKNARASSHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNI8</accession>
    <name>A0A068UNI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Palmitoyl-protein thioesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030546001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP10011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNI8"/>
    <dbReference type="STRING" id="49390.A0A068UNI8"/>
    <dbReference type="Gramene" id="CDP10011">
        <property type="protein sequence ID" value="CDP10011"/>
        <property type="gene ID" value="GSCOC_T00030546001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNI8"/>
    <dbReference type="OMA" id="CTSPVCQ"/>
    <dbReference type="PhylomeDB" id="A0A068UNI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38866" checksum="B93F2004DFBC808F" modified="2014-10-01" version="1">MHMHKAKVDEDKCFASLSLLHILVSHTNIYSIICTSVYPFFFQTGNQEFEDSMATYSPFIIFIVSAFSLVSLCSSIPFILLHGRLGDSCSNPGPVLYTQQLRYLSGSVGFCLEVGNGAITSWDTPLEAQVEEVCRKVKATPELQNGYNIVGQSQGNLVGRGLVELCDDAPPAINFISLGGPHAGVASIPNCSQFDALCNHYTALLGRGVYTNYVQAHVAPSGYTKLPYDYLVYLAKCSFLPKLNNELLQKNATYKQRITNLKNLVLIMFQEDGVVKPKESSLFGYYADGIPGPVLPLQQTRLYTEDWIGLRTLDETGRLKLISVPGVHLLISLSDTMRYVVPYLKDDASVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPI7</accession>
    <name>A0A068UPI7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030805001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPI7"/>
    <dbReference type="FunCoup" id="A0A068UPI7">
        <property type="interactions" value="2563"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPI7"/>
    <dbReference type="Gramene" id="CDP10177">
        <property type="protein sequence ID" value="CDP10177"/>
        <property type="gene ID" value="GSCOC_T00030805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPI7"/>
    <dbReference type="OMA" id="VWVHNRE"/>
    <dbReference type="OrthoDB" id="26384at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPI7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="2">
        <location>
            <begin position="567"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="761" mass="84681" checksum="FF31E62FBA766624" modified="2014-10-01" version="1">MFGKPSSSQSSGFSGSGAVSHVYVRYPPLRCKVSGSRNLFYDDGSKLLLTSTSDQVFSWKTAPFDPNVAPSCDSISEGPVLSVRYSLDCQLLAVQRSNHEVQIWNREGEKTFIYKCRSESEHILGFFWTDCPTCDIVFVKTSGLELFSYSSDSKSLTLVETKKTNVSWYIYTHESRLVLLAQGMQNKSFTGYQISSAGIIRLPRFEMVMAKHGANSRPVLSAEDVHIVTVYGRIYCLQFDRVAMLLHSYRFYRDAVIQQGSLPIYSNRIAVSAIDNVLLVHQVDAKVVIMYDLFADSRAPISAPLPLLLRLYPRAASLCSSSTSRNSDALETQILTDTESITYGDGWSFLVPDLICDVTNGLLWKINIDLEASCCGCLHSISSEVPFILDFLQRRKLEANKAKQLCLAIARAMILERRPVSVVARALDVLITSYSQSIKTRSNDKRTKAENTSNSGVSSANIVDDANNRIDASGKSVIDETVSSGLENESIERSFVLTSDSDDNLSAETQKINSLKLDSSSGKIDRGHSLRAESSSAAVHQPLSQSQVLRPGDTPLNAGAFDNLDSQVTSAVISPDDLYSSVFALVEEEMIGDASYLVAIIIEFLRRANLEKLKLHPNIYVLTVQLLARSERHAELGLFVINKILEPSLEVALQLLEPGRQNFQTRKLGLDMLRQLSLHHEYVLLLVQDGYYLEALRYTRKHKVTSVRPSLFLEAAYSSNDPRQLAAVLRFFCDFIPGFKNTSDHHTFNRVLAEMSTSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPQ9</accession>
    <name>A0A068UPQ9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00030844001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPQ9"/>
    <dbReference type="STRING" id="49390.A0A068UPQ9"/>
    <dbReference type="Gramene" id="CDP10199">
        <property type="protein sequence ID" value="CDP10199"/>
        <property type="gene ID" value="GSCOC_T00030844001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPQ9"/>
    <dbReference type="OMA" id="CRQDETH"/>
    <dbReference type="OrthoDB" id="1898954at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPQ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010471">
        <property type="entry name" value="DUF1068"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32254">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32254:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06364">
        <property type="entry name" value="DUF1068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="92" mass="10077" checksum="9D287B2D72F5B507" modified="2014-10-01" version="1">MSRRSGNCVRCCLVVFAVVSALCVSGPAIYWKFKKSLSLKTASLNSCSPCICDCAPPLSLLKIAPGMIFIGQSFKLWNNFSFFFGRHACMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URE8</accession>
    <name>A0A068URE8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00032974001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URE8"/>
    <dbReference type="FunCoup" id="A0A068URE8">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URE8"/>
    <dbReference type="Gramene" id="CDP11011">
        <property type="protein sequence ID" value="CDP11011"/>
        <property type="gene ID" value="GSCOC_T00032974001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URE8"/>
    <dbReference type="OMA" id="HIVPMEY"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URE8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000038">
        <property type="entry name" value="Probable inactive purple acid phosphatase 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011230">
        <property type="entry name" value="PAP14/16/28/29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030250">
        <property type="entry name" value="Ptase_At2g46880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658179" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="376" mass="41643" checksum="2741E6743BDA7D5D" modified="2014-10-01" version="1">MASFILVLLLTILCTVPVHASKQLRFNKNGEFRILQVADMHYANGKTTPCLDVLPQQVASCSDTNTTAFIRRLIFAEKPDLIVFTGDNIFGFDTTDPVKSMNAAFSPAISSNIPWAAVIGNHDQESTLSRKGVMKYVVGMKNTLSQLNPPEALGIDGFGNYNLEVHGIENSRLVNKSLLNLYFLDSGDYSKVPSIPGYDWIKPSQQLWFQQTSTKLQRAYMNEPEAQKSPAPGLVYFHIPLPEYASFDSSNFTGVKQEGISSASINSGFFATMVEAGDVKAVFTGHDHLNDFCGDLSGIHLCYAGGFGYHAYGKAGWSRRTRMVVASLEKTDEGVWGTLKSIKTWKRLDDEHLTAIDAQVLWSKMGARRKKHIGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URJ3</accession>
    <name>A0A068URJ3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033209001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URJ3"/>
    <dbReference type="STRING" id="49390.A0A068URJ3"/>
    <dbReference type="Gramene" id="CDP11150">
        <property type="protein sequence ID" value="CDP11150"/>
        <property type="gene ID" value="GSCOC_T00033209001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URJ3"/>
    <dbReference type="OMA" id="VQRITHE"/>
    <dbReference type="OrthoDB" id="672127at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URJ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF17">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="376" mass="43608" checksum="76D076D746190D94" modified="2014-10-01" version="1">MEEHKLQYLKSLLGQNIEVKKCVAAVEPLEAIARKCYAEPIDLSPQEFVKMMVFDGCFIIQLLRKFNGENVLDENDPIFKQDWILNSLQRDLMLLENQLPFFILCELYETLELPDKASELIRLALNFFSDLLPVQRITHENGNPREDISHLLDEKGNPLKDISHLLDLIHRDWSSKLEPQQDVNRSTGEYKSIRCSTQLTEAGIKLKKIDYKDIFGIQFDHGSLQIPTLVIEERTESFLRNLIAHEQYRGGDQINQINIVTDYVTFLGCLIKSEEDVTKLSHRGIICNLVGEDEVISEMVNKLIVCITGPSRNFYYAEIFRRLNIHCNRPGKRWMAKLRRNYCNSPWKIISIIVACLLLLLALLQTIFSILSWKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTI0</accession>
    <name>A0A068UTI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00034148001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTI0"/>
    <dbReference type="STRING" id="49390.A0A068UTI0"/>
    <dbReference type="Gramene" id="CDP11691">
        <property type="protein sequence ID" value="CDP11691"/>
        <property type="gene ID" value="GSCOC_T00034148001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTI0"/>
    <dbReference type="OrthoDB" id="420559at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTI0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655213" description="phosphopyruvate hydratase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="7">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="7">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="145" mass="16500" checksum="B221BA7B041610C5" modified="2014-10-01" version="1">MCFCCFDICLFIADLFLQSVIKKKYGQDATNVGDEGDIALISRRTRKVLNCLKQLLLKLVTLVKLHPSLGVYKFLLTQSLRLQQTNLVQQICCTEKGNNEERAFRLEVVIGMDVAASEFYGKDKTYDLNFKEENNDGSQKISGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTU8</accession>
    <name>A0A068UTU8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00033046001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTU8"/>
    <dbReference type="FunCoup" id="A0A068UTU8">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP11053">
        <property type="protein sequence ID" value="CDP11053"/>
        <property type="gene ID" value="GSCOC_T00033046001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTU8"/>
    <dbReference type="OMA" id="ICLAPEN"/>
    <dbReference type="PhylomeDB" id="A0A068UTU8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.430:FF:000003">
        <property type="entry name" value="Probable disease resistance protein At5g66910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1185">
        <property type="entry name" value="DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="183"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="438"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="588"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="111168" checksum="E14EA03D977FFCAB" modified="2014-10-01" version="1">MAESLSSTLSSAVQIIGKLVIEEVKFLQGVSERVRLLHDDLKGIQRFLRYADTKQTARDSIQQWVPEFRAVAYEAIDLVEDYVLRVSISSNGGCCTLKRIACMATEGYARHNLGVEIQSLRNRISNLTKNFGEYGHVMTRTEEGESSAPSRLQQLRRTRSSVADKDVVELPDDVQVLVKYLLNEVAEHKISVASIFGMGGIGKTTLARKVYHHGRLKDYFEGFAWVCVSQQWQPNDLLQGILLKLTPEQSNQIMTSKQDGLERLLQQHLQDNKCLIVLDDLWSTEAWDCLKDVIPVSEDGSKILLTTRNEDVAAYVGPNGYHHKLRCLTEEESWELLRKKSLWESNGAGCEDLGKMEELGKKMLNNCRGLPLAVVVLGGILRTKKTLKEWKEVHENIKSYLARGEKIGKEGEVPKILAYSYYDLPWQLKPCFLYLGKFREDSDIRAESLYQMWMGEGMIFENDRREQETMMDVAERYLKELAIRCMVEIKAYEEGKHAVTKLESCRLHDLMRDLCLDKAKEENLYKLVDRSPSQDSPPTTEAQFGLVLRLLPEDISQYKFPPKEQTKHLCSFLCDPLAGKGQLPIPGVRIMSQVKNLKMLRVLAMLSFNMASQSCYLKSPLGYVSKLIHLRCLRLRGQSINLPYSLGNLKYLETLDLSGSDNSCRIPNVLWKLERFRYLYLPNWWLGPQHKWGPQPKLQLSKQLEILESFDNRFCYPKDVCKLSNLRSFKANVYKNLEDLERIINHISNLDCLRISSLIIRSCNFGKTNSNNSNDSNGSLDVLSRVLFSRNIHELEIRNSLCKKLPDYQSQTVPHPAGLTQLSLSYSGIEEDPMATLEKLPKLRILELGPKSFLGQEMSCHSMGFPQLKDLVLFGLGNLMQWKVDEGAMPKLSGLRIEVCTTLEMIPDGLRCLTMLEEVSLAGMPEEFNNRVRIENGQQGEDYDKISHVPSVKIYRRVKGVIGYQVETVCPSNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV57</accession>
    <name>A0A068UV57_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00033809001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV57"/>
    <dbReference type="FunCoup" id="A0A068UV57">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UV57"/>
    <dbReference type="Gramene" id="CDP11518">
        <property type="protein sequence ID" value="CDP11518"/>
        <property type="gene ID" value="GSCOC_T00033809001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV57"/>
    <dbReference type="OMA" id="NSGCSVY"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV57"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="210" mass="24007" checksum="5DE509FA8C8F2EFD" modified="2014-10-01" version="1">MAAENPNCTVYVGNLDERVSDRVLYDILIQAGRVVDLYIPRDKETEKPKGFAFAQYETEEVADYAVKLFSGLVTLYKRTLKFAISGQDKPSMNLPTVSSSHKPRPHPVAYNEMGVSPNSMRLSTSCRFQDHQVNYSQVRVTPGVSVNQPNGYRSNYDNNDYEHSNGYRSHYDSNNYDYSRRVFGAALDNINRSRLGRYDTRDSTSYYASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVV7</accession>
    <name>A0A068UVV7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-deoxy-D-xylulose-5-phosphate reductoisomerase</fullName>
            <ecNumber evidence="5">1.1.1.267</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00035931001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:13719"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="5"/>
    <dbReference type="EMBL" id="HG739148">
        <property type="protein sequence ID" value="CDP12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVV7"/>
    <dbReference type="STRING" id="49390.A0A068UVV7"/>
    <dbReference type="Gramene" id="CDP12409">
        <property type="protein sequence ID" value="CDP12409"/>
        <property type="gene ID" value="GSCOC_T00035931001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVV7"/>
    <dbReference type="PhylomeDB" id="A0A068UVV7"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051484">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525:SF0">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal" evidence="13">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="235" mass="25902" checksum="934BDC150FB5F145" modified="2014-10-01" version="1">MKQTQRGRDTDKPEIIPGEEGVVEVARHPDAVSVVTGIVGCAGLKPTVAAIEAGKDICLANKETLIAGGPFVLPLAHKHQVKILPADSEHSAIFQCIQGLPEDTEQPFFFLLNSAKFTSKAFHINLGSHIFLLRIFVVSFLTDHSHAWNNEKTPPPVFSLSFCLCLKFKIDKVADALKHPNWNMGKKITVDSISIFSLQGLEVIEAHYLFGADYDNIEIVIHPQSIIHSMVETQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYM6</accession>
    <name>A0A068UYM6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038254001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <end position="83"/>
        </location>
    </feature>
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            <end position="83"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Lan T."/>
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                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00038651001"/>
    </dbReference>
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    <dbReference type="OMA" id="IMMASAC"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767:SF1">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="565" mass="60657" checksum="7108674E79248D0F" modified="2014-10-01" version="1">MIREDVHVMAEPDSSDGHGNYFTEVDPIPIPGPPGSFLPSPGHMDSEDIQGNSSLTSSRVQSSDDHQELVDHSSDSPVSATSTISNSNLARSDSKSSGKLSVGHPPFLDEMRSGCISAANGDPSLENSSAALKPSDAGIQRVSLDELKVSSSITEKGAFRFSSDQPCCCSRKEGFTQNVSLRSQESQLLRRRSTAAAIVPASGKELAGDIDRSLDSLRSEISSISGLSPRPETAVRSTMGHSLSRVSADSDVKFPNRDDSEPCCPSASNPVLRLMGKNLLVVKKEESISPQIKPCQLSSMISHTNPPVVALSGVSVGNARTDNQRIGHHMVSQSPFYTDQAESRKEVMQHPEMRWSDGLGSHDNMGILHLSPLASHAALSSRGAVRGGFMGTSMHHDYMAGCHLTIEKRQPLNRLDSSITCDVDKFVESPNFRWRSANTTANAIKEIIVIDDTPENEVNSTVATHSEGMIHGMGSCSGGKQIMMASACDSRHASSFHSYQQFEAAATFNESSVDASFWMPPPSPSGVDKSAVKWNWTPEGSNSLHASPLASAAQQRSKLYSSSNF</sequence>
</entry>
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    <accession>A0A068UZK1</accession>
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            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZK1"/>
    <dbReference type="Gramene" id="CDP13702">
        <property type="protein sequence ID" value="CDP13702"/>
        <property type="gene ID" value="GSCOC_T00038733001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZK1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7289" checksum="434505BFEFE2BD58" modified="2014-10-01" version="1">MSVCVQPYTEREYLGYTKILTCCVSCITLPFLLLLLLLFFSWGVFFWGAGGVGVNHKKDLRLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V012</accession>
    <name>A0A068V012_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039039001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V012"/>
    <dbReference type="FunCoup" id="A0A068V012">
        <property type="interactions" value="1460"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V012"/>
    <dbReference type="Gramene" id="CDP13902">
        <property type="protein sequence ID" value="CDP13902"/>
        <property type="gene ID" value="GSCOC_T00039039001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V012"/>
    <dbReference type="OMA" id="QVCRTVC"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V012"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="7">
        <location>
            <begin position="226"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="387" mass="42283" checksum="1ABFED7030D4A920" modified="2014-10-01" version="1">MASVNLKRHIVTALCRYYSIDSKVYLSDVDSNLKSLCSKITKSSSEGDALVDDKELTKWVAFVESLPIESSPSVKVLSELNEDLTKKSVLLANGLKPTAADIIVFAAVHPFVIGLPNSDRAKLPHFMRWVDYIQSKVDFGDCFERILIEKVQFEPPVVKNVKKVEPESTTKKVQETKEATSTRAETKVVKGVETKKDAAENQAAADNKKVTCKETVDKHTKDTEVSVSLLKIQIGLVRKVSKHPSADSLLVEDIDIGESKPRQVVSGLAKFISPEQLTNRHVVLITNVKPSKLRDILSEGLVLCASNQDHSVVEPLIAPEGAKIGESVTFAGFEGKPEDVLNPKKKQLEKITPHLLTDSSGIATFKGVPFMTSAGPCKSSIPNASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0S6</accession>
    <name>A0A068V0S6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038457001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0S6"/>
    <dbReference type="Gramene" id="CDP13498">
        <property type="protein sequence ID" value="CDP13498"/>
        <property type="gene ID" value="GSCOC_T00038457001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0S6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="48" mass="5472" checksum="8E879AE8975B8C37" modified="2014-10-01" version="1">MTNLKSHFRKKQTLNKAQVTTNKSSCQSLLLSPDPSNEQEERTLREGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0T7</accession>
    <name>A0A068V0T7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00038470001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; phylloquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0T7"/>
    <dbReference type="FunCoup" id="A0A068V0T7">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0T7"/>
    <dbReference type="Gramene" id="CDP13508">
        <property type="protein sequence ID" value="CDP13508"/>
        <property type="gene ID" value="GSCOC_T00038470001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0T7"/>
    <dbReference type="OMA" id="ITHKCCQ"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0T7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061522">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000048">
        <property type="entry name" value="14-dihydroxy-2-naphthoyl-CoA thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43240">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOYL-COA THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43240:SF5">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOYL-COA THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="8">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="165" mass="17443" checksum="278B4D8E3621523E" modified="2014-10-01" version="1">MASSSSSAVKTEAVDVTLAALGFVFEELSADKVSGHIQVSLKCCQPFKVLHGGVSALIAESLASIGAHMASGFKRVAGIHLSINHVKSAHLGDLVFAEATPVSLGKTVQVWEVKLWKIGTSRNTFSNSSEERSLTASSRVTLLCNLPVPENAKHAGDNLKKYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0Z4</accession>
    <name>A0A068V0Z4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00038562001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0Z4"/>
    <dbReference type="FunCoup" id="A0A068V0Z4">
        <property type="interactions" value="1863"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0Z4"/>
    <dbReference type="Gramene" id="CDP13568">
        <property type="protein sequence ID" value="CDP13568"/>
        <property type="gene ID" value="GSCOC_T00038562001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0Z4"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0Z4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP13568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="297" mass="31723" checksum="8139D204313B1BAC" modified="2014-10-01" version="1">MESPFKGDVLKGKVALLTGGASGIGFEISRQFGIHGASIAVMGRRKSVLDSAVSSLQSLGIPAVGFDGDVRKQEDAKRVVESTVKHFGKLDILVNAAAGNFLVSPEDLSPNGFRTVLDIDSVGTFTMCHEALKYLKKGGPGRRSCSGGLILNISATLHYTASWYQIHVSAAKAAVDSLTRSLALEWGTDYDIRVNGIAPGPISDTTGMSKLSPEEISSKAREYMPLYKLGEKWDIAMSALYLASDAGKYVNGTTIAVDGGLWLSRPRHLPKDAVKQLSRTVENRSRATPVGLPTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V134</accession>
    <name>A0A068V134_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance RPP13-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040735001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739166">
        <property type="protein sequence ID" value="CDP14376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V134"/>
    <dbReference type="FunCoup" id="A0A068V134">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP14376">
        <property type="protein sequence ID" value="CDP14376"/>
        <property type="gene ID" value="GSCOC_T00040735001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V134"/>
    <dbReference type="OMA" id="DQIIHLW"/>
    <dbReference type="OrthoDB" id="1896560at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V134"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF40">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="178"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="401"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="659"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1153" mass="132157" checksum="AAD064B6CF37FDB2" modified="2014-10-01" version="1">MAAALVGGSLLSAFLQVLFDRMARPEFLNLFRNRKADDDLLKKLKTSLLTVGAVLDDAENKEIRNQSVKKWLEELHDTFYQAEDLLDKINTEALRLKVESEYQSSTSRLCLERILPCTSSGNRFLKRIMPEIETIVVSLEGCIQQITPLGLQVVQSRIQSQQRFETPLVDETTIFGRDADKEKIIQMLLSEDANRDNITVVPIVGMGGLGKTTLARMVYKDLRVEVSFPTRAWVCVSEEYDATRITKELLRELNISFHDGEKLFSLQGKLQDGLTDKKFLLVLDDVWNSSYTDWDYLRTPFKGGLQGSKIIVTTRDLRVARTMELEEIGKKIVKKCGGLPLAVKTIAGILRSKTTSEEWEEISTSEEWTQIDNQNGPIPALRLSYIHLPSGLKRCFAYCAMFHRDYQFRKEEIIQLWQANDLLEYFEENKTIENKGEKCFNDLRMRLLFQQSTENLFTMHDLVNDLARFVFGKYCLRLEDHQEEDATISRVRNFSYHPSYYDTFHKFYLLRDSKNLRTFLPLRRGQFSDISCKLSNKFLEDTLPEFISLRVLSLPNYDNIVKLPDSYIRLKQLRFLDLSSTNIEKLQDWICTLYNLQTLLLSNCNKLKELPANLAKLINLCYLDISGIQLKKMAPQMGRLRKLQVLTTFIVGKDSDSTIEELGKLPMLRGRLLISGLENVSSGRDASMANIKGKKHLEELILKWNEDNYLQAVEDVLDNLQPDSRIKRLNITRYCGATFPNWLGSPTLSHLESLSLSGCEYCFFLPALGQLKSLQSLEIVQMSCILALTEEFYGDISATRPFPSLKKLRIEKMPEWEKWHIPQCDVFCSLEELCIIDCPKVIGEFPKQLSSLRRLEISGCDKLVIQNELCKLTSLEELEIQDCGSLLPFPVNYLPASLKSLECYRCDKFDLKSQSWQGRNLELLTLHHCQSLKVVLLGSFPMLKRLSINHCKGIEMLLGGLPAPNVTEISLSFCEKLKALPERMESLLPSLLHLNLFSCPELECFPKGGLPSSLQSLDISNCKKVMSCRREWGLEKLPSLINLSIGGTDEIELFPEKDWLLPSNLKTLLLMDHKNLKMLNYSGLRHLTSLQLLYIRNCTRLQSLPEEGLPAFLTNLEIRACPLLKPRLEWEKGQDWPKVAHISCVIVDLKLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2A5</accession>
    <name>A0A068V2A5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039201001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2A5"/>
    <dbReference type="FunCoup" id="A0A068V2A5">
        <property type="interactions" value="2530"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2A5"/>
    <dbReference type="Gramene" id="CDP14028">
        <property type="protein sequence ID" value="CDP14028"/>
        <property type="gene ID" value="GSCOC_T00039201001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2A5"/>
    <dbReference type="OMA" id="REYMERN"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2A5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="311" mass="35467" checksum="B08940DF3240ACE8" modified="2014-10-01" version="1">MHLRMPGGELDFLVEAKNSVKCMDNFRKLSPQVARYIYAPRVDWNLSTSRLLTMEYIDGAQVNDLKTIQRLGIQPRDVAKLVSHAFAEMMFKHGFVHCDPHAANVLVRPLPSGNGSIFGRKKPQLVLLDHGLYKDLDDSIRINYAALWKGLIFSDPKAIRENSVKLGAGEDLYALFAGILTMRPWNRVIDPAVDHLVVHGTDHSELQMYASQYFPQITELLRRLPRVILLMLKTNDCLRAVSNELMQGSSLESFLIIGRVSSEAVIESKLWQKRSILSRIDVWLERILLEARLFGMHVALWLLLLRRALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2P0</accession>
    <name>A0A068V2P0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042420001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739176">
        <property type="protein sequence ID" value="CDP14926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2P0"/>
    <dbReference type="FunCoup" id="A0A068V2P0">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2P0"/>
    <dbReference type="Gramene" id="CDP14926">
        <property type="protein sequence ID" value="CDP14926"/>
        <property type="gene ID" value="GSCOC_T00042420001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2P0"/>
    <dbReference type="OMA" id="KARMKFQ"/>
    <dbReference type="OrthoDB" id="1939205at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2P0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034604">
        <property type="entry name" value="SRRP53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31968">
        <property type="entry name" value="SERINE/ARGININE-RELATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31968:SF4">
        <property type="entry name" value="SERINE_ARGININE-RELATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="353" mass="40121" checksum="BA6A13DAB2EB5870" modified="2014-10-01" version="1">MEEEKAAALYDELTRKGGGAARFKQGLGFSSTSHREAVPSRGSGLPSFTSSSSSLLSTFVKASSPSKTGELEKQAQLESIQNKLKKTPHQPQNLIASTREVSRDRDRDSSHSSDRSRSGERERHSRRRSRSPSRNRERHSKRRSRSGSRDDYRMRRRGYRSRSRERESGRRRSSRSESPTQRKSSQNSTARKVEKERNNDGRVEYAETIEGYDKMTPAEKIKARMKFQLSEAAEKDEVKGTGSGWERFDFDRDAPLDDEEIEAVEDDAALVKHIGQSFRFATVEARRDKETRAAHDEAIFGVSSRPADPETAEQEEAGIVKKETHESTQITNLLSDQVLAMQQGSWRHCVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3T7</accession>
    <name>A0A068V3T7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00043006001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3T7"/>
    <dbReference type="FunCoup" id="A0A068V3T7">
        <property type="interactions" value="3694"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3T7"/>
    <dbReference type="Gramene" id="CDP15321">
        <property type="protein sequence ID" value="CDP15321"/>
        <property type="gene ID" value="GSCOC_T00043006001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3T7"/>
    <dbReference type="OMA" id="WSIMPLN"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3T7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000579">
        <property type="entry name" value="Os05g0230600 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655397" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="26"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="769"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP15321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="987" mass="110475" checksum="7F2E68E36B90DB2C" modified="2014-10-01" version="1">MAMAIRIRVLLLFLFFLSLSHLTFSLYQDQVGLMDWHQQYIGKVKHAVFHTQKAGRKRVVVSTEENVIASLDLRRGEIFWRHVLGSNDTVNELDIALGKYVITLSSGGKYLRAWNLPDGQMIWESFLPGSTASRSILSIPTNLKVGKDDLILAYGSGSLYAVSSIDGEVLWTKDLASEGIDVQQLIHRHGSNIIYALGFIGSSHFATFEINAKNGELLKHDKVRFTGGFCGDISFLKSDTAVALDSTRSSLVSVRFRDGEISIEQVHISDLLLDSSGVAAILPYKLIEMVAVKVKEFIIFVKLTNEGKFVVVDQIDHTAIISDSLSILEDQQAIALIQHGDNKIQLTVKLVSDWSNHLIKETIYMDCQRGLAQRIFLNNYVRTDRSSGFRALIVMEDHSLLLVQQGEIVWSREDGLASIVEVTTSELPLEKDSVSVATVEHSLLEWLKGHVLKLKGTLMLANPDDIAAIQKLRVQSSEKSKMTRDHNGFRKLIIVLTRAGKLFALHTGDGQIVWSVLLNSLRKSQTCEAPNVLTLHQWQVPHHHALDENPSILVLGRCGPNLDSPGVYSIVDAYTGKELNSVGPFHSIVQIIPLPHTDSREQRLHLLIDKDWHAHLYPRSPEALAIFQREVGNIYWYSVEADNGILRGHAAKENCILQLPDEYCFGTRNLWSIVFPSESERIIATATRKLNEAVHTQAKVVADQDVMYKYISKNLLFIATVAPQAAGDIGSVTPDESWLVVYLVDTITGRILHRMTHYGSQGPVHAVVSENWVVYHYFNLRAHRYEMSVIEIYDQSRADNKDVLKLVLGKHNLTSAISAYTRTEVVTKQQSYFFSHSVKAISTTSTAKGITSKQLLIGTVGDQVLALDKRFLDPRRTLNPTQAEKEEGIIPLTDSLPIIPQSYVTHALKVEGLRGIVTVPAKLESTTLVFAHGVDLFFTRLAPSKTYDSLTEDFSYALLLITIVALVVAIFVTWILSERKELQEKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3U4</accession>
    <name>A0A068V3U4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041077001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3U4"/>
    <dbReference type="Gramene" id="CDP14553">
        <property type="protein sequence ID" value="CDP14553"/>
        <property type="gene ID" value="GSCOC_T00041077001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3U4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655496" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="10256" checksum="78F7C6892DEAB05F" modified="2014-10-01" version="1">MRFSQNFSNLTLKLILFGCFPYECKSKLNGDIKRDKISIQDLIGINRINCEIQNNLLKESRVCKDEIQRKILNFIYIGISTQRKGDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6T8</accession>
    <name>A0A068V6T8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00018222001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739207">
        <property type="protein sequence ID" value="CDP16381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6T8"/>
    <dbReference type="FunCoup" id="A0A068V6T8">
        <property type="interactions" value="2165"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6T8"/>
    <dbReference type="Gramene" id="CDP16381">
        <property type="protein sequence ID" value="CDP16381"/>
        <property type="gene ID" value="GSCOC_T00018222001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6T8"/>
    <dbReference type="OMA" id="YAPRSHM"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6T8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="321"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP16381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="921" mass="102107" checksum="33AECE82B39805DD" modified="2014-10-01" version="1">MAGILKPPGAFTVTPHKVSICILIQVYAPPTQISVPFPFSSVSHHNRLGLFLFALSKSCDGIFEPKLDELIGQLKELGDFLNDWLIDHLTRRLSSLASPDDLFNFFNDLRGILGGSESHVMDDDQIMLDPSSNLGLFVRRCLLSFNLLPFEGVCHLLTNIGAYCKESFSSCPYELSHIEDCANEAESSMEYENMELESLVFDKVSKEFEAQKKANDSFAFHNHAPKAIIGFIEESDISSGSKVKEFDRLREGSSCIPSSSYSQRIIDPQVGSFLRTNWQIQGNLLDQADAIERHGSSFSLNAFESILKQLQKLAPELHRVHFLRYLNSLHHDDYPVALENLHRYFDYSAGTEGIDFGPPSSGCNSFGRYEVALLCLGMMHFHFGHPKQALEVLTEAVRVSQQHSDDACLAYTLAAICNLLSEVGISRMTGIIGSACSSVVNMRTSLSIQQQLFVLLRRSLKRAEGLKLKRLVASNHIAMAKFELTHVQRPLSYFGPKGPMKLRTCPINVCKELRLSSRLIHEFCDESSIMNTDGLLCTMWLKNLKKPIGSVIFSQENESRRNLDTFQFCSQPNSLPGSVVQLLGTSALVRATAWEIYGSASLARISTLAFAACFADSSSSADAALAYAKLIQHLAVFKGHKEAFAALKIAEEKFLCVSKSRVHLVKLQLLHERALHRGDLKFAQRICNEFGALASSVSGVDMELKTEASLRHARTLLAANQFNQAAAVTNSLFGMCYKYNMQVENATVLLLLAEIHKRSGNAALGIPYALASLSFCQSFNLDLLKASATLTLADLWLSLGSNHSKRALALLHSAFPMILGHGGLELSARAYITETKCYLADPSFSVSEDPEVVLEPLKRASEALELLEYHELAVEAFYLLAIVYDKLGYLEEREKAAALFKVHILALENPEEKEDSLSTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V733</accession>
    <name>A0A068V733_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00018059001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739204">
        <property type="protein sequence ID" value="CDP16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V733"/>
    <dbReference type="Gramene" id="CDP16284">
        <property type="protein sequence ID" value="CDP16284"/>
        <property type="gene ID" value="GSCOC_T00018059001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V733"/>
    <dbReference type="OMA" id="MYTSWIA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V733"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62768" checksum="140AA0054D0C0A39" modified="2014-10-01" version="1">MTKEALKFFAYGLQRFKASRKFPDRHDFNKSLHSLTRSNCGDLSLKLLVAFISKGYFPHVSAFNSVISYFCNLGFPGSAQKLINLMPKLGCLPDIVSYNSLIDGYLRNADVGDACFMMRKVCSGLMNVRPDLVTFNAMFNGFCKVGKVEGLLVYMSLMWKVCVPNVVTYGILVDMYCKMNNVNMAYRVFKDMKSSGVFPNLQIFTSLIDGYCKAGELEVALGLYLDMHRNSVFPNVVTYSALIDGFCKRGMLEKAAYLFSRMLEDGVEPNIVVYTSMIDGEFKKKNIDNALKYLSRMHDQGIRHDVTAYGAIVSGLCNMNRLDSAVEVKKAMMDYGVAPDGVIFATLMHAYFEAGNVEAAMNEYEESLARGFQPDVVALTSLIDGLCKNGRLYEAKLHFSKENADEISYNVLIHGMCKEGELSQVEMVYREMTDAGFVPNKYFYTTWIAGLCKQGNLVEAFRLQKQMIKEGIPPNLFAYSSLIFGLTNKGFMIEAKQVFDDMLKKGISPNHVVYDILIRGYAKEGNQPAISCLIDEMRMRGLLSDDGCNQKYMLHDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V845</accession>
    <name>A0A068V845_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00019160001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V845"/>
    <dbReference type="FunCoup" id="A0A068V845">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V845"/>
    <dbReference type="MEROPS" id="M48.021"/>
    <dbReference type="Gramene" id="CDP16692">
        <property type="protein sequence ID" value="CDP16692"/>
        <property type="gene ID" value="GSCOC_T00019160001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V845"/>
    <dbReference type="OMA" id="PNAMCIG"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V845"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900055">
        <property type="term" value="P:regulation of leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07325">
        <property type="entry name" value="M48_Ste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000007">
        <property type="entry name" value="Peptidase M48 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="130"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="347" mass="38253" checksum="8F72F9F2EB0D01C7" modified="2014-10-01" version="1">MAYIPLSSSLNLPAAKVSPLARSFRGTTASTVGSKENLAVSFSLSSLRPRPPKIHRIFRLTVSGAASVVFRNLDADDFRHPLDRQNTLLLRAIPGLNDIGKALLGTVTEQVMLLENIGTSVLVTENQLPELHSLMIQASHILNIESPDLYVRQSPIPNAYTLAISGKKPFIVVHTSLVELLTRRELQAVLAHELGHLKCDHGVWLTFANILTLGAYSLPGLGGLIAQRLEEQLLRWLRAAELTCDRAALLVAQDPKVVISVLMKLAGGCPSLADQLNVDAFLEQARSYDKASSSPVGWYIRNAQTRQLSHPLPVLRAREIDEWSRSQEYKYLLTRAVVVNPMQRVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9L8</accession>
    <name>A0A068V9L8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00000666001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739232">
        <property type="protein sequence ID" value="CDP17197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9L8"/>
    <dbReference type="FunCoup" id="A0A068V9L8">
        <property type="interactions" value="1220"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9L8"/>
    <dbReference type="Gramene" id="CDP17197">
        <property type="protein sequence ID" value="CDP17197"/>
        <property type="gene ID" value="GSCOC_T00000666001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9L8"/>
    <dbReference type="OMA" id="FFKKEQR"/>
    <dbReference type="OrthoDB" id="1932324at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9L8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000005">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF6">
        <property type="entry name" value="OS01G0256600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP17197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15374" checksum="A7287C6C1ED8AB7E" modified="2014-10-01" version="1">MKKNTHFRINFQPFDEFIKMVIPPAVRPERVTNFLKPYVLKMHFTNKFVSAQVIHTPTATVASSASSQEQALRLSMEKARESTRDVAAAGKIGKILGERLLLKGIPAVSIFLKREQKYHGKVKAVIDSVREAGVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA00</accession>
    <name>A0A068VA00_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00009684001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739239">
        <property type="protein sequence ID" value="CDP17349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA00"/>
    <dbReference type="STRING" id="49390.A0A068VA00"/>
    <dbReference type="Gramene" id="CDP17349">
        <property type="protein sequence ID" value="CDP17349"/>
        <property type="gene ID" value="GSCOC_T00009684001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA00"/>
    <dbReference type="OrthoDB" id="1848451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA00"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055290">
        <property type="entry name" value="At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006527">
        <property type="entry name" value="F-box-assoc_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546:SF130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546">
        <property type="entry name" value="F-BOX PROTEIN INTERACTION DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07734">
        <property type="entry name" value="FBA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="382" mass="43576" checksum="741656AD34EB11BF" modified="2014-10-01" version="1">MAPCRKKIYRGHSRRTTKMVCASAEAIESCDEILIQILKHLPAKSLFRFKLVSKRWSSLISDPFLKSIWKPRVSGLFIQISTKKTCKTKHEYIKVEAKLPNSLQDNLSFLNSDGNSICGTEILSSCNGLFLILCKKGSKLFYNHRYYICNPTTKKYVAVPCPERRSAWKEVNMFLAYDPSESIAYKLVAISSIRRSQIFVNMYSSESKSWKGLEGVALGDVCFNLGVYFDGSILWPALRSEESQCFNVSSEVFQRFAMPPLQKSNQQRKLKHFGKTNEGHLCLILGSSSDANMLFVHQMKRGQFNWSVKYHVDLTSLASAFHVLHIASKEDEVSSMILLVKGRAMSHEFKDKTYKELQKIALPDQKCLVVHQLIENPFCLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAA9</accession>
    <name>A0A068VAA9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00000584001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739259">
        <property type="protein sequence ID" value="CDP17710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAA9"/>
    <dbReference type="Gramene" id="CDP17710">
        <property type="protein sequence ID" value="CDP17710"/>
        <property type="gene ID" value="GSCOC_T00000584001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAA9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="7161" checksum="6237E85EFAF762F7" modified="2014-10-01" version="1">MLSKFDLTQVVEVFVRVTGGKVEAASFSHSQNRPICPLPKENWRRHRKRNRQGLEGPPRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAT7</accession>
    <name>A0A068VAT7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00001211001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739278">
        <property type="protein sequence ID" value="CDP17965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAT7"/>
    <dbReference type="FunCoup" id="A0A068VAT7">
        <property type="interactions" value="1393"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAT7"/>
    <dbReference type="Gramene" id="CDP17965">
        <property type="protein sequence ID" value="CDP17965"/>
        <property type="gene ID" value="GSCOC_T00001211001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAT7"/>
    <dbReference type="OrthoDB" id="1621991at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37764">
        <property type="entry name" value="KETOSE/ALDOSE ISOMERASE, PUTATIVE (MOG1/PSBP/DUF1795-LIKE PHOTOSYSTEM II REACTION CENTER PSBP FAMILY PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37764:SF1">
        <property type="entry name" value="KETOSE_ALDOSE ISOMERASE, PUTATIVE (MOG1_PSBP_DUF1795-LIKE PHOTOSYSTEM II REACTION CENTER PSBP FAMILY PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20097" checksum="93BEE6DCF6FE58F1" modified="2014-10-01" version="1">MSTFLLSLFPKPPQNPISRKPISPLKHPSILISRRLGIIFTTTSLSSVLSLVLQCPQIPPSSAAEASSTSFLSGIANTKSWFQFYGDGFAIRVPPQFEDILEPEDYNAGLSLYGDKAKPKTFAARFASPDGSEVLTVVIRPSNQLKITFLEVGKWNCSAYSELISVTPETDLLLSLLLLYCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB41</accession>
    <name>A0A068VB41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00003885001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB41"/>
    <dbReference type="FunCoup" id="A0A068VB41">
        <property type="interactions" value="1516"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB41"/>
    <dbReference type="Gramene" id="CDP17769">
        <property type="protein sequence ID" value="CDP17769"/>
        <property type="gene ID" value="GSCOC_T00003885001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB41"/>
    <dbReference type="OMA" id="WYRHWVR"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000100">
        <property type="entry name" value="Glutathione S-transferase Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="266" mass="30081" checksum="90DA6E9AA6AA9061" modified="2014-10-01" version="1">MTIAYKRNFPTLTINNVSTYYLLAAEAMSIHPFPLCFIMATGGHGAREEAEPKKLKLYSYWLSSCSCRVRIGLDLKGLEYEYVAVNFPEGEQQTPEFLKLNPMGYVPVLVDGDIVLADSFAILLYLDEKFPQHPLLPKDSVRRAINFQAANVISSSIQPRQLMLQHMREKLGPQEAIACAQDDLRTGFAALEKLLKDYAGRYATGNEVFLVDLFLAPQIHAAITRFKVEMDEFPLLSRLFEAYMELPAFQDNMPGKQPDTPAEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC64</accession>
    <name>A0A068VC64_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00013666001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739233">
        <property type="protein sequence ID" value="CDP17253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC64"/>
    <dbReference type="FunCoup" id="A0A068VC64">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VC64"/>
    <dbReference type="Gramene" id="CDP17253">
        <property type="protein sequence ID" value="CDP17253"/>
        <property type="gene ID" value="GSCOC_T00013666001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC64"/>
    <dbReference type="OMA" id="NAYYIRE"/>
    <dbReference type="OrthoDB" id="1922833at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC64"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000002">
        <property type="entry name" value="Nac domain-containing protein 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF211">
        <property type="entry name" value="OS04G0691300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="318" mass="36734" checksum="9070127F18964062" modified="2014-10-01" version="1">MEMESRVPPGFRFHPTEEELVGYYLNRKVNSLKIDLDVIVDIDLYRMEPWDIQDRCKLGYEEQNEWYFFSHKDRKYPTGTRTNRATAAGFWKATGRDKAVISKEKIIGMRKTLVFYKGRAPNGRKTDWIMHEYRLQTSEQGPSQAKGWVVCRAFKKPCPSHKQGFEAWSNAYYIRENGKYQPPSFPDKSITSMHAVNPISIHGVDFQQVPLRADHHELISNHAARFDNQLIEIPQLDSPSISTSLATKDQVFESGSLVNEDGEDVKSNIYCQQYNDWKVFDKLLVQQVIDPSASYACQNQPVLLPRDDELLLGCFTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCG6</accession>
    <name>A0A068VCG6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00011828001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739303">
        <property type="protein sequence ID" value="CDP18257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCG6"/>
    <dbReference type="FunCoup" id="A0A068VCG6">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCG6"/>
    <dbReference type="Gramene" id="CDP18257">
        <property type="protein sequence ID" value="CDP18257"/>
        <property type="gene ID" value="GSCOC_T00011828001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCG6"/>
    <dbReference type="OMA" id="ADACHSS"/>
    <dbReference type="OrthoDB" id="1921534at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCG6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11393">
        <property type="entry name" value="bHLH_AtbHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045239">
        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF49">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH52-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="301" mass="33221" checksum="66A939601F927D1E" modified="2014-10-01" version="1">MALSCYSNWGELEQHHDLEMTLQFAQPPAAELSPELLGFNHMNFAFSDPYLDPILESQDLVYSDNYTSLLPHFSSPSDENPNSLYSLVPEVFPELEYQPCHSAKRQKIFEGCYNNSEVLPSSFGSRFIPNPPLIQELSPPEILSPFSGSLASEPPVFCSGGTGEMTVKKASNGGTLSSQSIAARQRRRKITEKTQELGKLIPGGQKMNTAEMFQAASKYIKFLQAQVGILETLASVQENGKSLQNEELNPLLGSSLIQEKLYSMEMCLAPQKFVQSLAEDNGIELNTRALNDCKELIGIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD75</accession>
    <name>A0A068VD75_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00005148001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739253">
        <property type="protein sequence ID" value="CDP17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD75"/>
    <dbReference type="STRING" id="49390.A0A068VD75"/>
    <dbReference type="Gramene" id="CDP17633">
        <property type="protein sequence ID" value="CDP17633"/>
        <property type="gene ID" value="GSCOC_T00005148001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD75"/>
    <dbReference type="OMA" id="HESTGPI"/>
    <dbReference type="PhylomeDB" id="A0A068VD75"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46662">
        <property type="entry name" value="DI-GLUCOSE BINDING PROTEIN WITH LEUCINE-RICH REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46662:SF104">
        <property type="entry name" value="GPI-ANCHORED ADHESIN-LIKE PROTEIN PGA55-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36020" checksum="D6AF41F324BDC8A7" modified="2014-10-01" version="1">MRLVFVHESTGPIPNEIGNLLKLEILDLRWNSLNGSLPVEIFNMSTLRMLYLAGNHLSGVLPSNMCHGPHNLEYIYLGGNNFSGAIPASISNCSKLIEIYLHSNKFSSPIPNSIGNLRHLEVLDLSANNLTSELGLFTSLTGCISLREISVGDNPGLRGNIPDSIGNLSNLAHLYLRDNSLCGSIPTAIWDLQMLHDLDLSNISLTGPLPRGLCGLQSLEGLLLSQNQISGSIPGCFNNLTSLWYLDIAFNRLTSTLPLWDLKGLVYVNLTSNLLRGPLAPEMGELKDLAELDLSNNQFSGKIPSTIWSLESLDHLSLANNSLQGSIPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDP8</accession>
    <name>A0A068VDP8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00001009001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP18970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDP8"/>
    <dbReference type="STRING" id="49390.A0A068VDP8"/>
    <dbReference type="Gramene" id="CDP18970">
        <property type="protein sequence ID" value="CDP18970"/>
        <property type="gene ID" value="GSCOC_T00001009001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDP8"/>
    <dbReference type="OMA" id="FSWWWDS"/>
    <dbReference type="OrthoDB" id="1924020at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011684">
        <property type="entry name" value="NAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31631">
        <property type="entry name" value="PROTEIN NETWORKED 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31631:SF0">
        <property type="entry name" value="PROTEIN NETWORKED 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07765">
        <property type="entry name" value="KIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51774">
        <property type="entry name" value="NAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB" evidence="4">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP18970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="236" mass="27375" checksum="FB88F90B06CDE850" modified="2014-10-01" version="1">MEKEGGDRAASDDSRWLEKNGSSYRNRSHHHQSQWLQSTLAELERKIQKILELVEDDGDTFAQRAEMYYKKRPELIGVVEDLRKSYISLANKYDILRSESLCASSNSFRLQSSLPPSAVLALQLHEAEAVCKINGGFDDSRRDRDGDMWNKMRQSVSELIDDNLSQQAELIRRNNEKTESIRRLGPRINQLQNENKRLKELLAQQQQQHKNTADRDCKHNRSHLSKLKGLVFRKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDQ0</accession>
    <name>A0A068VDQ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00013414001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739381">
        <property type="protein sequence ID" value="CDP18871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDQ0"/>
    <dbReference type="STRING" id="49390.A0A068VDQ0"/>
    <dbReference type="Gramene" id="CDP18871">
        <property type="protein sequence ID" value="CDP18871"/>
        <property type="gene ID" value="GSCOC_T00013414001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDQ0"/>
    <dbReference type="OMA" id="HMANAIN"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDQ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="130" mass="14602" checksum="4D8CFB05ABF01EEF" modified="2014-10-01" version="1">MESEDSNPAALGLYMAEALNKYRILYCHMVEPRMKTLGKKFECADTLLPMRKAFKGTFIVAGGYGREDGSEAVAKDNADLVAYGRLFLANPDLAKRFELNAPLNKYNRTTFYIPDPVVGYTDYPFLETIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDS9</accession>
    <name>A0A068VDS9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00001051001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP19000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDS9"/>
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        <property type="interactions" value="2309"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDS9"/>
    <dbReference type="Gramene" id="CDP19000">
        <property type="protein sequence ID" value="CDP19000"/>
        <property type="gene ID" value="GSCOC_T00001051001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDS9"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDS9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000347">
        <property type="term" value="C:THO complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:3'-5' DNA helicase activity"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:single-stranded DNA helicase activity"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17855">
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    <dbReference type="Pfam" id="PF14551">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="533"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="140"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP19000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="969" mass="109196" checksum="174A83CCD43C042B" modified="2014-10-01" version="1">MSREGESGGGSGGMPGRSDESSSRSDQGNINPTPSTPESPTSAGFNTDQLPPNTSQNYSEEEDDDEASVDPEIIRDEEENEAEEEEEGEDLFNDNYLDDYRRMNEQDQYESLGLDDSMEDERDLDQIMADRRAAEIELAARDTRFRASSQQRKLPQLLHDQDTDDDNYRPSKRTRADFRPPTAPRSFEDTDAMQSSPGRSQPANSRGDVPMTDPTDDDPFEDDDNEDGEFEMYRVQGTLREWVTRDEVRRFIAKKFKEFLLTYVNPKSDSGDFEYLRQINEMVSVNKCSLEIDYKQFIYIHPNIAIWLADAPHSVLEVMEEVANKVVFDLHPNYKQIHQKIYVRITNLPVYDQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKYDCNKCGAILGPFFQNSYSEVKVGSCPECQSKGPFTVNIEQTIYRNYQKLTLQESPGIVPAGRLPRCKEVILLNDLIDCARPGEEIEVTGIYTNNFDLSLNTKNGFPVFATVIEANYVTKKQDLFSAYKLTQEDKEEIEKLAKDPRIGERIIKSIAPSIYGHEDIKTAIALAMFGGQEKNVEGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGQRAVYTTGKGASAVGLTAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSVVAAANPIGGRYDSSRTFSQNVELTDPIISRFDILCVVKDVVDPVTDEMLAKFVVDSHFKSQPKGATLDDRSVLNSNDDAQASVLPADPEIISQDLLKKYITYAKLNVFPRLHDADLDKLTQVYAELRRESSHGQGVPIAVRHIESMIRMSEAHARMHLRQHVTQEDVDMAIRVLLDSFISTQKFGVQKALQKSFKKYMTFKKDFNAIILHLLRGLVKGALDLELSSGSTANLPHIDVKVEELQTKALEYGIADLKPFFSSAEFSLANFELDERRCVIRHRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDT1</accession>
    <name>A0A068VDT1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00002646001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739362">
        <property type="protein sequence ID" value="CDP18717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDT1"/>
    <dbReference type="FunCoup" id="A0A068VDT1">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDT1"/>
    <dbReference type="Gramene" id="CDP18717">
        <property type="protein sequence ID" value="CDP18717"/>
        <property type="gene ID" value="GSCOC_T00002646001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDT1"/>
    <dbReference type="OMA" id="VHYVVTQ"/>
    <dbReference type="OrthoDB" id="442633at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDT1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000022">
        <property type="entry name" value="Taxadiene 5-alpha hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF221">
        <property type="entry name" value="TAXADIENE 5-ALPHA HYDROXYLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54266" checksum="C1EF016C1E72539B" modified="2014-10-01" version="1">MAFDLSFVLPLFSAVVALALAVVFYNFTSSNNKSKKNLPPGELGLPWIGETLQFHKAQRNNRLYEEFVQPRIQKNGKTFKTRLMGSPTVVVNGAEANKFFLSNEFKLVVSSWPTSSVQLMGSDSIMEKQGDAHRCVRGIIATSLSCSGLEAMVPMICNTVQSHLDENWRGKDVISLYRLTKTLTFTIVLECMLGIEVQPEMLGMFEKVLEGVFSLPFRFPGTAFSRAKNARIEVEKMLLNIVRKKREEIAFQQVVEGGGMLLFRLVKAMIQGEMSEKEVVDNMVLLVFAAHDTTSFAITMTFRMLAHHPNCYSQLLQEHLDIKDNRRPGETLTLEDIKKMNCTWQVARESMRMFPPIFGSFRKAIVDIEYDGFTIPKGWKVLWTAYGTHYESEYFEDPLRFNPSRFEVPVQPYAYLPFGGGPRQCAGYQLAKLNILILIHFVVTQYEWSLVNPQEPIAVDPLPFPSQGMPIRISPKLS</sequence>
</entry>
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    <accession>A0A068VE66</accession>
    <name>A0A068VE66_COFCA</name>
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        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_292</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">GSCOC_T00004108001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
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                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="192" mass="21568" checksum="8DCC26A322A805BD" modified="2014-10-01" version="1">MCSKKKRCRHSYDLNCSALQFNSSGNGFCSNSWDRLQCLSLWIGQLFLPTAKEILSIDFEDFSANETWILDDEPSQLTSAELESFRNDIATFAISRQSDETLNLDDLDTEDEDETNNEENVERNDLNAGCDVNELGGTEFGRNTIGYAQTAPSGQMDLSQWERFYLMGTNANLGQKSEIGTSGHKDIISYLT</sequence>
</entry>
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    <accession>A0A068VGF7</accession>
    <name>A0A068VGF7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">GSCOC_T00002512001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
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                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
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    <dbReference type="EMBL" id="HG739870">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGF7"/>
    <dbReference type="Gramene" id="CDP19920">
        <property type="protein sequence ID" value="CDP19920"/>
        <property type="gene ID" value="GSCOC_T00002512001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGF7"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
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    </dbReference>
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        <property type="term" value="P:lateral root development"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ORC3"/>
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        <property type="entry name" value="ORC3_N"/>
    </dbReference>
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        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="598"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="729" mass="82224" checksum="0D15A617EA81C259" modified="2014-10-01" version="1">MGTSNPVVVDENSLQPYFVLHKASQPPRKTSGKTKRRIDLSPLDPHKSDNGSVEDLDCFGMCLQTFHFFWSKIEVVIKDVMREINGDVFDKIGCWIRESFDAMSSCKVSDLSQATNSYPLLLPASHLALSKQLFTGLVCTKNMEFVDDSPTFTELAQHLKSRGCHVANLSSLDFYEKNGTSNCLRNLLRQFLMGSTDAADISSLASWYHEQDRYKNPIIVIIEGIERCRESVLSDFITLLSEWTVKLPIILIMGVTTIVDALRDILPSSTLQYLSPSKFVLGSPTERMDAVIESVLVKYGTCFCLGHEVATFLRNYFLREDGTLTSFIRAFKMACVQHFILYPSGLAISGLLENKYSHDLSYGTIASLQGSIVKQAFGLPSQLRNNQVEPDGDIFHDLTEIQRHWHLWSSLVMCIYEAAKYQKTTLLDLYCEVLDPQLYKAEASGDQVASRYSGSLCSKSHCLLGKHPSLEMCGSICQAARGLRDLPAKELWQLLMKWSELTNGTSEVHEKIKELQSLARSEDRMHLSMQQMDMSNIHTIRGNVISGKDMAKLGEQAARLAGCMVWEYMQPIECIPLHEVICFKNVDKLQSALIGDPRTRIQIDLLESQKFLKCSCCRENACISLPSIHDTSIIYSLAQEHGDLINIHDWFQSFKVTISKSGMRTKSRLKQSQSPSPKKRKPSNEPQKISEASIQARFCRAVCELQIAGLIRMPSKRRQDYVQRVAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH85</accession>
    <name>A0A068VH85_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00007992001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740040">
        <property type="protein sequence ID" value="CDP20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH85"/>
    <dbReference type="STRING" id="49390.A0A068VH85"/>
    <dbReference type="Gramene" id="CDP20170">
        <property type="protein sequence ID" value="CDP20170"/>
        <property type="gene ID" value="GSCOC_T00007992001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH85"/>
    <dbReference type="OMA" id="LEVCKYV"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH85"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF70">
        <property type="entry name" value="NMRA-LIKE DOMAIN, NAD(P)-BINDING DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="97" mass="10330" checksum="ED54A0D854D4DEA7" modified="2014-10-01" version="1">MDVKSKILIIGGTGNIGKYLVEASAKAGHPTFALVRESTISDPKRAAIIESFKSLGVMFLHGDLHNHQQLVNAIKQVDIVVSAVGGDLVAHQVKIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHN3</accession>
    <name>A0A068VHN3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003317001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740062">
        <property type="protein sequence ID" value="CDP20191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHN3"/>
    <dbReference type="FunCoup" id="A0A068VHN3">
        <property type="interactions" value="1116"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VHN3"/>
    <dbReference type="Gramene" id="CDP20191">
        <property type="protein sequence ID" value="CDP20191"/>
        <property type="gene ID" value="GSCOC_T00003317001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHN3"/>
    <dbReference type="OMA" id="VPWVPSH"/>
    <dbReference type="OrthoDB" id="1937743at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35510">
        <property type="entry name" value="DBH-LIKE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35510:SF1">
        <property type="entry name" value="DBH-LIKE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="241" mass="26749" checksum="D862A51901911F96" modified="2014-10-01" version="1">MPEGFNSVLKMKRKDLDQVNEEFSDFSLTSPARKIRRLDAELAPITEEEPEIPLVFERPENEGSFGGGNGRVGGGGVVIEELPNGVENEERAIVVFNPVNSPLLQSPSNYSISVSPPLISGLKNQLPWSNYSSQWRALESEDRTDDNKSGRQNECLAVVPWVPPPHLYSTSGDEAVPQIDVSDMMEADDAEVSTMDVEDNTVGSEQKVGMNVNEGLRQWQQQHCMIPQPPQNISTPIVWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI76</accession>
    <name>A0A068VI76_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00002595001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739542">
        <property type="protein sequence ID" value="CDP19373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI76"/>
    <dbReference type="STRING" id="49390.A0A068VI76"/>
    <dbReference type="Gramene" id="CDP19373">
        <property type="protein sequence ID" value="CDP19373"/>
        <property type="gene ID" value="GSCOC_T00002595001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI76"/>
    <dbReference type="PhylomeDB" id="A0A068VI76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="74" mass="8523" checksum="64F1DCF92E6E1F1C" modified="2014-10-01" version="1">MANNSAAQMVFGITAEHNPSLERHVFPNPVDASGYMVMLWYKNGSLTREDIRNRCAEKSWEVFNKLLQQTPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIJ1</accession>
    <name>A0A068VIJ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lipoxygenase</fullName>
            <ecNumber evidence="15">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00013093001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Lipid metabolism; oxylipin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="15"/>
    <dbReference type="EMBL" id="HG740519">
        <property type="protein sequence ID" value="CDP20620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIJ1"/>
    <dbReference type="STRING" id="49390.A0A068VIJ1"/>
    <dbReference type="Gramene" id="CDP20620">
        <property type="protein sequence ID" value="CDP20620"/>
        <property type="gene ID" value="GSCOC_T00013093001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIJ1"/>
    <dbReference type="OMA" id="DIKDASW"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIJ1"/>
    <dbReference type="UniPathway" id="UPA00382"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.60:FF:000002">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.375.10:FF:000001">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.375.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.372.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020833">
        <property type="entry name" value="LipOase_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001246">
        <property type="entry name" value="LipOase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027433">
        <property type="entry name" value="Lipoxygenase_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00468">
        <property type="entry name" value="PLTLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00711">
        <property type="entry name" value="LIPOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 15" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="17">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="18">
        <location>
            <begin position="105"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP20620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="772" mass="88114" checksum="B171C66F33F6B7E0" modified="2014-10-01" version="1">MFSCFFAGNALKGKLGTPAFLEKWITTLTSLTAGESAFNVTFDWDEEVGAPGAFIIKNLHHNEFYLKTVTLEDVPGHERIHFVCNSWVYPADKYKTDRIFFSNQAYLPHNTPEPLKFYREAELVNLRGDGTGERKEWDRIYDYAYYNDLGDPDKNDPSYVRPVLGGSVEYPYPRRGRTGRPPTKTDPKSESRLPLLMSLNIYVPRDERFGHLKMSDFLAYGLKSISQLLSSELEAQFDSTPSEFDSFEDMQKIYEGGIKLPKSLTENISLEILKQVLPTDGEGLLKYPLPKIIEGDRSAWRTDEEFAREMLAGLNPVIISALKEFPPVSKIDPNVYGNHTSTITREHIENKLDGLTVEEAIKTNRLFILNHHDTIMPYLRRINATPTKTYASRTLLFLHENGTLKPVAIELSLPHPDGDQFGAISEVYTPAEQGVENAIWQLAKAYVAVNDSGIHQLITHWLRTHAVIEPIVIATNRQLSVLHPIYKLLHPHFRDTMNINAIARQILTNAKGVVESTLFPSRKMAVKDSTSPFGLRLLIEDYPYAVDGLKIWSAIKTWVTDYCSFYYKSDQMIQEDIELQSWWKEVREKGHADKKDEPWWPRMKTITELIDSCTIIIWLSSALHAATNFGQWPYAGYQPNRPTTSRRFMPEPGTPEYEELKSNPDKAFLKTITPQFQTLLGLSTIEILSRHTTDEVYLGQRENPQWTKDTEPLEAFKRFGQTLSEIEDQILQMNGDPKWRNRVGPVNIPYTLLFPTSDSGITGRGIPNSIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIJ6</accession>
    <name>A0A068VIJ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_520</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00006746001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739604">
        <property type="protein sequence ID" value="CDP19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIJ6"/>
    <dbReference type="STRING" id="49390.A0A068VIJ6"/>
    <dbReference type="Gramene" id="CDP19498">
        <property type="protein sequence ID" value="CDP19498"/>
        <property type="gene ID" value="GSCOC_T00006746001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIJ6"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIJ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="263" mass="28020" checksum="C3E30EDCC8E968AB" modified="2014-10-01" version="1" fragment="single">PLPPGPPSVRSFLAAPNRPARSLLLSSAAYSSISSSLSSPSSGSDDDSLCLWLYDTFLSADSELCLVVLCYIPLLSSFYLSRIHSSSSTSAISPNPNLAGFEAVLLVLYSSEVKAHSGIPVLISIPDLSQPSLYHSSRNPPSNKSNPINNNPSSRPLVGVLSPPLEPQMAVKSTKRASIVGIALDCYYKQISQMPSWSKLDFCKFSADWASQDCPCKSDFDDFTTQKPDNFTENSHGLSGGENSAAMGVITAGIEELSCSSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJI0</accession>
    <name>A0A068VJI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00007866001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740688">
        <property type="protein sequence ID" value="CDP20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJI0"/>
    <dbReference type="STRING" id="49390.A0A068VJI0"/>
    <dbReference type="Gramene" id="CDP20709">
        <property type="protein sequence ID" value="CDP20709"/>
        <property type="gene ID" value="GSCOC_T00007866001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJI0"/>
    <dbReference type="OMA" id="DHEFRSG"/>
    <dbReference type="PhylomeDB" id="A0A068VJI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008190208" description="Dirigent protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="19650" checksum="6AD12F4155E2D826" modified="2014-10-01" version="1">MAKSLAIASLQILSLLLLASLGQSKTVFTNLTVYDHEFRSGDGQSVFPVAGLPNATWGFNQFGTVFVVDNTLTQSVSFKSALVGRSQGIAAVASLDNTNAELVITFLFTNGKYSGSTVEMKGIFIQSMGVNELAILGGTKQFRYATGYATFEVVSQVGDHLTLKANLYIRQDIPDDYPGIALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKE3</accession>
    <name>A0A068VKE3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00010702001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741732">
        <property type="protein sequence ID" value="CDP21166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKE3"/>
    <dbReference type="STRING" id="49390.A0A068VKE3"/>
    <dbReference type="Gramene" id="CDP21166">
        <property type="protein sequence ID" value="CDP21166"/>
        <property type="gene ID" value="GSCOC_T00010702001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKE3"/>
    <dbReference type="PhylomeDB" id="A0A068VKE3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="86" mass="9920" checksum="D8AFC487F8F9FACD" modified="2014-10-01" version="1">MGIADVIVVLVGSGTTLREKFFKKFNGFFILESQVTPLVFFFSNNDNIYMLGMTHEMLERLEANLMANGFLMFMMRWFALISVFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKU0</accession>
    <name>A0A068VKU0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_4164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00006081001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743248">
        <property type="protein sequence ID" value="CDP21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKU0"/>
    <dbReference type="STRING" id="49390.A0A068VKU0"/>
    <dbReference type="Gramene" id="CDP21445">
        <property type="protein sequence ID" value="CDP21445"/>
        <property type="gene ID" value="GSCOC_T00006081001"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
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    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338:SF32">
        <property type="entry name" value="OS06G0287500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="342"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="717" mass="81012" checksum="320F4204B529AC2E" modified="2014-10-01" version="1">MAESAVGFLIKQLSTLLSQESTLLGGLQPDVQFIKDELGSMKAFLRQAEAKEDNDSQLQEWVKQVREVAYDTEDVLNDFAFRFARGHADGFCGGVGKIYNSIKNLKARHRISLEIKDIKARVVEISARRQRYQPLHSTQERDSSSSNVANADYDIRDQALLIEEAKLVGIDQPKKELVSKILDDHSHLQLVSVVGMGGLGKTTLVKKAQRICQGLPQRKKDKDKIDEWEMILHGFGGEVDGSALGFIEEKEGMTATDIAMRYLKELINRSLIQVKDTWADGKLKECGLHDFLREIIVSKSKEQSFTAIITRYCTRWPDKVRHLAIHNFTDNPPQGFSSLKCLRSVETFGYEDPLTTSFLSKFLCGGPKFLKVLNLASAELDSIPKEVFKLFHLEYLDLSGTRVKVIPKSIGQLQNLEFLILAETTIMELPVEILKLRKLRTLTVGREGDYSNNFALWGFKSPDGIGKLTSLESLSCIEVDNGKIVREIGKLVQLRQLSITKLRREDGKELVSSLSRLTNLRELYICSIKEEETLDLQHSVSPRLALLTTLSLSGRLERVPEWLISLQSLRMLALHNSELSEDENAIDCLGHLPNLADLTLYRAYEGETLCFKAGGFRKLRQLGLVQLKRLKWVRVEEESMSSLQEFVIIGCKLMESLPLGLQNLTKLKGLGLADMSDELIHKTQNLDKQSEDYQTISHIPQVGIGHWINGEWKTEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLB3</accession>
    <name>A0A068VLB3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DH200=94 genomic scaffold, scaffold_3786</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00000481001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the thioredoxin family. Plant CITRX-type subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP21392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068VLB3">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLB3"/>
    <dbReference type="Gramene" id="CDP21392">
        <property type="protein sequence ID" value="CDP21392"/>
        <property type="gene ID" value="GSCOC_T00000481001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLB3"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLB3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009657">
        <property type="term" value="P:plastid organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044182">
        <property type="entry name" value="CITRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47834">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN CITRX, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47834:SF2">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN CITRX, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP21392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="161" mass="18244" checksum="355BA9E66ABF7365" modified="2014-10-01" version="1">MDSALSSSSSFHAPPRLGPSGMNLLQTHYSSSFFFNPIPNRNPISTANRPSLLSTQQPSRKLLCIPPAGKYVREDYLVKKLSAKEVQDLVKGERNVPLIIDFYATWCGPCILMAQELDMVWIVIGFSLYVSTMPLLFFFFFKFLLDFLDSYPDESVYCVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLQ0</accession>
    <name>A0A068VLQ0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_1422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00003849001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG740506">
        <property type="protein sequence ID" value="CDP20608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLQ0"/>
    <dbReference type="STRING" id="49390.A0A068VLQ0"/>
    <dbReference type="Gramene" id="CDP20608">
        <property type="protein sequence ID" value="CDP20608"/>
        <property type="gene ID" value="GSCOC_T00003849001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLQ0"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLQ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47715">
        <property type="entry name" value="TRYPTOPHAN/TYROSINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47715:SF1">
        <property type="entry name" value="TRYPTOPHAN_TYROSINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="192" mass="20886" checksum="32ED1244AC7F54CD" modified="2014-10-01" version="1">MKVPILNAVNRSALSAVQAFAFSALATSLIGYAVSFPKQLADTLEFIFAKSNSRQMRSQGPQGFQNEVGKIGQTTFTYAQGPGNAGRISYSGLNVHSGSKFNSACVWNSLRRFVMPFVLGLPVLVAALFPSTFSRALDYAGIYANCFLFGILPPVMMHVYQQQTKRRITILPGGNFGLLVLFSIAVVLSIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLX6</accession>
    <name>A0A068VLX6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_5310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00011319001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLX6"/>
    <dbReference type="Gramene" id="CDP21622">
        <property type="protein sequence ID" value="CDP21622"/>
        <property type="gene ID" value="GSCOC_T00011319001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLX6"/>
    <dbReference type="OrthoDB" id="786908at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLX6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140:SF39">
        <property type="entry name" value="LATE BLIGHT RESISTANCE PROTEIN HOMOLOG R1B-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="341"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="622"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="935" mass="107506" checksum="DC7926FFC4B97CD9" modified="2014-10-01" version="1" fragment="single">HKTRRRQRKRKKKKKKKKKKRGFGGLCYLIVMAFSALLHKGTTVTREPQTYIHVLTAAKLSRSSDISDLKKNKHLVADFMEYLVPNIMALLESCTSTPVPIMNQMLKFVEELRFLTILLRHQEKFKELCHEMKNLIGVVACDAAVVIFSLSVNQIKGGLAKETDLALFHLLKVLKFIRAEVTDPVTLLFSPFGFSRTNELGSMDFLLENLKELENCSETDDSIAFPKDQIHTVLEDLIFLRSFLVKIADQRNRNGKLQALWSRVMEVAHRAEFVIDSIVVGDKHEYLERVARDIQLLRTEALETYDSTMHDCGAQRTTQKSFRIESKCRTPMLNEVLVGLDDEVKAIIHSLIRGSKLLDFVSIVGMAGLGKTTLANRVYNDPLILSHFYIRAWCTVSQVYSMHSLLVELLRSISSKSLDEYQEKDENDLAHMLYKLLKRNRYLIFLDDVWEIKAWNLLERALPDDGNGSRILFTSRIQLQFKPDTKAHHLRHLTEEESWKLLQKKLFEKEAFPSTLGKVGSRIAKLCRGLPFTVVLVAGILANTAEDCWEEVTESLTSSIVLDDEYCMKTLELSYSHLSDDLKPCLLYFVCNPMYGELMLEFPNVRRLLLFKGDDLGFWLPKLLRVLDLGELVFRAYFPMEVFLLVHLRYLALRTKEVNFVPAAIANLSRLQTFLLRGNGIDCLLPKTIWSIKTLRHLWITDPDAGFMFPVENLEVSPGLDHLDTLSLAIDPSSQNLQKMLTKLPNIRRLRCEMTESTRIGNGILGFDCLSQLESLTLCLFHGYGFKFPLNLKKLTLFCNKQPWSEISTIGKLPKLEVLKLLHDSFVGEEWEMKEGEFPSLRVLKLRALWDFRSWTASSDNFPHLEKLVVEWCRELEEVPFCLGECPTLEMIEVRGCRESVASSVKQIQQEQIDMGNEVLKILIEDPWSSSEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMF4</accession>
    <name>A0A068VMF4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_6682</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00005777001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
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                <person name="Noel B."/>
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                <person name="Zhang Q."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
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                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">cv. DH200-94</strain>
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        <text evidence="6">Required for protein transport from the endoplasmic reticulum to the Golgi apparatus.</text>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC13 HOMOLOG B"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP21792.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="299" mass="32412" checksum="92B7994FBCAF8F85" modified="2014-10-01" version="1">MPGQKIETGHQDTVHDVAMDYYGKRLATASSDNTIKIIGVSNSNSQPLATLSGHQGPVWQVAWAHPKFGSLVASCSYDGKVIIWREGNQNEWSQAHLFGDHKASVNSIAWAPHELGLCLACGSSDGNISIFTARSDGSWDTSQIDQAHPVGVTSVSWAPSTGPGALVGSGVLDPVQKLASGGCDNAVKVWKLYNGIWKMDCFPALQMHTDWVRDVAWAPNLGLPKSTIASASQDGRVITWTVMREGDQWEGKVLKDFKTPVWRVSWSLTGNILAVADGSNNVTLWKEEVDGEWQQVTTV</sequence>
</entry>
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    <accession>A0A068VMZ1</accession>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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                <person name="Munoz A."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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    </reference>
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    <dbReference type="PhylomeDB" id="A0A068VMZ1"/>
    <dbReference type="Proteomes" id="UP000295252">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="121" mass="13885" checksum="60813CE60AC9546B" modified="2014-10-01" version="1">MAWDVLRRTFLWEKVQPYLEETAFDEKPARRNTVPSAPEINLEATPSRARNRMITRKCTNLSHLLTLRSQGTKMGCRLAAPSVENVHGKVVGRSAARHQKSDAEHHIFVNIIWHLLISDFL</sequence>
</entry>
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    <accession>A0A068VNF0</accession>
    <name>A0A068VNF0_COFCA</name>
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        <submittedName>
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    <gene>
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    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
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            <taxon>Gentianales</taxon>
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            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
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                <person name="Gayraud T."/>
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                <person name="Jamilloux V."/>
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                <person name="Leclercq J."/>
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                <person name="Librado P."/>
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                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140:SF37">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="105"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP22186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="439" mass="51096" checksum="2C740C5FA0EFDC88" modified="2014-10-01" version="1">MWVAEGIMQKRDAESLEETAAYDDVERLCRRNMVQVAEMTIDERIKSCRVHDLLRDVAIRKAEDENFFQIHDTRDDKISAKSRYLAVHTLPRDKNYFGSSTPPLRSLLFFNIRRYGEDISLSFKSFRKLRIVDLENVEMGYDLPEGIGEFRLLRYLGLRRTSIERLPHSFGFLRNLQTLDIRNINRVIVSNFIWKLESLRHLYANDIMSNVPLKIEGLRNLQTLSRIHFDHIMHNDMTTLTSLQKLGIWVDGTSEIDKLCTHLSVVGSLKTLHLYCLEQPQSLAGLSKLHHVTALKLFGKGLRTLPPDFPPNLSRLSLKETRLGADPMPVLEKLGQLSFLKMKDAYERQQHMGISGNGFHQLKFLELRYLRVDEIKVEEGALPQLRCLRIRECYRLEKLPEELKHISSLDKLELVDMPKDFIRRLDADMVSSVPNLRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQR6</accession>
    <name>A0A068VQR6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_9718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00013707001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG748802">
        <property type="protein sequence ID" value="CDP22063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQR6"/>
    <dbReference type="STRING" id="49390.A0A068VQR6"/>
    <dbReference type="Gramene" id="CDP22063">
        <property type="protein sequence ID" value="CDP22063"/>
        <property type="gene ID" value="GSCOC_T00013707001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQR6"/>
    <dbReference type="OMA" id="HEFITNT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQR6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45136">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45136:SF2">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="54"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP22063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="293" mass="31777" checksum="6CB963FB2BDE4485" modified="2014-10-01" version="1">MTSDLAAGSDAVRSVFAIQDRYSQIDPEDRKGHMTEKIIGHTEVLYELLASWALSNVDFAYPARQDVIIFKGFSLTFEAGKSTAVVGQSGSGMSTIISLIERFYSPLGGTVMIDGQDIKSYHLRCSRRHIALVSQEPPLFEGTIRQNLAYCASEDVNESEIIVASKAANAQDFVAALQDGYDTWCGDRGLQLSGGQKQRIAIVAILKNPAILLLDEATSALDSQSEKLLQGALEGVMVGRTSVVVAHRLSTIQCCDIIAVLDKGKVVEKRTHSSLMTKGPNGAYYSLFSQPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM94</accession>
    <name>A0A068TM94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014658001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM94"/>
    <dbReference type="STRING" id="49390.A0A068TM94"/>
    <dbReference type="Gramene" id="CDO97341">
        <property type="protein sequence ID" value="CDO97341"/>
        <property type="gene ID" value="GSCOC_T00014658001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM94"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM94"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000007">
        <property type="entry name" value="Inorganic pyrophosphatase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="292" mass="32653" checksum="915189F5239B327C" modified="2014-10-01" version="1">MVAAGVMVSLIPGIGSTWPLTKSPFFRRSSTISLRFISENTKRLEQQGHAIRCNFNHPGYQIQEEGQVDSHDYRVFLLDNTGKKISPWHDIPLHVGNGVFNFVAEISKDSNLRMELATDELYTPLKQDKIRGRIRCNMKWNYGLLPQTWEDPSSANPEVDGAFGDNDPVDVVEIGSTCAKVGEVLRVKPLATLALIDEGQLDWKIIAVSLDDPRCSLVDDVHDIEKYFPATLTAISEFFRDYKVYDGIPGNKFGLGNKPANKDYAVKVIRETNEAWTKLVTRSIPAGELSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMR9</accession>
    <name>A0A068TMR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00014929001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMR9"/>
    <dbReference type="FunCoup" id="A0A068TMR9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMR9"/>
    <dbReference type="Gramene" id="CDO97551">
        <property type="protein sequence ID" value="CDO97551"/>
        <property type="gene ID" value="GSCOC_T00014929001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMR9"/>
    <dbReference type="OMA" id="FLDAPMT"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMR9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF13">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="5">
        <location>
            <begin position="174"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="31586" checksum="F61A65E3EFE51423" modified="2014-10-01" version="1">MSACYPTTITLTQTRIGWVGIGVMGSAMASRLLSAGYSVTVYDRTPSKAAPLQSKGAHLAPSVADLARASDVVFTMLGHPSDVRQIVLENLVPSLNPNSVIIDHTSSHPTLAKQIYDSALERHCHSVDAPVSGGDIGARDGKLAILAGGDEDVVKWLKPLFDEMGRVTYVGGPGKGQHCKIANQITAGANLLGLSEGLVFAEKAGLDKLKFVEAVRGGAAGSMVMELFGDRMINKDFKPGGVAEYMVKDLGMGVDVGEEEGDEVVVLPGAALIKQLFASMVANGGGKLGTQGLISVIEKINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMS7</accession>
    <name>A0A068TMS7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00014493001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMS7"/>
    <dbReference type="FunCoup" id="A0A068TMS7">
        <property type="interactions" value="1931"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMS7"/>
    <dbReference type="Gramene" id="CDO97224">
        <property type="protein sequence ID" value="CDO97224"/>
        <property type="gene ID" value="GSCOC_T00014493001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMS7"/>
    <dbReference type="OMA" id="GRQAHQK"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMS7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF81">
        <property type="entry name" value="21S RRNA PSEUDOURIDINE(2819) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="194"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="477" mass="53480" checksum="0754EA3CFBA24C9D" modified="2014-10-01" version="1">MADRSLLRRVILRSTPLATLFVLGKSRVLTCEEGRHLYSSTACEKKLEPENEKTTISKKGNWYALPPFTPSVDGAALGKTIAHRQTEKKHKASDTTSTSTMTALKWVTRCCPELPRSLVQKLFRLRQVRRDSYNVEVRQRQLKRVAAKDLMNSGDRIVLPVSIQKVPSAKTDSTFSEEEMKFLHSMVLFKDPAVIVVNKPPGMPVQGGIGIKRSLDELAAKYLRFDDSESPRLVHRLDRDCSGILVMGRTQLSATTLHSIFREKTLEASEYDLDSKRRIVRKTYWALVIGSPRRSKGIISKPLGKVVVDNGKSDRITVLDDVQSSLAQYAVTEYEVIGSSCHGYSWLELSPLTGRKHQLRVHCAEVLGTPIVGDYKYGWQAHRNLKNPGPSALTRDHNEGLPEEGLDPFSLNLGNGSILDKQPRLHLHCREMVLPNISLALQRAKSITDLDLEDVKTIKFDAPLPSHMQKSWNALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMT9</accession>
    <name>A0A068TMT9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="7">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00014634001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular space</location>
            <location evidence="7">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="7"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMT9"/>
    <dbReference type="FunCoup" id="A0A068TMT9">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMT9"/>
    <dbReference type="Gramene" id="CDO97322">
        <property type="protein sequence ID" value="CDO97322"/>
        <property type="gene ID" value="GSCOC_T00014634001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMT9"/>
    <dbReference type="OMA" id="CVWNGNP"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMT9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104066" description="Xyloglucan endotransglucosylase/hydrolase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO97322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="296" mass="33780" checksum="647F4D66360FA41E" modified="2014-10-01" version="1">MNASRFIFLIGVLSVELIQISIASVVSAGDFNRDFFVTWSPSHVNTSADGRARSLKLDPDSGSAFASNDMFLFGQFDMQIKLIPGNSAGAVVAFYLSSNQPNRDELDFEFLGNADGGQQQPYILQTNVYVDGFDDREERIKLWFDPTKDFHTYTILWNIHQIVFMVDWVPIRTFRNHADKGVAFPRWQPMALQASIWDGSSWATGGGKDKIDWSRGPFVASFQNHKIDACIWKGSAGFCTAESPTNWWNQGGSNSLTSAQRRLFRWVRKYYVIYDYCQDRPRFKNNLPKECSLPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN25</accession>
    <name>A0A068TN25_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014768001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN25"/>
    <dbReference type="Gramene" id="CDO97427">
        <property type="protein sequence ID" value="CDO97427"/>
        <property type="gene ID" value="GSCOC_T00014768001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN25"/>
    <dbReference type="OMA" id="CKWICNE"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN25"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000027">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1445">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="361" mass="40493" checksum="B1A308E0A71F6D89" modified="2014-10-01" version="1">MSFALEAAEEIGVPGVLFRTANACSLMCYKRVEHLVKKGLVPLKDASYLTNGYLDTKMDWLPGMPEIRLRDFPSFIRTTDPDNIMLNFAITESARASQASALMINTFDSLEFDVLNSLSSMCPPIYAIGPLQLLFNQLPQDSHQSIGSNLWKEDAECIQWLNTKEANSVLYVNFGSIAVLTPEQLVEFAWGLANSNKSFLWILRPDLVVGDSAILPPEFAEETKERGMITGWCAQEQVLKHSSTGGFLTHSGWNSILESLCCGVPVICWPFFADQLINCRYSCQEWGIGMEIDTNVKRNEVEKIVRELIEGDKGREMKRKATDWKLKAEEATGLDSSSYLNFNRLVKEVILSKAKLEKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNN4</accession>
    <name>A0A068TNN4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminomethyltransferase folate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00014940001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNN4"/>
    <dbReference type="FunCoup" id="A0A068TNN4">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNN4"/>
    <dbReference type="Gramene" id="CDO97559">
        <property type="protein sequence ID" value="CDO97559"/>
        <property type="gene ID" value="GSCOC_T00014940001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNN4"/>
    <dbReference type="OMA" id="DHRTIPH"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000021">
        <property type="entry name" value="Slr0635 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF14">
        <property type="entry name" value="GLYCINE CLEAVAGE T-PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="117"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="360"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO97559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47615" checksum="0A03E002CB5B2849" modified="2014-10-01" version="1">MSWITGTAPASATSAPVNLFPPPSSSAPARYSVLPPHYTRLSYPTSTSYRFTRRSRQPLLSYTLSSLPSLPHLKDAFRALPFHPSPPPIDHDHSFDTVTNADDRISIEAFHSDDEALDAAEKGAVVVDLSHYGRIRVGGEDRIQFLHNQSTANFECLSVGQGCDTVFVTPTARTIDIALAWIMKNAITLVVSPVTCESISKMLEKYIFISDKVEIQDITKQTCMFALVGPASNQIMERLGLIDLIGQPYGSHNHYSVNGKPVTVAVGNVISEEGFSFLMSSDSAGTVWKALVAQGAITMGSGAWETFRILQGRPAPGKELTDEFNVLEAHLWNGVSLNKGCYKGQETISRLVTYDGVKQRLWGIRLSSLVEVGSAVTVDGKKVGKLTSITAGKRASEPFGLGYIKRKAASKGDTVIVGGNVVGTVVEVPFLAQQRVLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ27</accession>
    <name>A0A068TQ27_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021999001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ27"/>
    <dbReference type="FunCoup" id="A0A068TQ27">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ27"/>
    <dbReference type="Gramene" id="CDO98029">
        <property type="protein sequence ID" value="CDO98029"/>
        <property type="gene ID" value="GSCOC_T00021999001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ27"/>
    <dbReference type="OMA" id="MIEDTDM"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ27"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000004">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF78">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="98" mass="10866" checksum="441107375CC24C2B" modified="2014-10-01" version="1">MLEGKALIQDTDMPVKMQIQAMASASQALDLFDVVDCKSIATHIKKDFDRRYGSGWQCVVGSNFGCFFTHTKGTFIYFTLETLNFLIFKGANSPSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ75</accession>
    <name>A0A068TQ75_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00022488001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ75"/>
    <dbReference type="FunCoup" id="A0A068TQ75">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ75"/>
    <dbReference type="Gramene" id="CDO98406">
        <property type="protein sequence ID" value="CDO98406"/>
        <property type="gene ID" value="GSCOC_T00022488001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ75"/>
    <dbReference type="OMA" id="FLYERYE"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ75"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045064">
        <property type="entry name" value="Reticulon-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994:SF85">
        <property type="entry name" value="RETICULON-LIKE PROTEIN B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="221" mass="24815" checksum="D337C8812925D86F" modified="2014-10-01" version="1">MASRLRASDNGTATKVKLFGRGQRSIHDALGGGKAADLLLWRKKRVAGAVLAGVAVVWYLFEVVEYNFITLLCHVLITSMLALFIWSTAANFFQWTPPNIPKTALKESTFTEVASTFHSKFNQILSELLRVACGNEPKLFFLGLISLWILGVIGNYISTLNLLFFSILCAETLPFLYEQYEEEADNLAGKLYKQMRSTYRKVEADVLAKIPRGPLKEKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQW8</accession>
    <name>A0A068TQW8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DhaK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00022805001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQW8"/>
    <dbReference type="STRING" id="49390.A0A068TQW8"/>
    <dbReference type="Gramene" id="CDO98641">
        <property type="protein sequence ID" value="CDO98641"/>
        <property type="gene ID" value="GSCOC_T00022805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQW8"/>
    <dbReference type="OMA" id="MLSAACP"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQW8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="6">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="39461" checksum="934F052FD21DE77B" modified="2014-10-01" version="1">MILNNDTFFFCFDITDVVTEFIEGLVETYPGLQYLDGFPEVKVVLRADISGSTHDKVAVISGGGSGHEPAQAGFVGEGMLTAAICGDVFASPPADSILAGIRAVTGPMGCLLIVTNYTGDRLNFGLAAEQAKSEGYKVEMVIVGDDCALPPPRGIAGRRGLAGTVLVHKVAGAAAASGLSLSAVAAEAKRASEFIGTMGVALSVCTLPGQVTSDRLGPGKMELGLGVHGEPGAAVADLQPVDVIVSHVLKQILSLETNYVPITRGSRVVLLINGLGGTPVMELMIAAGKVVPMLQLEHGLAVERVYTGSFMTSLDMAGFSITVMKANEEILNRLDAPTRAPCWPVGVVGNRPPAKIPVPLPLSLSTKSDETLSRPEQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRK7</accession>
    <name>A0A068TRK7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025828001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant rapid alkalinization factor (RALF) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRK7"/>
    <dbReference type="STRING" id="49390.A0A068TRK7"/>
    <dbReference type="Gramene" id="CDO98876">
        <property type="protein sequence ID" value="CDO98876"/>
        <property type="gene ID" value="GSCOC_T00025828001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRK7"/>
    <dbReference type="OMA" id="YANCLPP"/>
    <dbReference type="OrthoDB" id="1613518at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRK7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008801">
        <property type="entry name" value="RALF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136:SF95">
        <property type="entry name" value="PROTEIN RALF-LIKE 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05498">
        <property type="entry name" value="RALF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="138" mass="15597" checksum="EA90E9C0FBE65DC4" modified="2014-10-01" version="1">MVKPSAGLFLISATLFAATMLVSFWAVGVAASGSHELSYYFPAVTTSTASFCNGGSIESCLMSEQEEEGDDDDQEELEMDSETNRRILYWRRRYISYGALTRDRVPCSRRGYSYYNCRPGRPVNPYNRGCNAITRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRY0</accession>
    <name>A0A068TRY0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00026024001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRY0"/>
    <dbReference type="FunCoup" id="A0A068TRY0">
        <property type="interactions" value="2546"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRY0"/>
    <dbReference type="Gramene" id="CDO99021">
        <property type="protein sequence ID" value="CDO99021"/>
        <property type="gene ID" value="GSCOC_T00026024001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRY0"/>
    <dbReference type="OMA" id="DYFRMAH"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRY0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010078">
        <property type="term" value="P:maintenance of root meristem identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010231">
        <property type="term" value="P:maintenance of seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010492">
        <property type="term" value="P:maintenance of shoot apical meristem identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000016">
        <property type="entry name" value="Chromatin structure-remodeling complex protein SYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000755">
        <property type="entry name" value="Probable ATP-dependent DNA helicase CHR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="364"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="665"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="941"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO99021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1036" mass="118874" checksum="7D9EF499134ABAE5" modified="2014-10-01" version="1">MPTSLVAAGLDLVRLLPKELRRKAGMSSYGDLMADFEVAVLKQRENCMSGSGLGELKESNFQSHIHRRLTELEELPASRGEDLQTKCLLELYGLKLVELQNKVRSEVSAEYWLRLHCTSPENQLFDWGMMRLRRPLYGIGDAFAVDTEDPLKKKRDAERLSRLEEEERNHVETRKRKFFADLLNAVRELQLQVQASQKRRKQRNDGAWHAKQRQRATRAEKLRFQALKADDQEAYMKMVEESKNERLTMLLGKTNDLLVRLGAAVQRQKDAEHQGIEPLEGSAADLPELSASKTETPGQSRPLEDEDVLDNETNSPKKGGDLLEGQRQYNSVVHSIEEKVTEQPAMLQGGELRQYQLEGLQWMLSLFNNNLNGILADEMGLGKTIQTISLIAYLMENKGVTGPHLIVAPKAVLPNWINEFATWAPSVVAVLYDGRADERKAIKEEFFIEGKFNVLITHYDLVIRDKKVLNKIQWNYLIVDEGHRLKNHDCVLSRTIVTGYNIRRRLLLTGTPIQNSLQELWSLLNFLLPNIFNSVENFEEWFNAPFADRGNVTLTDEEELLVIRRLHHVIRPFILRRKKDEVEKFLPGKIQVILKCDMSAWQRVYYQQVTDVGRVGLDNGTGKSKSLQNLSMQLRKCCNHPYLFVAEYNMWRKEEVFRASGKFELLDRLLPKLCKAGHRVLLFSQMTRLMDILEIYLQLHDFKYLRLDGSTKTEERGSLLRQFNAPDSPFFMFLLSTRAGGLGLNLQTADTVIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSVGSIEEVILERAKQKMGIDAKVIQAGLFNTTSTAQDRREMLEEIMRKGTSSLGADVPSEREINRLAARSDEEFWLFEKMDEDRRRKESYRSRLMEEHEVPDWAYAAPETNERKGKGFQYEAANITGKRRRKEVVYADTYGELEWTKAVENGDLAKHSDKGKKRRLDDPTLNNDLPNNSAGGEKRLPVVKNETVAVAAEITRTSSGSTSVPKRLKYEDANSSKIDHSDRKEGSLDGLTWKAHQKKRSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSA8</accession>
    <name>A0A068TSA8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025795001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSA8"/>
    <dbReference type="STRING" id="49390.A0A068TSA8"/>
    <dbReference type="Gramene" id="CDO98854">
        <property type="protein sequence ID" value="CDO98854"/>
        <property type="gene ID" value="GSCOC_T00025795001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSA8"/>
    <dbReference type="OMA" id="KECLMEW"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSA8"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF38">
        <property type="entry name" value="UDP-GLUCURONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="23610" checksum="E5E8DC4C3AF48428" modified="2014-10-01" version="1">MVEGDGKKYMGSSGKSQAIRPRKRLSFVTYPIQYVLEEQRLVCLLIGIGIASLIFTAVPALTSSSSSSTPNHHGWIPDSLTESTHHVPRRIALELSDYDRDQSSNGVARLPVGLKNKRLRVLVTGGAGFVGSHLVDRLMERGDSVIVVDNFFTGRKDNLVHHFSNPRFELIRHDVVEPIMLEVDQIYHLACPASPVHYKYNPVKTIISFSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTZ9</accession>
    <name>A0A068TTZ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome non-ATPase regulatory subunit 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00026637001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 19S regulatory particle (RP/PA700) base subcomplex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The RP/PA700 complex is composed of at least 17 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTZ9"/>
    <dbReference type="FunCoup" id="A0A068TTZ9">
        <property type="interactions" value="3990"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTZ9"/>
    <dbReference type="Gramene" id="CDO99454">
        <property type="protein sequence ID" value="CDO99454"/>
        <property type="gene ID" value="GSCOC_T00026637001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTZ9"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTZ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000048">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="12">
        <location>
            <begin position="801"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="875"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="959"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="962"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO99454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109100" checksum="353C0CA69D13988A" modified="2014-10-01" version="1">MAAAATMVSSAGMLLAMLNESHPQLKQHALSNLNAFVDFYWPEISTSVPVIESVYEDEEFDETQRQLAALLASKVFCYLGELNDSLSYALGAGPLFDVSEDSDYVRTILAKAIDEYADLKTKAAESNEAAKIDPRLEAIVERMLDKCITDGRYQQAVGMAIECRRLDKLEEAVIRSDNIQATLSYCTDVSHNFVNSREYRREVQRLLVRVFQKLPSPDYLSICQLLMFLDGPEDVAGVFEKLLRSENKDDALLGFQIAFDLVENEHQAFLLKVRDRLSSPKGEPSVAAQSGSAELHSSRVNTTSEDVQMTEGSQDSEGNVSHADPKEAIYAERLSKIKGILSGETSIQLTLQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYANALMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHRGHLQQGRSLMAPYLPQSGAGGGGSPYSEGGALYALGLIHANHGEGIKQFLRESLRSTNVEVIQHGACLGLGLAALGTADEDIFDDIKNVLYTDSAVAGEAAGISMGLLMVGTASEKASEMLAYAHETQHEKIIRGLALGIALTVYGREEGADTLIEQMTRDQDPILRYGGMYALALAYSGTANNKAIRQLLHYAVSDVSDDVRRTAVLALGFVMYNDPEQTPRIVSLLSESYNPHVRYGAALAVGISCAGTGLSEAISLLEPLTSDVVDFVRQGALMAMAMVMVQISEASDSRVGAFRRQLEKIILDKHEDTMSKMGAILATGILDAGGRNVTIKLLSKTKHDKVTAVVGLAVFSQFWYWYPLIYFVSLSFSPTAFIGLNYDLKVPKFEFLSHAKPSLFEYPKPTTVATTTSAVKLPTAVLSTSARAKARASKREAEQKAIADKAFGAELPSGSGTSGKAKSGDKDGESMQVDGAAEKKSEPEPNFEVLTNPARVVPAQEKFIKFKEDSRYVPVKLAPSGFVLLKDLRPTEPEVLSLTDSPSSTTSNAGASATAQQGTGSAMAVDEEPQPPQPFEYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUC6</accession>
    <name>A0A068TUC6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00025939001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUC6"/>
    <dbReference type="FunCoup" id="A0A068TUC6">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUC6"/>
    <dbReference type="Gramene" id="CDO98953">
        <property type="protein sequence ID" value="CDO98953"/>
        <property type="gene ID" value="GSCOC_T00025939001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUC6"/>
    <dbReference type="OMA" id="YQHVRHH"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUC6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18096">
        <property type="entry name" value="SpoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF7">
        <property type="entry name" value="OBP33PEP LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO98953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="221" mass="24744" checksum="BF59931398EEB13F" modified="2014-10-01" version="1">MENEKRYESYVLIHNIAKRHNVGTLARSCTAFGVSELILVGRRDFNAFGSHGSTSHLNFRHFHSLSLAKSFLKERDCDICGVEITDDAVAVNQHPFKRSTAFLLGNEGTGLSAKECEICDFFVYIPQYGCGTASLNVTVAASIVLHHFGVWAGFSERTREGNKFVVAERPTKQERKNYCAETTESIVEERRLKRENTSNGFFDESVKDDSSSNLLDGLFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUY3</accession>
    <name>A0A068TUY3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026188001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUY3"/>
    <dbReference type="Gramene" id="CDO99143">
        <property type="protein sequence ID" value="CDO99143"/>
        <property type="gene ID" value="GSCOC_T00026188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654237" evidence="1">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="144" mass="16245" checksum="C86C01B8462F671D" modified="2014-10-01" version="1">MLISLLFKLFSQGLNASSKLLTPCKACIIAGIHPPYLSHFIEHFVCTFSTTTPCVSVPILLSFLVSPSGFPEKLLILIFKPSFSPFLLSELLLWDFSKTTLWPPLGLHFPSKLSWFPLFPSRFPTKPFWVILKLPLFSSESSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVC1</accession>
    <name>A0A068TVC1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00032077001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVC1"/>
    <dbReference type="FunCoup" id="A0A068TVC1">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVC1"/>
    <dbReference type="Gramene" id="CDP00205">
        <property type="protein sequence ID" value="CDP00205"/>
        <property type="gene ID" value="GSCOC_T00032077001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVC1"/>
    <dbReference type="OMA" id="KHTRYLI"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVC1"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20543">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20544">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D2/4-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="82"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="179"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP00205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="341" mass="38297" checksum="BDD5A75DC6649B73" modified="2014-10-01" version="1">MSVSYSDCFSDLLCGEDSSTIFSGDDLPECSSEIESQHPPEDLEESIIGLIEHEKQYVPGIDYLESFQSQSLDASARADSIAWILKVQRYYGFQPLTAYLSVNYFDRVLYSRRLPQTKGWPLQLLSVACLSLAAKMEEPLVPPLLDLQVEGAKYIFEPRTIGRMEFLVLNTLDWRLRSITPFSFLSFFAHKVDPTGTYAGFLISRANDIILSHIQDASFLEYRPSCIAAVAILSAARDLPIFSFLSPEYAESWCDGLHREKIISCYGVVQQIIIDNRPRKSPKFLPQLRVMSRMSLASTESSSSSSSTSSNSSSSSSSLSSCKRRRLENYLWTDDDKGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVL1</accession>
    <name>A0A068TVL1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026537001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVL1"/>
    <dbReference type="Gramene" id="CDO99383">
        <property type="protein sequence ID" value="CDO99383"/>
        <property type="gene ID" value="GSCOC_T00026537001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVL1"/>
    <dbReference type="PhylomeDB" id="A0A068TVL1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218:SF3">
        <property type="entry name" value="OS07G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7192" checksum="031E82EA45855995" modified="2014-10-01" version="1">MIFGYLDARSVVLSLIVSCRWHGVACSDRLWAPKCEELWHGKAHISRISKFRGLSKLAAYSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVV1</accession>
    <name>A0A068TVV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00029066001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVV1"/>
    <dbReference type="Gramene" id="CDO99473">
        <property type="protein sequence ID" value="CDO99473"/>
        <property type="gene ID" value="GSCOC_T00029066001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVV1"/>
    <dbReference type="OrthoDB" id="812961at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVV1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044809">
        <property type="entry name" value="AUF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31215">
        <property type="entry name" value="OS05G0510400 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO99473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36250" checksum="E91EA0755C086D96" modified="2014-10-01" version="1">MEDSLHQTILLPEAPVHSILKEEESSKNPFERLPDDLIVSHILDKIYEAKSLCLISLVSRRFSSLVYQTHVLSLRIALYWGRAPGQVLDFETCAKFLAKFSSIKSLYVELDYSRNLSGDVDPPVVKWKIDTESASFMILTARSLQLGTTDDDNDQGNAFNPDHFRLLRRFFNCCMIMACWWFKFVEKLVRLLPESLQKVVVADSKREGKVHFARRDIIRMRNGNSNFGVGETNVKAWHAPFLILPLSGYVMKTVTLFIIKGTDRSDSDDLLIAKEAFDGEDDHQVYVEAIEETMKRDLISQDVLPARDFSFYLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWI0</accession>
    <name>A0A068TWI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="17">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00032345001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Plastid</location>
            <location evidence="4">Amyloplast</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="17"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWI0"/>
    <dbReference type="STRING" id="49390.A0A068TWI0"/>
    <dbReference type="Gramene" id="CDP00412">
        <property type="protein sequence ID" value="CDP00412"/>
        <property type="gene ID" value="GSCOC_T00032345001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWI0"/>
    <dbReference type="OMA" id="DLDPQKF"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009501">
        <property type="term" value="C:amyloplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000105">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF27">
        <property type="entry name" value="ALPHA-1,4 GLUCAN PHOSPHORYLASE L-2 ISOZYME, CHLOROPLASTIC_AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="13" id="KW-0035">Amyloplast</keyword>
    <keyword evidence="14 17" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="11 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="583"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP00412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1039" mass="118416" checksum="FCBC0E8C77901FE4" modified="2014-10-01" version="1">MQKILLIDSFIHSLTPSPKIRLEKERASPLATAKTGNSGDLSKVSAEQSNLMAATAMPSTNSIFCHSCIFTDFRAKLKSRILLLNHTSRIRNSRSFRYYSPSRRTGCRFFAKNVASHQQQQLQDPSTNRSDGIALDAFQPDSASIASSIKYHAEFTPLFSPEQFDLPKAYYATAESVRDMLIINWNATYDFYEKMNVKQAYYLSMEFLQGRALLNAIGNLELIGRYAEALKKLGYRLEDIIEQEPDAALGNGGLGRLASCFLDSMATLNYPAWGYGLRYKYGLFKQIITNDGQEEVAENWLEMGNPWEIVRNDVSYPVKFYGEVTEGPDGRKEWAGGEDIIAVAYDVPIPGYKTQTTLNLRLWSTKVAAENFDLRAFNAGEHAKAYDALKKAEKICYVLYPGDESLEGKTLRLKQQYTLCSASLQDIIARFERRSGDSVNWNQFPEKVALQMNDTHPTLCIPELIRILMDVKGLKWNEAWEITQRHVCFISELFHVTVAYTNHTVLPEALEKWSFELLQELLPRHVQIIEMIDEELVNTIIAEYGTEDLHLLEEKLRQMRIFDNIELPAAILESPIKSQESVIEVPAQDESPDKEKEAEDGKEEAEDGKEETEALDNAKDPESEIKVSFEPDPKQPKRVRMANLCVVGGHAVNGVAEIHSEIVKEDVFNEFYKLWPEKFQNKTNGVTPRRWIQFCNPELSRIITKWSGTPDWLTNTEKLVELRKFADNDELQSEWREAKRRNKMKVVSFLKEKTGYVVSPDAMFDVQVKRIHEYKRQLLNIMGIVYRYKKMKEMSPEESKRKFAPRVCIFGGKAFATYVQAKRIVRFITDVGATVNHDPEIGDLLKVVFVPDYNVSVAEVLIPGSELSQHISTAGMEASGTSNMKFSMNGCILIGTLDGANVEIREEVGENNFFLFGAKAHEIAGLRKERAEGKFVPDPRFEEVKKFVRSGVFGPYNYEELMGSLEGNEGYGRADYFLVGKDFPSYIECQEKVDEAYQDPKRWTKMSILNTAGSFKFSSDRTIHQYARDIWMIEPVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWT3</accession>
    <name>A0A068TWT3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00029512001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWT3"/>
    <dbReference type="FunCoup" id="A0A068TWT3">
        <property type="interactions" value="2577"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWT3"/>
    <dbReference type="Gramene" id="CDO99818">
        <property type="protein sequence ID" value="CDO99818"/>
        <property type="gene ID" value="GSCOC_T00029512001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWT3"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWT3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO99818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="9952" checksum="C2A2A9FB0A322C75" modified="2014-10-01" version="1">MATVPVNPKPFLNNLTGQPVMVKLKWGMEYKGFLVSVDSYMNLQLANAEEYIEGQFTGNLGEILIRCNNVLYIRGVPEDEEVEDADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXF3</accession>
    <name>A0A068TXF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SOSEKI DIX-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00029805001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms long polymer filaments with other SOKs proteins polymers (e.g. SOK1, SOK2, SOK3 and SOK4) crucial for polar localization and biological activity. Binds to ANGUSTIFOLIA (AN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SOSEKI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXF3"/>
    <dbReference type="STRING" id="49390.A0A068TXF3"/>
    <dbReference type="Gramene" id="CDP00043">
        <property type="protein sequence ID" value="CDP00043"/>
        <property type="gene ID" value="GSCOC_T00029805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXF3"/>
    <dbReference type="OrthoDB" id="1280899at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000067">
        <property type="term" value="P:regulation of root morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090708">
        <property type="term" value="P:specification of plant organ axis polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010369">
        <property type="entry name" value="SOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048351">
        <property type="entry name" value="SOK_DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021182">
        <property type="entry name" value="SOK_magnoliopsida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083:SF25">
        <property type="entry name" value="PROTEIN UPSTREAM OF FLC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083">
        <property type="entry name" value="UPSTREAM OF FLC PROTEIN (DUF966)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06136">
        <property type="entry name" value="SOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031043">
        <property type="entry name" value="UCP031043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOSEKI DIX-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="22692" checksum="32CBC0ECEFD93C26" modified="2014-10-01" version="1">MAVANSRPSTELLMPKKWNERSDRSPERAKICSEHPKFNSILDGKVPVIYYLARNGHLEHPHFIQVPLSSSHGLYLRDVINKLNFLRGNGMAHMYSWSSKRNYKNGYVWQDLTEDDLIQPTNDRDYILKGSELLHSSPTIRGQENGITKKKKKGMRKRKEKSVLRKSEFHVLLDTLSSSTHSCLRESANGAPVSRECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXM4</accession>
    <name>A0A068TXM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032885001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXM4"/>
    <dbReference type="STRING" id="49390.A0A068TXM4"/>
    <dbReference type="Gramene" id="CDP00797">
        <property type="protein sequence ID" value="CDP00797"/>
        <property type="gene ID" value="GSCOC_T00032885001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXM4"/>
    <dbReference type="OMA" id="HESHRAT"/>
    <dbReference type="OrthoDB" id="1072116at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052006">
        <property type="entry name" value="MLP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31338">
        <property type="entry name" value="POLYKETIDE CYCLASE/DEHYDRASE AND LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31338:SF16">
        <property type="entry name" value="POLYKETIDE CYCLASE_DEHYDRASE AND LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="153" mass="17538" checksum="1C7D0A90F219AFCD" modified="2014-10-01" version="1">MADTAEKLEAEINIKSDPDEFFHSFGGKAHQLPNLCSEKLHAIDLHEGDWKTEGSVKHWTYVIDGKVETAKERFKVDEENRIVTLEAIEGDIKEQYKSYKVELQVISKGVSNFAHWSIEYETVKENDPAPTKYLHWLIHAAKDVDASLLKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY38</accession>
    <name>A0A068TY38_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00034704001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY38"/>
    <dbReference type="Gramene" id="CDP01166">
        <property type="protein sequence ID" value="CDP01166"/>
        <property type="gene ID" value="GSCOC_T00034704001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY38"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8597" checksum="01D4703ED12F5109" modified="2014-10-01" version="1">MFAQIFRRLRINGGTSACTRVVVLFPEPLPHYTTRAAAVPEHQKNRFLEEYLVNSLGFSKEEAFSASKKAPMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZP9</accession>
    <name>A0A068TZP9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00036628001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZP9"/>
    <dbReference type="STRING" id="49390.A0A068TZP9"/>
    <dbReference type="Gramene" id="CDP01542">
        <property type="protein sequence ID" value="CDP01542"/>
        <property type="gene ID" value="GSCOC_T00036628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZP9"/>
    <dbReference type="OrthoDB" id="1936684at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056876">
        <property type="entry name" value="Msl2-3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057483">
        <property type="entry name" value="MSL2/3_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045042">
        <property type="entry name" value="YnaI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43634:SF2">
        <property type="entry name" value="LOW CONDUCTANCE MECHANOSENSITIVE CHANNEL YNAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43634">
        <property type="entry name" value="OW CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24956">
        <property type="entry name" value="Msl2-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25237">
        <property type="entry name" value="MSL2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mechanosensitive channel protein 2/3 transmembrane" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel protein 2/3 C-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="107" mass="11801" checksum="04B1C56A790DDA4A" modified="2014-10-01" version="1">MGFQFAGKAVYTAVWVAAASLFMELPGFSTQKWLTAGGLGTVLLTLAGREIFTNFLFKCNDSCNTAISISHLDVNKISSIVADMRKVLAKNPQVEQQRWHRSISGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZR4</accession>
    <name>A0A068TZR4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00034284001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZR4"/>
    <dbReference type="STRING" id="49390.A0A068TZR4"/>
    <dbReference type="Gramene" id="CDP00858">
        <property type="protein sequence ID" value="CDP00858"/>
        <property type="gene ID" value="GSCOC_T00034284001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZR4"/>
    <dbReference type="PhylomeDB" id="A0A068TZR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20618">
        <property type="entry name" value="CYP71_clan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF5">
        <property type="entry name" value="CYTOCHROME P450 71A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654447" evidence="9">
        <location>
            <begin position="18"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="464" mass="53203" checksum="839E068EE4183A67" modified="2014-10-01" version="1">MEISWLLMPFLAWLAAAVLLSRITSTKRPKKNYRPGPKPWPIIGNLHLIDSQPHRSFHSLYHKYGGIMPLWFGGKPLIVASTPEAAKEFLKNHDYNFSSRPANAAGKYIIYNYSDVTWAPTGDKHLFRYTLTIITRTVLGKTYISTKESNDDSAIVTFEELTAMLDKWFVLNGVLNIGDWVPWHNVFDLRGYVKQMKEVDKDYEKFFNFVLEDHKARTKAEKDFVPRDMVDILLNLAEDPNLEVKLSRESVKGLIQDLLLGGTDTSTTTVEFVVTALVKHPHLTEKVTEELDRVVGRDRWVEEDDFPKLPFLEAVVKETFRCYPLCTLLAPRFAMEDCKVAGYNVYKGTTVLVNAWSIGRDPNYWDSPEEFLPERFLEKDIDIKGQNFEPLAFGSSRRRCAGYALGLKAVRSMLSNLLHGFNLKLPDGTKPEDVCMDEVYGFTTHPKVPIKLILEPRLRKDLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U083</accession>
    <name>A0A068U083_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FG-GAP repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037143001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U083"/>
    <dbReference type="FunCoup" id="A0A068U083">
        <property type="interactions" value="1127"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U083"/>
    <dbReference type="Gramene" id="CDP01950">
        <property type="protein sequence ID" value="CDP01950"/>
        <property type="gene ID" value="GSCOC_T00037143001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U083"/>
    <dbReference type="OMA" id="HVLICED"/>
    <dbReference type="OrthoDB" id="270568at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U083"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657221" description="FG-GAP repeat-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="77462" checksum="098D254B12AEF892" modified="2014-10-01" version="1">MRKRDLAILMLSAFAIFFSLQHEGDFSFKEAWYHISDEYPIKYEAERLPPPIVADLNGDGKKEVLVATHDAKIQVLEPHARRVDEGFSEARVLAEVSLLPDKIRIASGRRAVAMATGVIDRNYKRKEPQKQVLVVVTSGWSVMCFDHNLTKLWDVNLQEDFPHNAHHREIAISVSNYTLKHGDSGLVIIGGRMEMQPHLHMDPFEEIELAEKNAEQHRRSASEKEASDNSGMVDLRHFAFYAFAGRSGQLRWSRKKEDIESHPPDASQLIPQHNYKLDAHALNSRHPGEFECRDFRESILGVMPHHWDRREDTLFELAHFRRHKRKTVKKTPGKNMNYPFHKPEENHPPGKDTSKKISNAIGKAVNYAKSAKSKKPLPYIPTITNYTQLWWVPNVVVAHQKEGIEAVHLASGRTICKLHLQEGGLHGDINGDGVLDHVQVVGANGAEQTVVSGSMEVLRPCWAVATSGVPVREQLFNASICHHSPLNLFQHGEFSRGFGRMLDVSSLEVATPILIPTNDGHRHRKGSHGDVVFLTNRGEVTSYSPGLLGHDASWNWQILTGATWSNPPSPSGLTESGQVIPTLKAFRLRPHDGRDLILAAGDQEAVVLSPGGSTLTTVELPASPTHALVTVDFSNDGLTDLILVTSNGVYGFVQTRQPGALFFSTLVGCLIVVMGVLFVSQHLNSIKGKPRPSSGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U171</accession>
    <name>A0A068U171_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039626001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U171"/>
    <dbReference type="STRING" id="49390.A0A068U171"/>
    <dbReference type="Gramene" id="CDP02275">
        <property type="protein sequence ID" value="CDP02275"/>
        <property type="gene ID" value="GSCOC_T00039626001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U171"/>
    <dbReference type="OMA" id="RTHGNTR"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U171"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF452">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="88107" checksum="97E4E2CC52269D98" modified="2014-10-01" version="1">MKGLPSIVPALIQNPTKFTCVKAQLRILSETSSPLSEKFASFLDNCLDIDSLKKLHACILTHGLENNVGLGSKLINSCARFNLLTESKWVFRKIICNDLSLWNSIILGYFRAAHFGEVLGLYVGLRRRKIGINGSVITVGLKSCVELGSLDFGKSLHVDAFKSGLNGDRFVGSSLIGLYNKYDDVDEAAKVFDEITERDVVVYTSMITAYAQVGDNRSCEAFRVAGYMQKEELEPNRITLVSLLQAVSVCGAIKEGKSIHGYAIRKGIGWLDKVFETSLMDMYMKCGFPDKAALSFGNISWKTIGSWNAMITGHLQLGQPLKALQLFLQMVQQNYVPDIITLANGVLSCGYIGHLSGGKSIHGYLLRNGFQLDLVATTALIDMYSKCYQLIQAKEVFDKMHRKDDVSFNVMIAGYLENGFSSQAVEEFHEMVRMDLRPNVSTILNVLSAISDLKDTRQGKCIHGHAFRHGFGENTDIANQLINMYSKCCTMNYARKVFDRIGKKDTVSWTSMITAHVNGGRADEAVILFRLMQKEKLNPDSVTLISLLQALAQLGCLSLAREVHTRVYRILLNEDKPMINCLITAYSNSGKLSIARNLFEHVAKRQLATWNSMISAYGMHGDCVQALKLFDMMKKDKIPPDGLTFTSVLSACSHSGMVNEGLCVFKSMKEEYRLTPSGEHYSCMVDLLSRAGRLEEAYELLKFLPSDQATSALGALLAACRVHGNINMGEIIGRRLLELEPQNPSAYNLVSNLLAEQEKWEEVAKLRSIAERRGLKGFAGNSMIEFGCTGLLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1M1</accession>
    <name>A0A068U1M1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00036583001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1M1"/>
    <dbReference type="STRING" id="49390.A0A068U1M1"/>
    <dbReference type="Gramene" id="CDP01508">
        <property type="protein sequence ID" value="CDP01508"/>
        <property type="gene ID" value="GSCOC_T00036583001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1M1"/>
    <dbReference type="OMA" id="QHRCRIE"/>
    <dbReference type="OrthoDB" id="774313at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1M1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35164">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35164:SF9">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="681" mass="77454" checksum="41A33BBCECC2992F" modified="2014-10-01" version="1">MSLDLICINIYAVSRYGNADFGQKNHPSVLSRTLSASKFCRGDALASQIDSGALKPVGRRSVDRYPSKNRINRVSTMQEQMRQAEDELKTSKEQLDFAEDERSRAFNELREAKRLVYEANMKVNEVLSPRKTGELMTEVKNLKELLANSLKELKMKDEKIECLKLELQEAKQFEVKLAERDASLARWKEEFDKVKGSEAYALDLLSAGEKRIEELENEVQRGNVSEAKMLDSLASQTKQLEQIKIELEESKLEIAALNERIVSSQEPSKQNSSECNRPDRKGENEILIGDAGSTRSEQKLAKQNLSLGKKDANIALSNSKTSLDEMQLLKNELKLAIEAEEKSKKAMDDLALVLKEVATESNQAKEKLSVAYLQLEQVKGEAEQLKVIVRSTEERYEHLLDEAKKEAELHRNTADRLRVEAEETLLAWNGKEMGFVSCIKRAEEERAVAQHENAKLSESLKAAEHKMRAARDESYKLRDILKQAINESNAAKAAAGLARDENSHFKDILAEKDEALYFLTQENERLRINEVAAQENVKELKQLLSIATRDRKTQSKAEDGVLRKNFSFNLKELKFSNDTEDSDQTISHEDPEKAEALKGSIFDSSTDSPRSEPRSPRLVPHHRKESSSVFTDDGDTPMSEDLDHLDNSNFDDSDSDRNHRRRRTMFRRVGDLIMRKSFSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1U3</accession>
    <name>A0A068U1U3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00039887001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the HSF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1U3"/>
    <dbReference type="FunCoup" id="A0A068U1U3">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1U3"/>
    <dbReference type="Gramene" id="CDP02491">
        <property type="protein sequence ID" value="CDP02491"/>
        <property type="gene ID" value="GSCOC_T00039887001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1U3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1U3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000037">
        <property type="entry name" value="Heat stress transcription factor B-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF329">
        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR B-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="13">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP02491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="532" mass="58846" checksum="D1D510AA8DECBE1A" modified="2014-10-01" version="1">MCQRTVPAPFLTKTYQLVDDPCSDDVISWNESGTTFVVWKTAEFAKDLLPNYFKHNNFSSFVRQLNTYGFRKIVPDKWEFANDNFKRGRKELLTDIRRRKTTTSTQSTNQAGAGKSLTTANPTSPANSGEDLGSSSTSFPGSKSPGSVDTLSAEQFADLSDENEKLKKDNQMLSSELAQTKKQCDDLVAFLTKHVNVAPDQINSIMNQGAAVGEMNFNENNCVVDDRVDSKEADDDDDDENGNGGSLKLFGVTLLTEKNRKRGRDDMDVGYAEVRPRKDVKTLDFCAPWMRIASCAGETSKAAGQKARQNCGDSSSSPVSISGQRKMDSTETPLSTSPSHSNFSQQRHFYLAVDRLQFKMETLVDLLGMAGRQPCLRMVVCCSTRDELDAVCSAVSRLSYISIATLYSDQAEAERARILEKFRQTAINWNNCTADGEEKKDDKEERNKSHMIIVTDACLPLLGMGESPISSRVLINYELPTKKETYLRRMATCLATDGIVINMVVGGEVATLKSIEESSGLVIAEMPIHVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U200</accession>
    <name>A0A068U200_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039703001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U200"/>
    <dbReference type="FunCoup" id="A0A068U200">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U200"/>
    <dbReference type="Gramene" id="CDP02342">
        <property type="protein sequence ID" value="CDP02342"/>
        <property type="gene ID" value="GSCOC_T00039703001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U200"/>
    <dbReference type="OMA" id="WCWIAKK"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U200"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="36"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="173" mass="19505" checksum="3AD15C005F6D02D9" modified="2014-10-01" version="1">MRLVSLRSFQIPAIFSSGSRLMAQSAGSSGGKRLVQVDISSDTVCPWCFVGKKNLDKAIASSQDQYDFKIKWHPFFLNPSAPKEGVNKKEFYTNKFGSRSEQIVTRMTEIFKGLGMDYDMSGLTGNTLDSHRLLYLAGQQGLEEQHKLAEELFIGYFTQGKYIGDRQVQIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U261</accession>
    <name>A0A068U261_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039573001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U261"/>
    <dbReference type="FunCoup" id="A0A068U261">
        <property type="interactions" value="1743"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U261"/>
    <dbReference type="Gramene" id="CDP02239">
        <property type="protein sequence ID" value="CDP02239"/>
        <property type="gene ID" value="GSCOC_T00039573001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U261"/>
    <dbReference type="OMA" id="PANWEDN"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U261"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000006">
        <property type="entry name" value="Defective in cullin neddylation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="315" mass="35958" checksum="80C659AB231AFA23" modified="2014-10-01" version="1">MESSSFVPTRFDIFEIYRQYCAIMSRPYDSGSEGCLSNEEYQNGRYSRNALTQLLKLVDSRSQTRFSVFEEIYKLMMRLDLLADFSEFSRFYDFVFFICRENGQKNITVSRAVMAWRLVLAGRFQLLNQWCNFVEKNQRHNISADTWRQVLAFSRCVQDNLEGYDPEGAWPVLIDDFVEHMYRIGCNDTSYSLCSCGDSDERPFDDSLPGSKSLPGLKRKLGDNLQKEHESLNGYVHSNGARLPKRRQLISADILFNCDENCGSAADDCMETAKQNSALGCTKSPCSIEGCLSKGFAGLFSGRPYLQCNRHRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2L5</accession>
    <name>A0A068U2L5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040282001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068U2L5">
        <property type="interactions" value="2871"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2L5"/>
    <dbReference type="Gramene" id="CDP02785">
        <property type="protein sequence ID" value="CDP02785"/>
        <property type="gene ID" value="GSCOC_T00040282001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2L5"/>
    <dbReference type="OMA" id="ETNSICI"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2L5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010364">
        <property type="term" value="P:regulation of ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900055">
        <property type="term" value="P:regulation of leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005982">
        <property type="term" value="P:starch metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044218">
        <property type="entry name" value="SWEETIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46975">
        <property type="entry name" value="PROTEIN SWEETIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46975:SF2">
        <property type="entry name" value="PROTEIN SWEETIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1981"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2086"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2144"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2000"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2019"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2046"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2087"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2109"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2145"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2160"/>
            <end position="2172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2187" mass="240191" checksum="08B95D66054984CA" modified="2014-10-01" version="1">MARNYVRENVPLSRFGVLVAQLESIVASAAHKPPDPLLCFDLLSDLIAAIDEEPKESILLWQRKCEDALYSLLVLGARRPVRHLASVAMANIILKGDGISIYSRVSSLQGFLSDGKKSEPQRLAGAAQCLGELYRYFGRRITSGLYETTIIVTKLLKFNEDFVRQEALHMLQNALEGSGGNAAASAYTEAFRVITRIALGDKSFIVRKAAARCLKAFANIGGPGLGFAELENSSSHCVKALEDSVSSVRDSFAEALGSLLALGMNPNAQLQPRGKGHCSPTKLEGGLQRHLSLPFIKASGPRMKELRVGIALSWVSFLQAIRLRYLQPDSELQSFTVQVIDMLQTDDNTVDAQALACVLYILRVGVTDQMSEPTQRSFLVFLGKQLQSSDATPSMRIAALRTLSYTLKTLGEVPQEFKEVLDDTVVAALSHYSPLVRVEAALALRSLVEVDPSCVGGLISYAVTMLSAARENVSFEKGMNLKFELESLHGEAAVLAALVSISPKLPLGYPARLPRSILEVSKKMLMESSRNHVAAAVEKEAGWTLVASLLASIPREELEDQIFDVLSFWASLFNKNLDISQREDLSSSICVWSAAIEALTAFIKCFVSSDGVNNGILLEPVLLYLSRALSYVSLLAAKELANVKAETDILIIRILIAYQSLADPTAYKNDHPHIIQICTTPFRDASRCEESSCLRMLLDKRDAWLGPWTPGRDSFEDELRSFQGGKDGVLPCLWENDPPSFPQPETVSKMLVNQMLLCFGTMFASQDSSGMLSLLGMMEQCLKAGKKQSWRTASITNICVGLLSGLKALLALRPEPLGLEILTAAQSIFQSILAEGDILATQRRASSEGLGLLARLGNDIFAARLTKLLLSEVNGAADVHYSGSIALALGSIHRSAGGMALSSLVPATVNCISSLSKSAVTSLRMWALHGLLLTIEAAGLSYVSHVQATLTLSLDILLSEESGLVDLQQGVGRLINAIVAVLGPELSPGSIFFSRCKSVVAEISSCEETATLLESVRFTQQLVLFAPQAVTVHSHVQALLPTLSSRQPTLRHLALSTLRHLVEKDPASIIGEAIEDALFLMLDEETDTEIANLARTTIMRLLLASCPSFPSHWLSICRHMILTSSRRDAGSNNMDSDSITGPSGEEGSNFGEDDENMVSSPRSMPSQGHALDYSGANSARDKHLRYRTRIFAAECLSHLPGAVGNNPAHFDLSLARTITANSIASGDWLVLQLQELISLAYQISTIHFENMRPIGVALLSTIVDKFEKIADPELSGHLLLEQYQAQLLSAVRTALDTLSGPILLEAGLRLATKILTSGVISQDQAAVKRIFSLISRPLNEFNDLYYPSFAEWVSCKIKIRLLTAHASLKCYIYGFLRREKDRMPGEYQALLPLFSKSSDTLGLYWLSVLKDYSYIRFRLPPRKNWKAFLEGVQSSLVSSKLQPCLEEAWPVILQAVVLDAAPVKPFANGSSAAEDKSESDFISEYRMVELRAEEFHFLWGFSLLVLFQGQDTSSDQVVIPVGSVKSKFSADLTVEDGSSVTSRIYETILPVLQFLSIERFFSAGYLTMDVCRELLQVFLYSIVAGNSWDSLAVSVMLKILQNCPKDFLEKENFAYLSSELCLAFLFKFFASCDAASPYQLNWENTVLVSLSAAATLLRRVDRKMRLKLLFGFLLSGCKSIGAASTELSLSRVNDFVLSIISIVKGHVDKSELDSDGVCQLRTINHACLNASVSLINECVDSIHQMEDKRSNQRKLLQMRLAFSLEHVVSFAKVAFELESFGEGKENDPSLSTDLCHCNQCIQAVLSDYNIQVQVISLQVLKSMLQKSSDTCNSFEIFFVGELAGDLLIVIQKFLEKPIRESVTIVGECLKILMLFQALSRDSECQKGILSLLLEAIFMVFSASEENLSRDLNELRSTAIKLVSQLAQSPKSGVYFKDVLLTMPITRRQQLQDIIRASMKQEQNIIEKKPMVPPLAIKIPAQTEETKQQSSPSSLARESDDKSEEEDDDDDWDTFQSFPASTKEAASTSSITSEEPDSTKNPSIPIHDFEGHLRPRDSDEAKEVIVANDADAEAEAGGILDSAMVRNQVEEIHDPECDRRSTEQLDGLQPDSSKVISSQTRSEAVTSPVEVEEYKKACEMEKITIAPSTEESLSSPDFQNVEEHSHPDNEHHVSTSAGSCDKNELDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3P1</accession>
    <name>A0A068U3P1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039511001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3P1"/>
    <dbReference type="STRING" id="49390.A0A068U3P1"/>
    <dbReference type="Gramene" id="CDP02193">
        <property type="protein sequence ID" value="CDP02193"/>
        <property type="gene ID" value="GSCOC_T00039511001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3P1"/>
    <dbReference type="OrthoDB" id="1918850at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3P1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34468">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED FUTSCH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34468:SF3">
        <property type="entry name" value="OS03G0288900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="141" mass="16499" checksum="7AA34723F714DADE" modified="2014-10-01" version="1">MPYLRSRHPPVMLLTRQFSRPCDYDFTILALYWLDRIRLAESVGKHFVSAAFFRLATECKAEPFRNTKVELKKYLGQHEYLSGEKEWKDLFISYGLMKEESNLCHNNKEEEAIEDSDHPGNTRDEQEKQIMEPAAGEPGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3U7</accession>
    <name>A0A068U3U7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039636001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3U7"/>
    <dbReference type="FunCoup" id="A0A068U3U7">
        <property type="interactions" value="1092"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3U7"/>
    <dbReference type="Gramene" id="CDP02283">
        <property type="protein sequence ID" value="CDP02283"/>
        <property type="gene ID" value="GSCOC_T00039636001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3U7"/>
    <dbReference type="OMA" id="YRGNLRF"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3U7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46616:SF2">
        <property type="entry name" value="OS03G0211100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46616">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="261" mass="29311" checksum="56296E8F6DD7BA9D" modified="2014-10-01" version="1">MWNFASNCLAGRTKKDILRPAQDVMDSSDDDASSIASGEEGLECPICWESFNIVENVPYVLWCGHTLCKNCILGLQWAVVKFPPLPIQLPLFISCPWCNLLSLRLVYKGNLRFPRKNFFLLWMLESMNGDRVKSRSVFCGDQPQAWSSGGKATGNSSIRRAHYMHNSESSGTNHSNTRTNSYVAAERLCASLKKSLVFFVHLTAKFPLVVIFLLITLYAIPASAAILALYVLITVLFALPSFLILYFAYPSLDWLVREIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5U5</accession>
    <name>A0A068U5U5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00016363001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5U5"/>
    <dbReference type="FunCoup" id="A0A068U5U5">
        <property type="interactions" value="1599"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5U5"/>
    <dbReference type="Gramene" id="CDP03866">
        <property type="protein sequence ID" value="CDP03866"/>
        <property type="gene ID" value="GSCOC_T00016363001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5U5"/>
    <dbReference type="OMA" id="NAFMTEG"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5U5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044716">
        <property type="entry name" value="LEUNIG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376:SF22">
        <property type="entry name" value="TRANSCRIPTIONAL COREPRESSOR LEUNIG_HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF FILAMENTOUS GROWTH FLO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="664"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="746"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP03866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="84927" checksum="E9867E4E70CC7FFE" modified="2014-10-01" version="1">MAQSNWEADKMLDVYIHDYLLKRKLHNSAKAFMTEGKVATDPVAIDAPGGFLFEWWSVFWDIFIARTNEKHSEAAAAYIETQQMKAREHQQQLQLQQLQLMQQRNAQLQRRDPNHPPLGGSINALNSEGIMGQPSASVLAMKMYEERMKHPHSMDSDTSPALIDANRMALLKSATNHQGQLVQGNSGGMSAALQQMQGRPQLTADIKTEGSMGATQKSLPMDPSSIYGQAILQSKSGLGSAGLNQGVTGLPLKGWPLTGIEQLRPSLGLQVQKPNLQNQNQFLLASQQQQVLAQAPSQGSLGSSPNFGFGGLPRGNFNPKDGQPPRNDGSICSPVQSNSPKMKMTQMQQSSSQQQEQLQQQQQQQLQQSNRKRKQHSSSGPGNSTGTGNTVGPSPNSPPSTHTPGDGMTTSSSMQHVNSVPKSFMYGADGAGGIASPTNQLDDLENFGDVGPLEDNVESFLSHDGGDANIYGTLKQTLTEHKTESSKSFSFGEVGCIRTRNKVLCCHFSSDGKLLASAGHDKKAVLWNMHTLQTESTKEEHQYLITDVRFRPNSTQLATASFDKSVRLWDAANPSYCLQAYTGHASHILSLDFHPKKNDLFCFCDSNNEIRFWNTSPFSCAQISKQGGSAQVRFQPITGHLLAAASDKVVTIYDVENDRQTHSFQGHSGVVNYLCWDLNGDYLASVSEDSVKVWSLASGECIHELSSNGNQFHSCVFHPNYSALLVIGGLRSLELWNMVENKSMTVPAHENIIAALAQSPVTGMVASASHDSSVKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6M1</accession>
    <name>A0A068U6M1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Programmed cell death protein 4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041757001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6M1"/>
    <dbReference type="STRING" id="49390.A0A068U6M1"/>
    <dbReference type="Gramene" id="CDP03243">
        <property type="protein sequence ID" value="CDP03243"/>
        <property type="gene ID" value="GSCOC_T00041757001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6M1"/>
    <dbReference type="OMA" id="TWIGNGY"/>
    <dbReference type="OrthoDB" id="781057at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6M1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8452" checksum="18EADBA4CF3EE9BF" modified="2014-10-01" version="1">MRNSGKSSKTNVKAGNGQEIRRDRKSATGMNGSPKKGGHGGKFTWSGDGYSDVELGRIPKEALDVNDPNYEDPIKNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7F5</accession>
    <name>A0A068U7F5_COFCA</name>
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        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP04177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7F5"/>
    <dbReference type="Gramene" id="CDP04177">
        <property type="protein sequence ID" value="CDP04177"/>
        <property type="gene ID" value="GSCOC_T00017489001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7F5"/>
    <dbReference type="OMA" id="AKYWMYM"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657401" description="ER membrane protein complex subunit 10" evidence="10">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="304" mass="33523" checksum="0BAA5964A6058A41" modified="2014-10-01" version="1">MKITVYSPKSSSWILLLLTLSFLLTSSFAFQSDELLVDDEEFGLEGGSGSTPDVGSTIPARPSQPARKRSPDFSSGSDLDSKVQFTLEHAFGDSDFSPAGTFAARVKNSPHSGQTLTKLRFSRTDFTAADKDNFKKLLEADDFYRIRIPSNLLTSPGRDYVISSVKARCLPRHGLDEHIVIHMDGVNVLAVNYGSQGACQYPRHLKFPKRWLFNSHTVLKSGEQAPRTPVFSEETAVGENGEGEGVAPPERSFWAKYWMYLLPLGLIVMNAMTQAMNMPEEQQGGGQAGSQVQQRGQSAAVRRR</sequence>
</entry>
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            <taxon>Rubiaceae</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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                <person name="Lepelley M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
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    </reference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7U8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="8825" checksum="890399EEB14C6976" modified="2014-10-01" version="1">MDKRSSWWSFNSGHKTTDQYTGSSLFPGLQSCSGCIDQHQTLRLLNLLFLRSWNCWSCIECHSLLVPVLLGLIFCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U816</accession>
    <name>A0A068U816_COFCA</name>
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            <fullName evidence="1">F-box domain-containing protein</fullName>
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    <reference evidence="3" key="1">
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        <property type="component" value="Chromosome I"/>
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    <dbReference type="CDD" id="cd22152">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47850">
        <property type="entry name" value="F-BOX/KELCH-REPEAT PROTEIN OR23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47850:SF1">
        <property type="entry name" value="F-BOX_KELCH-REPEAT PROTEIN OR23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="417" mass="46718" checksum="4A76918D1487749C" modified="2014-10-01" version="1">MAPPYSWMSTEEVQLQTLTLTLIPGLPNDLASLILAFIPYSHQSRLKSVSKSWKLFLSSGTLISLRQSLLPSSARSHLLCIFPQDPSISSPYLFDPKNLAWRELPAMPCNPHAYGLCNFTSISVGPHLYVIGGSLFDTRSFPLDRPCSSSSTFRFNFLNWKWESLSSMLSPRGSFACAVIPNSNKIVVAGGGSRHPMYGAAGSRMSSVEMYDIGKDEWVPLDGLPRFRAGCVGFFVGNGEEKEFWVMGGYGECRTISGVFPVDEYYKDAVVMELKSGGKWREVGDMWEEGERRMLGKIVVLEGDGWHVPAIFMLDRGDIFRYDMASNQWLKETSVPRKASDESSVGFVALDGELHVLTLLDGIKLPDTRKLRRNKRSAALLLQIYHPKKERWRSVITKPPFNRPLNFRMAVICAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8L3</accession>
    <name>A0A068U8L3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017956001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8L3"/>
    <dbReference type="FunCoup" id="A0A068U8L3">
        <property type="interactions" value="1514"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8L3"/>
    <dbReference type="Gramene" id="CDP04529">
        <property type="protein sequence ID" value="CDP04529"/>
        <property type="gene ID" value="GSCOC_T00017956001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8L3"/>
    <dbReference type="OMA" id="HEYKFMV"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8L3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043554">
        <property type="entry name" value="KINB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46316">
        <property type="entry name" value="SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46316:SF2">
        <property type="entry name" value="SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="2">
        <location>
            <begin position="130"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="221" mass="25388" checksum="118A81AEE3403FF9" modified="2014-10-01" version="1">MPVVPLQRPDEMHIPSPSWMQTMSGHDDMYYEQGIPTMITWSYDGNEVAVEGSWDNWKTRTLLERSGKDFTIMKVLPSGVYQYRFIVDGQWKYLPDMPWIHDEAGNPCNILDLQDYVPEDIESISGFEPPQSPESSYNNLQLVAEDYAKEPPLVPPHLQMTLLNVPSAHMEIPPPFSRPQHVVLNHLYMQKGRSPSVVALGSTHRFLSKYVTVVLYKSIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U909</accession>
    <name>A0A068U909_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00019962001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U909"/>
    <dbReference type="FunCoup" id="A0A068U909">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05045">
        <property type="protein sequence ID" value="CDP05045"/>
        <property type="gene ID" value="GSCOC_T00019962001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U909"/>
    <dbReference type="OMA" id="HAKIAYR"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U909"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="102" mass="11681" checksum="27CB8F8A79D99072" modified="2014-10-01" version="1">MDVIPSDETTVDTVLTKWDFSCDLEVNYESERKVRIVYSALDVDKELQPDKVKREMSVSDGKLFVHFEAVEPRFLRASFSAFVDVLTLATKTIDEFDQGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB61</accession>
    <name>A0A068UB61_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00019687001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB61"/>
    <dbReference type="FunCoup" id="A0A068UB61">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04888">
        <property type="protein sequence ID" value="CDP04888"/>
        <property type="gene ID" value="GSCOC_T00019687001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB61"/>
    <dbReference type="OMA" id="FAWRPGH"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF16">
        <property type="entry name" value="TRANSPORT_GOLGI ORGANIZATION-LIKE PROTEIN (DUF833)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="257" mass="28900" checksum="7F21C8E2F735F6F4" modified="2014-10-01" version="1">MCIAVFIWEVHPLSIPPASQSGRISQSPNHPSGLDGRLAFLTNVRELVHPSSPHQQPKSRGYLPLRFLQSKKSPEEFADELLEEATLYNGFNLIVADLCSMSMLYITNRPKGSGIIATQVSPGIHVLSNAKLDSPWPKVVCSKIGQSFKDLMDKYGEGEIPLKEMSEKLMNDTTKDDESKLPQIYPPEWEYHSSSIFVDADMPMGRYGTRSTSALAMSTSGNITYFEKHLDADLWKEQIISFQIRREEMTLSSFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDV7</accession>
    <name>A0A068UDV7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroflavonol 4-reductase</fullName>
            <ecNumber evidence="8">1.1.1.219</ecNumber>
            <ecNumber evidence="7">1.1.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydrokaempferol 4-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Flavanone 4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00021104001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme involved in flavonoid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11228"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15605"/>
            <dbReference type="ChEBI" id="CHEBI:15606"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54444"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138176"/>
            <dbReference type="ChEBI" id="CHEBI:138188"/>
            <dbReference type="EC" id="1.1.1.219"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pigment biosynthesis; anthocyanin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.219" evidence="8"/>
    <dbReference type="EC" id="1.1.1.234" evidence="7"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDV7"/>
    <dbReference type="FunCoup" id="A0A068UDV7">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDV7"/>
    <dbReference type="Gramene" id="CDP05813">
        <property type="protein sequence ID" value="CDP05813"/>
        <property type="gene ID" value="GSCOC_T00021104001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDV7"/>
    <dbReference type="OMA" id="AHIQDVC"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDV7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045552">
        <property type="term" value="F:dihydroflavanol 4-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047890">
        <property type="term" value="F:flavanone 4-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009813">
        <property type="term" value="P:flavonoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08958">
        <property type="entry name" value="FR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF628">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0284">Flavonoid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP05813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="355" mass="39263" checksum="10FF0BDC6E17C93C" modified="2014-10-01" version="1">MEDIAAREEGRSQEESPVTYCVTGASGYIGSWLVKSLLQRGYRVHATVRSPEKSLNLLKEWDGGERLRIFKADLQEDGSFDAAVRGCSGLFHVAASMQFEVPVEENVDSYVQTNVIEPAIKGTLNVLKACSRTNSVRRVVFTSSISTMTAKDSLENWRDLVDESCKVPINRVWKHKPTGWVYALTKILTEEAAFQFAHENGIDLRSVITATVAGPFLASTVPTSLRVLLSPITGDPQLLPILVGVNSRMGSIALVHIEDICNAHIFVMEDARAEGRYMCCSRSCGMAELVDYLMEEYPCSNLQRLVKAKNESIPAEISSKKLTDLGFNFKYDVQDIIQQAVEKCIACGFLPGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE28</accession>
    <name>A0A068UE28_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NusG-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00023419001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE28"/>
    <dbReference type="FunCoup" id="A0A068UE28">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UE28"/>
    <dbReference type="Gramene" id="CDP06532">
        <property type="protein sequence ID" value="CDP06532"/>
        <property type="gene ID" value="GSCOC_T00023419001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE28"/>
    <dbReference type="OMA" id="CILNKEI"/>
    <dbReference type="OrthoDB" id="8300383at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE28"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06091">
        <property type="entry name" value="KOW_NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09890">
        <property type="entry name" value="NGN_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF4">
        <property type="entry name" value="KOW MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="RHO-INTERACTING TRANSCRIPTION TERMINATION FACTOR NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="N-utilization substance G protein NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP06532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38876" checksum="D2C68AA4420C7DDA" modified="2014-10-01" version="1">MIELQRRLLTWSPCPLFLSPSTHYSKAFNKLRSPIISFTISATVEAVTEKQPTARERRQLRNERRESKPAYNWREEVEERLVKKPKKRHASWTEELNLDNLALLGPQWWVVRVSRVSGQDTADRLARALARNFPALDFKVYVPSVQIKKKLKNGSISVKPKALFPGCVFLRCVLNKDVHDFIRECDGVGGFVGSKVGNTKRQINKPRPVDAEDIEAIYKQAKEEQDKADQAFLEEHEGHRTSDFEKLNLDALPASLDDVESNTSVEAQGRSRKTTKPPLGFQLGGSGFKLLVPGSKVQVVSGAFAGFSGILKKFNKKKALATVSFTLFGKETLADLDVKEIVAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEL2</accession>
    <name>A0A068UEL2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Vacuolar protein sorting-associated protein 41 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00024090001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEL2"/>
    <dbReference type="FunCoup" id="A0A068UEL2">
        <property type="interactions" value="3035"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEL2"/>
    <dbReference type="Gramene" id="CDP07010">
        <property type="protein sequence ID" value="CDP07010"/>
        <property type="gene ID" value="GSCOC_T00024090001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEL2"/>
    <dbReference type="OMA" id="PQLVWQD"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEL2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16687">
        <property type="entry name" value="RING-H2_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000545">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000554">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057779">
        <property type="entry name" value="Znf_RING_Vps41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23555">
        <property type="entry name" value="zf-RING_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="11">
        <location>
            <begin position="43"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="612"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 C-terminal RING finger" evidence="12">
        <location>
            <begin position="872"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP07010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="957" mass="107558" checksum="E550EF5443FF2633" modified="2014-10-01" version="1">MAAKPSENGVEGDDEREEEEEEEEDSEEVEDGEEEEEEEEPRLKYQRMGGSVPSLLSSDAASCIAVAERMIALGTHAGLVYILDFLGNQVKEFPAHTAAVNDLCFDIEGEFVGSCSDDGSVVINCVFSDERLKFDYHRPMKAIALDPDYSRKSSRRFVAGGLAGHLYFNVKKWIGFRDQVLHSGEGPIHAVKWRSSLIAWANDAGVKVYDSANDQRITFIERPRGSPRAEILRPHLVWQDDTLLVIGWGTYVKIASIRANENKGINGAYRHIPMSSINQVDIVASFQTTYFISGLAPFGDTLVVLAYIPGKEDGENEFSSSVPSRQGNAQRPEVRVVTWNNDELATDALPVHGYEHYKAKDYSLAHAPFSGSSYAGGQWAAGDEPLYYIVSPKDVVIAKPRDTEDHISWLLQHGWHEKALAAVEAGQGRSELLDEVGTRYLDHLIVERKYAEAASLCPKLLRGSASAWERWVFHFAHLRQLPVLVPYIPTENPRLRDTVYEVALVALATNPSFHKDLLSTVKSWPPVIYSASPVISAIESQLNTSSATDPLKEALAELYVIDGQYEKAFSLYADTMKPDIFDFIEKHNLHDSIREKVAQLMMIDCKRATSSLIQHINLIPPPDVVSQLIAARDKCDWRYFLHLYLDSLFVANPVTGRDYHDMQVELYADYDPKMLLPFLRSSQHYTLETAYEICAQRGLLRQQVFILGRMGNSKQALALIINNLGDIEEAVEFVSMQHDDELWEELIKQCLDKPEMVGVLLEHTVGNLDPLHIVSMLPDGLEIPRLRDRLVKIITDYRTETSLRHGCNDILKADCVNLLIKYYKEARRAIYFSNEENEIRAKRDETKASYLGERVAGMKSMEVKSKTRGGARCCMCFDPFPIQEASIVAFFCCHAYHTTCLMESLNSVTSKKEPKTSPKEVLAYYEYENGDVDEDEDDASSSGAPQMRCILCTTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UF49</accession>
    <name>A0A068UF49_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022920001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UF49"/>
    <dbReference type="STRING" id="49390.A0A068UF49"/>
    <dbReference type="Gramene" id="CDP06223">
        <property type="protein sequence ID" value="CDP06223"/>
        <property type="gene ID" value="GSCOC_T00022920001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UF49"/>
    <dbReference type="OMA" id="HVETICC"/>
    <dbReference type="PhylomeDB" id="A0A068UF49"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="208" mass="23616" checksum="DF332DAA1B36F72E" modified="2014-10-01" version="1">MLILLVRSLEPKGHVETICCSPLYMALEIMQPQKYDAKLIVFFIIFSVSYLIYCILPFSNLLLTFLQLIQNIMRSTDLQFPRDLKDLNPHCIDLCQKLLRRNPSTRLTFEEFFNADELLNMRAQKIIHSFPLFELNPVGKIEEIAQQDLPSSLDDDSSGLDGSPSFVGMSPIKSTYGFSLDTKADRKEVSKAAEKKDLASNYGVSVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG10</accession>
    <name>A0A068UG10_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00024684001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG10"/>
    <dbReference type="FunCoup" id="A0A068UG10">
        <property type="interactions" value="1691"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG10"/>
    <dbReference type="Gramene" id="CDP07421">
        <property type="protein sequence ID" value="CDP07421"/>
        <property type="gene ID" value="GSCOC_T00024684001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG10"/>
    <dbReference type="OMA" id="NFYCAND"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG10"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053223">
        <property type="entry name" value="Prob_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44067:SF3">
        <property type="entry name" value="OS06G0138600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44067">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46869" checksum="8D092A9307CC30D0" modified="2014-10-01" version="1">MGSVSLKIGDGTARFKRASLCSSAVNVLMLFSVITTNLFALYAFTYSPKDPLTTHSIHHTQKNISLISEQVSLILREIESSQKKLAQMEKELLGYESIDLSRPNTASELKVFLQHHLLPLGKDSRTGITEMVASVGHSCEKSVDLLSQYMNYKVSGPCPDDWSLGQKLILRGCEPLPRRRCFAKTIPKVGLQPFPISLWKDVSEKVYSWSGFTCKNLACLNSKKLNRDCAGCFDIVNGYETQKYIKARGKNDFLIDDVLALGSGGIRIGFDIGGGSGTFAARMAERNVTLVTATLNIDAPFNEFIAARGLFPVFLSLDHRFPFYDNVFDLIHAANKLDVGGRPEKLEFLMFDIDRILRAGGLLWLDNFYCSNDDKKRALTRIIEQFGYKKLKWVVGEKINGSGKAEVYLSAVLQKPVRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIR5</accession>
    <name>A0A068UIR5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00027172001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIR5"/>
    <dbReference type="FunCoup" id="A0A068UIR5">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIR5"/>
    <dbReference type="Gramene" id="CDP08366">
        <property type="protein sequence ID" value="CDP08366"/>
        <property type="gene ID" value="GSCOC_T00027172001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIR5"/>
    <dbReference type="OMA" id="SNQFRHA"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8243" checksum="47AD70CA19522E8D" modified="2014-10-01" version="1">MAKPLGPTGEFFRRRDEWRKHPMLTNQFRYAIPGLGIALVAFGIYLVGEAAYSKIYATSHSHSHASSSAAGSHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKX2</accession>
    <name>A0A068UKX2_COFCA</name>
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        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028018001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKX2"/>
    <dbReference type="STRING" id="49390.A0A068UKX2"/>
    <dbReference type="Gramene" id="CDP08889">
        <property type="protein sequence ID" value="CDP08889"/>
        <property type="gene ID" value="GSCOC_T00028018001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKX2"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKX2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="70" mass="8105" checksum="21E69A9CA42CC6D9" modified="2014-10-01" version="1">MRPIFCGNLEFDARQSDVERLFRKYGKVERVDMKSGLLGLSMIFLDGWFSASLFWLVPKIHVNVFPKGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL63</accession>
    <name>A0A068UL63_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028513001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL63"/>
    <dbReference type="STRING" id="49390.A0A068UL63"/>
    <dbReference type="Gramene" id="CDP09260">
        <property type="protein sequence ID" value="CDP09260"/>
        <property type="gene ID" value="GSCOC_T00028513001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL63"/>
    <dbReference type="PhylomeDB" id="A0A068UL63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061927">
        <property type="term" value="C:TOC-TIC supercomplex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045037">
        <property type="term" value="P:protein import into chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031610">
        <property type="entry name" value="TIC110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935:SF3">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16940">
        <property type="entry name" value="Tic110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="202" mass="21368" checksum="850EE20E6A109D7E" modified="2014-10-01" version="1">MDTSIFLTVRPSVAQPKVLFSPFLPPNPLRLSTTPAYHQSRRRRRYRIPTIRSASIPTSLSASSSSDQPIKAIEPDVFGGKKELTGFQALVDAMSPTVRIASSALIFAGAIAAGYGLGSKFGGSRNVAMGGAVALGTAGAGVAYALNSCVPEVAAVNLHNYVADFDDPAALNKEDVEAIANRYGISKQNEAFNAELCDIYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL99</accession>
    <name>A0A068UL99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00028424001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL99"/>
    <dbReference type="STRING" id="49390.A0A068UL99"/>
    <dbReference type="Gramene" id="CDP09196">
        <property type="protein sequence ID" value="CDP09196"/>
        <property type="gene ID" value="GSCOC_T00028424001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL99"/>
    <dbReference type="OMA" id="RVQCYQN"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000569">
        <property type="entry name" value="Serine/threonine-protein kinase-like protein CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655009" description="non-specific serine/threonine protein kinase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="495"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP09196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="795" mass="85814" checksum="C72C57AB443AFD47" modified="2014-10-01" version="1">MNSPAFPSTTITLLIIIILTTCCQHGVTSLGSGSTIAVSYTSSDSTNTVCGIIASKLTQRIQCYKNCQTISIQPEISYESISGGLGYFCGLQSGGLSIICWDTMSFRAKRIYYSKYNRLKGLSVGNYQVCALQFTTGAALCWRIPSPEEGTKFRAITSGEGFSCGILKNAGRVHCWGRSEIGAEIEIQFKSLPMLNLIAGESHACGVTKAGTLICKGSNIGGQLNVPSHYAFEFSSLALGANHSCGIRKKNGLVVCWGGGSRKLEFSSNVVDEVSFENIVAGLDFTCGLTTKDLSIICWGPGWSRNLTAGDVVLLEPVLPGPCMQMSCRVCGVYPNSGSLCAGSGSICKVCEVELPIPVNLPPLMPSTPGSQVPEIASSPSRTKNRLFLAFGVVGCIGAFAGICTIAYCFCAGLCGNEHKNVYKPVVLQPTSARSNLEDYLAASNASILPPSGSSSIKRNNSWVLRSQRSGTSSRQTERTENFTLSELAAITSNFAQENKIGGGSFGRVYKGKLADGREVAIKRAECSSKTKKFQEKESSFLSEIALLSCLNHKHLVGLVGFCQENDERLLVYEYMRHGSLHDHLHGQRNTDSSMLNSWRMRIRIALDAARGIEYLHNYSIPPIIHRDIKSSNILLDGNWTARVSDFGLSLMWPESEDEPMYMKAVGTVGYIDPECYVLNILTVKSDVYGFGVVLLELLTGKKAVFTNEGAGPMGVVEYARPWIVAGELEKILDKRVGLPEMNEIEAAEVVAYTALHCTSLQGKDRPTVSDVVAKLERALALCDDSSAIVIASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNN4</accession>
    <name>A0A068UNN4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030343001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNN4"/>
    <dbReference type="STRING" id="49390.A0A068UNN4"/>
    <dbReference type="Gramene" id="CDP09864">
        <property type="protein sequence ID" value="CDP09864"/>
        <property type="gene ID" value="GSCOC_T00030343001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNN4"/>
    <dbReference type="OMA" id="CGAMEPV"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="504" mass="54854" checksum="6423A06ECE7438FC" modified="2014-10-01" version="1">MASKPEENTADKLHLEPCSPSSPKERWSGNMVSLILSELKLQRGITVPMLAMNFTWFARIAVTTAFLGRLGELSLAGGTLGATFSNVTGFAVLNGLCCAMEPICGQAFGAKNFKLLHKTLVMAIIVLLVASIPISILWLNVDKILIQFGQQEEISVAVRKYLLYLLPDLVVYSFLGPLKSYLSTQSLAVPIMLSSAFGLGFHVPITMLLSRARGFEGVSMAVWMSDLVVVVLLAFYVLIAEHGKRGNWNGGGWWEQGIHDWKRLLKLCGPCCITTCLEWWCYEILMLLTGRLPNAKQAIGILAIVMNFDYLLYSVMISLSTSASVRISNELGANQVGPAYRSAYISVGISVISGIIGASVMVSARDSWGGLFSHEKGITSNVKKMLLIMAVTEVFNFPLVVCGGIVRGTARPKLAMYANITGFYLFALPVGAVLAFKIHLGLPGILIGFLSGCIACLVLLVVFIARIDWKDEARKARSLTSSPVEEEIKDHEDHKNSGVNNVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPH7</accession>
    <name>A0A068UPH7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00031036001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPH7"/>
    <dbReference type="STRING" id="49390.A0A068UPH7"/>
    <dbReference type="Gramene" id="CDP10336">
        <property type="protein sequence ID" value="CDP10336"/>
        <property type="gene ID" value="GSCOC_T00031036001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPH7"/>
    <dbReference type="OMA" id="EMLFFET"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="226" mass="25207" checksum="566FC857A5D83B11" modified="2014-10-01" version="1">MDSSDEEGEEYLFKIVIIGDSAVGKSNLLSRYARNEFNPHSKATIGVEFQTQSLEIDGKEVKAQIWDTAGQERFRAVTSAYYRGAFGALLVYDISRRTTFESIPRWLDELKTHSDTTVARMLVGNKCDLENIRDVSVEEGKSLAESEGLFFMETSALDSTNTSALDSTNVITAFEMVIREIYNNVSRKVLNSDSYKAELSVNRISLVNDGSDGTKQTQGLYSCCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URD8</accession>
    <name>A0A068URD8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032009001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URD8"/>
    <dbReference type="FunCoup" id="A0A068URD8">
        <property type="interactions" value="1094"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URD8"/>
    <dbReference type="Gramene" id="CDP11001">
        <property type="protein sequence ID" value="CDP11001"/>
        <property type="gene ID" value="GSCOC_T00032009001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URD8"/>
    <dbReference type="OMA" id="GEYYHED"/>
    <dbReference type="OrthoDB" id="68076at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF28">
        <property type="entry name" value="YEMANUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="817" mass="88396" checksum="93DF318291643EF7" modified="2014-10-01" version="1">MDEVGGGGGSAGGAGGSESGGGGGGGGRSGTTSVEVGGERLRFRVELRPGETTIVSWKKLLKDANAHGHGAAAAAAAMGSSSTAAGASASASKPNGPGPGPDPAAPSSFSTQVNNHDNIPGPPPPPHPPSMDPRLAPVSFSGGQVGEKGETDAPQPPNRLNTVIERIERLYVGRASSDEEDLNDVVPDDDEYDTEDSFIDDTELDEYFQVDNSAIKHDGFFVNRGKLERVEPSMLPNEQPKKRRRKDGKGLDGSDDALNPGKHLKAGKKAGKPVPMFGRNASGLPTVIALPNVHGEDLKFQNQVNALEVSSKKRSHDSGEQPPLGVMNGDAVTLGKVSEQQKLGTHLANNQGNQMKEGCEYSDTSNQRSQEKTSYSQSKPLPGKALNNAALDQSIPQKEKSGIRERSEVGVADSKNSMQNVRVSYMQKREGSSARPKSTLLEKAIRDLEKMVAESRPPTAEAQDADNSSQGVKRRLPPEIKQKLAKVARLAQASHGKISKELVNRLMSIVGHLIQLRTLKRNLKIMVSMGLSAKQEKDNRVQLVKKEVAEMIKMRIPFMKSKAAEQQAGTSDDFQEISAEEKEAFKRKYSLDDALEDKICDLYDLYIEGLEEDAGPQVRKLYAELTALWPSGFMDNHGIKRAIYRAKDRRRALYGRHKDPEKIKRKKMLARKTEAARMEVHTVAQPVYIQEKSVADSSDHGTVLVNRPASSNTVAGAAVRMPVNFLNGSNVDRPKQEKIKGSASAHPDAIASEILQSKKIKRKPETELGDAAQFRPEKLLSVQGDDKNKSHKVQVAGSLPKSNPHPTGPTNFEQHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URZ3</accession>
    <name>A0A068URZ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GSCOC_T00033445001</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URZ3"/>
    <dbReference type="SMR" id="A0A068URZ3"/>
    <dbReference type="STRING" id="49390.A0A068URZ3"/>
    <dbReference type="Gramene" id="CDP11295">
        <property type="protein sequence ID" value="CDP11295"/>
        <property type="gene ID" value="GSCOC_T00033445001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URZ3"/>
    <dbReference type="OMA" id="PYLEYLY"/>
    <dbReference type="PhylomeDB" id="A0A068URZ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF771">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655171" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="24"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="844"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDP11295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1131" mass="124827" checksum="78E4AEA78BC0594B" modified="2014-10-01" version="1">MEKFHHLSPLGLVLLCFLSASFAVFPSNITTDKSSLLALRAHISVDPLQILAKNWSVGSSVCEWIGVTCGSRHHRVTALNIANLGLVGIIPPQLGNLSFLVSLDMSANNFHGELPHEFVGLRRLKLFNLSVNNLEGELPWWIGSFPQLLRLSLSNNSFTGLIPSSISNMSKLEEISLSYNLLQGNIPTGIFNISSLQLMRLTGNGLSGTIPSDMCHHLRGLSLLALSQNKLNGQLPSSLGQCSELQTLSLSFNGFRGSIPKEIGDLKKLEVLFLSHNYLEGKILANFFTIDKLRAKTYSCQIPKEIGNSTMIKMQNFGFNNLTGTTIFSMTEIRHLHDLIYVLNIILAGVIPREIGNWYFLQQLSLQFNSLTGSIPMEIFNLSKLRIMSVTQNQLSGNLPSTFPYLEYLYLGNNHLSGALPSSISNSSNLHLIEIADNKFTGPIPTSMGDLRFLELLDLSGNLLVRDFPSPELSFITSLAKCKYLAILFLGGNPLNGIIPNSLSNLSTSLEQLNAPNCKIKGSIPDGIGNLTSLILLDLSNNDLTGSLPATIKDLRKLQYMDLSMNKLISRVPLHLLCALHNLDTMNLGQNQFMASIPKCFGNLTSLRHLNLSHNRLYSAPPEEIWNLKDLLELDLSSNLLSGSLPYAITNMKMANWVDLSTNQFSGGIPGSIGDMQNLQNLSLAHNRLQGSIPESIGKVFSLESLDLSHNFLSESIPISMENLRYLKNINLSFNNLSGEIPSKGPFTNCTAESFASNEALCGAQRFHVPPCPSFSAHKLRIKKLHRTIFISLGVIIAVGALSFGFVYLRYQKKDEFSSGADLSLVAMPERISYFELLQATNGYNESNLLGTGSFGSVYRGTLDDGRAVAIKVFNLQVDGVFKSFDVECEVLRNLRHGNLTRVISSCSNPDFKALVLEFMPNGSLEKWLYSHNCFLDLMQRLDILIDVACALQYLHCEYATPVIHCDLKPSNVLLDQDMVAHLSDFGLTKLLGEKNSITYTETLATLRYLAPEYGLEGLVSAKCDIYSFGIMIMEVFTRTNPNSEMFGEKLSLKSWVANSIPDRLANVIDANLLKKSDKCIGEKLSCIASIMKVALGCTMESPKERSNIQDVLVAMKKIKLQYTSPLYSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV00</accession>
    <name>A0A068UV00_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00033728001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV00"/>
    <dbReference type="FunCoup" id="A0A068UV00">
        <property type="interactions" value="1203"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UV00"/>
    <dbReference type="Gramene" id="CDP11463">
        <property type="protein sequence ID" value="CDP11463"/>
        <property type="gene ID" value="GSCOC_T00033728001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV00"/>
    <dbReference type="OMA" id="WTHYNAG"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV00"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000199">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009251">
        <property type="entry name" value="PRK12607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="11">
        <location>
            <begin position="110"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="409" mass="45853" checksum="C48A3432B6237DCF" modified="2014-10-01" version="1">MAQNCIGGALNPPKILTPKCIPISHPNPSSLSSSSLRKFILTKSKKYLPPSICISASMSSSQQHQPPLSLEALKTSERRNEVLNAIQSSLSNCLSVTHLDLTVPGLKSKTRGKVRDIYDGGNYLVLVTTDRQSAFDRVLASIPFKGQVLNETSLWWFNKTQHIVPNAVVSAPDKNVTIAKKCSVFPVEFVVRGYVTGSTDTSLWTVYKKGVRNYCGNVLPDGMVKNQKLPENILTPTTKAADHDVPVTPDEIIQRGLMSRADYEEASKRALQLFQYGQQVAMKHGLVLVDTKYEFGKAPDGTVLLVDEVHTPDSSRYWIGHSYQERFWNGLEPENVDKEFLRLWFNDHCNPYEDKVLPDAPEELVSELAWRYIFLFETITNSSFEIPTTKEPIHDRITQNVSQALKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVT1</accession>
    <name>A0A068UVT1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00036348001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVT1"/>
    <dbReference type="STRING" id="49390.A0A068UVT1"/>
    <dbReference type="Gramene" id="CDP12645">
        <property type="protein sequence ID" value="CDP12645"/>
        <property type="gene ID" value="GSCOC_T00036348001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVT1"/>
    <dbReference type="OMA" id="MIRACYS"/>
    <dbReference type="OrthoDB" id="195057at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVT1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412:SF0">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41123" checksum="7B28BE71964C87C4" modified="2014-10-01" version="1">MGTLAGYSSSFSTIIFRCPLKNPLMEYAYRNRIPLVNGSAGSCNVLCREIIRKRRRISSRYFGKLMMIRACYSNNDDNSGSGEGEDKESSSLATAAKEDTEERRNGGGEDLDSEDFPGSVSSRQPTISPVGSGYNNFQVDSFKLMELLGPERVDPMDVKIIKEKLFGYSTFWVTKEEPFGDLGEGILFLGNLRGKREEVFAKLQNQLSEVMGDKYNLFMVEEPNSEGPDPRGGPRVSFGMLRKEVSEPGPTTLWQYVIALLLFLLTIGSSVELGIASQINRLPPEIAKYFTDPNAVEPPDMQLLLPFVDSALPLAYGVLGVQLFHEVGHFLAAFPKKVKLSIPYFIPNITLGSFGAITQASISSHPFLHFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVY6</accession>
    <name>A0A068UVY6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00036056001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739150">
        <property type="protein sequence ID" value="CDP12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVY6"/>
    <dbReference type="FunCoup" id="A0A068UVY6">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVY6"/>
    <dbReference type="Gramene" id="CDP12472">
        <property type="protein sequence ID" value="CDP12472"/>
        <property type="gene ID" value="GSCOC_T00036056001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVY6"/>
    <dbReference type="OMA" id="LYDCKGF"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVY6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 76, SUBFAMILY C, POLYPEPTIDE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47950:SF13">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 76, SUBFAMILY G, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658293" description="Cytochrome P450" evidence="9">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59872" checksum="6594F700943747E0" modified="2014-10-01" version="1">MVSKTSIGLVLLVVALLLLVAWAILTWQKCNASEKLERLPPGPRRWSVVGNMFQLGWSGHESFAILASKQGPIMTLWLGSMCTVVISSNEVAREMFKNHDVVLVGRKIYEAMEGDIGNEGTLITAQYGPRWRMLRRLCTAKFFCLEKIISNGYIKLEKLHLVARFCLTCEKIFKMTSLMNCSILNLVSNAINHSQFGLMQQLIIDQMVKYIEAAGGSGANGIDVGKFFFLLAFNLIGNLMFSKDLLDPSSERGAKFFDIAGLYLIERIIESNRDETDHPSPEKRRRDYLDVLLHYQGESAEEPPEFSPTTINIIVFRKTLCFLSNIKFGSYHVINLRTHEMFTVGTDMTTSILEWAMAELLRNPKTLEKVQAELRSAICLGTKLEEKHLDNLSYLKVVVKETLRLHPPLPFLVPHMAMDSKYLGIGRDPKTWENPLEFKPERFLEPSTADFQGHHFEFIPFGSGRRICPAVSLASMVRHLLPMALGSILHLFDWSLADGIKPEELDMGERMGITLRKAVPLKAILVPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UW99</accession>
    <name>A0A068UW99_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00036177001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739151">
        <property type="protein sequence ID" value="CDP12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UW99"/>
    <dbReference type="STRING" id="49390.A0A068UW99"/>
    <dbReference type="Gramene" id="CDP12549">
        <property type="protein sequence ID" value="CDP12549"/>
        <property type="gene ID" value="GSCOC_T00036177001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UW99"/>
    <dbReference type="OMA" id="HIAYPLM"/>
    <dbReference type="OrthoDB" id="605328at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UW99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055290">
        <property type="entry name" value="At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006527">
        <property type="entry name" value="F-box-assoc_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546:SF117">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546">
        <property type="entry name" value="F-BOX PROTEIN INTERACTION DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07734">
        <property type="entry name" value="FBA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="455" mass="51691" checksum="A96BE7C2D5A63DFF" modified="2014-10-01" version="1">MFPDEGGSPATDPLAGHPFEAEETLLRSSTAWPLAGKSRFSLSPDSSNTLKNPPQDCSHISAAGIVVAHNEDLLTQILLCLPPKSLIRFQCVSRGWLSIISNPSFRRLYCGSSNTRALILFRKIWRKCPELNFISFSDEYASSMETAISHLSSNFFTEGEITDLHSCNGLVAVVLKLSNGSREFAVYNPTTSQHRLIPQLNLLENRHPFVALNIAFDPLKSDHYKLVCVWLGPPTMRIMNVNYGFSIYESETGTWRDSGDIFEIDFAHSPTHFRNGVLWNGCLNWITHWKDIVCFDLDKEDVNFTLPSPPVSMKHSEIWYFGESVGCMYFIDINNPGEMLFDVFELASGCSEWVLKYHLNLAPLTILYPSMVDEEFNHSDDWRCRFSFTYFVEDENEKKARLVISLLGKVILYDIDDMVVEVLAEVGPTDTDDDCRDNLNEWRDAYPIMKTLACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXI0</accession>
    <name>A0A068UXI0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poor homologous synapsis 1 PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038072001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXI0"/>
    <dbReference type="FunCoup" id="A0A068UXI0">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXI0"/>
    <dbReference type="Gramene" id="CDP13205">
        <property type="protein sequence ID" value="CDP13205"/>
        <property type="gene ID" value="GSCOC_T00038072001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXI0"/>
    <dbReference type="OMA" id="NFQSNFA"/>
    <dbReference type="OrthoDB" id="1864854at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXI0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057619">
        <property type="entry name" value="PH_PHS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25349">
        <property type="entry name" value="PH_PHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poor homologous synapsis 1 PH" evidence="1">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="306" mass="33542" checksum="F3C9569A598E66B8" modified="2014-10-01" version="1">MAGSPVPIDSSSNDKAMAMNPILEQWQVQYARFVHFPPISSVSSAAAHHQHLLVPRSNTSRKIRKGGVWFSTSSSSSAATAVGTACLKLIGSSDDAILNLSVHGKVLVSCVSGFPARGSRAIFVSYKDFTSFFFLVLQVQKFTLRFLTIYEAEAFIDALKETLYNAPDKLQGLKYNSELSSQSEFVPPIGLPYRTEEDTCNITTAEAMNHQGLASLNCIVDKHSNDQEAIHNPEVEDFPVDFPPSFTSFLRNCCPAAEKNAVLATLPEENDLKAQIARYLEDSSFQADILVKVEKVINEIGDGVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXS3</accession>
    <name>A0A068UXS3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 45A-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00037894001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXS3"/>
    <dbReference type="FunCoup" id="A0A068UXS3">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13102">
        <property type="protein sequence ID" value="CDP13102"/>
        <property type="gene ID" value="GSCOC_T00037894001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXS3"/>
    <dbReference type="OMA" id="HWEDLMN"/>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXS3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46285:SF3">
        <property type="entry name" value="PROTEINASE INHIBITOR I4, SERPIN (DUF716)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46285">
        <property type="entry name" value="PROTEINASE INHIBITOR I4, SERPIN (DUF716)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35785" checksum="88B83FBEB88BDA1C" modified="2014-10-01" version="1">MGTMVGHVAPGFGFFLIGLWHLINHVRLHSLHPKSYTSLPWFPTSKIRYLEHFLIMGGCLASISMELFIGPHRHQPLDTDGTIPSYHLHNFEHSNISLTFFVYSLFSIILDKIQPPAHYSLTLMLGAIAFGQQFLLFHLHSADHMGVEGQYHWLLQIVIFVSLLTTLLGIGYPKSFLNSFIRSLSILFQGIWLMVMGIMLWTPEYIPKGCFINEEGHKVVRCQNHEALERAKSLVNIEFSWYLVGVTIFGMCVYLALYRMFPEKVEYQSLTKFEDQELEDDDLEAQKRNKVGGTKASFLPLGKSLELTDMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXW0</accession>
    <name>A0A068UXW0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037960001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXW0"/>
    <dbReference type="Gramene" id="CDP13132">
        <property type="protein sequence ID" value="CDP13132"/>
        <property type="gene ID" value="GSCOC_T00037960001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXW0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="62" mass="7705" checksum="D30F7BADAC3D450D" modified="2014-10-01" version="1">MNCQFYSFKYLLQFLFCNFHSGFQNFQMVFWRVFLGFGELWVQLYKMVVIYYICGTAKRWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ55</accession>
    <name>A0A068UZ55_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038877001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739161">
        <property type="protein sequence ID" value="CDP13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ55"/>
    <dbReference type="Gramene" id="CDP13815">
        <property type="protein sequence ID" value="CDP13815"/>
        <property type="gene ID" value="GSCOC_T00038877001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ55"/>
    <dbReference type="OMA" id="HISWCES"/>
    <dbReference type="PhylomeDB" id="A0A068UZ55"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF18">
        <property type="entry name" value="RX N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="2">
        <location>
            <begin position="58"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="488" mass="55654" checksum="6EC3B725FF6BE90F" modified="2014-10-01" version="1">MHDLVNDLARFVFGKLCVILFINLISRRSKDIRTFLPLRMDQDLDRTCFLSNKFLEDTLPQFMALRVLSLSYYENIVKLPNSCSGLKQLRFLDLSSTKIKELLKWICSFYNLQTLLLSKCKELEELQANLGKLINLCCLDISETPLKKMLPQMGILINLRVLTAFVISKDNGLTIKELGKLPMLRGKLFLSGLENISSGMDASLANMEGKKNLEKLTLKWHIPEGEVFNRLEEFNIIDYPKLIGKLPQQLSLLQSFEISNCSNLVTLPLRLNQFSRLEKLTIDDCESLLPLHVSRLPASLKSLECYNYNLELESESSEEDGTLDYLRLENCDSLKVERLASFPKLKGLSIIDCKSIEVLSIPAASGIVRGLPSSLQSLKILRCKKLTSRWKEWGLEKLPYLTDLWISLQNLKVLNYSGLRHLTSIQHLVIGFCHRLQYLPEKGLPASLTTLDISDCPMLKPRLEWDKGQDWPKIAPIPCLVIDDELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1E8</accession>
    <name>A0A068V1E8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00040656001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1E8"/>
    <dbReference type="FunCoup" id="A0A068V1E8">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1E8"/>
    <dbReference type="Gramene" id="CDP14329">
        <property type="protein sequence ID" value="CDP14329"/>
        <property type="gene ID" value="GSCOC_T00040656001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1E8"/>
    <dbReference type="OMA" id="STHECYS"/>
    <dbReference type="OrthoDB" id="782148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF15">
        <property type="entry name" value="PROTEIN NDH-DEPENDENT CYCLIC ELECTRON FLOW 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="301" mass="33224" checksum="E324FFFEBC329F99" modified="2014-10-01" version="1">MTMENGSVAKLMLPSGLITSYKPLMWHGATMELLHTSVSEGENGEALIHGGVSLDLKFDLNGILWSPKTWTLRGVQGSSLEFIRVELISQNVESNIEVKQIITLGEDALSSEILVCNSSDSSVHFTGAVISHLTASTPEATYAIGLEGSDFFSKTPLLTDFSLIHPSFGKIGSRKARGLMDFTGFFSGWGVDQDSERTRKETEEGLEGEEEDGYKNLAEEMSRIYTSAPRDFTVLDRGRRNSVLVGRNGFNELYMFSPGSSHEWYGKYSYICVGQAALLQPITLSSQSEWRGKQRLCNPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1H7</accession>
    <name>A0A068V1H7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00040848001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="18"/>
    <dbReference type="EMBL" id="HG739169">
        <property type="protein sequence ID" value="CDP14422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1H7"/>
    <dbReference type="FunCoup" id="A0A068V1H7">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1H7"/>
    <dbReference type="Gramene" id="CDP14422">
        <property type="protein sequence ID" value="CDP14422"/>
        <property type="gene ID" value="GSCOC_T00040848001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1H7"/>
    <dbReference type="OMA" id="YYESRTE"/>
    <dbReference type="OrthoDB" id="1930390at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1H7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000237">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000013">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase LECRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF119">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655325" description="Receptor-like serine/threonine-protein kinase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="508"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP14422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="797" mass="89075" checksum="17FF289B0E7CAAE7" modified="2014-10-01" version="1">MAYTFFHLIFFILLIPLCSLAQNNGIVPIGSILTANEASNTWLSPSGDFAFGFQQPDDKDLFLLSIWYHNIPQKTVVWYVNSSDSIPRGSTVKLDAQIGLVLRDPQGVQLWSTNAISDQLDHGFMNDTGNFVLKGRDNSSLWESFSFPADTILPLQELETGSVLNSRQSETNFSQGRFSLQFLDNGDLVLTARSLPNTTYDDVVYYNSQTSKPTNTSNSGYRLVFGSRGIISIVNSNNQTEQIGSPTLFPPVAEDYFRATLDSDGILASYYHPRNFTGNQNWTVLWSEPDDICSAAAAETGSGACGYNSICNLVNGRPACECPDGYTLLDPNDKSGSCMPNSTPSCDEVEQGTAGELYDFVVINGTDWPKSDYQIMRPSTEIGCREACLHDCFCAAAIFRNNTCYKKKLPLSNGWTRGILNTVAFLKYRKSDAPPGMEGPSSRPKDRETLIVVESVLLGSSFFLNILLIVAACSGFYLIYKKNMVKSRPNGATNLRYFTYKELVEATNGFKEELGRGSFGIVYKGELQISSKSSGIAVKKLDRVAQDTEKEFRAEVNTIGQTNHKNLVRLLGFCDEGQNRLLVYEYMRNGTLSSFLFTTPKPSWKLRTQIAMGIARGLTYLHEECSTQIIHCDIKPQNILLDDYYNARISDFGMAKLLAMNQSRTLTNIRGTKGYVAPEWFRNTQVTAKVDVYSFGVLLLEIICCRRSVENIESVEEGYAILTDWVWDCFQERRLDTLVENDSEALNDKMMLERFVKVGIWCVQEDSSIRPTMRKVSQMLEGIVEVMVPPCPSPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1S3</accession>
    <name>A0A068V1S3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00038950001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="HG739161">
        <property type="protein sequence ID" value="CDP13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1S3"/>
    <dbReference type="FunCoup" id="A0A068V1S3">
        <property type="interactions" value="2321"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1S3"/>
    <dbReference type="Gramene" id="CDP13843">
        <property type="protein sequence ID" value="CDP13843"/>
        <property type="gene ID" value="GSCOC_T00038950001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1S3"/>
    <dbReference type="OMA" id="YIVRSHN"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1S3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000036">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000026">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF448">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="985"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114202" checksum="51E325F6A5E6C1D5" modified="2014-10-01" version="1">MEKYLRKNFDVEPKRPSEEALRRWRSAVWLVKNPRRRFRMVADLAKRAEDARKLENFQEKIRVALYVQKAAFHFIRVSRGEQYRISEEIKQAGYGIDPDELATIMRNHDFKRLEQHGGVEGCAKKLSVSIQNGVSSNEIHRRQKIFGVNQFVEKPARPFWMFVWDALQDMTLIILMVCAVISVGVGIATEGWPGGMYDGLGIILCIFLVVLVTAVSDYKQSLQFKDLDREKKNVIVQVTRNGSRQKVSIHDLVVGDIVHLSIGDLVPADGMFLSGYSLSVDESSLSGESEPVDIGKENPFLLSGTKVQDGSGKMLVTSVGMMTEWGRLMDTLNEGGEDETPLQVKLNGVATIIGKIGLTFAILTFLVLTFRLIATKAIHGQIRKWSTNDALDLLNFFAIAVTILVVAVPEGLPLAVTLSLAFAMKKLMNDRALVRHLSACETMGSANCICTDKTGTLTTNHMIVTRLWICGECKIIGSNSSQNALMSTASEEVLHTLLQSIFQNSSGEVVKGKDGKPSVLGSPTETALLEFGMLFYGNSAPIFRESKILKVEPFNSNKKKMSVTVSLPGGGVRAFCKGASEIVLGMCDKLIDKDGRSVLLTVDQRKSLTDVINGFACEALRTLCFAFKDIEGNSSTDDIPESSYTLIAIVGIKDPVRPGVREAVQTCLDAGIIVRMVTGDNIHTAKAIARECGILTDDGTAIEGPEFREKNLQEMKEIVPKLQVMARSLPLDKHKLVTFLRKELREVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKENADVVIMDDNFATIVNVAKWGRSVYFNIQKFVQFQLTVNVVALITNFVSACITGSAPLTAVQLLWVNMIMDTLGALALATEPPHDGLMRKPPIGRDVNFITKIMWRNIIGQSVYQLAVLGVLQFQGKKLFNLSGPDSTSTLNTLIFNTFVFCQIFNEINSRDMEKINVLRGIFGSWIFMWIIVSTVAFQVVIVEFLGTFADTVPLSWNLWLASIFFGAAGLLVGVVLKCIPVSLERKTTATASSHHDGYEALPTGPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3G7</accession>
    <name>A0A068V3G7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">X8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00042680001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739179">
        <property type="protein sequence ID" value="CDP15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3G7"/>
    <dbReference type="STRING" id="49390.A0A068V3G7"/>
    <dbReference type="Gramene" id="CDP15107">
        <property type="protein sequence ID" value="CDP15107"/>
        <property type="gene ID" value="GSCOC_T00042680001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3G7"/>
    <dbReference type="OMA" id="HRYMQKK"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3G7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="X8" evidence="7">
        <location>
            <begin position="240"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="330" mass="36540" checksum="D7781ABBAE4BE9E3" modified="2014-10-01" version="1">MRRILDSVRSHNIHNIKVGTPLAMDILESTFPPSSGKFRSDIPHDQVIIPLLQFLNQTKSYFFLNVFPYFTWSANPTNVSLDLALFRGDKNSSYRDPESGLIYTNLLDQMLDSVLFASKKLGLDHVALAISETGWPHAGDIDQPGANRYNAATYNRNLVRRMSAEPPIGTPARPSVFIPTFIYALFDEDQIPGRGTARHFGILQANSWPVYDLDLTGKLGEGDYPPLPLPSNNEPFKGNLWCVVASEANIMELVPQLESVCSLGNGICDALSPGNDCYEPVTIRAHASYAFSSYWVKFRSRGAACHFNGLAVLSTTDPSHGSCKFPSVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V444</accession>
    <name>A0A068V444_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00042922001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739181">
        <property type="protein sequence ID" value="CDP15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V444"/>
    <dbReference type="Gramene" id="CDP15264">
        <property type="protein sequence ID" value="CDP15264"/>
        <property type="gene ID" value="GSCOC_T00042922001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V444"/>
    <dbReference type="PhylomeDB" id="A0A068V444"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="55" mass="6279" checksum="118FC4857BC540FF" modified="2014-10-01" version="1">MGTLSTSPLLPKDLRPSSLYREHRSSVFVYTTRRRKSKKSQSLNPVARLFGPAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5I4</accession>
    <name>A0A068V5I4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017041001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739199">
        <property type="protein sequence ID" value="CDP16040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5I4"/>
    <dbReference type="STRING" id="49390.A0A068V5I4"/>
    <dbReference type="Gramene" id="CDP16040">
        <property type="protein sequence ID" value="CDP16040"/>
        <property type="gene ID" value="GSCOC_T00017041001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5I4"/>
    <dbReference type="PhylomeDB" id="A0A068V5I4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF467">
        <property type="entry name" value="CARBOXYLESTERASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="117" mass="13000" checksum="075E287F7DE2C468" modified="2014-10-01" version="1">MLLCYYNLKNFKPLVSTSILQISATSHSSVIFLSSSGKYLFVLSWYSGFQYGSLVKLFLVVQLEVRFGDTKLPLFVYLHGGGFLIKSAFSPTYHAHLNVVVAEAGVITVSINYRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V626</accession>
    <name>A0A068V626_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00016920001</name>
    </gene>
    <organism evidence="14 15">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">cv. DH200-94</strain>
        </source>
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            <name>heme</name>
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        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00016920001"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
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        <location>
            <position position="397"/>
        </location>
        <ligand>
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        </ligand>
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        </ligandPart>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="449" mass="51566" checksum="44BA38DC971BDC4A" modified="2014-10-01" version="1">MIEEAYSQPINLSDDLVPRVIPMVTKTIKKYGGNSFIWLGPYPAVIILDSESIREIMVKYNLFQKPYFHPLGKYLIQGLVASEGKKWAKHRKIINPAFHLEKLKLMLPAFHLCATEMLSKWEESVSSEGTCELDVWPHRQTLTSDAISRTAFVVIMRKEERSLSFKKNRQSRLKILTFLISKLIQSVSLLVYWFLPTKRNRRIKELHKKVGAAVREVIDERLEAMKAGESSDNDLLSILLDFGLSINDVIEECKQFYFAGQETTSSLLVWTSVLLSRHQKWQSQAREEVLQVFGRDESNFNGLNLLKVVTMILNEVLRLYTPLPVIDRTVQEETKVGKYTFPSGVRLMLPVLLLHYDVEIWGDDSEKFNPDRFHEGVSNATKGQASFFPFGWGPRICIGQTFAMIEAKLAMAMILQRFSFELSPSYTHAPYTIVTIQPQHGAHLILRKL</sequence>
</entry>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
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                <person name="Perrotta G."/>
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                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
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                <person name="Henry R.J."/>
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                <person name="Rounsley S."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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            <end position="165"/>
        </location>
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    </evidence>
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        <lineage>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
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                <person name="Garsmeur O."/>
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                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739207">
        <property type="protein sequence ID" value="CDP16372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V742"/>
    <dbReference type="FunCoup" id="A0A068V742">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V742"/>
    <dbReference type="Gramene" id="CDP16372">
        <property type="protein sequence ID" value="CDP16372"/>
        <property type="gene ID" value="GSCOC_T00018209001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V742"/>
    <dbReference type="OMA" id="HGMNDES"/>
    <dbReference type="OrthoDB" id="1883668at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V742"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009718">
        <property type="term" value="P:anthocyanin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010120">
        <property type="term" value="P:camalexin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042538">
        <property type="term" value="P:hyperosmotic salinity response"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900056">
        <property type="term" value="P:negative regulation of leaf senescence"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000007">
        <property type="entry name" value="NAC domain-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF65">
        <property type="entry name" value="TRANSCRIPTION FACTOR JUNGBRUNNEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="303" mass="34266" checksum="27157A8DDC0EF02D" modified="2014-10-01" version="1">MEEFKSSNKNHKDDDGVVLPGFRFHPTDEELVGFYLRRKVERKPLRIELITQVDIYKCDPWDLPLPKVGVVGDKEFYFFCMRGRKYRNSVRPNRVTGSGFWKATGIDKPIYSSGETTQCIGLKKSLVYYRGSAGKGTKTDWMMHEFRLPPGWTHSTSTQPNPRNNIAQETDDWTLCRIFKRNASSKRYKPDLKHACTKGGSGAASSKPCSLQSQNSCHPYTTLEDVGFQQRTNAAAGIDVNHSSQFLAAQEQILLVAQTSYSSSSSNFWNLNGDEFFRDGRWDELSSVVDSAADMSNPFARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7D3</accession>
    <name>A0A068V7D3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016626001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739194">
        <property type="protein sequence ID" value="CDP15793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7D3"/>
    <dbReference type="STRING" id="49390.A0A068V7D3"/>
    <dbReference type="Gramene" id="CDP15793">
        <property type="protein sequence ID" value="CDP15793"/>
        <property type="gene ID" value="GSCOC_T00016626001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7D3"/>
    <dbReference type="OMA" id="EVEICVM"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7D3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04051">
        <property type="entry name" value="C2_SRC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044750">
        <property type="entry name" value="C2_SRC2/BAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246:SF22">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246">
        <property type="entry name" value="INGRESSION PROTEIN FIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="21063" checksum="E06DB5D182BE06D3" modified="2014-10-01" version="1">MECRQFEVTLISAVNLPNVRELGQMKVYAKVLIKGYSNSEWITSVDRERETNPYWNCRIKYTLPEKAVEKDGVLLVIKLYCERSLLPDKYVGEVNLSLKKLFDYGFPQEKLEYYVNRNDVDGKFGKLKLSYDFGKTTVTISEKEPSFGEAVVEGAMNGVLHAAIHEVLSEILFFEVEICVMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V810</accession>
    <name>A0A068V810_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Morc S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00005278001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MORC ATPase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739224">
        <property type="protein sequence ID" value="CDP16925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V810"/>
    <dbReference type="FunCoup" id="A0A068V810">
        <property type="interactions" value="2098"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V810"/>
    <dbReference type="Gramene" id="CDP16925">
        <property type="protein sequence ID" value="CDP16925"/>
        <property type="gene ID" value="GSCOC_T00005278001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V810"/>
    <dbReference type="OMA" id="HKVRSQN"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V810"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:gene silencing by siRNA-directed DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060966">
        <property type="term" value="P:regulation of gene silencing by regulatory ncRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000075">
        <property type="entry name" value="MORC family CW-type zinc finger protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045261">
        <property type="entry name" value="MORC_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336:SF44">
        <property type="entry name" value="PROTEIN MICRORCHIDIA 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Morc S5" evidence="15">
        <location>
            <begin position="336"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="574"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP16925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="637" mass="71631" checksum="0692CFB2F395DAB8" modified="2014-10-01" version="1">MREECVDLVPQTFRLHCVGKESEENKNSSALSAGNSGTSAVDEEQSLVDDSSLCSTSPIGSAPLCRQFWKAGSYDDTLSTKPSLQKGANYLHIHPKFLHSNATSHKWAFGAIAELLDNAIDEIQNGATVVIVDKILNPRDGSSALCIQDDGGGMDPEAMRRCLSFGFSDKKSNSAIGQYGNGFKTSSMRLGADVIVFSRCKKNRKLTQSVGLLSYTFLTQTGHDRIVVPMLDYEFNTQSNMWDKLSNTQCINNLPLLLRWSPYSTEAELLKQFDDVGQHGTKVIIFSLWYTDDGQMELDFESDPEDIRISEVANTNKKSARMMVASEQHLANRLRFSLRAYLSILYLRVPENFCMMLRGKCVQYHSIANDLKFPEFILYKPQSGGCKEGTVVTAIGFLKEAPLVNIHGFNVYHKNRLILPFWHVVSYSDSRGRGVVGVLEANFIQPTHNKQDFEKTPVFQKLESRLKEMTREYWDYHCQLIGYQPRKARAMTFQASSDSGKNDGIYQPVQLTRDDLASDCNLQKGAPSKRKESNHLVEPDRVRRKVGIGANATVCNQENLRAGVATDELKSGEAANLIQENRKLQAQCLEFEKTVEELNLKAARLRVELGEARREHSRLLAEFKLVEKVKEEKSNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V862</accession>
    <name>A0A068V862_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00019365001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739221">
        <property type="protein sequence ID" value="CDP16831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V862"/>
    <dbReference type="STRING" id="49390.A0A068V862"/>
    <dbReference type="Gramene" id="CDP16831">
        <property type="protein sequence ID" value="CDP16831"/>
        <property type="gene ID" value="GSCOC_T00019365001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V862"/>
    <dbReference type="OMA" id="HCANANS"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V862"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="115" mass="13604" checksum="A7D7E150481DB4B8" modified="2014-10-01" version="1">MRRMRVLRRLLRKYRESKKIDRHMYHDMYMKVKGNVFKNKRVLMESIHKSKAEKAREKTLSDQFEAKRAKNKASRERKIARREECLAQGPGERPVQPAVLAPPAQTAQVSKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8H9</accession>
    <name>A0A068V8H9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017297001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8H9"/>
    <dbReference type="STRING" id="49390.A0A068V8H9"/>
    <dbReference type="Gramene" id="CDP16198">
        <property type="protein sequence ID" value="CDP16198"/>
        <property type="gene ID" value="GSCOC_T00017297001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8H9"/>
    <dbReference type="OMA" id="CSPIHEG"/>
    <dbReference type="OrthoDB" id="1621957at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8H9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31549:SF167">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31549">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF247)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="525" mass="60114" checksum="D611833B7B91703F" modified="2014-10-01" version="1">MEHSYSSGTVPLSSSARDWVDRVSNIFRREFAIDIDHLPPVSVFEVPKILKLQKPEAYTPHLIAMGPYHHLHPELYHMERHKLAAIKEISTPDQLSNFQHVVINRLKEMDPSIRACYNKFMDYDQDTLAWIVAIDGCFFLHILHSYLVQDENTDRRLLDNTIVTRDIVMLENQIPFVLLKKIRKSLQVSPNSNGQEEGDDIELILMLFQLCEAQSPVKFSSDKTNQDRYRRPLHLLDMMYHLIVNVPAIPTYTEFRNSLTSSSSSSSTDGENPGVFRNNNLEAILELVETFGNKRTQDLLRPVKLVSSIPWSTISGLFRKGNVGTKEQNSEDDEIEIPSVSHLWRYAKVQCKPFIGSIKEIKFVEEEAALYLPVMNLNASSEVIMRNLVAYEAAMSKPTLEFARYVNLMNGIIDTAEDVKLLKQNGVIKGGLTDDEIADQFNGMKRCYAGSDHKSNIEVAVEKVNKFYGKKLLVRTVRRLNRSLFASWKHLALVSTVVLLVVLSLQTFCEFYQCSKIWNFHQEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9L0</accession>
    <name>A0A068V9L0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00019092001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9L0"/>
    <dbReference type="STRING" id="49390.A0A068V9L0"/>
    <dbReference type="Gramene" id="CDP16638">
        <property type="protein sequence ID" value="CDP16638"/>
        <property type="gene ID" value="GSCOC_T00019092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9L0"/>
    <dbReference type="OMA" id="WADPTAN"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9L0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="3 13" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11 13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5 13" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP16638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="18569" checksum="759A3D924C1B1CDE" modified="2014-10-01" version="1">MLEALGCITLEVLEKYLKVDFKEPVWFKAGAQIFSEGGLDYLGNPNLVHAQSILAVLGFQVVLMGLVEGYRINGLEGVEEGNDLYGGQYFDPLGLADDPVTFAELKVKEIKNGRLAMFSMFGFFVQAIVTGKGPLENLLDHLDNPVANNAWSMPPSLSPDRKVFLLCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA73</accession>
    <name>A0A068VA73_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00001841001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739247">
        <property type="protein sequence ID" value="CDP17477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA73"/>
    <dbReference type="Gramene" id="CDP17477">
        <property type="protein sequence ID" value="CDP17477"/>
        <property type="gene ID" value="GSCOC_T00001841001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA73"/>
    <dbReference type="OMA" id="DLNCKME"/>
    <dbReference type="OrthoDB" id="1926275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA73"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF187">
        <property type="entry name" value="AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="101"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="831" mass="94946" checksum="9562C370B405CE0C" modified="2014-10-01" version="1">MSGKKKRKSEVDNWLKDVKKLSPEIDALETRGSSWRLPLKEDPVGKLQLQVKELIQQSHHFNGLVLDAYDNIGEPCLPTKLFGEKFKQNLERTWPCLVIDDISSIGIYGMGGVGKTTLAQHIKYYLSKNTNYQVLWVTVSQEFSINSLQDKIANVLGFHLSNKDEEQVRADILRGAFRKMKRLIVLILDDVWQEFCLDKVGIPLDARSCRLILTTRSLEVCNRMRCQRKFDLKTLDTNEAWDLFKYKLGSETLLHGDVEDITKSVVKRCAGLPLGIITVAGSMQGVGDISEWRNALEQLKACSVGHDEIERDVFPILEWSFNRLNECLKHCFLYCSLYPEDSEIERKELIELFIRAELMPKRKSRSEEFDQGHTILNKLIKVCLLEETTDFSGNDYVKMHDLVRDMALRITSGNSKKKMSTDVPWFLVKRIEEGNSRVTLEQKEWTEDLHVASLYGGDELKVPLAWSPNCPKLSILLLDFPWIERIPDSFFMHMSGLKVLHLSNSELIGKLPNCVSDMVSLTALVLTGCQGLDSLPPLGKLKQLRELDLSWTDIQDLPQGLESLINLEWLNLNACSSLIQKIIPKETFTQFHHLQLLISGLDGIEFLLQFFFAPTPCDQLEVSSFSPLQNLQALKLNNLPNLVGLFYWEIEAYFLPLGIFSSLTKLWISYCHNMKQLFTMQLLQNLKNLEDLEIRNCEGLKEIAADNNGVGKGGKEGIQLTSSEATTTIILPKLKRLHLTWLPQLKNICTAAMICNSITEIEMFGCPKVKRLPLFLLTINGLPFVPSTLHKIRGDKEWWESLEWENPSAKNALDPFFTTTDRRQDVMTMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD94</accession>
    <name>A0A068VD94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00005576001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739372">
        <property type="protein sequence ID" value="CDP18800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD94"/>
    <dbReference type="STRING" id="49390.A0A068VD94"/>
    <dbReference type="Gramene" id="CDP18800">
        <property type="protein sequence ID" value="CDP18800"/>
        <property type="gene ID" value="GSCOC_T00005576001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD94"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="204" mass="23583" checksum="89E03B754778326C" modified="2014-10-01" version="1">MDHSCTYYTLILSLSLSISFMDHNSTAFCLSFPYICRYTYIRNYSQLDMITGIVIRSHSSHYSLMLPFFIYPNSTLFNPRSPPNNAKKIKPQLHPSSLPSLLQYVSKILLKTLNRVILLVLKRTTVSLSLSLYLRTRDSEMFLQFYINENGDKVYTTKKESPVGAITLSAHPARFSPDDKYSRQRVLLKKRFGLLPTQKPPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE61</accession>
    <name>A0A068VE61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00007307001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739434">
        <property type="protein sequence ID" value="CDP19110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE61"/>
    <dbReference type="STRING" id="49390.A0A068VE61"/>
    <dbReference type="Gramene" id="CDP19110">
        <property type="protein sequence ID" value="CDP19110"/>
        <property type="gene ID" value="GSCOC_T00007307001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE61"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VE61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12765" checksum="E62C0C5D2221D66C" modified="2014-10-01" version="1">MSTILMLSVYYFQQQTYIFMAIFSSSTETIDGGNSTLSPPRDGVLRVNVRFPTRVFNSLSPEVKDLLRRMLSKGVIRRFTAEQVLTHPWMTGEGGDEIRPVAIEEARPVAIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEA9</accession>
    <name>A0A068VEA9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00008639001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739282">
        <property type="protein sequence ID" value="CDP18033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEA9"/>
    <dbReference type="FunCoup" id="A0A068VEA9">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEA9"/>
    <dbReference type="Gramene" id="CDP18033">
        <property type="protein sequence ID" value="CDP18033"/>
        <property type="gene ID" value="GSCOC_T00008639001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEA9"/>
    <dbReference type="OMA" id="HEVCFDD"/>
    <dbReference type="OrthoDB" id="1918611at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEA9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022203">
        <property type="entry name" value="DUF3727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36061">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36061:SF3">
        <property type="entry name" value="OS04G0692200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12527">
        <property type="entry name" value="DUF3727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22519" checksum="D7DBF9DCA380A0A5" modified="2014-10-01" version="1">MDEQGRVVLASNKRIATIVDCTNNFPLECVIRRIFRNAQGDECMLLCPVDTPVQILKSTNVEGWSAVSDEEVEAILPTAAYALAKIHMHLVYSGFCYTARGGFCYTEDDIFEFRTDDGQDVDGLPTEGIEITCFHLDGSHYMIYTPSDPLLFVAVKDANGILQIAEDELLEDPATISAIDEETEFNALVEEETALIESLLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEM1</accession>
    <name>A0A068VEM1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00005527001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739414">
        <property type="protein sequence ID" value="CDP19019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEM1"/>
    <dbReference type="Gramene" id="CDP19019">
        <property type="protein sequence ID" value="CDP19019"/>
        <property type="gene ID" value="GSCOC_T00005527001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEM1"/>
    <dbReference type="OMA" id="HEKFENI"/>
    <dbReference type="PhylomeDB" id="A0A068VEM1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF45">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="166"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="415"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="11">
        <location>
            <begin position="501"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP19019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="859" mass="98246" checksum="27E58232CABB92AE" modified="2014-10-01" version="1">MAELFVPKIIDELGDVVVKQLGEKINLVMGVEKEVANIKRKLETIQNVLHDVERRRLKDKSVGKWLEELEDLTYEMDDVLDEWNIKIQKPKNEGTQQNARLQATFDIALKIKSINEKLELTLKEADQFKFISIGGIPDSQRIMTTSIIDESEVCGREFDKDALLDQVLSKSSSQGRKGVQVISVVGAGGSGKTTLAQLLFNNDKVKVHFELRNWICVSDPFDQKRIAKAILENAGKSSQESELDPLIQRIKETFSGKRFLLVLDDVWTEDDSKWKPFQYSLKDGAPGCVILVTTRSHRVATAVGSTATHDLGMISDSDCWLIMQRLAFANKSGDLCKKVESIGQKIAEKCKGLPLAAKTMGSLLRFKDTVQQWQNVLDSEIWQLKEAAVELFPHLYLSYNELSPELKRCFSYCAVFPKDHVIYVEEELIGMWIAQGYVLPRRRGERLELVGREYFNNLAMRSFFQELEKVGDEYKQCKMHDIVHDFAQFLTKNEFVDFGRLRSFLTFPEIGRVVVPQNLFSRLKCVRTLTLSRRGLAEIPAEIGRLIHLRHLGLSNNNFVALPEAICDLYYLETLDISCCRMLSCLPERIEGLVHLRHLHNYVALELRQIPQGLRKLTSLCSLTWFVARVNSDDLAILKDLNRLEILYIKIEGEVDFGSAKLGKKINMREMRLIFSDGTHFIETPSYIESMEPPPKLERLVLYGYPGAQLPSWLMTKSHANNLTRLFIDSPGNISSLLALWKLSSLEELLLSGAEKLECLGKEFLGVTKALHENTEVVAFPNLRKLHFNYLPNWTNWEDLSEDDEELEVLPHRILGRISSLKTLDIRNCFKLSDHYSNKTGDDWIKISHIPRVHISDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEW3</accession>
    <name>A0A068VEW3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00004564001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739540">
        <property type="protein sequence ID" value="CDP19370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEW3"/>
    <dbReference type="STRING" id="49390.A0A068VEW3"/>
    <dbReference type="Gramene" id="CDP19370">
        <property type="protein sequence ID" value="CDP19370"/>
        <property type="gene ID" value="GSCOC_T00004564001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEW3"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEW3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP19370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="67" mass="7716" checksum="619A205622786F8C" modified="2014-10-01" version="1">MVSLKLQKRLAASAPKCGRGKVWLDPNEVNEISMADFHQNTRKLVKDGFIIRKPTKIHSRSRAPWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF63</accession>
    <name>A0A068VF63_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00010986001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739310">
        <property type="protein sequence ID" value="CDP18338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF63"/>
    <dbReference type="STRING" id="49390.A0A068VF63"/>
    <dbReference type="MEROPS" id="I03.030"/>
    <dbReference type="Gramene" id="CDP18338">
        <property type="protein sequence ID" value="CDP18338"/>
        <property type="gene ID" value="GSCOC_T00010986001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF63"/>
    <dbReference type="OMA" id="GNGWPFY"/>
    <dbReference type="OrthoDB" id="1872570at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011065">
        <property type="entry name" value="Kunitz_inhibitor_STI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002160">
        <property type="entry name" value="Prot_inh_Kunz-lg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107:SF5">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00197">
        <property type="entry name" value="Kunitz_legume"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00291">
        <property type="entry name" value="KUNITZINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00452">
        <property type="entry name" value="STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50386">
        <property type="entry name" value="STI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00283">
        <property type="entry name" value="SOYBEAN_KUNITZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658569" evidence="2">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="215" mass="23675" checksum="96DFE6E53A489A90" modified="2014-10-01" version="1">MKKLLLFLSFLLFNSFLSFAAEEPNPVLDINGEEIRPGVEYHIVSAIFGGGGGGVTYGKGPGNQICPLAVVQALSDLNRGHPVSFTPVNPEEGVVRVSTDLNIKFSPFINFCRGSNVWKVHFNEALEQHFVLTDGVEGNSGCETEANWFKIEGNYPFYKLVFCPAVCDSSSEAICKDVGIYYDDDGTRRLALSDRPFVVFFSKKNEDILKSVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFT5</accession>
    <name>A0A068VFT5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00005782001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739587">
        <property type="protein sequence ID" value="CDP19457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFT5"/>
    <dbReference type="FunCoup" id="A0A068VFT5">
        <property type="interactions" value="2518"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VFT5"/>
    <dbReference type="Gramene" id="CDP19457">
        <property type="protein sequence ID" value="CDP19457"/>
        <property type="gene ID" value="GSCOC_T00005782001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFT5"/>
    <dbReference type="OMA" id="DTNNYLH"/>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFT5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="249" mass="27230" checksum="C08CF1F095B0BA49" modified="2014-10-01" version="1">MTVAAGIGYALLALGPSLSLFVAAISQKPFLILTVLSSTLLWLMSLIVLAGVWRAFLPFKTTPSSSAWLPYSILILSSVVFQEGLRVLFWRIYKKLEDILDAFADRVSKPRLFLTDKMQIALAGGMGHGVAHAVFFCLSLLTPAFGPATFYVEKCSQMPFFLVSSMIALAFVTIHTFSMVIAFNGYAEGNRVDQLIVPVVHLVAGMLTLVNLSSGGCIIGIPLLYCMALFTLLHCGKMVWKRLADSQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG42</accession>
    <name>A0A068VG42_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00006975001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
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        <property type="protein sequence ID" value="CDP19572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068VG42"/>
    <dbReference type="Gramene" id="CDP19572">
        <property type="protein sequence ID" value="CDP19572"/>
        <property type="gene ID" value="GSCOC_T00006975001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG42"/>
    <dbReference type="OMA" id="WVKGFED"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VG42"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000028">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057732">
        <property type="entry name" value="SH3-A_UBE2O"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057734">
        <property type="entry name" value="UBE2O-like_SH3-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF21">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23048">
        <property type="entry name" value="SH3-A_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23044">
        <property type="entry name" value="SH3-C_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="889"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="716"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1138" mass="125984" checksum="2A284C7C4D245439" modified="2014-10-01" version="1">MDTGPGQHNVASKDVVPVTTANNDADLKEDDSPVNGLYYNQNVIPANKPGDILKNLQNVSYVYRQDVVRSSINSKLGIVTEVAGDSDSDGSLTDDDDDDDDDEVDDDDGDDDDAEVDNSQKVNQTKDSDSQKNHNLPADQVRVLWIDESETTESINNVKVVDRGFLHGDYVAAASDPTGQVGVVVDVDISVDLLTHDGSIIENISARDLKRVRDFTIGDYVVLGPWLGRIDDVLDNVTVLFDDGSVCKVMKADPLRLKPVGKNILEDGHFPYYPGQRVKANSSSVFKNSRWISGLWKANRLEGTVTKVTVGSVFIYWIASAGYGPDSSTTPAEEQSPKNLKLLSCFSHANWQLGDWCLLPSPVLLSSIPLDKGLSKLELCDSVKEESESAQTGAECSEVVTSEESNGNSELIVLDAEVSLEANNGKAEAKAPAESSSCSSSLSISKESVHESWPLHRKKIRKVIVRRDKKARKKEDNFERALLIVNTRTSVDVAWQDGTIKRGINSTSLIPIESPGDHEFVAEQYIVEKAADDGYDTGETRRVGVVKSVNAKEKTAHVRWLKQVTRAEDPREFDREEVVSVYELEGHPDYDYCYGDVVVRLSPVSLPVEILSTTNSAEESELLHGTYEEEQDAEQHIGCKKVEDESTDEVCTEFSDLSWVGNITGLRNGDIEVTWADGMVSMVGPQAIYVVGRDDDESITGGSEISDDAASWETVEDDEMDTIENADEGVKNRSATDIRIDNEDGSDSSGRNGALSIPLAALGFVTRLASGIFSRGRKHTDPDSRSDDELQLRELAVKIDTDDESCSQRSNGGGSIGSLSTKVKAEEQDDKEVADLLDAAEALCNLKPEANVPTYHDDRASSFKGFDITKDPYDHYFRGTNEQNNASRKWLRKVQQDWNILQNNLPEGIFVRVYEDRMDLLRAVIVGAYGTPYQDGLFFFDFHLPLEYPDVPPSAYYHSGGWRINPNLYEEGKVCLSLLNTWTGRGNEVWDPSSSSILQVLVSLQGLVLNSKPYFNEAGYDKQIGTAEGEKNSLSYNENTFLLNCKTMMYLIRKPPKDFEELVQQHFRRRGYYILKVCDTYMKGYLIGSLTKDASISSNTHANSNSIGFKLMLAKIVPKLYISLSEIGANCQEFKHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGP3</accession>
    <name>A0A068VGP3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH200=94 genomic scaffold, scaffold_658</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00005337001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
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                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
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                <person name="De Bellis F."/>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="16862" checksum="66235B21A1D34FD1" modified="2014-10-01" version="1">MSPEYAVKGFFSVKSDVFSFGVILLEINSGKRNSAGFYQSEGALSLLGYAWRLWQERKSIDFVDKKILESCNETEVIKCINIGLLCVQDDPSERPSMSDILIMLSSETAALPNPNQPAFVVRRHTSKTPALSRKEQTNSINEITISVEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIY2</accession>
    <name>A0A068VIY2_COFCA</name>
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        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_1349</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012669001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740433">
        <property type="protein sequence ID" value="CDP20549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIY2"/>
    <dbReference type="Gramene" id="CDP20549">
        <property type="protein sequence ID" value="CDP20549"/>
        <property type="gene ID" value="GSCOC_T00012669001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIY2"/>
    <dbReference type="PhylomeDB" id="A0A068VIY2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="391" mass="43436" checksum="E9538768E4240E54" modified="2014-10-01" version="1">MASKSEGSQSSSTTPIAKRRLSFSSITTGLTSKEQKRAKVGEVGECSSRNFSACWCHDFKWKDQKVCPTVLGHEDPFSADNLLEDLDINRYGNVKKDIEYLIARRNQLISHGFAAKPLVPCKNLSTQKIPKKVDFGSDRYGSVTREIEELLAQSQLFGCLSSTNSTMSCKRLKKYLTKEDLESNPPSMPNIIDLEDDDEPPANGTVIKCEPAEEIDTSAKCLVVIDSVEEDPVNDNNFCHSRSSATKPVVQCWNLGVKKRPSEEDFQSNKYGSVTKEIEELLAQENQVFGVLGSTNSAMLRKRLGTEMYSCKEGWDLKPPSVPDIIDLESPDNGTIVESEPFEEIVREAKPLAVIDLDDEAFENDENSCPNEVADLAKTADNLLQNNVEVH</sequence>
</entry>
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    <accession>A0A068VKB8</accession>
    <name>A0A068VKB8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2851</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012933001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741935">
        <property type="protein sequence ID" value="CDP21225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKB8"/>
    <dbReference type="STRING" id="49390.A0A068VKB8"/>
    <dbReference type="Gramene" id="CDP21225">
        <property type="protein sequence ID" value="CDP21225"/>
        <property type="gene ID" value="GSCOC_T00012933001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKB8"/>
    <dbReference type="OMA" id="SIAGWSM"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKB8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04051">
        <property type="entry name" value="C2_SRC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044750">
        <property type="entry name" value="C2_SRC2/BAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246:SF22">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32246">
        <property type="entry name" value="INGRESSION PROTEIN FIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="17373" checksum="62708C79EF852DB9" modified="2014-10-01" version="1">MDCRKFEITLLSANDLEDVRKFFKMKVYLRVSIGRSSEEAERRTPADKHGEVNPAWNFTLKYTINESMVQHFNTMLVIKLYCKRKLGDRYIGEVHTSMKDLFDYAYPVGGSAVVSYPVQKGSVNSQGALRFSYRFGEKVWGKGMPRQTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKR3</accession>
    <name>A0A068VKR3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_3994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00007279001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG743078">
        <property type="protein sequence ID" value="CDP21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKR3"/>
    <dbReference type="Gramene" id="CDP21420">
        <property type="protein sequence ID" value="CDP21420"/>
        <property type="gene ID" value="GSCOC_T00007279001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKR3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="43" mass="4796" checksum="944E49E53F096F82" modified="2014-10-01" version="1">MCLQNENLYCLPKTAMLCASSVCSAFVGSVNIPHYFIGDIFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLA4</accession>
    <name>A0A068VLA4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00004884001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Tau family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="HG740304">
        <property type="protein sequence ID" value="CDP20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLA4"/>
    <dbReference type="FunCoup" id="A0A068VLA4">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLA4"/>
    <dbReference type="Gramene" id="CDP20458">
        <property type="protein sequence ID" value="CDP20458"/>
        <property type="gene ID" value="GSCOC_T00004884001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLA4"/>
    <dbReference type="OMA" id="WASTYVK"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLA4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009407">
        <property type="term" value="P:toxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase U9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF711">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="91"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="229" mass="26454" checksum="722F204B57C3ABAD" modified="2014-10-01" version="1">MGEEDTVILHGMWASTYVKRVELALKIKGIPFEYVEEDLSNKSALLLKYNPVQRKVPVLVHNGKPICESLVILEYIDETWPSHGLQLLPKDPYERARVRFWAAYIQQLLESMAKLFNPDHKEAQEKALEEMYEKQRILEEGMREFFPEESPNVHPEKLGILDIMIVSTLGAFRAQEEALGVKTLDPEKNPLLFSWVEALIQLPVVKEIIPPFEKLVSLLQFIKQNGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLP7</accession>
    <name>A0A068VLP7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_5331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00010302001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <dbReference type="EMBL" id="HG744415">
        <property type="protein sequence ID" value="CDP21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLP7"/>
    <dbReference type="STRING" id="49390.A0A068VLP7"/>
    <dbReference type="Gramene" id="CDP21626">
        <property type="protein sequence ID" value="CDP21626"/>
        <property type="gene ID" value="GSCOC_T00010302001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLP7"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLP7"/>
    <dbReference type="UniPathway" id="UPA00115"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF9">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="104" mass="11746" checksum="C53EAB8AC9952AA6" modified="2014-10-01" version="1">MACEIGNKTVLKFDTEDGVAVALARYIADLSERFIKEKGSFNVVLSGGSLIDTMRYLAQAPYKESVDWPKWSIFWLDGRVVPLDSKGSNYRLAWDGLLKYVTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VM08</accession>
    <name>A0A068VM08_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DH200=94 genomic scaffold, scaffold_1560</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00010330001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740644">
        <property type="protein sequence ID" value="CDP20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VM08"/>
    <dbReference type="STRING" id="49390.A0A068VM08"/>
    <dbReference type="Gramene" id="CDP20688">
        <property type="protein sequence ID" value="CDP20688"/>
        <property type="gene ID" value="GSCOC_T00010330001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VM08"/>
    <dbReference type="OMA" id="HGIECSK"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VM08"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000544">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF96">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658788" evidence="12">
        <location>
            <begin position="27"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="14">
        <location>
            <begin position="361"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="498" mass="53853" checksum="A7962F9AB28698CB" modified="2014-10-01" version="1">MGSFKIISIFVLVVIFFPSFHPKCGASASAEEAAALFKWKASFLNQNNSFLTSWKLQSGNAKNSSVLPCTWAGISCTDGSVNRLNLSDWSIKGKIPPEICNLRNLTHLDFGINQLSGPIPVAMGNLISLQFLYLCQNNLTGAIPKSLGNLTNLIELYLYENQLSGPIFKEVGDLKFLTDMELGENQLNGSIPISIGNLSNLKTLYLYKNQLSGSIFKEVGDLKFLTDMELGENQLNGSIPISIGNLSNLKTLYLHNNQLSGPIFKEVGDLKFLTDMELGENQLNGSIPISIGNLSNLETLYLQNNQFSGSIPPTFGNLNRLVDLKLFHNHLSGPIPSAIGNLISLQLLSLSENNLTGAIPKSLGNLTKLIELDLSDNQLNGSIPASIGNLSALKVLYLDNNQFSSSIPATFGNLNKLVNLTLYQNHLSGPIPPAIGNLISLQFLYLYQNNLTGAIPKSLGNLTKLIELDLSDNQLNGSIPASIGNLSTLEAGGSKAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN26</accession>
    <name>A0A068VN26_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00000203001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741554">
        <property type="protein sequence ID" value="CDP21088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CDP21088"/>
        <property type="gene ID" value="GSCOC_T00000203001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN26"/>
    <dbReference type="PhylomeDB" id="A0A068VN26"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chaperone DnaJ C-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="23800" checksum="7CFB18D3C402A07A" modified="2014-10-01" version="1">MLRETMGKLCSKGFDKGISHRKVPPPVWCPLRCTLDELYNGVEKTIKFPGGRMKLLPDPGVIAPNADPETLVVEIPAGAKNGLKIVYPRRVILDDRKVPRDVIVDVIEEPHAEFHRQGNDLWAIRKIPLMEYVTNEALTIETLDKRLLTVPKIEPGCVIEIPNEGMPCWHGIGETGSIFVSFEVIYPKNLSLTREEKDELKKLLAKEENNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQB9</accession>
    <name>A0A068VQB9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_7886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00007655001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG746970">
        <property type="protein sequence ID" value="CDP21928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQB9"/>
    <dbReference type="STRING" id="49390.A0A068VQB9"/>
    <dbReference type="Gramene" id="CDP21928">
        <property type="protein sequence ID" value="CDP21928"/>
        <property type="gene ID" value="GSCOC_T00007655001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQB9"/>
    <dbReference type="PhylomeDB" id="A0A068VQB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP21928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="203" mass="22456" checksum="D28BF1D7A34E21EF" modified="2014-10-01" version="1">MDLGRNGHANELLQAQAHIWNHIFNFINSMSLKCAIQLGIPDIIHKQGKPMTLDELQCSSNWQCKSPTLSLNNFFNEGMASDSRLVGSILIRDWKDVFSRLNSLVDVGGGTGTLAKEIADAFLDLHCIVPDLPHVVDGLVANNKSLAFVGGNMFVAIPPADDVIMKWILHDWYDEECVQILRKCKEAIPSNGNGGKLNFSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQX0</accession>
    <name>A0A068VQX0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_10545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00011316001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG749629">
        <property type="protein sequence ID" value="CDP22113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQX0"/>
    <dbReference type="Gramene" id="CDP22113">
        <property type="protein sequence ID" value="CDP22113"/>
        <property type="gene ID" value="GSCOC_T00011316001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQX0"/>
    <dbReference type="OMA" id="RRERFNC"/>
    <dbReference type="OrthoDB" id="646178at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQX0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1193">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPP13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="148"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="371"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="489"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP22113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="615" mass="70882" checksum="2D6C179BEE3FEEA7" modified="2014-10-01" version="1" fragment="single">MADPVISLVVERTGDLLIQKIVFLKGVRGQVERLQNDLVRMQCFLKDADQRQDEDARIRNWVSEIRAAAYDAEDIIEIFANKIESIKDKGFVTRLAYYPWRIVSLNKIGKEIESLQTRLDNIAVSREKFGIKNLGEGTRTHGEELQRLRRERFNCRAWVCVSSSYDHKKILRSIIKQLNPKDTKDDKLSRMLEKMEEEELEERLYQDLQDKCYLVVLDDVWKEAAWDCLVRNAFPDSSTSSKVLLTSRKRDVAVHADALSIPHELKTLGKEDSWQLFLRKALGHGDNAGCPPDLEEVGREIVRRCDGLPLAITVVGGLLLGKKELKSEWEKVLNSFNRNLSRSQSGVSAILELSYADLPPNLKFCFLYLGLFPEVSVISVPKLIHMWVAEGIMQKRDAENLEETAAYDDVERLCGRNMVQVVKTTVDARIKSCRVHDLLRELAIRKAEDENFFQIHDTRDGKISAKSRYLAVHSLPLDKNYFGTSIPPLRSLLFFNVHRENISLIFKSFRKLRMLDLENVEMGYNLPKEIGEVRLLRYLGLRRTSIGRLPHSFGCLRNLQTLDIRTTYVMKVSNIIWKLESLRHLYAYDMVCDVPLKIEGLSNLQTLLGIRFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G4Y626</accession>
    <name>G4Y626_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine proteinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CPI-2</name>
        <name evidence="7" type="ORF">GSCOC_T00030143001</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="BMC Plant Biol." volume="12" first="31" last="31">
            <title>Coffee cysteine proteinases and related inhibitors with high expression during grain maturation and germination.</title>
            <authorList>
                <person name="Lepelley M."/>
                <person name="Amor M.B."/>
                <person name="Martineau N."/>
                <person name="Cheminade G."/>
                <person name="Caillet V."/>
                <person name="McCarthy J."/>
            </authorList>
            <dbReference type="PubMed" id="22380654"/>
            <dbReference type="DOI" id="10.1186/1471-2229-12-31"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cystatin family. Phytocystatin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JF950586">
        <property type="protein sequence ID" value="AEQ54767.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4Y626"/>
    <dbReference type="STRING" id="49390.G4Y626"/>
    <dbReference type="Gramene" id="CDP09706">
        <property type="protein sequence ID" value="CDP09706"/>
        <property type="gene ID" value="GSCOC_T00030143001"/>
    </dbReference>
    <dbReference type="InParanoid" id="G4Y626"/>
    <dbReference type="OMA" id="WHRICFR"/>
    <dbReference type="OrthoDB" id="1908104at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000011">
        <property type="entry name" value="Cysteine proteinase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027214">
        <property type="entry name" value="Cystatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11413">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11413:SF116">
        <property type="entry name" value="MULTICYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16845">
        <property type="entry name" value="SQAPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEQ54767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="98" mass="10987" checksum="61702CE0CC8B61AA" modified="2011-12-14" version="1">MAKVGGISESKGNENSLEIESLAKFAVDDYNKKQNALLEFQKVINSKEQVVAGTVYYLTIEVKDGNEKKLYEAKVWVKPWLNFKEVQEFKPAAGDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q4QZT3</accession>
    <name>Q4QZT3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose synthase</fullName>
            <ecNumber evidence="3 8">2.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sus1</name>
        <name evidence="14" type="ORF">GSCOC_T00041507001</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Theor. Appl. Genet." volume="111" first="1032" last="1041">
            <title>Construction and characterization of a Coffea canephora BAC library to study the organization of sucrose biosynthesis genes.</title>
            <authorList>
                <person name="Leroy T."/>
                <person name="Marraccini P."/>
                <person name="Dufour M."/>
                <person name="Montagnon C."/>
                <person name="Lashermes P."/>
                <person name="Sabau X."/>
                <person name="Ferreira L.P."/>
                <person name="Jourdan I."/>
                <person name="Pot D."/>
                <person name="Andrade A.C."/>
                <person name="Glaszmann J.C."/>
                <person name="Vieira L.G."/>
                <person name="Piffanelli P."/>
            </authorList>
            <dbReference type="PubMed" id="16133319"/>
            <dbReference type="DOI" id="10.1007/s00122-005-0018-z"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DH200</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DH200</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + sucrose + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:76533"/>
            <dbReference type="EC" id="2.4.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.13" evidence="3 8"/>
    <dbReference type="EMBL" id="AJ880768">
        <property type="protein sequence ID" value="CAI56307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4QZT3"/>
    <dbReference type="FunCoup" id="Q4QZT3">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="49390.Q4QZT3"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP03035">
        <property type="protein sequence ID" value="CDP03035"/>
        <property type="gene ID" value="GSCOC_T00041507001"/>
    </dbReference>
    <dbReference type="InParanoid" id="Q4QZT3"/>
    <dbReference type="OMA" id="NNEHKFM"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016157">
        <property type="term" value="F:sucrose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1230:FF:000001">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.330:FF:000001">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000004">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth_GT-B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012820">
        <property type="entry name" value="Sucrose_synthase_pln/cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056736">
        <property type="entry name" value="SUS_EPBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056735">
        <property type="entry name" value="SUS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02470">
        <property type="entry name" value="sucr_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839:SF7">
        <property type="entry name" value="SUCROSE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="GT-B_Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24862">
        <property type="entry name" value="SUS_EPBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24861">
        <property type="entry name" value="SUS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sucrose synthase N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase EPBD" evidence="12">
        <location>
            <begin position="156"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase first GT-B" evidence="10">
        <location>
            <begin position="265"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="565"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAI56307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP03035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="806" mass="92597" checksum="5BA5AD98A7139B34" modified="2005-07-19" version="1">MAERVLTRVHSLRERLDATLAAHRNDVLLFMSRLETHGKGILKPHQLLAEFEEINKDGKQKIHDHAFEEVLKSTQEAIVLPPWVALAIRLRPGVWEYVRVNVHALVVEELTVPEYLHFKEELVDGSKNGNFVLELDFEPFTASFPKPTLTKYIGDGVEFLNRHLSAKMFHDKESMAPLLDFLRVHQYKGKTMMLNDRIKDLNTLQAVLRKAEEYLTTLSADTPYSEFEHKFQEIGLERGWGDTAERVLEMICMLLDLLEAPDSCTLEKFLGRIPMVFNVVILSPHGYFAQENVLGYPDTGGQVVYILDQVPALEREMLKRIKEQGLDVKPRILIITRLLPDAPGTTCGQRLEKVYGSEYSHILRVPFRTEKGVVRKWISRFEVWPYMETFTEDVAKEVTAELQAKPDLVIGNYSEGNLVASLLAHKLGVTQCTIAHALEKTKYPDSDIYLSKFDEKYHFSCQFTADLIAMNHTDFIITSTFQEIAGSKDTVGQYESHMAFTMPGLYRVVHGIDVFDPKFNIVSPGADTNLYYPHTEKEKRLTSFHPEIEELLFSDVENEEHLCVLKDKKKPILFTMARLDRVKNLTGLVELYAKNPKLRELVNLVVVGGDRRKESKDLEEQAEMKKMYSLIETYNLNGQFRWISSQMNRVRNGELYRYIADTKGAFVQPAFYEAFGLTVVEAMTCGLPTFATNHGGPAEIIIHGKSGFHIDPYHGEQVSELLANFFERCKKEPSYWDTISAGGLKRIQEKYTWQIYSDRLLTLAGVYGFWKCVSKLDRQEIRRYLEMFYALKYRKLAEAVPLAVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM85</accession>
    <name>A0A068TM85_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00014641001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in the defense reaction of plants against pathogens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM85"/>
    <dbReference type="STRING" id="49390.A0A068TM85"/>
    <dbReference type="Gramene" id="CDO97326">
        <property type="protein sequence ID" value="CDO97326"/>
        <property type="gene ID" value="GSCOC_T00014641001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM85"/>
    <dbReference type="OMA" id="EHAMIAR"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM85"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05381">
        <property type="entry name" value="CAP_PR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000006">
        <property type="entry name" value="Putative pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656873" description="SCP domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="8">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO97326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="161" mass="17720" checksum="E89738699969FD59" modified="2014-10-01" version="1">MGLFKFSLVLLITLASSPSFLAQNTQKDYVDAHNAARAQVGVGPMHWDEQVAAYARNYAAKIQMANTCNNLVHSGGRYGENLAAGTGDFTGLRAVNLWVGEKSKYNYQTNSCVGGVCGHYTQVVWRSSVRLGCARVRCNNGWWYVICSYDPRGNIGGQRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNY6</accession>
    <name>A0A068TNY6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00015108001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNY6"/>
    <dbReference type="Gramene" id="CDO97697">
        <property type="protein sequence ID" value="CDO97697"/>
        <property type="gene ID" value="GSCOC_T00015108001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNY6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO97697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="83" mass="9649" checksum="BF3380F7B9E8FE45" modified="2014-10-01" version="1">MRLVARKRGNKFGKIFVVNRELFVLKLPVLDLNYLNLVTYTHKLRSLGCMQMTGLSGWLYNSLQESCSLENMQRKIILELCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQN6</accession>
    <name>A0A068TQN6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00022405001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQN6"/>
    <dbReference type="FunCoup" id="A0A068TQN6">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQN6"/>
    <dbReference type="Gramene" id="CDO98342">
        <property type="protein sequence ID" value="CDO98342"/>
        <property type="gene ID" value="GSCOC_T00022405001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQN6"/>
    <dbReference type="OMA" id="IHAFLYA"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000119">
        <property type="entry name" value="Protection of telomeres 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057620">
        <property type="entry name" value="POT1A/B-like_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25507">
        <property type="entry name" value="OB_POT1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="8">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO98342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="463" mass="53452" checksum="893EBBDFAFB1964E" modified="2014-10-01" version="1">MGRRDDYRFLQLIDAIASINQKVNLIGVVIETSIPKQSKGTDCFCTIRIVDESKPGPGIAINFFAENMEKLPQVMAAGDIIQLSHVVMKMHGSEVYAVFNKKFSSFALFEGKHGRSFVPYQFSATYHAREQDKKFILELRKWLIEHPNETGSRDLPSLKEIREGEHFNLACKILHLCEVKKDEWILFVWDGTDTPPALVEPKFEDEKEDPLPLQLEPFPLPRDVLCTFPAVGTVLRVIIRRGNEKLDLNVLKSGRWVKFVNLKCESHAALWCAFIMPFTKICYLPDDDDIILQRQRSYDERISSKWGRMPLSCFPWPSDLTETDHPDVPFVTLMHVLTNPEVTSKFRCVVRVVAVFPWRVEDFYSPVGAYRIRLTLEDATARIHAFLYADDAVNFFGGYYPVDVMTRKRNTLLGIPESDDGREMKDGFRNPPWMQCCLKSYYVDKGDPWGSRNYRMFATRLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRQ7</accession>
    <name>A0A068TRQ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LEC14B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025914001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat LEC14B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRQ7"/>
    <dbReference type="STRING" id="49390.A0A068TRQ7"/>
    <dbReference type="Gramene" id="CDO98941">
        <property type="protein sequence ID" value="CDO98941"/>
        <property type="gene ID" value="GSCOC_T00025914001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRQ7"/>
    <dbReference type="OMA" id="WADALFI"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000492">
        <property type="entry name" value="LEC14B homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO98941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53540" checksum="441A8921B1F53E5A" modified="2014-10-01" version="1">MTWTRKRLDGCDRGNGAEGSSGRQRISEENSYLNHEIALLTKYTSTAHERFRKVVPGKARLPVSPVQMLVGREGNYSGRGRFSSGDCCHVLSRYMPINGPSVVDRMPSGAYVSQFSEDGSLFVAAFQESQIKIYNVDKGWRLQKDIRARSLRWTITDTSLSPDRRFLAYSSISPIVHIVDVGSAATESLANVTEIHEGLEFSSDASDYDDYSFGIFSVKFSTDGRELVAASSNNSIYVYDLEAKRLSLCIPAHESDVNAVCFADETGHLIYSGSDDCLCKVWDRRCFATKGKPAGVLIGHLEGITFIDTRGDGRYLISNGKDQVIKLWDIRKMSSNADYVQWRRDYDWDYRWMDYPERAKNLRNPNDLSLTTYKGHTVLRTLIRCYFSPAHSTGQKYIYTGSTDSIVYIYDLVSGAQVAKLDFHEGPVRDCNWHPYYPMFVSSSWDGVLANWEFPGNGVPTRRNRRRRRALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRX5</accession>
    <name>A0A068TRX5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FRIGIDA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00026079001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Frigida family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRX5"/>
    <dbReference type="STRING" id="49390.A0A068TRX5"/>
    <dbReference type="Gramene" id="CDO99060">
        <property type="protein sequence ID" value="CDO99060"/>
        <property type="gene ID" value="GSCOC_T00026079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRX5"/>
    <dbReference type="OMA" id="PMIREPY"/>
    <dbReference type="OrthoDB" id="685090at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRX5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012474">
        <property type="entry name" value="Frigida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791:SF2">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN 4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07899">
        <property type="entry name" value="Frigida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4 5" id="KW-0287">Flowering</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO99060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="24901" checksum="211A5941B5BE4F5D" modified="2014-10-01" version="1">MPKLAVSLGLADKMPDIIEELISRGQQVDAVHFIFEVDLVDEFPPVPLLKAFLKDAKKLATSILGDPNNTGRAAHMAAKKEQSAIRAVIKCIEEYKLEAEFPPENLKKRLEQLEKTKTEKRKPVVVPANKRTRASNGEHVPPAKAGRLTNAYVSSFPAAPTFVRSPSHSPYHAGVPAYPSPPAIYGHGSRSPSPYVYSPEAYPGAPVTYPAYGGYGSPMAPAYQQPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS21</accession>
    <name>A0A068TS21_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">soluble epoxide hydrolase</fullName>
            <ecNumber evidence="2">3.3.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00025771001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Epoxide hydrolase involved in the biosynthesis of cucurbitacin and mogroside tetracyclic triterpene natural products (e.g. siamenoside I and mogrosides IV, V and VI). Cucurbitacins have cytotoxic properties and exhibit deterrent taste as a defense barrier against herbivores. Mogrosides are nonsugar highly oxygenated compounds used as high-intensity zero-calorie sweeteners; they also possess pharmacological properties such as regulating immunity, lowering blood sugar and lipid levels, protecting the liver, and acting as antioxidants and antitumor agents. Catalyzes the hydrolysis of aromatic epoxide-containing substrates, such as the conversion of 24,25-epoxycucurbitadienol to 24,25-dihydroxycucurbitadienol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(24S)-24,25-epoxycucurbitadienol + H2O = (24R)-24,25-dihydroxycucurbitadienol</text>
            <dbReference type="Rhea" id="RHEA:81855"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:229949"/>
            <dbReference type="ChEBI" id="CHEBI:229950"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:81856"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19038"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="2"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS21"/>
    <dbReference type="STRING" id="49390.A0A068TS21"/>
    <dbReference type="Gramene" id="CDO98837">
        <property type="protein sequence ID" value="CDO98837"/>
        <property type="gene ID" value="GSCOC_T00025771001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS21"/>
    <dbReference type="OMA" id="QVEASHW"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS21"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000161">
        <property type="entry name" value="Epoxide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="27"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO98837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="329" mass="36994" checksum="F9D0CBB67E621200" modified="2014-10-01" version="1">MEKIEHKNVEVNGINMHVAEIGQGPVVLFLHGFPECWYTWRHQMSFMASHGHRAVAPDLRGFGGTTGAPIDDPSKFTTLHVVGDIIELLKIVAPDEDKVFLVGHDWGAVMAWALCLYRPDKVKALFNMSVSFGPRNPKRKPIETLRAVCGPDYYVCRFQEPGEIEEEFAKVGTKRVLENFLSYRAPGPLFLPKGILFGDSPDAPTTLPSWLSEEDVAYYVNQYAQSGFTGALNYYRALDINWELTAPWTGAQVKVPVKFVVGDLDLTYNAPGTKDYLHKGGLKKDVPFLDQVVVMKEVGHFLHEEKPDEINKYIHQFIQKVSSPICSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSF9</accession>
    <name>A0A068TSF9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025875001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSF9"/>
    <dbReference type="STRING" id="49390.A0A068TSF9"/>
    <dbReference type="Gramene" id="CDO98914">
        <property type="protein sequence ID" value="CDO98914"/>
        <property type="gene ID" value="GSCOC_T00025875001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSF9"/>
    <dbReference type="OMA" id="KEMSHIC"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSF9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19907">
        <property type="entry name" value="DSRM_AtDRB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19908">
        <property type="entry name" value="DSRM_AtDRB-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000036">
        <property type="entry name" value="Double-stranded RNA-binding protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044450">
        <property type="entry name" value="AtDRB-like_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044451">
        <property type="entry name" value="AtDRB-like_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46031:SF26">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="594" mass="65966" checksum="ABB63119A79043D9" modified="2014-10-01" version="1">MYKNQLQEFAQRSCINLPSYTSIREGPDHAPRFKAKVNCNGEIFESPKFCCTLRQAEHAAAEVALRMLSQRGPSRAVAAKVLDETGVYKNLLQETAHRAGMKLPVYTTVRTGPGYAPVFTCTVELAGMSFSGEPAKTKKQAQKSAAMAAWFSLKEMSHICSSSYHLSDLGRKDEQEQVIVARYLSSLRLPEMSISGQGEKGKLRKEIFRVKGNVIPCGVGSPSFRMKHQNSTYSYLPPEWFLYETCHRGVPQQSHFLALPSTSTSIPRPRFFPFIQSMMLRPDIGSIFWAREQEPIAVVPEPRPLFYLSNNLLPVPDRNDSRVTIEEIEENSPMQEGWLNKDVNPSCWRDNFLSSASGIPTLDVSNDPQSQHSSLEEELLQKETGERQVQSTNGTSKSIWPIKPNKEFSWLPPGFMCNRQSVTEAGEAWLQPQNIKSPGFLWSDVQHLHSKVASCPKDTRHSAGLTTVSGVTGRNGGAFSSASFRPVVSNRSLPVSTPRNAVFTGSTRPRVECKMKHSHPKPCASQMAPAVQIRTVMPVRSSPTRRMPSPSQEGTSSEGEIKSAEVTGKDISTASSEFFLRKLQDSCTLHIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSG8</accession>
    <name>A0A068TSG8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00025887001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSG8"/>
    <dbReference type="FunCoup" id="A0A068TSG8">
        <property type="interactions" value="1270"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSG8"/>
    <dbReference type="Gramene" id="CDO98924">
        <property type="protein sequence ID" value="CDO98924"/>
        <property type="gene ID" value="GSCOC_T00025887001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSG8"/>
    <dbReference type="OMA" id="RTWRISC"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSG8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044813">
        <property type="entry name" value="ACP_chloroplastic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46153">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46153:SF20">
        <property type="entry name" value="ACYL CARRIER PROTEIN 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO98924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="137" mass="14515" checksum="A318E1DCC9B4A740" modified="2014-10-01" version="1">MASITGSFTSLSCSLMPNQAVNRVSKLGSVSLSISGKSFPSLRVQPARFRVSCAAKPETVDKVCKIVRKQLALPDESEVAGHSKFASLGADSLDTVEIVMGLEEEFGISVEEESAQNIATVQDAADLIEKLIENKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTA0</accession>
    <name>A0A068TTA0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00026331001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTA0"/>
    <dbReference type="FunCoup" id="A0A068TTA0">
        <property type="interactions" value="3576"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTA0"/>
    <dbReference type="Gramene" id="CDO99247">
        <property type="protein sequence ID" value="CDO99247"/>
        <property type="gene ID" value="GSCOC_T00026331001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTA0"/>
    <dbReference type="OMA" id="WHGARTE"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTA0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000164">
        <property type="entry name" value="Casein kinase 1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDO99247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="442" mass="50250" checksum="9A6122EC16C8C683" modified="2014-10-01" version="1">MDHVIGGKFKLGRKIGSGSFGELYLGVNVQTGEEVGVKLEPLKTKHPQLHYESKLYMLLQGGTGVPHLKWFGVEGEYSAMVIDLLGPSLEDLFNYCNRKFTLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPIEVLCKSHPSEFISYFHYCRSLRFDDKPDYSYLKRLFRDLFIREGYQFDYVFDWTVLKYPQIASSSRAVKNPVRQEVRDKYESFGRRNSSGAGLHGDPLRHRASEDVPSSKEVLTDSERGRVARTGSTSKRAVASSSRPNSSSEPNENRPGRLGSSGTGRLSTTQRLQPGFESKSSSFTRVAALRGGRDDTLRSFELLTIGSGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU98</accession>
    <name>A0A068TU98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monocopper oxidase-like protein SKU5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00029505001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU98"/>
    <dbReference type="STRING" id="49390.A0A068TU98"/>
    <dbReference type="Gramene" id="CDO99811">
        <property type="protein sequence ID" value="CDO99811"/>
        <property type="gene ID" value="GSCOC_T00029505001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU98"/>
    <dbReference type="OMA" id="FGIGDWT"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF311">
        <property type="entry name" value="MONOCOPPER OXIDASE-LIKE PROTEIN SKU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="110"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="341"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO99811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54966" checksum="150B2E3962FCB262" modified="2014-10-01" version="1">MFPGPLINATTNDFVHVNVFNDLDEPFLITWNGIQQRLNSWQDGVSGTNCPILPGTNWTYVFQTKDQIGTFTYFPSINFQKVAGGFGPIRVNNRVVISVPFGKPEAEFDLLIGDWFNVDYRVIRSSTQRKFPLYGAVPDVMLMNGNGPYGHPDSKTHESFTVTKGKTYRFRISNVGSFFSFNFRIQNHQMVLVETEGSYTNQVVLESLDVHVGQSYSVLVTADQDESDYYMVATPKLLNASDGSPLVAKGLLHYANSANTVSGPLPSGPDPYDIDFSVGQAKSIRWNLTTGAARPNPQGTFNITNITLSQTFILHGSLTEIDGLPRFAVNNVSYLAPNTPLKLADEFVNGSGVYQLDVFPTQSINDAAACGASVVSGIHKGWLEIVLKNDLGIVDSWHLDGFGFYVVGFGEGDWTPESRASYNLFDPVVRSTVQVYPQRWTAVYVFLDNPGMWNLRSEHLKNWYLGQELYIRVNDPDPNPGKENPPPENVLLCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUY4</accession>
    <name>A0A068TUY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029451001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUY4"/>
    <dbReference type="FunCoup" id="A0A068TUY4">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUY4"/>
    <dbReference type="Gramene" id="CDO99764">
        <property type="protein sequence ID" value="CDO99764"/>
        <property type="gene ID" value="GSCOC_T00029451001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUY4"/>
    <dbReference type="OMA" id="YAMMLDM"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000936">
        <property type="entry name" value="Arsenical pump-driving ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF0">
        <property type="entry name" value="ATPASE GET3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="7">
        <location>
            <begin position="72"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="400" mass="43456" checksum="83462F1787AC3356" modified="2014-10-01" version="1">MATKVVGSYPHSLKSLSSPLYLLKFNPSFSSGFVSFPSTRNQPRKSLVVRSVAAPAEAASGFDEMVSGTQRKYYMLGGKGGVGKTSCAASLAVKFANNGHPTLVVSTDPAHSLSDSFAQDLTGGTLIPVEGPYSPLFALEINPEKAREEFRSAGQKSGGTGIKDFMDGMGLGVLADQLGELKLGELLDTPPPGLDEAIAISKACFRVMQFLESQEYNMFTRIVFDTAPTGHTLRLLSLPDFLDASIGKILKLRQKIASATSAIKSVFGQEDSHREDAADKLERLRERMIKVRELFRDTSSTEFVIVTIPTVMAISESSRLCASLKKESVPVKRLIVNQVIPPSASDCKFCAMKRKDQMRSLNMIQSDPELSSLMVIQAPLVDVEIRGVPALQFLGDIVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVA9</accession>
    <name>A0A068TVA9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029639001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVA9"/>
    <dbReference type="FunCoup" id="A0A068TVA9">
        <property type="interactions" value="3035"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVA9"/>
    <dbReference type="Gramene" id="CDO99919">
        <property type="protein sequence ID" value="CDO99919"/>
        <property type="gene ID" value="GSCOC_T00029639001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVA9"/>
    <dbReference type="OMA" id="LFITWNK"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVA9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000001">
        <property type="entry name" value="AMME syndrome candidate gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="24071" checksum="A4AB57A578350430" modified="2014-10-01" version="1">MVSANREMVVFCFDTLVAHYNSEEAPPPAFDEGQHPLFVTWKKVINGGEPRLRGCIGTLEARCLINGFKDYALTSALRDKRFPPIQAKELPYLECTVSILTNYETAQHYLDWEVGKHGIIIEFTDPDYNTRRSATYLPEVAAHEGWTKTEAIDSLIRKAGYNGSITESLRKRIRLTRYQSTLFTMHFSDYVTYVKTTRGSAPAINGVKSGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWH9</accession>
    <name>A0A068TWH9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00032664001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWH9"/>
    <dbReference type="FunCoup" id="A0A068TWH9">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWH9"/>
    <dbReference type="Gramene" id="CDP00650">
        <property type="protein sequence ID" value="CDP00650"/>
        <property type="gene ID" value="GSCOC_T00032664001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWH9"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWH9"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009851">
        <property type="term" value="P:auxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052544">
        <property type="term" value="P:defense response by callose deposition in cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009630">
        <property type="term" value="P:gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000107">
        <property type="entry name" value="Tryptophan synthase alpha chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406:SF1">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE ALPHA CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE, ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0073">Auxin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="272" mass="28896" checksum="540F0D12065037A9" modified="2014-10-01" version="1">MATIITDQAVGLSETFSKLKKQGKVALITYITAGDPDLSTTAEALKVLDACGSDIIELGVPYSDPLADGPVIQAASTRSLARGTNFDKIISMLKDVIPRLSCPIALFSYYNPILKRGVEKFMITVRDAGIHGLVVPDVPLEETEILRKEATKYNLELVLLTTPTTPTARMKAIAKASEGFLYLVSSVGVTGARASVSNHVQSLLTDVKKATNKPVAVGFGISKPEHVKQVAGWGADGVIVGSAMVRILGEAKSPEEGLKELESFTKSLKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWL0</accession>
    <name>A0A068TWL0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00008663001</name>
        <name evidence="11" type="ORF">GSCOC_T00032252001</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DH200</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DH200</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG744978">
        <property type="protein sequence ID" value="CDP21702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWL0"/>
    <dbReference type="FunCoup" id="A0A068TWL0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00344">
        <property type="protein sequence ID" value="CDP00344"/>
        <property type="gene ID" value="GSCOC_T00032252001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP21702">
        <property type="protein sequence ID" value="CDP21702"/>
        <property type="gene ID" value="GSCOC_T00008663001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWL0"/>
    <dbReference type="OMA" id="HERIILI"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF132">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MPSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP00344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="232" mass="25535" checksum="4C0484FC6A3BCE4A" modified="2014-10-01" version="1">MASETEEFSESSSVIERLINSRNRDLALFLPFILAMTNSPNTPNPVQDSSTPDQEAQQSPPNMRESTDRIILINPLTQGMVVIEGSRGSGSSSSSLESLLRDLFSKDGQPPASKASIEAMPMVEVKEDSEECVICLEEWEAGALAKEMPCKHRFHGECIEKWLRIHGSCPVCRHKMPVEENDDKSLKNGDAGGTRREIWVSFAYSNSNLDRRSEGINQGGSNDSGDSSQTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXK0</accession>
    <name>A0A068TXK0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034533001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXK0"/>
    <dbReference type="FunCoup" id="A0A068TXK0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXK0"/>
    <dbReference type="Gramene" id="CDP01040">
        <property type="protein sequence ID" value="CDP01040"/>
        <property type="gene ID" value="GSCOC_T00034533001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXK0"/>
    <dbReference type="OMA" id="GLENVCS"/>
    <dbReference type="OrthoDB" id="780193at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXK0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008889">
        <property type="entry name" value="VQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039609">
        <property type="entry name" value="VQ_15/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33179:SF58">
        <property type="entry name" value="OS08G0409500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33179">
        <property type="entry name" value="VQ MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05678">
        <property type="entry name" value="VQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VQ" evidence="2">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="434" mass="45593" checksum="97EEB5ADAE0A4C86" modified="2014-10-01" version="1">MDSGNSGSMQSSSGGDEEYESRSESISSFLNPSAHFGSISDHPQASVPQLLPHQPTSTLFHPHSQNSLDAFPQSLLANNPSGGNTNTTSTQYGSNHDLVWPRGLRSEANYANFGNVTASSSTQSVLAGGVQGLNSQSPSMLPSLGIEATKNDAKASLLQSADQQQPANVVKNPKKRTRASRRAPTTVLTTDTTNFRQMVQEFTGIPTAPFSAAASPFSRRLDLFSAGAASNLRAAGHLADSLGSLYPLRPSAQKMVHLSPFGTSSHTMIDALVSSTTTNAAGNIPNIPSAGGGNSSNTVLPPDHLGLPKQPQNLLNMQNQMLSIQPLLLNKHQPSAALATKNQGNTSHVPSFDELGLGHHPDHHQNVNANLSGWKDGGGTLNASQENLGGSSQHISNYKFNCSASTSEFQHDKGLENVTSAGEGTVGSWICPSD</sequence>
</entry>
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    <accession>A0A068TXP9</accession>
    <name>A0A068TXP9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034527001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXP9"/>
    <dbReference type="FunCoup" id="A0A068TXP9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TXP9"/>
    <dbReference type="Gramene" id="CDP01036">
        <property type="protein sequence ID" value="CDP01036"/>
        <property type="gene ID" value="GSCOC_T00034527001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXP9"/>
    <dbReference type="OMA" id="TRHYLMR"/>
    <dbReference type="OrthoDB" id="1693699at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044809">
        <property type="entry name" value="AUF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31215">
        <property type="entry name" value="OS05G0510400 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="38701" checksum="E47B4B69A9DB9100" modified="2014-10-01" version="1">MEINVKHPAYGFDQSDGFDSIPDPIVLHIFSKISDIKTLIRCRSVSKRFNSLVPQADSLLLRVDRVISTTDSDDDDGDSFFIAFLRSIVKSLHNFISPNKHTHFGSPTRTQNSPTQILRGFENIRSLQIELPSGDLRLEIGTTIKWKAHFGKTLKSCVILGFRGGSEADFSGGGLKMRVVWTISALIAASARHYMMLDVIREQTDLSNLVVKDKDNEGMVVMDKGGLKECRERGGEEEEMNNNNNNSNNNRRAGVWWKSNRTTVPAVRMRMRHEARMELSNGVKLEGATLVVVRPINASGCGGRGGGSEAEEQSGDVGLAMGAFGGDGVYGEAIERLLKCRSYILEMNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZK1</accession>
    <name>A0A068TZK1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036575001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZK1"/>
    <dbReference type="Gramene" id="CDP01502">
        <property type="protein sequence ID" value="CDP01502"/>
        <property type="gene ID" value="GSCOC_T00036575001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZK1"/>
    <dbReference type="OMA" id="SHRIEHK"/>
    <dbReference type="PhylomeDB" id="A0A068TZK1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="16216" checksum="506601D0C39C2FB3" modified="2014-10-01" version="1">MGIIFQVIYDCTQSHRIEHKIAFIYIFYPTLPSFVCQIDLSSELVKVLSNNRLKSATHRVYRMEGTERDSFAFFYSLKPGKWVEPLPQFTTEIGEPPKYRGFLYDDYMQLRRRDYTDNQPDKYEDIARITYYAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1L4</accession>
    <name>A0A068U1L4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039344001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1L4"/>
    <dbReference type="Gramene" id="CDP02064">
        <property type="protein sequence ID" value="CDP02064"/>
        <property type="gene ID" value="GSCOC_T00039344001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1L4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="8100" checksum="1F4333298A0E7A58" modified="2014-10-01" version="1">MKTDLTLIRGINLANSSLTDDTEIIQTNQLNYTNLFLDLYLYTGFLFFFFWVSSPSQPLSYWRTGQDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U206</accession>
    <name>A0A068U206_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00036740001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U206"/>
    <dbReference type="FunCoup" id="A0A068U206">
        <property type="interactions" value="1267"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U206"/>
    <dbReference type="Gramene" id="CDP01633">
        <property type="protein sequence ID" value="CDP01633"/>
        <property type="gene ID" value="GSCOC_T00036740001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U206"/>
    <dbReference type="OMA" id="YGCATPK"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U206"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF10">
        <property type="entry name" value="BIFUNCTIONAL PROTEIN FOLD 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="12">
        <location>
            <begin position="80"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="13">
        <location>
            <begin position="216"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP01633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="368" mass="40374" checksum="BBE4F2D512C93DC1" modified="2014-10-01" version="1">MMWRRMLSVTIAGERWLRRRNCLPSGIRVLCTLKTDHAYRSLKSPSLVSLDIPDIWDSNIVCSDFHSFQASFNRNMGRRIDGLLVAEEIRFGIATEVSRMKASIGEVPGLAVIVVGQRRDSQVYVRNKIAACEEVGIKFVLTELPDNCTEDEILNALTGFNKDSSIHGILVQLPLPRHLDEGRILDAIRLEKDVDGVHPLNMGNLAMHGREPLFIPCTPKGCVELLLRSDVEIMGKRAVVIGRSNIVGLPASLLLQRYHATVSIVHPFTKNPENIAREADILVAAAGVPNVVRGSWIKPGAIVIDVGTNPIEDPSCENGYRLIGDVCYEEAVKVASAVTPVPGGVGPMTVAMLLFNTLESARRALSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U275</accession>
    <name>A0A068U275_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040094001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U275"/>
    <dbReference type="Gramene" id="CDP02640">
        <property type="protein sequence ID" value="CDP02640"/>
        <property type="gene ID" value="GSCOC_T00040094001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U275"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="60" mass="6263" checksum="86846652540F7899" modified="2014-10-01" version="1">MSRRPSNPARRSTATGISGASFRPKSRPSSLLSVVLGALGVILVVGYLFRGSGNSLFAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2C7</accession>
    <name>A0A068U2C7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039690001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2C7"/>
    <dbReference type="FunCoup" id="A0A068U2C7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2C7"/>
    <dbReference type="Gramene" id="CDP02329">
        <property type="protein sequence ID" value="CDP02329"/>
        <property type="gene ID" value="GSCOC_T00039690001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2C7"/>
    <dbReference type="OMA" id="MCDMNPP"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2C7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000025">
        <property type="entry name" value="putative methylesterase 11, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF872">
        <property type="entry name" value="METHYLESTERASE 11, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="379" mass="41574" checksum="E6C198ACE3F65505" modified="2014-10-01" version="1">MGLCFSRRATVRKKQSRRLTNQSSSSAGNGGSNRWSRIRSTKKEEPIIHERALAAAILLQQELQNSGAAAAAPFDRSTSLRYPNGGSAKRNQTLPRSSSSRARSLTDPLLHPQQLLNQDVKLEGLETNHFVLVHGGGFGAWCWYKSIALLEEAGFKVTAIDLTGSGVHSFDTNCITSLSQYVKPLCDFLEKLADGEKVILVAHDFGGACLSYSMELYPSKVSKAVFIAAAMLTSGQSTLDMFSQKTDSNDLMRQAQIFLYANGNGHPPTAIDLDKSLLRDLLFNQSPSKDVALASVSMRPIPFLPVLEKLCLSDAKYGTVRRFYIETPDDNAIPISVQESMVSKSPPEKVFRLKGADHSPFFSKPQALHKLLVEISKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2R2</accession>
    <name>A0A068U2R2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NPH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00040028001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2R2"/>
    <dbReference type="FunCoup" id="A0A068U2R2">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2R2"/>
    <dbReference type="Gramene" id="CDP02592">
        <property type="protein sequence ID" value="CDP02592"/>
        <property type="gene ID" value="GSCOC_T00040028001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2R2"/>
    <dbReference type="OMA" id="MTHISRT"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2R2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18312">
        <property type="entry name" value="BTB_POZ_NPY3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043454">
        <property type="entry name" value="NPH3/RPT2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027356">
        <property type="entry name" value="NPH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32370">
        <property type="entry name" value="OS12G0117600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03000">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51649">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NPH3" evidence="6">
        <location>
            <begin position="211"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69620" checksum="9E5E9AD1152BF75E" modified="2014-10-01" version="1">MKFMKLGSKPDQFQTDGDNIRYVATELATDMVITVGEVKFYLHKFPLLSKSSRLQKLAANSNEENSDDINIDDIPGGPAAFEICAKFCYGMIVTLNAYNVVAARCAAQYLEMHETVEKGNLIYKIDVFLTSSIFRSWKDSIIVLQTTKSLNPWSEDLKIVSHCLDSIASKASIDASKVEWSYTYNRKKLPSENGNDTHWNGVRKQQLVPKDWWVEDLCELQIDMYKRVITTIRSKGRVSADVIGEALKAYILRRLPGFSKGLIQEADLVKCHYLVDTITWLVPREKNSVSCSFLLRLLQASIILECGENGRKELMKKIGQQLEEATVADLLIQAPSGETTPYNVELVRDLVEQFLIQEPDGHNDCPADNEFREISHGDVSDASRVKVARLVDCYLAEAARDCSLPLSKFVELAEMVSGFPRPTHDGIYRAIDVYLKEHPEITKSERKRICRLMDCRKLSVDASAHAVQNERLPLRVVVQVLFFEQVRSTTSSAGDSIPELAGSIKALLPGGSHASSRSATTNTEDDWDAVPTAEDLKALKGGLANIRLKEETEHGNDSNLAKINSEKVAMTKVKGLIMSKKIFSKLWSNKERDSENSSSDTSESPASSTAEETKSTPSRSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2Z6</accession>
    <name>A0A068U2Z6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00041353001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glutamate-gated receptor that probably acts as non-selective cation channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2Z6"/>
    <dbReference type="STRING" id="49390.A0A068U2Z6"/>
    <dbReference type="Gramene" id="CDP02930">
        <property type="protein sequence ID" value="CDP02930"/>
        <property type="gene ID" value="GSCOC_T00041353001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2Z6"/>
    <dbReference type="OMA" id="RLENRWW"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2Z6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13686">
        <property type="entry name" value="GluR_Plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19990">
        <property type="entry name" value="PBP1_GABAb_receptor_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000054">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000081">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044440">
        <property type="entry name" value="GABAb_receptor_plant_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017103">
        <property type="entry name" value="Iontropic_Glu_rcpt_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34836">
        <property type="entry name" value="OS06G0188250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34836:SF7">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037090">
        <property type="entry name" value="Iontro_Glu-like_rcpt_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="16">
        <location>
            <begin position="394"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="808"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="867"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="882"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP02930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="898" mass="100499" checksum="B764503654A6167D" modified="2014-10-01" version="1">MIDLCMSMALSDFYSIHSNYKTRLFLHTESAEEELDVASAVLEMLKNQEVHGVLGPEWSKEATFVVELGARAHVPVISFTAKNRAFSHSPSPYFVRTTPDDLYQVKSLTAICQGFEWHEVVILYEDTEYGNLFFSKLSKAFQEVDIQLSYISAISTSAEDVYITKELNKLMTKQTRVFLVHMNILLGNRLFNLARKAGMMSEGYAWLITDSLSNSLSSVDTASMEGVLGLRPHVPKSKNLNNFRAKWKRNALLRKPQSEIMDLNVYGLWAYDTVWALALAIEKSLSPDSDLLKSSQGDDRSDISNITISQFGSRILAELLYTKFTGLCGEFKLVDGQLQTSAFEIINLIGTGYRTVGYWSPDGGISGKLASTAIMWPGDTIVTPKGWSIPTTGKIKVGVPKKSEFTEFTNIQKDPVTNQFNFSGLSIDVFLASLKLLPFKLDYEFIPYLNTSTGLNGSYDHMLHKILDKTYDFVVGDVTILANRSTFIDFTLPYTESGVVMVVKNKKNIDMWIFLKPLRWDLWLTIVLACIFIGFVVRMLEHQRNNTNTGSLTPNEQPFGLFFWFPIAALAFPERNMVANKWSMFVLVVWLFVAYILMQSYTAKLSAIFTVDQLNFAFSKDYYVGYQHASFVHEFLINELHLDASKLRSYSTIEEYHDAMCRGGKKGGIDAIYGEIPYMKLLINRYGSEYRIVGPTHKTDGFGFAFPMGSPLVIYFSRAILNVTQGATMNVIEQKNFGPGYAADQDSISQESPSLTAYNFGGLFIIILSASMIALFCSKTSIGQRFTAMISNCCHRCSRFLNSSGKESRVHSLSHRDATGDSPSEEANESEENNRNVSHGPGEVREAEVDVADISARQGEVHESNRTNENAASSGTSEIQLSESSNMQQPESSSSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U398</accession>
    <name>A0A068U398_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L23/L25 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00040081001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U398"/>
    <dbReference type="STRING" id="49390.A0A068U398"/>
    <dbReference type="Gramene" id="CDP02629">
        <property type="protein sequence ID" value="CDP02629"/>
        <property type="gene ID" value="GSCOC_T00040081001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U398"/>
    <dbReference type="PhylomeDB" id="A0A068U398"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000532">
        <property type="entry name" value="50S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20206" checksum="3E5E30C19BF1A110" modified="2014-10-01" version="1">MCLILKFRSLTINANQAKLLPTESESWNVAINTEAYFTKGPQSWKHALRAAARSSSDAEGGKNVQQLAEPSRPRLSRKERNPKCLSSSAAQKVMLDHFQIVKYPLITDLTMREMIENNTLTFVVDKRADKNNIKAAAKKMFKIQTEKVNTLVMPSGDKKAYLTLTPDQKAAEVAKKIKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3I2</accession>
    <name>A0A068U3I2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00039473001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3I2"/>
    <dbReference type="FunCoup" id="A0A068U3I2">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3I2"/>
    <dbReference type="Gramene" id="CDP02163">
        <property type="protein sequence ID" value="CDP02163"/>
        <property type="gene ID" value="GSCOC_T00039473001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3I2"/>
    <dbReference type="OMA" id="FWPDSVL"/>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3I2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46285:SF7">
        <property type="entry name" value="OS06G0238900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46285">
        <property type="entry name" value="PROTEINASE INHIBITOR I4, SERPIN (DUF716)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="340" mass="37511" checksum="57C642CAB5543284" modified="2014-10-01" version="1">MGLFTYTIAGGGFILIGAWESFVSSSECIRNTPPSPPLASHRAISGINNSSTQTKKAPPFSSSVTCLSISVLSFLFILNSLISISDALNSKDHVGFAFQLEVIAIALLFFLYSTLGLFTLLKISFQFPSAILNMLLLFAFGEEFLFFYVRRKDPSGVENRYYDLFLVPIGICLFCTILELKSPKSNYARLGRGVGLVLQGMWIVQMGFSFFSDLMMVHGCSLHGKSRGNYTIKCKGHPEYHRGRAIATLQFNCHLALLVTLIVVVYGIVCKKHGIRRDLLLYRPLGPEIEHLDGQPQFTLDSDDDLDDADQNGIKEVGSVEMQKAIVAVPASEVNGYGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6H9</accession>
    <name>A0A068U6H9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017463001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6H9"/>
    <dbReference type="FunCoup" id="A0A068U6H9">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6H9"/>
    <dbReference type="Gramene" id="CDP04155">
        <property type="protein sequence ID" value="CDP04155"/>
        <property type="gene ID" value="GSCOC_T00017463001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6H9"/>
    <dbReference type="OMA" id="SHCHPSH"/>
    <dbReference type="OrthoDB" id="1284989at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6H9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34124">
        <property type="entry name" value="F16B3.27 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34124:SF2">
        <property type="entry name" value="F16B3.27 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="191" mass="20668" checksum="9F4CEF49998694BF" modified="2014-10-01" version="1">MGFSISNSSSNESHSQHHTLKVFLFCNYILIGAASSCTFLTLSLRLIPSLCGFFLILLHILTIAGAISGCAAASSGAGKWYGTHMVSTVLTAIFQGSVSVLIFTRTSDFLGNLKSYVREDDAALILKLSGGLCVAIFCLEWVVLTLAFFLKYFVYADGDSNGGASGTNGMRRSAKVQDQEDLKDWPWPFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U773</accession>
    <name>A0A068U773_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00017704001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U773"/>
    <dbReference type="STRING" id="49390.A0A068U773"/>
    <dbReference type="Gramene" id="CDP04346">
        <property type="protein sequence ID" value="CDP04346"/>
        <property type="gene ID" value="GSCOC_T00017704001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U773"/>
    <dbReference type="OMA" id="NIMKHNI"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U773"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="383" mass="43049" checksum="BF74CDF26FA91073" modified="2014-10-01" version="1">MIHYVSLQNIMKHNISFDKSLVLLTLGGTENNLKNGTHLRELASQSVAKSQLLRAIMNIAPLAISTTGQGYSGVDLTSAVTSDQETEERRLEADAMVLADRGVVCIDKFDKMNDQDCVAIHEVTQQQTVTIAKAGIHASLNAQCSVVAAANPIYGTVRCRIYNIGLPHSLLSPFDLLFIVLDQMEPGIERHISEHVLQMHSFHSTMDRDKRSTVFVKYNPMLYGTKTSRKHETLTIDFLKKYIHYAKHRIQPELTDKPSDQIATAYAELRSTSPNAKTKAGTLPITARTLETIIHLSTAHPKFKLRSQINLYILKADVDAALQVLNFAIYHQKLTKMKEHKQEKERQNERKCRSENNASDTGRPHHQGARNDRENGDASDRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7J9</accession>
    <name>A0A068U7J9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017957001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7J9"/>
    <dbReference type="Gramene" id="CDP04530">
        <property type="protein sequence ID" value="CDP04530"/>
        <property type="gene ID" value="GSCOC_T00017957001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7J9"/>
    <dbReference type="PhylomeDB" id="A0A068U7J9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="86" mass="9101" checksum="51180F25D44218E3" modified="2014-10-01" version="1">MGNVNGREDGGDGNSPSGLDAEDGGEFMGQSPPPSPRASHSPLMFRPQAMSTFHVHMLPSVCTMSSQAKYAFLLSSLFLSKLSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7U0</accession>
    <name>A0A068U7U0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00017735001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 20">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7U0"/>
    <dbReference type="FunCoup" id="A0A068U7U0">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7U0"/>
    <dbReference type="Gramene" id="CDP04367">
        <property type="protein sequence ID" value="CDP04367"/>
        <property type="gene ID" value="GSCOC_T00017735001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7U0"/>
    <dbReference type="OMA" id="MTSDWMP"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7U0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000004">
        <property type="entry name" value="Chlorophyll a-b binding protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19 20" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5 20" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15 20" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 20" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11 20" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="18 20" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="8 20" id="KW-0934">Plastid</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 20" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP04367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="201" mass="22032" checksum="29CEBE02DFF8CBA8" modified="2014-10-01" version="1">MSAEWMPGEPRPPYLDGSAPGDFGFDPLRFGEVPENLERYKESELIHCRWAMLAVPGVLVPEALGLGNWVQAQEWAAIPGGQATYLGQPVPWGNLPTILAIEFLAIAFVEHQRSIEKDTEKKKYPGGAFDPLGFSKDPAKFAEYKVKEVKNGRLALLAVVGFAVQQSAYPGTGPLENLAAHLADPWHNNIGNVIIPRSIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA29</accession>
    <name>A0A068UA29_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00019966001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA29"/>
    <dbReference type="Gramene" id="CDP05049">
        <property type="protein sequence ID" value="CDP05049"/>
        <property type="gene ID" value="GSCOC_T00019966001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA29"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="7082" checksum="3E3AB668D2EF6E99" modified="2014-10-01" version="1">METTSSPAVVRITWKVASPFHCNRTFFHGLVERKTRPEKTTVSKVKAEKTMPQQIYMHQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCM5</accession>
    <name>A0A068UCM5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00020423001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCM5"/>
    <dbReference type="Gramene" id="CDP05398">
        <property type="protein sequence ID" value="CDP05398"/>
        <property type="gene ID" value="GSCOC_T00020423001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCM5"/>
    <dbReference type="PhylomeDB" id="A0A068UCM5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="71" mass="7845" checksum="6695E76992FC46C9" modified="2014-10-01" version="1">MLTSCTIKYALQYVRSLSILNAEGSESLDENMSAKKRRISVSTEEELGNSLERKDVADDFGEPGNSLSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD86</accession>
    <name>A0A068UD86_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00022870001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the auxin efflux carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD86"/>
    <dbReference type="STRING" id="49390.A0A068UD86"/>
    <dbReference type="Gramene" id="CDP06197">
        <property type="protein sequence ID" value="CDP06197"/>
        <property type="gene ID" value="GSCOC_T00022870001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD86"/>
    <dbReference type="OMA" id="YSMVNNG"/>
    <dbReference type="OrthoDB" id="1868374at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD86"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014024">
        <property type="entry name" value="Auxin_eff_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00946">
        <property type="entry name" value="2a69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF66">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="599" mass="64663" checksum="FBC1CCFD1E170BC7" modified="2014-10-01" version="1">MITITDLYHVLTAVVPLYVAMILAYGSVRWWKIFSPDQCSGINRFVALFAVPLLSFHFISTNNPYAMNYRFIAADTLQKIIVLVVLAIWSRTSSRGSLEWSITLFSLSTLPNTLVMGIPLLKGMYGDASGSLMVQIVVLQCIIWYTLMLFLFEYRGARMLIAEQFPDTAGSIISFKVDSDIISLDGKEPLQTEAEVGEDGKLHVTVRKSTSSRSEIFSRRSHGPNSGLSMTPRPSNLTNAEIYSLQSSRNPTPRGSSFNHTDFYSMVNGKNASNVSPRQSNFGNMNFDEENSLGGFGNLSRANGVSGQGNAGYPAPASAGIFSPVSGPGAKKKANGTDGGKDLHMFVWSSSASPVSEGGIHVFRGGDYGNDLGVGAHPKDYDDFGRDEFSFGNRPGANGDDREGPVLSKLGSSSTAELHPKASAQDIKATAMPPASVMTRLILIMVWRKLIRNPNTYSSLFGLTWSLVSFRWGIQMPAIIAKSISILSDAGLGMAMFSLGLFMALQPKIIACGKTVAAFSMAVRFLTGPAVMAASSIAVGLRGVLLHIAIVQAALPQGIVPFVFAKEYNVHPDILSTMVIFGMLIALPITLVYYILLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDD6</accession>
    <name>A0A068UDD6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00023390001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDD6"/>
    <dbReference type="FunCoup" id="A0A068UDD6">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDD6"/>
    <dbReference type="Gramene" id="CDP06511">
        <property type="protein sequence ID" value="CDP06511"/>
        <property type="gene ID" value="GSCOC_T00023390001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDD6"/>
    <dbReference type="OMA" id="SFWIRAI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDD6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF370">
        <property type="entry name" value="LACCASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104023" description="Laccase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="160"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="412"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="561" mass="61226" checksum="4B3215F8650C883F" modified="2014-10-01" version="1">MGGYSSSWVQILILALFLFPALVHCRVRHYKFDVVLKNFTRLCSSKPIVTVNGKFPGPTLYAREDDTVLVRVVNHVKYNVSIHWHGVRQLRTGWADGPAYITQCPIQPGQSYVYNFTITGQRGTLLWHAHILWLRATVHGAVVILPKRGVLYPFPKPHHENVVVLGEWWKSDTEAVINEALKSGMAPNVSDAHTINGHPGAVANCSSDQGGFTLSVEPGKSYLLRVINAALNEELFFKIAGHTLTVVEVDATYVKPFKTDTILVAPGQTTNVIVTADQSAGKYMVSASTFMDSTIAVDNTSATATLHYSGTLSSSPTTFTTAPALNATPVANKFTNSLRSLNSEKYPAQVPQTVDHSLFFVVSLGINPCPTCKAANGSRVVASVNNVTFVMPTVALLQAHFFNINGVFTTDFPGNPPSPFNYTGTPPANLQTKNGTKVYRLPYNATVQVVLQDTGIVAPENHPIHLHGFNFFAVGRGLGNFDPKTDPKKFNLVDPVERNTIGVPTGGWVAIRFRADNPGVWFMHCHLEVHTTWGLKMAFLVDNGKGTNESLLPPPSDLPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDN1</accession>
    <name>A0A068UDN1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDSL esterase/lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00020945001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739102">
        <property type="protein sequence ID" value="CDP05713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDN1"/>
    <dbReference type="FunCoup" id="A0A068UDN1">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDN1"/>
    <dbReference type="Gramene" id="CDP05713">
        <property type="protein sequence ID" value="CDP05713"/>
        <property type="gene ID" value="GSCOC_T00020945001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDN1"/>
    <dbReference type="OMA" id="CTNADKY"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDN1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000003">
        <property type="entry name" value="GDSL esterase/lipase APG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF46">
        <property type="entry name" value="OS06G0636700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654713" description="GDSL esterase/lipase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38598" checksum="84E0C35391823D4B" modified="2014-10-01" version="1">MAGIWVSWLFVIHFLIVQTSAKIPAIIVFGDSSVDSGNNNQIPTVARSNFEPYGRDFSGGQPTGRFSNGKIPTDFISEAFGLRPIVPAYLDPKYSISDFAIGVSFASAATGYDNLTSDVLGVIPFWKELEYYKEYQKRLKAYLSEQKANYTISEALYIISIGTNDFLENYYALSDRRSQYTIDQYQNFLAGIAKNFVTNLYHLGARKISLGGLPPMGCMPLERTTNIPNGEGCVQSYNNVAVSFNAKLNGLVSNLNTQLPGIQLVFSNPYYAMLNIISRPSAYGFEVASVACCATGMFEMGYACDRYNPFTCTDANKYVFWDSFHPTEKTNRIVSESVVKTVLSKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDW8</accession>
    <name>A0A068UDW8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD finger protein ALFIN-LIKE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00023342001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
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        <text evidence="11">Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.</text>
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        <text evidence="11">Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
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    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Alfin family.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="184"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="240" mass="27133" checksum="4A2D6A13337FE7F2" modified="2014-10-01" version="1">MSSVSSNPRTVEEIFKDYSARRAGIVRALTYDVDDFYGLCDPEKENLCLYGHPNETWEVNLPAEEVPPELPEPALGINFARDGMNRRDWLSLVAVHSDCWLLSVAFYLGARLNRNERKRLFSLINDLPTVFEVVTDRKPAKEKPSVDSGSRSRGGTKRSNDGQAKSNPRLADESYEEDDDEHSETLCGSCGGNYNADEFWIGCDICERWFHGKCVKITPAKAENIKQYKCPSCSLKRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEV2</accession>
    <name>A0A068UEV2_COFCA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="2 3">
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            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
    <sequence length="84" mass="9009" checksum="D925212E9662852C" modified="2014-10-01" version="1">MVVADPIVSQADNFLTMAWSITICFIEYARVSVTAKGKPSGIATTRIVTAAAMIRMMEFMISPVLVCLALNSLCPLSSLVCPVK</sequence>
</entry>
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        <lineage>
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            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
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                <person name="Garsmeur O."/>
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                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFQ5"/>
    <dbReference type="STRING" id="49390.A0A068UFQ5"/>
    <dbReference type="Gramene" id="CDP07029">
        <property type="protein sequence ID" value="CDP07029"/>
        <property type="gene ID" value="GSCOC_T00024116001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFQ5"/>
    <dbReference type="OMA" id="YLLRWTI"/>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFQ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="854"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1242" mass="134710" checksum="F283CE563CFE59B1" modified="2014-10-01" version="1">MDSPNPNSQPMRVLIRPPTPNPPPPSPPPPTPPDPSPTQNPTPIPSQQNGIVVVGFVGRRHGDVTQLINRVIDANVFGSGNLDTPFRFNKQELISEEIEEWFKLRCISYYFEEEKGILYLQFSSISCPIMDADLESQLGFDSLFEDREFGDLQGLLFMFSVSILVPYFYLAMQVCHVLILTQEGSRFDTQILKKFRVLQAAKHAMSPYFKSQSMQPLTPNSHASSSSRMFLSGASSNSPSPGRSRSILNRGAAVTLMSGLGSHSSLLPGQCYPVILFIFLDDFSDANPSSALGEQVEGSPLSQSSSSNNMARPNLPTKGSGSVVVLARPVNKPEGGFRKKLQSSLEAQIRFSIKKCRILSSSETGHAGTRSGGISSAAPLFLLDASKAVILVDLCSNHRGESLEFATRLVEDVIDGKATSDSLLLESNSQSANKEDILSVKEFILRQQSDILRGRGGMVTSTSSGPATGVGMVAVAAAAAAASAASGKTVSTPELPSLETWLSLSQPILHGILSVKPGYTGESEFSKRKPDQQYAAMPAVEGNAAKATDSLENAISILESGRGLCAKFSTLWCEKSLPIAKEIYLNELPPCYPTSRHEAHLERALVAFKSMVKGPAVQIYMKKLKDECTSIWSSGRQLCDAVSLTGKPCMHKRHSVGTDDLLVTDEIKPHSSGFVFLHACACGRSRQLRPDPFDFETANISFNCFPECDKLLPALHIPQGSVEGPIKPSCWRLIRVGGARYYNPAKGLLQSGFGTTQKFLLKWSIALGKQKISNGLSLSNQLQVYSNKLSGSDKDEPLAGKDTKKVGDAHFQAQEVQSEVEVPKRQPLLNNKASDKMMGVSNSTMRKPFSEVVAGSAGTHSGFPPLQTRKQPLPGSEKGIKQHDTREKGLSKAMEIANNQGSQKLPNIATIDHATNGVAINTNADANSDPLLQIGSNDVPLNMATGVKVREFIPLKHVSIYVGFEHECPHGHRFILTPDHLKGLGSPYAMPEESLVTSSIENSDHNMADSSKSGKNGGHARARKQSNGIINNAFRMTSNLEESKVRSTNKIVYENGQMQVSNILREQNLSEAKGTSSVMDLAAGFQSVNLDDGGTAFSLLNRSLPIYMNCPHCRESRKKKDTMNVKFASTISQLQRIFLVTPAFPVILAACPVVQFEDSCLPSTVPDCQEKLQFGLGCRVILPPDSFLSLRLPFVYGVKLDDGKVHPLTPFEDQPQLTAWITKGTTLQVVSQGSNLAGGAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFW9</accession>
    <name>A0A068UFW9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00024607001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFW9"/>
    <dbReference type="FunCoup" id="A0A068UFW9">
        <property type="interactions" value="901"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFW9"/>
    <dbReference type="Gramene" id="CDP07366">
        <property type="protein sequence ID" value="CDP07366"/>
        <property type="gene ID" value="GSCOC_T00024607001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFW9"/>
    <dbReference type="OMA" id="TKIGGWI"/>
    <dbReference type="OrthoDB" id="2017825at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFW9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35097">
        <property type="entry name" value="GDSL ESTERASE/LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35097:SF1">
        <property type="entry name" value="GDSL ESTERASE_LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47463" checksum="188A028394A0CBD4" modified="2014-10-01" version="1">MEPVASVVDKLKDFAKSSQELLARGILRWPQNFNRRNPIEILKRLQREAFSDIMKLRDRQDKVERMLTFYKTSKATPFQEASTRVRGDIDVVGAMFMVDNFDDQQHQTVQNAGIRTGVDLRLVFETAIREKDMLVAEFVAGRKDQGNTLERPLSLGKLLYSANVSDWFSAVAIPMGATCSDVAVDMSSFHKDKGFSEYSAYGPPFLNQKNGSALGIMVKKSNVVASLAQFVSGLGLPTNCSEITNCFGTFGQVVYQLSQTTKLSLLGVHKVPKLSNQRLRLGAMTTPFSIFRQRKLSETSIEENGLQIDTYGEGERLDGSVALMLESELDESTRIGGWIEMKQSNTRHLQWAVSMSDTPEDDLGWGLSMGGLVQGSRSWDHFQVEAFLNFSFGKRFRFQPAVVYLADRTSHFPAFLLRSSWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGP0</accession>
    <name>A0A068UGP0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00024721001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGP0"/>
    <dbReference type="FunCoup" id="A0A068UGP0">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGP0"/>
    <dbReference type="Gramene" id="CDP07452">
        <property type="protein sequence ID" value="CDP07452"/>
        <property type="gene ID" value="GSCOC_T00024721001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGP0"/>
    <dbReference type="OMA" id="IAINAEW"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGP0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010269">
        <property type="term" value="P:response to selenium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000057">
        <property type="entry name" value="Cysteine protease RD19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018569173" evidence="9">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="147"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="376" mass="41583" checksum="8DEC9E2E818793E9" modified="2014-10-01" version="1">MDRLFLFSLLLSFTLLSSAAASTAGDREAASIIQDDPLIRQVVTSDGDDADPLLNADHHFSLFKTKYGKTYSTQEEHDHRFSVFKANLRRAKRHQLLDPSAVHGVTKFSDLTPSEFRRNHLGLNKHKRRLRLPADANKAPILPTTDLPADFDWRDHGAVTPVKDQGSCGSCWSFSTTGALEGAHYLATRELVSLSEQQLVDCDHECDPAEYNSCDSGCNGGLMNNAFEYILKSGGVEREQDYPYTGRDEKCKFDKSKIAAKVSNFSVVSTDEDQIAANLVKHGPLAVAINAIWMQTYIGGVSCPYICSKSQDHGVLLVGYGAAGYAPIRLKDKPYWIIKNSWGENWGENGYYKFCRADRNLCGVDSMVSSVAAVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH43</accession>
    <name>A0A068UH43_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00024814001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH43"/>
    <dbReference type="STRING" id="49390.A0A068UH43"/>
    <dbReference type="Gramene" id="CDP07529">
        <property type="protein sequence ID" value="CDP07529"/>
        <property type="gene ID" value="GSCOC_T00024814001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH43"/>
    <dbReference type="OMA" id="ISPSKWA"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH43"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF10">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP07529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="139" mass="15277" checksum="1F251F308AC6571F" modified="2014-10-01" version="1">MVDQIGLSEALKNYMPFLYVRRLSDRATLPKRMFPHSAGYDLFSATDTKVPARGKARISTDLSIDIPPGAYGRIAARSSLAWDHSIEVGGGVVDADKNPVFVILYNHSDVDFVVKVGDRIAQLVIELNATPEVVEVHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH65</accession>
    <name>A0A068UH65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Splicing factor U2af small subunit B-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00024058001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Probably active at the 3' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH65"/>
    <dbReference type="STRING" id="49390.A0A068UH65"/>
    <dbReference type="Gramene" id="CDP06988">
        <property type="protein sequence ID" value="CDP06988"/>
        <property type="gene ID" value="GSCOC_T00024058001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH65"/>
    <dbReference type="OMA" id="XAVSDVE"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH65"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12539">
        <property type="entry name" value="RRM_U2AF35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="189"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP06988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="35652" checksum="159052D326AE870B" modified="2014-10-01" version="1">MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHTKPSISPTLLLSNMYQRPDMITPGVDAQGQPIDPHKMQEHFEDFYEDLFEELSKYGVIESLNICDNLADHMVGNVYVQFREEEQAANALKNLTGRYYAGRPIIVDFSPVTDFREATCRQYEENTCNRGGYCNFMHLKRISRELRRQLFGRYRRRRSRSRSPYRHRSHEERSHRHSRRYEDRDYHHESRSRRHRSTSPDRRRGRSRSRSPGGRRDRSPVRDGSEERRARIEMTMGMHKMEISIIDRSHHMDIELTVVVCRFTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHE4</accession>
    <name>A0A068UHE4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Premnaspirodiene oxygenase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00025373001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHE4"/>
    <dbReference type="STRING" id="49390.A0A068UHE4"/>
    <dbReference type="Gramene" id="CDP07886">
        <property type="protein sequence ID" value="CDP07886"/>
        <property type="gene ID" value="GSCOC_T00025373001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHE4"/>
    <dbReference type="OMA" id="MNTVWIA"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHE4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000043">
        <property type="entry name" value="Cytochrome P450 99A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052306">
        <property type="entry name" value="CYP450_71D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953:SF16">
        <property type="entry name" value="CYTOCHROME P450 71D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953">
        <property type="entry name" value="OS08G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657683" description="Premnaspirodiene oxygenase-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP07886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54707" checksum="38DBFFFE91E63C56" modified="2014-10-01" version="1">MELSFNFIALFLLVAFISTLIKQRNGSKAAQKLPPSPWKLPLIGNLHHLIGSPPHHALRNLSKKHGPLMHFQLGEVSSIVVSSSRLAKEVLKTHDLEFGNRAEFLATKILCYDYGDIASAPYGDYWRQMRKIYEALKLMSSIKTLAGAGKIVNLKEKLASYTSSMVCRAAFGKVSKDDHKAFLQLVMEALPLSSAFEISDLFPSLKILHPLFSAKTKLMKVHHKMDVILDKIIDQHIDNLARTRMAMGESGHEDLTDVLLRVKESGDLQFPITKNNVKAVLFDMFLGGTETSSTTLEWAMSELIKNPNVMTKVQNEVRKAFTGKKTIEENEIQQLQYLKLVIKETLRLHPPAPLSVPKQCREQCEIDGYSIPVKTRLFVNTWAIARDPEYWDDPESFKPERFENSSIDFTGNHFELLPFGSGRRICPGISFGIANVELPLTLLLYHFDWRLPNGLSPDDLDMIESVGIATTRKNDLCLLATLYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIC6</accession>
    <name>A0A068UIC6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024638001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="gene ID" value="GSCOC_T00024638001"/>
    </dbReference>
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    <dbReference type="OMA" id="HEFIKVH"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diphthamide-biosynth_chaperone"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240:SF22">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ 11, CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="156" mass="17200" checksum="BA926E46BBCFD8E0" modified="2014-10-01" version="1">MASSIGSTFAGAAPSCARFKHHLHQPSRISAAHAAAGRTSTSTSHIAPQTSLYEVLGIPMGATCQEIKVAYRRLARVLHPDVASSHNTTRGSQDTSAAADEFMRVHKAYTTLSDPEKRADYDRTLFRLRRPAYVLSATNRGSGYYARRTWETDQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKR1</accession>
    <name>A0A068UKR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRONE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00027919001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP08814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="CDP08814">
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        <property type="gene ID" value="GSCOC_T00027919001"/>
    </dbReference>
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    <dbReference type="OMA" id="ICDHIVE"/>
    <dbReference type="OrthoDB" id="1053009at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Rop guanine nucleotide exchange factor 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000003">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRONE domain, subdomain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PRONE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038937">
        <property type="entry name" value="RopGEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101:SF47">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRONE"/>
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    </dbReference>
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        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRONE" evidence="4">
        <location>
            <begin position="98"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP08814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="476" mass="53430" checksum="109BD29A606B8C58" modified="2014-10-01" version="1">MDSVGNSDETCDLGYQPSQSSLDQNDQSSSTEATSFSLQSGYSFCRTNSDVSAFSEPTDDNSSTFSETPSPLCWPGMKSPKTPVLSKLVMQQQNPAADDETENEDLELDMMKERFSKLLLGQDMSGSGKGVSTAVAVSNSITNLYASIFGQHLRLEPLHPDKKLMWKREMNCFLSICDHIVEFVPALHDLQDGTAVEVMTSRPRSDISVNLPALRKLDALLLEVLDSFEETEFWYAEQGSMSGKSRSGSFRRIPAPQRKEEKWWLPVPCVPSGGLSEKSRKHLRHKRDCANQIHKAAKALNNSILAEMEIPDSYMASLPKSGRAIVGDAVYRYMCNGEKFTPDLLLNCLNLGSEHEALEFADKIEASMYTWRRKACSMTHSKSSWDLVKDFMSDIDRTDKNHILAERAESLLFCLKQRYPELSQTSLDASKIQHNRDVGKAILESYSRVLEGLAFNVVAWIEDVLFVDKTTRNQDQ</sequence>
</entry>
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    <accession>A0A068ULD8</accession>
    <name>A0A068ULD8_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00028311001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP09112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULD8"/>
    <dbReference type="Gramene" id="CDP09112">
        <property type="protein sequence ID" value="CDP09112"/>
        <property type="gene ID" value="GSCOC_T00028311001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULD8"/>
    <dbReference type="OMA" id="YAEAQMW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000341">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000462">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001104">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF482">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="5">
        <location>
            <begin position="564"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP09112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="656" mass="73975" checksum="67DA4C2ADF8DB92F" modified="2014-10-01" version="1">MWTLYTSHTLQPHYFPLNFRPASRSHHQATVALRLPTATSTTPSTINHNPSIQSLCVKGQLKQALELLSQEPCPTQHTYELLILSCANQHSLSDALIVHRKLIDNGFDQDPFLATKLINMYHELDCIERVRQVFDKTLKKTIYVWNALFRALTLWGRGEEVLGLYSRMNRIGIPSDRFTYTYVLKACVAAETLGSLLQKGKEIHAHILRHGYESHIHIMTTMVDMYARFGCVADATSVFNSMPVKNVVSWSAMIACYAKNGKPFDALELFHQLVLDNCDTLPNSVTMVSVLQACAAVAALGQGKLIHGYILRKGLDSILPVISAMVTMYARCGNLEWGKRVFSQMEKKDVVAWNSMISSYGIHGFGREAIEVFKEMILSGVSPSPISFVSVLGACSHSGLIEEGRFLFESMIKEHGITPTVEHYACMVDLLGRANQLYEAAKIIQDMRIEPGAKVWGSLLGSCRIHCNIELAERASKRLFELEPRNAGNYVLLADIYAEAEMWSEVKRVKKLIEARGLQKVSGCCWIEVGRKVYSLTSVDEFNPQIEQIHALLIKLFIEMKEKGYVPKTKVVLYDLEADEKERIILGHSEKLAVAFGLINNSKGETIRITKNLRLCEDCHSFTKFISKFAGREILVRDVNRFHHFKDGVCSCADYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULJ2</accession>
    <name>A0A068ULJ2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027413001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULJ2"/>
    <dbReference type="STRING" id="49390.A0A068ULJ2"/>
    <dbReference type="Gramene" id="CDP08488">
        <property type="protein sequence ID" value="CDP08488"/>
        <property type="gene ID" value="GSCOC_T00027413001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULJ2"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULJ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="152" mass="17756" checksum="1D4FE1568024981D" modified="2014-10-01" version="1">MEVLGVLLGPRIGIQMDRVKGLDVDSLFISHIQVNQAHKQRRRTYRAHGRINPYMSSPCHIELILSEKEESVKKERLKTRVVRKNVNPEWNEDLTLSIADPSIPIKLQVFDKDTFSLDDKMGDDKRIRHSFSIYLNLLHTRVQNFASWLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNL1</accession>
    <name>A0A068UNL1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Legume lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030308001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNL1"/>
    <dbReference type="FunCoup" id="A0A068UNL1">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNL1"/>
    <dbReference type="Gramene" id="CDP09834">
        <property type="protein sequence ID" value="CDP09834"/>
        <property type="gene ID" value="GSCOC_T00030308001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNL1"/>
    <dbReference type="OMA" id="NTCHASD"/>
    <dbReference type="OrthoDB" id="1101105at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNL1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010605">
        <property type="entry name" value="DUF1191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF1191)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF1191)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06697">
        <property type="entry name" value="DUF1191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655052" description="Legume lectin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33695" checksum="F07397AACC6C4400" modified="2014-10-01" version="1">MGSFHTVTFIVFLSLASSTGLQIEAQGIKSARLLDLVIRDYTFQSYDRFFGTGKLHAVSLPANLSGIKVDTVRFRCGSLRRYGAKVSEFHLGTGVTVNPCVERVLIVAQNLGSNWSSIYYDNYELSGYQLISPVLGLLAYNAGDNINFSSPFELGIQAGKDPIKIDFRNTTKLNATTGIIPLCARFERDGKVTLANQASPNVCVSTRQGHFGLVIESPLMPMKKQVSKWKIAVGSSIGAALGAFLLTLLLIAIFVKVKKKARMEELERRAYEEEALQVSMVGHVRAPTASVTRTVPIIEHEYTPPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPM6</accession>
    <name>A0A068UPM6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00030900001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPM6"/>
    <dbReference type="FunCoup" id="A0A068UPM6">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPM6"/>
    <dbReference type="Gramene" id="CDP10237">
        <property type="protein sequence ID" value="CDP10237"/>
        <property type="gene ID" value="GSCOC_T00030900001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPM6"/>
    <dbReference type="OMA" id="QNQDLHM"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000127">
        <property type="entry name" value="DNase I superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19068" checksum="4B44DA26A93821B5" modified="2014-10-01" version="1">MDEFSPRARRRSALLTWQHIASLPPSLPVVYSGGFNTQKESTTGRFLLGRSREHGVVGDMRDTWPNARVRKNVSLIRTYHGFKGDKQGAVEFLKLIFRALCLCWDRQTQDLHVDWILFRGRSLIPVSCEVVSDNIDGLYPSSHYPIHAEFMLPRTVRLTDAPTQDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQ01</accession>
    <name>A0A068UQ01_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00030080001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQ01"/>
    <dbReference type="STRING" id="49390.A0A068UQ01"/>
    <dbReference type="Gramene" id="CDP09668">
        <property type="protein sequence ID" value="CDP09668"/>
        <property type="gene ID" value="GSCOC_T00030080001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQ01"/>
    <dbReference type="OMA" id="VSHAESH"/>
    <dbReference type="OrthoDB" id="1860322at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQ01"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="79" mass="8838" checksum="34695D148742DA2D" modified="2014-10-01" version="1">MLNIGVQVSECDSFCFIPIFSVASICYAHLAASQLGQWMKFEDTPEISSSHGEVSHAESHLVPELPRRKENVCNSMFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR98</accession>
    <name>A0A068UR98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00030744001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR98"/>
    <dbReference type="FunCoup" id="A0A068UR98">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP10128">
        <property type="protein sequence ID" value="CDP10128"/>
        <property type="gene ID" value="GSCOC_T00030744001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR98"/>
    <dbReference type="OMA" id="DCRHKYH"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37888">
        <property type="entry name" value="DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37888:SF11">
        <property type="entry name" value="DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="345"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
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        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP10128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="81248" checksum="66DE43626C6B35B6" modified="2014-10-01" version="1">MAGPNGATGDYGNESEAPAERLDSDDAAHWGTWEDLLLVCAVNRYGTNSWESVALEIQKRSTSPFLSLSLTPRNCQMKYLDLTRRFLFKHDPRNTDNAYKDDDVEAAGHDGSIISTDESVPLLEELRKLRVAELRRELERYDLSIVTLQSKVKKMKEERERCSTVSEIREEKASVLRKSEEAEAPPERDASEDKVKVIMDELEKSPSSMANNKDEQSVNGSVPKDGRVGEIEAGRDEDKLVKEEDSGYGSSDSVEREYRKPGPESVPNEVKVEPESVSHSPELVESVAESKDGGATKSRRDGENDDVPPGSTKNLDLQNDNSSPPVKLEASVESQPLIDFLDHVKGHKLGSLFLRRLDSQEAPNYKSLIRQHVDLEAVRRRVKEGIYSDSNLKFFRDLLLLVNNAMVFFGKNTPEFLAAMELRHLIANEMARRNAKSSDSSSEKQASLQKASLPDKGSSEPSESLLRKPKLGGQLIVCRKRSSIAAKASASSSASDKKRDQNKMPTEDSAGLDSKHPSRRQQPARAEGPRVTKKRSADRFASASTSLKKNAKNGAGTNSKQMSGTNLEKNKGKGGSSSQQPDPRCENKNNQSSADLKKRSAANFLNRMKQSSSSNNSTLLDALKGSPLSASNNGRGGSELKKDENSKGSGGSNLRKNEHGKGGGGSEHKKNENVKWSGKKAQVSTRSSDVKQATEKTIPATKSLGRPLNKGAAPPAPSGKRGRGDRESESAASKQQRKKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US28</accession>
    <name>A0A068US28_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00033066001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068US28"/>
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        <property type="gene ID" value="GSCOC_T00033066001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US28"/>
    <dbReference type="OMA" id="ATASALX"/>
    <dbReference type="OrthoDB" id="1849581at2759"/>
    <dbReference type="PhylomeDB" id="A0A068US28"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S15p_S13e"/>
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        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S15/NS1, RNA-binding"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
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        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF25">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15Y-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="17155" checksum="E053C4791F1AC926" modified="2014-10-01" version="1">MGRMHSRGKGISASALPYKRTPPSWLKISSQDVDDNICKFAKRGMTPSQIGVILRDSHGIAQVKSVTGSKILRILKAHGLAPEIPEDLYHLIKKAVAIRKHLERNRKDKDSKFRLILVESRIHRLARYYKKTKKLPPNWKYESTTASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USG1</accession>
    <name>A0A068USG1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033761001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USG1"/>
    <dbReference type="FunCoup" id="A0A068USG1">
        <property type="interactions" value="1504"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP11485">
        <property type="protein sequence ID" value="CDP11485"/>
        <property type="gene ID" value="GSCOC_T00033761001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USG1"/>
    <dbReference type="OMA" id="KETSEWC"/>
    <dbReference type="OrthoDB" id="2014733at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33874">
        <property type="entry name" value="RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33874:SF1">
        <property type="entry name" value="RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="253" mass="28122" checksum="04E4DD0D1051A3AC" modified="2014-10-01" version="1">MEVEQVVTAAGEKAILQLERMNSDRDRVRVKRKTLEAVLGECQRALQLLSTAGCIDEEDDDDVDHDEPASHHYEIDDDGPAGGSSSPSPSRDKETSEWCDLIKSRVECTDFLEKLENAQASVPQNIAEEGTSWDMVNENDLWEGGNSELDQEDYVLVRQEDIVDGIACFMAAYLLSLKQTKELTPNQLQDALCKTFSVKKKKGKLRKAWDGSKVIYNVASWGATAIGIYQNPAILKAASAAFWTSCRVISKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTS5</accession>
    <name>A0A068UTS5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00034040001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739141">
        <property type="protein sequence ID" value="CDP11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTS5"/>
    <dbReference type="STRING" id="49390.A0A068UTS5"/>
    <dbReference type="Gramene" id="CDP11644">
        <property type="protein sequence ID" value="CDP11644"/>
        <property type="gene ID" value="GSCOC_T00034040001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTS5"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTS5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655196" description="Vacuolar protein sorting-associated protein 51 homolog" evidence="4">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="189" mass="21815" checksum="F8BD2678B93C4E87" modified="2014-10-01" version="1">MVLPGIVLLLAQLSLFIEQSVIPRITEVTFCSEIASSFSSGGARGYEYGPAFIPAVICRTFWVAGEKCLDHYVRLRTQKISVLLRTRFTTPNWVKEPREVHMFVDLLLQEFEAIRGKVKQILPPELSRKHCRRDSNGSTTSSRSNPLRDDRMNRSNTQRATSQLLESHLAKLFKQKMEIFRKIEFTQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UW69</accession>
    <name>A0A068UW69_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00036358001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UW69"/>
    <dbReference type="STRING" id="49390.A0A068UW69"/>
    <dbReference type="Gramene" id="CDP12651">
        <property type="protein sequence ID" value="CDP12651"/>
        <property type="gene ID" value="GSCOC_T00036358001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UW69"/>
    <dbReference type="OMA" id="GRKSAFY"/>
    <dbReference type="OrthoDB" id="772609at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UW69"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31587:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31587">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN (DUF2215)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="515" mass="57073" checksum="16DF2179BD0E8AE9" modified="2014-10-01" version="1">MGLSSASSTLLPMAVFSLSLLFSLFALAPQVIALKGIDVENPAVDVAPRLPVVSGLSKDAALCERVQVAGISRLKIGKYSSAYRVTVAPSVVIPERLHNKIQICFHKNSSLGLCQCEKDDWKSVTKGILVSVASPYEDRYIDVKFVGDLSGSVTVTVEEEFQGWRLIFLALGIMLLLLAPIVSSWVPFYYSSSMAIGICLVIIILLFQGMKLLPTGRKSIFYLTIYGSVLGAGSFLLRHFSMLVNSILINFGLSEEMYNPVSVFLLVGITLAGAGLGYWLVRKFVVAEDGSVNVGIAQFVKWAIRIVAVTFIFQSTLDILLAVAVLISCLAMCFGFTSMRWNDLEDLPFSLDGSLWAWRSGQANVKHKHAEFYSRPGKKNHHSTLWNSPKGSFPGSPAKGLQSPFQRVTRTQQGYYSPSARRGTRNWQDHYSTFHETPNRKKYTKQEWEDFTQESTRQGLAELASSPEFTDWIIKNADRIQLRSDHSSDETVGSGSDSTDEQAVESSNGIRLFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWB6</accession>
    <name>A0A068UWB6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00035231001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWB6"/>
    <dbReference type="STRING" id="49390.A0A068UWB6"/>
    <dbReference type="Gramene" id="CDP11923">
        <property type="protein sequence ID" value="CDP11923"/>
        <property type="gene ID" value="GSCOC_T00035231001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWB6"/>
    <dbReference type="PhylomeDB" id="A0A068UWB6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="66" mass="7487" checksum="5D228B9A5BFAC5AF" modified="2014-10-01" version="1">MVDENTSLIMWHNGHTICSACKVRAHNRYPTCIGDIRCFSLEKVTESLELPPKYCSLGCPEIFLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWW8</accession>
    <name>A0A068UWW8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00037424001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="18"/>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWW8"/>
    <dbReference type="STRING" id="49390.A0A068UWW8"/>
    <dbReference type="Gramene" id="CDP12777">
        <property type="protein sequence ID" value="CDP12777"/>
        <property type="gene ID" value="GSCOC_T00037424001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWW8"/>
    <dbReference type="OMA" id="DESEAYW"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWW8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000237">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF27">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655179" description="Receptor-like serine/threonine-protein kinase" evidence="21">
        <location>
            <begin position="24"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="496"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="778" mass="87852" checksum="444EC22406B6FD95" modified="2014-10-01" version="1">MASLTAVFWIFFLVTVTSETAVAQPDDLNMIPLGSSLFPVTQPTAWYSRSKRFAFGFFQTGEGYKVEIRIVGSGNGITVWTFNRDEPAVSSNATLDFVNGKLQLKHGNQYQTIADHPSKSALSACLLDSGNFVLYDENHALLWQSFEFPTDTILGGQILYSGKELISSLSQDDQSSGLFHLKMEYSGNLVAYRVDVTSETYWGPFNVSYSNNSQLILDNFTGTLSLIEPSDSSLVQVLTSAISRIRGNIYRATLGYDGNFRLYTHSFDAVTLQFKMRTEWEAIDDLCDIKGICGFNSYCTSKDMEWNCSCIPGFNFIRDLSSLSINIYGCEKNFTGGMCINGKEDAARNSMTPVSILGEDRPYFQEYQGNQDDCMKSCSEDCDCDAATYSDLHCSRYRLPLMYLRNATFTLSIAFIKSPNPQNDHLKKEVSWLTFFAMSLSFVTYSSVVLACFGIFMFKFHVLKYKKLLLQTRTTGLIKEFTLQTYTYNELKKATKGFRQELGKGAFGAVHRGSFDKGKSFVAVKRLEKVVEEGEREFRAEMRAIGRTRHRNLVQLLGYCIEGPKRLLVYELMVNGSLADLLFKGRLHPNWNDRVQIALDIARGILYLHEGCEAPIIHCDIKPQNILLDQFWTAKISDFGLAKLLMPDQTRTDTGARGTRGYMAPEWNKNIPISVKVDVYSFGIVLLEIICCRRNLQVNLAIPEATLLSGWAYQCFAAKELDKLVSWEEVDKTAFERVLKVALWCIQDEPALRFPMKIVLRMLEGLVDVPIPPCPSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXU5</accession>
    <name>A0A068UXU5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037852001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXU5"/>
    <dbReference type="Gramene" id="CDP13079">
        <property type="protein sequence ID" value="CDP13079"/>
        <property type="gene ID" value="GSCOC_T00037852001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="110" mass="12689" checksum="F6A0B93CE4E018EE" modified="2014-10-01" version="1">MRRLTKLTRVDVFDCPLLRQQYTPQRGIYYLEEEISSDPASSESEEEEIDDNELAGRKGEQKSIDSAETSASWCFPSLLKKRKSSGGMLCRKVIMQHFSPQELFSYLHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZB3</accession>
    <name>A0A068UZB3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039010001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZB3"/>
    <dbReference type="STRING" id="49390.A0A068UZB3"/>
    <dbReference type="Gramene" id="CDP13880">
        <property type="protein sequence ID" value="CDP13880"/>
        <property type="gene ID" value="GSCOC_T00039010001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZB3"/>
    <dbReference type="OMA" id="YRIAMTR"/>
    <dbReference type="OrthoDB" id="2016421at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZB3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36354">
        <property type="entry name" value="IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36354:SF2">
        <property type="entry name" value="IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23660" checksum="BDA8B7F24DD1712D" modified="2014-10-01" version="1">MFGIANTFVGLSEGMAKYGFLALSTAIVSFAILYLRSRFTVNPDKVYRMAMRRLNTSAGILEVMGAPLTGTDLRAYVMSGGGITLKTFKPRFRNKRCFLIFPIRGSERKGLVSVEVKNKNGQYDMKLLAVDIPMATGPDQRLFLIGDEEEYRVGGGLISELRDPVVKAMAASKEFEDRDDQEDEEDAERELQEAERKQREEIEKLEKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZB7</accession>
    <name>A0A068UZB7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00038783001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZB7"/>
    <dbReference type="STRING" id="49390.A0A068UZB7"/>
    <dbReference type="Gramene" id="CDP13736">
        <property type="protein sequence ID" value="CDP13736"/>
        <property type="gene ID" value="GSCOC_T00038783001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZB7"/>
    <dbReference type="OMA" id="GAMDHRE"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZB7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000002">
        <property type="entry name" value="Magnesium/cobalt efflux protein CorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777">
        <property type="entry name" value="HEMOLYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777:SF17">
        <property type="entry name" value="UPF0053 PROTEIN SLL0260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="89"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="37871" checksum="7A347446DDD64CAA" modified="2014-10-01" version="1">MLNFDMIENVLEIKDTHVREVMTPLVDVVAIDASATLVDFHDLWVTHQYSRVPVFEQRIDNIVGIAYAMDLLDFVQKGDLLESSVVGDMAHKPAYFVPDSMSVWNLLREFRIRKVHMAVVLNEYGGTIGLVTLEDVVEEIVGEIFDENDSSEEIQKKTGYIVMRAQGIYDVDANTSIDHLSEDLNIKMPEGHQYETVSGFVCEAFGYIPRTGETIKVVLERENEEENDEYEEAESDRTDQHEKSQIFKLEILAGNARKVSAVRFERVNQDDELETKEVTRLVPKIMKKKWGADDDTDKADDGVLVKEIVDHNLSDDTVNAEHVDSHDHQIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZU3</accession>
    <name>A0A068UZU3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00038797001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZU3"/>
    <dbReference type="STRING" id="49390.A0A068UZU3"/>
    <dbReference type="Gramene" id="CDP13749">
        <property type="protein sequence ID" value="CDP13749"/>
        <property type="gene ID" value="GSCOC_T00038797001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZU3"/>
    <dbReference type="OMA" id="KDFPWKL"/>
    <dbReference type="OrthoDB" id="5966500at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZU3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF77">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655418" description="Protein kinase domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="278"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="558" mass="63148" checksum="7A1CD08553FF64FF" modified="2014-10-01" version="1">MQRGSIPWLAALAGLALFVSGCNGGELSEIELFFNFIRALDPKTVLRIEWSRSLRQPCSNQWNVVVRCKMVSLFGRPVTEIRLQNLNLSGILDAETLCKLPILCVLIFAKNRIRGTVPDSIADCKSLMHLDLSNSLLTGSLPAVALSKLKNLKRFDISDNHYGSTDPQLNREARPPEDVSHGKQSSKNDDNPRKHWQSWMVVLAMGVTFVLLLIFFTKLKAVQAAKDTEITRELALSLSPPKSPHVEIVVEEKAEERHSELVFFIEKHERFGLEELLEASADLRWQGHCSSLYGVRLKNNATFAVKRLKKLQVSFEEFGQTMRKIGNLKHQNILSLVGYNSSKEKKLLIYRFQNNGSLLTLFNDYIEGKRNLPWKLRLSIAIGIARGLNFIYQWPEDGEIIPHGNIKPSNIMLDEKEEPLISEYGIAKFLVSNKARFFNSSSYAAPEKRLTEQADVYSFGVILLELLTGKFAEMQKNGLDLPKWVKAKVREEWTGEVFDKEIEKFEMYGFSLLNISLKCVSELPGDRPSISEVLEKIQEVVTAQEDISSSSTNSVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0N6</accession>
    <name>A0A068V0N6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00040684001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0N6"/>
    <dbReference type="FunCoup" id="A0A068V0N6">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0N6"/>
    <dbReference type="Gramene" id="CDP14350">
        <property type="protein sequence ID" value="CDP14350"/>
        <property type="gene ID" value="GSCOC_T00040684001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0N6"/>
    <dbReference type="OMA" id="TWKPNNN"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0N6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat I (LRI)" evidence="3">
        <location>
            <begin position="381"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="460"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="679"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="491"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP14350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="756" mass="85018" checksum="024FFB5C528118A8" modified="2014-10-01" version="1">MDPSFLGIPASARGIRLRNQNLSTFGDLNPNGPTFETLYLDQKRVNHGLTTKNAPLQYNFDGGVEFLPSDPSPSNLTSTSSLGVEDDFSEDLDFSDAVLRYINQMLMEEDMEDKAYMLQESLDLQAKEKSFYEALGKKYPPSPEPHPTFIFQNGTSPDECFSGDQCNLTSTSSNPGSYIAEPSSLNNLAHYDATSLVHCHHAHRAPSSSLSSSTVNSFLDSPSSPPYGSHSVWNFKKGVEEASKFLPDGNKLLNFSINGLFPLELAEEIEEPILKEEGRDEVNFLPTGSRGRKNPHGGDTDLEERSSKLAAVFTESTVRSEEFDIVLLHSMGEGQVALAAYQENLRTAKSKVMLQNGQPKLKGSSGGKGRRKKQNVKKQVIDLRTLMIHCAQAVAADDHRSANELLKQIRQHASPFGDGNQRLAHCFAQGLEARIAGTGSQIYKALVNKRTSAADFLKAFHLYLASCPFRKISNFASNKTIMIESKNAVRVHVIDFGILYGFQWPTFFQRIAGREGGPPKVRITGIEFPQPGFRPAERIQETGHRLAEYAKMFKVPFEYNAVAKKWETIKLEDLKIEEGEFVVVNCIYRSKNLFDETVAVESSRTIVLKLIRSINPDIFIHGIVNGAYSAPFFVTRFREALFHFSALFDMLETIVPREIPERTLIEKEIFGREALNVIACEGWERVERPETYKQWQVRNLRAGFRQIPLDREIMKKAIEKVTSGYHKDFVIDEDSQWLLLGWKGRIIYSLSCWTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V214</accession>
    <name>A0A068V214_COFCA</name>
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        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041149001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="GSCOC_T00041149001"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="95" mass="10459" checksum="F8EF91B1C7CF92CE" modified="2014-10-01" version="1">MITSLPSWPTEAPPTLPANPSFHHCSTPPPSTLYHPQISSTIPQPCTLPLQSASEKLIQFNTQTPYTLNRAPFPFSAPLHLRPQPQAAPQSTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2Y7</accession>
    <name>A0A068V2Y7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cold and drought-regulated protein CORA-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042747001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739179">
        <property type="protein sequence ID" value="CDP15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2Y7"/>
    <dbReference type="STRING" id="49390.A0A068V2Y7"/>
    <dbReference type="Gramene" id="CDP15150">
        <property type="protein sequence ID" value="CDP15150"/>
        <property type="gene ID" value="GSCOC_T00042747001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2Y7"/>
    <dbReference type="OMA" id="KCCTYEE"/>
    <dbReference type="OrthoDB" id="1936545at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010800">
        <property type="entry name" value="GRP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07172">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="15761" checksum="2D014475A0C3E684" modified="2014-10-01" version="1" fragment="single">SICTTFLILLKISLQYINFPSAKMGSKTLLFFFISMAVVLMITSEVAAKSVDNSKTVETNEEGEAKYHGGGYGGGHGGGYGGGHGGHGGGYGGGHGGGHGGHHGGGYGGHPGEGNGDGHGGYGGGGHGGYGHGGGSHGGYGHGGHGGGGHGGHPGEAADAKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V374</accession>
    <name>A0A068V374_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00042828001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V374"/>
    <dbReference type="FunCoup" id="A0A068V374">
        <property type="interactions" value="2278"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V374"/>
    <dbReference type="Gramene" id="CDP15205">
        <property type="protein sequence ID" value="CDP15205"/>
        <property type="gene ID" value="GSCOC_T00042828001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V374"/>
    <dbReference type="OMA" id="WMGPSNA"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V374"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="233"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="762" mass="84614" checksum="045AC157CD9E6CFA" modified="2014-10-01" version="1">MAKDHVIAIKDAVHRLQLSLLEGIQDENKLFAAGSVMSQSDYQDVVTERSITNLCGYPLCGNSLPLERPRKGRYRISLKEHKVYDLHETYMYCSTNCVVNSQAFVASLQEERSSTLNPVKLNEILRLFEGLSLEESSGGFGKNSDLELSKLRIQEMTDTGSGEVSLDEWIGPSNAIEGYVPLKDSCSNIQQARNLEKGCKSEHAYIQQIKDNFFNDMDFTSTLIIQDEYSISKSPDPARSISGHKTDKQKGKMKHKDMKDDESSELEGRVVSEGNKIEKKNLDKAPRKPAIKDNLGDSLGDLSNDIDEKLIKDNFFNDMDFTSTLIIQDEYSISKSPDPARSISGHKTDKQKGKMKHKDMKDDESSELEGRVVSEGNKIEKKNLDKAPRKPAIKDNLGDSLGDLSNDIDEKLVISDSFSEFQAEKASSSTANMLKPSLKSSKGKRGTRSVTWADEKVDGDGSKSLCEFRELEDTKNIFSQPGSAVMEVNEDPYRFASAEVCARALSEAAEAVVSGDADTSDAVAEAGIIVLPPHPEVHGTEAQVEVDMPDSETNVLKWPMKSGLSNSDLLDPNDSWYDTPPEGFSLNLSPFATMFMALFGWISSSSLAYIYGHDESLHEDYLYINGREYPCKIFSTDGRSLEIKQALAGCLARALPALVADLQLPMPLSTLEKEMDHLLDTMSFMDPLPPFRMKQWQLLVLLLLDALSVCRIPALTPYMTGRRILLPKVLQGAQISAEEYEIMKDLIIPLGRVPQFAMQCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V427</accession>
    <name>A0A068V427_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041208001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739173">
        <property type="protein sequence ID" value="CDP14618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V427"/>
    <dbReference type="FunCoup" id="A0A068V427">
        <property type="interactions" value="798"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V427"/>
    <dbReference type="Gramene" id="CDP14618">
        <property type="protein sequence ID" value="CDP14618"/>
        <property type="gene ID" value="GSCOC_T00041208001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V427"/>
    <dbReference type="OMA" id="SSPVMEH"/>
    <dbReference type="OrthoDB" id="784654at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V427"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012862">
        <property type="entry name" value="DUF1635"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431">
        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431:SF3">
        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07795">
        <property type="entry name" value="DUF1635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="280" mass="31462" checksum="F3374ACC11140C98" modified="2014-10-01" version="1">MESQRGPLLNWPYFYQGKGMDELRQSLLLTTMELENTRLKAQEELKMRDDQLFQLKDLLSRTIKERDEAQKPCQRLVLDKLLLQQQQLMLQRQNQQSAPLSGISSIEDEPRRGGGGMDSNNGFSSSDCEESIVSSPIIEQNPPQELTHQLQVQPQHPTAELDPTLPILTDRPLPEKGQFLQAVMKAGPLLQTLLLAGPLPQWCHPPPPLDSYQIPPPPVVVPPPPTPLTLSGHSLNQDSLLTIAAYNSNINNCGRMNRKRGYFEGSDSSTEAKYQRLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4Q3</accession>
    <name>A0A068V4Q3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00015748001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739189">
        <property type="protein sequence ID" value="CDP15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4Q3"/>
    <dbReference type="FunCoup" id="A0A068V4Q3">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4Q3"/>
    <dbReference type="Gramene" id="CDP15725">
        <property type="protein sequence ID" value="CDP15725"/>
        <property type="gene ID" value="GSCOC_T00015748001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4Q3"/>
    <dbReference type="OMA" id="HIQISAI"/>
    <dbReference type="OrthoDB" id="1906227at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4Q3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051983">
        <property type="term" value="P:regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.570">
        <property type="entry name" value="Ncd80 complex, Spc24 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044951">
        <property type="entry name" value="SPC24-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35730">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35730:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="17688" checksum="2ADDE48310132F1D" modified="2014-10-01" version="1">MADSTRFEVEKLIAYGHELVDFLRDDGDNITLKQYFQQAQSLHSRAHADFNGLQRSIQVIIDEINDLEQQSESIEERRKSLKKLEQEDLRREMKLSMYASVTSIVPNLDDQSKISGHIVEREEKRVEKFELDPVKQTTFETCNGIWKMINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V577</accession>
    <name>A0A068V577_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00016654001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739194">
        <property type="protein sequence ID" value="CDP15806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V577"/>
    <dbReference type="FunCoup" id="A0A068V577">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V577"/>
    <dbReference type="Gramene" id="CDP15806">
        <property type="protein sequence ID" value="CDP15806"/>
        <property type="gene ID" value="GSCOC_T00016654001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V577"/>
    <dbReference type="OMA" id="AKHGLGC"/>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V577"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF176">
        <property type="entry name" value="HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7_9 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="435" mass="48664" checksum="1D173748013FECF2" modified="2014-10-01" version="1">MDGQKSQAKLSRTNSSLLRSSPTIRSSIHSLSSVSEITPDHEEEAAGYHYQDLEEQKPHSKPGSTTSSSRVVSGSARLAPVLVLCLISMYTLFVFFNRDEIASSENLLLALIFVAVLLFFAQRNKGLIHQSISVLKHLFDEYGKKIGWSSKNQSKSVQWFIGEQPDMGTKEVQKEKNLKKCIKEGVEFYSNGDFYEGEFHKGRCNGSGVYNYFGNGRYEGDWVDGRYDGYGIESWARGSRYRGQYRNGLRHGYGVYRFYTGDSYSGEWFNGQSHGVGLQTCSDGSCYIGEFKAGVKHGLGVYHFRNGDRYAGEYFGDKIHGFGVYHFANGHCYEGSWHEGRKQGFGMYTFRNGDTKCGEWDLGNLKNPSPPLDEAVLRAVQAARRTAEKAIHFRGVDEQVNKAVMAANRAATAARVAAVKALQNRIDGKFCDTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5E3</accession>
    <name>A0A068V5E3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00015722001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739188">
        <property type="protein sequence ID" value="CDP15714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5E3"/>
    <dbReference type="Gramene" id="CDP15714">
        <property type="protein sequence ID" value="CDP15714"/>
        <property type="gene ID" value="GSCOC_T00015722001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5E3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP15714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="81" mass="9517" checksum="01017C7B396AF440" modified="2014-10-01" version="1">MSLFFRFYLSKSKIRITLKTCESVVHLWRISSFFFPSPSPCLPPSPSLPCKYIIYFLPFCLYIFLSWCQEISFSISSGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5X6</accession>
    <name>A0A068V5X6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017075001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP16066"/>
        <property type="gene ID" value="GSCOC_T00017075001"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="54" mass="6501" checksum="0C2C939F30ECA06E" modified="2014-10-01" version="1">MLKFLFFWSRSLPNDEVCIFFLLDIVFKVFILSFTQYNFQDCICICLKVGNWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V606</accession>
    <name>A0A068V606_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017110001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739199">
        <property type="protein sequence ID" value="CDP16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V606"/>
    <dbReference type="Gramene" id="CDP16091">
        <property type="protein sequence ID" value="CDP16091"/>
        <property type="gene ID" value="GSCOC_T00017110001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V606"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="53" mass="6082" checksum="2386B832D1D6376D" modified="2014-10-01" version="1">MSSEVSPEKWIALSNQHHGIFVLLGEKNKIVLFRKIATKRGCRWFSGSHTCPR</sequence>
</entry>
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    <accession>A0A068V8X7</accession>
    <name>A0A068V8X7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00004915001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8X7"/>
    <dbReference type="FunCoup" id="A0A068V8X7">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8X7"/>
    <dbReference type="Gramene" id="CDP17017">
        <property type="protein sequence ID" value="CDP17017"/>
        <property type="gene ID" value="GSCOC_T00004915001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8X7"/>
    <dbReference type="OMA" id="EYVYRIS"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8X7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16764" checksum="A3C1CC3163708E88" modified="2014-10-01" version="1">MAEIEKEKGWNSCKNTKKGGGGGGGGEQGFCNDYVYRISTAEEWAELQTSGSTFGRQIDKSTGCIHLSNLHQVQWVLHNFFLNSKGQDLFLLQIHAKKLGDGLVYEAAADDSSKVFPHFYGPSRSFGPLPLDVVTKAEKIILSDAKFTCCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9E7</accession>
    <name>A0A068V9E7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013650001</name>
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    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Magnoliopsida</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Leroy T."/>
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                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9E7"/>
    <dbReference type="STRING" id="49390.A0A068V9E7"/>
    <dbReference type="Gramene" id="CDP17241">
        <property type="protein sequence ID" value="CDP17241"/>
        <property type="gene ID" value="GSCOC_T00013650001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9E7"/>
    <dbReference type="OrthoDB" id="1741166at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9E7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7097" checksum="B8A034F4996DAEA1" modified="2014-10-01" version="1">MLSRSYTNLLDLASGNIPVMGREKERRRFPRVMTVPGSICELDDDQAHSVSSDNPSSILFLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9I8</accession>
    <name>A0A068V9I8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00002992001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739243">
        <property type="protein sequence ID" value="CDP17435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9I8"/>
    <dbReference type="Gramene" id="CDP17435">
        <property type="protein sequence ID" value="CDP17435"/>
        <property type="gene ID" value="GSCOC_T00002992001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9I8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="60" mass="6998" checksum="44FBFBFC73D34280" modified="2014-10-01" version="1">MKEDLYHAPSVGCLDMLQFFSLSARRKRYRMMIGSKLRKVWRPKSQKGLDPGVIVIAEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAJ7</accession>
    <name>A0A068VAJ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00005135001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739253">
        <property type="protein sequence ID" value="CDP17622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAJ7"/>
    <dbReference type="FunCoup" id="A0A068VAJ7">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAJ7"/>
    <dbReference type="Gramene" id="CDP17622">
        <property type="protein sequence ID" value="CDP17622"/>
        <property type="gene ID" value="GSCOC_T00005135001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAJ7"/>
    <dbReference type="OMA" id="YLCSYYG"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAJ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000008">
        <property type="entry name" value="Protein argonaute 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="8">
        <location>
            <begin position="424"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="9">
        <location>
            <begin position="727"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP17622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118622" checksum="FD49EA309FF0C059" modified="2014-10-01" version="1">MEGKNYGRGGTGGGSSGRGRGGRGRGRGRGRSSGGDDQSYGGGRGRGRGTHMGGGYDSRFPGGGESDRSYRGQYDQRQGDSGGRGAWGRGAHEGGYARAVSGGGGEMDQRYRGQYPQLEGGRGARGPGTQVAGGVGGGEFIQKQPSAGGVGPGGRGAWTGRPWGPSASSSSSPAQYQPRPQHPQPTPALPDVQSLRISEEKPLSAEGKPDNKLLPIKRPDRGILAVRTVKLLANHFPVKFNSEGIITHYDVDIQQVMPGGNQPHRRSIPKALLSLIKDKLFSDEGFPVDMVTYDGEKNIFSAVALPTGEFNVELSDGEENVRTYKFVIQKVNQLKLSNLKDYLCGNLPHIPRDILQAMDLVMKHNPSMHRIPVGRSFYSKNERGDDLGHGIAAYRGFYQSLKPTSNGLALCLDYSVLAFRKPLPVIDFLKENVEGFRGVNDVTRMRRRVESALKGLKVRVTHRKTKQKYTISGLTRDITRLIKFPLVDPDGQVPPREVSLVDYFRQKYEEKIAHLDIPCLDLGRKDKRNDVPMEFCVLVEGQRYSKDYLERNEKDAAVLLKQISLAPPAVRKRTICDMVQAEDGPDGVVAKGFNMQLEKCMTSVGGRVLGAPELKLGGKNGNVYPVRVDQEKCQWNLVDKCVVQGKPVERWALIDFTSSSRYRLRKEDFIRNLIQRARRLGMHMEEPLVCHSTGMDEFYSVDRIGALLRKVIADARPRSGSQGTLQVIVCVMAGKDPGYKYLKWVSETRIGVMTQCCLCSQANRGQDQYLANLCLKINAKLGGSNVELNDRLPNFADEDYVMFIGADVNHPAARNSTCPSIAAVVGTINWPAANRYAARVQPQEHRKEKIVNFGSICRDLVSTYAKLNKIRPKRIVVFRDGVSEGQFDMVLNEELLDLKRAICDENYEPTITLVVAQKRHHTRLFLEGGRDNRGGNVPPGTVVDTTIVHPFEFDFYLCSHYGTLGTSKPTHYYVLWDENAFTSDRLQKLIYNMCFTYARCTKPVSLVPPVYYADLVAYRGRMFQEVAMEQPPASSPSSSSATPSVSLSSSASFDHNFYTLHPDLQNVMFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAQ0</accession>
    <name>A0A068VAQ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00003926001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068VAQ0">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAQ0"/>
    <dbReference type="Gramene" id="CDP17801">
        <property type="protein sequence ID" value="CDP17801"/>
        <property type="gene ID" value="GSCOC_T00003926001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAQ0"/>
    <dbReference type="OMA" id="NMPINES"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAQ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF157">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1723"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1848"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2291"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1658"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2330"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1666"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2338"/>
            <end position="2355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP17801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2592" mass="284019" checksum="911E016F58737F4A" modified="2014-10-01" version="1">MGGKESRGPACTFEFDGESSGLLGPGESRWPFINGYAFATWIYIESFADTLNTATAAAAIAAAAAATSGKSSAMSAAAAASALAGEGTAHMPRLFSFLSADNQGMEAYFHAQFLVVECGSGKGRKASLHFTHAFKPQCWYFIGLEHTCKQGLLGKAESELRLYIDGSLYENRPFDFPRISKPLAFCCIGTNPPPTMAGLQRRRRQCPLFAEMGPVYIFKEPIGPEKMIRLASRGGDVLPCFGNGAGLPWLAANDHVQKMAEENANLDAEIAGSLHLLYHPNLLNGRYCPDASPSAVAGMHRRPAEVLGQVHVANRMRATEAFWALSYGGPMSLLPLTVSNVHDNSLEPQQGDLSLSLATTSLAAPIFRIISLAIQYPGNVEELCRRRGPEVLSRVLNYLLQTLSSLDAARNDGVGNEELVAAVVSLCQSQKQNHALKVQLFSTLLLDLKIWSLCSYGLQKKLLSSLADMVFTESSIMRDANAIQMLLDGCRRCYWTTRESDSVDTFSIDDAARPVGEVNALVDELLVVIELLVLAAPPSVAVDDVRCLLGFMVDCPQLNQVSRVLHLIYRLVVQPNASRAQTFSEAFMAYGGIETLLVLLQREAKAGDLDEPELSTENEKSLSTGKSDLNNQDGLLESSHIGNTGHMEENELASPEKGKLESSTIERMSSVSEYLFLRNLGGITSSISAENARKNVYNADKSDSIVVGIINILGALVISGHLKFGTHAPPDMSNNLLGLLEGGGTMFDDKVSLLLFALQRAFQAAPNRLMTSRVYTALLGASLNAPSTDDGLNFYDSGHRFEHLQLLLVLLRSLPYASKTFQSRALQDLLILACSHPENRRSLTAMEEWPEWILEILISNYETSVVTTETSSSLKDVEDLIHNFLIIILEYSMRQKDGWQDIEATIHCAEWLSMVGGSSTGDQRIRREESLPMFKRRLLSDLLDFAARELQVQQTQVIAAASAGVAAEGLAPKLAKLEAENAAQVSVALVENAIVILMLVEDHLRLQSKIYTTSRFPAVSPSPLSTVLPVGHSSTIVGEPLETLAERKSSSGDSAGLPLDVLASMADANGQLSAAVMERLTAAAAAEPYESVACAFVSYGSCVMDLTEGWKYRSRLWYGVGQPSNASAFGGGGSGREAWKSALEKDANGNWIELPLIKKSVFMLQALLLDESGLGGGLGIGGGSGTGMGGMALLYQLLDSDQPFLCMLRMVLVSLREDDDGKDSMLVDVEDGSSEVSRRQTSNIASFDVNARMSSRKPRSSLLWSVLSPVLNMPVSESKRQRVLVAACILYSEVWHAVSRDRIPLRKQYLETILPPFVALLRRWRPLLAGIYELATADGLNPLVLEDRALAADALPIEAALAMISPSWAAAFASPPAAMGLAMIAAGAAGGETTVSATTSHLRRDSSLLERKTTRLHTFSSFQKPLEAPSKSPAAPKDKAAAKAAALAAARDLERNAKIGSGRGLSAVAMATSAQRRNKSDMGRVKRWNVSDAMGTAWMECLQSVDTKAVYGKDFNALSYKFIAVLVGSLALARNMQRLEVDRRMQVEVISRHRLCTGIREWRKLIHYLIEMECLFGPFGNRLCNPQRIFWKLDFTESSSRMRRYLRRNYHGSDHFGAAANYEEPSELKQDKDSVVTPSKASMLAAEAISIEVLNADDDQEDSANPGGQSTDTNLNGDIQSRITETADQPLRTSMESRDAPVTNNQDLAQNPAVVAPGYVPSEHDERIVLELPSSMVRPLKILRGTFQITTRRINFIVDSSESNTSGDGLDCRNETKIEEKDRSWLISSLHQIYSRRYLLRRSALEIFMVDRSNFFFDFGSTDGRRNAYRAIVQARPPHLNNIYLATQRPEQLLQRTQLMERWARWEISNFEYLMQLNTLAGRSYNDITQYPVFPWILSDYSSSTLDLSNPSSYRDLSKPIGALNADRLMKFQERYSSFDDPVIPKFHYGSHYSSAGTVLYYLVRLEPFTTLSIQLQGGKFDHADRMFSDIVATWNGVLEDMSDVKELVPELFYLPEVLTNENSIDFGTTQLGEKLDSVRLPPWAKNPVDFIQKHRMALESEHVSAHLHEWIDLIFGQQRGKEAIQANNVFFYITYEGTVDIDKILDPVQQRATQDQIAYFGQTPSQLLTIPHMKRFPLADVLHLQTIFRNPKEVKPYAVPHPERCNIPAAAMLASSDSVITVDLHAPAAHIAEHKWQPNTPDGQGTPFLFQHGKPNASSAGGTFMRMFKGPTGSGPEDWHFPQSLAYSTSGISSSAIVAITCDKEIVTGGHVDNSVRLISVDGAKTLEIARGHCAPVTCVALSPDSSYLVTGSRDATVLLWRLHRASTSRSGGTVEPSTPSSTPTSTSSSTTNTLAEKRRHRIEGPIHVLRGHLGEILCCAVSSDLGIVASCSKSSDMLLHSIKKGRLIRRLRGVEAHAICLSSDGIILAWSKQLNALSTFSLNGTFIARSQLPSASSISCMEVSVYGHFALVGLNPSLDSDGVYDSSTNLKSRAGSESFDIGSNEENRLSIPLPSICFFDLYSLKVFHNMKLGEGQDIMAMALNKENTYLIVSTADKQLIIFTDPALSLKVVDHMLKLGWEGDGLSPLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAY8</accession>
    <name>A0A068VAY8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00001441001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RING-type zinc finger family. LOG2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HG739257">
        <property type="protein sequence ID" value="CDP17704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAY8"/>
    <dbReference type="FunCoup" id="A0A068VAY8">
        <property type="interactions" value="1186"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VAY8"/>
    <dbReference type="Gramene" id="CDP17704">
        <property type="protein sequence ID" value="CDP17704"/>
        <property type="gene ID" value="GSCOC_T00001441001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAY8"/>
    <dbReference type="OMA" id="AANAPYH"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAY8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16789">
        <property type="entry name" value="mRING-HC-C3HC5_MGRN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000115">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase LOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045195">
        <property type="entry name" value="LOG2-like_mRING_C3HC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP17704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="38890" checksum="F8489827DB26C0A5" modified="2014-10-01" version="1">MGNIGSTGVNNRRRSGSRRTHPPPPPPQPPQPEITPRYPNPNAPPPYYQYTGYYPAPPPAMPVPLPAPYDHHHHMDPPHANWVSGRYPCGPMMQPPTPFVENQKAVTIRNDVNLKKETLRIEPDEANPGKYLVAFTFDATVAGSITIIFFAKEGEDCTLTPMKDRLLPPVTVSFEKGFAQKFRQPSGTGLDLSMFEEADLLKEGEMDVYPLAVKAEAFADNQSTSADGNTEPEPGSTNSQITQAVFEKEKGEYQVRVVKQILWVNGMTYELQEIFGIGNSVDSDFDGNDPGKECVICLSEPRDTTVLPCRHMCMCNGCAKVLRFQTNRCPICRQPVERLLEIKVSNAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB29</accession>
    <name>A0A068VB29_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003901001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB29"/>
    <dbReference type="Gramene" id="CDP17782">
        <property type="protein sequence ID" value="CDP17782"/>
        <property type="gene ID" value="GSCOC_T00003901001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB29"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="66" mass="7659" checksum="2E6922A7E36696BE" modified="2014-10-01" version="1">MKTANFEQYNLESLEGLSCGSHNYYEFWEAMDQCALMHSIMLRIRMLTVSCLCICWTISEMLPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBI2</accession>
    <name>A0A068VBI2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pyruvate kinase</fullName>
            <ecNumber evidence="18">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00005604001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="18"/>
    <dbReference type="EMBL" id="HG739276">
        <property type="protein sequence ID" value="CDP17952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBI2"/>
    <dbReference type="STRING" id="49390.A0A068VBI2"/>
    <dbReference type="Gramene" id="CDP17952">
        <property type="protein sequence ID" value="CDP17952"/>
        <property type="gene ID" value="GSCOC_T00005604001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBI2"/>
    <dbReference type="OMA" id="TAMENTC"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBI2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000005">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 18" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="19">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="20">
        <location>
            <begin position="335"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP17952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="464" mass="50600" checksum="86A545AA060CD0E3" modified="2014-10-01" version="1">MNVARFNFSHGTHQYHQETLDNLRTAMQNTGILCAVMLDTKGPEIRTGLLKEGKPIQLKQGQEITISTDYTIRGDENMISMSYKKLAEDLEPNSVILCSDGTITLTVLDCDKKLGLVRCRCENSAVLGEKKNVNLPGVIVDLPTLTEKDKEDILGWGVPNRIDIIALSFVRKGSDLVAVRKLLGEHAKSIMLMSKVENQEGVANFDEILANSDAFMVARGDLGMEIPIEKIFLAQKVMIHKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVANAVIDGTDCVMLSGETAAGAYPEIAIQTMAKICMEAEDSLNYHEVFKRTMENAPMPMSPLESLACAAVQTASSSKAALIIVLTRGGTTAKLVSKYRPSMPILSVVVPEIRTDSFDWSCSNESPAMHGLVFRGVVPVLSSASTRASHTESTKEALDFAIQYAKSKQLCKPGETAVVLYHYESSVIKILTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC04</accession>
    <name>A0A068VC04_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein adipocyte-associated 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00012960001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0359 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739315">
        <property type="protein sequence ID" value="CDP18380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC04"/>
    <dbReference type="FunCoup" id="A0A068VC04">
        <property type="interactions" value="1346"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VC04"/>
    <dbReference type="Gramene" id="CDP18380">
        <property type="protein sequence ID" value="CDP18380"/>
        <property type="gene ID" value="GSCOC_T00012960001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC04"/>
    <dbReference type="OMA" id="DRWKSIN"/>
    <dbReference type="OrthoDB" id="10027388at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC04"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018781">
        <property type="entry name" value="TPRA1/CAND2/CAND8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10160">
        <property type="entry name" value="Tmemb_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35382" checksum="3B8E14C735171BA2" modified="2014-10-01" version="1">MRGLKEALQVVAEATEVTFPLSSKESSSAAAAEAIGGGKYEGWLWECHGIWHSLFLIIPTALFLLYLAFQAKKSVSKLFNGRSHIIIAYYIFLWVVTLLNLLWCSLQAWECTSGKEVAWSILSLFTTSGMLFLEVSLMAFLLQGNYASGQEALTRTFGISGFIVGVDIFLKGLYTFGFGIPLFIDNNEESHRVKWGLWVVHRLLLTGVYGFIFCVYRSRWRERLPARPAFYNYITIMFFLNGLALFACALAANGAAFGLWLNEITTVCYHALYLPLLYVTFLADFFQEDDLNLENVYYSEMKDAGFFDADWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC98</accession>
    <name>A0A068VC98_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00003781001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739237">
        <property type="protein sequence ID" value="CDP17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC98"/>
    <dbReference type="FunCoup" id="A0A068VC98">
        <property type="interactions" value="2859"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VC98"/>
    <dbReference type="Gramene" id="CDP17303">
        <property type="protein sequence ID" value="CDP17303"/>
        <property type="gene ID" value="GSCOC_T00003781001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC98"/>
    <dbReference type="OMA" id="HYESAQE"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="130" mass="14608" checksum="302AADA319972D51" modified="2014-10-01" version="1">MAGRAPVRTMNSAFIAMIADEDTITGFLLAGVGNVDLRRKTNYLIVDSKTTVKQIEEAFKDFTTREDVAVVLISQYIANMIRFLVDSYNKPIPAILEIPSKDYPYDPAHDSVLSRVRYLFSAESVASDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCA4</accession>
    <name>A0A068VCA4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012956001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739315">
        <property type="protein sequence ID" value="CDP18376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCA4"/>
    <dbReference type="STRING" id="49390.A0A068VCA4"/>
    <dbReference type="Gramene" id="CDP18376">
        <property type="protein sequence ID" value="CDP18376"/>
        <property type="gene ID" value="GSCOC_T00012956001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCA4"/>
    <dbReference type="PhylomeDB" id="A0A068VCA4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT BIOGENESIS GTPASE RSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120:SF11">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT BIOGENESIS GTPASE RSGA 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655742" evidence="2">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="181" mass="19823" checksum="1CFFEC1E93190D7B" modified="2014-10-01" version="1">MMIRPISLIRLRTTTFLTVPLSSALFAVDRSHCYFSIFAAATLHHSQNLSQTMSRKPNQPSKNLLKARETIKQLSSLAPALTQDNKPRLSKSQAVGLVAASQANFMRVIVQQLHEEENENELEDFGGGGGKGAAGEGAIGMELLCVVKVVLKKIKRRVLGRGGKGDRGEEKKSKKKKKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCJ2</accession>
    <name>A0A068VCJ2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00006388001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739324">
        <property type="protein sequence ID" value="CDP18461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCJ2"/>
    <dbReference type="STRING" id="49390.A0A068VCJ2"/>
    <dbReference type="Gramene" id="CDP18461">
        <property type="protein sequence ID" value="CDP18461"/>
        <property type="gene ID" value="GSCOC_T00006388001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCJ2"/>
    <dbReference type="OMA" id="FTSSTHY"/>
    <dbReference type="PhylomeDB" id="A0A068VCJ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="266" mass="29402" checksum="2198E2F4BC0B3331" modified="2014-10-01" version="1">MAVSVPGVSPQEMVAIAQETFRRCTSSSSSSSSLPERRGKGVAIFWFRSDLRILDNEALIKAWLSSQALLPVYCVDPRLFTSSTHYFGFPKTGVLRAQFLMESLADLKNNLKSRGLDLLIKQGKPEDILPLLAKAHGAHTVFAQKETCSEELNVERLVAKNLRQVDQPLLKGLSTKPESKTGTKLQLIWGGSLYHIDDIPFDCKCLPDVYTQFRKSVESKSTVRACLKIPTTLGPPPNISDWGTVPEITELGFQKPKACLLSSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCW4</accession>
    <name>A0A068VCW4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NusB/RsmB/TIM44 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00012401001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739340">
        <property type="protein sequence ID" value="CDP18571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068VCW4">
        <property type="interactions" value="1074"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCW4"/>
    <dbReference type="Gramene" id="CDP18571">
        <property type="protein sequence ID" value="CDP18571"/>
        <property type="gene ID" value="GSCOC_T00012401001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCW4"/>
    <dbReference type="OMA" id="VAPPNWK"/>
    <dbReference type="OrthoDB" id="1897242at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCW4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="entry name" value="NusB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078:SF3">
        <property type="entry name" value="ANTITERMINATION NUSB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="N UTILIZATION SUBSTANCE PROTEIN B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NusB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB/RsmB/TIM44" evidence="6">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="23635" checksum="D199089A89C076DE" modified="2014-10-01" version="1">MLPKIDKSGRFCSPRAARELALLILYASCLEGSDPVRLFEKRINARREPGYDFDKESLVEYNHMSFAGPPVTANTLEEADELLLHDQKESEIEAEVLSAPPKLVYSKLILRFTRKLLVAVAEKWDSHVFVIDKVAPPNWKNEPAARILELSILHLAMSEIAVLGTRHQIVINEAVDLAKRFCDGAAPRIINGCLRTFIKDLQGTSAVKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEG1</accession>
    <name>A0A068VEG1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008256001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739291">
        <property type="protein sequence ID" value="CDP18088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEG1"/>
    <dbReference type="STRING" id="49390.A0A068VEG1"/>
    <dbReference type="Gramene" id="CDP18088">
        <property type="protein sequence ID" value="CDP18088"/>
        <property type="gene ID" value="GSCOC_T00008256001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEG1"/>
    <dbReference type="OrthoDB" id="10251131at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14670" checksum="7AED124903FAD31D" modified="2014-10-01" version="1">MADKAVTIRTRKFMANRLLSRKQFIIDKLARMYEIKDPNAIFVFKSRTHCGGGKSTGFGLIYGFVENAKKYEPKYRLIRNGLDTKVEKSRKQLKERKSRAKKICGVKKTKVGDATEAGKKEIFSWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VER5</accession>
    <name>A0A068VER5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003173001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739509">
        <property type="protein sequence ID" value="CDP19315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VER5"/>
    <dbReference type="Gramene" id="CDP19315">
        <property type="protein sequence ID" value="CDP19315"/>
        <property type="gene ID" value="GSCOC_T00003173001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VER5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="85" mass="8867" checksum="C3C26F2A22E57C8A" modified="2014-10-01" version="1">MVVFSAEGGVSKNCPSVASWSVKVERAVKSTCSIVLVGFLVMVGAVGTSSSTGLETTVRVIARLISANSSAVHILRMLYLSSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEX6</accession>
    <name>A0A068VEX6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(+)-neomenthol dehydrogenase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00009377001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP19124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEX6"/>
    <dbReference type="STRING" id="49390.A0A068VEX6"/>
    <dbReference type="Gramene" id="CDP19124">
        <property type="protein sequence ID" value="CDP19124"/>
        <property type="gene ID" value="GSCOC_T00009377001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEX6"/>
    <dbReference type="OMA" id="FYFYMST"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEX6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000312">
        <property type="entry name" value="(+)-neomenthol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF73">
        <property type="entry name" value="OS07G0685800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP19124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41382" checksum="F8CA063D00AB438E" modified="2014-10-01" version="1">MAQNLGQISNVCFSKQLSLRPTTAAKTGESSSAPIFIQPPPRSRSTNISSLLSLPLSSIPLSGKIETEKLTRIQRVGAMAVDDVGSPVRYAVVTGANKGIGLETVRQLATAGVTVILTARNENRGKEATSKLHQSGLSNVVFHQLDVLETESIKSLAKFIETEFGRLDILVNNAGASGVVVDEDGLRTLNVDPANWLAGKAVNVVQDVIKTTYEAAKLCLDTNYYGVKNVTEALLPLVQRSTSGARIVNISSLRSELKRIPDDQRRKELGDIDTLTEEKINAILQQFLGDLKHDALEANGWQKMLPAYSISKASLNAYTRVLAKKYPDMCINCVHPGFVKTDINWNTGIMTVEEGAAGPVMLALLPQGGPTGSYFDTTKLAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGT9</accession>
    <name>A0A068VGT9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_855</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013753001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739939">
        <property type="protein sequence ID" value="CDP20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGT9"/>
    <dbReference type="FunCoup" id="A0A068VGT9">
        <property type="interactions" value="1863"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGT9"/>
    <dbReference type="Gramene" id="CDP20045">
        <property type="protein sequence ID" value="CDP20045"/>
        <property type="gene ID" value="GSCOC_T00013753001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGT9"/>
    <dbReference type="OMA" id="HDANYPV"/>
    <dbReference type="OrthoDB" id="1701885at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGT9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040348">
        <property type="entry name" value="POLAR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33476">
        <property type="entry name" value="EMB|CAB62613.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33476:SF7">
        <property type="entry name" value="EMB|CAB62613.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="648" mass="71889" checksum="C3B4BACE3B686FD4" modified="2014-10-01" version="1">MDIWVVAAAAGAGYVAQHWKNFVKSRRSFPDSSCESPTFRPESLSSNQQAKGENSWPCDVLCGKKLEVELFLEKERLARDSSVPDIASTIGDCADCYTHSASNLVPGSSSYEDVHVAREGVGMCGDKDETYQDLSLLPSTQETAVSYGFARKKSSLRSRRTNGQSLKPLNSMESCLLAQLYKERAETAEYSCSSVSSPCTPTIKPFVVTDGSRIISRAIANSCNLSIGSVQSKLHTATNLEDIFGVPRLPSLGSMEFRRKAKTDIEMEQHRRSSLSCGVKGKHQRLQGGTSQGALFFCLGLSLGLISSFLTNKREVDKLSDLLKQTESLVQDLQDELEMKDSLTVKELAVEDSESQDTQNDPFNNGPLHAFSSEEKLNDCDNVYKDQKAEEESFSKIEAELEAELERLELNMSTSRLDRKISNLVELDADYVPDAVEGVLKAGAIARQSGPQPYAEQDRSGSSTTQSAHYAVSPRELTLRLHEVIQSRLEQRIQELEIALQNSQRKVQNMESQQTSYWRQLCKSESACCSTEGSPDFKEPNQADQPVVINLSAEALDADNEPFDEFTKVNELEEADSPSGLNYSHKQELLQTGGQKEYWLHNSNDDIGYDGMEEILIKHIVEQARKGSPVVLNAQRALFSPDENEHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH01</accession>
    <name>A0A068VH01_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">7'-O-demethylcephaeline methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.395</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00005419001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>7'-O-demethylcephaeline + S-adenosyl-L-methionine = cephaeline + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231587"/>
            <dbReference type="ChEBI" id="CHEBI:231589"/>
            <dbReference type="EC" id="2.1.1.395"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:80556"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.395" evidence="7"/>
    <dbReference type="EMBL" id="HG739805">
        <property type="protein sequence ID" value="CDP19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH01"/>
    <dbReference type="FunCoup" id="A0A068VH01">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP19839">
        <property type="protein sequence ID" value="CDP19839"/>
        <property type="gene ID" value="GSCOC_T00005419001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH01"/>
    <dbReference type="OMA" id="AMESDSW"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH01"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000057">
        <property type="entry name" value="O-methyltransferase ZRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="8">
        <location>
            <begin position="103"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="334" mass="37432" checksum="FFA3CF3C4E198546" modified="2014-10-01" version="1">MSVKCAIQLGIPDVIHKHGQPMTLDQLIDALPIKNAKAPFVYRLMQILIHSGFFIEAKIPGNENDNQKGYLLTSASELLLKSNPFSMTPFLLAILDPTLTDPWHHLSQWFQNSDETPFYTCHGRSIYAFASHEPWLNQFFNEAMASDTRLVSRVVTKDCKHVFEGLNSLVDVGGGTGTFAKAIADAFPRLKCTVLDLPHVVDGLESSKNLAYVGGNMFEAIPPADAVLMKWILIDWSDDECVQILKKCKEAIPSKEKGGKVIIVEMFCKSQQKGDDDHEAIETQLCYDMEVMALGKGRQINEKDWAKLFSEAGFCDYKITAVLGLRSIIEVYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VII3</accession>
    <name>A0A068VII3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_1194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00012286001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG740278">
        <property type="protein sequence ID" value="CDP20422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VII3"/>
    <dbReference type="STRING" id="49390.A0A068VII3"/>
    <dbReference type="Gramene" id="CDP20422">
        <property type="protein sequence ID" value="CDP20422"/>
        <property type="gene ID" value="GSCOC_T00012286001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VII3"/>
    <dbReference type="OMA" id="YGFINIW"/>
    <dbReference type="OrthoDB" id="1847170at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VII3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF50">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN ITN1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="9">
        <location>
            <begin position="417"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP20422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="598" mass="67232" checksum="A53F3E416BEF4515" modified="2014-10-01" version="1">MDPELYAGAQSGNWVVMKRFSDYFYSQHTPVKDTVLHVLAQSCDSADVVQLILDRHGRLLMKLNKRGETALHLAARNGHLGIVRALIDYAKSEAGHWFPPCSDRRKRMLRMASVAGNTALHEAVRNNFYDIAKLLVQEDPEFRYPHNYAVETPLYLAVEKGRHNIMVLILESCKAPSYLGPGHKTALHAASIWNLPESMKRILEKLPNLIKNVDKFGWTALHYAAKFDHQEIARLLLSADRSTAYVAAKNDDSKTALHIAVIHGHVVLVQEILSDCPDCWVQITGKSRNILHLAVKHEKREVLELVLQSSWASELINEKDNEGNTPLHLYVATENLDGNCLVNHPFVDVNSFDSSNSTPLDRIVRDDQLSDRKLSTLIYNQYYLTNLLEQAAGTRGYRNVATVKKISRASGPDEVKRVENLSKNYSIVATLIATVTFAAGFTVPGGYNSDGPDKGMAVLGKQADFITFVISDFLAMIAAMGAVLGHIRLVQTKNYRLKLAIVRVTERQISWAVLFMMMAFPSGLCAVLPNLPVTILLCVSIAWFFHDVYINLAIAWLNLEDRECTYTTRFNHSEADDVNLRALGLYKRWYQDLTEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJN9</accession>
    <name>A0A068VJN9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00012341001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741143">
        <property type="protein sequence ID" value="CDP20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJN9"/>
    <dbReference type="FunCoup" id="A0A068VJN9">
        <property type="interactions" value="2321"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJN9"/>
    <dbReference type="Gramene" id="CDP20926">
        <property type="protein sequence ID" value="CDP20926"/>
        <property type="gene ID" value="GSCOC_T00012341001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJN9"/>
    <dbReference type="OMA" id="KMIWWID"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20870" checksum="A297DFF0DE18056F" modified="2014-10-01" version="1">MDLSPPAGENYAHPRICFFHVLFKAAALAFYILSALFVNSFVIIFVITVLLGALDFWVVKNVSGRILVGLRWWNEINDEGESVWRFECLDQESMARINQKDSWLFWWTLYLTAVAWIFLGIFSLIRFQADYLLVVGVCLTLSIANIVGFTRCRKDARKQLQAFATQTLASRVTSTIQSAFSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKD3</accession>
    <name>A0A068VKD3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_2449</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00004188001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741533">
        <property type="protein sequence ID" value="CDP21077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKD3"/>
    <dbReference type="Gramene" id="CDP21077">
        <property type="protein sequence ID" value="CDP21077"/>
        <property type="gene ID" value="GSCOC_T00004188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKD3"/>
    <dbReference type="OMA" id="WIAHATH"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF349">
        <property type="entry name" value="CYTOCHROME P450 716A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP21077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="456" mass="52144" checksum="ECAE4325BD93054B" modified="2014-10-01" version="1">MHAQLNTIYFPGISKRERALMKQITNGLNVLNKSRNPPIHLHASFVLMLPPGRTGWPLVGETLQYFSKIQQGVLEKFVTERRNKYSSKIFRTSLIGYPMAILCDAEGNKFLFSNENKFVKHWWPSTIDKLFPKSNNKPNTEHTKALHKLLTFILKKDVLRAYVGVMDAIMKQHLQIYAECKLVKIGDMAKTYIFKLACITFLGIDNQVKIDELEKGIEEIAAGLHSMPLNFPGTALNRAIKTSKLMREEFESMIRQRKVDLSVHSSSSAKDFVSHMLSATDDGGQFYSEADIACILVGLLQGSYTTVHNTITNIMMYLTEFSDVYNSVLREQKEIADLKEPNNILCWDDLKKMKYSWQVACEVLRLKPPVHGAFKEAIADFNYAGYTIPKRWKIHWIAHATHKNPEYFPDPDKFDPSRFQGDGPASYTFVPFGGGAHMCLEPSMRGLQYSFFCIMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLI3</accession>
    <name>A0A068VLI3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00008908001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="HG743432">
        <property type="protein sequence ID" value="CDP21469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLI3"/>
    <dbReference type="STRING" id="49390.A0A068VLI3"/>
    <dbReference type="Gramene" id="CDP21469">
        <property type="protein sequence ID" value="CDP21469"/>
        <property type="gene ID" value="GSCOC_T00008908001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLI3"/>
    <dbReference type="OMA" id="WPTQADP"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLI3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000003">
        <property type="entry name" value="glucan endo-1,3-beta-glucosidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001659006" description="glucan endo-1,3-beta-D-glucosidase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="372"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP21469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="458" mass="49851" checksum="E1C808BA43A95DEE" modified="2014-10-01" version="1">MATHSSSPAKPFLFSISFVIFLHHFLHHWAVAAGYAIGVNYGTVADNLPPPAQVASFIKDQTSIDKIKIFDANPDIIRAFANSNVSLTITVGNGDVLAVSKLPAAQSWVSTNVLPYYPQTKIHRIDVGNEVIATGDRSLIAHLVSAMKSVHEALRLAGISDIQVSTPHSMGIMSRSEPPSSGRFRRGYDRVIFAPMLEFHRRTGSPFMVCPYPFFGFTSKTLDYALFKPNDGIFDNVTGVNYTNMFDAQMDAVFSAMKRLGYDDVDIVVAETGWPSAGDPNQPGVSLDNAISYNANLVRHVNSGLGTPLMPNRTFDTYIFSLFNEDLKPGISEQNFGLFRPDFSPVYDVGILRNQQGVGPAPVTPAAPDDKKWCVPKDDASDGALQSNIDYVCGSGVDCQPIQNGGPCFEPNTVRSHAAYAMNAYYQAHGRNDYNCDFIGTAAITTANPSYQGCTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLK8</accession>
    <name>A0A068VLK8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_5487</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00010606001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG744571">
        <property type="protein sequence ID" value="CDP21660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLK8"/>
    <dbReference type="FunCoup" id="A0A068VLK8">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLK8"/>
    <dbReference type="Gramene" id="CDP21660">
        <property type="protein sequence ID" value="CDP21660"/>
        <property type="gene ID" value="GSCOC_T00010606001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLK8"/>
    <dbReference type="OMA" id="KWKLAGG"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLK8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24281">
        <property type="entry name" value="STEROID 21-HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP21660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="500" mass="57094" checksum="442A4C8C8A8CE73A" modified="2014-10-01" version="1">MNCTSGLRVDSRLRFTSMSWIPYFSGFMALVLLVFTMGKWIMICLKNNKPRFPLPPGPKPLPFFGCIFQMLRNRPTHRWIYKVMDDMNTEIACFGIFGVHIIPVTSPELAREFFKKHDSIFSNRPVCMSAELSSEGFLTTGLSPLGDQYKKMKRMIVSMDIRLATRHYLGNVIRKMIFNKRFFGKGMEDGGPGAEEVEHVNALFKLLAYMYAFSLSDYMPWMKIFDFDGHRKVLTMAIACVRRHHDPEIEKRIKTWESGLKNEEEDLLDVLIRLKDNKGRPLLTTEEIRAQITELMFATVDNPSNAVEWALAEMLNQPEMLQKATEEIDTVVGKDRLVQESDLARLKYVKACAKEALRLHPYAPFNVPHVSTQDTVVGGYFIPKGSHVILCRPGLGRNPRIWGDSLKFKPERHMNDMDDARMDLNDPELNMFSFSTGRRGCPGVLLGSTLTVMLLARLLQCFNWKIPSGLSQIDLAEGMDAGFLAKPLFAVAEPRFPQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLM9</accession>
    <name>A0A068VLM9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_5219</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00005432001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
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                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
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                <person name="Giuliano G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">cv. DH200-94</strain>
        </source>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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    </dbReference>
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        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
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    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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    <feature type="chain" id="PRO_5001655956" evidence="7">
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            <begin position="24"/>
            <end position="311"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="176"/>
            <end position="194"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="8">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP21597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="311" mass="33600" checksum="920028DBDB73C802" modified="2014-10-01" version="1" fragment="single">YIKICVGFFLVFFACKEPASVFAQLSLKEGLTVFRDPEFSSDVGSSTVKRIADVLKLRIYQYPLVYKAVLVAYDLAPETAILLTLDHEGSVINEEEIDSRLIQKNDVIKIFPGAKVACDGFVIWGQSHVNESMITGESRPAAKRKDDVVIGGTVNENGVLHIKATKVGSESALSQIVRLVIVLSFSTWLAWFLAGKFSGYPKSWIPSAMDSFQLALQFGISVMVIACPCALGLATPTAVMVGTGVGASQGVLIKGGHALESAHKVNCIVFDKTGTLTKGKPVVVSTRLLKNMVLREFCELVAAAEVNSRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN10</accession>
    <name>A0A068VN10_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_9849</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00007650001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG748933">
        <property type="protein sequence ID" value="CDP22076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN10"/>
    <dbReference type="STRING" id="49390.A0A068VN10"/>
    <dbReference type="Gramene" id="CDP22076">
        <property type="protein sequence ID" value="CDP22076"/>
        <property type="gene ID" value="GSCOC_T00007650001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN10"/>
    <dbReference type="OrthoDB" id="1932324at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN10"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF8">
        <property type="entry name" value="RIBOSOMAL L18P_L5E FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP22076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="96" mass="10715" checksum="40A0F1B5BC8DB46F" modified="2014-10-01" version="1">MVPGSLDQFNGTATKPRLSVFCSDKQLYAMVVDDQNERCLFYGSTLQKSIRQDPSCTTIEAAQRVGEELVKACIDLDINEISSFEIAISRHGFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN23</accession>
    <name>A0A068VN23_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_9204</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00002704001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748288">
        <property type="protein sequence ID" value="CDP22027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN23"/>
    <dbReference type="Gramene" id="CDP22027">
        <property type="protein sequence ID" value="CDP22027"/>
        <property type="gene ID" value="GSCOC_T00002704001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN23"/>
    <dbReference type="OMA" id="MDIESIV"/>
    <dbReference type="OrthoDB" id="122245at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN23"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF218">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPS2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="213"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="466" mass="52602" checksum="B68F226A8F838656" modified="2014-10-01" version="1">MSGFENLPCGISRLTQLQHLALPSMKEDIQAADTSEVTSWKQKPSASHWSFSVVDRTVPNTSRSLLSYNGSLFLEFLDSNPSVLDSTSNHFHLFVHPTEVQNGARDMLFHRDELVCRDVYLLTRHCSKSEGRLVEIHHLSAFSEGIEVVLHDAEYIFFFDSLFFKSFSDLGAGNIKTLKGCWIEGCENMEFVIETSDLVGSSERGIALEILWISNASSLRSMYSENLRLGSFQNLKCLYLDCCPKLLSVFFSSHLLQMLEILHVRFCENLVALFGDDVEEHELPNLRTLRLWELPKLKSIGCIMPSLQSLEVGECPMLEHMLSSLHVPEKLEVLKVRNCSELGNLLEGLTPENCKLPHLAEVHLWGLPKLTRIGIESPLLRSLEIGDCYVLLHVSYMPENLEVLKVRFCDNLEAIFVGMTSENFILQSLHTVHLWGLPKLVGIGARLPPLQKSIIRDCPKLALPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN90</accession>
    <name>A0A068VN90_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00000813001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG751163">
        <property type="protein sequence ID" value="CDP22205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN90"/>
    <dbReference type="Gramene" id="CDP22205">
        <property type="protein sequence ID" value="CDP22205"/>
        <property type="gene ID" value="GSCOC_T00000813001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN90"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN90"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="277" mass="32239" checksum="5097964B022B91FD" modified="2014-10-01" version="1" fragment="single">MLYAFSFSPAEGTRVKTSPPELVSANDSKKKLLILDLNGVLLGSAFTRMTRNRDFNFKPRCFEFLKVCLSYFEVAVCCAFWSHNIQPMLDSLSKKMNERLEQRLLFVWDQSRCTMTQTSLRENPDKPVMFKDLKHVWGEYKSYNSSNTILVDDSPYKSFLNSPYNAIFPTSYTCYTVEDNYLDPEGDFVRHLKKLASADNVQDFIKRSRFGQSPVTEGSVEWNFYVNVFSKLGLQNTAKQVTRRREAPNRYYPEVSIAFMFRNMFTIVQHLVMIAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VR52</accession>
    <name>A0A068VR52_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_11710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00005762001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG750794">
        <property type="protein sequence ID" value="CDP22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VR52"/>
    <dbReference type="STRING" id="49390.A0A068VR52"/>
    <dbReference type="Gramene" id="CDP22183">
        <property type="protein sequence ID" value="CDP22183"/>
        <property type="gene ID" value="GSCOC_T00005762001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VR52"/>
    <dbReference type="PhylomeDB" id="A0A068VR52"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1139">
        <property type="entry name" value="CC-NBS-LRR RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="246"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="320" mass="36234" checksum="19BA53E84AE100B2" modified="2014-10-01" version="1" fragment="single">MADALLGSTVQVLVEKAINMASEQIGLFVGFKNNLEKLMYGLTLIKPVLHDAEEKQVTQEFVKRWLEKLEAVAFDAGNLLDDINYEMIRRRVEIQNQMNKKVCFFFFSLSSPIAFRCNLMANKIQQINMDLNRINEGAMNFSLQSQIGARDVPALSPPSGEGFVKNSEIDSVTIDTSFIGRGDDVSAIVTQLTATSSNETLSVLPLVGMGGIGKTTLARKVFNELKIDIHFDKKNMGLCCFAYCTIYSKDFQMERSQLIRLWMAEGFLHSNQRNNMRMEEVGNMYFMILLDSNLFQDAEKDDYGNVLNCKMHDLVHDMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLI8</accession>
    <name>A0A068TLI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014332001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fasciclin-like AGP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLI8"/>
    <dbReference type="FunCoup" id="A0A068TLI8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLI8"/>
    <dbReference type="Gramene" id="CDO97096">
        <property type="protein sequence ID" value="CDO97096"/>
        <property type="gene ID" value="GSCOC_T00014332001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLI8"/>
    <dbReference type="OMA" id="HIVPNRY"/>
    <dbReference type="OrthoDB" id="765989at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052806">
        <property type="entry name" value="Fasciclin-like_AGP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33985:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33985">
        <property type="entry name" value="OS02G0491300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654073" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="244"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="397" mass="42518" checksum="3B6DAF30B1CABB9F" modified="2014-10-01" version="1">MAAISLKQKPLVLAFVLYLSISATASAFTSSAPSFPPSVNQPELLTYPTTLIASILSTLGFQELSSAAVDANLSTSTPITIFAPSDSSLLTCPSCSLPLLLQEHAVPGLYPNHFLRNLAFGTKLETLASGHCLTITSSAAQNVSTRVVFVNGVEISEPDLFNNGVFLIHGLRGFVSHLSPLSCNVERMTTLSFPQPSLHKSPLSSIMRLMLKDAIIRLRFGGYSIVSLALKVKFGELSELKSMTVFALDDISIFSGAGYAYLHHFRFHVVPNRRLMAADLLSLQAATTLPTMEIGQNLVVTAAGGGGQFSPVKINYVKVTTMDLLHNSRIVVHAVSTAFPRMHHHLSLTDGAAVEEAYRPPCDISLDGGFCDVAAPVPAGIRSTPDIIGRLDDRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLM4</accession>
    <name>A0A068TLM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00014050001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLM4"/>
    <dbReference type="Gramene" id="CDO96882">
        <property type="protein sequence ID" value="CDO96882"/>
        <property type="gene ID" value="GSCOC_T00014050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLM4"/>
    <dbReference type="PhylomeDB" id="A0A068TLM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO96882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12040" checksum="2606D5A4D4768F40" modified="2014-10-01" version="1">MKAVGENKKWNAIGGLSDTKANLQGLGGTKTAQNVDKAVPRDVQEMAEFAVEGTKLVLIKVKRVVVFGGFYSLHMLTQDDKGTYTDKALALKFKNGKKVRLWYKHNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLP9</accession>
    <name>A0A068TLP9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00014017001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLP9"/>
    <dbReference type="FunCoup" id="A0A068TLP9">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLP9"/>
    <dbReference type="Gramene" id="CDO96859">
        <property type="protein sequence ID" value="CDO96859"/>
        <property type="gene ID" value="GSCOC_T00014017001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLP9"/>
    <dbReference type="OMA" id="VHPMPIE"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000010">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000054">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF126">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO96859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="799" mass="90153" checksum="194AC1FCA9F1F5C7" modified="2014-10-01" version="1">MMSRSYTNLLDLASGNFPVMGRERGERKRLPRVMTVPGVISELDDDQANSVSSDVQSSVAVDRVIIVANQLPVKAKRRPDNVGWSFSWDEDSLFLHIKDGLPDDMEVIYVGHGGRFDRSWWEAYVAANKIFSQKVIEVINPDDDYVWIHDYHLMVLPTILRRRFNRLRMGFFLHSPFPSSEIYRTLPLREEILKALLNADLIGFHTFDYARHFLSCCSRMLGLEYQSKRGYIGLEYFGRTVGIKIMPVGIHMGQIESVLKFADKEWRLEELKQQFAGQTVLLGVDDMDIFKGVNLKLLAMEQMLNQHPKWLGRAVLVQIANPARGKGKDLEEIQAEIQASCKRINDNFRQPGYEPIIFIDRPVSLSERAAYYTAAECVVVTAVRDGMNLTPYEYIVCRQGIPGSESTSDSNSPKKSMIVVSEFIGCSPSLSGAIRVNPWNVEATAEALHEAISMQDAEKQLRHEKHYKYVSTHDVAYWSRSFFQDLERTCKDHFRRRCWGIGLSFGFRVVALDPNFRKLSIDDIVSDYSRAKNRAILLDYDGTVMPQTTISKIPSQEVISIFNKLCSDVKNTVFLVSGRGRDSLGKWFSPCKNLGIAAEHGYYLRWPSDGEWEMCGQSNDFGWMQLAEPVMQLYTESTDGSYIENKESAIVWHHRDADPGFGSSQAKEMLEHLESVLANEPVAVKSGQFIVEVKPQGVSKGVVAEKIFASMTERGRQADFVLCIGDDRSDEDMFEIIGDAMNSGVLSSNTSVYACTVGQKPSKAKYYLDDTSEVIMMLEALADASDSVPSSVAFTESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLZ0</accession>
    <name>A0A068TLZ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">COBRA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00014156001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COBRA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLZ0"/>
    <dbReference type="STRING" id="49390.A0A068TLZ0"/>
    <dbReference type="Gramene" id="CDO96959">
        <property type="protein sequence ID" value="CDO96959"/>
        <property type="gene ID" value="GSCOC_T00014156001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLZ0"/>
    <dbReference type="OMA" id="HWHIKNN"/>
    <dbReference type="OrthoDB" id="1554693at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLZ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010215">
        <property type="term" value="P:cellulose microfibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052324">
        <property type="term" value="P:plant-type cell wall cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056900">
        <property type="entry name" value="COB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006918">
        <property type="entry name" value="COBRA_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673:SF41">
        <property type="entry name" value="COBRA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673">
        <property type="entry name" value="PROTEIN COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25079">
        <property type="entry name" value="COB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04833">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038122">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="COBRA C-terminal" evidence="9">
        <location>
            <begin position="269"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO96959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="442" mass="50290" checksum="363E2E4A83050B07" modified="2014-10-01" version="1">MELLLYRLCCSNLFYVLLVIIICRLSGTSLFLESLIADCYDPLDPNGNITVSFDILQYTSDGYVVGIMIISLLFLAPSNFISVTIQNFYLYRHVDKPGWRIGWTWSQNEVIWSMSGAFATHQGNCSSFKFQTPHSCMKYPDILDWMPDALPQNRSDACCKGGILDAWAINPSKSFSSFEMTVGNLGGNPTGYRPLNLTLLAPGPGYTCSPIIDTDPTVSSVVGGRREEQGHGNQHAHSRVIWLTRRQSVVFHSQHFTMLPLLHSRTLDTDILQCTDHMCPLRVHWHIKNNFLDHWRVKLTISNYNLGRNYSNWNVLVQHPGFSQNSTSYSFNSIVLPTIGVPDEVALFWGIEYYNDELLQADKVQVGSVTTEILLRKDMDSFTLRNGWAFPRRIYFNGENCEMPLPDTFPMLPNGGSRIDPPHWSLLPIMVYLTYKISGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM39</accession>
    <name>A0A068TM39_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00014738001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM39"/>
    <dbReference type="STRING" id="49390.A0A068TM39"/>
    <dbReference type="Gramene" id="CDO97400">
        <property type="protein sequence ID" value="CDO97400"/>
        <property type="gene ID" value="GSCOC_T00014738001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM39"/>
    <dbReference type="OMA" id="DDDRRCM"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM39"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="353"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO97400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="534" mass="61085" checksum="7383669890BAC472" modified="2014-10-01" version="1">MAKGVTSEPERIASSNLNNKPRYSKQHTRSSSSKISQFLHYSPKLSLYFLVTFTFLLILFQIQPLQIPSLPPTTNSWTFMSRWQNVINNTNLSTLAKQYCAKDLESTASKLRDAVTFLPLKDLRYTSSAQQGHTWFMSSMYDTHEEGEVQYQQFPSEASKGRLLCLKGRDTHEGAWNSYALAWPDTLPHNATLLKGLTFVSYNHYNYDNIWHGLSAMVPFVAWHIKNGCAAPTRWVLYHWGELRMKMGPWLRALMEATFGEPLYVEGFTHDQEVGGPDDHGNNDDDDDENPFCFEEAVVMRHNEGGMSRQRRIEVYDLLRCKARIYCNVSIEGRNAEADEKAGVPVIGMTMFMRTGARSFRNPSAVIAIFEKECNMVEACRFRVAYSNNLTFCEQVKLMSSTDILISPHGAQLTNMFLMDRNSNVLEFFPKGWLKLAGVGQYVYHWIASWSGMKHQGAWRDPDGEKCPYPEDDRRCMSIFKSGLIGHNQTYFSEWARNVLDDVKMRKMEELASLMKKNSANTKTTIVSGCPLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMI4</accession>
    <name>A0A068TMI4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014803001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMI4"/>
    <dbReference type="FunCoup" id="A0A068TMI4">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMI4"/>
    <dbReference type="Gramene" id="CDO97456">
        <property type="protein sequence ID" value="CDO97456"/>
        <property type="gene ID" value="GSCOC_T00014803001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMI4"/>
    <dbReference type="OMA" id="GNERWDS"/>
    <dbReference type="OrthoDB" id="1930465at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMI4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36080">
        <property type="entry name" value="DBJ|BAA96220.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36080:SF1">
        <property type="entry name" value="DBJ|BAA96220.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15390" checksum="D333D0DB2D71EE17" modified="2014-10-01" version="1">MEERDKEKAKGSERWTAAITNLSEIAANLDSLQKLLMKKAVYVLEQRVETLERELDAAISAAARARNEKRQAEAAQKAAELRALEVTRELENTTKVFELHMEELRAKQEEISKRDNEIKLLEAIIQTLGGRESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMP3</accession>
    <name>A0A068TMP3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015003001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YTHDF family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDO97615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A068TMP3"/>
    <dbReference type="FunCoup" id="A0A068TMP3">
        <property type="interactions" value="1485"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMP3"/>
    <dbReference type="Gramene" id="CDO97615">
        <property type="protein sequence ID" value="CDO97615"/>
        <property type="gene ID" value="GSCOC_T00015003001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMP3"/>
    <dbReference type="OMA" id="QDFQTEY"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF95">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="3">
        <location>
            <begin position="347"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="569" mass="63442" checksum="9D707DF074653BD5" modified="2014-10-01" version="1">MAGERIIENSEQMVQGLKPDSAAVKPEKDMASNKNGLASDTASPLPTLGDVTTGLKGDNQNLDAEQGVYYPPTSCYNYYYPGYNGTFNQLDDQGYLAMGGGYSGIPSDNSSLLYYLPGYNPYNTGFIGADGEQLPYVSSGYFQQPVSYGSEALPPHTWDSMYVGDVKNRVVSKTDDVKAAFGQNESVNSSVINSSKTINSSSTVPLNSKARKFTLPSDFCKSFPHTRPLKPLNKLGPGFPSIENMNGVYPAGKLSAFSNQNRGLYMHYGPMNYQPNGRVWNTYQRSRSRSNFRREGENEASNELSRGPRANGKSEHSKLSADDEQAELTVQRDKYNLEDFQCEYDNGKFYVIKSYSEDDIHKCIKYDVWSSTPNGNKKLDAAFRDAEFKATEKGTKCPIFLFFSVNGSGQFLGVAEMVGQVDFNKNMDFWQLDKWNGFFPVKWHIVKDVPNSLLRHIILENNDNRAVTYSRDTQEIGLKQGLEMLSIFKSYSAKTSLLDDFKFYGGREKSLKAHRSTKPTLQTDVLKEDDSPKPLKEGCKTNGTDLMPSLVNLTKDLSLNPPLPLKSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNY3</accession>
    <name>A0A068TNY3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CHUP1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00021913001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNY3"/>
    <dbReference type="FunCoup" id="A0A068TNY3">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNY3"/>
    <dbReference type="Gramene" id="CDO97961">
        <property type="protein sequence ID" value="CDO97961"/>
        <property type="gene ID" value="GSCOC_T00021913001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNY3"/>
    <dbReference type="OMA" id="NDRHKEM"/>
    <dbReference type="OrthoDB" id="1870283at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072699">
        <property type="term" value="P:protein localization to cortical microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040265">
        <property type="entry name" value="CHUP1/IPGA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342:SF4">
        <property type="entry name" value="ACTIN BINDING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
        <property type="entry name" value="PROTEIN CHUP1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="212"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO97961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72042" checksum="2175A9FD593EAFD1" modified="2014-10-01" version="1">MTREKRDIRPVLFKLGVALAFSVGSILFSILRTKKVKPSGSPPSQPSHPEHPNQADSVEERIELKNDEDDHVLLRATSSCNFALASSERDEPSLLSKTSSGCLSGNCSPSKRSNGDKDVYLLPEFNDLVKEFDLAAMKATFSPHKDVEMLTNSCVQKLDHEQELNSLRNMVKTLKERERSLEIQLLEYYGLKEQETAVMELHNRLKINNMEAKLFNLKIESLQADKRRLEEQVADYARVVSELEAAKTKIKLLKKKLRSEAEHNREHILALQERVVKLQDQEKKALCTDSDLQLKLQQLKDYEEEAEELRKSNHILRQENSALAQKLEYVQTLAVSVLDGEKVEALKSESNRLRQENEDKAREIEQLQAARCSDIEELVYLRWINACLRYELRNYQPDPDKTVARDLSKSLSPKSEEKAKQLILEYARKEGTGEKGISIADFDSDRWSSSQASYLTESGENDDLSVECSSTNKTNTSSKTKIFGKLRQLLRGKGSSHLRRSSSLESAPSMEYIVGKSSSISPVCNAGVSPGTAFGDDGLNARSRTSSQSSSRLSLDLQRFPYLQGSKSGKGEESSNLECIQRNSSEGSSYVTNLSKENQYQHQQSSTDAKKSELLKYADALKDSRRKPTVRKRSVSCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ23</accession>
    <name>A0A068TQ23_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022404001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ23"/>
    <dbReference type="Gramene" id="CDO98341">
        <property type="protein sequence ID" value="CDO98341"/>
        <property type="gene ID" value="GSCOC_T00022404001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ23"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="34" mass="3876" checksum="3C7086BD12759F85" modified="2014-10-01" version="1">MHRTKVIISRFRDRLLCANLLCILGAKLYTALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRX9</accession>
    <name>A0A068TRX9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00025703001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRX9"/>
    <dbReference type="FunCoup" id="A0A068TRX9">
        <property type="interactions" value="3129"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRX9"/>
    <dbReference type="Gramene" id="CDO98782">
        <property type="protein sequence ID" value="CDO98782"/>
        <property type="gene ID" value="GSCOC_T00025703001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRX9"/>
    <dbReference type="OMA" id="HFFYKHC"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRX9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="40"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO98782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="759" mass="85528" checksum="00EE2C0B28826772" modified="2014-10-01" version="1">MHFNTLSNETYHNVNSELRELPPVELSTLPLILKIIVESGIADQLRVTDLILHDLEFIRKLMDLFRICEDLDNIDGLHMVFKIVRGIILLNSTQIYDRIFGDEYIMDIIGCLEYDPDVPHVHHRNFLKENVVFKEAIPIKDSVVLSKIHQTYRVGYLKDVILPRVLDEATVASLNSIIHSNNATVVSLLKDDNTFIQELFARLKSSSTSAESKKNLVLFLHEFCSLSKSLQMVHQLRLYRDLVNEGILEIIADILQSQDKKLILTGTDILILFLNQDPNLLRSYVTRQEGIPLFGLLVKGMLTDFGDDMHCQFLEILRNLLDSYTSGSQRESIIDIFYEKHLGHLIDVITSSCPPNSAAQAVSKSGRSDEESGNQISVKPEILLNICDLLCFCVLHHPYRIKCNFLLNSVIDKVLLLTHRREKYLVVAAVRFIRTLISRNDENLLSHIVKNNLLKPIVDAFVSNGSRYNLLNSAVLELFEYIRKENLKILLKYLVDSFWEQLAQFDNLPSIRSLKVKYEQALESAGLRSNTNVLDPRKRIDDRALEKEEEDYFNDDSDEEDSASASTPSRKRAQSQPNLPNGSATTYPSTRSGGLVDYDDDEDDEDYKPPSRKRADNSGEDDEVESFRLKRKLATKDEPEPKKLQRSHKSSKPNEGVFAALCSTLSQAVLPGKKTISTAPDILRTDGGKNPVEANHEEKGHKGSSDQGKSSDVDNLADQEEVSPRCFTDGLCGSPDNGQHGDDGPLIPKASPEMAVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS25</accession>
    <name>A0A068TS25_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00026080001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS25"/>
    <dbReference type="FunCoup" id="A0A068TS25">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TS25"/>
    <dbReference type="Gramene" id="CDO99061">
        <property type="protein sequence ID" value="CDO99061"/>
        <property type="gene ID" value="GSCOC_T00026080001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS25"/>
    <dbReference type="OMA" id="EFEEYSF"/>
    <dbReference type="OrthoDB" id="1932324at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS25"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF7">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="384" mass="43548" checksum="723937C915EFBE62" modified="2014-10-01" version="1">MTSMFRRVATTLRSLAYPRNLSLAYSKFSRPSTAFPAKEAESVHTPPDNNQKGDSFGNYTNRIQLSPLCSESSGHHLQDCKIELVDNESWQMSSGLIEAWKGKTKLGCEEKAFLSEEEEDKYNGVLSYVPPNKEDPDFDEIEDMRIRGNLFYKLDKDSKEYEEHKFDFHRKKSSKNKNDQKENTKKEKQNHNVAAGIEKNSIKFKDELKDMKKKEKLCSNSGLAKERYHGVDRNEDLIAGINEVGGDFDGKRLRTPTFNQLTAPYHEPFSLDIYVSKGSVRASIIHRATSKVVAVAHSISKDMKFDLGSTKNRTACAAVGEVLAQRALADDIHNVVYTPRKGEKLEGKLQIVLQSIIDHGVNVKVKIKQRKVRKGGLFQPKTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSE4</accession>
    <name>A0A068TSE4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025856001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSE4"/>
    <dbReference type="FunCoup" id="A0A068TSE4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSE4"/>
    <dbReference type="Gramene" id="CDO98899">
        <property type="protein sequence ID" value="CDO98899"/>
        <property type="gene ID" value="GSCOC_T00025856001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSE4"/>
    <dbReference type="OMA" id="WAVHKLA"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSE4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000028">
        <property type="entry name" value="Glutaredoxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO98899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="102" mass="11014" checksum="D8751C44CE314B98" modified="2014-10-01" version="1">MDSIVKLASQKAVVIFSKSSCCMCHAIKRLFYEQGVSPMIYEIDQISNGTEIEWALIRLGCNPSVPAVFIGGNFVGSASTVMTLQINGSLKKMLKGAGALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSI2</accession>
    <name>A0A068TSI2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025912001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSI2"/>
    <dbReference type="FunCoup" id="A0A068TSI2">
        <property type="interactions" value="1720"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSI2"/>
    <dbReference type="Gramene" id="CDO98939">
        <property type="protein sequence ID" value="CDO98939"/>
        <property type="gene ID" value="GSCOC_T00025912001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSI2"/>
    <dbReference type="OMA" id="WQSEELS"/>
    <dbReference type="OrthoDB" id="514967at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSI2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1100.10">
        <property type="entry name" value="Transcription factor, SBP-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044817">
        <property type="entry name" value="SBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004333">
        <property type="entry name" value="SBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036893">
        <property type="entry name" value="SBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31251">
        <property type="entry name" value="SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31251:SF108">
        <property type="entry name" value="SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26102">
        <property type="entry name" value="Ig_SPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03110">
        <property type="entry name" value="SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103612">
        <property type="entry name" value="SBT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51141">
        <property type="entry name" value="ZF_SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SBP-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="781" mass="86636" checksum="12689E8879C69E7C" modified="2014-10-01" version="1">MISAFLEDPTNSSLFDWSDFLDFNIDVEPFASAPFAADQQQQEGPVSPSDSDQVSPPAEDPGRVRKRDPRLVCTNFLAGRVPCACPELDEKLELEEVTALGGPGKKRPRTVRVPAGSNARCQVPGCGADISELKGYHKRHRVCLQCANAGAVVLDGQSKRYCQQCGKFHILSDFDEGKRSCRRKLERHNNRRRRKPNDPKGTVETEHQQTTVAEDVSGDDDAGKDGICLSSENAEKETLLESEGQQSTLCSAHDSQNIQNNSIVTSGSYGDTQIYGEKENPKYSRSPSFCDNKNAFSSVCPTGRISFKLYDWNPAEFPRRLRHQIFQWLASMPVELEGYIRPGCTILTVFIAMPKFMWVKLSEKPAECLHNLVLSPGSMLSGRDTFYIYLNNMIFRVIKGGSSLFKVKVNEQAPKLHHVHPTCFEAGKPMEFVACGSNLLPSKLRFLVSFTGKYLAHDLCVSSSCGKTEGDAGTLNHHSFKISVPQTEPGIFGPAFVEVENEFGLSNFIPVLIGDKEICAEMNIMQQRFAAKPCIKGLQLSATSSCGVSDLRQTEFSEFIMDVAWSLKKPVMKSSTQFLTSVQIKRFTNLLNFLIENESTAILDRVVYYTRVLIDNNFVATNITDADMEHLWMNLDKARDILHQKLRRNEHQLNNSRKFLLGERSFNRSSLDHMSSVATSNSQGEEVTSKAKLAARVDISSHEGGTTVPLLTGEVVMRVNVSERPGKSCSPLLIKTGFSSRPLIFAVTAATVCIGLCAVLFHPETVGEVATTIRKCLQQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTT6</accession>
    <name>A0A068TTT6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029063001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTT6"/>
    <dbReference type="Gramene" id="CDO99472">
        <property type="protein sequence ID" value="CDO99472"/>
        <property type="gene ID" value="GSCOC_T00029063001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTT6"/>
    <dbReference type="OrthoDB" id="812961at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTT6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044809">
        <property type="entry name" value="AUF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31215">
        <property type="entry name" value="OS05G0510400 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="374" mass="41133" checksum="CDAD213B054C571E" modified="2014-10-01" version="1">MENLGFANLTLGAAAAVEEHQGKANDDPFERLSDELIVSHILDKVSEAKYLCRCSLVSKRFSSLVFVSKSVSLKIPVEMPVVQPDPTPRLAAFPGKPVHAVTYPMGFLQLKAYKCIRGGSSPPHCAFDADLMLDYLPKFLGKFTELKSLAVEFDYSASGVDGNLNFAKQPVIKWTFDPEAWCFVLVIAPRSIDEVGENIYARESDLHQIVSDVHVGIFVCSCIIMGGLVRLLSESLAQVVITDSKKQGRIDFGETDIVEITSKVRPFMTAEEDSKLLLKIWEESTFEQLQEMHAISAAFASLPAPDMKVTSFFLGKGKAKGKGKGNKGKGKSKARGNEGDCDDDYQEVKKAFQGPQAFCLNAVMEMLKEIRGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWH4</accession>
    <name>A0A068TWH4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00032657001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="3"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWH4"/>
    <dbReference type="STRING" id="49390.A0A068TWH4"/>
    <dbReference type="Gramene" id="CDP00645">
        <property type="protein sequence ID" value="CDP00645"/>
        <property type="gene ID" value="GSCOC_T00032657001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWH4"/>
    <dbReference type="OMA" id="AQECISK"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWH4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000009">
        <property type="entry name" value="Cysteine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF26">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE 1, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="37"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP00645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="539" mass="61265" checksum="359A99A912D6906D" modified="2014-10-01" version="1">MAEKIVEEKKKPEGKKAADKKPEFQLYNSMSKQKEVFRPKEEGKVGMYVCGVTAYDYSHIGHARAYVAFDVLYRYLKYLGYEVVYVRNFTDVDDKIIKRANENGEDPISLSGRFCEEYLKDMDDLQCLPPTHQPRVSDHIDEIKRMISQIISNGCAYAVDGDVYFSIDKFPDYGRLSGQNLDGNRAGERVAVDSRKRNPADFALWKAAKPGEPSWDSPWGPGRPGWHIECSAMSAHYLTHTFDIHGGGMDLIFPHHENEIAQSCAACSESNVTYWLHNGFVTVDDEKMSKSLGNFFTIREVTKLYHPLALRHFLLGMHYRSPVNYSILQIEIASDAVYYIFQTLKDAEDALTEFRGKDEIDDAKASISTKAKNCIKNLHDEILTRMSDDLHTSTVLSAALIEALRFINASVETLRKKPQKKKQRQQQQEQQTTVLSLIELEREVKDVLDLLGLLPRLTYSEVLSQLKEKALTRAKLTEDDILHSIEERAQARKNKDYSLSDQIRSDLAVKGIALMDLGKETVWRPCVPVQAANVVDPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXB5</accession>
    <name>A0A068TXB5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032689001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXB5"/>
    <dbReference type="FunCoup" id="A0A068TXB5">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00667">
        <property type="protein sequence ID" value="CDP00667"/>
        <property type="gene ID" value="GSCOC_T00032689001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXB5"/>
    <dbReference type="OMA" id="GCYFVVG"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXB5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000180">
        <property type="entry name" value="Cytidyltransferase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.20:FF:000003">
        <property type="entry name" value="Os01g0691500 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="216"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="383" mass="41818" checksum="6EEED63780B538CA" modified="2014-10-01" version="1">MTDGSMRALVGSIHSCPTQAVLYIAGGASQALGLLLSVPGASNTVLEAVVPYSGMSMIQLLGKVPAQFASAKTAEEMALLAYNRALKLSKPGSPVLGVGFTGSLASTRPKLGDHRFHLSTRTSDQLWVSTVTLSKGLRTREQEETVSSQFLLKGIANACKVEATYISELNESEVPDEYESKFDEDQELEQVINGQICFKVYPFSSDIANTKRKIILSGSFNPLHEGHLKLLDVAISICGDGYPCFELSAINADKRPLTVSQIKERVKQFERVGKTVIVSNQPYFYKKAELFPGSAFVIGADTAVRLIDPKYYGNDYAKMLEILIGCKNTGCVFLVAGRNVDGVFKVLEDFDVPEELKGLFISIPADTFRMDISSTEIRRSRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXC7</accession>
    <name>A0A068TXC7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00032569001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXC7"/>
    <dbReference type="STRING" id="49390.A0A068TXC7"/>
    <dbReference type="Gramene" id="CDP00584">
        <property type="protein sequence ID" value="CDP00584"/>
        <property type="gene ID" value="GSCOC_T00032569001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXC7"/>
    <dbReference type="OMA" id="WHEKIPS"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXC7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd09247">
        <property type="entry name" value="BRO1_Alix_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF20">
        <property type="entry name" value="ENDOSOMAL TARGETING BRO1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="43158" checksum="F6B0FCDBB5B822B6" modified="2014-10-01" version="1">MMISCPGLSKFKTKQVVFEEVFPACDSGTLEQLKEMSSKRRAIEESINESSSVTEAIAREMSGGLTLRCERDIQKLEQYLPLLENLVYHVNRGRNNPWVDRWMSDLKLRWTSPLISSSIFHVKSPKYFQINYVQFELGMVLFLYGSLLREKALEILQTDLVQSAALFRKAAGVYQHLAHEVLPSLQLAARTERPPESVPSVSSVMSLVCLAEAQAVAARRAEEKGNTQNLLAKLHYGVTDFLDEALVILHSATKECKDISSRFADFIISCRMLHELKSYKYIAESLKVDGKIGAAAGLLRHALTSIGKSTPKGEAWRLVYKQLVQEMTELLRKYEHENDFVWHEKVITKHELPLPETIKIVTSTPYQPQRSEKTLAFKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXE4</accession>
    <name>A0A068TXE4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032589001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="349" mass="38999" checksum="F3F7E82178386874" modified="2014-10-01" version="1">MLTTGTFLCKPFNSRPTSWAPSSVNHVAAANTKKRQSDTNFDKFKTKEIKGWFKFGITSTGLYLSSGARRRRNSTPITTTAGVGGDSSVTEFDDNIRKLLQAVLWVAEGVYILWLFLLPYAPGDPVWAISSETVNSLVGLSLNFFFILPLLNAVGVHTLEAPVLHPMSEGLFNFVIGWTLMFAPLLYTDWRRDRYGGSLDVLWGFQMFLTNTFLIPYMAIRLNKIGTEYNPRKTSQLGSIMTKGAPVVGLIGAAVCLLSTVWALYGRGDGSFGSVPERLEFLMSYLGSERLAYAFVWDICFYVIFQPWLIGDNLQNVQKDNVAVVRYLRYIPVVGLVAYCLCLIPDQET</sequence>
</entry>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY24</accession>
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            <taxon>eudicotyledons</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY24"/>
    <dbReference type="FunCoup" id="A0A068TY24">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00233">
        <property type="protein sequence ID" value="CDP00233"/>
        <property type="gene ID" value="GSCOC_T00032115001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY24"/>
    <dbReference type="OMA" id="MKWREGN"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY24"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000024">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF40">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP00233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="46488" checksum="B89B3AD355A70ABB" modified="2014-10-01" version="1">MSPKTKKNPEKTHQENMVLLPFHFNSWVRSVSVLLVFLMIFHTPLKMSSAIRSFPNNGGWPTETEFGFTEAPEYRNGVECPVTSDETLTFCNPSLVHVAMTLDLEYLRGSMAAVHSVLRHASCPEHVFFHFVAAEFDPASPRVLTRIVRSVFPSLNFKVYIFREDSVVNLISSSIRSALENPLNYARNYLGDMIDPCVKRVIYLDSDVVVVDDVKKLWDVQLSESRVIGAPEYCHANFTKYFTDYFWSDPVLSRIFGSKNPCYFNTGVMVMDLVKWRGGNYRRKIENWMEVQKKKRIYELGSLPPFLLVFGGNVEPIDHRWNQHGLGGDNVKGSCRPLHPGPVSLLHWSGKGKPWARLDEKKPCPLDYLWEPHDLYKPNQQRRVKLHQQLQQGMNSIGYSNYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY41</accession>
    <name>A0A068TY41_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032141001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY41"/>
    <dbReference type="Gramene" id="CDP00258">
        <property type="protein sequence ID" value="CDP00258"/>
        <property type="gene ID" value="GSCOC_T00032141001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="193" mass="21730" checksum="7B77D24AC4DB0D01" modified="2014-10-01" version="1">MFSWYLAIQKLLLYSDNLYAHSMFTITCLFLLLCSWLGFNDKLSQPIASQISKHNHNVHGTIGCNQAHSWNEVSCSHFTKHFIGASKAGIRISPSSNNNTQLSCAELGKKLKQPISSFSSYEKGSTSNSVTQHTCVAIDMIQNADKSFICMNCYKFLTEIAEETSDLSAILPTYEVYEVPHNRSSRRRRNAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY65</accession>
    <name>A0A068TY65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00034792001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY65"/>
    <dbReference type="STRING" id="49390.A0A068TY65"/>
    <dbReference type="Gramene" id="CDP01220">
        <property type="protein sequence ID" value="CDP01220"/>
        <property type="gene ID" value="GSCOC_T00034792001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY65"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF105">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="405"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="544" mass="59630" checksum="C43064023CD429EC" modified="2014-10-01" version="1">MGLFLELLLTAFVAFVFSFVIAKLVSVAVPSSSEEKNLDRKVGAEEVKVDKGLKVGRAKSKKRRVKFVDDVVVGNVVHLESSEEPVKNFHTSESISEKKLVEERAHENMTRDAKDGDVEGKKGSEDVQLLDEAIDGEAVEGKKGVATFGELCSEKNEEVVGSGFRDVSVGEEMKTEGIGGEDGLKLMSDGSDQNDVVEGKKASKDVELLDEAFHREAVGEKNEHAKFGDLCSVKNEVVVGSGLGGVVIGEEIKTESTGDENELKLMTYESNQNDVAAGEKLAANAEYLNKELDREAVYERGKHTAIDADKVYDSNTQMVSGNLDDLVVSVKVKSEVKLAYDDISLPQNEEGRVVSTKEGNAIGIVEDLSKENEGVEDKYILRDEKIDHSAASDDDDWEGIERSELEKVFAEAVNYVEYGAKRKDEQLVSLGSDVLVQLYALHKLALEGPCHDPQPMALMFSARAKWNAWQQLGNMRPEVAMEEYIKILSDNDPGWMQHSSAEDEQHGSLKSETGVCGNPDTESSSVQDPQISFEVGKTKNEKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYS4</accession>
    <name>A0A068TYS4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NPH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00036507001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYS4"/>
    <dbReference type="FunCoup" id="A0A068TYS4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYS4"/>
    <dbReference type="Gramene" id="CDP01455">
        <property type="protein sequence ID" value="CDP01455"/>
        <property type="gene ID" value="GSCOC_T00036507001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYS4"/>
    <dbReference type="OMA" id="RRNDSQW"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYS4"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043454">
        <property type="entry name" value="NPH3/RPT2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027356">
        <property type="entry name" value="NPH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32370">
        <property type="entry name" value="OS12G0117600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03000">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51649">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="NPH3" evidence="7">
        <location>
            <begin position="214"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP01455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="70997" checksum="060805120F768F25" modified="2014-10-01" version="1">MMKSVQMEQQQSSSSDSDGIDQARGHSIIVPGNLIATTYGFEKKEHSWFALSPIPSDLSIQVEDITFCVHKYPLVARCGYLNRLELEPSNPDLGYDPKLENFPGGSETFELVLKFCYDLPIGLNPNNVAALRCASEFLEMTESLEDGNLISKTEAFFTFVVLSSWRDSVTVLKSCEKLSPWAENLQIVRRCCDSISWKVSRENSATVENISEEDWWFEDVVTLRIDHFIRIIVAIRAKGTKPESIGSCIMRYAEKWLPDIDAGKAIKRHGYSQNEVQWSVTTGKSLEGVIGQNKEHRMIIESLVSILPPQKEAVSCKFLLWILKMALVFSISPALISELEKRVGMVLEKANVNDLLIPTYTVGDQGKMVKMINDRAMHNIDVVQRILEYFLIYEQQQQLLLQQNPRTLTVGKLLDNYLAEVARDPNLSISKFQVLAESLPENARTCDDGLYRAIDTYLKTHTSLSEQDRRRLCKIMNCEKLSIDACMHAAQNDRLPLRTVIQVLFSEQVKMRDIIQGKDNCDDNPGQDGSWLCTKKEVNTLKAELEIVKAKMAELQTDYFELQQEYEKLNNKHKSLSSWTFKWMKIKKPSLAQAKIVEEEADDGQPRSHSGHKTKFHRRVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZK8</accession>
    <name>A0A068TZK8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00034993001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZK8"/>
    <dbReference type="Gramene" id="CDP01379">
        <property type="protein sequence ID" value="CDP01379"/>
        <property type="gene ID" value="GSCOC_T00034993001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZK8"/>
    <dbReference type="OMA" id="ENAWSTA"/>
    <dbReference type="PhylomeDB" id="A0A068TZK8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000030">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF460">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654424" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP01379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54068" checksum="7215F4B49E87C754" modified="2014-10-01" version="1">MANILLILSILFVVISHQCYGSQPLSEFLTEKSFKGAFHADSFNALSLRSESDASAKAFAVHVSPQDGLKEKDKIDRLPGQPDGVDFNQFSGYVKVDCGRVLYYYFVESPQDSSSKPLLMWFAGVPGCSSFGVGAWTEIGPFRVNKDGKTLYRNPYAWNSEANLIFVEAPAGVGFSYSNTSAYYERIGDTLTAYDTYTFLVNWLERFPEYKNRGLFLAGEGYAGHYATQLAQLILRQNKYSNQTTAINLKGIALGNSYIDYESSFYGSLDYAWRHALISDEIYNGVNSNCNLSLVIQSDSCSEYLNLSNNVTEGINPYDIYASLCNSTPGAAPYSYVGPCSTDYVSDYMENPEVQIALHANISTVPYPWKICNDLKNWTDAPRTVLPIITELMEGGIQSFQMMFSGDTDSAIPVTSAKYAVNKLKLSAKTAWYPWYLQNEVGGYVVEYQNLTFVTVRGAGLFVPDHQPARALALFTSFINAQLPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZM5</accession>
    <name>A0A068TZM5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00036434001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZM5"/>
    <dbReference type="FunCoup" id="A0A068TZM5">
        <property type="interactions" value="1694"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZM5"/>
    <dbReference type="Gramene" id="CDP01399">
        <property type="protein sequence ID" value="CDP01399"/>
        <property type="gene ID" value="GSCOC_T00036434001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZM5"/>
    <dbReference type="OMA" id="EMMGSEW"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZM5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="325" mass="36514" checksum="707C3F94151AE3D1" modified="2014-10-01" version="1">MGDQQHPDSSPLIVAPAPIKDPSEIDLEAGPEEQIQCRICLETDGRDFIAPCKCKGTSKFVHRECLDHWRAVKEGFAFAHCTTCKAPYHLRVHVLADRRWRTLKFRFFVTRDILFIFLAVQLVISSLAYLVYLVDSHQEFWLRLAWGFDGELSFYYICGALLFFALLGLSGCVITFYDRRVRNDLAQPCRELCLCCCQPGMCADCHLPGTLCMWTDCTTCFESGASAFSECGCLGGAGEAGLPLLLIMALVVLGLFTVIGIFYSVLVATMVGQRIWQRHYHILAKRMLTKEYVVEDVDGEMTGSDWSPPPLPPEHVQQLKTLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0F0</accession>
    <name>A0A068U0F0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037192001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0F0"/>
    <dbReference type="FunCoup" id="A0A068U0F0">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0F0"/>
    <dbReference type="Gramene" id="CDP01991">
        <property type="protein sequence ID" value="CDP01991"/>
        <property type="gene ID" value="GSCOC_T00037192001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0F0"/>
    <dbReference type="OMA" id="GHERWWK"/>
    <dbReference type="OrthoDB" id="1923043at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0F0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35490">
        <property type="entry name" value="BACTERIOPHAGE N4 ADSORPTION B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35490:SF2">
        <property type="entry name" value="BACTERIOPHAGE N4 ADSORPTION B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="468" mass="52122" checksum="8F31F9455A9A358C" modified="2014-10-01" version="1">MPTFTAIALDRLIETGAPQTMAGGKNGPDVKVEGRNSTSISTFDKGVTAPRSKLEKAVSIPTGKLDTRNDTSNVTIDGKRHWAQISPALYATPEPTPLPDSPSSFPPSPYIINHKRRGPRLLKSFSQDDVGTRHQALDEKKLDDEVKHAEREVASSTHDNNTLRDKVIESPEVYDGASTVHSPVEEKSVNGISNGELGINDLANHSVVENSISISAIFSFQRDGEGDDFFDPQESMSVKSNAESETNSVVERSLNVATPLAEFYDAWEELSSETGPQPSVPDFEAELRELRLSVLTELERRRQAEESLRNTRAQWQKIREELSVIGLTLPVDLVAALEDINPIRELSQQFDLARFVSNSIGRGTAKAEVEMEMEALMELKNFEIARLLDRLHYYEAVNREMSQRNQETIEISRRLRQRRKKRQRWIWGSVAAAITVGAAVLAWSCFPTGKGSSTNLLRSPESDHTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1G8</accession>
    <name>A0A068U1G8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00039718001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1G8"/>
    <dbReference type="FunCoup" id="A0A068U1G8">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1G8"/>
    <dbReference type="Gramene" id="CDP02356">
        <property type="protein sequence ID" value="CDP02356"/>
        <property type="gene ID" value="GSCOC_T00039718001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1G8"/>
    <dbReference type="OMA" id="CESEMTY"/>
    <dbReference type="OrthoDB" id="495795at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1G8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34276">
        <property type="entry name" value="MINI-RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34276:SF1">
        <property type="entry name" value="MINI-RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="248" mass="27612" checksum="57DF7CB3CF46F8B9" modified="2014-10-01" version="1">MAAALPRLSLSGTLLVHPNRKIPTAALTTSSVDTKQRLPYNPHRTYPAKPQKPQLDLTPTLSTSSISVSDLLKRATPAPSSTTAKGTLCESEMTYLGYERWLPSPPKVEKPRSVFNAASLAYIGDCIYELYARRHFLVPPLNIEEYNDRVTAVVRCEAQDAMLQKLINDDFLSEQERDVLRWGKNVGSSKTRTKKRAGVAVYNRASSLETLVGYLYLTNVERLEEIMLMLGFCSGASDQSIPKEEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U513</accession>
    <name>A0A068U513_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00016085001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U513"/>
    <dbReference type="FunCoup" id="A0A068U513">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U513"/>
    <dbReference type="Gramene" id="CDP03650">
        <property type="protein sequence ID" value="CDP03650"/>
        <property type="gene ID" value="GSCOC_T00016085001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U513"/>
    <dbReference type="OMA" id="FVERRWS"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U513"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd22152">
        <property type="entry name" value="F-box_AtAFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF21">
        <property type="entry name" value="F-BOX_KELCH-REPEAT PROTEIN SKIP30 ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="347" mass="38225" checksum="3C54C3F12EBDEFBF" modified="2014-10-01" version="1">MSGLIEGLPDAVALRCLARVPFYLHPRLELVSRSWRAAIRSTELFKAREEVNSTEEFLCVCAFEPDNLWQLYDPLHDIWITLPVLPSNIRHLAHFGVVSTAGKLFVLGGGSDAVDPLTGDQDGSFATDEVWSYNPVTRHWALCASMIVPRAMFACGVLDGKIVVAGGFTSCRKSISKAEIYDPEKDVWASIPDLHHTHNSACSGVVIGGKVHVLHKGLATVQVLESAKQGWTVHEYGWLQGPMTVVKGKLYVMSHGHGLIYKQEGESRKIVVSASEFRRRIGLAMIGVAGDIYVIGGVIGPERWNWDIKLMSDVDVLTLGGDRPVWRQVAPMTRCRGTILGCTQLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5D8</accession>
    <name>A0A068U5D8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00041972001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the 19S regulatory particle (RP/PA700) base subcomplex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The RP/PA700 complex is composed of at least 17 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5D8"/>
    <dbReference type="FunCoup" id="A0A068U5D8">
        <property type="interactions" value="3190"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5D8"/>
    <dbReference type="Gramene" id="CDP03399">
        <property type="protein sequence ID" value="CDP03399"/>
        <property type="gene ID" value="GSCOC_T00041972001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5D8"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5D8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="195"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP03399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="420" mass="47440" checksum="D26AFC99C724C598" modified="2014-10-01" version="1">MATAEVEKNRSGAEREESCSSKGTMMVKQGEGLRQYYLQHIHDLQLQVRQKSHNLNRLEAQRNELNSKVRMLKEELQLLQEPGSYVGEVVKVMGKSKVLVKVHPEGKYVVDIDKNIDITKITPSTRVALRNDSYVLHLILPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSARMESGSGNGDSEVQRTMLELLNQLDGFEASNKIKVLMATNRIDILDQALLRPGRIDRKIEFPNPNEESRFDILKIHSRKMNLMRGIDLKKIAEKMNGASGAELKAVCTEAGMFALRERRVHVTQEDFEMAVAKVMKKETEKNMSLRKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5I8</accession>
    <name>A0A068U5I8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016301001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5I8"/>
    <dbReference type="FunCoup" id="A0A068U5I8">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5I8"/>
    <dbReference type="Gramene" id="CDP03815">
        <property type="protein sequence ID" value="CDP03815"/>
        <property type="gene ID" value="GSCOC_T00016301001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5I8"/>
    <dbReference type="OMA" id="CWIAEEH"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5I8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="77"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP03815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="273" mass="28759" checksum="A4FF6B22C9472642" modified="2014-10-01" version="1">MASPSLHSLPGGLTDATKSLLYSCSNLLPTPPHSSPPRSNSSHITRSPRKTMSTSAQASSSLPPLPEDRIVLGCGLVSADFLATVAFYPNPDDKTRSTSAKLQGGGNAGNSLTCAARLGLKPRLISKVADDPQGKGLIEELEADGVDTSFLVVSEGGNSPFTYVIVDNQTKTRTCIHTPGCPPMIPDDLSTSNLLAAISGARLVYFDGRLHETALLVAQEANRRAIPILTDAESKSEGLDDLLSLSSYVVCSAKFPQARVICKYLTSFLAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U681</accession>
    <name>A0A068U681_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450 714C2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00016548001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U681"/>
    <dbReference type="STRING" id="49390.A0A068U681"/>
    <dbReference type="Gramene" id="CDP04021">
        <property type="protein sequence ID" value="CDP04021"/>
        <property type="gene ID" value="GSCOC_T00016548001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U681"/>
    <dbReference type="OMA" id="RISYMEL"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U681"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF196">
        <property type="entry name" value="CYTOCHROME P450 714C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39238" checksum="8F30A14DA8EBBED6" modified="2014-10-01" version="1">MTICMIYREWLVGLVQESTVTMVNSWKSIIEAGGGIADIKIDQHMRSFSGDVISRACFGSNYSKGEEIFKRLRALQEAASKRVLATGIPGARHLPTKSNREAWALEKEIKTLILQVVKERTEAGYEKDLLQMVLEGAKSSDLSRDDIDRFIVDNCKNIYLAGYETTAVSATWCLMLLAANPDWQERIRAEAVEICRGQIPDADMIRKMKQLTMAINESLRLYPPVSVVSREALKDMKFGDIKIPQGVNVWTLVTTLHTDPEIWGPDSYKFNPDRFANGITGACKLPHLYVPFGVGPRVCLGQNLALVELKILISMILANFSFSISPRYKHSPALHLVIEPGNGVDLLVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7A9</accession>
    <name>A0A068U7A9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00015313001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7A9"/>
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    <dbReference type="STRING" id="49390.A0A068U7A9"/>
    <dbReference type="Gramene" id="CDP03498">
        <property type="protein sequence ID" value="CDP03498"/>
        <property type="gene ID" value="GSCOC_T00015313001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7A9"/>
    <dbReference type="OMA" id="DIAICVC"/>
    <dbReference type="OrthoDB" id="2422440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7A9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
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    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55026" checksum="FF86D539E21A62A1" modified="2014-10-01" version="1">MEHLVKLPEGLPSFSHIYHNDFVGRKPKKMKDDDVAICFCKYDPNNPESACGEGCLNVMTSTECTPGHCPCQDHCKNQRFQNCEYAKTKLFQTEGRGWGLLADEDIKAGQFIIEYCGEVISLEEAKHRSQSYEAQGLKDAYIISLNSNYFIDATKKGSLARFINHSCLPNCETRKWTVLGETRVGIFAKVDISSGTELSYNYNFEWYGGATVRCLCGAANCCLFLGAKSPGFQAYNHVWEEGDDRYRVEEVPLYDSAEDEPFPRIPETISPFKFESLDGLEADYSQKLEVGDVFGQELDSSNTVKLHNSVQVGGTTTNTEKAEVLESGKSKEEDMQQAFYQTSAVLSGLRSNTASQNFNVGSGSSPKKRSQRLPKQKKRSTGGKQSNTKNIAALFPSKEAQEEVRKYEEMKNQAAANLKSVYDEIRPAIEKHERDGQDNVPPSVGTKWVGAHCAKYKADLNFSASVIKNFLDIAQKGGSGSKAGTGPKASGSGDPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7B7</accession>
    <name>A0A068U7B7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00017778001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="Bharathi K."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA96"/>
    <dbReference type="STRING" id="49390.A0A068UA96"/>
    <dbReference type="Gramene" id="CDP05119">
        <property type="protein sequence ID" value="CDP05119"/>
        <property type="gene ID" value="GSCOC_T00020059001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA96"/>
    <dbReference type="OMA" id="KMYLVNA"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UA96"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47198">
        <property type="entry name" value="OS05G0299300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47198:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="5">
        <location>
            <begin position="54"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="461"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP05119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="631" mass="70649" checksum="80966EAF8C58853F" modified="2014-10-01" version="1">MENMLYAEELVREFLVFRGFTTTLQSFEKELATDVGKGFQVEKILDLVFSIYIPKFQAESLVDLLSFFKQCFSSSETAHIEALLKLHVSILRYYIVYAIQSRRKDKVVEFFDAHGTNLLQNNQEWASWFAIPYLKNPHLEPQFRMYFTKEWYNALHLSVRNFLSKMFNALLKISSERITVNRLKKDIKQLNLKLSELQALLEEKEAQLSQSRSNALVQAEVGILATNSSSKFAAANAEENSISRRVKSTSDLGKINSIQDQSGDMPAEDFHSTSRVDSHLSGSERSHDLIAAQETDGEMHRDEDFPEVKVEFQERFLGHTSPISRCRFSASGDNIASASVDGTVRIWTYDSSAPASRNATIYCGAEVLSLEWDCKSDRLLLIGTADGCIKAWNVDAKRVVCDLNSNREFPSVLDIKCSPVEPIFVSASASRGHGTNYIDKLGFASLTVWNMRSWKAMTVLPLGKDPPAITSVCFNHNGKLLAAAATDGMIHMFDMSAGLQITGWPAHDSAISSVHFGPDETSIFSLGADGKIFEWSLHNQGKILWSRNCSRFCNFENSLHCRHEMALDANGKRLLLTSNSVRAPIYQVRDCTTGMRTLPHSACVTTVDWHPTLPIFLTGSADNSVRVTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAB4</accession>
    <name>A0A068UAB4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxalate--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acyl-activating enzyme 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Oxalyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00020155001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAB4"/>
    <dbReference type="FunCoup" id="A0A068UAB4">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAB4"/>
    <dbReference type="Gramene" id="CDP05192">
        <property type="protein sequence ID" value="CDP05192"/>
        <property type="gene ID" value="GSCOC_T00020155001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAB4"/>
    <dbReference type="OMA" id="TFRGYYR"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAB4"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050203">
        <property type="term" value="F:oxalate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010030">
        <property type="term" value="P:positive regulation of seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010214">
        <property type="term" value="P:seed coat development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000039">
        <property type="entry name" value="Peroxisomal-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="12">
        <location>
            <begin position="430"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP05192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="529" mass="56678" checksum="D7B0ED9D955A8CA1" modified="2014-10-01" version="1">MENLTLSGLLIKVAAKFPSRRAISVPGRFDLSHARLHQLVERTATRLVAAGVQPGDVIALTFPNSVEFVIAFLAVIRARATAAPLNPAYTADEFQFYLSDSDSKILLTSKQGSAPAQAAASKLNIPHVTVALPDADSDVALSSSLSQYESDPEPDPNLSSKLINDPSDISLFLHTSGTTSRPKGVPLTQLNLVSSVNNIKSVYRITESDSTVIVLPLFHVHGLLAGLLSSVGAGGAVTLPAAGRFSASTFWSDMKNYNATWYTAVPTIHQIILDRHLNSPEPVYPRLRFIRSCSAALAPSILARLEEAFGAPVLEAYAMTEASHLMASNPLPQDGPHVPGSVGKPVGQEMAILDENGKPQEANANGEVCIRGPNVTKGYKNNPEANKSAFQFGWFHTGDLGYLDSDGYLHLVGRIKELINRGGEKISPIEVDAVLLSHPDVAQAVAFGVPDDKYGEEINCAVIPREGANIDESEVSRHCKTNLAGFKVPKKVFITDSLPKTASGKIQRRIVAEHFLAQISTAKVPKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAL3</accession>
    <name>A0A068UAL3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00020749001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAL3"/>
    <dbReference type="FunCoup" id="A0A068UAL3">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05605">
        <property type="protein sequence ID" value="CDP05605"/>
        <property type="gene ID" value="GSCOC_T00020749001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAL3"/>
    <dbReference type="OMA" id="DIMHAMN"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAL3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900994">
        <property type="term" value="P:(-)-secologanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000040">
        <property type="entry name" value="UDP-glycosyltransferase 76C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000120">
        <property type="entry name" value="UDP-glycosyltransferase 76C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1464">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 76B1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50789" checksum="B12964190983F016" modified="2014-10-01" version="1">MQAKKGRHRLVLFPVPLQGHINPMIHLASILHLKGFSISIIHTQFNSPDHSKYPNFAFHSIPDGLLEHQFSTSDLAALVTRLNLNCIRPFRECLASLLSDNEEHVASLITDSIWHFTQDVADSFKLPRIVFRTTSVCSFLAFHALPHFREKGYLPKQDSQLEARVGEFPPLKVKDIPVIKTRFPESLDRIISLMMEGTKAASGLIFNTFKELEDNELMKIGQEFCIPIFAVGPLHKYFPASSSSLLRQDQSAIIWLDKQAPKSVIYVSFGSIAEMDETQLSEVAWGLANSRQPFLWVIRPGLVQNSEELARLPNGFLDAVEGRGYIVEWAPQQEVLAHPAIGGFWTHSGWNSTLESICEGVPMICSPFFGDQMVNSRFVNDVWKLGLQLEKGLDREEIEMLIRRLMTEKEGEEIRDRVMSLKDTINSCLEQGGSSNQSLESFIDYILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAU4</accession>
    <name>A0A068UAU4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein EXORDIUM-like 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00020306001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EXORDIUM family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAU4"/>
    <dbReference type="FunCoup" id="A0A068UAU4">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAU4"/>
    <dbReference type="Gramene" id="CDP05309">
        <property type="protein sequence ID" value="CDP05309"/>
        <property type="gene ID" value="GSCOC_T00020306001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAU4"/>
    <dbReference type="OMA" id="ITIHTIW"/>
    <dbReference type="OrthoDB" id="2016249at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006766">
        <property type="entry name" value="EXORDIUM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279:SF7">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04674">
        <property type="entry name" value="Phi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654705" description="Protein EXORDIUM-like 3" evidence="6">
        <location>
            <begin position="32"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38058" checksum="71D5F133808E7495" modified="2014-10-01" version="1">MGSPPAPVTLLFTILLPLFVSFLAGAPLALGWRPWPNQDKPNATDFIYGASKKYEGSSDFVHLKYHMGPVLTANITVYPIWYGVWQNSQKRIIREFITSFSAFNSKPPSVSGWWKTVQLYTDQTGANISSHVHLGEEKNDRFYSHGKSLTRLSVQSVIKSSVTARTKPLPINPKSGVYLLLTSEDVYVQDFCNNVCGFHYFTFPSILGYTLPYAWVGNSAKLCPGVCAYPFSVPDYIPGLKAVKAPNGDVGVDGMISVIGHEIAELSTNPLVNAWYAGQDPVFPVEIADLCEGIYGTGGGGSYTGQMSNGEDGATYNMNGIRRRFLLQWVWNPLLNYCTGPNALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB17</accession>
    <name>A0A068UB17_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Auxin response factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00020853001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB17"/>
    <dbReference type="FunCoup" id="A0A068UB17">
        <property type="interactions" value="1122"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB17"/>
    <dbReference type="Gramene" id="CDP05666">
        <property type="protein sequence ID" value="CDP05666"/>
        <property type="gene ID" value="GSCOC_T00020853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB17"/>
    <dbReference type="OMA" id="CESTNVP"/>
    <dbReference type="OrthoDB" id="2016915at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009835">
        <property type="term" value="P:fruit ripening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000047">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF150">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0292">Fruit ripening</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="12">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="13">
        <location>
            <begin position="773"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP05666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="906" mass="100062" checksum="3FF4A1CF7BC207EF" modified="2014-10-01" version="1">MRLSPAGFTQQPPEGERRCLNSELWHACAGPLVSLPAIGSRVVYFPQGHSEQVAASTNKEVDAHIPNYPSLPPQLICQLHNVTMHADVETDEVYAQMTLQPLSPQEQKEASYLPADLGSPSKQPTNYFCKTLTASDTSTHGGFSVPRRAAEKVFPPLDFSQQPPAQELIARDLHDNEWKFRHIFRGQPKRHLLTTGWSVFVSAKRLVAGDSVLFIWNEKNQLLLGIRRANRPQTVMPSSVLSSDSMHLGLLAAAAHAAATNSRFTIFYNPRASPSEFVIPLAKYVKAVYHTRVSVGMRFRMLFETEESSVRRYMGTITGISDLDPVRWPNSYWRSVKVGWDESTAGERQPRVSLWEIEPLTTFPMYPSPFPLRLKRPWPLGLPSFNGMKDDEMGINSPLMWFRGDVGERALHCLNYQGIGVAPWMQPRVDAPILGMQTDLYQAMAAAALQEMRAVGPSKQALSSLLQFHQTQGIANRPTSLVQPQTLQQSQPEPTFLQGLPGSQSPAQSQTQAPSLLIQQQLHHQNSFSNLQQRQQQQQPLPQQQQQVNDHQQVSSVATVLPQLTSSSQVQSHSIQAISPMHQQSFSDSNGNSVTSSILSPLQSLLGSVPQDEASHLLSVPRSSSLLSPSGWPPKRVAIDPILPLGVSQCISPLMEEMGPPNNSISQNSVSLPPFPGRECSIDQEGTNDPQNSLLFGVNIDSSSLLIQNGMSNLRGVVSDGGCTTIPFPSSNYAGTTGTKFQQNPEMTPSSCIQESGFLRSPDNIGQGNPATRTFVKVYKSGSFGRSLDISKFSSYHELRIELARLFGLEGLLEDPLRSGWQLVFVDRENDVLLLGDDPWPEFVNSVWCIKILSPQEVQHMGKRGLELLNSAPNSRLPNGSCDDYASLQEPRNAITRMTSVGSLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBF3</accession>
    <name>A0A068UBF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00019857001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBF3"/>
    <dbReference type="FunCoup" id="A0A068UBF3">
        <property type="interactions" value="3019"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBF3"/>
    <dbReference type="Gramene" id="CDP04973">
        <property type="protein sequence ID" value="CDP04973"/>
        <property type="gene ID" value="GSCOC_T00019857001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBF3"/>
    <dbReference type="OMA" id="AMNMQLK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="91"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="435" mass="47625" checksum="F92F88E319CFD985" modified="2014-10-01" version="1">MNIARSCSRSVNQLRPLKNLTLLLQSPAIATTRAISTVPPAILNRSSLLSNHLSPRQLSPLPPALSVASVRHFRNSRDPATRFEISPPVNWGIRIVPERKAFVVERFGKYVKTLTPGIHFLIPFVDRIAYVHSLKEEAIPVPDQSAITKDNVSILIDGVLYVKIVDPKLASYGVENPIYSVLQLAQTTMRSELGKITLDKTFEERDALNEKIVIAINEAAKDWGLKCLRYEIRDISPPRGVRAAMEMQAEAERKKRAQILESEGERQANINIADGRKSSVILASEGAKVSMILASEGEAEAILARAKATAEGIAMVSRSLKEHGGVEAASLRVAEQYIQAFGNIAKEGTTLLLPASASNPANMVAQVMSIYKNLVKKSPADELPEISESVALPESSPKESSLPEPRRKEKDENSQAAENHSGESAFSLQDTKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBX1</accession>
    <name>A0A068UBX1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00021336001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBX1"/>
    <dbReference type="FunCoup" id="A0A068UBX1">
        <property type="interactions" value="1024"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBX1"/>
    <dbReference type="Gramene" id="CDP05996">
        <property type="protein sequence ID" value="CDP05996"/>
        <property type="gene ID" value="GSCOC_T00021336001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBX1"/>
    <dbReference type="OMA" id="FPAMCSK"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBX1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000015">
        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="209"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="390" mass="41379" checksum="DA76A5E723A47A05" modified="2014-10-01" version="1">MASVLVPIANGTEPVEAVVPIDVLRRAGAEVTVASVEKKLQIDACRGVKIVADALISDCADNVFDLISLPGGMPGATTLKDNKTLESIVKKQASEGRLYAAICASPAVALGSWGLLKGKKATCYPSFREQLSAAAAIVSDSIVEHDGNVVTSQGPGTAMEYAVALVEQLFGKEKAKEVSGPLVMRTIHGAEFLFAEFNRVNWTCDGSPKILVPIANGTEEMEALIIIDVLRWVNAEVLVASVEDKLEVVASRKVKLVADVLLDDVVNGSYDVIVLPGGLGGAQAFAKSGNLVNLLKKQRESNRPYGAFCASPALVLEPHGLLKGKKATAFPALCDKLTDPSEAENRVVVDGHLITSRAPGTSLEFAFAITEKLFGREKALELAKFLVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCL7</accession>
    <name>A0A068UCL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023048001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCL7"/>
    <dbReference type="STRING" id="49390.A0A068UCL7"/>
    <dbReference type="Gramene" id="CDP06290">
        <property type="protein sequence ID" value="CDP06290"/>
        <property type="gene ID" value="GSCOC_T00023048001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCL7"/>
    <dbReference type="OMA" id="AYFTSSH"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048262">
        <property type="term" value="P:determination of dorsal/ventral asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000154">
        <property type="entry name" value="Transcription factor SRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044636">
        <property type="entry name" value="RADIALIS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43952">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43952:SF75">
        <property type="entry name" value="PROTEIN RADIALIS-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10224" checksum="7F1413D282636643" modified="2014-10-01" version="1">MASNSTWTYQQNKLFENALATYCEDPPELFFQNVAKAVGDKTAEEVKRHYEILVEDIQKIESGQIPLPNYNDDVDIKDEKQVTDEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE30</accession>
    <name>A0A068UE30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KIB1-4 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021207001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE30"/>
    <dbReference type="FunCoup" id="A0A068UE30">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UE30"/>
    <dbReference type="Gramene" id="CDP05893">
        <property type="protein sequence ID" value="CDP05893"/>
        <property type="gene ID" value="GSCOC_T00021207001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE30"/>
    <dbReference type="OMA" id="EPPISSW"/>
    <dbReference type="OrthoDB" id="642536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050942">
        <property type="entry name" value="F-box_BR-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259:SF114">
        <property type="entry name" value="OS06G0707300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259">
        <property type="entry name" value="OS07G0183000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIB1-4 beta-propeller" evidence="1">
        <location>
            <begin position="65"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="401" mass="45306" checksum="D028CD5366F4E703" modified="2014-10-01" version="1">MADWANLMPELLAQVAQRLAGHDFIVFRAVCKPWQFASLTLKEKPPLPPWLDEDGLKDAPKIRRFFNLSTLKAYEFELPEASGRNCVGASYGCIFTLGHDLQISLVHPFTRKQISLPSMLAFSDHYAYHHEYRPQELFSMFVEKVALSSNPWLDEKTGLHDDHTHQDCCVIAAIYGEVSILAFARLGDEVWTNIRVPSKAYEDIIFHQDKLYAVDCHGSVVACDIDDDKSGGDGPRAKIIAPIPYEPPDYTQKYLVESSGDLLLVARTRGGEETEDGEVLNYYTIGFSVLKLEDRLGCHDHLEENIDDNEYPYKWTEVSGLGDRALFLGRNPSASLPAYKYNGSLKPNCIYFTDDDPDNFWGDRDGGGLDMGIFNLENGTIEPHFPGKSIHPEFPPFWLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEK2</accession>
    <name>A0A068UEK2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023961001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEK2"/>
    <dbReference type="STRING" id="49390.A0A068UEK2"/>
    <dbReference type="Gramene" id="CDP06916">
        <property type="protein sequence ID" value="CDP06916"/>
        <property type="gene ID" value="GSCOC_T00023961001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEK2"/>
    <dbReference type="OMA" id="PWIINNQ"/>
    <dbReference type="OrthoDB" id="735686at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF29">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="220" mass="25550" checksum="468AB36433136C2F" modified="2014-10-01" version="1">MMVNNLLLQLLCNIDKQNILIPICHPLSREPNKLFTGGRSIIQMSYEKLEELDIRESTPVICRTERIMLLQHWANNKSVQEALHVLRETIGQWVSCRDALPYTKNAGSVVPYHANLSTKGYRSLIYSGDHDLMVPHIETQAWIRSLHYPIIDDWRQWIHEGQVAGYTRTYANEMTFATVKARNSRFYCFSARFGGGHAAYEFKPAECRTMLERWISHQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEL8</accession>
    <name>A0A068UEL8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">persulfide dioxygenase</fullName>
            <ecNumber evidence="12">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00021437001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="12"/>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEL8"/>
    <dbReference type="FunCoup" id="A0A068UEL8">
        <property type="interactions" value="1495"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEL8"/>
    <dbReference type="Gramene" id="CDP06078">
        <property type="protein sequence ID" value="CDP06078"/>
        <property type="gene ID" value="GSCOC_T00021437001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEL8"/>
    <dbReference type="OMA" id="VMDIDYA"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEL8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009960">
        <property type="term" value="P:endosperm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP06078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="256" mass="27822" checksum="13AB7A40C9898A71" modified="2014-10-01" version="1">MGSYTTASESQLSGSKKLLFRQLFEKDSSTYTYLLADASHPDKPALLVDPVDKTAERDLSLVKELGLKLIYAINTHVHADHVTSTGLIKSKVPGVKSIISKASNAQADLLIEPGDKVYFGDLFLEVHATPGHTLGCVTYVTGDGPDQPQPRMAFTGDALLIRGCGRTDFQGGSSETLYKSIFTLPKDTLVYPAHDYKGFTVSTVGEEMKYNPRLTKDEAGFKGIMENLNLPYPKMMDVAVPANVLCGLQDVESKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG26</accession>
    <name>A0A068UG26_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00024360001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068UG26"/>
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        <property type="protein sequence ID" value="CDP07192"/>
        <property type="gene ID" value="GSCOC_T00024360001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG26"/>
    <dbReference type="OMA" id="CYADCSE"/>
    <dbReference type="OrthoDB" id="1886586at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG26"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000211">
        <property type="entry name" value="Polyubiquitin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="227" mass="25249" checksum="D01E73574B4808C0" modified="2014-10-01" version="1">MQIFVKTPTGKAITLEVDSSDTIDNVKAKIQDEEGFPLDVQRLIFAGKQLKDGWTLADYYIQEESTLHLVPRLWGGGGMEISVKTRTGKPLTLVVMSSDTIKDVKAKILSKEGIPPKKQRLVFAGTPLEDGRTLADYEIPSKSTLKLVLSTHEMGPETLIDPITNKINWTNLKTCNIQVFCFSLYKIRASLTFISHSLIYPSSSSSIFSQILPSKDADLRERSDSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG87</accession>
    <name>A0A068UG87_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024506001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG87"/>
    <dbReference type="STRING" id="49390.A0A068UG87"/>
    <dbReference type="Gramene" id="CDP07282">
        <property type="protein sequence ID" value="CDP07282"/>
        <property type="gene ID" value="GSCOC_T00024506001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG87"/>
    <dbReference type="OMA" id="TNEAFFM"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG87"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044821">
        <property type="entry name" value="At1g28695/At4g15970-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46038">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46038:SF13">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="363" mass="42252" checksum="74E7A520909CA37B" modified="2014-10-01" version="1">MVSNLPPKLSIYVIGSTYDKLVLWVLLFEDLVWIYEELYELNRVLQKAATMNRTVIMTTLNEAWAAKDSIFDLFIESFKIGNQTEGLLKHLLVIALDQKAYARCLKSKLHCYSLRTDGIDFSGEAYFMSADYLKMMWRRVQFLTKVLDMGYNFLFSDADIMWFRDPFPHFYPDADFQIACDYFRGNPSDIENAPNGGFTYVKSNNKTRQFYRFWHDSRILYPKYHDQDVLNKIKRDPCIQQMGLKIKFFDTAYIGGFCEPSRDLNKVCTMHANCCAGLENKVHDLKIMLEDWRKYMKLSESNRSDHSWTVPQLCGYALPNYSGIRLISLKGGVANFFFSFFVIICSLASFGRHRSTNKTSEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGQ8</accession>
    <name>A0A068UGQ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iron hydrogenase small subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024738001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGQ8"/>
    <dbReference type="FunCoup" id="A0A068UGQ8">
        <property type="interactions" value="2341"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGQ8"/>
    <dbReference type="Gramene" id="CDP07467">
        <property type="protein sequence ID" value="CDP07467"/>
        <property type="gene ID" value="GSCOC_T00024738001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGQ8"/>
    <dbReference type="OMA" id="VMPCTCK"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGQ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase small subunit" evidence="2">
        <location>
            <begin position="482"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="549" mass="60863" checksum="18837F8D8A354961" modified="2014-10-01" version="1">MSSEKFSATLSIGDLNDYIAPSQGCVVSFKANSNSNPKPSTSSCSSRLDKSYAGNSAKLGSAIKPLETEPVKISLNDCLACSGCITSSKTVMLEKKSLDEFLSNINKGKAVIVSVSPQSRASLGVAFGLSPLQASLFSYVFKKLTTLFKALGVKAVFDTSCSRDLTLIESCYEFITRYRQCHSTTDKKSKLGLPLISSACPAWINYAEKNLGSYILPNISSVKSPQQIIGAIIKNHICQMLYQRPEDIYHVTVMPCYDKKLEAVRDAFVFQLDAQGEKIVEVDSVLTTVELLDLIKVIFDFFKCMVPSPLSPSSITLSKTFLQAFVLLWLFSPGKWVVADVWTFIDMLPEFDFLQSKSVDFASLEELPLDNLLTNLDDGNLLYGVRGSSGGYAETIFRYAAKNLFGKEIVGPLNFKTIRNPNFQEVTLEVEGETVLKFALCYGLQNLIQVVKKIDSGECEYQFLEIMACPSAGCLNGGGQIKRKPGESVQSLELKYMENVIEADPFENPIIKGLYTEWLDQPGSEKATKYMHTEYHPRVKSRTSQLQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHH5</accession>
    <name>A0A068UHH5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">1,3-beta-glucan synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00025008001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHH5"/>
    <dbReference type="Gramene" id="CDP07677">
        <property type="protein sequence ID" value="CDP07677"/>
        <property type="gene ID" value="GSCOC_T00025008001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHH5"/>
    <dbReference type="OMA" id="HISVYKW"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHH5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.270:FF:000002">
        <property type="entry name" value="callose synthase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058851">
        <property type="entry name" value="CALS1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF86">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25968">
        <property type="entry name" value="CALS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="15">
        <location>
            <begin position="315"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP07677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1451" mass="167564" checksum="9BB1A163B2FF8B95" modified="2014-10-01" version="1">MAYQRRGSDLQPQRRILRTQTAGNLGESMMDSEVVPSSLVEIAPILRVANEVEPTNPRVAYLCRFYAFEKAHRLDPTSSGRGVRQFKTALLQRLERENDTTIAGRTKSDAREMQSFYQHYYRKYIQALHAADKADRARLTKAYQTAAVLFEVLKAVNLTEAVEVADEILEAHTKVTEKTAIYVPYNILPLDPDSASQAIMRYPEIQASVSALRNIRGLPWPKGHKKKVDEDILDWLQVMFGFQKHNVSNQREHLILLLANVHIRQFPKPDQQPKLDDEALTEVMKKLFKNYKKWCKYLGRKSSLWLPTIQQEVQQRKLLYMGLYLLIWGEAANLRFMPECLCYIYHHMAFELYGLLAGSVSPTTGETIKPAYGGDEEAFLKKVVTPIYNTIAGEAKRSKDGKSKHAQWRNYDDLNEYFWSENCFRLGWPMRADSDFFCIPGERHRSDKTEESERSTGDRWMGKINFVEIRSFWHIFRSFDRMWSFFILCLQAMIIVAWNGSGDLGSVFEANVFKKVLSIFITAAILKLIQAVVDVIMSWKAWHNMSPHVKLRYVLKVVSAAAWVIVLPVTYAYSWKNTAGIAMTIRNWFGNGASSPSFFIIASLIYLSPNMLSGLLFLFPFIRRYLEKSDYKIFRLIMWWSQPRLFVGRGMQESTFSLFKYTLFWVLLLAAKLAFSFFIEIKPLVNPTKEIMKVHISRYAWHEFFPRANKNIGVVIALWAPIILVYFMDIQIWYAIFSTIFGGIYGAFRRLGEIRTLGMLRSRFQSLPGAFNACLIPVEKGKKPKKGLKATFSRKFDEIPSSKEKEAARFAQMWNKIIESFREEDLINNREMNLLLVPYWADRDLNLIQWPPFLLASKLPIALDMAKDCAGKDRVRELNKRLTADVYMRCAIRECYLSCKSIINSLVVGEREKVVLNEIFSKADEHIEKGDLTVEFQMGALPSLYEQFVQLIEYLKENKKEDKDQVVIVLLNMFEVVTRDIMEDSIPSILDSSHGGSYSMHEAMTPIDKQYQFFGKLRFPVTEETDAWKEKIQRLHLLLTVKESAMDVPSNLDARRRISFFSNSLFMDMPDAPKVRNMLSFSTLTPYYNEEVLFSINSLKKPNEDGVSILFYLQKIYPDEWDNFLERVDCSNEEDLMGNVKLEEELRLWASYRGQTLTKTVRGMMYYRQALELQAFLDMAKDEELLKGYKAVVSNTEEQLRNERSLLVQCQAVADMKFTYVVSCQQYGIQKRSGDPHAADILRLMTKYPSIRVAYIDEVEEPSKDKTKKTVEKVYYSALVKAMPKSVDSSEPDQNLDQVIYRIKLPGPALMGEGKPENQNHAIIFTRGEGLQTIDMNQDNYMEEAFKMRNLLQEFLIKHGVSTPTILGLREYIFTGSVSSLAWFMSNQETSFVTIGQRLLANPLKVRFHYGHPDVFDRLFHLTRGGISKASKTINLSEDIFAGILTSLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHS3</accession>
    <name>A0A068UHS3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00025098001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHS3"/>
    <dbReference type="FunCoup" id="A0A068UHS3">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHS3"/>
    <dbReference type="Gramene" id="CDP07744">
        <property type="protein sequence ID" value="CDP07744"/>
        <property type="gene ID" value="GSCOC_T00025098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHS3"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHS3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF4">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF3-1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40963" checksum="CA079187C087B993" modified="2014-10-01" version="1">MDYYKEKYKKELQEKERSKQRSKVSLRNGGCKEVRFAAKITPNDLQIKADMAKRLMESGYRVKCVAIGNVDKGEDSATLFSRFSALIEDIAVVETDTRVEEKDQAHVIMRHVKYGPLKKGSLKRASMDKKAASASVQEVGGDDDVLSEERDDVEQKEISGWTTANADDDFDELFDLNDNADGVSKSSRSEKFSIAREPSSSSEGGSSHYPRPGGRDTLQSGSQFPDRVRQPPLNMNASPQRRETEGVNRAYPASTNSRNHGQNFAPDNPDPQGPSYGVFRARQGNDAHGKQNAPAEVNRYKQRNAPDSRRNSSPPRAAGHQNGPMSDFKFGREQAVNRDEQGRWGVFSGESTNVIPNRTFDGQAKVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHW1</accession>
    <name>A0A068UHW1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025194001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHW1"/>
    <dbReference type="FunCoup" id="A0A068UHW1">
        <property type="interactions" value="1676"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHW1"/>
    <dbReference type="Gramene" id="CDP07804">
        <property type="protein sequence ID" value="CDP07804"/>
        <property type="gene ID" value="GSCOC_T00025194001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHW1"/>
    <dbReference type="OMA" id="FGATDNW"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHW1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF70">
        <property type="entry name" value="OS05G0316100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP07804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="52355" checksum="93D61462E5BDA189" modified="2014-10-01" version="1">MAAATGLGAVPFFFVELDPQWSGICNGMAAGVMLAASFDLIQEGQDHGSGSWVVLGILAGGIFIWVCKKILEQYEEVSMLDIKGADAAKAILVVGIMTLHSFGEGSGVGVSFAGSKGLSQGILVTLAIAVHNIPEGLAVSMVLASRGVSPQKALMWSIITSLPQPIVAVPSFIFADAFNKFLPFATGFAAGCMIWMVVAEVLPDGFKEASACHVASAATLSVGFMEALGAIFQNFSNNYSSEDASGFLVSLLFGLGPLLGGVALVAFALALRLQHALLTGVASGVAFILGAWRPVQLLLSSKMGIFPLMLLLAVGSAFVHISTSSALKIGGRKRTSADTLSAATGIQVSALTLQSILCCMAVALHALPEGLALGVAAPKAYGLGQYMVLPVSLHGLPRGAAVASCIFGATDSWHGSLLAAALIGFVGPLSAIGAILGGIDYSGLDHLMVLACGGLLPCFGSIVKRAVKLDKRRTVSGLIVGVGFASICLTFTKLVCLHTPYCNSAPEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIF3</accession>
    <name>A0A068UIF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027110001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIF3"/>
    <dbReference type="FunCoup" id="A0A068UIF3">
        <property type="interactions" value="2501"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIF3"/>
    <dbReference type="Gramene" id="CDP08315">
        <property type="protein sequence ID" value="CDP08315"/>
        <property type="gene ID" value="GSCOC_T00027110001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIF3"/>
    <dbReference type="OMA" id="LDVYMRH"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="316" mass="36770" checksum="7A703F385297D420" modified="2014-10-01" version="1">MNNMSARLSKLDNLYFPRAIQPSATTAAQRQSLLLDLLSRDAAVFLERYGSELTPDELMEFDVLKGDYEINWHLNHLRSVLSPTAEELKSRSTRIKNRRLAYLDKLISDGQYFSEDEMREREPYLHHEFVGKFQDPSGRSMARPGERWSETLMRRSEEAMLVQKIRGEQQRLGVAERDWVGNEEAQEEEESESESESESEEEEEEEEEDGNNDERECMKTRVANGTSQVQEVPIDDISAGNNGQPTASKPAEEESLSLEEMQDRMDQFIYIMKQKFLSGEDHQHMDYSKIDEDESLDDHWMKEANDDAEEKYFDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIH4</accession>
    <name>A0A068UIH4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="10">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00027020001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="10"/>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIH4"/>
    <dbReference type="STRING" id="49390.A0A068UIH4"/>
    <dbReference type="Gramene" id="CDP08251">
        <property type="protein sequence ID" value="CDP08251"/>
        <property type="gene ID" value="GSCOC_T00027020001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIH4"/>
    <dbReference type="PhylomeDB" id="A0A068UIH4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP08251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="468" mass="52327" checksum="DBC624674F0A3EB7" modified="2014-10-01" version="1">MLVELKDRLTQAIRDMKNATVVDESVVNECLNEITRALLRGDVPFHFVKELVNNVKKSANLNNLPSGINKRKILEELTTFYCSLVDDHETACIFSELCNMLNPGKPSFTPRKGKTSVVMFVGLQGTGKTSTCAKYAYYHQKKGWKPALICADTFRDGALDQLKQDAVKVNISYYGSSTESDPTEVALEGLKRSHFLKMRQLYEATKPDLVVFLIDSSIGQAAFDQARAFKQSVSVGAVIVTKFDSHAKGGGAISAMAATKCPVIFIGNGEQLDKFEAFNAKAFVCRLLGKHHPAELVDRFRDSVSLDEQAALCQMFTDGENFTFKKYQAVVRHNYKVWMRQMGPLLLSQVRDLQPNVQENVKPEQMKKYLIMMDSLTSEGNSNPKIMKESRIRRIAQGSGCHVGDVMKMLEHYKQLANMCTRRKMDNMARMISRGRMPSGAGMSGDLMNMFRQLSSSAGMARMLSEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ63</accession>
    <name>A0A068UJ63_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024981001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ63"/>
    <dbReference type="Gramene" id="CDP07658">
        <property type="protein sequence ID" value="CDP07658"/>
        <property type="gene ID" value="GSCOC_T00024981001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ63"/>
    <dbReference type="OMA" id="THHHDIS"/>
    <dbReference type="OrthoDB" id="1928482at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ63"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="126" mass="14565" checksum="FA08AEA8F9966A33" modified="2014-10-01" version="1">MGSESKPNKFHYDLSMSKRTRRSLNLVEDDHDQGSFQAWHGEEESSENDQKKSLKQLIGGRSLSQHFSQEEPQLQLVVKQHDQEGLSGLKFTRMVSRYAKALSHLIKLKRKQQMGLYKKPVLPLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK72</accession>
    <name>A0A068UK72_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TOD1/MUCI70 glycosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027984001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK72"/>
    <dbReference type="STRING" id="49390.A0A068UK72"/>
    <dbReference type="Gramene" id="CDP08866">
        <property type="protein sequence ID" value="CDP08866"/>
        <property type="gene ID" value="GSCOC_T00027984001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK72"/>
    <dbReference type="PhylomeDB" id="A0A068UK72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006852">
        <property type="entry name" value="TOD1_MUCI70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048354">
        <property type="entry name" value="TOD1_MUCI70_glycTrfase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12956">
        <property type="entry name" value="ALKALINE CERAMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12956:SF22">
        <property type="entry name" value="OS06G0724300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04765">
        <property type="entry name" value="TOD1_MUCI70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOD1/MUCI70 glycosyltransferase-like" evidence="1">
        <location>
            <begin position="115"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="442" mass="51544" checksum="A2D8F8B9889368B0" modified="2014-10-01" version="1">MVLYARSWKNFSRDFAARRMMSKVVLFLAFVVAGIVWASMIRIALYSDTWACQSPLSCFSVIWSSRCSKTSNFPDMMRGYAPKPRKRCPIPFAKDPEGLDHSKVRRTPDQLVKGLSYIMQDEPDVNNGWQSLPPFGGGRQKRWFERGESFKLNTTMKVHCGFTRSSGAGMTLADMRYVKGCKYVVASGIFNPYSIIHQPTNVSVHSRKLFCFVMLVDEKILSLMKYRETVEEDIHGGLWAGIWRLIPLKHLPYNETRRNEEISKLLIHRLIPQAQYSIWVSSKMVLVADPLLILERYLWREGHSFAISQHGYHHSIYEEAYASKRRKKYSRPRIDTQMRVYQSEGLEPWSTKKRVISDVPEASIIIREHTMMNNLFSCLWFNEVHLFTPLDQLSFGYVAHRLGGESFKYFMFPFCEFNSLFELHSHSWDRFEMRFGGEINVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULP1</accession>
    <name>A0A068ULP1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ELM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028361001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULP1"/>
    <dbReference type="STRING" id="49390.A0A068ULP1"/>
    <dbReference type="Gramene" id="CDP09149">
        <property type="protein sequence ID" value="CDP09149"/>
        <property type="gene ID" value="GSCOC_T00028361001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULP1"/>
    <dbReference type="OMA" id="VECVKSH"/>
    <dbReference type="OrthoDB" id="1938526at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULP1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46872">
        <property type="entry name" value="DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46872:SF10">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27820" checksum="A00A50D92526E535" modified="2014-10-01" version="1">MKPSKELHIQKENDPVPKGWIEYICDDSLRLAIPVGPRFQADLPALPVSPHKNGQHNMHRKSRSSKWLSIKVWPTKGRSLEVSGDVIGKGRPKSCSCVSPGSVECVRQHINAKKIQLQSDLGPAFWLWKFDSMGEDVSKLWTLEEQKKFKDVVRIHAKSFGQSSINSALECLPCQSRETIVNYHLNVHILRRIAKQTRLGSSRIDTDDESEETPPTKGSRKRLQANHVTSSISKYVKTKYLMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULS3</accession>
    <name>A0A068ULS3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028770001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULS3"/>
    <dbReference type="Gramene" id="CDP09416">
        <property type="protein sequence ID" value="CDP09416"/>
        <property type="gene ID" value="GSCOC_T00028770001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULS3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="85" mass="9025" checksum="22DD5126B47C424C" modified="2014-10-01" version="1">MATQLGRNFSKCLTARHFSAMGGTAMAPPPAHRFFSSEAATNSKKGRVRALVDFMELPYKLGLSAFLGAACGSLAAFIHLDGYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMC2</accession>
    <name>A0A068UMC2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028741001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMC2"/>
    <dbReference type="Gramene" id="CDP09394">
        <property type="protein sequence ID" value="CDP09394"/>
        <property type="gene ID" value="GSCOC_T00028741001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMC2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="106" mass="11278" checksum="0FACEDAB8F4F34FF" modified="2014-10-01" version="1">MLGLSTILPELEYDSRETLALEAIKASAISVANSKPSGRSVHCSANLSKKSLEYFLVITPLPSSPLSLTCFLISEVSNFGVDMSAASSQSSGSTLLWPEFSLDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN33</accession>
    <name>A0A068UN33_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030340001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in environmental stress response.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN33"/>
    <dbReference type="FunCoup" id="A0A068UN33">
        <property type="interactions" value="2360"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN33"/>
    <dbReference type="Gramene" id="CDP09861">
        <property type="protein sequence ID" value="CDP09861"/>
        <property type="gene ID" value="GSCOC_T00030340001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN33"/>
    <dbReference type="OMA" id="SHRPCAN"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4770:FF:000007">
        <property type="entry name" value="Zinc finger A20 and AN1 domain-containing stress-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF98">
        <property type="entry name" value="ZINC FINGER A20 AND AN1 DOMAIN-CONTAINING STRESS-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="166" mass="17928" checksum="4D4E81A509C0B0C6" modified="2014-10-01" version="1">MGSEGNKINDGTSYQPSEPTLCANGCGFFGSPATMNLCSKCYNDFQMEEQQKAAAKVALEKLVTSQKKADDAFHVGSPESYGTAAVQVERQEEAASAPAAVVKSNRCFCCNKKVGVMGFTCRCGSTFCGLHRYPEKHDCTFDFKGQGRDAIAKANPVVKGDKIQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNH7</accession>
    <name>A0A068UNH7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030335001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNH7"/>
    <dbReference type="FunCoup" id="A0A068UNH7">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNH7"/>
    <dbReference type="Gramene" id="CDP09857">
        <property type="protein sequence ID" value="CDP09857"/>
        <property type="gene ID" value="GSCOC_T00030335001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNH7"/>
    <dbReference type="OMA" id="EWESRTF"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46431">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46431:SF7">
        <property type="entry name" value="SNARE ASSOCIATED GOLGI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="145"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="322" mass="35319" checksum="5B84BC0D807AC9CC" modified="2014-10-01" version="1">MENGGAGGGFVVVPVLGWRKAGEEKEEDPNGDYVKLKDDDVEGGYGRVADIGEAVGSASSSSSSSSSSSSSRCSRCWYSIWWWAKLILLVGFLSVLAAVFFKWIGPFFMDKEIIPAINWETKTFSRPVLALLVFGSVALFPTLLLPSSPSMWVAGMTFGYGYGFLLIIGAVIIGVSLPYFIGSLFHHKIQGLLERYPKRASLIRLAGEGNCFKQFRAVALIRISPFPYIIYNYCAVATDVKYVPYLLGSLVGMVPETFLTLYTGILIKTLADASHDRHALSAPQIILNLVGFCATVATTVVVTIYAKRRLKELQKEEELLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQI8</accession>
    <name>A0A068UQI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7054 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030353001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQI8"/>
    <dbReference type="FunCoup" id="A0A068UQI8">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UQI8"/>
    <dbReference type="Gramene" id="CDP09873">
        <property type="protein sequence ID" value="CDP09873"/>
        <property type="gene ID" value="GSCOC_T00030353001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQI8"/>
    <dbReference type="OMA" id="CTDIFAS"/>
    <dbReference type="OrthoDB" id="1885101at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040358">
        <property type="entry name" value="At4g22758-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055482">
        <property type="entry name" value="DUF7054"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270">
        <property type="entry name" value="BNAC05G50380D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270:SF6">
        <property type="entry name" value="OS02G0448600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23156">
        <property type="entry name" value="DUF7054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7054" evidence="2">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="273" mass="30507" checksum="A28C6BB3F01C9BB3" modified="2014-10-01" version="1">MSERDFRRGVPVNRRVKTRPPHPSRSPSPSPAPATRRRRSSREVHRPRSSKLSRRLEIFKRCNSEPALLRARGGGGEHFGQRSLASPEAEGVFYRPQTCADIFSASSDNILLPRSPRISLEGMRYSKDAKVVVNVTVDGSPGPIRAMVKLGSSVEETIKLVIDKYGEEGRTPRLDKDANTTFELHHSYFSLQSLNKLDAIGDSGSRSFYLRKNSSGRSSSASLTPYDLSRNAGSHLPGSSSICLQSFICRKINKFMRRMNKLWKLLGCMNGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQV6</accession>
    <name>A0A068UQV6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00030526001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQV6"/>
    <dbReference type="STRING" id="49390.A0A068UQV6"/>
    <dbReference type="Gramene" id="CDP09998">
        <property type="protein sequence ID" value="CDP09998"/>
        <property type="gene ID" value="GSCOC_T00030526001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQV6"/>
    <dbReference type="OMA" id="ARIMFRL"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQV6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052306">
        <property type="entry name" value="CYP450_71D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953:SF19">
        <property type="entry name" value="OS06G0641600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953">
        <property type="entry name" value="OS08G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="194" mass="22408" checksum="AFDBD5F6EA2D3E04" modified="2014-10-01" version="1">MFQNIFAAGSEASATAMEWAMSEMIRKPQIMKRAQDEVRSLFDGQGNVDESRLHELKYLDAIIKEILRLHPTKARLFVNAWAIGRDPKYWIEAEKFNPSRFLDSRIDFQGDDFEYIPFGAGRRICPGIAFSQPVMQLALAQLLFHFDWKLPGDMKQEELDMTAKFGITMRRKNDLLLIPIPYSRSCLIMDNSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URH7</accession>
    <name>A0A068URH7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7705 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031875001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URH7"/>
    <dbReference type="FunCoup" id="A0A068URH7">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URH7"/>
    <dbReference type="Gramene" id="CDP10917">
        <property type="protein sequence ID" value="CDP10917"/>
        <property type="gene ID" value="GSCOC_T00031875001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URH7"/>
    <dbReference type="OMA" id="YFEVVWE"/>
    <dbReference type="OrthoDB" id="1901892at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056122">
        <property type="entry name" value="DUF7705"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33916">
        <property type="entry name" value="EXPANSIN-LIKE EG45 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33916:SF8">
        <property type="entry name" value="OS05G0272800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24804">
        <property type="entry name" value="DUF7705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7705" evidence="1">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="469" mass="52580" checksum="00326F6ADC2FB248" modified="2014-10-01" version="1">MRRDELRVAFEAWNFCNEVGNEEAPGMGSPRAADCFHISSNGSLIHKVTEVDNKLGVGKPFPGLPEKALNDPNLYAVEKELYLGSLCEVADHTAPTKPWQFWMIMLKNGNYDTRSGLCPKNGEKVPPFISGQFPCFGKGCMNQPLLYHQPTAVVTSENGIKTMKGGFSGTYDLVPFPPPFGIGTLGDSSLNSYFEVVWEKKVGDGGSWIFRHKLRTTKFYPWLMLYLRADATKGFSGGYHYDSRGMLKILPESPNFKVKLTLDIKQGGGPKSQFYLMDIGSCWKNDGRPCDGDVLTDVTRYSEMIINPETQAWCSPASMNRCPPYHITPNNIKILRNDTAHFPYSAYHYYCAPGNARFLEFPDSTCDPYSNPQAQELVQLLPHPVWAEYGYPSKRGEGWVGDGRTWELNVGALSSRLYFYQDPGTRPARRIWTSLDVGTEIFVSNKEEVAEWTLSDFDVILTSQPPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URX6</accession>
    <name>A0A068URX6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00033407001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739137">
        <property type="protein sequence ID" value="CDP11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068URX6">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URX6"/>
    <dbReference type="Gramene" id="CDP11270">
        <property type="protein sequence ID" value="CDP11270"/>
        <property type="gene ID" value="GSCOC_T00033407001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URX6"/>
    <dbReference type="OMA" id="HAGSDCA"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URX6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010928">
        <property type="term" value="P:regulation of auxin mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06410">
        <property type="entry name" value="PB1_UP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000142">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000058">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000081">
        <property type="entry name" value="Octicosapeptide/phox/Bem1p domain kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF957">
        <property type="entry name" value="F3O9.7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1041"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1072"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP11270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1326" mass="146753" checksum="BB635D2D5916C600" modified="2014-10-01" version="1">MERNVGKGMMGQPKNYEQVRYSSVETRAEGIGSANQRFFQDPASSINTNIRPPEFGIPVVARPVLNYSIQTGEEFALEFMRDRVNPRQQFIPNASGAEHSGASSYTDLKGILGITSTGSESGSEVSMIPSAGKSQVQVHQRNNSMATEEKDFYQPVQTVIRSSSGNNISHGVHNRGQPRSVDTSAAKLKFLCSFGGKIMPRPSDGKLRYVGGETRIVRVNRDISWEELLQKTMAIYNQTRVIKYQLPGEDLDALVSVSCNEDLRNMIDECNVLEEGGSQKPRMFLFSPSDLDDSQLSLGSMEGDSEFQYVVAVNGMDFGSRRNSIGLASTSGNNLDELLGFSVERESSRVAADLTGSNTAQPMDEMYVSSQSSQTMEQSLSHAFESNPHSYHGNKVLGEVEMRLLPNFQQRESLPKTDGQSFVQSSATLQYTYNSHGSHQPVNVENLVPHSSQGHIVRQGGLTQEQPYVSLLIHKPEPLATEMKINRDNSIKKKSESYTDQSVDNDVLVKETKMRRENSTQRITETEKMQPSGGKNIVSSTQHDFYASDLASKDEASVARSAEHPGPAAVHLKTSEKDQEPLQNSVTPEAFEEEKADKFNEEGHLYLSGKASANGCGDLDTHPTDASHEPQVLAQRIFRSERIPREQAGLNRLSKSDDSSSAQFLITHTQSDVAQHFTESVDRLHERNADGTESSDKMQERNVASQTEKFLPSGKPQHHHLPATGNKREVTEKSIEADSKATFPNSSISQEASGSNLQKSEQKAPVIPEKEISGSSCLAASQGISEKVHDESTAKLMELPLGEIAAIKMDPSTKKVQILPTVGKEHPVAASPEEKPSTSVSVQEQGDILIDINDRFHPHFLSDMFSKAKIDGTRVAPLPSDGNGLSLTMENHEPKRWSFFQKLAQDDFVRRDVSLIDQDHVGFSPRTNVEDVSVDYSYAPSRDVGVAVGHIDSRINFGSDVQQQSRGFVEPNTMNVPTDYNPSQTTSLQSMQFDGPMNSRIPESDYQDEKIEAQHAGFPLIDLSLVDFDPSSLQIIMNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLTVEFWREAEILSKLHHPNVVAFYGVVQDGPGGTLATVTEFMVNGSLRHVLLSKDRHLDRRKRLTIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNLKDPSRPICKVGDFGLSKIKRNTLVTGGVRGTLPWMAPELLNGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPPVPSYCDPDWTLLMEQCWAPDPAARPSFTEIARRLRLMSTAGPTRTQGYTKQNQLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USD6</accession>
    <name>A0A068USD6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00033724001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USD6"/>
    <dbReference type="FunCoup" id="A0A068USD6">
        <property type="interactions" value="1203"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USD6"/>
    <dbReference type="Gramene" id="CDP11460">
        <property type="protein sequence ID" value="CDP11460"/>
        <property type="gene ID" value="GSCOC_T00033724001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USD6"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USD6"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000199">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009251">
        <property type="entry name" value="PRK12607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="11">
        <location>
            <begin position="110"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="409" mass="45944" checksum="C5A12FF01A62B805" modified="2014-10-01" version="1">MAQNCIGGALNPSKTLTPKCIPINHPNPSSLSSSSLRKFILTKSKKCLPPSIFISASMSSSQQHQPPLSLEALKTSERRNEVLNAIQSSLSNCLSETHLDLTVPGLKSKTTGKVRDIYDEGNYLVLVTTDRQSAFDRVLASIPFKGLVLNETSLWWFNKTQHIVPNAVVSAPDKNVTIAKKCSVFPVEFVVRGYVTGSTDTSLWTVYKKGVRNYCGNVLPDGMVKNQKLPENILTPTTKAADHDVPVTPDEIIQRGLMSRADYEEASKRALQLFEYGQRVAMKHGLILVDTKYEFGKAPDGTVLLVDEVHTPDSSRYWIGHSYQERFWNGLEPENVDKEFLRLWFNDHCNPYEDEVLPDAPEELVSELAWRYIFLFETITNSSFEIPTTKEPIHDRITQNVSQALKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTH2</accession>
    <name>A0A068UTH2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033967001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739141">
        <property type="protein sequence ID" value="CDP11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTH2"/>
    <dbReference type="Gramene" id="CDP11607">
        <property type="protein sequence ID" value="CDP11607"/>
        <property type="gene ID" value="GSCOC_T00033967001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTH2"/>
    <dbReference type="PhylomeDB" id="A0A068UTH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="55" mass="5911" checksum="3F7D9F671FD87848" modified="2014-10-01" version="1">MLDLKMTILITSNGACKLGAFGFTPTGHSSGDSANVRAFHYAVSVNFHITVKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTU6</accession>
    <name>A0A068UTU6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpene synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035118001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739144">
        <property type="protein sequence ID" value="CDP11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTU6"/>
    <dbReference type="STRING" id="49390.A0A068UTU6"/>
    <dbReference type="Gramene" id="CDP11851">
        <property type="protein sequence ID" value="CDP11851"/>
        <property type="gene ID" value="GSCOC_T00035118001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTU6"/>
    <dbReference type="OMA" id="SHNDERE"/>
    <dbReference type="OrthoDB" id="1936865at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF252">
        <property type="entry name" value="TERPENE SYNTHASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="303" mass="35071" checksum="D537F20C7519C632" modified="2014-10-01" version="1">MANILEFLPLRYTYSSGILSKNGSKRALHHLHGARIPWRTRCSITASSIEAYHDSEPAISTRRSANYQPSSWSHVLAESMDEKDNEWEIQMTILKKLEEEVRYMLDDENLEPQSLLELVHDIDRLGISYKYRGTIRDAPDRLKSLKEATTEITKDLHLSALYFRLLRQHGYEASPDIFERFRDRSGNFGNLGRSLAKDVRGILSLYEASHLAYEGEDTLQEAKSFTSLHLKSSKELVDSNMSEEIKHALELPYHHRMRRLEARWNIETCAKRNGKNQILLELAKLDFNKVQSVLQGDLQDVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVD2</accession>
    <name>A0A068UVD2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036122001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739151">
        <property type="protein sequence ID" value="CDP12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVD2"/>
    <dbReference type="STRING" id="49390.A0A068UVD2"/>
    <dbReference type="Gramene" id="CDP12515">
        <property type="protein sequence ID" value="CDP12515"/>
        <property type="gene ID" value="GSCOC_T00036122001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVD2"/>
    <dbReference type="PhylomeDB" id="A0A068UVD2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="74" mass="8680" checksum="E1317046032DF709" modified="2014-10-01" version="1">MLCMDIMLCRLQKSVFVYIFLYVFRLCRAMGGVERKVEIEWGNHVVSSRVQEAVQAILNFVKREGPKGWDDPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVR1</accession>
    <name>A0A068UVR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00035844001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVR1"/>
    <dbReference type="STRING" id="49390.A0A068UVR1"/>
    <dbReference type="Gramene" id="CDP12354">
        <property type="protein sequence ID" value="CDP12354"/>
        <property type="gene ID" value="GSCOC_T00035844001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVR1"/>
    <dbReference type="PhylomeDB" id="A0A068UVR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="289" mass="32539" checksum="72864A07B0015453" modified="2014-10-01" version="1">MVEIINSEKMSNKYLRSFLRGFLCFSKRKIKNIELHFNLVKTIRKKILRNSNVEKNLSINVEVERKLAHNSSGLQGFLVFHAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTICPSPQVSIAVVQPYNSVLSTHSLLEHTDVSMLLDNEAIYDICRRSLDIERPTYINLNRLLFALVKCGITLHVVSSPFIYLAGIFGNVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMHSSYAPVISAEKAHHEQLSVAEITNSAFEPWFKDSVESSLERGFPIRYRDEMTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWV0</accession>
    <name>A0A068UWV0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00037595001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWV0"/>
    <dbReference type="FunCoup" id="A0A068UWV0">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWV0"/>
    <dbReference type="Gramene" id="CDP12906">
        <property type="protein sequence ID" value="CDP12906"/>
        <property type="gene ID" value="GSCOC_T00037595001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWV0"/>
    <dbReference type="OMA" id="CMSHAIM"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWV0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="14031" checksum="F358B361DF9B578A" modified="2014-10-01" version="1">MEAVRRLGSEKPVVIFSKSNCCISHAIKMLICSFGANPTVYELDYHPKGREIENALLALGSHTSVPAVFIGKLFVGGSNEVNYEPQCPGQVKAINAYQGQGYMGCDNHLQPFPSKQFSFGFFLPKRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXA3</accession>
    <name>A0A068UXA3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00037570001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXA3"/>
    <dbReference type="FunCoup" id="A0A068UXA3">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UXA3"/>
    <dbReference type="Gramene" id="CDP12889">
        <property type="protein sequence ID" value="CDP12889"/>
        <property type="gene ID" value="GSCOC_T00037570001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXA3"/>
    <dbReference type="OMA" id="FDRHAQD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXA3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56607" checksum="65CAC2EE552E26DB" modified="2014-10-01" version="1">MALFSLGYFEIFLAIICFFYLRNLRSFKRLAWKLPILGTFPYLIMNIHRIHDKCAEVLEKTRGTYHLKGPSFANMDILGTVDPANVHYIMSSNFVNFPKGPEFKKIFEVLGDGIFNSDLDLWKCQRKLARALLNHQSFHKFLQGLMVDLQDVFQRLTFDTTCKFVTGYDPGCLSIDFPGVPFSKAMDEVEEAIFMRHILPEIVLKLERWLGIGQEKKLSKSWKILDEVICKYISVKQEELKKGTKSTNDEEGFDLLTSYINLGDNEITTGLKRDDKFLRDTIINFMIAGRDTTSSALTWFIWLVSTHPTVLNKIREELKSVIQVNEEAENFRLFKVDELKNLVYIHAALCESMRLYPPVPFQHKFPLQPDTLPSGHRVHPKIKVIFSLYAMGRMKFIWGKDSWEFKPERWISERGTIKHEPSYKFLAFNAGPRTCLGKEVAFTQMKAVAAAMIHNYNVEMVEGHPVVPNLSVILYMKHGLKVRVSKRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZC6</accession>
    <name>A0A068UZC6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00038664001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SFH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZC6"/>
    <dbReference type="FunCoup" id="A0A068UZC6">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZC6"/>
    <dbReference type="Gramene" id="CDP13647">
        <property type="protein sequence ID" value="CDP13647"/>
        <property type="gene ID" value="GSCOC_T00038664001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZC6"/>
    <dbReference type="OMA" id="IQMWDEM"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZC6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL_PHOSPHATIDYLCHOLINE TRANSFER PROTEIN SFH13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="143"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="599" mass="69540" checksum="6E00602B82E334D1" modified="2014-10-01" version="1">MSGLEGMETYDETRERRSDFENSEDERRRFKIGTLKKKAINASNKFTHSLKKRGKRKVDCRVPSVSIEDVRDATEEAAVYELRQKLLDRDMLPAQHDDYYTLLRFLKARDFNTEKTIQMWEEMLKWRKEYGTDTILEDFEFEELEEVLQYYPQGYHGVDREGRPVYIERLGQAHPAKLMRITTIDRYLKYHVQEFEKAIYEKFPACSIAAKRRICSTTTILDVQGLGAKNFSRTAANLLASMTKIDNNYYPETLHRMFIVNAGPGFKKVLEPKSLGKLLEAIDSSQLPDFLGGSCSCPVEGGCLRSNMGPWNDLDIMKLVYNVETKFVRQITRVSGDDQKVDLYTQTFPLKGRSSYTSVVESGLDVDDSCSPTRKSSFTFPRLAPLHEEARTSESPVYYSCDDLFSEVDTHGGNEQEIDNSQYQSPAIYNAGRRAILEGTLVIHWFETIQEKVVKRSLRFMSRTIIQIIFKLFEAIRNVPFDHSRRQTNIYPSNALEEQPENHSSVSAQAIGEGYQVLPCVQRLQRLEKLLEELNNKRHEIPMEKEQMLQQSMDRIKCVEMDLEKTKRVLHATVVKQLEITELLESIRESKFRQRKFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V154</accession>
    <name>A0A068V154_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein GAST1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040465001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V154"/>
    <dbReference type="STRING" id="49390.A0A068V154"/>
    <dbReference type="Gramene" id="CDP14204">
        <property type="protein sequence ID" value="CDP14204"/>
        <property type="gene ID" value="GSCOC_T00040465001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V154"/>
    <dbReference type="OMA" id="GMITESP"/>
    <dbReference type="OrthoDB" id="847210at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V154"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF52">
        <property type="entry name" value="OS05G0376800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655430" description="Protein GAST1-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12839" checksum="1C75D5FA55F86ED9" modified="2014-10-01" version="1">MAKNLSSNVTIHVLMLFLLISRNHGMITESPSPSPQPQPSGLFPTHGITPGSLHPQECSPRCTYRCSKTAFKKPCMFFCQKCCAKCLCVPPGTYGNKQFCPCYNNWKTKRGGPKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1L9</accession>
    <name>A0A068V1L9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041065001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1L9"/>
    <dbReference type="STRING" id="49390.A0A068V1L9"/>
    <dbReference type="Gramene" id="CDP14546">
        <property type="protein sequence ID" value="CDP14546"/>
        <property type="gene ID" value="GSCOC_T00041065001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1L9"/>
    <dbReference type="OMA" id="MELLYYY"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1L9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF24">
        <property type="entry name" value="OS04G0560500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="553" mass="62533" checksum="274DA801AE5AA05C" modified="2014-10-01" version="1">MLGGSWRFSFTITIAPPCFSNKRKYSAAATTTTTSGYGFYCRALEDQQQTQLTSTTLSGSQNKKKVVIVGSGWAGLAAAHHLCKQALDVTVLEGGYEFGPKNRTLAPDDVGIRGFWYPYKNIFNLVDELDIKPFTKWTTSAVYSGDGLEVKFPLFQEVPQLPTPFGTLLYTQLARLSMVDMLTSLPLMAAVIDFDNTDAAWEKYDPITARELFRQFGCSERLYRYVLDPLLQVGLFAPAERCSAAATLEILYYFVLAQQRHFDLVLCRGTVKDKIFRPWMDSLKSQGCKFLTGRKVTDITIDEETGCISEVVCGKESLKADANSSYFSWLLFSNTSAALCTREEFLKVLNLDSIDLLTVKLQLDRKVSIPNASNVSSRFDDSTGWTFFNLNMIYDEHNDDLGTVVQADFYHANDLLPLKDEIIVKRVMSCLSKCIGDFEKAVVVDKDIERFPKYLPHFFPGSYKYMMRGSTSFPNLFMAGDWIISRHGSWSQEKSFVTGLEAANRVVDYLEVGTFAKIIPVEEDEPHIQAFRSLNRNLDELRGQLPWSDYFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V254</accession>
    <name>A0A068V254_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00042015001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739174">
        <property type="protein sequence ID" value="CDP14637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V254"/>
    <dbReference type="STRING" id="49390.A0A068V254"/>
    <dbReference type="Gramene" id="CDP14637">
        <property type="protein sequence ID" value="CDP14637"/>
        <property type="gene ID" value="GSCOC_T00042015001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V254"/>
    <dbReference type="OMA" id="MHGDREF"/>
    <dbReference type="OrthoDB" id="551849at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V254"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001351">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000526">
        <property type="entry name" value="serine/threonine-protein kinase BRI1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000150">
        <property type="entry name" value="serine/threonine-protein kinase BRI1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002765">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF800">
        <property type="entry name" value="OS11G0197000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="987"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1014"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP14637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1265" mass="138122" checksum="74FACAD9CCA5A050" modified="2014-10-01" version="1">MPKLIFRYQVCHVLTIILAFVIYPALTHGIFLGDVELLKALRQSLISRRNAIPSWFESETSPCNWTGIRCEGAVVRQIDLSCTNSPLSLPFPVLIGEFKSIKYLNLSHCALTGGFPESVWNLENIESLDVSDNRLTGMLPPTISNLKNLRQLVLDDNSFSGSFPSAIGLLEELLELSVHGNLFYGNIPEELGNLKKLQSLDLSVNNFSGRLPSSFGNFTRLLYFDARQNKLSGPIIPEIGNLRRLRTLDLSWNSLTGPLPITIGNLKHLQSLDLQNCRISGNIPEEITELRSLTYLNLAENIFKGELPESVGRLTNLNYLIAPNAGLTGKIPPQLGNCKRLKIINLSFNSLSGPLPEDLAGLESISSVLLDSNCLSGPVPGWISNWKEVESIILSKNLLSGSLPPLDLPLMSSLDLSSNKLSGELPSEICNAKSLSNLQLSDNNFTGSIDKTFSNCLSLTDLVLSENGLFGEIPAYLGDLQLITLELSKNKFSGKIPDQLSESKTLMEISLSNNMLEGPIPSAIAKVSTLQRLQLDNNLFEGSIPVSIGKLKNLTNLSLHGNRLTGEVPLEIFECTKLVSLDLGANRLTGPIPKSISQLKLLDNLVLSYNQFSGSIPEEICSGFQKVPLPDSEFVQHYGMLDLSNNDLEGQIPASINKCIVVSKLNLQGNRLNGSIPFEISGLPNLTSVDLSFNSLTGPISPHLTSMSLQGLNLSHNQIKGAIPENFGSKMSSLVKLDLSHNLLSGPLPPSIFNIVSLTFLDISQNSLSGTLSVGPGSTSSLLFLNASFNQLSGNLCDSLSNLTSLSMLDLHNNSITGTLPLSLSSLAALTYLDLSNNNFQSSFPCNICDIEGLAFVNFSGNKFTGNVPDTCKDTEICLLNQNIFLHRHRDSSPVILSHASVLGIALGATLVSLIILIGLVRWRMLRQEAMILERGSNKIVGATEPASSDELLVKKPKVPLSINIATFEHSLLRINPADILSATENFSKSYIIGDGGFGTVYKASLPGRTFAVKRLNGGHLHGNREFLAELETLGKVNHQNLVPLLGYCVFADERFLIYEYMENGSLDFWLRNQADAIQALDWPTRFKICLGSARGLAFLHHGFVPHIIHRDIKSSNILLDRNFEPRVSDFGLARIISACETHVSTVLAGTFGYIPPEYGQTMMATTKGDVYSFGVVILELLTGKAPTGQADIEGGNLVGWMRWMVARGRESEVLDPYLSASSAAWKTQMLEVLAIARRCTCDEPWKRPTMLEVVKLLKGAKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3D4</accession>
    <name>A0A068V3D4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00042748001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC). The NPC has an eight-fold symmetrical structure comprising a central transport channel and two rings, the cytoplasmic and nuclear rings, to which eight filaments are attached. The cytoplasmic filaments have loose ends, while the nuclear filaments are joined in a distal ring, forming a nuclear basket. NPCs are highly dynamic in configuration and composition, and can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160 subcomplex and the NUP93 subcomplex, containing approximately 30 different nucleoporin proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3D4"/>
    <dbReference type="STRING" id="49390.A0A068V3D4"/>
    <dbReference type="Gramene" id="CDP15151">
        <property type="protein sequence ID" value="CDP15151"/>
        <property type="gene ID" value="GSCOC_T00042748001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3D4"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3D4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000002">
        <property type="entry name" value="nuclear pore complex protein NUP98A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF19">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="9">
        <location>
            <begin position="716"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="858" mass="90492" checksum="1B6EC7390DA02252" modified="2014-10-01" version="1">MFNSSPTTYYSFGFGQSASAASPFGCQSGFGANTDLSNSNPFAPSGATPFAASTGATMFAGNSTTGAGAFSQPAISSTPFGSASVFGQTTGSYATATACVSASTGLATPTGFGQWTNSSPSGSQSVFRQGSNSCNNNFFGTAATPFATSTGGSMFSGNSNGAFGASSFAFGSSASSTTAPFSTTFETSALPSTVFSQAPSSAPVVSQSAFGEVSKFDVNNSFSSKPVTATPFGSISGGAIFGGNSTSKSPFGVTSSPSTSKSPFGEPLPFSFGILSTTTGAPIFNNIGSLIQPSQSKSTNHAFYSSSQSVFGSSGVLASGISTSVYSGFQHGGSCSRPPFSSTGLAFSSNGAPNNFNSVSRGAIGSSTTPITGAPSNFNTVASNNPELQNSRFTFCQPNSQFSEPNLQFGSNNGPTAWETKKFYSGYQPASTSMKSGQSVMDCQRYGSKIASSVATKEVDIGSTEPAGKLFSISAMPFYKDKSHEELRFEDSNQLLRSKDAASGFIFKSNQPSAGKTNAFSGPTVVSLDSQSESLSAISTGTGLLTSNSSDFIWPNYDFRSESQSTIALDPSVVASPFGMESRIQISMGGRAATTTVQYGISCIPVSDKPAPVKRNSLLTARCLSLSQNWPSVEKYRPKNDSQKVPFYEEKVPGIYKVGASFIPRENARSWVLNSMVERPLKTNSRNSSLLEESVSASESGNFEADVEAILPKLQCPDYYIKPPVEELAAKERAEPGFCRRVKEFVVGREGYGSIRFLGETDVRNLDVESVIQLNHREVIVYRDTTKKPQVGQGLNKPAEVSLLNVKCINKRTGKQYAEGTRVDKWTDMLKTKAEEQGAEFLSYNPVTGEWKFRVQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V664</accession>
    <name>A0A068V664_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pectinesterase</fullName>
            <ecNumber evidence="3 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00016998001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3 11"/>
    <dbReference type="EMBL" id="HG739198">
        <property type="protein sequence ID" value="CDP16019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V664"/>
    <dbReference type="STRING" id="49390.A0A068V664"/>
    <dbReference type="Gramene" id="CDP16019">
        <property type="protein sequence ID" value="CDP16019"/>
        <property type="gene ID" value="GSCOC_T00016998001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V664"/>
    <dbReference type="OMA" id="YRECTIY"/>
    <dbReference type="PhylomeDB" id="A0A068V664"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000029">
        <property type="entry name" value="Pectinesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="95"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP16019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="318" mass="35886" checksum="9614A1E2EC31521E" modified="2014-10-01" version="1">MDAIASAPIQSQSRYYIHVEAGIYEEIVEVWGNKTNIALIGDGENLTKITMNRRFPEFKTYKTATVFSQFMFFLTLSHLVILPFYLKALQSVSFCYRFMAKYITFENSAGEGSQAVALMSESDQSSFCRCSFLGYQDTLYAKSGKQFYKECDIYGTVDFVFGDAAAVFQSCNLYAWLPNRIITFTAQGKKIPNQVSGFVIQNSTLTAAPDLQSNKSQVHAFLGRPWFAWSTVIVMQSYLDSIIDPAGWYEWPGHRTDELTYIEYGNWGPGAGTGRRISWVGYKALNQSEEVIPFTVSKFITGDSWIPETGVPYTSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6T3</accession>
    <name>A0A068V6T3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014504001</name>
        <name evidence="3" type="ORF">GSCOC_T00018215001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739207">
        <property type="protein sequence ID" value="CDP16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6T3"/>
    <dbReference type="Gramene" id="CDO97234">
        <property type="protein sequence ID" value="CDO97234"/>
        <property type="gene ID" value="GSCOC_T00014504001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16376">
        <property type="protein sequence ID" value="CDP16376"/>
        <property type="gene ID" value="GSCOC_T00018215001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6T3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="63" mass="6682" checksum="90C6A243B9A51D9C" modified="2014-10-01" version="1">MAEEEACLFAMHLASASVLPMVLKLAIELDLLELIATAWIAVLAFAGTAKNLTLGNLLVALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7R4</accession>
    <name>A0A068V7R4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S ribosomal protein L18, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00019329001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739220">
        <property type="protein sequence ID" value="CDP16810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7R4"/>
    <dbReference type="FunCoup" id="A0A068V7R4">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7R4"/>
    <dbReference type="Gramene" id="CDP16810">
        <property type="protein sequence ID" value="CDP16810"/>
        <property type="gene ID" value="GSCOC_T00019329001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7R4"/>
    <dbReference type="OrthoDB" id="1932324at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7R4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF8">
        <property type="entry name" value="RIBOSOMAL L18P_L5E FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP16810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23134" checksum="6239C8613597E9CB" modified="2014-10-01" version="1">MAAMGALISGLQQLQLKTCQLFGTSDLHHFDNILPKKRASLKPLVIEAKANAKTESAKTRNIRLRKKAYSASFIFDAILICGITCLVFLLFHLSLQIMVLASLDQFNGTATKPRLSVFCSDKQLYAMVVDDQNKRCLFYGSTLQKSIRQDLSCTTIEAAQRVGEELVKVCIDLDINEISSYDRNGLARGDRMQAFEIAISRHGFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V889</accession>
    <name>A0A068V889_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00019236001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V889"/>
    <dbReference type="FunCoup" id="A0A068V889">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V889"/>
    <dbReference type="Gramene" id="CDP16752">
        <property type="protein sequence ID" value="CDP16752"/>
        <property type="gene ID" value="GSCOC_T00019236001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V889"/>
    <dbReference type="OMA" id="PFFCCIF"/>
    <dbReference type="OrthoDB" id="2425403at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V889"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680:SF1">
        <property type="entry name" value="OS05G0489500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680">
        <property type="entry name" value="OS07G0190500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="553" mass="61449" checksum="08EEE49066916381" modified="2014-10-01" version="1">MVDEDHPTTSRRMTSSSGSVLCVCGAGVCLLLTSKSQANPGRSYYRCPASNRGCGFFRWLDQVRPDQLIFNIPQCGCGAGICRLDIKTTTGPNAGRKCFVCPIKKGQGACNFFMWLDAHSNAATAFQCSRSRRPTSSLLKRDKIILEESKGSDDDPLRKHCKRLRHGDSKSNGCPSGSSTTCQRTPLASSGSYLTEKDGQDSSPTIEMAVHQKKPDFGRPIFFENTLTASKSFLFSRHQSSVLPINLEGLQETSWIVTAIRQNLCLEIKGWWGRLAFPPSKGLKEQSAEPFFCCAFPSFDPIFVPPNVNLLSDDVSVAPVASPLGASRQSSLTLSEGAQLLGTEENSIMRKLVSEAFVKAAEQLQSDLLTLLRSLDIQDHEFMVREADATFDALDQLQIEHKKYSEQVKEYIRCASLLAKINQSVISDHSCRMLADRYSHEKLKLDEIDDAYARDVAALSVSEQRAEYFAIEISHLKDKLFQTEAGLSCCMAESTALKARILGISEDKEIIERSFEMTCKQLEDARKMRKQREAEEHAAKAAFQNAKTLIWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8X0</accession>
    <name>A0A068V8X0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00005015001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8X0"/>
    <dbReference type="FunCoup" id="A0A068V8X0">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8X0"/>
    <dbReference type="Gramene" id="CDP17096">
        <property type="protein sequence ID" value="CDP17096"/>
        <property type="gene ID" value="GSCOC_T00005015001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8X0"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8X0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000063">
        <property type="entry name" value="Mitochondrial nicotinamide adenine dinucleotide transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000105">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="214"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="317" mass="34423" checksum="0C1992DF2FADB088" modified="2014-10-01" version="1">MTGDTTHLFSSRGLLCNAGAGAAAGVIAATFVCPLDVIKTRLQVHGLPKLAGANIKGSIIVGSLEQIFQKEGLRGMYRGLSPTVLALLPNWAVYFTIYEQLKSLLCSDGVNHQLSIGANMLAATGAGAATTIATNPLWVVKTRLQTQGMRNGVMPYRGTLSALRRIAHEEGIRGLYSGLVPALAGISHVAIQFPAYEKIKLYLANRENTTMDKLTARDVAVASSVSKIFASTLTYPHEVVRSRLQEQGRHSEKRYSGVVDCIKKVFQQEGVPGFYRGCATNLVRTTPAAVITFTSFEMIHRFLINNLFPPDPQRHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9V8</accession>
    <name>A0A068V9V8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00009344001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739236">
        <property type="protein sequence ID" value="CDP17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9V8"/>
    <dbReference type="FunCoup" id="A0A068V9V8">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9V8"/>
    <dbReference type="Gramene" id="CDP17284">
        <property type="protein sequence ID" value="CDP17284"/>
        <property type="gene ID" value="GSCOC_T00009344001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9V8"/>
    <dbReference type="OMA" id="CGRSACI"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9V8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000022">
        <property type="entry name" value="Aspartyl protease AED3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000040">
        <property type="entry name" value="aspartyl protease AED3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF798">
        <property type="entry name" value="ASPARTYL PROTEASE AED3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655570" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="103"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="438" mass="46931" checksum="50CCC47F16208CA6" modified="2014-10-01" version="1">MRPAFLHPLQAALLALSFLFLSLAQGLSLKSCTTPDQGSTLQVYHVYSQCSPFKPKTPLSWEESVLQMQSKDEARLLFLSSLVAGRSVVPVASGRQITQSPTYIVRVKVGTPAQTLLVAMDTSNDAGWVPCNGCVGCGSTVFESTKSTTFKNVGCGSAQCQQVPGPSCLGSICSFNLTYGGSTIAANLSQDTIRLAADPVPNYTFGCIQKATGSSVPPQGLLGLGRGPLSLLSQTQNLYQSTFSYCLPSFRSLNFSGSLRLGPNSQPKNIKYTQLLRNPRRSSLYYVNLIGIKVGRRVVGIPPEALAFNPTTGAGTVIDSGTVFTRLVQPAYIAVRDEFRRRMGNAVVSSLGGFDTCYTVPVTVPTLTFMFSGMNVTLPQDNFLIHSTAGSITCLAMAEAPTNVNSVLNVIANLQQQNHRILFDVPNSRLGVARETCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA35</accession>
    <name>A0A068VA35_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00002847001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739243">
        <property type="protein sequence ID" value="CDP17422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA35"/>
    <dbReference type="Gramene" id="CDP17422">
        <property type="protein sequence ID" value="CDP17422"/>
        <property type="gene ID" value="GSCOC_T00002847001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="115" mass="13050" checksum="164555D4ACF6622D" modified="2014-10-01" version="1">MLLRQPADFWQPRLELGLNQRITETTFLYSPDSIHKLNAVPAREGDLPLNCSKPLLKKELLPSIQNRIERSFCNARPISLIALTDGLLYIMCSCQVHNLSFGKEESPLSITNRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAD6</accession>
    <name>A0A068VAD6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00011037001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739252">
        <property type="protein sequence ID" value="CDP17557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAD6"/>
    <dbReference type="Gramene" id="CDP17557">
        <property type="protein sequence ID" value="CDP17557"/>
        <property type="gene ID" value="GSCOC_T00011037001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAD6"/>
    <dbReference type="PhylomeDB" id="A0A068VAD6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="161"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="416"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="647"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1174" mass="134260" checksum="0B7C9CE07EEA64E5" modified="2014-10-01" version="1">MADAAVSATIQVALQAVVSLAADHVNLAREFPEELKKLDKSAAMIRGFLAGADEDKHSPVVQNWLKQLEEEVFKADNVLDELNYENLRRKVKYQNQLTKKTVFFCFSFFNKIGFRSRLGSVIREINTNLQRIHRDAEATTSRQTDSTIVRRDVLGRDKDESEIVKKLLTESESVISVIPVTGMGGLGKTTLAKAIYENEQIVGHFDKKIWVCVAEKVDRIEEVFKMILESLIGGKVEGDRREEIVQKIQHELKEKRYFLVLDDLWNDQEVLLNDFFSTLAGINAKKGSWCLVTTRLQEVETILSRHPQINFIRHEIGRLCDNDCWSIMKKWANVGEEVPKELEDMREQVLRRCDGLPLAAKLIGGLLSKKRKEEWLSILEESLLNRDQGGIEQIVKVSFDHLSPAPVKKCFAYCSIFHQDTRLEQDPLVELWMAEGFLQLDSRNERMMEKIGCEYLRILVQTSLLEEVKDEWGTWYKMHDLVHDFAKSILNRNSSNQDRYLAVYSPERINEKASASLRTLFLQGGIADDMLSKFKYLHVLKLFGADVKELPTSIGKLIHLHLLDISDSMITTLPESLCKLYCLQTLRIGKLEEGFPKEMSNLISMRHLHYYDDAERKIQMPSGIGRWTCLQTLEFFNIGRQKEGRGIQELGTLQDLKGSLEIRNLELVYGKDDAELANLSKKPNMYRLVFEWGNGDRESDKCDEDVLEGLQPHPNLTELHIRNFRGDQVPQWLVKSSTLVELRLVNCRELPTLGQLSSLQHLYLTGLENTTCIGLSFYSSSTISTQTFFPSLKILSLESMKNLEEWKDAHEIHVMDVFPVLEKLSISDCPRLTTIQLQVISQVLMYWKSQRISMFGWQKSIVGCNSLPADMLERLCLFPTLQRVELTSAHNITTLRGMSCAACLKILRVFNCGNLRELPEDLYQFQALEYLEIQYCPRIDSFGHPNPKNSFGQKSLLKPLEEFTVEGCDALTRLPVEMFESCTSLRELKLVRCGSLVSFPLDLRRTPSLESFSLFGCPNLTAELPSGFGYLTSLREVTIGPFSYYSAIEFDWAGLASSSSLRHVSLLGMRDTKSLPHQLQVSTTITSLSLHHFGAIEALPEWLGNLASLEDLILYYCRKLEYLPSLAAMERLKLRRLEIDGCPLLEQRCTPQSSSEWPKISNIPELEIYYKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCL3</accession>
    <name>A0A068VCL3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00002863001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
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                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00002863001"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Palm domain of DNA polymerase"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="357" mass="40967" checksum="A8BEED0BBDEFEE4A" modified="2014-10-01" version="1">MKEFSMPGGVPVWHGNLGGKDLDRMFGFIEAYVVCPKTIKRPFLPYRDKNNTLIFPTGEFVGVYYSEELKYARGLGYTVLPISGYLFEKMKSPFRDFVSSLFESRLEARKSGNEALAYVYKILMNSLYGRFGINPKSTITEVCDVDRYKHLVRHSELIFGDMLSENNYIVAYHSNTGTDSDFWNPPKISAVQLAAAITANARIHMYPYISRDDCYYTDTDSVVLGQPLPEEVISSSVLGKFKLEDRIQKGYFLAPKTYLYITIDDTKVIKYKGPAKSIIYPEWFELQYADPSRTEQVLVSANFRIEWRTLDMIKKETLIRLGIKLDTKRKPVFRGNLWVDTIPIEVTDLSCLNNIGK</sequence>
</entry>
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    <accession>A0A068VCR7</accession>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
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                <person name="Andrade A.C."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome I"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="82" mass="9205" checksum="B3330580DF67B658" modified="2014-10-01" version="1">MPNTNPEFPKQVCKTQKTVIGISQSIQVQMPKFQRHMIAKTFSYISSEDTNSKIQTNSSQKGQLLSQFSHSDQSRTATVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCT0</accession>
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        <recommendedName>
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    <gene>
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    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Combes M.C."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome IV"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bromodomain_CS"/>
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        <property type="entry name" value="GTE_bromo"/>
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        <property type="entry name" value="NET_dom"/>
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    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
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    <dbReference type="PANTHER" id="PTHR45926">
        <property type="entry name" value="OSJNBA0053K19.4 PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="286"/>
            <end position="358"/>
        </location>
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        <location>
            <begin position="458"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="36"/>
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        </location>
    </feature>
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            <begin position="568"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP18387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="70226" checksum="F80B751C8FDAE04C" modified="2014-10-01" version="1">MQPTGGQEQVLPNGGEEEPPRCNGPEAEQEALPNTAREDPPEREQSEVAAPVDEVPEVTGSHGPVNGAASGALVNGFRKPVITRVDDRVRINITRSRSKDEMRKLKRKLESELDQVRTLVGKVEAKEHQLTAYSTSNVNTNSRYVGGSVGNFGGYNQPQLLRANSEVGTLGHQYSRPQLLRVNSEAGSGGYQETRPFRHLNVSVMENNHGAAEFVEKEKRTPKANQYYRNSEFLLGKDRLPPESNKKLKLTAKKHGGDSEYGYGFGFDRNRDKVFKSCSNLLQRLMKHKHAWVFNEPVDAKKLNIPDYHIIIKHPMDFGTIKTRLGQNWYKSAREFAEDVRLVFRNAMTYNPKGQDVHTMAEELSKIFEDRWIAIEKEHFPYQMYYDAGLPIPTPRKAPPPSFTHIPAPILAPFSIPPAPPMRTLDRSESMTVPVDSRLKPTYSNLPHTGRTPVPKKPKAKDPNKRDMTYEEKQKLSTNLQSLPSEKLDAIVQIIKKRNTTLSQHDDEIEVDIDSVDAETLWELDRFVTNYKKSLSKNKRKAELALKRRAEAAQAVPTTNPIPAVVEPQKESKGDEKNSSPVVEVEKQGDNASGSSSSSSSSSDSGSTSSDSDSDSSSAYGSDAGHSPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDH5</accession>
    <name>A0A068VDH5_COFCA</name>
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        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">GSCOC_T00005552001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="gene ID" value="GSCOC_T00005552001"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="WBP2-like"/>
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        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CDP18781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12329" checksum="7CC4EC99815D46C1" modified="2014-10-01" version="1">MALKPLVFPSRMPLPFLNEVFVLARHGVEFEVDKIPGAQGGHVKAKGIIYLSNIRMVFVANKPVEDFAVFDLPLVSWLCTFCSARHSSLSYSLKRLVVNKVTIPTARGLCI</sequence>
</entry>
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    <name>A0A068VGL7_COFCA</name>
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        <submittedName>
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        <lineage>
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            <taxon>Coffea</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
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                <person name="Rouard M."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP19717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGL7"/>
    <dbReference type="Gramene" id="CDP19717">
        <property type="protein sequence ID" value="CDP19717"/>
        <property type="gene ID" value="GSCOC_T00007743001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGL7"/>
    <dbReference type="OMA" id="DVWDRWN"/>
    <dbReference type="OrthoDB" id="1689146at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025315">
        <property type="entry name" value="DUF4220"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007658">
        <property type="entry name" value="DUF594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31325">
        <property type="entry name" value="OS01G0798800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13968">
        <property type="entry name" value="DUF4220"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04578">
        <property type="entry name" value="DUF594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4220" evidence="2">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4220" evidence="2">
        <location>
            <begin position="130"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="549" mass="62860" checksum="51C8D013CE7C6B37" modified="2014-10-01" version="1">MELPNFDYWKQLWDKWELRAFIVISLSLQTFLILFAPLRKRASTGFLIMAVWSAYLLADSAAIFAVGLISNSQGNSRPHKDRDDDADLLAFWAPFLLVHLGGPDTITAFALEDNELWLRHLLGLVFHLGRFKDSMLTEPDPGPDYAKLMDEYYSKKEAKLPTRIQMIGESGRGNKASRVKEGPLTDLDVVLYAHQFFRTFRGLFVDLIFSFRERNQSRDFFLKRTADDAFRVLEVELNFYYDVFFTKVSVMYTNLGCIGRFVSVVCTVVALGLFYSERKKRKFNGFDVGITYTLLYGAIALDVIAIIMLIFSDSAVEKFIGYIGLANILNQMKYVKTVPFSTELRDLIFRELKKKSDMADDLDTAKDISSARGDWILRLEGFGELLPYISQMDYDQSLLLWHIATELCYSDEAKASSPNKDRDFSKLLSDYMLYLLVMQPTMMSAVTGIGQIRFRDTCAEVKKFRGKLKKKKEEPNVIQVIYKWEIMSKVWVELLSYAAIHCRASAHAQQLSKGGELITFVWLLMAHFGLGDQFQISEGHARAKLIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGS4</accession>
    <name>A0A068VGS4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_787</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00009569001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739871">
        <property type="protein sequence ID" value="CDP19921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGS4"/>
    <dbReference type="Gramene" id="CDP19921">
        <property type="protein sequence ID" value="CDP19921"/>
        <property type="gene ID" value="GSCOC_T00009569001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGS4"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGS4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF860">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP19921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="291" mass="32713" checksum="42D38B6A3292FC63" modified="2014-10-01" version="1">MDNSNAKNIANHSTVDSDRFKELKAFDDGKAGVKGLVDAGITNLPRIFIRPPEELIEEKNIGHLQVQVPVIDFSGIQGGDKSNSVIDEIRQASEEWGFFQEINHGVPQSLLDEMIDGAHRFHEQDAEVKKQYYSRDLLRMVRYFSNGDLFESSTANWNDCLAIKLTASNQAEPDELPEVCRSPVIDYASHWADVPLIPGSLTVNIGDLLQIISNDRFKSAEHRVIANRIGPRVSVPCFFGGVSTPARKYGPLKELISEESPALYKEFTVPEYAQNFFSMPYDGSHRDIWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGY5</accession>
    <name>A0A068VGY5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00010504001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739812">
        <property type="protein sequence ID" value="CDP19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGY5"/>
    <dbReference type="STRING" id="49390.A0A068VGY5"/>
    <dbReference type="Gramene" id="CDP19852">
        <property type="protein sequence ID" value="CDP19852"/>
        <property type="gene ID" value="GSCOC_T00010504001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGY5"/>
    <dbReference type="OrthoDB" id="1743670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGY5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="121" mass="13911" checksum="60813CF49AC9546B" modified="2014-10-01" version="1">MAWDVLRRTFLWEKVQPYLEETAFDEKPARRNTVPSAPEINLEATPSRARNRMITRKCTNLSHLLTLRSQGTKMGCRLAAPSVENVHGKVVGRSAARHQKSDAEHHIFVNIIWHLLILDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH09</accession>
    <name>A0A068VH09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">GSCOC_T00008959001</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 29">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 29">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="HG739406">
        <property type="protein sequence ID" value="CDP18968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH09"/>
    <dbReference type="STRING" id="49390.A0A068VH09"/>
    <dbReference type="Gramene" id="CDP18968">
        <property type="protein sequence ID" value="CDP18968"/>
        <property type="gene ID" value="GSCOC_T00008959001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH09"/>
    <dbReference type="OMA" id="HEDETQC"/>
    <dbReference type="PhylomeDB" id="A0A068VH09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF602">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 25" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658645" description="non-specific serine/threonine protein kinase" evidence="25">
        <location>
            <begin position="24"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="337"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CDP18968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="622" mass="69769" checksum="DB393FAC96849EE8" modified="2014-10-01" version="1">MQTTYFLFVGALVLLHFIVTGSATIIVANNQNNTVDLNALLAFKAAIFDPQRIIPTNWSTSTSVCNWIGITCNARHHRVAAIDLSYMGNAGTIPPQLGNLSFLVRFNVMNNSFHGHLPTELSRLRRLKYISLEGNYLTGSLPADIGYFKALVYLNLSNNQYLGGIPSTIGALQDLQELSFERNKLQGLIPDSMKNMLQLRHLDLSFNHLEGEIPNSLQVLSNLQYFNVSYNRLRGPIPHGGPFANFTNLSFLSNEALCGTPWLQPCTSTFEHESRKKRIVMIVLLASGSIILALVISIFLMRLKLRKKILAPTQNLRPMATFERASFHELRQITNGFSESNLLGSGSFGSVYKGIRENGMVWAIKVFDLQLEGAFKSFDRECEILSCLRHRNLTRVITACSNLDFKALVLEYMPNGSLEKWLHVNHHVLSIMQRLDITIDVACGLEYLHYGYSTPIVHCDLKPSNILLDQDMVGHVCDFGIAKLLGDGESVVQTKTLATFGYIAPEYGLEGLVSTSCDVYSFGITLMETFTKRKPKDEMFTEELSLRRWVQDCLPDSVIQVIDVDLLHPEDGLVQKKINCISSVLQLGLSCTTDAPEERINMKEVLRALQKIKLQFIKDITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH37</accession>
    <name>A0A068VH37_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_762</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00008707001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739846">
        <property type="protein sequence ID" value="CDP19884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068VH37"/>
    <dbReference type="Gramene" id="CDP19884">
        <property type="protein sequence ID" value="CDP19884"/>
        <property type="gene ID" value="GSCOC_T00008707001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH37"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH37"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="133" mass="14930" checksum="77ABF7B0FE6A5AB2" modified="2014-10-01" version="1">MLIGNFDSFLSKIGLAAIPFWLYLSSDLEMRAVLRSIKQFRSASRGRATYSLHQYADICRCYYPSYLFSRGLHADATRVAIGEINGAGPLVEYERRVTSGELVDGDVCQLGTLRELQRLCEQLVENADACQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIZ2</accession>
    <name>A0A068VIZ2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_1399</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00008869001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740483">
        <property type="protein sequence ID" value="CDP20587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIZ2"/>
    <dbReference type="Gramene" id="CDP20587">
        <property type="protein sequence ID" value="CDP20587"/>
        <property type="gene ID" value="GSCOC_T00008869001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIZ2"/>
    <dbReference type="PhylomeDB" id="A0A068VIZ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF3">
        <property type="entry name" value="OS09G0267800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="7">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="8">
        <location>
            <begin position="368"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="657" mass="74358" checksum="804E27BCDE13D2D4" modified="2014-10-01" version="1">MAIFLFPITLYFPDNQSDSFRLKGSSIYLGKLSGDECWSIIKGKVMSAGKEVVLGTLISIAADRIGMVRGFKADLIGGLLHTNRREKWHSIVQESLLNDQSQINQILKVSFDHLSSPSVKKCFAYCSIFPQDTELGEDELIEHWVAEGFVLPDRENTGMMEERGGEYLRILLQSSLLEKVGDEGSTWGTYYKMHDLVHDFAKSILNPESSSQDRYLALNSSEGLAENTTRTIPASIRTLFLHLEGGISVDMLLRFKYLHVLRLYGDDVKFLPSSIGKLPSLLLLDIKSSRIRSLPESLCKLYNLQTLTMRDDALEGGFPKRMSDLISLRHLNYHHGDAELKMPVQMGLLTCLQTLKFFNVSQEKGRGIEELGTLKYLKGSLEIRNLGLVKGKEAANQAKLFEKPDLSRLVFEWKRGDRNNCEEDVLEGLQPHPNLQKLEIDSFMGNKFPQWIINLPKLVTLWIENCHRCSELPSLGQLPSLKRLYLNRLYLIRSVGDEFYASGSSTRRQKFFPALEELCVEHMGNLVEWEGLTTISDKMFQSCRSLRSLSVERCPNLVSFSLNLQETPSLEEFGLVDCPKLIPHSFKGFAFATSLRRLSINSPFSSDDSPVDDFDWLASHGVPATPASILDYPHFTKSSQLWRNRSATGLDWKPCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ19</accession>
    <name>A0A068VJ19_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_1434</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00006435001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740518">
        <property type="protein sequence ID" value="CDP20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ19"/>
    <dbReference type="STRING" id="49390.A0A068VJ19"/>
    <dbReference type="Gramene" id="CDP20617">
        <property type="protein sequence ID" value="CDP20617"/>
        <property type="gene ID" value="GSCOC_T00006435001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ19"/>
    <dbReference type="OMA" id="GQTNPEM"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ19"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052650">
        <property type="entry name" value="Zinc_finger_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36886">
        <property type="entry name" value="PROTEIN FRIGIDA-ESSENTIAL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36886:SF8">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="895" mass="100712" checksum="840FE90A2CD6105A" modified="2014-10-01" version="1">MDERGRKRKPLWDAEDENQTISCSGKEYYSTYDGGRSNRFSSSKADNSSSMPKDHAGWPSWDTLEENTTGKKVEGVYKNEQDELEMRERVVSPGFDGWGHRKHSNSSDDSLSRSRRYLEGGRNRSRDRGRNRSRSPSWSKGRDRSGVRSRTMSRSRSRSRNRNRNSARGQTRSRSPFHGHRHDLQGWNDSSGSGRSSQTCRNFATGNCRRGNQCRFLHPDRMDRDYLENDFVERSRSRPDRGHALAYGEGRGRQSWDKGSDSNHQEDDSFRSKSRGTICCKDFMRGKCKWGASCRFSHHVDSGDNNGKDTRIALFERDREHRTNESRKPLCKYFLAGKCHRDNCWFSHDGPIDSNHESRPRDAGGRQSLVDKNDQWKGATWDQGEPESKAVEGSRWSETVVPNRKIADAPLERRDNKWAHERSLRSPELKEKASEGNNYLSTQDWSEDNGGDAGAIKSVVVESSYDRQEYPLISKGNLDLVYTGSHAPNITKKPSSQHLSEASLHAGLAEKSDILHHPTVAEDNIVNASSFDGLGQLKDNRNTNNPEFMPGQSLNQNVIGNLSLNHPLVSNDQRDNLFFPHPSNVRNVDLNGSGQGLSSTLIIQNHAGSHQKEAAKTPEIQEFGAPRSFYNNASNNQVPQNLLSPAAASPMHKFVAEQTQTHLHAALNHLTSTALVSALETAMQIQPNTDVRSPVQLDPLGDGRGKLGNVNQTSGEVPYSYEQKNGIPFEEFSPMSGDNPQFGNTLISNISNVQCHESPESKQQEAPAASEVKDNNTESVVECQKGQEDLHKENGDEHVKVGNGNNNKDDKDMRLFKNALVDFVKETLKPTWKEGRMSREVHKTIVKKVVDKVTSTMQDHIPKTQGKTDQYLSHSKPKITKLVQAYVERHLKTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJG1</accession>
    <name>A0A068VJG1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_1544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00013534001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740628">
        <property type="protein sequence ID" value="CDP20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJG1"/>
    <dbReference type="STRING" id="49390.A0A068VJG1"/>
    <dbReference type="Gramene" id="CDP20684">
        <property type="protein sequence ID" value="CDP20684"/>
        <property type="gene ID" value="GSCOC_T00013534001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJG1"/>
    <dbReference type="OMA" id="ENQRRKW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000037">
        <property type="entry name" value="Heat stress transcription factor B-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF322">
        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR A-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="209" mass="23736" checksum="5C924B504B682FA3" modified="2014-10-01" version="1">MGTDVSESNSNAIVTAAAAVSATPLAKEGYANGASSSSSRVRAPPPFLLKVYDIVKNPETESIISWSSSGTSFIVWDPHRFAAEVLGKYFRHNNFASFICQLNTYGFRKINWDRLEFQNAWFQKGKKSWLKKIKRRIQGTQNAHLCKLLGTEGQLSLSGEQKKFESLMQEHDALKVEIMKLKDREENQRRKWKSLRKKPSVLHPSCKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJP7</accession>
    <name>A0A068VJP7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00009974001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="5"/>
    <dbReference type="EMBL" id="HG739850">
        <property type="protein sequence ID" value="CDP19898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJP7"/>
    <dbReference type="FunCoup" id="A0A068VJP7">
        <property type="interactions" value="3091"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJP7"/>
    <dbReference type="Gramene" id="CDP19898">
        <property type="protein sequence ID" value="CDP19898"/>
        <property type="gene ID" value="GSCOC_T00009974001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJP7"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000009">
        <property type="entry name" value="mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000002">
        <property type="entry name" value="Mannosyl-oligosaccharide glucosidase GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF20">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="7">
        <location>
            <begin position="347"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP19898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="849" mass="97292" checksum="A753DF317A1F96BB" modified="2014-10-01" version="1">MAGSSRRSSTRSRGKPSADAVGDESVHRVSTNARPRSYRGRDQSLIRITNVSSKVFLGFGILFSSIALFLIFRLVNTNEEPEKPRVITPFPAPKLMELPMFQGEHKESLYWGTYRPNVYFGIRARTPQSLIAGLMWIGITNGRYAMRHICQDSDELRTYGWTEHNGRDYGHQILVDQDMTLKTSFLKSKEHGSSYGGDWAVRIEVENDEVNLSEEMSKTVHLFFYMDDESGNALNLGSGATDVDDESILASGYRSDVGNWQLLLSTEDEFEFHYSGFKTPFVHNLSDLVQSNLGIQARKVGRLQLSDTSEGSSNILVFQLSGRIPFKADIIFQSGTLAQKERAIGLAGASLTNKLSEKQKDYADKFERCFNLGDELDSGSVTVGKAALANLLGGIGYFYGQSQIALSNRPDKKHGDDFISYWPAELYTAVPSRPFFPRGFLWDEGFHQLLIWRWDIHICLDIIGHWLDLMNIDGWIPREQILGAEALSKVPEEFVTQHPTNGNPPTLFLVLRDLICSIKAKKFAAGERKEISIFFDEAFVRLEGWFKWFNTTQSGKAVSSYFWHGRDNKTIRELNPKTLSSGLDDYPRASHPSEDERHLDIRCWMHLAADCLHSILEFLEKENEHGKEYRSTAKLLSDFQLLNEMHFDDAYGAYFDYGNHTENVRLSWQVVETVNGHPNRELIREVLEKPVLRLVPHVGYVSLFPLMERLIPPGSWILEKQLDLISNRSTLWTNFGLRSLSKTSSIYMKRNTEHDPPYWRGPIWMNMNYRILSALHYYSREDGPYRQRAKAIYDDLRNNLIRNVVKNYHQTGYLWEQYDQQKGKGKGARVFTGWTSLVVLIMAEKYNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKD2</accession>
    <name>A0A068VKD2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_2961</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00010796001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG742045">
        <property type="protein sequence ID" value="CDP21245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKD2"/>
    <dbReference type="STRING" id="49390.A0A068VKD2"/>
    <dbReference type="Gramene" id="CDP21245">
        <property type="protein sequence ID" value="CDP21245"/>
        <property type="gene ID" value="GSCOC_T00010796001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKD2"/>
    <dbReference type="PhylomeDB" id="A0A068VKD2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP21245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="334" mass="37590" checksum="8D2B2BFD9490534F" modified="2014-10-01" version="1">MPQVYAMNGGNGPQSYNQNSSFQRGAVDVAKELIKEEIDKELDVKQLSSTSVHPFRIADFGCSTGPNTFVAMKAIREALEEKLRKEGLASEVPEFEVFFNDHISNDFNTLFASLPPERHYLAAGVPGDFHKVLLPKATLHFAHSSCSLHWLSDVPKEVTDNTSPAWNKGKIHHGGAKKKVLEAYASQFAKDLDLSSNFDYRFWLTKKKSTLNTKMHLLQGLVDELKVDMFNLPLYLPSPNEIKTLMKANEHLNVQRLEILSIPGKHVVFSNPSGIVLYLRAALEGLLEKQFGSDIMDELFELFTQKLAESSSLFNPENQDLAVIFVLLKRKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLG9</accession>
    <name>A0A068VLG9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_4766</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00009574001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743850">
        <property type="protein sequence ID" value="CDP21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLG9"/>
    <dbReference type="Gramene" id="CDP21546">
        <property type="protein sequence ID" value="CDP21546"/>
        <property type="gene ID" value="GSCOC_T00009574001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLG9"/>
    <dbReference type="OMA" id="CETICAC"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLG9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="173"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="325" mass="36444" checksum="968511AB7729A8C2" modified="2014-10-01" version="1">MQTNNPQVCDSQTQKSKTIPVIYFTTENLKLGTSSWLSTCKAVREALEDFGCFIAVYDKAESECKIDVFASLKEFFNLPMETKLLNVHPDKDAFGYFGPKPNFPLLEAISIEDSTTIEAVQSFANLAWPSGNDHFCETICACTRQLSEVNRMVSKMIFESYGVGRYSDSHIESTSYLFRANAYRVSQEKEPNLGISPHTDTSFVSVLKQDSVQGLQIQSKDGTWIPVDFPPSSVAIMAGDAMLAWSNGRVRPCFHRVMVTEKARTSIGLFSFHTGIVQVPKELADDNYPSQFTSFDHWGLLKFRSKNPALSSNERVKAYCGRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLV4</accession>
    <name>A0A068VLV4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00010866001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HG740580">
        <property type="protein sequence ID" value="CDP20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLV4"/>
    <dbReference type="STRING" id="49390.A0A068VLV4"/>
    <dbReference type="Gramene" id="CDP20658">
        <property type="protein sequence ID" value="CDP20658"/>
        <property type="gene ID" value="GSCOC_T00010866001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLV4"/>
    <dbReference type="OMA" id="FWNLHEL"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLV4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656074" description="beta-galactosidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="5">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="113" mass="12946" checksum="862EF668D491C31A" modified="2014-10-01" version="1">MVLFLFIIVFLSAVLALFAANVTFDHCTLVIDGRRKVLISVTIHSCLGREHFQMYTYLTVKSKYGGLDAIETYVFWNLHELVRGQVSSFWLSFQLCFASVEILCCSHYKKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TL61</accession>
    <name>A0A068TL61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014299001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TL61"/>
    <dbReference type="FunCoup" id="A0A068TL61">
        <property type="interactions" value="1361"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TL61"/>
    <dbReference type="Gramene" id="CDO97070">
        <property type="protein sequence ID" value="CDO97070"/>
        <property type="gene ID" value="GSCOC_T00014299001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TL61"/>
    <dbReference type="OMA" id="ADMDRDK"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TL61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009532">
        <property type="term" value="C:plastid stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000035">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF8">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="35942" checksum="8A009A21AE88D3D6" modified="2014-10-01" version="1">MSPLPFVYLRRCPVLSLITSYPLSNLVEAAVVRSPVSSAASRSCIDTDCESIIRKMVASTIAAPFCSPRVSYPPRTTPYLAASSLDGNQKRSLPSALPNPRADLSAIGLSSKTNGFLLKHEQNDPCAGSNSSYGPIEAKKGNPPIMPAVMTPGGPLDLCTVLFRNRIIFIGQPVTSQVAQQVISQLVTLATIDEDTDILMYLNCPGGSTYSVLAIYDCMSWIKPKVGTVCFGVAASQGALLLAGGEKGMRYAMPNARIMIHQPQSGCGGHVEDVRRQVNEAVQSRHKIDRMYASFTGQPLEKVQQYTERDRFLSVSEAMEFGLIDGVLETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMS1</accession>
    <name>A0A068TMS1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress enhanced protein 1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014482001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMS1"/>
    <dbReference type="FunCoup" id="A0A068TMS1">
        <property type="interactions" value="1886"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMS1"/>
    <dbReference type="Gramene" id="CDO97214">
        <property type="protein sequence ID" value="CDO97214"/>
        <property type="gene ID" value="GSCOC_T00014482001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMS1"/>
    <dbReference type="OMA" id="VCKATTF"/>
    <dbReference type="OrthoDB" id="543868at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMS1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="14561" checksum="53DBE106CBF08FA9" modified="2014-10-01" version="1">MALAQVSNCLYTSVRDVCVSNPVRISSAARIPISGVAKFGTTFASGSPLPVQRSSYSTKAASKATSVSIKCEQGAKGGNSVDVWLGRFAMVGFAAAISVEIGTGKGLLENFGLTTPLPTVALAVTALVGVLTAVFIFQSASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP59</accession>
    <name>A0A068TP59_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00015092001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP59"/>
    <dbReference type="STRING" id="49390.A0A068TP59"/>
    <dbReference type="Gramene" id="CDO97684">
        <property type="protein sequence ID" value="CDO97684"/>
        <property type="gene ID" value="GSCOC_T00015092001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP59"/>
    <dbReference type="OMA" id="HVFWRYP"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP59"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001533">
        <property type="entry name" value="ABC transporter G family member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF4">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="66"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO97684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="675" mass="75387" checksum="7B03DC9023967AEC" modified="2014-10-01" version="1">MASPNLTPPPRLSHDDYDDELMNSPHTNVSEIKIPLDQVDGDQEDGEENTGTDYGECNSNSKGVFLTWDDLWVSVPNGKKGCKAILQGLTGYARPGELLAIMGPSGCGKSTLLDALAGRLDTKSKQMGEILVNGRMQQLAYGTSAYVTQDNILTWTLTTREAVYYSAQLQLPNTMSKAEKIDRADRTIREMGLQSCIDTRIGGWGSKGLSGGQQKRVSICIEILTRPKLLFLDEPTSGLDSAASYYVMNRIAELAKEYGMTVVASMHQPSTEVCKLLDNLCLLSLGRTIYFGPSIAVNQFFARNGFLSPGLQNPVDHYLRMINTDFDEDIESAADGKTTTKEVIDKLVESYTSSDTYDLILREVAQINGQQIGVVEEKRRRGSFFIQCLVLTERSFVNMHRDLGYYWLRLAIYITLAFGLGTVFYNVGNSYTSINARASMLMFVASLLTLMSIGGFPSFVEEIKVFQRERLNGHYGVAAFVVSNTASSVLFLCLIAVIPGVIVYYLVGLQRGTERFLYFIMVLFASIMLVEGLMMIVASLVPNFLMGLIIGAGTQGVMMLSGGFFRLPHDLPSIFWKYPIYYTSFHRYAYQGLYKNEFEGLKFPSNELMKGGSSSIDGETILRHTWQVEMGYSKWIDLAVLFLMVILYRLLFFGIIKVGERIKPLVKRFYVGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ36</accession>
    <name>A0A068TQ36_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00022522001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
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            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="431" mass="48740" checksum="28A78D1D45B4CE00" modified="2014-10-01" version="1">MITEGKTANVLGGKTARACDSCLKKRARWFCAADDAFLCQACDTSVHSANQLASRHERIRLATSSFMPIETKGDENSLPTWHQGFTRKARTPRNNKASLVHQPKDEEKMAKANPLPLVPEISGDETSPDESEEQHLFCRVPVFDPFAAELCSELSDEVQNIQADKGTHDEILTSNELNVLLNDDQDLDIPELIASDAELAEFAADVESLLGTGLDEDSCHMEDPGMMVCKEEDDVVDVSFEDKLVKVEDEDDQEVQAVIACHLDPALDMARESLNWDFDSSSPVIEEEEELKVTKDMPDKDIKSKEEERRMMHLKLNYEEVITAWASQGSPWADGTKPEFNLGDCWPDFMGMSLNELHHPNGAGGGRVSSHDEEREARVTRYREKRRTRLFSKKIRYEVRKLNAEKRPRMKGRFVKRTSFAGPSFPYLMKK</sequence>
</entry>
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    <accession>A0A068TQC6</accession>
    <name>A0A068TQC6_COFCA</name>
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        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AA_transpt_TM"/>
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        <property type="match status" value="1"/>
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        </location>
    </feature>
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            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="476"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO98187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="486" mass="52834" checksum="C5237B2F89FC163D" modified="2014-10-01" version="1">MDSNYSAISKDSDVELKVKDHVLGSKDKSFRLISQDEELGYVKPDNVDDSEVRDDLDFDNFPLIIGEAKSGSGIYGAVFNLTTSIIGAGIMALPATMKVLGLVLGVVLILLMGILSEISVELLVRFAIHCKASSYGEVVQAALGRAARILSEICIIVNNAGVLVVYLIIMGDVLSGSIRHIGVFDQWLGHGMWDHRKLLVLVIVVIFLAPLCALDKIDSLSLTSAASVALAVVFVFVAFVVAFIKLVEGKIEAPRMAPDFGSKTAILDLLVVIPIMSNAYVCHFNVQPIYNELEGRSPSKMNRVGRITTVICVLVYASTAIAGYLLFGKDTEADVLTNFDKDLGIRFSTALNYIVRIGYIFHLILVFPVIHFSLRQTVDTMLFEGSAPLQESKKRCLALTLVLLGLIYFGSTMIPNIWTAFKFTGATTAVSLGYTFPALIALRLSKEGVSLSFAERLLSWFMLTLAIVVSVAGVIGNVYSIKSQSE</sequence>
</entry>
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    <accession>A0A068TSD0</accession>
    <name>A0A068TSD0_COFCA</name>
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        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025950001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSD0"/>
    <dbReference type="FunCoup" id="A0A068TSD0">
        <property type="interactions" value="2443"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSD0"/>
    <dbReference type="Gramene" id="CDO98962">
        <property type="protein sequence ID" value="CDO98962"/>
        <property type="gene ID" value="GSCOC_T00025950001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSD0"/>
    <dbReference type="OMA" id="SYHPCAQ"/>
    <dbReference type="OrthoDB" id="1877176at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSD0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09256">
        <property type="entry name" value="AP_MuD_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000027">
        <property type="entry name" value="Adaptor complexes medium subunit family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000025">
        <property type="entry name" value="AP-5 complex subunit mu isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039591">
        <property type="entry name" value="AP5M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16082">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT MU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16082:SF2">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT MU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="311"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="626" mass="67796" checksum="CA555D0C8724A083" modified="2014-10-01" version="1">MAGGCSIRAIWILSSQDAVVYSRRFPVVERRWRLACDKESQSAGATDSLKVVPYLPTDSELAAAFIDRKRREGSVRGFGIRTSHSVKGSDSWVDDPITRHIISLSIDKEEQGESHFIWPVILHVKGPFYLLALPLVEPHHLKTYARMCNRSDCGNTIGEDENLSSLLLDLPSITGAFMVVHTIGDIVTGDITEPEVVASASPSVGGLLDSLTGSIGISGRAKPVATPIAASATSSTSVSGTLASDAPKIGSRSLDKDALQSFISSAMPFGTPMDLSYSNISAMKMNGFSSVDVPSADSKQPAWKPYLYRGKQRILFTIHETVHVAMYDRDEIPDSITASGQVNCRAELEGLPDVSFPLTGLGSAHVELLSFHPCAQVPEHGGDKHAVTFSPPLGNFLLMRYQVSDGIRPPVKGFYQLSMVSENEGAFLFKLRLMEGYKTPLSLEFCTVTMLFPRRMVASCDGTPSIGTVFSTERSVEWRIITSGRGVSGKSIEATFSGTLKFVPWQTKKPPSSGSVFGSIDDEDSDFETDSPNNIVNVEDFLAEKMSKDLQAVDLEEPFCWQAYSYAKVSFKMVGSTLSGMSIDPKSVSIFPAVKAPVELSAQVTSGEYILWNTLGKCPVAATPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSG1</accession>
    <name>A0A068TSG1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00026267001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSG1"/>
    <dbReference type="STRING" id="49390.A0A068TSG1"/>
    <dbReference type="Gramene" id="CDO99200">
        <property type="protein sequence ID" value="CDO99200"/>
        <property type="gene ID" value="GSCOC_T00026267001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSG1"/>
    <dbReference type="OMA" id="VRDYVIY"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSG1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000005">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF859">
        <property type="entry name" value="OS03G0690500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO99200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="262" mass="29377" checksum="96B1FF545DF2077F" modified="2014-10-01" version="1">MLDGVRRFYDQDTEVKKRWYTRDGSKTVVYNSNFDLFSAPSANWRDTSYVNMAPKVPRADELPEACSDILIKYSGYIKKLGRSLFELLSEALGLKPNHLNDIGCSEGLAVLYHCYPACPEPELTLGATKHADYDFMTVLLQDHTGGLQILYENQWVDVPPVPGALVVNVGDLLQARYQSLISNDKFNSSQHRVLANRAGPRVSVACFFTTGLAPSSKRYGPIKELLSEDNPPRYRETTVKDYSLHYNAKGLGTTSALLDFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTE3</accession>
    <name>A0A068TTE3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026421001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTE3"/>
    <dbReference type="FunCoup" id="A0A068TTE3">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTE3"/>
    <dbReference type="Gramene" id="CDO99312">
        <property type="protein sequence ID" value="CDO99312"/>
        <property type="gene ID" value="GSCOC_T00026421001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTE3"/>
    <dbReference type="OMA" id="MIFIDAY"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTE3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000351">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF56">
        <property type="entry name" value="OS04G0510700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46982" checksum="5F6057852772E6E0" modified="2014-10-01" version="1">MINKVKSSLSSNLRRFSTAIRRHIEDEGDWFYSSEWWGTDSGSDGQTVFRVVSDKGNGVVSVLAYPSSKPDNIHWHKTESWLQQRFAEIHPFCENNGFKVIGYQWRTLHFNDDTRQSTVKIMAAYEKSDPASVFYMQQPHCLAVPYVKSMISAGLVTISSCNFDLNSAICGKKIMNVLCIGHGGGSIPLFMASKIEGAVVHIVEIDPLVISASTQAMGFPPFAVMTMSGERACPEPDPVNEVLWKGIHERLLLYRSDAEKFISETTTLYDIVFIDAYDGDDIFPHKLWDPHSPFLKTLANKLHPEHGTVVLNLHSDTDLSVDTSVSPVFSVLPMGKYVFSVCRAYKDVLLGDSSLHGGVAYTVSVPWVCNTSLVVSRGFGKAYSRNMVFNSLMSSSLQVENILQLPFSCVQYIKRGFTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTI1</accession>
    <name>A0A068TTI1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3700 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029199001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTI1"/>
    <dbReference type="STRING" id="49390.A0A068TTI1"/>
    <dbReference type="Gramene" id="CDO99566">
        <property type="protein sequence ID" value="CDO99566"/>
        <property type="gene ID" value="GSCOC_T00029199001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTI1"/>
    <dbReference type="OMA" id="WATWGPS"/>
    <dbReference type="OrthoDB" id="2019121at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024286">
        <property type="entry name" value="DUF3700"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044828">
        <property type="entry name" value="TSJT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45952">
        <property type="entry name" value="ALUMINUM INDUCED PROTEIN WITH YGL AND LRDR MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45952:SF6">
        <property type="entry name" value="STEM-SPECIFIC PROTEIN TSJT1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12481">
        <property type="entry name" value="DUF3700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01172">
        <property type="entry name" value="DUF3700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3700" evidence="1">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="259" mass="28376" checksum="2B714EC512445D86" modified="2014-10-01" version="1">MLAIFKNGLVVPPQELKSPASSTHAPAFDNAKNLEETLKDFLSSHSNNGFSLGFADNALLAYAPPQRSHITAHQRMFCGVNDIYCVFTGSLRNLPTLIKQYGLSKGVNEAMFIVEAYRTLRDRSPYPAHQVLKDLDGSFGFVIYDDKARTAFAALGADEVVKLYWGIAANGSLMISDDVNLVKASCAKSFAPFPTGCMFHSERGLMSFEHPMHKMKAMPRVDSEGVMCGSNFKVDALSKINSIPRVGSEANWATWGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUU2</accession>
    <name>A0A068TUU2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029854001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUU2"/>
    <dbReference type="STRING" id="49390.A0A068TUU2"/>
    <dbReference type="Gramene" id="CDP00070">
        <property type="protein sequence ID" value="CDP00070"/>
        <property type="gene ID" value="GSCOC_T00029854001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUU2"/>
    <dbReference type="OMA" id="MDYPERW"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUU2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47041:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL_PHOSPHATIDYLCHOLINE TRANSFER PROTEIN SFH12-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47041">
        <property type="entry name" value="SEC14 CYTOSOLIC FACTOR FAMILY PROTEIN / PHOSPHOGLYCERIDE TRANSFER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="224"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="467" mass="52934" checksum="38C1B4B8EFBE7C32" modified="2014-10-01" version="1">MGDSLRASNSDRILEARRAICSKRQSITYSAFAASKVLSQKALKCITSVKQQIQGSGVAGDIMVFLVTTAALEVVRRFSKAKCPFVWRALQALQILCYPPFKWLQRWQPFKGLVKHSKKLSRPMLVLSISTLFSDQPGYSTESLNDSNEIQDASSQMPRPDTSSSAEWLLELRRELRKHGREVPERLGDDELHRYYAAVNGDFSKLVSSVKKTIDWRQSYKLFPPHELEAYSHLVFWHGHDSERRPCLIIRLGLACSNLQSDDRPLFIKAVVSQIEHGVLNLVTVDQPQIMVLMDCEGLSPFGFPIHMMRSCATLLQDHYPNRLGSLIIIRLPQLARVITQALFQVLKPATQRKVRTVGGNYQEILCQCLRPIPSFLGGNCSCSRCSDPRRVQDRDEGSALMPPEAELVANNSLDMHLPAPTDTTEDRNQLKRTVVMVLLMLLMLILVILEKLYPEKLSLLYQQMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TV22</accession>
    <name>A0A068TV22_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00029607001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TV22"/>
    <dbReference type="FunCoup" id="A0A068TV22">
        <property type="interactions" value="2715"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TV22"/>
    <dbReference type="MEROPS" id="M18.A02"/>
    <dbReference type="Gramene" id="CDO99897">
        <property type="protein sequence ID" value="CDO99897"/>
        <property type="gene ID" value="GSCOC_T00029607001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TV22"/>
    <dbReference type="OMA" id="LLDTHYY"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TV22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO99897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="546" mass="60254" checksum="1647D2265611994E" modified="2014-10-01" version="1">MPTAAAIARFQVQVLHPSPFFKPSTLFSKFPRSSLPIPSTLKRSNTRFRRLSSLTPPLCSSSSHSSSAGGSLESHSSSESGGSVVGDLLDYLNESWTQFHATAEAKRQLLAAGFHLLNENDEWDLKPGGRYFFTRNMSSLVAFAIGEKYSNGNGFHIIAAHTDSPCLKLKPNSASSKSGYLMVNVQTYGSGLWHTWFDRDLSVAGRVIVRADNGCFLHKLVKIKRPILRVPTLAIHLDRTVNKDGFKPNLETHLIPLLAKKVDNASAETKDKINMPSSKDAHHQQLLQILSDELACNIDDIISIELNVCDTQPSCLGGVNNEFIFSGRLDNLASSFCALRALVDSCASPKDLSDERAIRMVALFDNEEVGSDSYQGAGAPTMFEAMRRITDCLDLHSVRESSFARAIRCSFLVSADMAHGVHPNFMDKHEEHHRPELQKGLVIKHNANQRYATSGVTAFLFKEVAKMNNLPTQEFVVRNDMGCGSTIGPILASGVGIRTVDCGIAQLSMHSVREICGKEDVDFAYKHFRAFYQTFSSIDRKLNVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWB1</accession>
    <name>A0A068TWB1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00032525001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWB1"/>
    <dbReference type="FunCoup" id="A0A068TWB1">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWB1"/>
    <dbReference type="Gramene" id="CDP00551">
        <property type="protein sequence ID" value="CDP00551"/>
        <property type="gene ID" value="GSCOC_T00032525001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWB1"/>
    <dbReference type="OMA" id="VEEIPGC"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWB1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000337">
        <property type="entry name" value="ABC transporter G family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF24">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="71"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="678" mass="75425" checksum="421BC261DE55D40C" modified="2014-10-01" version="1">MMPPEQKNSSASMAGCAGPASNMIKCSRAENNSVHVEPLNSATNVNQSPDENQTSPVRYSILRQSLRPVTLKFEDVAYTLSLRGTGGGCFSSSHPKPTRAILNGVSGIVRPGELLAMLGPSGSGKTTLLTALAGRLSGKVSGTITYNGLPFSSSMKRKTGFVSQDDVLYAHLTVLETLTYTAFLRLPNKLSRNEKIEQVELIIMELGLNRCRNGMIGGPLLRGVSGGERKRVTIGQEMLVNPSLLLLDEPTSGLDSTTAQRIIATLRWLARGGRTVITTLHQPSSRMYTMFDKVLVLSEGYPIYSGSASLVMEYFASIGYMPGFNFVNPADFLLDLANGVVLGTRQDDRTEFPGRPDHHDEKSSIRQFLVSSYKKILYPSLKDEMQRRSQDPVNSRGATGSKSSENQWTTTWWLQFKVLLSRGLKERKHESYSGLRIFQVMSVSILSGLLWWHSGTIHIQDQVGLLFFFSIFWGFFPMFNAVFAFPQEQPMLTRERSSGMYRLSSYYFARTVGDLPMELVLPTIFVIVTYWMSGLKPSLVTFVLTLLIILFNVLVSQGFGLALGAILMDLKQATTLSSVMMLVFLLASGYYIRHIPPFIAWLKYISFSHYSYKLLLAVQYSNNELYQCGVGVHCRVMDNPAIKFLGIENLGMDVAALAVMLIGYRLLAYIALRLRQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX43</accession>
    <name>A0A068TX43_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00034295001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX43"/>
    <dbReference type="FunCoup" id="A0A068TX43">
        <property type="interactions" value="1622"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TX43"/>
    <dbReference type="Gramene" id="CDP00865">
        <property type="protein sequence ID" value="CDP00865"/>
        <property type="gene ID" value="GSCOC_T00034295001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX43"/>
    <dbReference type="OMA" id="TDDQNIY"/>
    <dbReference type="OrthoDB" id="1910064at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43456">
        <property type="entry name" value="RIESKE (2FE-2S) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43456:SF2">
        <property type="entry name" value="RIESKE (2FE-2S) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="284" mass="30612" checksum="51FD5C84E96745EE" modified="2014-10-01" version="1">MAAGTAASKLTTAFLTVPSASHHHRHHGQPPLTTIKPPSFFKPKRLLSISRKATDVSSSSVQAEESSSAAAPKDNTENWVPVVPLAALPKGERRVIMQDGDTILLLWYKDEVFAIENRSPAEGAYTEGLLNAKLTQDGCIVCPTTDSTFDLQTGAIKEWYPNNPVLRVLTPALRNLFVYPVKVEGENIYISLKGGASDASAEIVFSGKAQPGVTATDVNVEEVRMVVDEELEGFGFTGTNELINGKAAIIGFLLLLDFELLTGKGLLKGTGFLDFIYSISNAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYB1</accession>
    <name>A0A068TYB1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00034548001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYB1"/>
    <dbReference type="STRING" id="49390.A0A068TYB1"/>
    <dbReference type="Gramene" id="CDP01052">
        <property type="protein sequence ID" value="CDP01052"/>
        <property type="gene ID" value="GSCOC_T00034548001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYB1"/>
    <dbReference type="OMA" id="LWSSDHV"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYB1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000016">
        <property type="entry name" value="Carbon catabolite repressor protein 4 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF79">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4 HOMOLOG 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="20">
        <location>
            <begin position="185"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP01052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="543" mass="62019" checksum="FB22D6607E38EB1D" modified="2014-10-01" version="1">MGLEWEVQVRFPSDTPVAGIELNPWVRVNYKGSYVSPPNYALQFAWYREFSTLPKCVEDYVAFQDHASRDSSMTIYGGGLNQEKHGLLKSEGLKIVDGEGKTWIQVGSSRTYTPSEDDINSSLRLVSVAIDDMGIKMSINVFVTTPVIRLPHPYPRHMIVFCSLRKLRNPKCIATPFKEESFRVLSYNILADLYTVSGAYTHCPNWALTWEYRRRNLLNEILSYDADILCLQEVQSDHFKNFFESEFAKVGYSAIYKRKTKEVYSANEYVIDGCATFFRHDRFKIVIKYEVEYDKMALPVIEVLEPDKRNDGLFRLMKDNVALVVILEEKDNGRSQDAARSTICVANTHIHRGSDASDVRLFQVVNLIRGLEKIDSSGIPILICGDMNSLPGSDPHRFLINGEVGCFSEKFRDPLGIHKHLKLSHSMHLACAYAHLLDSNEVGQHQKEKMGYQAMEPLFTCFKPSLTGTLDYILYSKNRLKVDGLLKLLDYDSLEKRLLPSPLWSSDHVALMANFRVKRASRGVQYLSPPPDPWEQQNKQTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYT2</accession>
    <name>A0A068TYT2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL29c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">50S ribosomal protein L29, chloroplastic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">CL29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00036519001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYT2"/>
    <dbReference type="FunCoup" id="A0A068TYT2">
        <property type="interactions" value="1328"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYT2"/>
    <dbReference type="Gramene" id="CDP01465">
        <property type="protein sequence ID" value="CDP01465"/>
        <property type="gene ID" value="GSCOC_T00036519001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYT2"/>
    <dbReference type="OMA" id="SSFHGIK"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYT2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000004">
        <property type="entry name" value="50S ribosomal protein L29, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050063">
        <property type="entry name" value="Ribosomal_protein_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10916">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35/50S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10916:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP01465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="19534" checksum="A8F2A2A492555910" modified="2014-10-01" version="1">MMSLSIASPTSVSFTGKLGLSKSSFHGVRIAHICPALAPSASTLRTSSGSSSSASSRVVMMAKKQEELKEIRAKTTEELSEEIVDLKGELFMLRLQRSARNEFKSSEFRRMRKRIARMLTVKRERELEEGINKRLSRKLDKKWKKSIVPRPPPSLKKLQEEEAAAEAKEAKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYT9</accession>
    <name>A0A068TYT9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00036482001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="8"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYT9"/>
    <dbReference type="FunCoup" id="A0A068TYT9">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYT9"/>
    <dbReference type="Gramene" id="CDP01436">
        <property type="protein sequence ID" value="CDP01436"/>
        <property type="gene ID" value="GSCOC_T00036482001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYT9"/>
    <dbReference type="OMA" id="QRLVQWK"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYT9"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000073">
        <property type="entry name" value="Trehalose 6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000099">
        <property type="entry name" value="Trehalose 6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768:SF3">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="379" mass="42229" checksum="8A97DCC9D5774329" modified="2014-10-01" version="1">MTKQNVVVSGTKSGISMAIAVAVTNSALFTTASQKPPAVPGTYFSISKKKLLQNLEINTGAKINSWVDSMRASSPTHLKSTPPLSSDDQSSSTLHHPSALDMFEQITNASKGKQIVMFLDYDGTLSPIVEDPDRAFMSDAMRAAVRKLAGCFPTAIVSGRCRDKVYSFVRLAELYYAGSHGMDIKGPSKGSKHKKGAQAVLFQPDTANEFLPMIDEVYEALLEKTKSTEGAKVENNKFCVSVHFRCVDEKKWVELAQQVKSVLMDYPKLRLTQGRMVLEIRPTIKWDKGKALEFLLESLGYANRKDVFPVYIGDDRTDEDAFKVLKERRQGFGILVSKTPKETSASYSLQEPGEVMNFLQRLVQWKRRCLGEFEDSLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ41</accession>
    <name>A0A068TZ41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SKIP34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00036662001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ41"/>
    <dbReference type="FunCoup" id="A0A068TZ41">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP01570">
        <property type="protein sequence ID" value="CDP01570"/>
        <property type="gene ID" value="GSCOC_T00036662001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ41"/>
    <dbReference type="OMA" id="CVMEILE"/>
    <dbReference type="OrthoDB" id="1926663at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12289" checksum="C8ED51ECA3701517" modified="2014-10-01" version="1">MCYGGERLPSKEDFDVDGPTRPTAAAARLAAVNENEAVVENLRDRLAETEARLERARAREAALSRQLEEMKRFVSVMEILETYLKRRYREQQDQLCRLFSPVSAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZU2</accession>
    <name>A0A068TZU2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial adenine nucleotide transporter BTL3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00036512001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable mitochondrial adenylate carrier that catalyzes the transport of ATP, ADP and AMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZU2"/>
    <dbReference type="FunCoup" id="A0A068TZU2">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZU2"/>
    <dbReference type="Gramene" id="CDP01459">
        <property type="protein sequence ID" value="CDP01459"/>
        <property type="gene ID" value="GSCOC_T00036512001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZU2"/>
    <dbReference type="OMA" id="RHMIRTE"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZU2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000098">
        <property type="entry name" value="Mitochondrial substrate carrier family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="155"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="362"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP01459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49347" checksum="219C8D1CBD0E67AB" modified="2014-10-01" version="1">MTNLEVWLKNLVANSLESKQVQYLAEAHDFSLHLNGFIGGGLFLEPSIPSSFVSLVNPNNSSNSLSLVGVSCSGDRRSRRRSRRRGIVACGGSGRGRFLSVTLSTVKGGEGGEGIGEVLLQDAGKSVECETPAFEEGEKKKEGESKVREVKGKALNTVKHLWAGAVAAMVSRTFVAPLERLKLEYIVRGEQKNLFELIKTIAATQGLKGFWKGNFVNILRTAPFKAVNFYAYDTYRNQLLRMSGNEETTHFERFVAGAAAGITATVLCIPMDTIRTVMVAPGGEALGGVIGAFRHMIQTEGFFSLYKGLLPSIISMAPSGAVFYGVYDILKSAYLHSPEGRKRLQHMKQQGEELNALEQLELGPVRTLIYGAIAGACSEAVTYPFEVVRRQLQMQVRATKMSALGTCMKIVEQGGIPALYAGLIPSLLQVLPSAAISYFVYEFMKIVLEVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0A9</accession>
    <name>A0A068U0A9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Morc S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00037145001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MORC ATPase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0A9"/>
    <dbReference type="FunCoup" id="A0A068U0A9">
        <property type="interactions" value="2104"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP01951">
        <property type="protein sequence ID" value="CDP01951"/>
        <property type="gene ID" value="GSCOC_T00037145001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0A9"/>
    <dbReference type="OMA" id="RHPETIM"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0A9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000075">
        <property type="entry name" value="MORC family CW-type zinc finger protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045261">
        <property type="entry name" value="MORC_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336:SF50">
        <property type="entry name" value="PROTEIN MICRORCHIDIA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Morc S5" evidence="16">
        <location>
            <begin position="344"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP01951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="621" mass="70533" checksum="819F5991314916CE" modified="2014-10-01" version="1">MKAPVDVVEIHSSDDEATIVVDAGGHRNLNNSNNNIYKPINDAQLQLRAPKLENPVVLAPPDSNYQPLDTRSFWKAGAYEIGPSKCSYIQGDLEHARVHPKFLHSNATSHKWAFGAIAELLDNAVDEIENGATFVKVDRIYNKKDNSPALLFQDDGGGMNPESIRKCMSLGYSSKTSNTTIGQYGNGFKTSTMRLGADVIVFSRASRSGRATQSIGLLSYTFLRRTGHDDVVVPMIDFDISDHWAEPIIYSSHNDWSANLKTILDWSPFSSKDDLMLQFEDIGSHGTKIIIYNLWLNDEGIYELNFDEDDEDIRLRDEANRGSLLKPTKQVIELQSHISYRIRYSLRAYASILYLRKFMKFKILLRGKAVEQFDIAADLKHPETIFYRPQLAGATKEVSVSTILGFNKEAPSIAVSGFNVYHKNRLIRPFWKVTADGSSKGNGVVGVLEANFIEPAHDKQDFERSSLFLKLEMRLKQMIFDYWKGHCHLIGYQPQRSRLHNVESKSAVSSRSEVAGMQKPMQTGKSMHEQPLVVDLSNESFEEERSMEPPSKVASIDQLCEENIQLFMRCEEYGQKENELKRTIEELEKELAETRMKCTKLSLHLETQRKQKLVEQQMDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U178</accession>
    <name>A0A068U178_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00039586001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U178"/>
    <dbReference type="STRING" id="49390.A0A068U178"/>
    <dbReference type="Gramene" id="CDP02246">
        <property type="protein sequence ID" value="CDP02246"/>
        <property type="gene ID" value="GSCOC_T00039586001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U178"/>
    <dbReference type="OMA" id="FMIKGVE"/>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U178"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP02246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="97" mass="11066" checksum="706B7B3A465767E5" modified="2014-10-01" version="1">MQPFRKGREYQVQRRLLPQPSLHRFVDLSQAINMVNYYASSSEPAHVHGKTVYIQYSNRHEIVNNKSPGDVPGNDLLVFMIKGVEAGDVSIDFIHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2B7</accession>
    <name>A0A068U2B7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RIK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Rough sheath 2-interacting KH domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00039671001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2B7"/>
    <dbReference type="FunCoup" id="A0A068U2B7">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2B7"/>
    <dbReference type="Gramene" id="CDP02314">
        <property type="protein sequence ID" value="CDP02314"/>
        <property type="gene ID" value="GSCOC_T00039671001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2B7"/>
    <dbReference type="OMA" id="ATPKPFW"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2B7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22471">
        <property type="entry name" value="KH-I_RIK_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22472">
        <property type="entry name" value="KH-I_RIK_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="5">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="4">
        <location>
            <begin position="219"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00070402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00081001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="593" mass="62588" checksum="E3F6B67F703C7377" modified="2014-10-01" version="1">MTEDNFPRVSSSESTDSSSTKQRKKRKWDQPAESLCSSGVAAPGLLPLPNLGSLPGVALPGVATIPSASFSNSLTASVATILPVIQLPLQQHATAIAQKINQPKIQDELIAREIVINDADSTVRYKLTKRQTQEEIQKCTGAIVITRGKYRPPNAPADGEKPLYLHISAAAHLETTAERIKAVDHAAAMVEEMLKHGSFSNTMNVNPSLSACVFLGFEADPSLNIAARIRGPNDQYVNHIMNETGATVLLRGRGSGYCDSVQDDEGQQPLHLLLSSSNAKSLERAKLLAENLLDTISAEFGASRVSSSKVYGAVPPPPQLLAGVQSSLDESNPSVPRSASLTASAARSIPSTVSSISIPGASSIASQGPVPHAGCSNPASGLSHAITGGYSQSSLTGGTSYNGYDGIYPQATPLQQVALALRQSTSPVTTLVAPAVTTASTASYTSTCSSSEKDKRSSQKRKFQELPAVVKSLANTNQGSELAEPCEQTSDIHGKDIKRLVQTSANGIIPTSPRTMPPPTMLPPPPKFTTSRPGIYGGNSIKNGLKSESVPDTLIKLMEYGDEDEDDDLGEPNEDSIKRCSSTLVAPKPFWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2V4</accession>
    <name>A0A068U2V4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00039891001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2V4"/>
    <dbReference type="FunCoup" id="A0A068U2V4">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2V4"/>
    <dbReference type="Gramene" id="CDP02494">
        <property type="protein sequence ID" value="CDP02494"/>
        <property type="gene ID" value="GSCOC_T00039891001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2V4"/>
    <dbReference type="OMA" id="YSECAPV"/>
    <dbReference type="OrthoDB" id="10070965at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2V4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP02494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="567" mass="65690" checksum="0E6B3983165C38FE" modified="2014-10-01" version="1">MWHEARRSEKKVHDMMDAARKRAQRRAVYLAKRRGDPQQSIQAVGSRCRIYRDDALYHATQDQQGLIPWNGKQDILIDRFDGRALLDFIRDSSSRHIRVPEKSEEEEELEEFVNFERYRDLIKHRRRGFADDEALQHVDQEIEAKINPFGSDRSHPPQPVANKGSYSQVGFSYDGDGKEETHDSDGEEEDEDEDDEDDDEFNSDDSNDVGMESIAKEFGVKRYGWLVYMDKKAKEEERRQKEVIKGDPAIRKLSRKERRKASQMEREREREASRITGTRVLHRDPYRESRRSPTYEAYSRSRRSRSRSRSYSPSHSRRNARGMHSDDVHRSKDRAPKIEYITEFGGSDGNEPKFEGYSPPPSPPTQADALNRPSSGRILEALHVDPASGVSLDKEKNAKLLKPPASTSSALAKLSKATSSGSLTKQQVEKKETPQERLKRIMSKQLNKQIKKDTAVEMAKKREQERQRLEKLAETSRVSRYRHRSRSRSYSRSPSRRYRRSRSRSRGGDSQQRRSRSRSRSLSGSSSSSPHSHSRSRSQSRSYSSSRSHSRSISRSGSPRARRRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3N0</accession>
    <name>A0A068U3N0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00039491001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3N0"/>
    <dbReference type="FunCoup" id="A0A068U3N0">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3N0"/>
    <dbReference type="Gramene" id="CDP02178">
        <property type="protein sequence ID" value="CDP02178"/>
        <property type="gene ID" value="GSCOC_T00039491001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3N0"/>
    <dbReference type="OMA" id="IIQQNIC"/>
    <dbReference type="OrthoDB" id="598358at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3N0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000609">
        <property type="entry name" value="Inactive LRR receptor-like serine/threonine-protein kinase BIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000428">
        <property type="entry name" value="Inactive LRR receptor-like serine/threonine-protein kinase BIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000415">
        <property type="entry name" value="Inactive LRR receptor-like serine/threonine-protein kinase BIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF86">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657312" description="Protein kinase domain-containing protein" evidence="13">
        <location>
            <begin position="30"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="304"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP02178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="602" mass="65972" checksum="FB43DB27F020520D" modified="2014-10-01" version="1">MAESSPKLISLILLIYLVTISNLGKFVIAEDDVKCLRGVKSSLRDPDGRFSLWNFSNSSVGFICDFVGVSCWNPNENRLIGLLLRDMNLSGGVPDALQYCHSLQTLDLSGNDLSGPIPPQICDWLPYLVTVDLSGNALTGTIPEDLVKCSYLNSLVLDDNKLSGNIPYQFSTLGRLKKFSVANNGLSGRVPSFAGVELNFDGNSGLCGGPLRKCGGLSKKNLAIIIAAGVFGAAASMLLGFGAWWWYFTKSGPRRRKGGYGIGRDDSDSWAERLRAHKLTQVMLFQKPLVKVKLADLFVATNNFSAENVIYSTRTGTTYKAVLRDGSALAIKRLSTCKMGEKQFRMEMNRLGQLRHPNLVPLLGFCVVEEEKLLVYKHLSNGTLYSLLSGNATILDWPTRFRIGLGAARGIAWLHHGCHPPIMHQNISSNVILLDEDFDARIMDFGLARLMTSSDSNESSFVNGDLGEFGYVAPEYSSTLVASLKGDAYSFGVVLMELATGQKPLEVGCAEEGFKGNLVDWVNQLSSSGRIKDAIDGALCGKGHDEEIVQFLRIACNCVVSRPKDRCSMYQVYESLKSMAEKQGFSEQYDEFPLLFGKNDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3W6</accession>
    <name>A0A068U3W6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00041497001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="5"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3W6"/>
    <dbReference type="FunCoup" id="A0A068U3W6">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3W6"/>
    <dbReference type="Gramene" id="CDP03027">
        <property type="protein sequence ID" value="CDP03027"/>
        <property type="gene ID" value="GSCOC_T00041497001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3W6"/>
    <dbReference type="OMA" id="HPLNARA"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3W6"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22582">
        <property type="entry name" value="BRcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000018">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000230">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="128"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003976"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP03027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="338" mass="38220" checksum="0CA4564F75D9B1D0" modified="2014-10-01" version="1">MGTKAPEVVILTEDLKNGYDDDDDADVSVLYAKPFSRKEGVNPENPISVESYSDDRDLQLAIMASLQPQSKISSSDYFIYDLDDDDEVQLIASFSTTPRKKLFTGESSNSKATANNDHDNVDSGDVDVTFMCDICVDEKPKAALFCIKGCTHSYCSECMAKYVASKLQDNITSIYCPVPGCNGRLEPEYCRSILPVQVFDRWGDALCEALLLASEKFYCPYKDCSSLLVDDRGGSDEAITHSECPECRRLFCAKCRVPWHSEISCDEFQMLNKDEREREDILLMNLARSKKWKRCPECKIFVERISGCLFMKCRCKYTFCYNCGAQMGTNHYCANCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U427</accession>
    <name>A0A068U427_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">xyloglucan:xyloglucosyl transferase</fullName>
            <ecNumber evidence="1">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00041832001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>breaks a beta-(1-&gt;4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan.</text>
            <dbReference type="EC" id="2.4.1.207"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="1"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U427"/>
    <dbReference type="FunCoup" id="A0A068U427">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U427"/>
    <dbReference type="Gramene" id="CDP03295">
        <property type="protein sequence ID" value="CDP03295"/>
        <property type="gene ID" value="GSCOC_T00041832001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U427"/>
    <dbReference type="OMA" id="PTHIARM"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U427"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF93">
        <property type="entry name" value="ALDEHYDE OXIDASE GLOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654523" description="xyloglucan:xyloglucosyl transferase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="601"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="897" mass="100146" checksum="60266CFBE48D85A6" modified="2014-10-01" version="1">MAVLLKAFLVLPLVFLGAFAGTPINQVQKHGFSLGIRNPFGSIQFGFGGQDGGNFDGFQQPPGGTQQPSGKKPEFLTNFRGRWEIHSENAGVSAMQFQLLPNNKAVWFDTTNLGPSGLQFDPPYCHPNFNNASLIDCYAHAVEYDTETGSVRPLKFSFDPWCSSGGLAANGEVISTGGAIEALRAVRTYTSCDNCEFQENQVALAENRWYSGQQTLEDGSFLLVGGRDVFSYEIVPQNQLQFEPRLFQLPFLRETRDEKENNLYPFVYLLPDGNVYVFANSKSIILNPYTGETIRQLPELAGGSRNYPVSGMSVLLPLQLSADGSHNVDVEVMVCGGNAPDAFKYSENPPRKFLPALNDCNRLSLTQENADWDKEIMPSRRTMGDALLLPTGDVLMLNGAKAGTSAWESADDANFTPVLYRPTAAKGKRFKTLKPTHIARMYHSTSALLIDGKILVAGSNPHQFYTFNVKYPTELRVEKFTPPYLAPELDKHRPVIVEDASDKELKYGQQFVVNINLDDQVDASDIKVTMYPPPFTTHGFSQSQRLLVLGLTQVTNQQITAVAPPSGKIAPPGYYMLFVVHRGVPSRGMWVHIISIKERIDHWSSFINMACFRVLCVALFLSAFAFHSSAVNGSIIKSMYISWGAQHTAIQGDDLALLCFCFPGTGAQSKKTFLFGSIEMLIKFVPGNSAGTVTAYYLSSTGDKHDEIDFEFLGNSSGQPYTLHTNVYIQGVGNREQQFYPWFDPSADYHNYTIHWNKNAIVWYVDGIPLRVFRNYESKGIPYPSQQGMRVYTSLWNADEWATRGGLVKTDWNSAPFIARIRNFRPRACFWNGPVSISQCALPSPANWWNTPAFNQLSAAKMGQMNWVRNNYMIYDYCKDTKRFNGVMPAECSLPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5R9</accession>
    <name>A0A068U5R9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00016323001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068U5R9">
        <property type="interactions" value="2438"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5R9"/>
    <dbReference type="Gramene" id="CDP03831">
        <property type="protein sequence ID" value="CDP03831"/>
        <property type="gene ID" value="GSCOC_T00016323001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5R9"/>
    <dbReference type="OMA" id="KMRHNWL"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5R9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000580">
        <property type="entry name" value="Protein peg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="270"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="776"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1437" mass="158095" checksum="58797F1ADD89F097" modified="2014-10-01" version="1">MEEALELARAKDTKERMAAVERLHQLLEASRKSLSSSEVTSLVDTCLDLLKDNNFRVSQGALQALASAAVLSGEHLKLHFNALVPAAVERLGDAKQPVRDAARRLLLTLMEVSSPTIIVERAGSYAWTHKSWRVREEFARTVTSAIGLFASTELPLQRAILPPILHMLNDPNPAVREAAILCIEEMYNQIGPQFRDELQRQNLPATMVKDINARLERIEPKARSADGLVSNYAASEIKSANLSTKKSSPKAKSSTREVSLFGGDGDVTEKPVEPIKVYSEKELVREFEKIASTLIPDKDWSIRIAAMQRVEGLVIGGATDYPCFRVLLKQLVGPLSTQLSDRRSSIVKQACHLLSFLSKELLGDFDACAEMFIPMLFKLVVITVLVIAESADNCIKTMLRNCKVSRSLLRIADSAKNDRSAVLRARCCEYALLILEYWADAPEIQRSAEVYEELIKCCVADAMSEVRSTARTCFRMFAKTWPERSRRLFMSFDPAIQRIINDEDGGIHRRHASPSVRERSLHMSFTSHTSASNLPGYGTSAIVAMDRSTSLSSGTSISSALFLSQSKSSSKSTERSLESVLNASKEKVTAIESMLRGLNLSEKSRSSSLDLGVDPPSSRDPPFPLAVPASNSLANALAVDTTSGMSKSNSHNGGLVMSDIISQIQASRDSGRLSYRGGAGSESLSAISSYSAKKVEKLHETGLLEENFDFREARRTMNSHVERHYADTPYRDGNLRESHNSYVPNFQKPLLRKNAAGRMSAGRRRSFDDSQLSLGDMSNFVEGPTSLHDALSEGLSSSSDWSARVAAFNYLRSLLQQGPRGIQEIVQSFEKVMKLFFQHLDDPHHKVAQAALSTLADLIPACRKPFESYVERILPHVFSRLIDPKELVRQPCSSTLETVGKTYGIDSLLPALLRSLDEQRSPKAKLAVIEFAIGSFNKHASNTEGSGNSGILKLWLAKLTPLVHDKNTKLKEAAITCIISVYTHFDSVAVLNFILSLSVEEQNSLRRALKQYTPRIEVDLMNFLQNKKRSKCLYDPSDVIGTSSEEGYVGASKKNPLLGRYSSGSIDSDGGRKWSSAKELAHITGSVSQASDEIQGYLYNGLETGSNNDVMASNSKDVKYIANATSESIGSWTSRDQIGGVDSTANVEATSTPRADLNGLIGSNHQRVNVALAADIETSLQVVHDSPRVAALKPNSALETGPSIPQILHLICNGNDGSPTKNKRDALQQLVEVSVVNDESIWSKYFNQILTVVLEVLDDSDSSIRELALSLVVEMLKNQKHAMEDSIEIVIEKLLHVTKDIVPKVSNEAEHCLTIVLSQYDPFRCLSVIVPLLVTEDEKTLVTCINCLTKLVGRLSQEDLMRQLSSFLPALFDAFGNQSADVRKTVVFCLVDIYIMLGKAFLPHLEGLNSTQLRLVTIYANRISQARTGAPIDAGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U648</accession>
    <name>A0A068U648_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00016505001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U648"/>
    <dbReference type="FunCoup" id="A0A068U648">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U648"/>
    <dbReference type="Gramene" id="CDP03986">
        <property type="protein sequence ID" value="CDP03986"/>
        <property type="gene ID" value="GSCOC_T00016505001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U648"/>
    <dbReference type="OMA" id="QNGDIPY"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U648"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005158260" description="AB hydrolase-1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="149"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP03986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="403" mass="44865" checksum="7BA1C0C8BC7D4B91" modified="2014-10-01" version="1">MALQLCSSSSSLLSLCSLQLLRLSPIASPSDQFLKPTIMPQGILKKKKQKHSLLFCRSSNDESNEDYYLDAPVSVGDGFSFSGGKYSDEPSPADEWFEQGKIVKAHPVGGTGDKAKDPIFGLAMGGGSQTSSDLFRWFCVDSGSADNHPIVLIHGFPSQAYSYRKVLPILSKKYHAIAFDWLGFGFSDKPQPRYGFDYTLDEYTTSLESIIDETTKGKATLVVQGYFSPVVVKYASSRQEKITDLILLNPPLTAKHANLPSTLSIFSNFLLGEIFSQDPLRASDKALTSCGPYVIKEDVAMVYRRPYLTSGSAGFALNAISRAMKKELKPYIEEMRRILMDENWQVNTTIIWGERDRWLSYNGVEEFCIESKHRLIRLPMAGHHVQEDSGEEVAQLIAQVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6P8</accession>
    <name>A0A068U6P8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00041817001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6P8"/>
    <dbReference type="FunCoup" id="A0A068U6P8">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U6P8"/>
    <dbReference type="Gramene" id="CDP03283">
        <property type="protein sequence ID" value="CDP03283"/>
        <property type="gene ID" value="GSCOC_T00041817001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6P8"/>
    <dbReference type="OMA" id="FTHNMLD"/>
    <dbReference type="OrthoDB" id="2021019at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6P8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000373">
        <property type="term" value="P:Group II intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.60:FF:000002">
        <property type="entry name" value="CRS2-associated factor 1, chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="entry name" value="YhbY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044599">
        <property type="entry name" value="CAF1P_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46247">
        <property type="entry name" value="CRS2-ASSOCIATED FACTOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46247:SF1">
        <property type="entry name" value="CRS2-ASSOCIATED FACTOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="YhbY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CRM" evidence="9">
        <location>
            <begin position="259"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="CRM" evidence="9">
        <location>
            <begin position="377"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP03283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="776" mass="86792" checksum="D070978D5DCBD77A" modified="2014-10-01" version="1">MALRPVIQFPVFVPPPPSPPNHRPAFEVRFSRWNNANAQKFIRRERTQKEIEDQIRSQRRFDSAFNIAHNYNPAPPTPTFKSTGTPSSPSHPSIPGKKSKYSKNPQKPRLPFDHPAFKPVLKHKKIPVKRINPSRTTDESTKAEEQENFAPNVKIDEKGLSYEFPEAPFLYQYSYTETPKVKPVGIREPLVAPFEPGTMGRPWTGRKPLPPSKKKLPEFDSFQLPPPHKKGVKPVQAPGPFLPGTGPMYVKSREQILGEPLTKEEIKALVESCKKWKRQLNMGRDGFTHNMLDNIHAHWKRRRVCKIKCKGVCTVDMENVRQQLEEKTGGQVIYSRGGVIYLFRGRNYNYKTRPRFPLMLWKPVTPVYPRLVKRAPEGLTLEEATEMRKKGRNLVPICKLAKNGVYCDLVKNVREAFEACELVRINCEGVNGSDYRKIGAKLKDLVPCVLISFENEHILMWRGQDWKSSLPELRSDAEGMTETESDATTFVGTILEGEAESLTASASSVSNTTKMNTTIKDLNTSSGSWNFEEVESDGSSEYGEEVVGDLTALATSACETYESESPPDVQCAVGSDVLVDFDRSEEEWDGSNSYHNAMLTVSSGPETRLGSTFSNDNHSEPPFTAPFTSSKLEGVSEDRKGISELSSATTPSAEEVLLLLRQAVESGLAVMLEDSSLDADIVYERAVALAKSAPPGPVFSHRRKQLVVPECDKPQSDDLEVKEALKVPEKEVTLSSKRGSGKKTSKGRSMKDIREDYLNVNQPGSLRVDELAKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7T3</accession>
    <name>A0A068U7T3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00017717001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="14"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7T3"/>
    <dbReference type="STRING" id="49390.A0A068U7T3"/>
    <dbReference type="Gramene" id="CDP04357">
        <property type="protein sequence ID" value="CDP04357"/>
        <property type="gene ID" value="GSCOC_T00017717001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7T3"/>
    <dbReference type="OMA" id="REDYVWS"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7T3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000023">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000109">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000134">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF198">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104018" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="79"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="416"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="466"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP04357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="579" mass="64292" checksum="8F4E2CD39E5F3754" modified="2014-10-01" version="1">MAVKSALVFSILLLLFVSVLTTSFASETVEKGKGSEVEEDEDLSFLEEDDAASSSHHDPYAQYHNYENYDDLEDNDSGAAEDGGYEAYTPPAVDEADVVVLKESNFSDFIAKNKYVMVEFYAPWCGHCQALAPEYAAAATELKQEEEKVVLAKVDATEESDLGQKYDIQGFPTVYFFVDGIHTPYPGQRTKEAIVTWVKKKIGPGLNNITTVEEAEQILATESKLVLGFLDAFVGAASEELAAASKLEEDVNFYQTTSSDVAKLFQIDPQVKRPALVIIKKEDEKINHFSGQFTKSAISEFVYKNKLPLVTNFTRDSAPLIFENPIKNQLLLFATANDSEKFLPTFQEAAKAFKGKLLCVYVEMDNEDVGKPVSDYFGVQGDAPRVLAYTGNEDARKFLLEGDLTLSNIKLFGEKFLEDDLKPFYKSDPVPEKNDGDVKIVVGKNFDEIVLDESKDVLLEIYAPWCGHCQTLEPIYNKLGKHLRGIDSLVIAKMDGTTNEHHRAKADGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHATNPFKLQKPALSTQPKGSDATTSDDGSSKDLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8E8</accession>
    <name>A0A068U8E8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00019544001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8E8"/>
    <dbReference type="Gramene" id="CDP04815">
        <property type="protein sequence ID" value="CDP04815"/>
        <property type="gene ID" value="GSCOC_T00019544001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8E8"/>
    <dbReference type="OMA" id="LVMVHAN"/>
    <dbReference type="OrthoDB" id="1657902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="110" mass="12667" checksum="8C85BE5D6DFC2ACD" modified="2014-10-01" version="1">MGGKLSILENRTYYSIELRMWVQPARPDKFEKIIRVKPGGTIRAKAKQEGLLYFDKVLVMVHANGVGTGNCIFPLHLMASAKIICDRNQHGRVVIRRKRAFNFCRLKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8I5</accession>
    <name>A0A068U8I5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00017919001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8I5"/>
    <dbReference type="FunCoup" id="A0A068U8I5">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8I5"/>
    <dbReference type="Gramene" id="CDP04504">
        <property type="protein sequence ID" value="CDP04504"/>
        <property type="gene ID" value="GSCOC_T00017919001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8I5"/>
    <dbReference type="OMA" id="YHSDQHQ"/>
    <dbReference type="OrthoDB" id="593669at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8I5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat I (LRI)" evidence="3">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="251"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="470"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LxCxE motif" evidence="3">
        <location>
            <begin position="179"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="544" mass="60566" checksum="766E9903A3CACEF4" modified="2014-10-01" version="1">MQASQASQTSEAIHMLYHQPFQQIESYNLSPFQVLNSNVCADNSSQGAQVSFQACNEQFATLESLPMTDYVNSDSPSTVSISSNRSPFSPQCSQSYMSDVHHSSDNTYGSPLSGSSGVDDSNELRNVLRELEIKLMEESEIDDSSSCSVNNVVGQPVFSTRGNRVVQMAHTMDLKQLLLACAEAVSNAEISTAQGLMNELEQRVSISGDPIQRLSAYMMEGLRARLLSSGSIIYKKLKCKEPTGPELMSYMHFLYQICPYFKFAYMSANVVIGEAMEHENRIHVIDFCLAQGSQWVSFIQALAHRPGGPPYIRVTGVDDSQSVHARGGGLDVVGQRLANVAASCGVPFEFHGAAISGCEVELENLKVRHGEALAVNFPYMLHHMPDESVNTMNHRDRLLRLIKSLSPKVVTLVEQESNTNTAPFYPRFCETLEYYTAMFESIDATRPRNDKQRISAEEHCIARDIVNIVACEGADRVERHELFGKWRLRLTMAGFVPCPLSFSVGNAIRDMLKEYSPNYRLVDRDGALYLGWKNRALATCSAWR</sequence>
</entry>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
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                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">cv. DH200-94</strain>
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    </dbReference>
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        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="271" mass="30441" checksum="0699D48ED5AB150D" modified="2014-10-01" version="1">MVGFGLLTVGLIDIAGHATLTKEQHWLLSVFLGIVMCKIVHDLTGVVSSVFFSGYAKLDKQGKLEWNNRGFSTFHAIVVAAASLHLLIASDLFDAASQDELIVNRKSPLSDTILGISIGYFLSDLAMIIYHFPVLGGMEYVLHHGLSVFSIIQSLLSGQGQIYILMVLFTEITTPFVNLRWYLDTAGQKNSKLYVCNGLALFLGWLVARILLFMYFFVHLFSHFDQVKEVYTLGFYSLLTVPPVLAMMNAFWFLKIARGLIKTLTRARYRK</sequence>
</entry>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Alberti A."/>
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                <person name="Aury J.M."/>
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                <person name="De Bellis F."/>
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                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
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            <strain evidence="2">cv. DH200-94</strain>
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            <dbReference type="EMBL" id="CDP04822.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7016" checksum="F27F5D758F1B3425" modified="2014-10-01" version="1">MEVGKDNTFFLRTCSLGRQSSATVTDTVKSFFEPREQTSTSSDSNAFACLPAKYVGLGMVEEEI</sequence>
</entry>
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    <accession>A0A068UCN6</accession>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
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                <person name="Daddiego L."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCN6"/>
    <dbReference type="STRING" id="49390.A0A068UCN6"/>
    <dbReference type="Gramene" id="CDP06037">
        <property type="protein sequence ID" value="CDP06037"/>
        <property type="gene ID" value="GSCOC_T00021387001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCN6"/>
    <dbReference type="OMA" id="HEECRIK"/>
    <dbReference type="OrthoDB" id="1938112at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCN6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF60">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="192" mass="22194" checksum="293F1BDB0F94F127" modified="2014-10-01" version="1">MICMISCDLSSTMQIIMAVMGVALVRPYGCCIDLKHSLQYDISLSHSFPCCLTLLEAWHILMNNLRLKIAHRDIMATNVLLEKDLNAKISDFGLAKLMKSYDLYYKLFQQRLMAHEYAMKGYLTDKADVYRFGVVAQEIFIGKRTQTLDWFRYSMWQRDVLQERGNLLELVDPSLGSSYNTDEALRMLNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEY3</accession>
    <name>A0A068UEY3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024155001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEY3"/>
    <dbReference type="FunCoup" id="A0A068UEY3">
        <property type="interactions" value="1258"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEY3"/>
    <dbReference type="Gramene" id="CDP07056">
        <property type="protein sequence ID" value="CDP07056"/>
        <property type="gene ID" value="GSCOC_T00024155001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEY3"/>
    <dbReference type="OMA" id="PPFMAFA"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010483">
        <property type="term" value="P:pollen tube reception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP07056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="574" mass="64224" checksum="BCAECE9898D1100A" modified="2014-10-01" version="1">MAVPAALQWMNGERGVLVLYIARILYAAPISLLAESIALGILSLFALSLEISADHDHDHDPFSRFFKTRPGVSSGILLGAVTLPGLMLSRLIQMLRGLSLNEVGVAELENLQLQYWATFASCFSVLVCFHVILQRQDNGVPSVDSCSNWNKRFSLSCIALCAGICCIAFSAKYQFGWQMVFMLLWVVFHGLVASKLIQRILRTFPACVSIGEALLVTSGLVIYFGDMLQNTVAKIFGYWTSLGYLPVQYVVKRSEISTIIQGMTVGLLLFPLFLKLIFQISGHFKFVDSSRERANHEMKKSFIFYASLAFLLIVVIPLWMQFVHDFHMHPLFWVLDFVFSEPLKTLSLCTYWIALIYASVTRFYDISKNSKTERILLRKYYHLMAVVIFVPALILQPEFLDLAFGAALAVFLILEIIRVWRIWPLGQLVHQFMNAFTDHRDSEILVISHFSLLLGCALPIWLSSGFNDRPLAPFAGILSLGIGDTMASMVGHKYGVLRWSKTGKKTIEGTAAGITSVLVACSVLLPLLATTGYIFSQHWFSLLVAVTTSGLLEAYTAQLDNAFIPLVFYSLLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGK5</accession>
    <name>A0A068UGK5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-phi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00024568001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGK5"/>
    <dbReference type="STRING" id="49390.A0A068UGK5"/>
    <dbReference type="Gramene" id="CDP07334">
        <property type="protein sequence ID" value="CDP07334"/>
        <property type="gene ID" value="GSCOC_T00024568001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGK5"/>
    <dbReference type="OMA" id="QGEKWMD"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGK5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009407">
        <property type="term" value="P:toxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03187">
        <property type="entry name" value="GST_C_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034347">
        <property type="entry name" value="GST_Phi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF96">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="100"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP07334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="25501" checksum="D2D55D75B1521F5A" modified="2014-10-01" version="1">MAGATPMAATTPVKVYGPPLSTAVSRVLACLLEKDAPFQLIPVNMAKGEHKSPDYLKIQPFGQVPAFQDQSINLFESRAICRYVCDQYASQGYRGLYGTNPLVKASIDQWIEAEGQSFSPPSSLLVFQLVFAPRMKIKQDENVINQNVEKLSKVLDVYEKRLGESRFLAGDEFTLADLSHLPNAQYLVNGTDKGELFNARKNVARWWDEISTRDSWKKVVEMQNSPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGQ4</accession>
    <name>A0A068UGQ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00025057001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGQ4"/>
    <dbReference type="FunCoup" id="A0A068UGQ4">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGQ4"/>
    <dbReference type="Gramene" id="CDP07710">
        <property type="protein sequence ID" value="CDP07710"/>
        <property type="gene ID" value="GSCOC_T00025057001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGQ4"/>
    <dbReference type="OMA" id="NMSYHDR"/>
    <dbReference type="OrthoDB" id="2016498at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGQ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF66">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP07710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="537" mass="60859" checksum="0223999215145630" modified="2014-10-01" version="1">MAVSKSNKKKLSYISVPSQIISSMSSTSLESLLLSPKKKALSSPFSVLRIRLLWRNPRFWLFLILVFGVFGMLKVYFNVDPLIPFGRNPCAISQDKLMVLNGGNDDNGDEKSEFWKQPDGLGYRPCLQFSNDYKRASVDIVKDRTKYLMVVVAGGMNQQRNQIVDAVVIARILGAALVVPILQVNVIWGDESEFADIFDLEHFKKVLENDVRIVSSLPSTHVMTRPLEDKMTHLHATPEFIRSRYSRRIRREGVLLLRSLDSRLSKDLPSDLQKLRCKVAFHALRFAPPILELGNKLTERMRSKGPYVALHLRMEKDVWVRTGCLPGLSHEYDEMINNERKRRPELLTSRSNMTYHERKLAGLCPLNALEVARLLKALGAPKTARIFWAGGNPLGGKEALDPLIREFPHFYNKEDLALPGELEPFQKKASLMAAIDYIVSENSDVFMPSHGGNMGHAIQGHRAYAGHKKTITPNKRQMFSHFMNSSLPGAEFKKIIVGLHRDSLGQPELRSSKTRRDVTKYPVPECMCNKMQPHSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHA3</accession>
    <name>A0A068UHA3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00024881001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHA3"/>
    <dbReference type="FunCoup" id="A0A068UHA3">
        <property type="interactions" value="3235"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHA3"/>
    <dbReference type="Gramene" id="CDP07584">
        <property type="protein sequence ID" value="CDP07584"/>
        <property type="gene ID" value="GSCOC_T00024881001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHA3"/>
    <dbReference type="OMA" id="NQHVMSA"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHA3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP07584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="888" mass="100313" checksum="BAFCEB0BB1B32326" modified="2014-10-01" version="1">MAKSSADDEELRRACEAAIEGTKQKVVMSIRVAKSRGIWGKSAKLGRGQMAKPRVLAISTKAKGQRTKAFLRVLKYSTGGVLEPAKLYKLKHLSKVEVVTNDPSGCTFMLGFDNLRSQSVSPPQWTLRNVDDRNRLLMCILNICKDVLGRFPKVVGIDVVEMALWAKENTPTIPKQLGNQQDGPVEVAVAEGDMKVTVEKELVSQAEEEDMEALLGTYVMGIGEAEAFSERLKRELQALEAANVHAILENVPLMDEVLQGLESATNCVEDMDEWLGIFNVKLRHMREDIESIETRNNKLEMHSVNNKSLVEELDKLLERLRIPSEYAACLTGGSFDEARMLQNIEACEWLTNALRSLEVPSLDPCYADMHAVREKRAELDKLKSTFVRRASEFLRNYFASLVDFMISDKSYFSQRGQLKRPDHADLRYKCRTYARLLQHLKSLDKNCLGPLRKAYCSSLNLLLRREAREFANELRASTKASRNPTVWLEGSTGSSQNVNNADTSTVSEAYAKMLTIFIPLLVDESSFFAHFMCFEVPALVPPGGLANGKGGPNDNDDGNDDDLGILDIDDNDSKSGKSTAELEALNESLRDLLDGIQEDFYAVVDWAYKIDPLRCISMHGITERYISGQKADAAGFVRLLLDDLESRISMQFGRFVEEACHQIERNERNVRQVGVLSYIPRFATLATRMEQYIQGQSRDLVDQAYTKFVTIMFVTLDKIGQADPKYADILLLENYAAFQNSLYDLANVVPTLAKFYHQASEAYEQACTRFISTIIYYQFERLFQFARRIEDLMYTITPEEIPFQLGLSKMDLRKVVKSSLSGVDKAIATMYKKLQKNLTSEELLPSLWDKCKKEFLDKYDSFAQLVAKIYPSENIPSVKEMSELLASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHR7</accession>
    <name>A0A068UHR7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025220001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHR7"/>
    <dbReference type="STRING" id="49390.A0A068UHR7"/>
    <dbReference type="Gramene" id="CDP07822">
        <property type="protein sequence ID" value="CDP07822"/>
        <property type="gene ID" value="GSCOC_T00025220001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHR7"/>
    <dbReference type="PhylomeDB" id="A0A068UHR7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF79">
        <property type="entry name" value="PROTEIN STRICTOSIDINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="93"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP07822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="425" mass="47049" checksum="BEA3BC663D73D064" modified="2014-10-01" version="1">MQLDPRVWYLIDTERRWSNFAITTPNRNGCEGPQDHIPTESRCGQPLGLSFNRKSGKLYIADAYKGLLVVGPNGGLATPLANEAEGVPFKFTNDVVVDQNSGILYFTDSSTIYPRRDFDLVISTRDKSGRLLKFEPKTNQVAVLLKNLTFPNGVALSKNGGFLLVAETTNCRILKYSLEPSKAGTVGRFTKLPGRPDNIKRNQEGEFWVAVNSPDNKINPFGLIVKLSQNGDVLKILEAGKGEAWRYSSDVNEVNENLWIGSVTEPYVAKLEFYSYARSEQFQIVNATGPESAVFDINGGGPYTGLSDGRIMKWLENDRRWTNFAITTPNSLVRNKDRQEVLVFVWSTRSCFHGVNKLCYNGKSGELYIADAYMGFLVVGPDGGLAAPLAKEAGGVPFKFTNDVVVDQNSGIVYFTDSSAIYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHS5</accession>
    <name>A0A068UHS5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K+ potassium transporter integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00024319001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739109">
        <property type="protein sequence ID" value="CDP07168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHS5"/>
    <dbReference type="STRING" id="49390.A0A068UHS5"/>
    <dbReference type="Gramene" id="CDP07168">
        <property type="protein sequence ID" value="CDP07168"/>
        <property type="gene ID" value="GSCOC_T00024319001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHS5"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF109">
        <property type="entry name" value="POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="3">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="209" mass="23315" checksum="5E910D2B6C28A650" modified="2014-10-01" version="1">MGLINRPTFVIAILASIIPSQAMTSGIFFIIQQSLLLGCFPRVKTVHTSTMYGGQVYIPEINFLLMISCVVVTGAFRTIAETGNAYVQLEPTVVHVYGRGISGLCYDLKIVRYFCDLMRAGHWFGGGSLPKLHLLQVRSRKLLAISFCNGPNVNNAHLEQCVQKGHLRVKAQGFSAEAQLDNKRGIEVVHFWTRIIKRINTLIIIIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHT1</accession>
    <name>A0A068UHT1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026715001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHT1"/>
    <dbReference type="STRING" id="49390.A0A068UHT1"/>
    <dbReference type="Gramene" id="CDP08036">
        <property type="protein sequence ID" value="CDP08036"/>
        <property type="gene ID" value="GSCOC_T00026715001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHT1"/>
    <dbReference type="OMA" id="RHVFTHE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHT1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF59">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12489" checksum="CC3B339397604E05" modified="2014-10-01" version="1">MAEMLTGKQPIQSQGQDDMVDLPRWVQSVVREEWTAEVFDVELMRFQNIEEEMVQMLQIAMACVAKVPDMRPNMDEVVRMIEEVRQSDSENRPSSEENKSKDSTVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI45</accession>
    <name>A0A068UI45_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polygalacturonase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00026879001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI45"/>
    <dbReference type="Gramene" id="CDP08141">
        <property type="protein sequence ID" value="CDP08141"/>
        <property type="gene ID" value="GSCOC_T00026879001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI45"/>
    <dbReference type="OMA" id="RSEEWIM"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI45"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654940" description="Polygalacturonase-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27535" checksum="EE8DF1187AD72277" modified="2014-10-01" version="1">MNSKMRFLAIPFLFFSFLLSSAKSVTYNVQSYGAKSDGRSDSTNSFLSAWAAACASVAPATIYVPPGRFLVGGASFWGQNCKNNAITIRIDGTLVAPSDYNVLGHTGNWLKFERVNGLSIYGGTLDGQGTGLWACKNSGKHCPQGATSLGFYNSNKVLVSGLSSLNSQFFHINLDGCQNTRLEGVKISAPENSPNTDGIHVQSSSGVTITNSHIGTGDDCISLGPGSSNMWIENINCGPGHGISIGSLGSNLQEPGVKNVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ62</accession>
    <name>A0A068UJ62_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026994001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ62"/>
    <dbReference type="Gramene" id="CDP08229">
        <property type="protein sequence ID" value="CDP08229"/>
        <property type="gene ID" value="GSCOC_T00026994001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="84" mass="9550" checksum="A13D139B37844A77" modified="2014-10-01" version="1">MEKLTELSYLLRSNFGLLILGMGALKGDIWWLGLIAAVIQGYIDKLKLCFRQVPRIYRAGVALRKNIDSIQLINFPIPSFLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKF6</accession>
    <name>A0A068UKF6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00028109001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKF6"/>
    <dbReference type="FunCoup" id="A0A068UKF6">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKF6"/>
    <dbReference type="Gramene" id="CDP08961">
        <property type="protein sequence ID" value="CDP08961"/>
        <property type="gene ID" value="GSCOC_T00028109001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKF6"/>
    <dbReference type="OMA" id="LKLIGMQ"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKF6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009882">
        <property type="term" value="F:blue light photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009902">
        <property type="term" value="P:chloroplast relocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009638">
        <property type="term" value="P:phototropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000133">
        <property type="entry name" value="LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000002">
        <property type="entry name" value="LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000265">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000036">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="22">
        <location>
            <begin position="224"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="23">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="22">
        <location>
            <begin position="521"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="23">
        <location>
            <begin position="591"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="718"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="387"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP08961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117250" checksum="D32596B62579591C" modified="2014-10-01" version="1">MEPASHAQQHKQQSSAPVIPPLPRDSRGSLEVFNPSTYRQASSPVFKQSPSSWQSNWAESPRNNNSDNTNIIRPPEPSEETNLPSSKSGRANAEEITTWMALKDPSSTSTLSSQQQQQSSSSSSSPFAQKTISSIITDSEGLKSPAKSPAAGEVGAAAQRAAEWGLVLQTDRETGKPQGVKVRTSGEEQNSKTGSTRRDSGNSFRSSGDLSDDGTGKDRGFPRVSEDLKDALSTFQQTFVVSDATKPDYPILYASAGFFKMTGYTSKEVIGRNCRFLQGSDTDPEDVAKIREALQAGNGYCGRLLNYKKDGTPFWNLLTIAPIKDESGKVLKFIGMQVEVSKHTEGTKEKMFRPNGLPESLIRYDARQKEQASSNVTELVDAVKKPLRPRALSESNNRPFVRKSSEGGVGQPPHRTDADVNLNLENKAPPRRHSHAGTRTTSSSMERISELPETKPKKSRRLSLMGIMKKGRRSSTADEEFEAKVTMDDNEVDDDSDAEDGRPQSLDDKVRKKEMRKGIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEYSREEILGRNCRFLQGPETDPTTVRKIRHAIDTQSEVTVQLINYTKTGKKFWNLFHLQPMRDQKGEVQYFIGVQLDGSEHVEPLRNCIPESRAGEGAKLVKETAENVDEAVRELPDANMKPEDLWANHSKVVRPKPHRRDNSSWKAIQQILDSGEQIGLKHFRPVKPLGSGDTGSVHLVELHGTEEYFAMKAMDKGMMLNRNKVHRACAEREILDMLDHPFLPALYASFQTKTHICLITDYCPGGELFMLLDRQPMKVLRENAVRFYAAEVVVALEYLHCQGIIYRDLKPENVLLQSNGHVSLTDFDLSCLTSCKPQLLVPEIDEKKRHQKGQQAPIFMAEPMRASNSFVGTEEYIAPEIITGAGHTSAVDWWALGILLYEMLYGYTPFRGKTRQKTFANILHKDLKFPASIPASLQAKQLMYRLLHRDPKSRLGSQEGANEIKKHPFFRGINWALVRCMKPPELDAPLFGTTEAEQGFKVDAGLEDLQTNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL84</accession>
    <name>A0A068UL84_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein FATTY ACID EXPORT 2, chloroplastic-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028174001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL84"/>
    <dbReference type="STRING" id="49390.A0A068UL84"/>
    <dbReference type="Gramene" id="CDP09009">
        <property type="protein sequence ID" value="CDP09009"/>
        <property type="gene ID" value="GSCOC_T00028174001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL84"/>
    <dbReference type="OMA" id="HFRVQAW"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL84"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015245">
        <property type="term" value="F:fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF37">
        <property type="entry name" value="PROTEIN FATTY ACID EXPORT 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="25897" checksum="7E4286CD90514FAC" modified="2014-10-01" version="1">MGELLTFSQSSLLLLPKCQLQHSLRAWNPAAQNLASTLAVSSGHFLATKLVLSPIKCVPKKHVFGGIRATVISDSKMPTTFTVDSAGEGVDVLPDTGGGGNDFGNASGKGGGGGGGNNGGDSNDSNESEGDSGESKDENLGSSKKTALSMSQKLTLVYAFLVGAGGLMGYLKSGSQKSLISGGLAASLLYYVYTALPTKPVFASSLGFGLSAALLGVMGSRFKRSGKIFPAGIVSLVSLIMTGGYLHGIMRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULR4</accession>
    <name>A0A068ULR4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00028386001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULR4"/>
    <dbReference type="FunCoup" id="A0A068ULR4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09169">
        <property type="protein sequence ID" value="CDP09169"/>
        <property type="gene ID" value="GSCOC_T00028386001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULR4"/>
    <dbReference type="OMA" id="ICSQQFC"/>
    <dbReference type="OrthoDB" id="9514740at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681:SF4">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655022" description="C2H2-type domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="384" mass="42193" checksum="BE44E8E77F02B43F" modified="2014-10-01" version="1">MASLRPLLSNLLYLLLLLLLHLGCFIFNTSSSSSHRQSKKRKLSDTPVTPSPPASRLKFTPSKALSSSWSFLKRAFCSKPATPTSSPAAIPILSPSSSTRSLTQPATAIHLGSSDTLLSDHQTSIRPVSESDISSDQPFFPLRNNIYPCPICGEIFQNPSLLEQHQSVKHAVSELVDGDTGKNIVNIIFRTGWPGMAKSPAVHRILKIHCGPKILMRFEEYRECVMSAAAGNGGVRRRDERCIADGNELLRFHCTTFLCELGQNGNSSLCNHQYCSVCGIIASGFSPKMDGISTLSTSWRAHASIPEDMEEEFKYLRVKRAMLVCRVIAGRIGCDPEDADKLDPGFDSLVGRENGVPARLDEEDELLVFNPRAVLPCFVIVYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM54</accession>
    <name>A0A068UM54_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Holliday junction resolvase MOC1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00029989001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM54"/>
    <dbReference type="FunCoup" id="A0A068UM54">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UM54"/>
    <dbReference type="Gramene" id="CDP09615">
        <property type="protein sequence ID" value="CDP09615"/>
        <property type="gene ID" value="GSCOC_T00029989001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM54"/>
    <dbReference type="OMA" id="QLLPWTH"/>
    <dbReference type="OrthoDB" id="1910737at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UM54"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22992">
        <property type="entry name" value="MOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045290">
        <property type="entry name" value="MOC1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36015">
        <property type="entry name" value="HOLLIDAY JUNCTION RESOLVASE MOC1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36015:SF6">
        <property type="entry name" value="HOLLIDAY JUNCTION RESOLVASE MOC1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31049" checksum="6DCDDC49970FEBA4" modified="2014-10-01" version="1">MTPFSTKLAQPFLLRFSSTVATTFKLFSTATTLTPSVDHAVVITPDQLIPPARRKSSRGKKGNKLITEAQLRQNWLDSLSCPFPEKIDDNSSSNSNCSSDLLNFHGNGSPNLGSEWVIGVDPDASGALALLKPGHSAQVFDSPHLKVPIGRRLRKRLDTKSIVQLLNSFNAPMGTTAYIEQSIPYPKDGKQGWWSGGFGYGLWIGILVASGFSVIPVPSAVWKNGFRLSGSSSTKDDSREAASMMFPSLSSQLKRKKDHGRAEALLIAAYGKSLKMSLYDSCLVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMA0</accession>
    <name>A0A068UMA0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00027770001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMA0"/>
    <dbReference type="STRING" id="49390.A0A068UMA0"/>
    <dbReference type="Gramene" id="CDP08708">
        <property type="protein sequence ID" value="CDP08708"/>
        <property type="gene ID" value="GSCOC_T00027770001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMA0"/>
    <dbReference type="PhylomeDB" id="A0A068UMA0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9276" checksum="E1EB715700384547" modified="2014-10-01" version="1">MQVRLCRTKNTGEIFALKKLRKLDMLRQGQVEHVRFERNLLVEVDKRIFFLKMLPDSTLLKVFLFLCIIHVRDLIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMC8</accession>
    <name>A0A068UMC8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00029981001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMC8"/>
    <dbReference type="Gramene" id="CDP09611">
        <property type="protein sequence ID" value="CDP09611"/>
        <property type="gene ID" value="GSCOC_T00029981001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMC8"/>
    <dbReference type="PhylomeDB" id="A0A068UMC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP09611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="7907" checksum="3F09C74C5DA249E9" modified="2014-10-01" version="1">MLSLGSFKNGAILLARLFVYDIFWVFFTQVMISVVKSFDAPIKVSVSYCVLYIFNRNSCTWILSIIVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN09</accession>
    <name>A0A068UN09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Argonaute 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00030079001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN09"/>
    <dbReference type="FunCoup" id="A0A068UN09">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN09"/>
    <dbReference type="Gramene" id="CDP09667">
        <property type="protein sequence ID" value="CDP09667"/>
        <property type="gene ID" value="GSCOC_T00030079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN09"/>
    <dbReference type="OMA" id="PTNQEYK"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000091">
        <property type="entry name" value="Protein argonaute 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000008">
        <property type="entry name" value="Protein argonaute 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="8">
        <location>
            <begin position="236"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="9">
        <location>
            <begin position="521"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP09667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="98018" checksum="C5B8442470281E61" modified="2014-10-01" version="1">MARRGLGTKGQKIQLLTNHFKVAVKNVDGQFFHYSVALFYEDGRPVDGKGIGRRVLDRVQETYDTELAGREFAYDGEKSLFTVGPLPRNKLQFTVVLEDVTSNRNTGNSSPGGHESPNDGDRKRLRRPYQSKTFKVEISFAAKIPMQAIGNALRGQETENSQEALRVLDIILRQHAAKQGCLLVRQSYFHNEPRNFADVGGGVLGCRGFHSSFRTTQGGLSLNIDVSTTMIIQPGPVVDFLIANQNVRDPYSIDWVKAKRVLKNLRVKTSPTNQEYKITGLSEKPCKDQMFSLKQRSRDDDGEVQTVEVSVYDYFVNYRHIELRYSGDLPCINVGKPKRPTYFPIELCSLVSLQRYTKALSTFQRASLVEKSRQKPQERMSTLTTALKINNYDEEPLLRSCSITISRNFTEVDGRVLPAPRLKVGNGEDFFPRNGRWNFNNKRLLQPAKIEKWAIVNFSARCDIRGLVRDFMKCGEMKGIDVESPFDVFEENQQYRRAPPLVRVEKMFEEIQAKLPGAPKFLLCLLPERKNCDLYAPWKKKNLSEYDIVTQCMAPTRVNDQYLTNLLLKVNAKLGGLNSLLAVEHSPSIPVVSKIPTLILGMDVSHGSPGQSDIPSIAAVVSSRQWPLISKYRASVRTQSPKLEMIDTLYKRVSDTEDDGILREALLDFYVSSGKRKPDQIIIFRDGVSESQFNQVLNIELDQIIEACKFLDENWSPKFVVIVAQKNHHTKFFQPNAPENVPPGTIIDNKVCHPKNYDFYLCAHAGMIGTTRPTHYHVLLDEVGFSPDDLQELVHSLSYVYQRSTTAISVVAPICYAHLAATQLGQWMKFEDTSETSSSHGGVSHAGSVPVPQLPRLKENVCNSMFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNA2</accession>
    <name>A0A068UNA2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030224001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
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        <property type="protein sequence ID" value="CDP09767"/>
        <property type="gene ID" value="GSCOC_T00030224001"/>
    </dbReference>
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    <dbReference type="OMA" id="SCRWENP"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2_NT"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
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        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="904"/>
        </location>
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        <location>
            <begin position="992"/>
            <end position="1023"/>
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            <begin position="1030"/>
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            <begin position="185"/>
            <end position="204"/>
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    <sequence length="1089" mass="124456" checksum="DA21BD2F3FE6FE8D" modified="2014-10-01" version="1">MFKSARWRSDKNKIKAEFKLQFHATQVSQIGGDGLTISVVPADVGKPTVKLEKATFRDGSCFWDTPFIETVKFVREPKTGKIHERIYHFLIGTASLKAGVVGEASLDLSCYALATKISSVSLPLKNSKSAIVLHVSIQRMLDSVDHREIEESENLKQNSQDRSLKAKLSNGDMEGGGIKKHTNDETTLNVKTNHSAELNGNCRASSGSDVTTSSSDSSLGLNTQIQIRPTSDVSEQINEECQKSWEWLGGLVLEESTDDSSGTPREALLREISQEAPDIVVEKLTSELSALARQAKMSELELQTLRKQIVKESRRGQELSRDISKLKEERESFREECEKLKAFQSRLEEAKSRNKMQFEGGDPYAFIEELRQELNYEKDLNNNLRIQLQKTQESNSELILAVRDLDEMLEQKNKETSRLPNKSAALDSAKMLQEATYGREIDDDDDEEQRALEELVKEHTGSREAHMLEQKIVDLQSEIDICRREKEEIEMQMEQLALDYEILKQENHDISYKLEQSQLQEQLKMQYECTSSYASVNELEAQIESLENELNKTSQDFSVALNTISELEGQLKNLEEELEKQAQVYEADMEALTSAKVEQEQRAIRAEESLRKMRWQNASTAERLQEEFRKLSVQMASTFEANENLAAKALTEANELCLQKSHLEEKLHNASEELQLVSHHYEARLHELSNKVISMSNHMEELQSEIQDKSVQLEDQVKSAEEIQLHLMQEIQMLKSEISTLAMENKNLSDQAEERESLRFEIENMRRSSKELELLLLQANNERAELESKVALAKDKEELSLKELHSMRYLKHEKESTTKNLQIEVDNFKLQCEELKQTLSEDALEKEKLKKQVLQLKGDLKRKEDAFNSMEKKIKDSNGRVTASDGTKGTSKNNKFQNASRTPKEVASLKEKVKLLEGQIKLRETALEKSTSSFLEKEKDLQNKIEELEQRLEVLNHNTTSFCQENCYKISEAPKDLTLDSRLAEDVMDATGKQSTDACIPEENSAPSSRKSHDDLTQNDVKSCASDSRVEELLSELTSLKERNSMMEVELKEMQERYSEISLKFAEVEGERQQLVMRVRNLKSAKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNH5</accession>
    <name>A0A068UNH5_COFCA</name>
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        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00030688001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich repeat family protein"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF31">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655067" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="24"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="592"/>
            <end position="863"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP10085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="884" mass="97240" checksum="74856CBA72205E63" modified="2014-10-01" version="1">MAIFSRCFVLLSFSFSFFLLASASSEADILLSFKDSIEDVSNTLSSWSDTTAIHHCNWTGVTCTNTFPQNVYFIDLQSMNLSGEISPSICQLPNLTNLNLADNLFNQAIPLHLSQCASLETLNISNNLIWGTIPEQISQFQFLKVLDFSRNHIEGKIPEGIGLLNNLQVLNLGGNLLTGSVPMVLGNCSELVVLDISQNPFLLSEIPADIGKLNKLEMLLLQSSGFYGQIPNIFEGLKSLSILDLSVNNLTGSLPPIGMSLPNLVSFDVSQNKLFGPFPNGICEAKDLANLGLYSNSFNGSIPNDLIKECSNLERFQVQNNMFTGNFPSWLWSLPKLKLIRAENNRFSGEIPDSISKATQLEQVQIDNNSFVSKVPQGLGLVSSLYRFSASQNKLYGELPPNFCDSPVMSIMNFSHNYLSGGFPEVKKCRKLVSLSLADNNLVGEIPQSLADLPVLTYLDLSHNNLSGPIPEGLQNLKLALFNVSFNRLSGRVPLSLISGLPASFLQGNPDLCGPGLPNTCSGDQSRHRTANLSKLTGALSSIALVFVVAIVAFGVYVLRQSHKQKSQMDAWKSVFFYPMRINEHDLIMAMDGKAARGDGGAFGQVYIVNLPNGESVAVKRLENFRSQSFKALKTEVKTLAKIRHRNIVKILGFCHNDDSLLLIYENISRGSLGDVIRKPDSQLPWTIRLRIAIGVAQGLAYLHQDYLPRLLHRNIKSRNILLDADFEPKLTDFALDRIVGETAYQLSLASGSEKSCYIPPEYGHTKKATEQSDAYSFGVILLELVTGRQAEQPAAMDSLNVVKWVRRKINLKNGAVQVLDPKISQNCQQAMLAVLEIAVQCTSVVPEKRPRMSEVLKALQSINSRNSLASKELSSSGESSVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP15</accession>
    <name>A0A068UP15_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030915001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP15"/>
    <dbReference type="FunCoup" id="A0A068UP15">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UP15"/>
    <dbReference type="Gramene" id="CDP10250">
        <property type="protein sequence ID" value="CDP10250"/>
        <property type="gene ID" value="GSCOC_T00030915001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP15"/>
    <dbReference type="OMA" id="MMNPTHA"/>
    <dbReference type="OrthoDB" id="993453at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UP15"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34807">
        <property type="entry name" value="OS08G0270800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34807:SF3">
        <property type="entry name" value="OS08G0270800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="310" mass="34760" checksum="83B6C55FF3523C01" modified="2014-10-01" version="1">MSKKAKRVAGETSLPPYGGGGVYEDPKTRLKHQALLQDYQDLQKDTDDLRNKFDAAKQRKLRLMAEVRFLRRRHKYLLKMKSSNRLQELPLNIEKQHNLNGKGRISQKRETALFKLPPLPKPKPKGKMHSGKEAAMKNIAPILDLNRRQTLDSGKEANLCSSTPVSQLNLRKRIASGTEAAVPNSEATNNLNKIQKMQVANDITAFASRRQLFDLNQDTSLINGTSLGDKEATLCSRAPTFDLNEISTEEEEPQNNYEPSNGETKVGLMRGGNEEQSNDLKLSVCRNVGEGSSRIGKRKISWQDPVALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPY3</accession>
    <name>A0A068UPY3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00031368001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPY3"/>
    <dbReference type="FunCoup" id="A0A068UPY3">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPY3"/>
    <dbReference type="Gramene" id="CDP10600">
        <property type="protein sequence ID" value="CDP10600"/>
        <property type="gene ID" value="GSCOC_T00031368001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPY3"/>
    <dbReference type="OMA" id="NNGFRCY"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46137">
        <property type="entry name" value="OS05G0310600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46137:SF4">
        <property type="entry name" value="PROTEIN LEAD-SENSITIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="259" mass="27708" checksum="0ECC6062883BCAF5" modified="2014-10-01" version="1">MGLLSNRIDRGSLKPGDHIYSWRTAYIYAHHGIYVGDDKVIHFTRRGQEVGTGTILDFVLVSSGPSRGHVPCTTCTLTEEGHGVVSTCLNCFLAGGVLYRFEYAVNPALFLAKARGGTCTLAVSDPDDIVVHRASYLLNNGFRCYNVFKSNCEDFAIYCKTGLLVLDHSTMGQSGQAVSIIGGPLAAVLSTPLRLVTTNVYGMAATAVGVYCASRYATDIGMRSDVVKMPVEDLTQRLETGLLGVAIPSLPALPPTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPY8</accession>
    <name>A0A068UPY8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00031086001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPY8"/>
    <dbReference type="FunCoup" id="A0A068UPY8">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UPY8"/>
    <dbReference type="Gramene" id="CDP10377">
        <property type="protein sequence ID" value="CDP10377"/>
        <property type="gene ID" value="GSCOC_T00031086001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPY8"/>
    <dbReference type="OMA" id="DLVYWAV"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPY8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000040">
        <property type="entry name" value="Nudix hydrolase 19, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000008">
        <property type="entry name" value="Nudix hydrolase 19, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="208"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP10377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="398" mass="43951" checksum="0726ACDA33746F95" modified="2014-10-01" version="1">MSINLNSHAFAGNPIRLNTPKSSDPFSPTSAFQTLKTLLLSHTHEPSSPDFKVLPFRKGRPLAGSVCDASGSGGKPSWHLGWLSLGECRAFLENSEVNLNEDSLVYLGFTAEDDVVYWAIDVSEATGLVSEFGARQFCFVELRTLMVATDWIDAKAMGELAVAGHARALLEWHTSSRFCGYCGAKTVPMDAGRRKSCSNELCKRRVYPRVDPVVIMLVIDKENDRALLSRQSRFVPRMWSCLAGFIEPGESLEEAVRRETWEEAGIEVGEVVYHSSQPWPVGPSGIPCQLMVGFFAYAKSLEINVDKEELEDAKWHSREDVKKALTFAEYKKAQRTAADRVDQICKGVEKGQNLSADFSVESGELASMFIPGPFAIAHHLISSWANQVVVNGAETHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR36</accession>
    <name>A0A068UR36_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00031862001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR36"/>
    <dbReference type="FunCoup" id="A0A068UR36">
        <property type="interactions" value="2069"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UR36"/>
    <dbReference type="Gramene" id="CDP10906">
        <property type="protein sequence ID" value="CDP10906"/>
        <property type="gene ID" value="GSCOC_T00031862001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR36"/>
    <dbReference type="OMA" id="RWEPVFH"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR36"/>
    <dbReference type="UniPathway" id="UPA00372">
        <property type="reaction ID" value="UER00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009698">
        <property type="term" value="P:phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655003" description="AMP-dependent synthetase/ligase domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="100"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP10906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="697" mass="75942" checksum="EB9B5FACA7C5FE75" modified="2014-10-01" version="1">MSAYIVGVLVPLVVTFLLRSSKSEKKRGVPVDVGGEPGYAIRNSRFPSPVETAWEGITTLAELFEQACKQHFDKRLLGTRKLISREIETSKDGRSFEKLHLGDYEWLTYGQAFEAVCNFASGLAQLGHGKGERVAIFADTRAEWFIALQGCFRRNVTVVTIYASLGEEALCHSLNETEVTTVVCGHKELKKLIDISGQLDTVKRIISMDDELPSNSASVSASVSWTLISFSDLLRLGQGHPVDPELPLAADIAVIMYTSGSTGLPKGVMMTHGNVLATGSAVMTIVPGLGTKDVYMAYLPLAHILELAAENIMAAVGISIGYGSPLTLTDTSNKIKKGTKGDASVLKPTLMACVPAILDRVRDGVRKKVDATGGLAKKLFDLAYARRLSAVNGSWWGAWGLERLLWNFLVFRKIRAILGGRIRFVLSGGAPLSGDTQRFINICLGVPIGQGYGLTETCAGGTFSEEDDTSVGRVGAPLPCSYVKLIDWPEGGYLTSDSPKPRGEIVIGGPNVTVGYFKSEEKTREVYKVDEKGMRWFYTGDIGQFHADGCLEIIDRKKDIVKLQHGEYVSLGKVEAALIISPYVDNIMLHADPFHSYCVALVVASQAAIEEWASKKGIEYTDFSDLCQKEETIKEVHGSLVKAAKAARLEKFEIPAKIKLLSEPWTPESGLVTAALKIKRESIRKAFSEDLAKLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URP2</accession>
    <name>A0A068URP2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ECERIFERUM 26-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033258001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URP2"/>
    <dbReference type="FunCoup" id="A0A068URP2">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URP2"/>
    <dbReference type="Gramene" id="CDP11175">
        <property type="protein sequence ID" value="CDP11175"/>
        <property type="gene ID" value="GSCOC_T00033258001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URP2"/>
    <dbReference type="OMA" id="WVTANNC"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URP2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF115">
        <property type="entry name" value="PROTEIN ECERIFERUM 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48208" checksum="CCF24DBF04320D15" modified="2014-10-01" version="1">MVSSKEGKSGGLIYNMKLSSVGPGRYTGQDIVHEPNDMDLAMKLHYLKGVYYFPSQAFDGLTIRKIKEPLFIWFNHFYITCGRFRRSEESGRPVIKCNDCGARFIEAQCDKTLDEWLEMKKHDPALEKLLVSDKIVGPELGFSPLVFLQYTKFKCGGMAVGLSWTHVLGDAFSAAEFMNVLGRVLAGEEPQRLLNTAQSLNKNQDAGSPKSVMEDPLSVKRVGPVEDKWITVNTCNMGTFSFHVTPTELSDIQSKISGKYGPKIAPFESLCAVIWKCVAKIRHGNEPKVVTICKKDSRNKGDGRLSNSQMISVVKADFAIAKASHEELAAMIKNQAIDERKKIEEAMERDQGLADFEVYGANLTFVNYEDANFHGFEYNGTKQVGVSYWIDGVGDEGAVLVLPGPNDGGFGRIVRVILPENEIVELRREWSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URQ7</accession>
    <name>A0A068URQ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030967001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URQ7"/>
    <dbReference type="FunCoup" id="A0A068URQ7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URQ7"/>
    <dbReference type="Gramene" id="CDP10288">
        <property type="protein sequence ID" value="CDP10288"/>
        <property type="gene ID" value="GSCOC_T00030967001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URQ7"/>
    <dbReference type="OMA" id="ITELQHW"/>
    <dbReference type="OrthoDB" id="2020598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040265">
        <property type="entry name" value="CHUP1/IPGA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
        <property type="entry name" value="PROTEIN CHUP1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342:SF16">
        <property type="entry name" value="TALIN_MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="80095" checksum="0C04D25B753580E1" modified="2014-10-01" version="1">MKQVLRCFCDFLKSLGDSWINNGEWMVKCKYDASIKLNQNDLEDIAQSMLEDMNKLARERMFDMMDEDEQMNGYSPSETAFGKALSESYSDSKNSLSSSPATPTSVLQDMTNMLSKGTKQSYTPPLLLQLRVQAVEKLNPIDIKRLSFHMLPHAAAPDPNYPLQKSKHESVSKAAGTNEVNQDFEMEEDTFDVVMTNSDESAIEAGKTRTTIENLVTGPVPCTPAKGDIDVVPPPTSLPKLRSNVSEKENTPQIPVEYKLPLDKIASQGSAAPPPPPPPPPQMFPKNEVLLARQCQTQLLETICPTPPPPPPIPSPIAEGSIAITPPPPPPPPLPPVTSMSTTFFPPPPPPPPPPSTSNIPGSIAPPPPPPPPSSMPSGNFTFHPPPPPPPMGSGKIAPPPPPPPMGASNGGVPAPPPPMQPGMRGPPPPPPGLGGAKDPRLRKAATKLKRSSQMGNLYRLLKLKVEGGSNLDAKSSRKGKISSTSGGQQGMADALAEMTKRSAYFQQIEEDFKNHEKSIRELKVSINSFQCSDMTELHKFHKHVESILEKLTDETQVLARFEDFPTKKLEALRMAAALYSKLDTIITTLKNWQIESPVGPVIDKIEKYFSKIKQELDALERTKDEESKKFQSHKINFDFGILVRIKELMVDVSSSCMEQALKERRDAKAMENAQKGPKTECPKKRSGKMLWKAFQFAYRVYTFAGGHDDRADQLTRELASEIQTDPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV73</accession>
    <name>A0A068UV73_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00035577001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with CIPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP12172.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="218" mass="24891" checksum="46BB4DE7C2248643" modified="2014-10-01" version="1">MNSMASCFCLKRAGRPTLEEHSILASETSFTVNEVDALYTLYEKLSSSITDDGLLHKEDFQLALLDSSNKHTFFADRLFDLFDLKHNGVIEFGEFVRSLSIFHPRAPEADKIAFSFKLYDLRCTGYIEHDELKEMVLALLRESELTLPDDVVEAIVNKTIMEADLKGDGRIDPEEWKELVARHPSVIKNMTLPHLKEITLAFPSFVMKTRVQDSELFS</sequence>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
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                <person name="Bocs S."/>
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                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
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                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CDP12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Coffea canephora</name>
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
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                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
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            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP12522"/>
        <property type="gene ID" value="GSCOC_T00036131001"/>
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    <dbReference type="OMA" id="HKSVFHA"/>
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    <dbReference type="PhylomeDB" id="A0A068UW42"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.100.10">
        <property type="entry name" value="Orn/Lys/Arg decarboxylase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
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    <dbReference type="InterPro" id="IPR052357">
        <property type="entry name" value="Orn_Lys_Arg_decarboxylase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43277">
        <property type="entry name" value="ARGININE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43277:SF4">
        <property type="entry name" value="ARGININE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="Ornithine decarboxylase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655307" evidence="6">
        <location>
            <begin position="28"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/Lys/Arg decarboxylase C-terminal" evidence="8">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="600" mass="65055" checksum="EE7329586DD18D5B" modified="2014-10-01" version="1">MVSPLLRLTVFLLTELALWQSFSPSFGSVWSSKLNERPKACILQDNSTSVVHVLIAGNFTTSKQLGILYIVKADFQDEYHMALGRKEDMNRQGEMKGSVSMHNTPTNVSEIIQDYRLPPLVGALKASAAENAASFHFPGHNRGQAAPSSFSELIGKQPYLHDLNGVPELDHLFTPEGPILEAQKQAAELFGASETWFLVGGSTCGIHAVIMATCSPGDNVILPRNCHISAISGMILSGVHPKYILPDYDADWDIAGGITPSQATIEELEMKGQRAGAVLIVSPTYHGICSKVAEISKLCHSHGIPLIVDEAHGAHFGFHELLPDSALCQGADLVVQSTHKVLCSLTQSSMLHRSGDLVDRDRICRCLQMLQSSSPSYLLLASLDAARAQVSENKDIIFHNAIELAMEARSRMSKIHNVSVLDIASFPHFPDMDPLRVTIGTKQLGLSGFEADDILSKDFGVVSELVGTRSITLAFNLGTQREHILRFISGLKHLSAISAASNCTKYSENPDHVMPFDGFSMRLSPREAFFAQKTKVGIKDSIGQICGELICPYPPGIPVLIPGEVISEGALAYMLQVRDKGVVINGASDHLLSSLLVCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXD5</accession>
    <name>A0A068UXD5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RPM1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00037679001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXD5"/>
    <dbReference type="Gramene" id="CDP12967">
        <property type="protein sequence ID" value="CDP12967"/>
        <property type="gene ID" value="GSCOC_T00037679001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXD5"/>
    <dbReference type="OMA" id="EGMERWE"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="174"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="440"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="549"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="108599" checksum="F9A71494301170AD" modified="2014-10-01" version="1">MAETVLSFVLRQLSTFLHEEGRLLGGLRQEVQFIMDELGQMRAFLREAEAREEDAQPTLQQWIKQVRDAAYDTEDILDDFVARFARHRATGFYGSVRRIFSSIKNLRARHRVASEIQSIKSRIKSISKAHKRYKSDYGISAQASNSLSAVNNTTWRYSRDDALLVEEAKLVGIDQPKKRLISQLLEEDDYQLKVVSVVGMGGLGKTTLVKKVHEDLEVRRHFPVRAWVTVSQTCDFQDLLKDLIRQLHKEGKKPVPQSIESLNTTELKEFIKDFLQQAGRYAIVFDDVWDVEFWNTIKFALPESSHGNRVMLTTRKADVASAPCTESLGYIHRMEPLPFEDSWTLFCNKIFKGNSCPGHLMDVAKVILDKCEGLPLAILAISGLFALKDVNRTEEWEMVRCSLGSELEGTGKLDRVKKILSLSYSELPWHLKTCLLYTSIYPEDHKIECYRLVNLWIAERFVEGREGMSIEDVVWSYLSELVNRSLIQVTGVFYEGLPDYCRIHDLLREVILLKSREQNMVTVITGQPTISSSNNTQHHQQIPNYCFDHLRSFVTIGCTNPLLSKPLLSEVLGSSKLLKVLDLGDQETQEEIPNEIFKMFHLQHLSLGDTGVGRVPKAIGKLQHLEHLNLGNTRVRELPMEILKLKKLRFLRVFQQVDSSDVDYGYHGFKAPSNMGGLLALEVLDSIDASSGSTIVKEIGKLTQLRELYITKLRREDGKELCSSLANLTNLRELSVTSIGKGDDHEIIDLNHHHHPSLSSSSSSSFLQSLRMLILRGRLERMPKWIVHLHGLVRIDLDWSRLREEENPLESLQHLPNLGEINFCGSYQGEGLCFKAEGFLKLKCLELRRMEGLRWMRVEEGALPRLQKLFLEQLPLLEELPMGIQHLTQLQELSLYEMSCQLSEKLLENQKEKSEDYTRIAHIPEILIGYYTDDGEWRHHSLWAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYE3</accession>
    <name>A0A068UYE3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00038122001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYE3"/>
    <dbReference type="FunCoup" id="A0A068UYE3">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYE3"/>
    <dbReference type="Gramene" id="CDP13244">
        <property type="protein sequence ID" value="CDP13244"/>
        <property type="gene ID" value="GSCOC_T00038122001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYE3"/>
    <dbReference type="OMA" id="KNGFMSV"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYE3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010405">
        <property type="term" value="P:arabinogalactan protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF42">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655343" description="Alpha-galactosidase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="393" mass="44138" checksum="B3E6A0AFBB4623BC" modified="2014-10-01" version="1">MQILALIVVLFAFCDSLQRGMSKRPSLSESEVRAGCPPRGWNSYDSFCWTISEEEFLQNAELVAQRLHSHGYEYVVVDYLWYRRKVKGASVDSLGFDVIDEWGRMIPDPERWPSSKEGKGFTQIANRVHDLGLKVGIHVMRGISTQAFNANTPILDINTGKAYEESGRKWYAKDIGIKALSCQWMRNGFMSVDTKLGAGRAFLRSLYHQYAAWGVDFVKHDCVFGDDLSIDEISFVSKVLSEINRPILYSLSPGTSVTPSMARDVSSLVNMYRITGDDWDTWGDVASHFDVSRDFAAANMIGANGLKGKSWPDLDMLPLGWLTVAGTNDGPHRKCNLNLDEQRTQMTLWSMVKSPLMFGGDMRNLDETTFSLITNPTLMEINSFSSNNMEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ76</accession>
    <name>A0A068UZ76_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RPM1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00037665001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ76"/>
    <dbReference type="STRING" id="49390.A0A068UZ76"/>
    <dbReference type="Gramene" id="CDP12953">
        <property type="protein sequence ID" value="CDP12953"/>
        <property type="gene ID" value="GSCOC_T00037665001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ76"/>
    <dbReference type="OMA" id="CAFPENY"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="171"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="560"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="109820" checksum="389EB7CF3D9ADBBB" modified="2014-10-01" version="1">MAETVVSFVSDHLATLLREEGSLLGGLRQEVQLIKDELGHMKAFLKVAEAKEEDDPRLQEWIKQVREAAYDIEDVLDEFVLRFAGYRHHGFCGSLQRILKAIKSLRARHQVASEIQSIKSRIKNISEGRQRYQVEFGIDDRVTGSSTMNDSWRYSRDDALLVEEAKLVGIDQPKQHLISKLLEGHDHQLKVISVVGMAGLGKTTLVKKVHEDPDVRKNFPVRAWVTVSQTCDFPKLLRDLIRQLYEEGKEPVPQSIESKTTAELKEFVKDFLQQAGRYAIVFDDVWDVEFWNEIKFALPEGNYGNRVMLTTRKADVASASCTESQDYVYKKEPLSIEDSWTLFCNKIFKGNRCPAHLMDVAKAVLDKCDGLPLAIVAIGGLLASKDVSRIDEWEMVRRSLGGELEGTGKLDRVKRILSLSYNDLPSHLKPCLLYLTIYPEDYLIHCSVLVLSWIAERFVEWREGMSIEDVAWGYLSELINRSLIQVTDVFYGGLPEKCQIHDLLREVILIKSREQNMVTVTTGQPMTWPSEKVRRLVLHSSSNRSIIPHHQHRQFYSFEHLRSFITFSSTNPLLSKTFLSEVLRSSKLLKVLDLEDEEIEETPNEIFNLLHLTYLSLYGTKVARVPRAIRKLQHLEYLNLGNTRVRELPVEILKLQRLRDLRVYQQVDPSDEDFGFHGFKGPSKLGGLLALQRLDTIDASSGSVIVKEIGKLTQLRDLYITQLRREDGKELCSSLANLTSLRQLSVDSVGKGDDSEIIDLNHYHHSLSSSSSCSFLRSLRVLIMHGRLETMPAWTTHLQNLVKINLYWSGLRGEKDPLEFLQHLPNLDTINFCGCYQGEGLCFKAGGFQKLRWLSLKGMEGLRWMAVEEGACPHLRTLVLDRLPSLEDLPSGIQHLSHLQELYLNEMSSQLMEKVGNQKEDGEDYRRMAHIPEIVIGFYADDGEWIIRRLWGKKKKTILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ94</accession>
    <name>A0A068UZ94_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pectinesterase</fullName>
            <ecNumber evidence="4 12">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00038982001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 12"/>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ94"/>
    <dbReference type="FunCoup" id="A0A068UZ94">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZ94"/>
    <dbReference type="Gramene" id="CDP13860">
        <property type="protein sequence ID" value="CDP13860"/>
        <property type="gene ID" value="GSCOC_T00038982001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ94"/>
    <dbReference type="OMA" id="NGAGWEQ"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ94"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000008">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF87">
        <property type="entry name" value="PECTINESTERASE 63-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104035" description="Pectinesterase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="72"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="367" mass="39855" checksum="7296BC5117B8D575" modified="2014-10-01" version="1">MGDMALNKAILFSTLLFIPLVLSDNTVPAPADKAQLNSWFEQNVQPLASRKDTLDPALVAAEANPRIIKLKSDGSGEFKTIADAINSIPNDNTNRVIISLGPGNYTEKIKIERNKPFITIIGDPNHMPTLVFGGTAAKYGTVESATLIVESDYFNAANLILANSAPRPNGDVKGAQALAVRIGGDKASFYNCKFLGFQDTLCDDKGKHLFKDCYIEGTVDFIFGNGKSIYLNVELHVIPGDRQAWITAQARHTDAEDTGYSFVHCKVTGTGRTAYLGRTWMPYGKVVFAYTDMSDAVIPAGWSNNFHPETEKTVLFGEFSSTGPGSDTSSSRAAFTKKLTEAEVKPFLTLGFIEASKWLLPPTQVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZE9</accession>
    <name>A0A068UZE9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00038835001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZE9"/>
    <dbReference type="FunCoup" id="A0A068UZE9">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZE9"/>
    <dbReference type="Gramene" id="CDP13781">
        <property type="protein sequence ID" value="CDP13781"/>
        <property type="gene ID" value="GSCOC_T00038835001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZE9"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="3366at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZE9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3120.10:FF:000004">
        <property type="entry name" value="Chloroplast trigger factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000001">
        <property type="entry name" value="Trigger factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1050:FF:000004">
        <property type="entry name" value="Trigger factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="entry name" value="Trigger factor ribosome-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="entry name" value="Trigger factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="TRIGGER FACTOR CHAPERONE AND PEPTIDYL-PROLYL CIS/TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560:SF3">
        <property type="entry name" value="TRIGGER FACTOR-LIKE PROTEIN TIG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="Triger factor/SurA peptide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="Trigger factor ribosome-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger factor ribosome-binding bacterial" evidence="8">
        <location>
            <begin position="87"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger factor C-terminal" evidence="9">
        <location>
            <begin position="369"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="537" mass="60635" checksum="CBCFB7311C68EF21" modified="2014-10-01" version="1">MVLYGTATASTLLEFKASLLSPCPSFGSRPVNPLIQAVKNTIFFPAIKHVSSNSPSQQFKKISNTFVASASTAEVDTLVEKLPADLNVTETEEPNSRVRLSVEVPPVVCEDCYRRVIREFMKKAKVPGFRPGKNVPESILINYIGKQNIQKAIVESILKRTLPHAMSSMTGKALEDSIRIVTKFSEMENTYSSLNSLRYDIIVDVAPEVKWVPEYGYKNLKIVVEIDSEIDAKKASEEELRHRHKSLGSLRIVTDRGVKLGDVAVLDISATTIEADDSDAKSIPSAESRGFQFDTEDGDRILPGFLEAITGIQRGETKTFQYVFPESWAQENLRGIEAKFTVECKELFYRDLPDLDDSIADKLLPGCTTLEEVKKALLEKCLEVEQTAKEQAADNAILDRLCKMVEVDIPRSLFEEQGRELYGAQLLQMQANRQLNDQQLAYLSSAKAVNEFLENNKENINHVIKQNLAVGDIFKRENLQFSTEELVKEVKNSIAEFKRHNQEYDEERVKEQVQEVLEGAEVLEWLRENAEIQYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZL4</accession>
    <name>A0A068UZL4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DEK-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00038763001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZL4"/>
    <dbReference type="FunCoup" id="A0A068UZL4">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZL4"/>
    <dbReference type="Gramene" id="CDP13722">
        <property type="protein sequence ID" value="CDP13722"/>
        <property type="gene ID" value="GSCOC_T00038763001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZL4"/>
    <dbReference type="OMA" id="WHENEDK"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZL4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000220">
        <property type="entry name" value="DEK domain-containing chromatin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF22">
        <property type="entry name" value="DEK DOMAIN-CONTAINING CHROMATIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DEK-C" evidence="8">
        <location>
            <begin position="532"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="616" mass="68683" checksum="939ED82EA83471C0" modified="2014-10-01" version="1">MGEEDAVPEVAEATANGEAAPEEKSGTGAEKVEKEEVTEMEEDKKDDENVEDQKMDVDKEGEETEEKKEEFEGEEKEGKVEEGNEENKGEEVEEDAGTKVNEENEEEKVEAEVDGLKEEKENLEDVKEDRESVKEQKGSKKRSKRKPVSGEKDKSKKKEVEKKKKEEPKTPAAPAIERPVRERKSVERLVAAIDNEGAKEFRIEKGHGTALKDIPNVAYKLARKKSDDTFKLLHTILFGRRGKATQIKSNISRFSGFVWHDNEEKQKIKVKEKLDKCVKEKLLEICDVLDIPVVKTNTRKEDIVVKLIEFLEAPHATSDELLADKELSSKGKKRKRVSKGSGSATGSTPSKSSAKSRKKTDTASEKGEKKDVSESEDESEEVEEEEEEQEEADEEENANGVPEKSDDELSDQAESDKEHESEANSEEEKGKDKHGSKKAPTKEDSAGSSKSKRVSTPKKSSPPSKSTPSKTPPSRSKVTQKTISSPKVSSKKKTMEVDAKERTSTAKKSASKESSGKKVDKGREKPKEEKLKPSDAALRKAICEILKEVDFNTATFTDILKQLAKKFNTDLTPRKSSIKLMIQDELTKLADEADDEEDEGDAEKDERQPSSQDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZV0</accession>
    <name>A0A068UZV0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MO25-like protein At5g47540</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038807001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZV0"/>
    <dbReference type="STRING" id="49390.A0A068UZV0"/>
    <dbReference type="Gramene" id="CDP13759">
        <property type="protein sequence ID" value="CDP13759"/>
        <property type="gene ID" value="GSCOC_T00038807001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZV0"/>
    <dbReference type="OMA" id="DFFCFFR"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZV0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000146">
        <property type="entry name" value="putative MO25-like protein At5g47540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF21">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46135" checksum="647F7800C1C2CD83" modified="2014-10-01" version="1">MPTQVEQGRREMVGVGGLMNHQQKPSDHRKALKRSPTMNLKRLFTKAMRTASLFKSKKSRPKTPIDIVRHATSLLSYLHSASHLSGQKHSDKMSELDVLIREMKLILYGNGESEPVAEACAQLTQQFFKENTLRLLIVCLPKLNLEARKDATQVVANLQRQPVNSRLIASDYLEFNLDLLDLLISGYEDPAMALHYGGMLRECIRHQTVARYVLKSVHVKKFFDYMQLPNFDVAADATATFKELLTRHKSTVAEFLAENYNWFFAEFNSKLLESPNYITRRQAVKLLGDILLDRSNAAVMVRYVSSRDNLRILMNLLRESSKNIPLDAFHVFKLFVANQNKPPDIVNILVANRSKILRFFAGFKIDREDEAFEADKAQVVKEISELEATASIGNSGELRKLKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1C2</accession>
    <name>A0A068V1C2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00040698001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739166">
        <property type="protein sequence ID" value="CDP14357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1C2"/>
    <dbReference type="FunCoup" id="A0A068V1C2">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1C2"/>
    <dbReference type="Gramene" id="CDP14357">
        <property type="protein sequence ID" value="CDP14357"/>
        <property type="gene ID" value="GSCOC_T00040698001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1C2"/>
    <dbReference type="OMA" id="NRWVDSP"/>
    <dbReference type="OrthoDB" id="543442at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1C2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001731">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000051">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase V.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655471" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="294"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP14357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="587" mass="64420" checksum="DF0AF1203F9778AE" modified="2014-10-01" version="1">MLVLIKLILLVISALVGFASSQDLSITYNGFRSANLSLDGIAEVTPNGLLKLTNATNQQQGHAFFPSPVIFKNSAKSPAFSFSTTFIFAIVSECPTLSGHGIAFVVAPTRGLPGDLPSQYLGLFNGTNTGNGTNHVFAVELDTIQSIEFNDIKDSHVGIDINGLNPTQAKPAGYYSNDNGVFQNLNLISGKAMQVWVDYDGTTKHISVTLGPIHASKPSKPLLSLTSDLSSVLHETMYIGFSSSTGSVLTTHYLLGWSFKMNGVAQGLDLSQLPKLPQVGPKKKSKLLTIGLPIFLIASLSIAISGVIYHVRIKKKFAEVLEDWEREYGPHRYKYKDLYIATKGFRDKGLLGIGGYCRRKDELLLVYEYMPNGSLDKFLYEQPEYTLNWSQRFRVIRGVASGLYYLHEGWEQIVIHRDVKASNVLLDSELNGRLGDFGLARLYDHGTDPQTTRFCGRRPIEPHSPTEDDILVDRVFSCWNKGQILEAVDPNMGLDYVKEEVELVMKLGLLCSQSEPTARPSMRQVVLYLDSALALPNLHLLGISATGLSFASQEGFSDFNLSYPSSMGKPFSHASSSAAESLLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1S2</accession>
    <name>A0A068V1S2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042117001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1S2"/>
    <dbReference type="FunCoup" id="A0A068V1S2">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1S2"/>
    <dbReference type="Gramene" id="CDP14700">
        <property type="protein sequence ID" value="CDP14700"/>
        <property type="gene ID" value="GSCOC_T00042117001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1S2"/>
    <dbReference type="OMA" id="LFRHMEL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1S2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF426">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY, DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47407" checksum="4BF624BC9D603ED1" modified="2014-10-01" version="1">MGSYSSNYLRLLSYTKLLASHVNGGRHQKALSLFHHIHASLSFALDPFVFPLALKSCASLHCPDLGTSIHALTYKWSFVSNPFVASALVDMYGKCISISSARRLFDEIPQRNAVVWNAMISLYAHSSDMPAAMDLFEVMDVLPSVSSFNSIIAGFLEMDDGFYKAIGFYRRMLKLGLAPNLITVLALLRACLGVSALNLIKEIHCYAVRNEFEPNMHLRSGLIEAYGRCGCLRNADSVFQQMKERDVVAWSSLISAYALQGEARTALEIFAQMEMVNVKPDGITFLAVLKACSHAGLADEARVYFTRIQNCYGVEANSDHYACLVDVLSRAGRLREAYEVIKGMPVKVTVKAWGALLAASRTYGEVELGEIAGRALLEMEPENPANYVILARIYANAGRPTKAEEIRREMKERGLRATPGSSWTIHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V257</accession>
    <name>A0A068V257_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042105001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V257"/>
    <dbReference type="STRING" id="49390.A0A068V257"/>
    <dbReference type="Gramene" id="CDP14691">
        <property type="protein sequence ID" value="CDP14691"/>
        <property type="gene ID" value="GSCOC_T00042105001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V257"/>
    <dbReference type="OMA" id="MIESHIA"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V257"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF224">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN 1E-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="2">
        <location>
            <begin position="31"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="231" mass="25219" checksum="8F74D78518FFA2D7" modified="2014-10-01" version="1">MESVIGLVNTLQKACTLLGDYGDDGSLPTLWDSLPTIVVLGSQSSGKSSVLESFVGRDFLPRGSGIVTRRPLILQLYKIDPGKEDYAQFLHTGEKKFIDFSIVGKEIQEETDRVTGKAKQISALPINLSIYSPNVVNLTLVDLPGLTKAAVEGQHESIVQEIENMVRSYVEKPNTIILAITPANQDLATSDTIKIAREVDPAGNFCGRVLTNLLRHSLVLTYWLNKCSGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2H2</accession>
    <name>A0A068V2H2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00042532001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2H2"/>
    <dbReference type="STRING" id="49390.A0A068V2H2"/>
    <dbReference type="Gramene" id="CDP15005">
        <property type="protein sequence ID" value="CDP15005"/>
        <property type="gene ID" value="GSCOC_T00042532001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2H2"/>
    <dbReference type="OMA" id="FWGPTFN"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2H2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="108" mass="12349" checksum="EF822124C121ADA6" modified="2014-10-01" version="1">MASFRAFLNSPVGPKTTHFWGPVSNWGFILAGLADTQKPPELISGQMTGVLCVYSALFMRFAWVIRPRNHFLMVTHASNECVQLYQLSRWAKGQWYLQQKEDKPTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V349</accession>
    <name>A0A068V349_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00042441001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739177">
        <property type="protein sequence ID" value="CDP14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V349"/>
    <dbReference type="FunCoup" id="A0A068V349">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V349"/>
    <dbReference type="Gramene" id="CDP14939">
        <property type="protein sequence ID" value="CDP14939"/>
        <property type="gene ID" value="GSCOC_T00042441001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V349"/>
    <dbReference type="OMA" id="STWNHAK"/>
    <dbReference type="OrthoDB" id="761792at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V349"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35110">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35110:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="149" mass="16571" checksum="F89A246ECF77AF69" modified="2014-10-01" version="1">MWLGGGNGAVTTFVRYFSRKRAPNLRKINPKVPQQEAAVIAESLYHIIKQNGPLSVSNTWNHAKEAGINGLNSKTHMKLMLKWMTGRSMLKQTCNHVGSSKKFVLSTLPEESQVNQPKNSVDMVLKSENPNTKGVRQVQSKTKGAKQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3B0</accession>
    <name>A0A068V3B0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00040725001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739166">
        <property type="protein sequence ID" value="CDP14368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3B0"/>
    <dbReference type="FunCoup" id="A0A068V3B0">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3B0"/>
    <dbReference type="Gramene" id="CDP14368">
        <property type="protein sequence ID" value="CDP14368"/>
        <property type="gene ID" value="GSCOC_T00040725001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3B0"/>
    <dbReference type="OMA" id="FTHACGF"/>
    <dbReference type="OrthoDB" id="543442at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3B0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06899">
        <property type="entry name" value="lectin_legume_LecRK_Arcelin_ConA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000108">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase S.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000051">
        <property type="entry name" value="L-type lectin-domain containing receptor kinase V.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000112">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655488" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="24"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="349"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP14368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="674" mass="74199" checksum="993C61E5AAE04E7F" modified="2014-10-01" version="1">MSFTLVTTFLALLVIVHIGADSAAPDDNGFIYEGFQSSNLSLDGIAKITDNGLLRITNITKLQMGHAFYPDPINFKSTPNGSAFSFSTQFVFTIVPQVSGLSGHGMAFVIAPTRGLPVGLPTQFLGLFNDSTNGNASNHVFAVELDTIQTHEFNDINDNHVGIDINSLFSTASQPASYRANNKNSFDNLTLSSAQRMQLWVEYDGESKVINVTLAPIAVAKPNTPLLSLSYDLSPILRETMYVGFSASTGSLAAAHFVLGWSLKMNGVAQALDLSRLPKLPRFGPKKVSQFFTVGLPLICTFLLLVVISGLAYYLGRKWKFAEVLEEWELAYGPHRFKFKDLYIATKGFREKELLGAGGFGRVYKGVLHTNKMEIAVKKVSHQSRQGMREFVAEIVSIGQLRHRNLVPLLGYCRRKGELLLVYEFMSNGSLDRFLYNQPKSTLNWSQRLRVIKGVASGLFYLHEEWEQVVIHRDVKASNVLVDAEFNGRLGDFGLARLYDHGALPQTTHVVGTLGYLAPEHYRTGKATTSTDVYAFGAFLLEVACGRRPIDPQAPGEDEILVDWVFSCWKEGDIVQAIDRKLGSQYVKEEAELVLKLGLLCSHLEPTIRPSMRQVLAYLEGTVPLPELSSIGISAIGLGFTHACGFKCTALSLSSSTDNNFSRSVAKSPLSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3N9</accession>
    <name>A0A068V3N9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00042769001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3N9"/>
    <dbReference type="STRING" id="49390.A0A068V3N9"/>
    <dbReference type="Gramene" id="CDP15167">
        <property type="protein sequence ID" value="CDP15167"/>
        <property type="gene ID" value="GSCOC_T00042769001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3N9"/>
    <dbReference type="OMA" id="HIFITTL"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3N9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF26">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658215" description="Cytochrome P450" evidence="11">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13089" checksum="E519BAECB8580DE6" modified="2014-10-01" version="1">MHSSICYFSLLLLFFFFCLQVLIVAETSTTLRALSWVISLLLNHRHVLQKAQEEIDSSVGKERWVEESDIKNLVYLQAIVKETMRLHPPAPVPMPRQADEDCNVALSWRSSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3T2</accession>
    <name>A0A068V3T2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00042800001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739180">
        <property type="protein sequence ID" value="CDP15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A068V3T2">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3T2"/>
    <dbReference type="Gramene" id="CDP15187">
        <property type="protein sequence ID" value="CDP15187"/>
        <property type="gene ID" value="GSCOC_T00042800001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3T2"/>
    <dbReference type="OMA" id="KIWEVIC"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative receptor-like serine/threonine-protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR052232">
        <property type="entry name" value="RLK_Ser/Thr-Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984">
        <property type="entry name" value="OS01G0323000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47984:SF14">
        <property type="entry name" value="OS01G0323000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="187"/>
            <end position="451"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="509" mass="56899" checksum="407F0032A8C35DDF" modified="2014-10-01" version="1">MASDLNAQLSKSTSIFGLKVWELIGIIVGALIVVILFVLTCYLTSRKKSKRANEQIPFSQIPAVSKEIKEVRVEQVSTNEFTPREGILLTIHDKSSDKESDKVLVHLGTGKTKNADNGSQSGSFHHVERDGCGSQSGEEGSSGTFGAYKNSHPITAPSPLTGLPEFSHLGWGHWFTLRDLELATNRFSKENVLGEGGYGVVYRGKLINGTPVAVKKLLNNLGQAEKEFRVEVEAIGHVRHKNLVRLLGYCIEGIHRMLVYEYVGNGNLEQWLHGAMRHHGYLTWEARMKVLLGTAKALAYLHEAIEPKVVHRDIKSSNILIDDDFNAKVSDFGLAKLLGAGKSHITTRVMGTFGYVAPEYANTGLLNEKSDVYSFGVVLLEAITGRDPVDYGRPPQEVNLVEWLKMMVGSRRSEEVVDPNIESRPSTRALKRSLLTALRCVDPDSDKRPRMSQVVRMLESEEYPIPREDRRHRRTQAGSTEIESQRENYDTDKSDNPEPRSESKRNHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4S3</accession>
    <name>A0A068V4S3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BIRD-IDD transcription factor fourth C2HC zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00015593001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739186">
        <property type="protein sequence ID" value="CDP15651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068V4S3"/>
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        <property type="protein sequence ID" value="CDP15651"/>
        <property type="gene ID" value="GSCOC_T00015593001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4S3"/>
    <dbReference type="OMA" id="MDMFGPQ"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4S3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055185">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593:SF231">
        <property type="entry name" value="PROTEIN INDETERMINATE-DOMAIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22992">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIRD-IDD transcription factor fourth C2HC zinc finger" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="344" mass="36514" checksum="05ACBE0303C3BBB4" modified="2014-10-01" version="1">MFNRKDSFITHRAFCDALAEESARFAPIPSANLNFRNELFNGGLSSLQPAGNPQFSNSIAGLDPATGQLNLNGQKPRLPLWLDNANTQLNNPIGNHPGNSNAFLASSSTSLPELVQMTPTNMLGLSSQNQWFNIGGNASSSGLPRVLKEEEENRGNLSDHISSLYYNNGQNSSQHETAPAHMSATALLQKAAQMGSTRSNSAIFGTGFGLMSSSLSSLSNFNSLNQSRNELQNFGQAENLNGLMTSTSQSTMTTNQGDGLLLGNMSSSNNLVGNLRHPSAPPTIMPGSTDRGGSQSKSSGNEAEGGLTRDFLGVGGNESRPFLQQNELVKFASSMSSAMDFGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V586</accession>
    <name>A0A068V586_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00042598001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V586"/>
    <dbReference type="FunCoup" id="A0A068V586">
        <property type="interactions" value="2997"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V586"/>
    <dbReference type="Gramene" id="CDP15053">
        <property type="protein sequence ID" value="CDP15053"/>
        <property type="gene ID" value="GSCOC_T00042598001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V586"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V586"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP15053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="462" mass="51942" checksum="7C9F3069F1ED92DE" modified="2014-10-01" version="1">MPREIITLQVGQCGNQIGMEFWKQLCLEHGISKDGILEDFATQGGDRKDVFFYQADDQHYIPRALLMDLEPRVINGIQNGEYRNLYNHENVFIADHGGGAGNNWASGYHQGKQYEEDLMDMIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLETLNDRYSKKLVQTYSVFPNQNETSDVVVQPYNSLLTLKRLTLNADCVVVLDNTALNRIAVERLHITTPTFAQTNSLVSTVMSASTTTLRYPGYMNNDLVGLLASLIPTPRCHFLMTGYTPLTVERQANVIRKTTVLDVMRRLLQTKNIMVSSCARTKEASQAKYISILNIIQGEVDPTQVHESLQRIRERKLVALSRKSPYVQTAHRVSGLMLASHTGIRHLFAKCLSQYEKLRKRQAFLDNYRNHPMFADNDLSEFDESRDIIESLVDEYKACESPDYIKWGMEDPDHLLTGDGNATGTVDPKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7T4</accession>
    <name>A0A068V7T4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00019067001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7T4"/>
    <dbReference type="FunCoup" id="A0A068V7T4">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16617">
        <property type="protein sequence ID" value="CDP16617"/>
        <property type="gene ID" value="GSCOC_T00019067001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7T4"/>
    <dbReference type="OMA" id="RWVAHRI"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7T4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF669">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655616" evidence="5">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP16617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="388" mass="42240" checksum="63CFA8F14AAA37C7" modified="2014-10-01" version="1">MEFSGGTVFSVMLLPLYALLIAEGQKMTDSTSSSCDYPAIYNFGDSNSDTGGIAAAFFPMAAPCGETYFHRPAGRASDGRLIIDFIADHLGLPFLSPYLDSVGSNFQHGANFATGGATIRRQNESWFETGVSPFPLDIQVEHYTQFKERSAYFYNQDKVASDKSRLPKPEDFSKALYTFDAGQNDLAAAFRKMSWEELRAALPDIVNQFAKQIRGMYERGARAVWIHNTGPIGCLPASTVKVKNPPPGYLDEHGCIKSQNDAAMEFNTQLKETVVQLRAELSGAAITYVDVYSAKYGLISNAKKHGFEEASKICCGIHGLENDVWCGNKGIVNGSEVYGGSCAEPGGIISWDGVHYTEAANKWIANLVLNGSLSDPPLPIARACHPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V859</accession>
    <name>A0A068V859_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00019185001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V859"/>
    <dbReference type="FunCoup" id="A0A068V859">
        <property type="interactions" value="1650"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V859"/>
    <dbReference type="Gramene" id="CDP16712">
        <property type="protein sequence ID" value="CDP16712"/>
        <property type="gene ID" value="GSCOC_T00019185001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V859"/>
    <dbReference type="OMA" id="ATNMGHM"/>
    <dbReference type="OrthoDB" id="1911901at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V859"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017887">
        <property type="entry name" value="TF_TCP_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005333">
        <property type="entry name" value="Transcription_factor_TCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31072">
        <property type="entry name" value="TRANSCRIPTION FACTOR TCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03634">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51369">
        <property type="entry name" value="TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TCP" evidence="7">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="320" mass="33378" checksum="C16307BFE745A86E" modified="2014-10-01" version="1">MSETNHNNSPTPPPPAEIKDFRICIADKQENTTTSAKKPHQLAPKRSSNKDRHTKVEGRGRRIRMPALCAARIFQLTRELGHKSDGETIQWLLQQAEPSIIAATGTGTIPASALAAAAAGAGGSVSMSAGLHPPKISAELGAHHPPHMDIAGSGQGAGSTGASRTNWPMVGGSLLRAPHMGMPTTTAGIWPPTSASGAVSGFGFQSSSSPAPAATSLGTESSNYLHKLGFPGFDLPAATNNLGPMSFTSILGAATDQQQQLPGLELGLSQDGHVGVLNPQTLSQIYQHMGQARAHQQQQQHQDQQQQQPSPNDNSQGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAQ8</accession>
    <name>A0A068VAQ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00019204001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAQ8"/>
    <dbReference type="Gramene" id="CDP16728">
        <property type="protein sequence ID" value="CDP16728"/>
        <property type="gene ID" value="GSCOC_T00019204001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAQ8"/>
    <dbReference type="OMA" id="DHHYYQD"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043240">
        <property type="entry name" value="CYSTM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47564">
        <property type="entry name" value="CYSTEINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47564:SF1">
        <property type="entry name" value="CYSTEINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP16728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13545" checksum="39AF2A104D74B041" modified="2014-10-01" version="1">MSYQKASPYPPPGTAYAAPPPPGYPSAPPPPSYEGYPPPGPPPPPPPGYPYPPPPRPEGYQQYFNHGYPPPPPPPPPPQPYGVYHSQHHHNDHDDHSGCFSCLRGCLAALCCCCLLEECCLLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBF5</accession>
    <name>A0A068VBF5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00011378001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739226">
        <property type="protein sequence ID" value="CDP17008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBF5"/>
    <dbReference type="STRING" id="49390.A0A068VBF5"/>
    <dbReference type="Gramene" id="CDP17008">
        <property type="protein sequence ID" value="CDP17008"/>
        <property type="gene ID" value="GSCOC_T00011378001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBF5"/>
    <dbReference type="OrthoDB" id="1732566at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBF5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF467">
        <property type="entry name" value="CARBOXYLESTERASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP17008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="107" mass="11777" checksum="9FE8345A52112EAB" modified="2014-10-01" version="1">MSAPSHSSVMFLSSSDKYLFVLPLYSGFQYGSLVKLFLVVQFEVRFGVTKLPLLVYLHGGGFLIKSAFSPTYHAHLNVVVAEAGVVAVSINYRLAPEHPLPLVYEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC54</accession>
    <name>A0A068VC54_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00004341001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739307">
        <property type="protein sequence ID" value="CDP18311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC54"/>
    <dbReference type="STRING" id="49390.A0A068VC54"/>
    <dbReference type="Gramene" id="CDP18311">
        <property type="protein sequence ID" value="CDP18311"/>
        <property type="gene ID" value="GSCOC_T00004341001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC54"/>
    <dbReference type="OMA" id="KNNIGWP"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC54"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF803">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658465" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="14">
        <location>
            <begin position="20"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="15">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP18311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126177" checksum="7C3CD9FF23C09D85" modified="2014-10-01" version="1">MRILLFPWLFLIPLLQILSVRHVVLLASGQCLEDQRSLLRELKNSLTFNSTSSTKLARWNNSKDCCLWDGVGCDSLGHVIRLELDNQTISGLLENSSSLFNLRYLVRLNLAFNNFSSTIPTGLFKLTNLTYLNLSGAGFVGQIPRDLASMSRLVTLDLSTRFPGVQPLEMENPKLQTLVQNLMELQELYLDGVNISAEGGEWGNALSSMLNLREISLSSCHLSGPISSSISELHSLSIINLNTNNLSAAVPDFFANFTNLTSLSLSSCNLLGKFPKKILRLPMLQNIDLSINNFITGTLPRFADSGSLLQTIVISYTNFSGSLPDSIGVLGDLSRIDLSNCNFTGPIPSTMADLTELVYVDLSNNQFNGSIPSFGMSKNLSHLDLSRNDLTGNIPSDHFEGFANLSFINLGYNSFTGKIPPSLFALPSLWKLQLANNNFIGKVEFRNASSPFLDTLDLSGNQLNGSIPMSIFELQMLNVLSLSSNRFNGSLPLQIINRLRNLTTLDLSYNNLSIDASSGNSTLSTFPQLSVLRLASCNLQKFPELRNQSKMIDLDLSNNQIAGEIPRWIWEVGNGSLQHLNLSCNHLVDLPMNATMPNLSVLDLHSNQLQGEFPKPPEAAIYVDYSSNKFSNSIPQDIGNSLNFAVFFSISNNSISGVIPQSLCNASYLQVLDLSNNVLRGSIPDCLFYKMENLEVLQLGRNKLRGIIPDKFPINCVLKSLDLSKNVLEGRVPRSLVNCTSLEVLNIGSNRVEDAFSCVLKNLTSLRVLVLRSNRFYGNLSCSGADDSWQKLQIIDLASNNFSGALSPKCFSNWRGMISRVEYGQSAQDRLHFTVLKLSNIYYQETLTVTFKGLELEFRKILLVFASIDFSNNSFEGSIPETIGELRALYLLNLSHNGLTGTIPKSIGNLTQLESLDLSMNRLSGMIPVEIANLTFLSSLNLSFNQLLGSIPWGRQLQTFTETSYEGNKGLCGPPLNSSCKGNNHAAVPSSVDANSVIETGFDWQFIFTGLGFGVGAAVIVWPLIVCKEGRDWSDKHVERILLLICPRYRFCYTRYDEGKVNAVEKSEDEFLDDTEDSDGDEFEVEHEAFGGKYCVFCSKLDVHKKRAVHNPKCTCHTSPIFFTSPTSSSSLLVLYHQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD41</accession>
    <name>A0A068VD41_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00005111001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739253">
        <property type="protein sequence ID" value="CDP17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD41"/>
    <dbReference type="STRING" id="49390.A0A068VD41"/>
    <dbReference type="Gramene" id="CDP17603">
        <property type="protein sequence ID" value="CDP17603"/>
        <property type="gene ID" value="GSCOC_T00005111001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD41"/>
    <dbReference type="OrthoDB" id="1304856at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VD41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="10190" checksum="EB57400F163DDD0C" modified="2014-10-01" version="1">MDSEFYEGVVDAFDPLSKKHKVLYVDGNEENLNLEKESWFLLGNTSCHQVSCLISYFFFIMLFVVFLLSPPPPPKKNKTKKISLPLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDU4</accession>
    <name>A0A068VDU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_306</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00000814001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739390">
        <property type="protein sequence ID" value="CDP18916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDU4"/>
    <dbReference type="FunCoup" id="A0A068VDU4">
        <property type="interactions" value="2059"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDU4"/>
    <dbReference type="Gramene" id="CDP18916">
        <property type="protein sequence ID" value="CDP18916"/>
        <property type="gene ID" value="GSCOC_T00000814001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDU4"/>
    <dbReference type="OMA" id="YGSSMVQ"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000237">
        <property type="entry name" value="Flowering time control protein FY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000409">
        <property type="entry name" value="Flowering time control protein FY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="709" mass="77726" checksum="8C51D024816C7A4B" modified="2014-10-01" version="1">MMRQPSASSTTLNAPQPHPADYHHPIAQPPPSLHPHPPYDSHGDSFAAKRMRKIGQRRTVDYTSTVVRFMQIRMWQRDSRDRTVLQPTPAAAVDMLPTAAYLDNPSTSFAAKFVHTSLNKNRCSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQAVRSMVWSYNDNWMVTGDDGGAIKYWQNNMNNVKANKSAHKESVRDLSFCRTDLKFCSCSDDTTVKVWDFARCQEEYSLSGHGWDVKSVDWHPTKSLLVSGGKDNLVKLWDAKSGRELCSFHGHKNTVLCVKWNQNGNWVLTSSKDQIIKLYDIRAMKELESFRGHRKDVTALAWHPFNEEYFVSGSFDGSIFHWLVGHETPQVEISNAHDNSVWDLAWHPIGYLLCSGSNDHTTKFWCRNRPGDTAREKFNTGFGEQNSAIGGRMPGNFPGHEAPMTPGPFASGLTRNEGTIPGIGVAMPLSVPSLDSSAQADQKPPTSISTPLGAPPLPPGPHPSLLSSNQQQAYQQNAQLVQQHQQMAQQISLPVPPPNMPQLQPSAHQPLLPHPHLARPPPQLQPLNTPSSMPSSMPGSLPIPGPIGGPMGMQGNMNQMVPPMPQGHFMGMNAMPSGSGLPGNIPPGGIPNGLLNMQGPSNASGSQMFQPGGGFNRPQTGQMQMMPGLNPYQPGNPNPPAMGSLPSNFGLMSGMPPPLPPGPPPHNQTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEG7</accession>
    <name>A0A068VEG7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00001032001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Gly) + glycine + ATP = glycyl-tRNA(Gly) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEG7"/>
    <dbReference type="FunCoup" id="A0A068VEG7">
        <property type="interactions" value="3025"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEG7"/>
    <dbReference type="Gramene" id="CDP18987">
        <property type="protein sequence ID" value="CDP18987"/>
        <property type="gene ID" value="GSCOC_T00001032001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEG7"/>
    <dbReference type="OMA" id="HFVNFQR"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEG7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01200">
        <property type="entry name" value="WHEPGMRS_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="15">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="119"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="735" mass="81967" checksum="3836A85220A3B8A2" modified="2014-10-01" version="1">MHWLPTSSPPSLVRQLVSALISPSSSLLRPLHPPVSLLSRRPLTASTLPMPDGDDSLLRKALADKLATIQAQANAVRQLKASGAPKSDIDAAVQSLNALKLDKASLETQLLQSATNNRDAFRQALVNTLERRLFYMPSFKIYRGVAGLYDYGPPGCAVKSNVLAFWRQHFVLEENMLEVDCPCVTPEIVLKASGHVEKFTDLMVKDEKTGTCYRADHLLKDYCKDKLEKDLTITAEKAAELKHVLALLDDLSAEELGAKIKEYGITAPDTKNHLSDPYPFNLMFQTSIGPSGLTPGYMRPETAQGIFVNFKDLYYYNGNKLPFAAAQIGQAFRNEISPRQGLLRVREFTLAEIEHFVDPQDKSHPKFSEIASLEFLMFPREGQMSGQSAERVQIGEAVAKGIVNNETLGYFIGRVYLFLTRLGIDKERLRFRQHLANEMAHYAADCWDAEIECSYGWIECVGIADRSAYDLCAHSDKSGVALVAQEKYSEPREVEKLVIAPVKKELGLAFKGNQKMVTEALEVMDEKVALQMKADLESKGEVEFYICCLGKNVTVKKSMVSISKEKKKEHQRVFTPSVIEPSFGIGRIIYCLFEHAFYTRPSKAGDEQLNVFRFPPLVAPIKCTVFPLVQNQQYEEVAKFISKSLTAAGISHKIDITGTSIGKRYARTDELGVPFAVTVDSRSSVTIRERDSKDQIRVNMENVAAVVKEVTDGQSTWDDILKAYPLHSSGSVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFC4</accession>
    <name>A0A068VFC4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_385</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00000292001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739469">
        <property type="protein sequence ID" value="CDP19234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFC4"/>
    <dbReference type="STRING" id="49390.A0A068VFC4"/>
    <dbReference type="Gramene" id="CDP19234">
        <property type="protein sequence ID" value="CDP19234"/>
        <property type="gene ID" value="GSCOC_T00000292001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFC4"/>
    <dbReference type="OMA" id="ELIRGHM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP19234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="163" mass="18049" checksum="6B87C61D638853FB" modified="2014-10-01" version="1">MHRLSGRSVSTILRAGGCRRCRNATASISSSNIFHKSAEENDENVRWYSVLTTRQINCGKPIKQLNFGSSHHLLRIRYESTAAASDSSSNPPPEKYEYQAEVSRLMDLIVNSLYSNKEVFLRELIRHALVLFSPFSVSLPAGLVIHGASFSHAAFVVVVGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFD8</accession>
    <name>A0A068VFD8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_485</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00013510001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739569">
        <property type="protein sequence ID" value="CDP19441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFD8"/>
    <dbReference type="Gramene" id="CDP19441">
        <property type="protein sequence ID" value="CDP19441"/>
        <property type="gene ID" value="GSCOC_T00013510001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFD8"/>
    <dbReference type="PhylomeDB" id="A0A068VFD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="181"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="435"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="683"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116252" checksum="270B1EB76EF26841" modified="2014-10-01" version="1">MADAFISSTIQVTLEMALSVASDRIGMLVGFKKDVASMTRSLRLLKGVLADAEAKQNQDGAVQEWLKSLEEVAYEADNVLDKLHYEALRHQVESRNRHKLKVCCFFSFSNINLAFRWRMASKVRDIKDKLKGINQEARDLGLVDRAVVMAALPAALPAGDTGNRQTDSVVAPMVGRADDESKIVKMLLSPSEKVVSVLPIIGMGGLGKTTLAKSIYNKKQIDGQFEKKIWVCVSKKVPVVELFKLILGQLKKDKKDEVGDRQNIVQEIGKELGKLRYLLVLDDVWDDDEALWHDFFTTLKGLNPTNGSWCLVTTRLGPVAHSVSRVLMMENEPYALKGLPDDHCWSIVKEKVVGGEEELKAIKERVIKRCNGLPLAASVIGGLLSLKRKEEWQSILENRLLSLSAGGDHVMQILKFSFDNLPSPYIKKCFAYCSIFPKDSEIERNVLIELWMAEGFLQADINSQMMMEEIGMNYLRILLQSSLFEEIRYDWKTCYMMHDLVHDLVESMSKSTKVINDWDAHVVDNGNHIRYLATDSFGGGEDREKLLESLSTSLHTLFVKRDLSGDMLMKLKNLYVLNLSSATSQELPVSIGKLIHLRYVNLEWYAISILPDSLCKLYNLQTLTLSNSKVEDLPKGMRDLISLRHLHYNTFDEAFQMPLEMGRLTCLQTLEFFNVGREKGRRIGELGSLKNLKGRLIIRNLELVKDKEGAEEAKLSEKANLLRLVLWWASVREGDDYNDGDVLDGLRPHPNLEELLIKNFLGDQFPRWLMDLPTATTLPKLARLNFLGCNRCKELLPLQNFTSLKELEIYECNGLTNLPGDMLRSCTSLQKLTVSWCGNLISFPLDLQQTPSLSELALLGCLKLKTSMTPKGFGFLTSLRKLKIGPFSDDGDDHENSSIYNEFDWSGLISSSSSSSSALRELQLIGLPHMESLPHQIQYLTTLTSLVLNEFGGIKALPDWFGNFAALEELQLFGFKELGHLPSADAMRSLTKLKSLVVWRSTLLKERCTPESSGPDSQWSKVSHIQHLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGD5</accession>
    <name>A0A068VGD5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_669</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00009516001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739753">
        <property type="protein sequence ID" value="CDP19766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGD5"/>
    <dbReference type="STRING" id="49390.A0A068VGD5"/>
    <dbReference type="Gramene" id="CDP19766">
        <property type="protein sequence ID" value="CDP19766"/>
        <property type="gene ID" value="GSCOC_T00009516001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGD5"/>
    <dbReference type="OMA" id="KGKETCI"/>
    <dbReference type="OrthoDB" id="1879545at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGD5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF19">
        <property type="entry name" value="BET V I_MAJOR LATEX PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="3">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP19766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="166" mass="18296" checksum="9EA571BFE73E5265" modified="2014-10-01" version="1">MFGTLSDELEVKAPASEAWKVYGTLLLADVVRQQLPDVLDKIDVLEGDGGPGTKLKLTFPPDNQLMSYSKEQFVVVDDQKMMKVAEVFEGGYLNLGFTLYRVTFQVLPNLNDESSCTTKCILDYELKEDAAENASLINIQPFTAIMKAAANYLETGNATPTTTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGW0</accession>
    <name>A0A068VGW0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00012811001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739769">
        <property type="protein sequence ID" value="CDP19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGW0"/>
    <dbReference type="Gramene" id="CDP19794">
        <property type="protein sequence ID" value="CDP19794"/>
        <property type="gene ID" value="GSCOC_T00012811001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGW0"/>
    <dbReference type="OrthoDB" id="3027644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGW0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="698"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="955"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1049" mass="121532" checksum="C856F623622FC383" modified="2014-10-01" version="1">MESSEKLVKSKNRTSTDFFDSLFVELDGLQDCYRYTDAADEIRITKIEVELLSMFQMVVANWDDADKQHGAGQGLEPLLQDLEAASEKPMSDLRIADSESAVTVAVWPLELNFLRSRPQVEAAYEYVASNYSLKSHDFLSNYHEWNNFLGYLQDIVKKLSHNHPQLSTMYDVLKCLGRYVDKMRGSCPNLHRNLLTHFGGVLVRTAHFSYLCWIHRRDQDKKQGMIIMLSDLLKALMPNTPQFTELCIKLTSSFCSCHSQTPSNDDLVKAYIDFVIPKKVSQLKTFRKRLEDLIFFASSIYVPDRWREDDVKLTLKEIKANISELGSFSYSFHATEETWHADPAFFRLLEKMELLRVEVFLINLLYQRMNLKILDGYVESFQIYQRDASEGESEVHKLTWLYIKTMAKKAVSIYRSVHEKSITEEKFRDELFKVLKKIRLSKIEILMEELLDIQPSLIVHVRAQIENLDQGLRVIRTYLAGPLEENEKLIFTQADSVERDAARFYYPLLENEITEDTVRKFSHLLPELVEKMKFVNAQIKEIYLPYRRSSRSNFPKLEGIRCIDFFLVDLLMQLKTKADSVLSVKHEFHVVHEEIKFLRSFLTEHQDLKSIAVHIIQVTLEAEYLIDLFVVEDCLRWYHQLWLSDLVEDLKLIKLQARETCNNAHGINIHNVPTSSMMVSSPAKIPKIDEVVIDLTDEKKLVIDRLISGSGKLDVVAVVGMAGLGKTTLVRRVYNDPLVTYHFHIQAWCCVSQAYQKRELLLQILSDIVELTDDVLEMSDEELKLKLYRCLRRNRYLIVMDDIWSIEALYDFKRSFPNDDNGSRILITSRHFHVAAEDEVDGTPHSLRRLSDDESRKLLQKKLFDTKECPNELMEVGEQIAASCKGLPLAVIAIAGLLGRTDMILDRWKEVLESICSQTTDDPEMRCMEILDICYRYLPNYLKPCFLYTAVILEDKDIPVKKLAWLWRAEGFLTDTGAESIEDIAEGYLRDLIGRSLVLPSKRRSHGGIKTCRVHDMLRTLCIPESLKKKTFCSSKMGMTNFLILLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHE1</accession>
    <name>A0A068VHE1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00008133001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of a prohibitin multimeric complex in mitochondrial membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739922">
        <property type="protein sequence ID" value="CDP20027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHE1"/>
    <dbReference type="STRING" id="49390.A0A068VHE1"/>
    <dbReference type="Gramene" id="CDP20027">
        <property type="protein sequence ID" value="CDP20027"/>
        <property type="gene ID" value="GSCOC_T00008133001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHE1"/>
    <dbReference type="OMA" id="FICYEIQ"/>
    <dbReference type="OrthoDB" id="1658519at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHE1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="162" mass="18154" checksum="C1BEB0CFDD33B08A" modified="2014-10-01" version="1">MVNLTLQVLSRLEVSRLPNIINTLGLEYDEKVLPSIGNEVLKAVVVQLNADQLLTERPHVSALVRDSLVRRAKDFNIVLDDIAITHLSCGAEFSKALEQKQVAQQKAERSKFVVMKVEQEQRAAIIRAEGESEAAKLISLPAQRFICYEIQTIFGFNSFVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJN4</accession>
    <name>A0A068VJN4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00004424001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741131">
        <property type="protein sequence ID" value="CDP20921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJN4"/>
    <dbReference type="STRING" id="49390.A0A068VJN4"/>
    <dbReference type="Gramene" id="CDP20921">
        <property type="protein sequence ID" value="CDP20921"/>
        <property type="gene ID" value="GSCOC_T00004424001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJN4"/>
    <dbReference type="PhylomeDB" id="A0A068VJN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322:SF1">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="122" mass="14115" checksum="4D2B4AE8CF8C19B3" modified="2014-10-01" version="1" fragment="single">MPKKEQEPRALPPEVQCWCYHSHCECSFASRDALLKHNNSVRGRLKFSCDICDNKFKIFFVCKEPASVFAQHSLKEGLTVFRDPEFSSDMGSSTVKRIADVLKLRIYQFPQLYKVVFVAYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJZ6</accession>
    <name>A0A068VJZ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_2013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00002422001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG741097">
        <property type="protein sequence ID" value="CDP20909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJZ6"/>
    <dbReference type="STRING" id="49390.A0A068VJZ6"/>
    <dbReference type="Gramene" id="CDP20909">
        <property type="protein sequence ID" value="CDP20909"/>
        <property type="gene ID" value="GSCOC_T00002422001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJZ6"/>
    <dbReference type="OMA" id="RINWASK"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000256">
        <property type="entry name" value="oligouridylate-binding protein 1-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000275">
        <property type="entry name" value="oligouridylate-binding protein 1B-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000191">
        <property type="entry name" value="Oligouridylate-binding protein 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF27">
        <property type="entry name" value="OS07G0615400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="136"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="409" mass="44738" checksum="31CDFB80B5599674" modified="2014-10-01" version="1">MQQQRLKQQQQQQQQALMQQSLYHPGLLAHTQIEPILSGNLPPRFDSSTCRSVYVGNIHPQVTEPLLQEVFSSTGPLEGCKLIRKEKSSYGFVDYFDRRSAALAIVTLNGRHLFGQPIKVNWAYASAQREDTSNHFNIFVGDLSPEVTDSTLFACFSVYPSCSDARVMWDQKTGRSRGFGFVSFRSQQEAQSAINDLNGKWLGSRQIRCNWAAKGAANGDDKQSLDAKSVVELTNGTSEDGQEKSGEDAPENNPQYTTVYVGNLAPEVTSVDLHRHFHSLGAGVIEDVRVQRDKGFGFVRFSNHAEAARAIQLGNACILFGKPIKCSWGSKPTPPGTSSTPLPPPAVAHMPGFSATDLAAYERQIALSKMAGAQALMHPQGQRIGAASQAIYDGGYPGIATTQPPIYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKK0</accession>
    <name>A0A068VKK0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_3530</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00004515001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742614">
        <property type="protein sequence ID" value="CDP21350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKK0"/>
    <dbReference type="Gramene" id="CDP21350">
        <property type="protein sequence ID" value="CDP21350"/>
        <property type="gene ID" value="GSCOC_T00004515001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKK0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="34" mass="3845" checksum="28DC219088B9A2C1" modified="2014-10-01" version="1">MGPTEQTFFIASNERTPVQHGCIALWFKLAYSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKK8</accession>
    <name>A0A068VKK8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_2856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00001872001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741940">
        <property type="protein sequence ID" value="CDP21226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKK8"/>
    <dbReference type="Gramene" id="CDP21226">
        <property type="protein sequence ID" value="CDP21226"/>
        <property type="gene ID" value="GSCOC_T00001872001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKK8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8746" checksum="44ED14E9F8D10EB6" modified="2014-10-01" version="1">MNSLGSCIFKSTLPFYTLITLSFFLPFCTRAPLCFFTCTRTLLSSLAHMHFILSFHIPYLAHSRAHFHLHIYCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKM1</accession>
    <name>A0A068VKM1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_3637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00008172001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742721">
        <property type="protein sequence ID" value="CDP21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKM1"/>
    <dbReference type="Gramene" id="CDP21375">
        <property type="protein sequence ID" value="CDP21375"/>
        <property type="gene ID" value="GSCOC_T00008172001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKM1"/>
    <dbReference type="OMA" id="GIECSIM"/>
    <dbReference type="OrthoDB" id="2973320at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKM1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF42">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="519" mass="58565" checksum="36319FFFCA192118" modified="2014-10-01" version="1" fragment="single">MGRLTCLQTLEFFNVGQERGRGIEELGTLKYLKGSLRIRNLGLVKGKDAAKQAKLFEKPDLSYLAFEWESGDRESDNREEDVLEGLQPHPNLQRLQIRYFMGNKFPQWLINLSKLEALWIEDCKRCSELPSLGQLPSLKRLSLTKLDNIRSIGDEFYGITANEEEGRSRGSGSSTRRRKFFPALEILWVIDMGNLVEWKGVDQVRSTTGEAEADVFPMLMDLRISGCPQLTALPCSSDIPMLMDLRISDCPQLTALPCSGKSLHVENCRNLTSIKMGYGAASVEELRIRNCNNLRELPDLDLFGSSLRRLTIKRCPRLISLGVNGQKCPLLRCLEELSIDNCEGLTTISDKMFESCRSLRSLSVWCCPNLVSFSLNLQETPSLEKIFLFKCPKLIPHSLKGFAFATSLRTLTINSPFSSDDSSVDDFDWSGLRSVSTLRELRLQGLSHTESLPHQLQYLTTLTSLSLENFGGIRVLPDWIGNLVSLETLELRDCDKLQSLPPEAAMRRLTKLTGVRVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNA5</accession>
    <name>A0A068VNA5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="8">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00001524001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG751558">
        <property type="protein sequence ID" value="CDP22230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNA5"/>
    <dbReference type="STRING" id="49390.A0A068VNA5"/>
    <dbReference type="Gramene" id="CDP22230">
        <property type="protein sequence ID" value="CDP22230"/>
        <property type="gene ID" value="GSCOC_T00001524001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNA5"/>
    <dbReference type="OMA" id="NIICTAK"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNA5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP22230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7199" checksum="1741035D65A95DE8" modified="2014-10-01" version="1">MSRSLGIPVKLLHEATGHIVTVELKSGELYRGSMVECEDNWNCQLENITFTAKVLSFQCYSALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNB4</accession>
    <name>A0A068VNB4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_10475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012888001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG749559">
        <property type="protein sequence ID" value="CDP22109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNB4"/>
    <dbReference type="STRING" id="49390.A0A068VNB4"/>
    <dbReference type="Gramene" id="CDP22109">
        <property type="protein sequence ID" value="CDP22109"/>
        <property type="gene ID" value="GSCOC_T00012888001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNB4"/>
    <dbReference type="OMA" id="MWYEHAS"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF318">
        <property type="entry name" value="BETA-GLUCOSIDASE 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="154" mass="17412" checksum="6FDCF60899B4D6A9" modified="2014-10-01" version="1" fragment="single">KSTTNPTLSNVFEKVIYSKLKKPNSNHISRDDYLDFVELCFKEFGDRVKHWITMNEPYIFSNGGYDGGTLAPGRCSAWLNNDCPAGNSATEPYIVGHHMLLCHAAAVKLYREKYQASQKGEIGITLVSHWIVPYSSSKLDILATQRALDFMYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQY1</accession>
    <name>A0A068VQY1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">DH200=94 genomic scaffold, scaffold_10737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00013805001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG749821">
        <property type="protein sequence ID" value="CDP22123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQY1"/>
    <dbReference type="FunCoup" id="A0A068VQY1">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP22123">
        <property type="protein sequence ID" value="CDP22123"/>
        <property type="gene ID" value="GSCOC_T00013805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQY1"/>
    <dbReference type="OMA" id="NDTSTRC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000142">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000002">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000003">
        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001019">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase B120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1050">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="18">
        <location>
            <begin position="56"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="18">
        <location>
            <begin position="170"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="376"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP22123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="541" mass="60298" checksum="7886C4786A925FC2" modified="2014-10-01" version="1" fragment="single">CISHFYLNDQAGLNTKIFNCLLLVICLILIKMISRSVLISCFMLICMISFDTRLIYADAWCANSAYNPNSTVGRMYTDNLNFLLSILSSNASLASRNGFYNFTAGHDPSNMVYGLFNCRGDVNPDTCGRCVANARGDILKTCWNRTTAFVWYDECLLRYSNESMFSRADQGIILYAWNTQNATDPDKFNQVLGDMLKEIASQAANDRSGKKFAVKEEDYAPFQRRLYALGQCTPDLSRNDCENCLSNAISQIPTLCNNRQGCRVTFFSCNIRYELYKFYNSTSPPPEPAPNLGPPPSPPSNSTGSEEGGGISTQTIVAIVVPISLAIVLLVVGFCIARRPRKPYFAIMETSGASEISTAESLQYNLSDIQAATNNFAVGNRIGEGGFGPVYKGTLHNGQEIAVKRLSRSSAQGTEEFKNEIALVARLQHRNLVRLLGFCLEGEERILIYEFVTNKSLDYFLFDPEKQPLLDWSRRYKIIGGIARGLLYLHEDSRLRIIHRDLKASNVLLDRNMNPKIADFGMARLFGVDQSEGNTSKIAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VRC8</accession>
    <name>A0A068VRC8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peroxidase</fullName>
            <ecNumber evidence="3">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00011747001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="3"/>
    <dbReference type="EMBL" id="HG752334">
        <property type="protein sequence ID" value="CDP22278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VRC8"/>
    <dbReference type="STRING" id="49390.A0A068VRC8"/>
    <dbReference type="Gramene" id="CDP22278">
        <property type="protein sequence ID" value="CDP22278"/>
        <property type="gene ID" value="GSCOC_T00011747001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VRC8"/>
    <dbReference type="OMA" id="SCERRMA"/>
    <dbReference type="OrthoDB" id="1298004at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VRC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388:SF115">
        <property type="entry name" value="PEROXIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656077" description="peroxidase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP22278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="116" mass="12730" checksum="0027EB5A00F8FC06" modified="2014-10-01" version="1" fragment="single">MAVNKLFGAISALSLLLLLSSFGCKAQLSPTFYDYTCPNALTTIRSTIRSAISCERRMAASLIRLHFHDCFVQNAKTKLGCDGSVLLDETPTIQSEKTSKANNDSARGFNYLTIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKI8</accession>
    <name>A0A068TKI8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00013920001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068TKI8">
        <property type="interactions" value="994"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TKI8"/>
    <dbReference type="Gramene" id="CDO96790">
        <property type="protein sequence ID" value="CDO96790"/>
        <property type="gene ID" value="GSCOC_T00013920001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKI8"/>
    <dbReference type="OMA" id="VESHNMS"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056020">
        <property type="entry name" value="DUF7599"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056062">
        <property type="entry name" value="DUF7645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056063">
        <property type="entry name" value="DUF7646"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056064">
        <property type="entry name" value="DUF7647"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24538">
        <property type="entry name" value="DUF7599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24655">
        <property type="entry name" value="DUF7645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24657">
        <property type="entry name" value="DUF7646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24658">
        <property type="entry name" value="DUF7647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7599" evidence="10">
        <location>
            <begin position="239"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7646" evidence="12">
        <location>
            <begin position="340"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="556"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7647" evidence="13">
        <location>
            <begin position="747"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7645" evidence="11">
        <location>
            <begin position="928"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1455"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1458"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
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            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO96790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1887" mass="213221" checksum="AC3A46A86AE99542" modified="2014-10-01" version="1">MDSVVHSAIEEICSQGGGGLSLLNLWPRLHQSLSAHGLPLCPNVKAALWSNLLNVPGLRFEVEGDVYDCQDALINSLEKCEQMNMKIVASERLRSNFIGITDIEASDSKINEKHRRTLERLAIARTSGVTQSELAKEFGIKGKDIFYILKALECRGLILKQTTVVKTKEACDEGHKKTISNVATNMLHLYRYGKQLGYQQRLEIIKENIPLVDSDVADVTAANSAGFPKGLVKEDVNVKDYLPALKAICDKLEQADGKVLVVSDLKQDLGYRGTSGHRAWRNICPRLKDAGVVEECFTKVKNKEVKCLQLLKKFSPKHFEPKLSRQGYDELDVEQTTKLGKRGQITDQLVELPIDHQIYDMIDAEGSKGLTFTEVCRRLGICNKQYYDRLLDMYPRFGMHLQAESCKRSYVYRFWTSRNFNSEASDIIPCDTAMVMHENTESVPQPVVWETDDSFIPTIQEVDSSTYKDVADDAPVNEPEVCYNSTTNAEDNLMLLTPNNPQSPASEASGRVPDMELGIVNTTASNGTINNISPPVPVPMRRRSYQKYPCLALGAASALREQRILQLLKEEKFLIKAELHRRLEIENLEKEKSSMMDRRTLARSLNKLQEEGQCRCVPIHMPAISNCSASRTIEVVLHPSISNLSDQVLSQIQERHRLFEIQIRRQCYSRMKKGQSTPVLDSVQRIQTSVHSDTQAEQAEARLANGYVLAKMVRTKLLHIFLWNYLRGSHGWNDPLSIEKNGHDMRNPHSTSKMFGLDAAIKAMPLELFLQVVGSTQKFENLIEKCRMGLRLSDLPVEEYRCLMDTQATGRLSRLIDILLRLKLIRLVRAGHSDGEAKVQDITTLVHALELKPYIEEPVSIVASTCGFIFPDLRPHVRHDFVLSTRKVVDEYWNTLEYCYSAADSKAALHAFPGSAVHEIFFPRSWASARVMTVDQRAELLKRVVTDEPHKKLSYGECREIANDLNLTVEQVLRVYQGKRQKRFTSFGGDSYARGNEFDPLRHTSSSSARKRKRSFKGKSPKHAKSETKGGYWSKGRLAQISDTEREDTFITSLGDYGSHLLEERINDQMQAVEQQESNEENEHDQFFIHKYALSKLKTGRQNRFSWTEEADRQLVIEYVRNRALLGAKYHRTDWGSLSNLPAPPETCRRRMAMLNSSPQFRKAVLRLCNMLAERYEKYLEKYQKNSLNLDDGRPLVREAMMVGDCNENLFDCFEHGKELKSHIRWDNFDDCNIKIALDDVLRYKTIAKSNTSKQVDSYEWSHGQDPFNTDKVCQEGQICGGRSTNSAQRSSSYRIVQKYNKLLNEGNTTSRQIYGSVAVSNAAELFKLIFLSTSITPQASILLAETLRRYSQHDLFAAFSYLREKKIMIGGNATSPFALSQHFLHSISLSPFPPNAGKRASKFASWLDRREKDLIEEEIQLPADLQCGDIFHLCGLISLGELSITPCLPEDGIGEAEDSRTSKRKNDTSEYCGDKSKRLKTSMPGEGEIICRREKGFPGIRLSLSRVTVPRMCFLELFEDKDSTGVSLFCDKDQCNSPCPQSGGTSSLSDECTFLNEVKYDLGINCTATAAHKSPWESMTSYADHLVSSFHDGENSPFHTELFRTICSAIQKSGDQGLSMEEIANLLNIAGEKELEIVVDVLEAFGRAFKVSAYDAIHVVDSLYRSKYFLASVAESNQNPQVTPSVDFKGTSHEEHKLINVGSQEDDVGLQDDISTDTDDVHKITILNHPKELTEPLSVIQRSNEVEDHAHSEVISAEVNPRGDTFEVRSCDPFVYPILPWINGDGTINELVYKGLVRRILGIVMQNPGILRDDIIKQMGALNPQSCRKLLEKLIQDKHIIVRRMHQTTCPEPPAILRSLLGSCTKKSKLVYREHLFANPMSTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TMP9</accession>
    <name>A0A068TMP9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="5">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00014446001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="5"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TMP9"/>
    <dbReference type="FunCoup" id="A0A068TMP9">
        <property type="interactions" value="2201"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TMP9"/>
    <dbReference type="Gramene" id="CDO97184">
        <property type="protein sequence ID" value="CDO97184"/>
        <property type="gene ID" value="GSCOC_T00014446001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TMP9"/>
    <dbReference type="OMA" id="GATTHCE"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TMP9"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDO97184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="517" mass="56018" checksum="20AA15B64E6F90F3" modified="2014-10-01" version="1">MEGIISQLHSNIQRVMEGGGAEAVKRNQSRNKLLPRDRIDRLIDPGSSFLEFSQLAGHELYDEPLPSGGIITGIGAVHGKLCLFVANDPTVKGGTYYPITVKKHLRAQEIASQCKLPCIYLVDSGGAFLLKQAEVFPDKENFGRIFYNQALMSAEGIPQIALVLGSCTAGGAYIPAMADESVMVKGNGTIFLAGPPLVKAATGEEVSAEDLGGATVHCKTSGVSDYFAQDELHALAIGRNIVRNLHMAGNHNVSQHRTFDYKEPLYDIKELRSVAPADFKQSLDIRSIIARICDGSEFDEFKKLYGPTLVTGFARIYGQPVGIIGNNGILFNESALKGAHFIELCTQRNIPLVFLQNITGFMVGSKSEANGIAKSGAKMVMAVSCAKVPKITVVVGGSFGAGNYAMCGRAYNPNFMFFWPNARISVMGGAQAAGVLTQIEKANKKKAGVQWTKEEEEKFKADVVEAYEREGSAYYSTARLWDDGIIDPADTRKVVGLCLSASMNRGRENTKYGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNF4</accession>
    <name>A0A068TNF4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021799001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNF4"/>
    <dbReference type="FunCoup" id="A0A068TNF4">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNF4"/>
    <dbReference type="Gramene" id="CDO97865">
        <property type="protein sequence ID" value="CDO97865"/>
        <property type="gene ID" value="GSCOC_T00021799001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNF4"/>
    <dbReference type="OMA" id="TPRFRGG"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNF4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013591">
        <property type="entry name" value="Brevis_radix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044532">
        <property type="entry name" value="BRX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027988">
        <property type="entry name" value="BRX_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058:SF2">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08381">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13713">
        <property type="entry name" value="BRX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51514">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRX" evidence="5">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="BRX" evidence="5">
        <location>
            <begin position="325"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO97865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="42205" checksum="3908B30353CC8562" modified="2014-10-01" version="1">MLTCIACSKQHLNAASLPQPQHDDGDAAAISTPSTRQAIKALTSQIKDIAIKASGAYKNCKPCSGSSNHHNNRGDGCADSEPGSVSGRYQFSYARAAAAAGSSNSTPRRPWGREMESRLKVPSSGETTPASVSGRTESVVFMEEDEPKEWVAQVEPGVLITFVSLPQGGNDLKRIRFSREMFNKWQAQRWWAENYDKVMELYNVQKFNQQAVPLPTPPRSEDEISKMESAEDSPATPPLNKERLPRNFHRALGMGHYSSDSLENHPMHPRTYYESAGLTSTPKLSSVSAARTETSSIDASARSSLSREADCSGELSVSNASDMESEWVEQDEPGVYITIRALPGGNRELRRVRFSRERFGEMQARLWWEANRARIQEQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNF7</accession>
    <name>A0A068TNF7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021805001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNF7"/>
    <dbReference type="Gramene" id="CDO97870">
        <property type="protein sequence ID" value="CDO97870"/>
        <property type="gene ID" value="GSCOC_T00021805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="111" mass="12637" checksum="9136E9D62BB0BB23" modified="2014-10-01" version="1">MTGPPLLTREPYPHSHLVPAGNVGRSGHQNDRSRAVNGHDLSSINCAIQITNYVSIFIWCVILIKFYNKIIHYTNKVTQCHCQGSDLPYVFSCSKYMQIIIQEKFVIARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQR0</accession>
    <name>A0A068TQR0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00022442001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQR0"/>
    <dbReference type="FunCoup" id="A0A068TQR0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQR0"/>
    <dbReference type="Gramene" id="CDO98372">
        <property type="protein sequence ID" value="CDO98372"/>
        <property type="gene ID" value="GSCOC_T00022442001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQR0"/>
    <dbReference type="OMA" id="FIIYPRM"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQR0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF292">
        <property type="entry name" value="LACCASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103898" description="Laccase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="159"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="426"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDO98372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="577" mass="64731" checksum="1C18C735B405398D" modified="2014-10-01" version="1">MGSFYHQIFVTLVLLLSIFLPCSLSSTTRRFEFNVKWKNVKRLCNTRPVLTVNGEYPGPTISVHEGDNVEVKVTNRVDMNTTLHWHGIRQLRTGWADGPAYVTQCPIGTGKSYTYRFTVVDQRGTLWWHAHLSWQRSTVNGAFIIYPRMPYPFSVPIQEEIPITFGEWFNSDVMAIEKDMMLTGVGPNASDAYTINGLPGPLYNCSLKDTFIKTVEHGKTYLLRIINAALNDELFFAVADHTLTVVEIDAVYTKPFTTKAIMIAPGQTTNVLLTANQKPDSTGMFVLAARPYLTSIFPFDNSTTIGFLKYKTTKSKETVELPLPPYTLPSNLPALQDTEFATEFAKQLRSLGSAQYPCKVPKKVHKQVITTIGLNLQECTPNKTCKGFRNQRFLASMNNQSFIRPPISILECHYKNLSMANLFSNFPEKPPVPFNYTGVNPLTENMNAEFGSKLVVVPYGTRLEIVLQDTNFLNPENHPIHVHGHNFFIVGRGFGNFDAEKDPLHYNLVDPPERNTVAVPIGGWAALRIHADNPGVWFIHCHLEEHTTWGLAMGLVVQGGKNPSQCLIPPPDDLPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQZ4</accession>
    <name>A0A068TQZ4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00025602001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQZ4"/>
    <dbReference type="FunCoup" id="A0A068TQZ4">
        <property type="interactions" value="685"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98705">
        <property type="protein sequence ID" value="CDO98705"/>
        <property type="gene ID" value="GSCOC_T00025602001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQZ4"/>
    <dbReference type="OMA" id="WIGFNSA"/>
    <dbReference type="OrthoDB" id="368507at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQZ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="137" mass="14541" checksum="40422A9C30CABBA0" modified="2014-10-01" version="1">MPPSTFTSSVFTSRQDFFLSFFLSLYFFQTSIAQTILIYAWIGCNSAKFGHLYAAAPTRPSNAVSVTSLIGGSSDNAGAGIARRIVLKTGLNVVLACNLPKNSPLLEAAAERRLVQKLVSLGYATPKSGVSSSTQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRV8</accession>
    <name>A0A068TRV8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025646001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRV8"/>
    <dbReference type="Gramene" id="CDO98742">
        <property type="protein sequence ID" value="CDO98742"/>
        <property type="gene ID" value="GSCOC_T00025646001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRV8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="58" mass="6847" checksum="782C5D8DD53A90BD" modified="2014-10-01" version="1">MATLRCCASVQLHGTRECFKTFGRKAREGRESEDRQIYDDDQNNFFFFCAINYVTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TS61</accession>
    <name>A0A068TS61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00025836001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TS61"/>
    <dbReference type="Gramene" id="CDO98882">
        <property type="protein sequence ID" value="CDO98882"/>
        <property type="gene ID" value="GSCOC_T00025836001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TS61"/>
    <dbReference type="OMA" id="MGGPSYY"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TS61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45868:SF80">
        <property type="entry name" value="F15K9.8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45868">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="314" mass="33571" checksum="B7C3510C6C52A251" modified="2014-10-01" version="1">MEEPLQYQTWALKVSIHCQGCKTKVKKVLQSIEGVYAVAIDSQHKVTVTGNIDAQTLIRKLLKTGKHAELWPEKPAGKDKKSGKSSSNEKGGDSKNGENSEEEEEESPAGNMEANVNPAKNSEKGTKVVRFAGVDGIAGDQREIKIDGKLPGSIPATAEKSPASEQKSNANNGGGAEKNNGGAGGHGKKKKKKGKKGNSNNNSNAGSASALAPSSTGVEGPRVMSPNQATDQINLTPSNQHMFQYPPSYSPYQAYVVSYNAAHPTTCTGPIWYMSPSPYLYACTYPEVYPEYPTPALSTFEILSDENPNGCYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT26</accession>
    <name>A0A068TT26_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00022622001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
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        <property type="protein sequence ID" value="CDO98503"/>
        <property type="gene ID" value="GSCOC_T00022622001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TT26"/>
    <dbReference type="OMA" id="RCMMSHR"/>
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        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010090">
        <property type="term" value="P:trichome morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF42">
        <property type="entry name" value="ENOLASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="enolase"/>
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        <property type="entry name" value="Enolase"/>
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    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="8">
        <location>
            <begin position="200"/>
            <end position="490"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO98503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="490" mass="52234" checksum="A7A5C3500BFC0167" modified="2014-10-01" version="1">MALAPTPLSKPFFSTKPTSQTPLFTLPATRKVHTRPNSVVRSSIATAPAAATVSKASAKVKSVKARQIIDSRGNPTVEVDLVTDGADGQLYRSAVPSGASTGIYEALELRDGDKSVYGGKGVLNAVKNINDILGPQLVGVDVRNQADVDAIMLEIDGTTNKSKLGANAILGVSLSVCRAGAGAKGIALYKHIQELSGTKELVMPVPAFNVINGGSHAGNNLAMQEFMILPVGATSFAEALRMGSEVYHTLKGIIKAKYGQDACNVGDEGGFAPNVQDNREGLVLLMDAIEKAGYTGKIKIGMDVAASEFLTKDGKYDLNFKKQPNDGAHVLTDQSLCELYKEFVKDFPIVSIEDPFDQDDWKSWASLQSSVDIQLVGDDLLVTNPKRIAEAIQKKACNALLLKVNQIGSVTESIQAALDSKTAGWGVMVSHRSGETEDHFIADLSVGLASGQIKTGAPCRSERLAKYNQLLRIEEELGNVRYAGEAFRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVG0</accession>
    <name>A0A068TVG0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SS18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029699001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Gramene" id="CDO99964">
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        <property type="gene ID" value="GSCOC_T00029699001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVG0"/>
    <dbReference type="OMA" id="ENAHPGA"/>
    <dbReference type="OrthoDB" id="10265171at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVG0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009955">
        <property type="term" value="P:adaxial/abaxial pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048825">
        <property type="term" value="P:cotyledon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010449">
        <property type="term" value="P:root meristem growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="227" mass="23787" checksum="2AE2E4A0F8C45311" modified="2014-10-01" version="1">MQQHLMQMQPMMAAYYPSNVTTDHIQQFLDENKSLILKIVESQNSGKLSECAENQAKLQRNLMYLAAIADSQPQPPAMHSQQFPPVGIVQPGAHYLQHQQAQQMTPQSLMAARSSMLYGQQPFSALQQQQALHSQLGMSPGGSSGIHILQGEAHGAGSSGVLGGGGFPDFGRGTAGEALQVAARGMGSGSKHDLGGAMSAEGRGGSSGGHNGDAGETLYLKSADDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW66</accession>
    <name>A0A068TW66_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029230001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW66"/>
    <dbReference type="FunCoup" id="A0A068TW66">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TW66"/>
    <dbReference type="Gramene" id="CDO99593">
        <property type="protein sequence ID" value="CDO99593"/>
        <property type="gene ID" value="GSCOC_T00029230001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW66"/>
    <dbReference type="OMA" id="MMNNDWM"/>
    <dbReference type="OrthoDB" id="2020598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040265">
        <property type="entry name" value="CHUP1/IPGA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
        <property type="entry name" value="PROTEIN CHUP1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342:SF16">
        <property type="entry name" value="TALIN_MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="678"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="88375" checksum="07306D7A1C621858" modified="2014-10-01" version="1">MKNTAVVKSRGVAGNFVKMTDIRTKVLTFRDLLDLSPCIGSASVNELLIWTLQDLHRLYPSLKPSIPVSEIERASTDQVLRCFCDFLKSLGDSWINNGEWMVKCKYDASIKLNQNDLEDIAQSMLEDMNKLARERMFDMMDEDEQMNGYSPSETAFGKALSESYSDSKNSLSSSPATPTSVLQDMTNMLSKGTKQSYTPPLLLQLRVQAVEKLNPIDIKRLSFHMLPHAAAPDPNYPLQKSKHESVSKAAGTNEVNQDFEMEEDTFDVVMTNSDESAIEAGKTRTTIENLVTGPVPCTPAKGDIDVVPPPTSLPKLRSNVSEKENTPQIPVEYKLPLDKIASQGSAAPPPPPPPPPQMFPKNEVLLARQCQTQLLETICPTPPPPPPIPSPIAEGSIAITPPPPPPPPLPPVTSMSTTFFPPPPPPPPPPSTSNIPGSIAPPPPPPPPSSMPSGNFTFHPPPPPPPMGSGKIAPPPPPPPMGASNGGVPAPPPPMQPGMRGPPPPPPGLGGAKDPRLRKAATKLKRSSQMGNLYRLLKLKVEGGSNLDAKSSRKGKISSTSGGQQGMADALAEMTKRSAYFQQIEEDFKNHEKSIRELKVSINSFQCSDMTELHKFHKHVESILEKLTDETQVLARFEDFPTKKLEALRMAAALYSKLDTIITTLKNWQIESPVGPVIDKIEKYFSKIKQELDALERTKDEESKKFQSHKINFDFGILVRIKELMVDVSSSCMEQALKERRDAKAMENAQKGPKTECPKKRSGKMLWKAFQFAYRVYTFAGGHDDRADQLTRELASEIQTDPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY72</accession>
    <name>A0A068TY72_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peamaclein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00034803001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY72"/>
    <dbReference type="FunCoup" id="A0A068TY72">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TY72"/>
    <dbReference type="Gramene" id="CDP01230">
        <property type="protein sequence ID" value="CDP01230"/>
        <property type="gene ID" value="GSCOC_T00034803001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY72"/>
    <dbReference type="OMA" id="CGICCAQ"/>
    <dbReference type="OrthoDB" id="847210at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF141">
        <property type="entry name" value="GIBBERELLIN-REGULATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654386" description="Peamaclein-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9668" checksum="BE0F241DADFB8EC4" modified="2014-10-01" version="1">MKLVFFTLLLLALVLNSSFIPATMAGSSFCDSKCGVRCSKAGVQDRCLKYCKICCQECNCVPSGTYGNKHECPCYRDKKNSKGKPKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYW8</accession>
    <name>A0A068TYW8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 22">Peroxidase</fullName>
            <ecNumber evidence="5 22">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00036573001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19 22">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="19 22">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19 22">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="19 22">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 22">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="5 22"/>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYW8"/>
    <dbReference type="FunCoup" id="A0A068TYW8">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYW8"/>
    <dbReference type="Gramene" id="CDP01500">
        <property type="protein sequence ID" value="CDP01500"/>
        <property type="gene ID" value="GSCOC_T00036573001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYW8"/>
    <dbReference type="OMA" id="TFPQTRK"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYW8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068U0X7">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0X7"/>
    <dbReference type="Gramene" id="CDP01987">
        <property type="protein sequence ID" value="CDP01987"/>
        <property type="gene ID" value="GSCOC_T00037188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0X7"/>
    <dbReference type="OMA" id="VEATLNW"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0X7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF40">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE EPSILON 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="4">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="231" mass="25284" checksum="C3FC8C65127983AB" modified="2014-10-01" version="1">MTEPSRFRPGDDPGDGGTLGALEEEAFVDGSSGPAASGLEAIVNNLSKWLTAVLFGIFLLVRHDAAALWAAWGSVMNMAMGIMLKRLLNQERPVSNLRSDPGMPSSHALSISYITTYIILSVIQYWGLNGITAAISGIFLSIGSYFSWLRVSQQLHTISQVVVGALLGTVFSTLWFWAWSSIVLKAYVSNLWVQIVVTLGGAAFCTVFILHVIRYWVMEPLTLYMSRKFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U166</accession>
    <name>A0A068U166_COFCA</name>
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        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00034961001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U166"/>
    <dbReference type="STRING" id="49390.A0A068U166"/>
    <dbReference type="Gramene" id="CDP01353">
        <property type="protein sequence ID" value="CDP01353"/>
        <property type="gene ID" value="GSCOC_T00034961001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U166"/>
    <dbReference type="OMA" id="KHEMTID"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U166"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="9269" checksum="071750DB217F25C3" modified="2014-10-01" version="1">MSLEEFKEWLKKFDSNGDGRISKEELRQAIRAKGGWFTRWKCKDGLKSADKDGNGFIEDDEMSYLKDFALKHLGIKIVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U244</accession>
    <name>A0A068U244_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00039532001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U244"/>
    <dbReference type="FunCoup" id="A0A068U244">
        <property type="interactions" value="3326"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U244"/>
    <dbReference type="Gramene" id="CDP02209">
        <property type="protein sequence ID" value="CDP02209"/>
        <property type="gene ID" value="GSCOC_T00039532001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U244"/>
    <dbReference type="OMA" id="MMYCHAI"/>
    <dbReference type="OrthoDB" id="933152at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U244"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000204">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="119" mass="13624" checksum="BBE9FAFD1C413607" modified="2014-10-01" version="1">MLWNAVIFGPDDTPWDGGTFKLTLQFTEDYPNKPPTVRFISRMFHPNIYADGSICLDILQNQWSPIYDVAAILTSIQSLLCDPNPNSPANSEAARLFSENKREYNRKVREIVEQSWTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2A5</accession>
    <name>A0A068U2A5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039654001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2A5"/>
    <dbReference type="FunCoup" id="A0A068U2A5">
        <property type="interactions" value="1009"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2A5"/>
    <dbReference type="Gramene" id="CDP02299">
        <property type="protein sequence ID" value="CDP02299"/>
        <property type="gene ID" value="GSCOC_T00039654001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2A5"/>
    <dbReference type="OMA" id="RDNERKH"/>
    <dbReference type="OrthoDB" id="1100735at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2A5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040400">
        <property type="entry name" value="BAG5/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33322">
        <property type="entry name" value="BAG DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33322:SF18">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 8, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50072" checksum="756C82F873DCF96A" modified="2014-10-01" version="1">MAAHHQQQLHHCHPTTTSTVCFCYYCCPNYTSSHLHPVSDPHPLHHLHHPPQTYYSPYGDGSNPNPPSTTQSGHHHHHQGPHYRPPPTDPEIERYFHHDQQRELTHTHPIVCSLLRRIAALESSLRHHSSSHSHSLRDSAARIIQTHFRAFLVRRSRTLRQLKDLASIKSTFNTLKSSVSKNPHLDPQLLFRKALGLLFKLDSVQGGDPMIRDGKKSISRELTGFLDLIDGVTVKKSEISAKLVTKNAPRKCGVLYNEHKSGTFACRNLAKNKRLEDLVDRIDALSTKVPIGDIAVDEEDLEIPGISRNRAARSGHPSDGLGAKVKKSVSFVENGKVYRIHRKGFEPVPAGDCDSSGDESYSVGAEGELKDDIRRKAEEVGEISFKDTLAEEEDESQDVESSKSSDGVEGPGYELRNEDGGFTFSAPLPMKMETKADIMDRRKGVKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U383</accession>
    <name>A0A068U383_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oleosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00039354001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the oleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U383"/>
    <dbReference type="FunCoup" id="A0A068U383">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U383"/>
    <dbReference type="Gramene" id="CDP02073">
        <property type="protein sequence ID" value="CDP02073"/>
        <property type="gene ID" value="GSCOC_T00039354001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U383"/>
    <dbReference type="OMA" id="SWVTNYL"/>
    <dbReference type="OrthoDB" id="1929188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U383"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012511">
        <property type="term" value="C:monolayer-surrounded lipid storage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050826">
        <property type="term" value="P:response to freezing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010344">
        <property type="term" value="P:seed oilbody biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000136">
        <property type="entry name" value="Oleosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33203">
        <property type="entry name" value="OLEOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33203:SF44">
        <property type="entry name" value="OLEOSIN 20.3 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01277">
        <property type="entry name" value="Oleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP02073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17837" checksum="996F8435EB29A248" modified="2014-10-01" version="1">MADRDRSPPQQLQVHHQHLGYGEGGVKTLFPQTGPSAIQVLAVVTLLPVGGTLFGLAGLTLVGTLIGLALTTPLFVICSPVLVPAVVLFGLAVTGFLSSGAFGLMGLSSLSWVLNCFRQKATEQMDDARRRMQEAAGQLGQKTKEVGERIQTKAQEPTGRDQGGREAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3X2</accession>
    <name>A0A068U3X2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00041503001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3X2"/>
    <dbReference type="FunCoup" id="A0A068U3X2">
        <property type="interactions" value="3152"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3X2"/>
    <dbReference type="Gramene" id="CDP03032">
        <property type="protein sequence ID" value="CDP03032"/>
        <property type="gene ID" value="GSCOC_T00041503001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3X2"/>
    <dbReference type="OMA" id="TNERKPR"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3X2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF25">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHATASE SAC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="199"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP03032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="877" mass="99909" checksum="568AB257777B9E2E" modified="2014-10-01" version="1">MAEELENEQPPPQQQQQLTSYSENDHTYAENDQHQTENDQGTAGECYPGRPNPLPEGFMQKFRLYETGSNYYMIGRDKSRTCWRVLKINRLEAYELNILEDSTTYTERECSDLLRRIHEGNMSTGGLRFVTTCYGIVGFIKFLGPYYMLVITKRRQIGAISGHNVYAISKSEIIPLPNSAVRSSMMIDYRNENRYKRLLCTVDLTKDFFFSYSYHVMRSVQKNICDAETGNVLYETMFVWNEFLTRGIRNILQNTLWTVALVYGFFQQATLSISGRQFRLTLIARRSRHYAGTRYLKRGVNERGRVANDVETEQIVFENVPEGIPIQISSVVQNRGSIPLFWSQETSRLNLKPDIILSKKDQRYEATRLHFENLVGRYGHPIIILNLIKTSEKKPRESILRAEFANAIEYINKDLSEENHLKFLHWDLHKHSRSKATNVLLLLGKVATYALTLTGFFYCQVTPALATEGCLKWPYFESSVDSDTQQPVQCEIENESNDNHHDDASENLDRFDRRLCTGNNVANGGGFGKPPILQKGVLRTNCIDCLDRTNVAQYAYGLAALGHQLRALGIINSTKIDLDDPLADELMGFYERMGDTLAHQYGGSAAHNKIFSQRRGQWKAATQSQEFFRTLQRYYSNAYMDAEKQNAINVFLGHFQPQPGKPEVWELNSDQLYRESRNGQSKIDKNGRSLFKRSLSDGNILRETYTPVSTSNMSKDISNSLPDTPEGGSNILSESTPNIPTCENELSHLRYTPSMPVRELFEDLPRDRCQENENGDSYDCSNFVDLDWLSSSGNSCEEEILERSLLTSPIAGLSSDNVVSDLAGEATPAISECGSSMKGRDQTGTELCYDDSYGSEVHEEFSDCFVHWVTYGETLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U471</accession>
    <name>A0A068U471_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="8">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00041397001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Extracellular space</location>
            <location evidence="8">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="8"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U471"/>
    <dbReference type="STRING" id="49390.A0A068U471"/>
    <dbReference type="Gramene" id="CDP02959">
        <property type="protein sequence ID" value="CDP02959"/>
        <property type="gene ID" value="GSCOC_T00041397001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U471"/>
    <dbReference type="OMA" id="ESAWDEI"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U471"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104017" description="Xyloglucan endotransglucosylase/hydrolase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP02959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="265" mass="30038" checksum="9BC762BE73B03FA6" modified="2014-10-01" version="1">MASSSWNLTPIVFVLLSLSVSSALANFYNNIDVTWGDGRARILNNGDLLTLSLDKTSGSGFQSKNEYLFGKIDMQLKLVPGNSAGTVTAYYLSSQGPTHDEIDYEFLGNLSGDPYILHTNVYAQGKGGREQQFYLWFDPTADFHTYSILWNPQRIIFSVDGTPIREYKNPESLGVPYPKNQPMKMYSSLWNADDWATRGGLVKTDWSRAPFTASYRNLNQNACIWSSGKSSQQRLQWVRKNYMIYNYCTDTKRFPQGFPAECSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4P2</accession>
    <name>A0A068U4P2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00015292001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4P2"/>
    <dbReference type="STRING" id="49390.A0A068U4P2"/>
    <dbReference type="Gramene" id="CDP03486">
        <property type="protein sequence ID" value="CDP03486"/>
        <property type="gene ID" value="GSCOC_T00015292001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4P2"/>
    <dbReference type="OMA" id="IAMMRFF"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4P2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000206">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="257" mass="29449" checksum="11561068D9298862" modified="2014-10-01" version="1">MDTDLHQIIKSSQTLTNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTNNDKGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPIFPGTECLDQLRLIINILGSQKEDDIEFIDNPKARKYIRTLPYSPGTPFSRLYPHAHPLAIDLLQKMLVFDPTKRISVTEALQHPYMAPLYDPSCDPPAQVPINLDIDEDLGEEMIREMMWTEILHYHPEAALADLEVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4W2</accession>
    <name>A0A068U4W2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CSC1-like protein At4g02900</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00016015001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4W2"/>
    <dbReference type="FunCoup" id="A0A068U4W2">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP03600">
        <property type="protein sequence ID" value="CDP03600"/>
        <property type="gene ID" value="GSCOC_T00016015001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4W2"/>
    <dbReference type="OMA" id="VVCAWAF"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4W2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF96">
        <property type="entry name" value="OS05G0393800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="198"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="371"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="86013" checksum="602291BDD761FAF8" modified="2014-10-01" version="1">MASVSDISVSAAINLLSALAFLLAFAFLRLQPINDRVYFPKWYLKGIRASPRSSGPFMKKFVNLDIRMYLKFWTWMPAALRMPQPELIDHAGLDSAVYIRIYLLGLKIFVPIAILGFAVLVPVNWTGKTLEHIHNLTFSNIDKLSISNVPSGSERLWAHLLMAYTFSFWTCYVLYKEFKIVSTLRLHFLASEGRRPDQFTVLVRNVPPDPDESVSEHVEHFFCVNHPDHYLSHQVVYNANKLAKLVEKKKSCQNWHTYYQTKYERNPKKKPTTKTGFWGLWGKTVDAIDYYTAEIEKLSEEEATERERVMSDPKAIIPAAFVSFKSRWGAAVCAQTQQSSNPTIWLTEWAPEPRDVHWANLAIPYVGLTIRRLLVAVVLFFLTFFFMIPIAFVQSMANIEGIEKVLPFLKPLIEAKTVKSVIQGFLPGIALKIFLILLPTILVTMSKIEGFTSLSSLDRRSAAKYHLFLLVNVFFGSIITGAAFEQLQSFLKQAPTEIPKTAGVAIPMKATFFITYIMVDGWAGIAAEILRLVPLVMFHLKNTFLVKTEQDREDAMDPGSINFSTSEPRIQLYFLLGLVYSVVTPILLPFIIIFFAFAYVVFRHQIINVYDQKYESGAKFWPDVHRRIIVALVISQLLLMGLLSTKKAANSTPLLIVLPVLTIWFHLFCKGRFESAFVKFPLQDAMVKDTLERATEPNLNLKAYLHDAYIHPVFKCVQLDKPKAVDDEENNPLVATKRNSRRDSKTGSDGIPETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8J0</accession>
    <name>A0A068U8J0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00018625001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8J0"/>
    <dbReference type="FunCoup" id="A0A068U8J0">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8J0"/>
    <dbReference type="Gramene" id="CDP04617">
        <property type="protein sequence ID" value="CDP04617"/>
        <property type="gene ID" value="GSCOC_T00018625001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8J0"/>
    <dbReference type="OMA" id="DLPTSKC"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8J0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05476">
        <property type="entry name" value="pepsin_A_like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000029">
        <property type="entry name" value="Aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000016">
        <property type="entry name" value="Probable aspartic protease At2g35615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034161">
        <property type="entry name" value="Pepsin-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051708">
        <property type="entry name" value="Plant_Aspart_Prot_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967:SF23">
        <property type="entry name" value="OS04G0448300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967">
        <property type="entry name" value="OS07G0603500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="102"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP04617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="445" mass="47509" checksum="842E1C360F16E717" modified="2014-10-01" version="1">MASFQQAFSSVVLVVLAVAILFVTPTFSTSRNAIMKDEKVQKATGFQVTLKHVDSGSNLTKFELLQRAMKRGRQRLNRLSAMALAESDHDVKSSVHPGNGEFLMQFSIGTPSTAYSGIMDTGSDLIWTQCKPCQQCFDQSTPIFDPRKSSSFSTLSCSSSLCEALPMSSCGTDGCEYLYTYGDYSTTQGVMAAETFTFGEVSVPKVAFGCGEDNEGSGFGQGAGLVGLGRGPLSLVSQLDEPKFSYCLTSIDDSSTSTLLMGSLANANNSDTASKTTPLVVNPSQPSFYYLSLEGITVGGTRLPIKKSTFALNSDGSGGVIIDSGTTLTYLEKSAFDLVKKEFTSQMKLPVDKSGSSGLDLCFTLPSDASDIEVPKLVFHFKGADVDLPGENYMIADSSVGLACLAMGSSSGMSIFGNVQQQNYLLLHDLQKETLSFIPTKCNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9V2</accession>
    <name>A0A068U9V2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00020001001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9V2"/>
    <dbReference type="FunCoup" id="A0A068U9V2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9V2"/>
    <dbReference type="Gramene" id="CDP05077">
        <property type="protein sequence ID" value="CDP05077"/>
        <property type="gene ID" value="GSCOC_T00020001001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9V2"/>
    <dbReference type="OMA" id="PECGHCF"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9V2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046948">
        <property type="entry name" value="ATL20-22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279:SF10">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654611" description="RING-type domain-containing protein" evidence="19">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDP05077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="384" mass="41876" checksum="58D26EAF292873B3" modified="2014-10-01" version="1">MQQKLIALLLISASSLIVLVVSSPEICTVSACYPNEPTIRFPFRLQSVQPKECGYPGFDLTCDSTILITSLQLQNVNASPPQRFSVQAIDYASQEIWLNDPGDCLPQRLLNLNLSGSPFTAVSHQDFTLFNCSIHHRLHNFNPIACLGGSGYNIVATSSERASRILASSCSVVSTIPVPVQLPYHEEVWSSDLSEDIRLTWDSPHCGKCESRGGRCGLKSNSTDHIECKTQHAGLPRGARYAISVGAGVPTLLFVIGLVCFVCGRLKACRRQPYPVIEFSSTVARQPTLLSGLDGAIIESYPKTVLGESRRLPKPNDTVCPICLSDYKPKDTLRTIPACQHCFHADCIDEWLRLNAACPVCRNNPKQSPPALEPASAPASDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAZ7</accession>
    <name>A0A068UAZ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019541001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAZ7"/>
    <dbReference type="STRING" id="49390.A0A068UAZ7"/>
    <dbReference type="Gramene" id="CDP04813">
        <property type="protein sequence ID" value="CDP04813"/>
        <property type="gene ID" value="GSCOC_T00019541001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAZ7"/>
    <dbReference type="PhylomeDB" id="A0A068UAZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="98" mass="10477" checksum="3728BE025E9D706A" modified="2014-10-01" version="1">MKGWQNNRKPKAVVVGGSIAGISCAHALINAGWDVVVLEKTCAPPSGSPTGAGLGLDPLAQQIIQTWLRQPELLHNSTLPLSIDQLNAKFLKRVTHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCC1</accession>
    <name>A0A068UCC1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00021576001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCC1"/>
    <dbReference type="STRING" id="49390.A0A068UCC1"/>
    <dbReference type="Gramene" id="CDP06175">
        <property type="protein sequence ID" value="CDP06175"/>
        <property type="gene ID" value="GSCOC_T00021576001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCC1"/>
    <dbReference type="OMA" id="IMPREKY"/>
    <dbReference type="OrthoDB" id="1854593at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCC1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090447">
        <property type="term" value="F:glycerol-3-phosphate 2-O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010143">
        <property type="term" value="P:cutin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06551">
        <property type="entry name" value="LPLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056462">
        <property type="entry name" value="HAD_RAM2/GPAT1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486">
        <property type="entry name" value="ANCIENT UBIQUITOUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23270">
        <property type="entry name" value="HAD_RAM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="9">
        <location>
            <begin position="283"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="484" mass="54359" checksum="E88F12D70B0B187B" modified="2014-10-01" version="1">MESMNEVSSYPSVTECTLDSRGSQKLVCDIITLLRSDHSFFPYFLLVAFEGGSILRAFLVMIFITFCGLRLRDMAVVARAVLPKFYLENINLLVYEVFASAGSRLVFTSVPRVMVEGFLKEYLSVETVKGTELHTIGPFFTGLVSSSGLLVKARALKESCGENLPDIGVGSLDHHDHQFVSLCKEAYVVHKDDRKACESTIMPRERYPRPLIFHDGRLAFFPTPLATLTMFIWLPFGIILVIFRFSVALLLPCKMAKFLILATGGKLKLRLSEPLGSESEKKVLYVCNHRTLMDPVVLFGALEKPLTAVTYSLSKFSEMVSPIRTVRLTRDRNQDAKTIQKLLSGGDLVICPEGTTCREPYLLRFSSLFAELTDEIVPVAMDTYTSMFYGTTVSGYKWLDSIFLGMNPNPCYSIYVLEKLPKEITFSVGKSSHEVANYIQRRLGDALGFQCTNLTRRDKYTMLAGNEGLVQDYRKKASEHSQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCD2</accession>
    <name>A0A068UCD2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00021162001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCD2"/>
    <dbReference type="FunCoup" id="A0A068UCD2">
        <property type="interactions" value="2118"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCD2"/>
    <dbReference type="Gramene" id="CDP05859">
        <property type="protein sequence ID" value="CDP05859"/>
        <property type="gene ID" value="GSCOC_T00021162001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCD2"/>
    <dbReference type="OMA" id="RSSFEQH"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCD2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044520">
        <property type="entry name" value="ARF_GAP_AGD5/15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP05859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="471" mass="50883" checksum="24382FF42B9E4DB2" modified="2014-10-01" version="1">MNEKANVSKELNARHRKILEGLLKLPENRECADCKTKGPRWASVNLGIFICMQCSGIHRSLGVHISKVRSATLDTWLPEQVAFIQSMGNEKSNSYWEAELPPNYDRVGIENFIRAKYEEKRWVPKDGKPNSPARGREDKLSAQWQRPNDRNVPAYTGHSRTSSDERKSIQTSSTKENVAAGGISIPVPPKAQEPVVPAPVPQQVIQKTESVASESVKQVAQAASPPKVDYAMDLFNMLSMDTPSENGSGAASADDNSWAGFQSAQETSTAEGSVPSKVNDNKKQSANEIEDLFKDTASIAPLMTEKPEKDVKNDIMSLFDKSNMVSPFASHQQQIAMMSQQQSLLMAAAAANAAGGLLKVPGNMQQGPNGINLLNHNLASAGYHQFYGMMMPGAGKNECMQMGNLGNAQLVGSTAQFPATSVYPVGQSTSSNGVVTPGVSRQTASPVSSSSTQTAKEYDFSSLTQGLFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCE8</accession>
    <name>A0A068UCE8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00021559001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCE8"/>
    <dbReference type="STRING" id="49390.A0A068UCE8"/>
    <dbReference type="Gramene" id="CDP06161">
        <property type="protein sequence ID" value="CDP06161"/>
        <property type="gene ID" value="GSCOC_T00021559001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCE8"/>
    <dbReference type="OMA" id="NHQCPAT"/>
    <dbReference type="OrthoDB" id="1936515at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCE8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF358">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP06161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="37498" checksum="A00B6AFAD7EB342E" modified="2014-10-01" version="1">MSDHHRNDGYHYGTNSFYHDYMGTGGSTSTFPFFGGGNSLMYNQPSTSQNLAGSSSAYDPTSYMSFTDCLQGTAADYNNLSGAFDMSCNSLPDQSVCPVDNSSSDKNTTSLGEAAAGAATTSAENPRTPVSSLSCSSNETGVEEESSKSNTTDLQTKGSEDRDDKSKKLNKPKKKGEKKPREPRFAFLTKSDIDHLEDGYRWRKYGQKAVKNSPFPRSYYRCTSQKCIVKKRVERSFQDSSIVITTYEGQHNHHCPATLRGNAAAMLSPSFLSSNSASLPTFPPEFITHMLPSTSRNYQNPPYYQNFNPQDQQFQLPHDYTNFFQDMNPSFMHKPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCH9</accession>
    <name>A0A068UCH9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00021326001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCH9"/>
    <dbReference type="FunCoup" id="A0A068UCH9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCH9"/>
    <dbReference type="Gramene" id="CDP05987">
        <property type="protein sequence ID" value="CDP05987"/>
        <property type="gene ID" value="GSCOC_T00021326001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCH9"/>
    <dbReference type="OMA" id="LWSWEWR"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCH9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990538">
        <property type="term" value="F:xylan O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF217">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="7">
        <location>
            <begin position="124"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="419" mass="48512" checksum="F705C94A55885530" modified="2014-10-01" version="1">MTTQPIQYHRRMQLVFPVALASLLVLGAVRVALDSLKNNELYFLWQSRLAGSRGPGLPIIVSEDEVIEDGCNVFEGKWVWDNLSYPLYREDSCPYLVKQVTCLKNGRPDSLYQNWRWQPNGCNLPRFDALKLLEILRDKRLMFIGDSIQRGMFESMVCLVQSVIPEGMKSLKRIPPRKIFVIEEFNASIEYYWAPFIVESISDHATNHTVLKRMVRLDSIAKHSKEWEGVDILVFESYVWWMYKPLINATYGSPDDVREYNVTTAYKLAMETWANWIETGINPRNQKIFFMTMSPTHLWNWEWKAGSDGNCFNESHPIEGPYWGTGSNLDIMGSVKDVLGKLKVNVRLLNITQLSEYRKDGHTSVFGERKGKLLTKEQRSDPKTYADCIHWCLPGIPDVWNEIFYAVLLQDYRNNSGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCS4</accession>
    <name>A0A068UCS4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00021426001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCS4"/>
    <dbReference type="FunCoup" id="A0A068UCS4">
        <property type="interactions" value="1990"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCS4"/>
    <dbReference type="Gramene" id="CDP06067">
        <property type="protein sequence ID" value="CDP06067"/>
        <property type="gene ID" value="GSCOC_T00021426001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCS4"/>
    <dbReference type="OMA" id="ERTANYH"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCS4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="195" mass="20465" checksum="3FC98461060BD9C1" modified="2014-10-01" version="1">MSCWPNILSDKSLEVVKNAGILLLQREIPDSVNIQVAKAAQSAGVSVILDAGGVESPIPPELVAVVDILSPNETELARLTNMPTEDFEQIKQAVGKCHNVGVKQVLVKLGAKGSALFTEGEEPIRQPIISAPKVIDTTGAGDTFTAAFAVALAEGKSQKECLKFAAAAASLCVQVKGAIPSMPERKSVLQLLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCW2</accession>
    <name>A0A068UCW2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ethylene receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">GSCOC_T00021486001</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 21">May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="23">Binds 1 copper ion per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the ethylene receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCW2"/>
    <dbReference type="FunCoup" id="A0A068UCW2">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCW2"/>
    <dbReference type="Gramene" id="CDP06102">
        <property type="protein sequence ID" value="CDP06102"/>
        <property type="gene ID" value="GSCOC_T00021486001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCW2"/>
    <dbReference type="OMA" id="YENEYRF"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCW2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051740">
        <property type="term" value="F:ethylene binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038199">
        <property type="term" value="F:ethylene receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010105">
        <property type="term" value="P:negative regulation of ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19933">
        <property type="entry name" value="REC_ETR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000192">
        <property type="entry name" value="Ethylene receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000030">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000026">
        <property type="entry name" value="Ethylene response sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014525">
        <property type="entry name" value="ETR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058544">
        <property type="entry name" value="ETR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24423:SF615">
        <property type="entry name" value="ETHYLENE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24423">
        <property type="entry name" value="TWO-COMPONENT SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25487">
        <property type="entry name" value="ETR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026389">
        <property type="entry name" value="Ethyln_sen_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 21 23" id="KW-0186">Copper</keyword>
    <keyword evidence="19 24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="12 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="18 21 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 21 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 26" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17 21" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="28">
        <location>
            <begin position="349"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="29">
        <location>
            <begin position="614"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="469"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="26">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="24">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="24">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="25">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR026389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR026389-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CDP06102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="740" mass="82505" checksum="896FD23E71E461EF" modified="2014-10-01" version="1">MESCNCIEPQWPADELLMRYQYISDFFIALAYFSIPLELIYFVKKSAVFPYRWVLVQFGAFIVLCGATHLINLWTFTMHSRTVAIVMTAAKVLTAAVSCATALMLVHIIPDLLSVKTRELFLKNKAAELDREMGLIRTQEETGRHVRMLTHEIRSTLDRHTILKTTLVELGRTLGLEECALWMPTRSGVELQLSYTLHHQNPVGFTVPIQLPVINQVFSTNRAVKISPNSPVAKLRPSGKYMQGEVVAVRVPLLHLSNFQINDWPELSTKRYALMVLMLPSDSARQWHVHELELVEVVADQVAVALSHAAILEESMRARDLLMDQNVALDLARREAETAVRARNDFLAVMNHEMRTPMHAIIALSSLLQETELTPEQRLMVETILKSSNLLATLINDVLDLSRLEDGSLQLDIEPFDLHGLFKEVINLIKPIASVKKLFVTLSMSSDLPEYAIGDEKRLMQIMLNVVGNAVKFSREGGISISASVAKSDSLRDPRAPDFFPVLSDNHFYLRVQVKDTGSGISPQDIPKLFTKFAQSQSLAAKNSGGSGLGLAICKRFVNLMDGHIWLESEGLGKGCTAIFMVKLGLRGRSNEAKLQYVSRAPVNHVRTNFTGLKVIVMDDNGVSRMVTKGLLVHLGCDVATVSSGDECLKVVNNEHKVVFMDVSIPGIDIYAVAVRIHEKFARRRDRPLIVALTGNTDRVTKESCMRVGMDGVILKPVSVDKMRSVLSELLDHGVLLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDR7</accession>
    <name>A0A068UDR7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023545001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDR7"/>
    <dbReference type="STRING" id="49390.A0A068UDR7"/>
    <dbReference type="Gramene" id="CDP06631">
        <property type="protein sequence ID" value="CDP06631"/>
        <property type="gene ID" value="GSCOC_T00023545001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDR7"/>
    <dbReference type="OMA" id="FNGEVAH"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDR7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509:SF34">
        <property type="entry name" value="F3L24.34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="828" mass="92037" checksum="68ED5A7E8CA238C9" modified="2014-10-01" version="1">MAARVAGRIRALWWVKLQSAFRTALACTIVGCTTLYAPAHFTRQITFPAISYVTAVLIVSDANLGDAIRGCWHAFYATLQMLPLSILGLRIIGPARFSPSIAAAAAALASFLVALPNSTPLMSKRIAFGQIVIVCVNAVIHGKQSSSVVVHPVHVASSTALGAASAFLALLLPYPRLAYYEVRKLSRLYAENAAERINLYMNAFLAENHLNAVELISLAHPLAATGKKLLRTITLMQVTPFCSFSSQEGILWEMPWIRFSKLHFANPGDRLQGMETSMEGMEIALKFCPLSSAGLATQELTDTIRHLSVQLGQKLKQARCFQPFNSTTVPKPKGGCLDNLILPSCDTIPLNNKHLSALFFLSCLEQFLNDSTMVQKPEPNLESLAAEGEELKNSQKHAQISFKETCRKWIGNLRNERLLFASKCSLSLGLAVLIGLIFNKENGYWSGLTIAISFTTRRQAIFTTANARAQGTAVGSVYGVLGCFVFSRLAEIRFVALIPWIIFTSFLRHSRMYGQAGGISAVIGALLVLGRNNYGPPDDFAIARLTEAFIGLCCFILVELLLQPTGASTLVKRHLHLTLGILQECITQVITYSKGKDQASMDLQALKGKQKHLKSYVHEFENLIGQAELEPNFWFLPFRNTSYWKLHNYLSNTADLLHCMAYSLEYLLQVPKNHFALWKDLQEYIHHDLELCKDNLTSSLRCLEKAKMVKSLEVTQEVQQGGMYNDLEKAFFARENSFSTLTTTDQQIRNIVNYLLQRSKKGEHEIKENEGEDGVGEKMALALCSLGFCISGFMREIKDTKSVIKDVVAWETKLNVDSRQTSCKFCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDT9</accession>
    <name>A0A068UDT9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thylakoid membrane protein TERC, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023617001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDT9"/>
    <dbReference type="FunCoup" id="A0A068UDT9">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDT9"/>
    <dbReference type="Gramene" id="CDP06685">
        <property type="protein sequence ID" value="CDP06685"/>
        <property type="gene ID" value="GSCOC_T00023617001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDT9"/>
    <dbReference type="OMA" id="PRRYQHR"/>
    <dbReference type="OrthoDB" id="417520at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDT9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090351">
        <property type="term" value="P:seedling development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238">
        <property type="entry name" value="MEMBRANE BOUND PREDICTED REDOX MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="THYLAKOID MEMBRANE PROTEIN TERC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41434" checksum="67D9CA06F09BFDF1" modified="2014-10-01" version="1">MLELGFLRAPPVPIPPITRPRWVPSLQFTASSSRSHLLFSAGGYNNGRWFYPAIACTRKTQQEESSSISEGETASAPSRNDINDVKKSHNISSDGNSQREAQRPENYVSSVRTVALCVFSAVAFGVALGFKDGVDKASEFFAGYLLEQSLSVDNLFVFVLIFKYFKVPLMYQNRVLSYGIAGAIFFRLSLILLGTATLQRFEVVNLLLAAILLYSAFKLFAEEEEDSDLSDNFIVKTCQKFIPVTSNYDGNRFLTIQDGAWKATPLLLTIAVIELSDIAFAVDSIPAVFGVTRDPFIVFTSNLFAILGLRSLYSLISESMAELDYLQPAIAVVLSFIGFKMILDFFGYHVSTEVSLGFVATSLSAGVLLSLLKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEE3</accession>
    <name>A0A068UEE3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023855001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEE3"/>
    <dbReference type="FunCoup" id="A0A068UEE3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP06841">
        <property type="protein sequence ID" value="CDP06841"/>
        <property type="gene ID" value="GSCOC_T00023855001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEE3"/>
    <dbReference type="OMA" id="AIMKMNA"/>
    <dbReference type="OrthoDB" id="1699369at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEE3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.20:FF:000005">
        <property type="entry name" value="Uncharacterized protein At2g34160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014560">
        <property type="entry name" value="UCP030333_Alba"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31947:SF19">
        <property type="entry name" value="ALBA DNA_RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31947">
        <property type="entry name" value="DNA/RNA-BINDING PROTEIN ALBA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030333">
        <property type="entry name" value="UCP030333_Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="14024" checksum="EC475C18A5728411" modified="2014-10-01" version="1">MTMEAVATNGPAPEQRKNRIQVSNTKKPLFFYVNLAKRYIQQHDEVELSALGMAITTVVTIAEILKNTGLATEKKVLTSTVGMKDESKGRMVQKARIEIVLGKTEKFDALMSAKGPAKGSNSTPDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEQ9</accession>
    <name>A0A068UEQ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023596001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEQ9"/>
    <dbReference type="FunCoup" id="A0A068UEQ9">
        <property type="interactions" value="1936"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEQ9"/>
    <dbReference type="Gramene" id="CDP06669">
        <property type="protein sequence ID" value="CDP06669"/>
        <property type="gene ID" value="GSCOC_T00023596001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEQ9"/>
    <dbReference type="OMA" id="NCCTEET"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEQ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF59">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE PAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="528"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="730" mass="80836" checksum="22B78CF19D0B570D" modified="2014-10-01" version="1">MNVVVKVGSLLTQGVYSVATPFHPFGGAVDIIAVQQQDGSFRSTPWYVRFGKFQGVLKGAEKVVRIEVNGIEANFHMYLDNSGEAYFVREVVSAEDDELNEFNNSEGAWAANYLSSFDVSTLKANSEDVCQTNNDDNISEPPLEGNEGYGSHLNQVEENHETEKQVLDLHYDSSLESTSASMKEEDVFGSCLEIPALAMQVGNSSSHDANSPLEVLEVAKDSQDKSPQRSLSITGSEDLQVPAETIERNTFDTDISGSASMVDDFIHTNGELENEVNVLSRPQASISEEEITISDNVETEKSAYCTDIENETGTSLELSLCRHLLQSGMGLNAAAQAFDAHRISEEEFKVSAASIIKNENLVVRIQGKYLPWDKAAPIVLGMVAYGLQLSIESSDAISLEQDDTRKSREDASGISSTPSGRGWRLWPNPFRRVRRIEHANSNSSNEDAVADSESGSQSQPVEATQTAPDGKESPQKQLMRTNVPTSDQIASLNLKEGQNMVTFTSFSRVLGPQKVEAHIYLWKWNARIVISDVDGTITKSDVLGQFMPLVGKDWTHSGIARLFSAIKENGYQLLFLSARAIVQAYITKSFLINLKQDGNTLPDGPVVISPDGLFPSLYREVIRRAPHEFKIACLEDIKALFPPDYNPFYAGFGNRDTDELSYRKIGIPKGKIFIINPKGEVAINHRIDVKSYTSLHTLVHDMFPPTSLLEQEDYNSWNYWKMPLPEIDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFH7</accession>
    <name>A0A068UFH7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024539001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFH7"/>
    <dbReference type="Gramene" id="CDP07310">
        <property type="protein sequence ID" value="CDP07310"/>
        <property type="gene ID" value="GSCOC_T00024539001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="238" mass="26163" checksum="B4C515B84954E405" modified="2014-10-01" version="1" fragment="single">MLFAHRASASHLVSPASVPCDRPSFFLCVCCICFLPAPFSLQLHLLLPTMLLCHLPACSGACCNILLSSGIRFSQAHSLLTGQGAATFAVGCIGTDLVPFVGLSSSFVVSSLLCLLFSFPVRSDPLFKFPLFIFFPWRSYFFPLSGDVQLSVFLLGYCLLSAQGGAIFAVGCSCPDLLPFVWISSSSFVVIFLLSFSPCYKFPSFFFFFFFAWNSYKRSDSYNQPDQVSTNKKKKGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG48</accession>
    <name>A0A068UG48_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00024732001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG48"/>
    <dbReference type="FunCoup" id="A0A068UG48">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG48"/>
    <dbReference type="Gramene" id="CDP07461">
        <property type="protein sequence ID" value="CDP07461"/>
        <property type="gene ID" value="GSCOC_T00024732001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG48"/>
    <dbReference type="OMA" id="NIFEERY"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG48"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="79"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="289" mass="32873" checksum="6EAE64C67C68ECC7" modified="2014-10-01" version="1">MALPQILPSTSSSIIPSKSHLNPPANSHLNHPLKPFVSSPSAPPPLHHRQWRRRPNLLRCSASSFSEKHHTNSPKSDDVVELPLFPLPLVLFPGAILPLQIFEFRYRIMMHTLLQTDLRFGVIYADAATGTADVGCVGEVVKHERLVDDRFFLICKGQERFRVTKLLRTKPYLVAEVTWLEDRPSANGDEDLNSLANEVETYMKDVIRLSNRLNGKPEKEVQDLRRNLFPTPFSFFVGSTFEGAPREQQALLELEDTATRLKREKETLRNTLNYLTAASAMSFSYDKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG79</accession>
    <name>A0A068UG79_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00024772001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG79"/>
    <dbReference type="FunCoup" id="A0A068UG79">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG79"/>
    <dbReference type="Gramene" id="CDP07496">
        <property type="protein sequence ID" value="CDP07496"/>
        <property type="gene ID" value="GSCOC_T00024772001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG79"/>
    <dbReference type="OMA" id="YNFSIYL"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG79"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF93">
        <property type="entry name" value="ISOFLAVONE REDUCTASE HOMOLOG P3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP07496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="308" mass="33745" checksum="D57E8017F6D4F45D" modified="2014-10-01" version="1">MAEKSKILVIGGTGYIGKFIVEASIKAGHPTFVLVRESTVSDPVKGKLAQGFKNSGATLVHGDLYDHESLVKAIKQVDVVISTVGFGQLNDQGKIIDAIKEAGNVKKFYPSEFGIDVDRQNAVEPGKSVFAVKSRIRRATEAAGIPYTPLVSNAFAGYFLRTLVQPGATAPPRDKVAIWGDGNAKAVYNEEHDIGTFTIKTVDDPRTLNKVVYIMPPKNIVSFNELVAIWEKKIGKTLEKEYIPEEQVLKNIQEAPTPLNVALSIRHSILVNGDSTNFTIEPSFGVEASELYSDVKYTTVEEYLVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGY1</accession>
    <name>A0A068UGY1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025218001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGY1"/>
    <dbReference type="STRING" id="49390.A0A068UGY1"/>
    <dbReference type="Gramene" id="CDP07820">
        <property type="protein sequence ID" value="CDP07820"/>
        <property type="gene ID" value="GSCOC_T00025218001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGY1"/>
    <dbReference type="OMA" id="KKYWITG"/>
    <dbReference type="PhylomeDB" id="A0A068UGY1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF79">
        <property type="entry name" value="PROTEIN STRICTOSIDINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="244" mass="27286" checksum="69969D59D0E9B936" modified="2014-10-01" version="1">MIMVVNHRISVTHYPYAGISDGRIIKWLPDEGRWTNFAITTPHSGSRSGCEGPQDNVLTESKCGRPLGLCFNQKYGNLYIADAYMGLLVVGPSGRLAASLAKKAEGVPFKFTNDVVVDQNSGIVYFTGSSAIFPRSSLSFLLLACWTPSGRLLKFDPKTNQVTVLLKNLMFPNGVVLSKNNDFLLVAETTNCRVLKYWLEPSKAGTVEIFAKLLGRPDNIKRHQMENFGWQLFHWRTCLIHSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH29</accession>
    <name>A0A068UH29_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00024866001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH29"/>
    <dbReference type="Gramene" id="CDP07572">
        <property type="protein sequence ID" value="CDP07572"/>
        <property type="gene ID" value="GSCOC_T00024866001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH29"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="60" mass="6998" checksum="0B8321E5861640B4" modified="2014-10-01" version="1">MKDFETAGLPLPYILVKSYALLSDPTCNLPSEVISYLWKDVWWQLTITKKRIERKISAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH47</accession>
    <name>A0A068UH47_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Allene oxide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00024886001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
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        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH47"/>
    <dbReference type="STRING" id="49390.A0A068UH47"/>
    <dbReference type="Gramene" id="CDP07587">
        <property type="protein sequence ID" value="CDP07587"/>
        <property type="gene ID" value="GSCOC_T00024886001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH47"/>
    <dbReference type="OMA" id="ACEVEWL"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UH47"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CYP74"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Allene oxide synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF255">
        <property type="entry name" value="ALLENE OXIDE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP07587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="60546" checksum="D0B354184EAA3743" modified="2014-10-01" version="1">MRSSPLLAKYILHYSLHTHLPQKKLHFWLAFQGKQNMAALSSTGLLQPPSETTSPQQQEATPVSPQPKTTAPLPLREIPGSYGLPFIGPIKDRLDYFYNQGEVQFFSTRAQKYKSTVFRSNMPPGPFISSNSKVIVMLDGNSFPVLFDISKVEKKNLFTGTYMPSTKLTGGYRILSYLDPSEPKHTKLKNLLFFLLSNRKDHVIPEFHKSYTELFDSIDKEIAAKGRVTFDQDGAAFRFLGRAYYGADPADSSLGQDGPTLINKWVLFSLHPIASLGLPKFIEDPLLHTFPFPPCFVQKDYRKLYDFINANSTFVLDEAERNGIPRDEAAHNLVFATCFNTFGGIKVLFPNLMKWIGQAGVELHKKLVQEIRSAIESAGGTLTTQALENMPLTKSVVYETLRIEPPVPYQYGKAKIDLTIESHDARFEVKKGEMLFGYQPFATRDPEIFERPEEFVPDRFVGGGEELLKYVLWSNGPETESPTVNNKQCPGKDFIGFISRLFVVEIFRRYDTFEIEVVKVTALGSTIDITSLTEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI91</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="GSCOC_T00026671001"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="785928at2759"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="term" value="C:chloroplast thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="entry name" value="F24J8.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="14102" checksum="4614578721A7D32A" modified="2014-10-01" version="1">MANSLLTETAPATTAIPISTRSKQSNATQSLSFPRVSAFHRGSDQAPVPNLLYRRSLAFGLVGAVLGLNSAEKCASAAARRPPPPQPEEKKDPNVSGLTAKVLASKRRKEAMKENVAKLRKQGKPIITEPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIT8</accession>
    <name>A0A068UIT8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00026858001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIT8"/>
    <dbReference type="FunCoup" id="A0A068UIT8">
        <property type="interactions" value="1394"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP08124">
        <property type="protein sequence ID" value="CDP08124"/>
        <property type="gene ID" value="GSCOC_T00026858001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIT8"/>
    <dbReference type="OMA" id="RMTKRDP"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08295">
        <property type="entry name" value="double_bond_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="46"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="349" mass="38499" checksum="20E65DE49003771E" modified="2014-10-01" version="1">MAEVETVKNKQVLLKDYVTGFPKESDMIISTENTISLKVPENSNGVLVKNLYLSCDPFLRSLMQKPKPNSKSVFPGFKPGSPIHGYGVAKVVDSGHPKFKKGDLVWGMTGWEEYSLIQQADSLFKIEHTDVPLSYYTGILGMPGITAYGGFYEVCHPKKGEKVYVSAASGAVGQLVGQFAKLMGCYVVGSAGSKEKVDLLKNKFGFDDAFNYKEEHDLDAALKRHFPEGIDIYFENVGGKMLDAVLLNMNMFGRIAACGMISQYNLDEPEGVKNLIVVIPKKLNIRGFTASDYFSLYPKFLDLVLPHIREKKITYVEDIAEGIESVPAALIGLFSGRNVGKQIVVVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIZ7</accession>
    <name>A0A068UIZ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027472001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIZ7"/>
    <dbReference type="STRING" id="49390.A0A068UIZ7"/>
    <dbReference type="Gramene" id="CDP08530">
        <property type="protein sequence ID" value="CDP08530"/>
        <property type="gene ID" value="GSCOC_T00027472001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIZ7"/>
    <dbReference type="OMA" id="MCEILNC"/>
    <dbReference type="OrthoDB" id="1914642at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIZ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33881">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33881:SF10">
        <property type="entry name" value="SLIT HOMOLOG 2 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658011" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20943" checksum="807F38F39914B29E" modified="2014-10-01" version="1">MALSWFKISLAMVMILLPIATRGDDPLTPILNDICKEVECGKGTCQASLGYPFNFKCICDNGWRRTRLDNEETLEFLPCVIPNCSLDYSCMPAPAPLPSIPYNNSFFDPCYWIYCGGGTCIKDATYTHKCQCNSGYSNLNDIPVFPCFNQCAVGSDCSRLGVKLSSSTSSRNNDDSPGEFTNPLRSFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJW8</accession>
    <name>A0A068UJW8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00025436001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJW8"/>
    <dbReference type="FunCoup" id="A0A068UJW8">
        <property type="interactions" value="3241"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJW8"/>
    <dbReference type="Gramene" id="CDP07923">
        <property type="protein sequence ID" value="CDP07923"/>
        <property type="gene ID" value="GSCOC_T00025436001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJW8"/>
    <dbReference type="OMA" id="PAIFDCQ"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJW8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017346">
        <property type="entry name" value="UBX_7/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037991">
        <property type="entry name" value="UCP037991_UBX7/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="448" mass="50267" checksum="0B36A95AAD46A231" modified="2014-10-01" version="1">MDGVLSPADQQSLVSSFLEIAVGQTADTARQFLQATSWKLDEAIQLFYIGNEGGAAASSAQSPQLESDLPLDDPSLRSGTRTDLEDQNIRQGDGDDVRPPLPVIRDVLYDNTMLFGASRMGGSSHEARAVVPFRNFEEELKRPGVWETENGSASTVDKSQYNLASLYRPPFALMYQGSFEKAKDAARSQNKWLLVNLQSTREFSSHMLNRDTWANEAVAQTIKSNFIFWQVYDDAEEGSKVCTYYKLDSIPVVMVIDPVTGQKMRSWRGMVQPETLLEDLLPFMDGSPTDHHVNLSHKRPRESPVIRPHRVQGETEEDEDMLRALAASMEGVKDMDKKEADDVDESPQTLLTKNPAYPPLPEEPKGDKNLLCRVGVRLPDGRRLQRNFLRSDPIQLLWSFCCSQLEEAKTRPFRLTQAIPGSKSLDYNIDLTFEASGLANSMISVTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULN1</accession>
    <name>A0A068ULN1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Uncoupling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00028348001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULN1"/>
    <dbReference type="Gramene" id="CDP09139">
        <property type="protein sequence ID" value="CDP09139"/>
        <property type="gene ID" value="GSCOC_T00028348001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULN1"/>
    <dbReference type="OMA" id="YTSVPNC"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULN1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000019">
        <property type="entry name" value="Mitochondrial uncoupling protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP09139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31905" checksum="1367818553D00E33" modified="2014-10-01" version="1">MADPFEISFAGIFLSSAFAACFAELCTIPLDTAKVRLQLEKRAAISGEAGGGSSKYKGLLGTVVTIAKEEGLLALWKGIIPGLHRQCLYGGLRIGLYEPVKAFLVGGNAIEDVSLFNKVLAALVTGAIAIAVANPTDLVKVRLQAEGKMPVGVPRRYSGALDAYYTIAKQEGLAALWTGLGPNIARNAIINAAELASYDHVKESILKFPGFSDNVLTHLLAGLGAGFFAVCIGSPVDVVKSRMMGDSIYKSTLDCFFKTLKNEGPFAFYKGFLPNFGRLGLWNAIMFLTLEQVKKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMW2</accession>
    <name>A0A068UMW2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KIB1-4 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030230001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMW2"/>
    <dbReference type="FunCoup" id="A0A068UMW2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMW2"/>
    <dbReference type="Gramene" id="CDP09771">
        <property type="protein sequence ID" value="CDP09771"/>
        <property type="gene ID" value="GSCOC_T00030230001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMW2"/>
    <dbReference type="OMA" id="VQGGCHR"/>
    <dbReference type="OrthoDB" id="642536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMW2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050942">
        <property type="entry name" value="F-box_BR-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259:SF108">
        <property type="entry name" value="F-BOX PROTEIN SKIP23-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259">
        <property type="entry name" value="OS07G0183000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIB1-4 beta-propeller" evidence="1">
        <location>
            <begin position="67"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="369" mass="41202" checksum="EC82DC541813D41B" modified="2014-10-01" version="1">MGDWSQLLPDLLAVISRHLSLIEDFVAFRGVCTSWRMAAPKQNFVNLWPTVPLLMLAEKKDSDDREFYSLSRGKVWNKLSLPETKNKKCMESRGWLITVGSGGEMNMLHPLSGVQIELPHQSTFPMYDDRGTSSCFVYVRKAALSAPPSASDGFSGFVLMVIYDGGGALGFWRPGDKCWKRVEMQRPWGAFSDVNYYNGKFYAITYSGRIIVCDVSGPGSMEAQLLFSIDIELLLYRVSYLVELAGELLIVARDGAFVDEDLNYGASNFRVFQLDLINCRWKEVTSLGNSSIFVGYNAAFSVESAGFPGIIKPNCIYFTDDCIESYYDVEPGGGKDMGIYDVEDGKIERFDDIRSFSLMGPPVWVAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMW7</accession>
    <name>A0A068UMW7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029017001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMW7"/>
    <dbReference type="Gramene" id="CDP09584">
        <property type="protein sequence ID" value="CDP09584"/>
        <property type="gene ID" value="GSCOC_T00029017001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMW7"/>
    <dbReference type="OMA" id="ASMKENC"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="185" mass="21235" checksum="87D8AAB1358DE5A1" modified="2014-10-01" version="1">MKWLDDQPPSSVVFLCFGSMGSFEPDQLAEMALALEWSGYRVLWSHSNISEMLPQGFLERVQNRGLVSSWAPQMEVLAHEAVGGFVSHCGWNSILESLWHGVPVATWPVYAEQQINAFELVRELELAMDLKMDCRMENAKNLVVAEEIEKAIRCLMDTENPTRKRVLEMKEISRKAIEKFHFPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNQ9</accession>
    <name>A0A068UNQ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00030671001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Potassium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNQ9"/>
    <dbReference type="STRING" id="49390.A0A068UNQ9"/>
    <dbReference type="Gramene" id="CDP10076">
        <property type="protein sequence ID" value="CDP10076"/>
        <property type="gene ID" value="GSCOC_T00030671001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNQ9"/>
    <dbReference type="OMA" id="RNEHEPF"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNQ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF87">
        <property type="entry name" value="POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="76"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="13">
        <location>
            <begin position="571"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU321113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP10076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="773" mass="87085" checksum="F27BCF813FAE584F" modified="2014-10-01" version="1">MSTSSIAEEVATQETNTRETKITNEISSGESPPSQIQLKEQKLSCRKFSRYDSLDVEANKLHPINHHSSKVLTLHLAFQSIGVVYGDIGTSPLYVLSSTFPAGINHNDDILAVLSLILYTITLIPLIKYVFIKITNGKGGTFAMYSLICRHAKIGLIPSQEPADQDVSTFQLENHRLLRASIFKSKLEKSKFAKFFLLIITMLGTSMVIGDGILTPSISVLSAVGGIKEATSAMTEERIVWISVGILVFLFMFQRMGTDKVGYVFAPIIFVWFIFIAGIGIYNFIKYDPLVIKALNPKYILDYFRRNHKNAWISLGGVVLCTTGTEALFADVGHFSVRSIRISTCAVTYPALILAYTGQAAYLRKNNSDVSDTFFKSIPGPMYWPMFVVAIFAAIIASQAMISGTFSIIQQSLSLGCFPRVKIVHTSSKYEGQVYIPEINYLLMVACVAVTLAFKNTVKIGNAYGIAVVFVMTLTSAFLVLIMIMIWKTKILLVILYVLVIASVELVYLSSVLYKFDQGGYLPVAFAMFLMSIMFTWNYVYRKKYYFELDHKVSPEKLKEVIIDTNSYRLPGLAIFYSELVHGIPPIFKHYVENVPALPSVLVFVSIKSLPISKVPMEERFLFRRVRPNDLNVFRCVVRYGYTDVRNEQEPFEKLLVERLGEFIKEDYKFSIVEESQGNHEEMDSDGSGNGENVDHDQEAVKRDIEVLEEAWRAGIVHFVGEQEVVAGKGASLGKRILIDYAFNFLKRNLRQSNEVFDIPQKRMLKVGMTYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URK2</accession>
    <name>A0A068URK2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00031915001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URK2"/>
    <dbReference type="STRING" id="49390.A0A068URK2"/>
    <dbReference type="Gramene" id="CDP10942">
        <property type="protein sequence ID" value="CDP10942"/>
        <property type="gene ID" value="GSCOC_T00031915001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URK2"/>
    <dbReference type="OMA" id="CAPTWDF"/>
    <dbReference type="OrthoDB" id="1916120at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35278:SF1">
        <property type="entry name" value="F8K7.16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35278">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP10942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="237" mass="27362" checksum="C9FA12924FEBA2BF" modified="2014-10-01" version="1">MGNVVGSVLGGVSEVLGKLLGHPLDFLSGKSCSSKCGPTWDLTCYIENFCIAQLLKLGLVVVLLYFVLVFFYLSYKLGICQCICHIICRSIWACCATWFSVLEFCCTFLCSKLDKHNRRRRRRRRDIEAPATTSEDDLNDDEDDHGGRFTNQATKHISKRRRLLSGQKRHYREEHMRRALRPNSHRVHVGVSEESFRSKRRNSSKYHDHVNPVDHIRVTRTSKFAQKRGSFKGSMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URV5</accession>
    <name>A0A068URV5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00031054001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URV5"/>
    <dbReference type="STRING" id="49390.A0A068URV5"/>
    <dbReference type="Gramene" id="CDP10348">
        <property type="protein sequence ID" value="CDP10348"/>
        <property type="gene ID" value="GSCOC_T00031054001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URV5"/>
    <dbReference type="OMA" id="MAMEPET"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URV5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="40857" checksum="F56532F474F13F42" modified="2014-10-01" version="1">MDTDDKKMVINDLENFVRRKELYRKVGKAWKRGYLLFGPPGTGKSSLIAAIANYLKFDIYDLELTDIRTNSDLRRYLISTANQSILVVEDIDCSIELTNNRPKASRAPVHPHQYGQENRICQSILAVSSIWSMPFILLVGPITAFHQAKKFPVTLSGLLNFIDGLWSSCGDERIIVFTTNHKDKLDPALLRPGRMDVHIYMSYCTPCGFKLLASNYLGITDHPLFLVVEQLMKVTKVTPAEVGEQLLKNGEPETALEGLIQFLEEKKKNVEFENHKSNQQAPEAAVPLELEEEGGNEGETNVISLEAIKDLVKMNKVSSDEVQVIKKDEADIILRGLIQLLLEKKETQVLKIDSGSSAEKLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTU5</accession>
    <name>A0A068UTU5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035320001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTU5"/>
    <dbReference type="STRING" id="49390.A0A068UTU5"/>
    <dbReference type="Gramene" id="CDP11980">
        <property type="protein sequence ID" value="CDP11980"/>
        <property type="gene ID" value="GSCOC_T00035320001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTU5"/>
    <dbReference type="OMA" id="NLLEWHK"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF14">
        <property type="entry name" value="INACTIVE PROTEIN KINASE SELMODRAFT_444075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="320"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="609" mass="68963" checksum="14E1705099EF7FB6" modified="2014-10-01" version="1">MESIKDHPLMPARVVVAYDATKDRTEIEFSHTIHSIRSRGDILHGGDTLMFLGVLSKVPHPSKHLDISSMLGITHVRLVEEEVSNKVDFCVRLLQKSAEEYDSEGVDIEVKITAGTPTRKVVLQEVITSNATWVILDRHLRRDLRFYLKQIPCKVAIIEDNLSMVVVRPSTISDTDKVEPNLFISLAKNVPLLAAPNEENNEQFIMSCKSYSPSMGSLENSDRIKSNLLPALKYNPQDHNISSHHEFGPNSEDKSGRHAKGGSKPPISPQVIEKLRRKPSGQRSNDTPVLCIGCGMKTKPDIKDSMKFSFSEIQLATDDFSKDNLLGEGGYGHVYKGRLKDGQFIAAKLRKEASTQGFAEFLSEIYVLSFARHKNIVMLLGYCCKENLNILVYEYICNKSLEWHLFDNEGDVLEWHRRHSIAIGTAKGLRFLHEECRGSPIVHCDMRPSNILLTHDFVPMLGDFGLAKRRTDEGNMHKRILGTLGYLAPEYAENGIVSVKTDVYSFGIILIQLMSGRKVVDSNRLDQQHSLRQWAIPLIQRLALHELVDPRIQDFYDTYELYLMVRAAYLCVQTNPEMRPTMGEVLRLLEGESDHLNQLADQFVPHFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUS8</accession>
    <name>A0A068UUS8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KIB1-4 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035380001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUS8"/>
    <dbReference type="FunCoup" id="A0A068UUS8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUS8"/>
    <dbReference type="Gramene" id="CDP12024">
        <property type="protein sequence ID" value="CDP12024"/>
        <property type="gene ID" value="GSCOC_T00035380001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUS8"/>
    <dbReference type="OMA" id="VIYQCEL"/>
    <dbReference type="OrthoDB" id="642536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUS8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050942">
        <property type="entry name" value="F-box_BR-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259:SF108">
        <property type="entry name" value="F-BOX PROTEIN SKIP23-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259">
        <property type="entry name" value="OS07G0183000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIB1-4 beta-propeller" evidence="1">
        <location>
            <begin position="73"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="380" mass="42785" checksum="60880116605B35CC" modified="2014-10-01" version="1">MGDWSKLQHDLLELIAQQHLTKLEDYVAFGAVCTSWRAAAAKRKNFKGLQLWQQIPCLMLAESEEENDNHREFYSLIEKEIVAKISLPKLKGKKCYESLGWLLAVGQEGDMTLLNPFSDVEIPLPPGTTFPDNDWLNTDPEIFVEIFVLSARPSETSDFVVMLVCGSVGYLAFWRQGDQNWTKIETHNAAYSAVNYHNGQFYAIDCTGTLVACDVSGPNPTKARMLTQLVLDFKHLYIVLESSSSDKESLLVVTRDNYSHYADDDDQPNYGTTEFKLYEVDLSGGTWKEIHSLGNKAVFVGHSASTSLEVSSNKFSLPGIQPNHIYFTDDCWEAYKSIQEVTGGKDMGVYNLETGTIQPFYQGPRRLSNISPSIWITPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUY6</accession>
    <name>A0A068UUY6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00035501001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUY6"/>
    <dbReference type="FunCoup" id="A0A068UUY6">
        <property type="interactions" value="2078"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUY6"/>
    <dbReference type="Gramene" id="CDP12112">
        <property type="protein sequence ID" value="CDP12112"/>
        <property type="gene ID" value="GSCOC_T00035501001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUY6"/>
    <dbReference type="OMA" id="TIVCYQI"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUY6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="203"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="760" mass="82799" checksum="D4560C989D9C1360" modified="2014-10-01" version="1">MAWRVAGRKGIRACLAEALTISFRDPVFPNTKVDLEAAQTTFFSSVKQKQSYSVNPGLRIFDDLNFFSSRCLIRLFHASPQLLVRRDDDTPWGLKTQLKGKFKNRPKSSSSPVEAPYVPPKIKRVSRSLPDKTIEIFEGMTILELAKRCGESIPTMQSILVNVGEKVDSEFDPLGIDIAELVAMEVGVNVRRLHSDEGTNVLPRSPVVTVMGHVDHGKTSLLDALRQTSVAAKEAGGITQHLGAFVVGMQSGGSITFLDTPGHAAFSAMRARGAAITDIVVLVVAADDGVMPQTLEAMSHAKAAGVPMVVAINKCDKPTANPERVRLQLAAEGLLLEEMGGDVQVVEVSAINKIGLDKLEEALLLQAELMDLKARNDGPAQAYVVEARLDRGRGPLATAIVKAGTLVSGQFVVVGAEWGRIRAIRDTAGKMTNFARPAMPIEIEGLKGLPMAGDDIIVVHSEERARMLSEGRKKKRERDRLRKLEEEKREKEKEEIEGGEEEEEELKATELGDERGRGKRRRKERRKLQEKENKPKRPELPIVVKADVQGTVEAVVDALKGLNSPQLPVFVVHVGVGPISQSDIDMAEACGACIVGFNVRNPPSSISLAATQAGVKIKLHRVIYHLLEDIGNLIVEKAPGTFETQVAGEAQVLNIFELKGRSKAKGADVKIAGCRVTDGRFTKLSTMRILRSGEVVFEGSCTSLKREKHDVDAVGKGNECGLVIQDCIDFRVGDVIQCLEQVNIKPKFISSENGAVRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV92</accession>
    <name>A0A068UV92_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Terpene synthase metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035806001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV92"/>
    <dbReference type="STRING" id="49390.A0A068UV92"/>
    <dbReference type="Gramene" id="CDP12331">
        <property type="protein sequence ID" value="CDP12331"/>
        <property type="gene ID" value="GSCOC_T00035806001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV92"/>
    <dbReference type="OrthoDB" id="1877784at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV92"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="165" mass="19042" checksum="2C2C7241406CAF1E" modified="2014-10-01" version="1">MDVAERYFCFEWLRAISGSWEYILSLNMHSPERLCQRRNVGCMKLLDLFEEIEEEMAKKGRSYLEHITPRKHCWLMPILLRLSGCTKGTYIPTMKECMATCGYTTLKITSFLGMGDIVTKESFDWASNDPDILRAASIICRLWDDIVGHKVQTNFLSKTQGKSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVC1</accession>
    <name>A0A068UVC1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00035657001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVC1"/>
    <dbReference type="FunCoup" id="A0A068UVC1">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVC1"/>
    <dbReference type="Gramene" id="CDP12232">
        <property type="protein sequence ID" value="CDP12232"/>
        <property type="gene ID" value="GSCOC_T00035657001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVC1"/>
    <dbReference type="OMA" id="HESISHQ"/>
    <dbReference type="OrthoDB" id="1911459at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVC1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34970">
        <property type="entry name" value="ABC TRANSPORTER A FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34970:SF2">
        <property type="entry name" value="ABC TRANSPORTER A FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="72" mass="7755" checksum="14DDD05619181A1F" modified="2014-10-01" version="1">MGYVLRVRTASFFAGAAVASAMGIYALQQDYKNAHRTHSQQAIGVYQSLEGRISALEKSQEVQPAKSVQAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVR3</accession>
    <name>A0A068UVR3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00036324001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVR3"/>
    <dbReference type="FunCoup" id="A0A068UVR3">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVR3"/>
    <dbReference type="Gramene" id="CDP12630">
        <property type="protein sequence ID" value="CDP12630"/>
        <property type="gene ID" value="GSCOC_T00036324001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVR3"/>
    <dbReference type="OMA" id="HLSETCI"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVR3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF53">
        <property type="entry name" value="UDP-ARABINOSE 4-EPIMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="8">
        <location>
            <begin position="74"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="415" mass="45972" checksum="9CA6B9AE3903DD6E" modified="2014-10-01" version="1">MLSLNRTRTQSRSTRSMSLGGMDYVDPKKKSNVVGKVFMAAALTALCIIMLKRSPTFNTPSPFAHYEPGVTHVLVTGGAGYIGSHAAFRLLKDSYRVTIVDNLSRGNLGAIKVLQELFPEPGRLQFIYADLGDAKAVHRIFSENAFDAVMHFAAVAYVGESTMDPLKYYHNITSNTLGVLEAMHTHGVKTLIYSSTCATYGEPEKMPITEQTPQKPINPYGKAKKMAEDIILDFHKNSDMAVMILRYFNVIGSDPEGRLGEAPRPELREHGRISGACFDAARGIIPGLKVRGTDYKTEDGTCIRDYIDVTDLVDAHVKALEKAKPGKVGIYNVGTGRGRSVKEFVEACKKATGVPLKVDYLPRRPGDYAEVYSDPTKIRTELNWTAKYTNLQESLRVAWRWQKAHINGYSTPQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWN3</accession>
    <name>A0A068UWN3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00037488001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWN3"/>
    <dbReference type="STRING" id="49390.A0A068UWN3"/>
    <dbReference type="Gramene" id="CDP12826">
        <property type="protein sequence ID" value="CDP12826"/>
        <property type="gene ID" value="GSCOC_T00037488001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWN3"/>
    <dbReference type="OMA" id="ICGSHEN"/>
    <dbReference type="PhylomeDB" id="A0A068UWN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20618">
        <property type="entry name" value="CYP71_clan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF4">
        <property type="entry name" value="OS09G0441700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44702" checksum="446975494A72FA47" modified="2014-10-01" version="1">MESFSPTWAAYALVWVATVVIAHLSKHFHQKKLNLPPGPRQWPIIGNLNLIGTLPHRSLHQLSLTYGPLMHLQFGSFPNSIVTPEEFRQMLDEVFLLTGVFNIGDFIPWIDFLDLQGYIKRMKILSKKFDRFLEHILDEHNAQRKDETDCVSKDMVDVLLGLADDPTLEVKLERHGVKALILDLLAGGTETSATTVEWAISELLKNPEILNKAAEELDRVIGQNRWVNEKDMPNLPYIEAIVKETMRMHPVVPLLVPRCAREDCKVAGYDIQKGTRVIVNVWSIVRDPESWEKPEVFWPDRFMGKDIDFKGQDCKFLPFGAGRRMCPGYSLGLKVIQSSLANLLHGYRWKLPNDMKPEDLDMEEIFGLTTPRKIPLVAIVEPRLPCNLYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXG7</accession>
    <name>A0A068UXG7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Two-component response regulator-like APRR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00037671001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
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        <text evidence="7">Binds the target DNA as a monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="EnsemblPlants"/>
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    </evidence>
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            <dbReference type="EMBL" id="CDP12959.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="553" mass="61389" checksum="E028E818BBE1D1E3" modified="2014-10-01" version="1">MVCTADELLGWKDFPKGLKVLLIESDACSAVEMRLKLEEMDYIVSIFCNENEALSAISNKSECFHVAIVEVNTQNSSGIFKFLETANDLPTIMISDNNCISTMMKCIALGAVEFLQKPVSDDKLQNIWQHVVHKAFNAGGKDVSEALKPVKESLISMLQLPFGNAETGKQASVEAEQENNQDLLSGCDKYPAPSTPQLKQGERSLDDGDCQDQANFSMEQDSAEQDGECKSVETTCGNSIFECTALGSPASGEDAVKEEHESTNCCRTEINTTTCYEGKDRPSNKTSNAAGLNRSSAVRNTCGIKASKKRSKVDWTPELHKKFVQAVEQLGIDQAIPSRILELMKVEGLTRHNVASHLQKYRMHRRHILPKENERRWPHPGGSAQRNYYPHKPVMAFPPYHPNHTIPGGQVYPAWIPPGTYTGGIHIWGSPYYPGWQVPNESWYWKPYSMTHADAWGCPVMPQTVGSYPQFAQTAPDFQTTIEMQYTGSTLLNPSDLHAAEEVIDQVVKEAISKPWLPLPLGLKPPSTECVLNELSRQGISKIPPHTKAPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXQ3</accession>
    <name>A0A068UXQ3_COFCA</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
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        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="9">
        <location>
            <begin position="491"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="772" mass="87761" checksum="1E7AC7CCD7AE8230" modified="2014-10-01" version="1">MADAAISATIQVALETVISLAADRVSLVLGFGEELERLRHTAETIRGILADADRKMHIAGVKNWLEQLEGELFKAEDVLDELNYENLRREVKDRNQLKKKVCFFFSHFNTIGSRSRLASKIRDINLNLERINRQANDVGLVFRFQIEAALPAATGATTSRQTDSILVPNVVGRVDDESKIVDMLSSPSEKVLSVIPITGSGGLLVNKEKEEWKSIVKESQTDEDQDEIDQILKVSFDHLSPASVKKCFAYCSIFPQDTELREDELIQHWMAEGFVQPDRQNQRLMEEIGGEYLRILLQSSLLEKVEEPRTYYKLHDLVHDFAKSVLNPKSSSQDRYLALHSYEEMAENGRRNKPASIRSLFLHLEGGISADMNMLSRFKHLHVLKLSGYNAKFLPISIGKLLRLRLLDISSSGITSLPESLCKLYNLQTLTIDDDELEGGFPKRMSDLISLQHLNYDDYHVELKIPVQMGLLTCLQTLEFFNVSQERGRGIEELGTLKYLKGSLEIRNLELVKGKEAANQAKLFEKPDLFSLMFKWESGYRESDNRDEDVLEGLHPHPNLERLEIRYFMGNKFPQWLINLSKLEALHIIGCKRCSELPSLGQLPSLKRLELVRLDNIRFIGDEFYGEAEADVFPMLRNFHIRNCPQLTTLPCSCKSLHVLWIYSCDNLRELPDLDLFGSSLQQLTIARCPRLISLGVNGQKCPLLLGLKELSIDDCEGLTTISDKMFQSCRSLRSLSVERCPNLVSFSLNLQETPSLERFILFESDLSSSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXV1</accession>
    <name>A0A068UXV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase</fullName>
            <ecNumber evidence="1">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038079001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="1"/>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXV1"/>
    <dbReference type="STRING" id="49390.A0A068UXV1"/>
    <dbReference type="Gramene" id="CDP13211">
        <property type="protein sequence ID" value="CDP13211"/>
        <property type="gene ID" value="GSCOC_T00038079001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXV1"/>
    <dbReference type="OMA" id="TVANYEC"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXV1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF18">
        <property type="entry name" value="AMINE OXIDASE [COPPER-CONTAINING] ZETA, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="282" mass="31558" checksum="5A94FCC6A370F286" modified="2014-10-01" version="1">MLPLLLKNLSYHLLLQDGKIEAEVKLTGILSLGALQPGEVRKYGTTIAPGLYAPVHQHFFVARMDMAVDCKPGGTHNQVVEVNVIVEEPGDDNVHSNAFYAEEKLLKTELEAMCDCNPSTARHWIVRNTRAVNRTGQLTGYKLVPGSNCQRLARPEAKFLRRAAFLKHNLWVTPYSHDEKFPGGEFPNQNPRVGEGLATWVRENRPLEETDIVLWYVFGVTHVPRLEDWPVMPVEHIGFTLMPHGFFNCSPAIDVPLSSCDSDVKENGMITKPCHNGLVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY26</accession>
    <name>A0A068UY26_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein BIG GRAIN 1-like A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00038402001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in auxin transport. Regulator of the auxin signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BIG GRAIN 1 (BG1) plant protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY26"/>
    <dbReference type="STRING" id="49390.A0A068UY26"/>
    <dbReference type="Gramene" id="CDP13450">
        <property type="protein sequence ID" value="CDP13450"/>
        <property type="gene ID" value="GSCOC_T00038402001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY26"/>
    <dbReference type="OMA" id="RELHMFD"/>
    <dbReference type="OrthoDB" id="680041at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY26"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039621">
        <property type="entry name" value="BG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33541:SF12">
        <property type="entry name" value="PROTEIN BIG GRAIN 1-LIKE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33541">
        <property type="entry name" value="PROTEIN BIG GRAIN 1-LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47217" checksum="B505A2717B61928D" modified="2014-10-01" version="1">MYSWEKSLREEKSRNNPKNPSFSSSLLDEIYRSIDGYDEKGEEWKLNKERSHATSIKKHNGGRAKSSSIVEDEEMASLKRACLIEKWMEKKVHEKVSSQRKELDNDPLFFSSGSSSSDSSSGGLSSSDTEFFASIKTRKSCFASSRPKPVRTSVSPRRGQQKNEFLMFSRDQESVETEENLIKSKSRALKIYANLKKVKQPISPGGRLTSFINNLFTNGHSKKSKACCEDANAEKKSKKSSSISQVSSSVSTCSSASSFSRSCLSRSSPNSRAKLNNGAKRTVRFCPVSVIVDEDCRPCGHKSTYDQDSDRFGKPPLMSQNSTAQRKTEGAAAAAERDRDNLKAYHQNHKKENFAIDRMIQDHHEEDYDDDDEDAASDSSSDLFEIDHLALFGNNRFCEELPVYETTHLDTNRAIASGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ92</accession>
    <name>A0A068UZ92_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rx N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00037681001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ92"/>
    <dbReference type="STRING" id="49390.A0A068UZ92"/>
    <dbReference type="Gramene" id="CDP12968">
        <property type="protein sequence ID" value="CDP12968"/>
        <property type="gene ID" value="GSCOC_T00037681001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ92"/>
    <dbReference type="OMA" id="DEFMILE"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ92"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338:SF32">
        <property type="entry name" value="OS06G0287500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26779" checksum="8671951D0E23C15D" modified="2014-10-01" version="1">MAETVLSFVLDQLSTFLREEGRLLGGLRQEVQFIRDELGHMRAFLREAEAKEEDAQPRLQEWIKQVREAAYDTEDILDEFVARFARHLPTGFYRSVRRIFSCIKNLRARHRVASEIRSIKSRIKSISEGHQRYQSGYGISAQPSNSLSAVNNTTWRYSRDDALLVEEAKLVGIDQPKKHLISQLLEGDDHQLKVVSVVGTGGLGKTTLVKRVHEDPEVRRHFPVGEKSKCQARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0A3</accession>
    <name>A0A068V0A3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00038194001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0A3"/>
    <dbReference type="STRING" id="49390.A0A068V0A3"/>
    <dbReference type="Gramene" id="CDP13303">
        <property type="protein sequence ID" value="CDP13303"/>
        <property type="gene ID" value="GSCOC_T00038194001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0A3"/>
    <dbReference type="OMA" id="SQMGWGA"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0A3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000033">
        <property type="entry name" value="Lysine histidine transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="25"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="439" mass="49164" checksum="EEF9F78BE6CF4A24" modified="2014-10-01" version="1">MDNQLPLKTAEEKAIEDWLPVSSVRKSKWWYSAFHNVTAMVGAGVLGLPYALSQLGWGPGVTMLAISWMITLFTLWQMVEMHEMVPGKRFDRYHELGQHAFGEKLGLWIVVPQQLLVQVSTCIVYMVTGGKSLKKFHDIVCPPPRCQDIRLTYFILIFASVHFVISHLPNFHSLAIISFSAAVMSLSYSTVAWMTSLFKGQIPNVSYVPRGSTAAGKTFNFLNALGDVAFAYAGHNVVLEIQATIPSTPDKPSKRPMWKGVVLAYFVVALCYFPVAICGYYAYGNEVEDNVLITLQKPSWLIAAANMFVVIHVIGSYQVYAMPVFDSLESVLVKSLRFKPSNKLRFITRMLYVAVTMLTGMAIPFFGGLMGFFGGFALAPTSFYLPCIIWLILYKPKRFSFSWIINWILIVFGVLLMLLSPIGGLRSIILSAKSYKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V112</accession>
    <name>A0A068V112_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00040687001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V112"/>
    <dbReference type="STRING" id="49390.A0A068V112"/>
    <dbReference type="Gramene" id="CDP14351">
        <property type="protein sequence ID" value="CDP14351"/>
        <property type="gene ID" value="GSCOC_T00040687001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V112"/>
    <dbReference type="OMA" id="SARIMHH"/>
    <dbReference type="OrthoDB" id="1938097at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V112"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="119" mass="13136" checksum="8375772B4E565B4B" modified="2014-10-01" version="1">MDRLDDASNLLLEIAELSTPFGSSVERVAAYFADALSARIMHHCLYDITGSDFATLRLLTLLRPKLITIVEQGLSHEGSFLGRFVEALHYYSMLFDALGDGLATDSGEKHMVEQQLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1K7</accession>
    <name>A0A068V1K7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00041053001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1K7"/>
    <dbReference type="STRING" id="49390.A0A068V1K7"/>
    <dbReference type="Gramene" id="CDP14536">
        <property type="protein sequence ID" value="CDP14536"/>
        <property type="gene ID" value="GSCOC_T00041053001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1K7"/>
    <dbReference type="OMA" id="IMTARIG"/>
    <dbReference type="OrthoDB" id="1929062at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1K7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP14536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="180" mass="20019" checksum="7DB2A909A6FE728D" modified="2014-10-01" version="1">MLRSLITRAAGGAAVTSLYFFPFLTCVEAFRPNDDALLRLIAQSCPNLRHLSFHGSYNATEGAILEVMSKCPKLELIDFSDSPYFTPTVLEHMSTCCPEVRGIRRNGFLQPGFASALAVGFPNLRILNLSGSTIVDKDLLTIMTARIGIQYLDITNCQQLKCYMHIIKRAPVQISQILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V230</accession>
    <name>A0A068V230_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Subtilisin-like protease SBT5.6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00041098001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V230"/>
    <dbReference type="FunCoup" id="A0A068V230">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V230"/>
    <dbReference type="Gramene" id="CDP14569">
        <property type="protein sequence ID" value="CDP14569"/>
        <property type="gene ID" value="GSCOC_T00041098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V230"/>
    <dbReference type="OMA" id="VCWPVPD"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V230"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000002">
        <property type="entry name" value="Subtilisin-like protease SBT5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655487" description="Subtilisin-like protease SBT5.6" evidence="9">
        <location>
            <begin position="22"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="140"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="12">
        <location>
            <begin position="666"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="82600" checksum="12574C783C1915AB" modified="2014-10-01" version="1">MEKYLAVLCFLFISLHMKAVCEKRQVYIVYLGEHSGNRNLEEIEEHHRSFLHSVKGSKQEAETCLIHSYKHIINGFSAFLTPEEASTVSEMDGVISVFRSQTRRLRLQTTRSWDFTNLLEANGDLSRVNGEKLLQRASYGKDVIVGVFDSGIWPESRSFNDEGMEPVPKSWKGTCQQGIAFNSSHCNRKIIGARYYLKHYEAEHGPVKEKMEFRSPRDKNGHGTHTASTIGGRRVPNASSLGGFANGTASGGAPLVRLAIYKICWQPDPLDEVLCPDGDTLAAFDDAIKDGVHVISLSIGGNTSSPYAEDGTAIGSLHALKRDIIVVCSAGNSGPTPSSVSNVAPWLISVGASSIDRIFQSTIVLGNGLIVQGRTVTPFRKTKKYPLVYAVDVEIPGKTTNLTTGGCFPGTLSKKLVKGKVVFCWVGYIYQALEVRRAGGVAAIFGNPYGGKGVVESPFLLPGTTVLQNDRATIVSYILNNENPTATLFPGRTIIGTGPAPFMAPFTALGPNGIEPNILKPDITAPGLNILAAWTEASPPTQLLQDHRVVKYNIASGTSMSCPHVSAVAALLKAIHPDWSSAAIRSSLMTTARRVNNVQIPITDAAGNIATPFHYGAGHFQPSKAADPGLVYDASYTDYLLFLCSSGTAFLDPSFKCPKHVPPPSDLNYPSLAIAKLNGNMTVSRTVTNVGTGNSTYTVIIVPPPGYTVKILPTKLYFSKTGEKQSFSITVKVAASIKETKFEFGWYAWSDGAGHVVRSPIVVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2L7</accession>
    <name>A0A068V2L7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042586001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2L7"/>
    <dbReference type="STRING" id="49390.A0A068V2L7"/>
    <dbReference type="Gramene" id="CDP15045">
        <property type="protein sequence ID" value="CDP15045"/>
        <property type="gene ID" value="GSCOC_T00042586001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2L7"/>
    <dbReference type="OMA" id="CESSENF"/>
    <dbReference type="OrthoDB" id="2014869at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2L7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13569" checksum="BD66283831771279" modified="2014-10-01" version="1">MGDHPKESLCVTSLHKSILQKALLFFNGFVAKLTKEEKKRLTSVVSMFPNGKKQLHTTRSWDFVGIPQDASRKTLESDIIIGMLDSGIWPESESFNDSGYGLPPSRWKGTCESSENFTCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4F8</accession>
    <name>A0A068V4F8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00042150001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4F8"/>
    <dbReference type="Gramene" id="CDP14723">
        <property type="protein sequence ID" value="CDP14723"/>
        <property type="gene ID" value="GSCOC_T00042150001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4F8"/>
    <dbReference type="OMA" id="RCIVELP"/>
    <dbReference type="OrthoDB" id="1896560at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4F8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658234" description="Disease resistance protein RGA3" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="171"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="435"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="684"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="961"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP14723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118349" checksum="D78856E54C719A3D" modified="2014-10-01" version="1">MAEAALSCVSVILNKILPLAAAEINRAWGVEKDLQKLADNVRTMEALIFDAECKQSTSKAAQLWLKWLQSTARDAEIVLDDFGYEVLRQKVKNRKRDKVLNLLYSSNPFFFRLGMADKIKKVMASLEEAYKKANQIGLHPAQLPMASADHKVDQQRWTAPFVDESETVGREAEVSKVVSMLISSDCKKDLPVISIVGMGGQGKTTLAQLVLKNESVTKHFDKIIWVCVSDDFRVERLLNHMLQSLGDHSLGEKNAETTTKEALVRRLQENLKGKSYLLVLDDIWNDDPLKWNDMRICLLAIGGAPGSKILATTRSDEVASAMQTSALHHLDILSDDHSWMLFEKLAFADGGAKTQDLVDIGTRILKKCGGVPLAIKVIGGLLYSKKDASEWSKLEKSEIWNESTDIAKRVMSVLKLSYENLPSWSVKQCFASCSIFPKDALMEKESLIQIWMTQGLINDAKGGGHLQMEDIGSEYLNILLRSSLLQAGYKNSIYGIWSCRMHDLVHDLSLQVSNNCFLNTEGGMEVRHENEVMRLTIIGSQGKVLKKIEGIPPNLQTLYYRGGDGIMLEDILERSRYLCVLIVDCWDMTHLPNAVGDMKHLRHLDIHETKITALPDSITKLYNLMTLKVYYLEEIPKKFSNLINLRHFEVSLDGSRCLFPGIGQLANLRTLPHFRVSQEKGCQLEELEHLRNLRGKLKIFGLENVSSFESAAKAKLSEKSSIQGLRLSWDDTNEDCDDNNINSVMEGLQPHPDLKSLAIWGFKGSRFPSWMVAKDGLMVLLRNLVRLRLEKLGKCEQVPPLGDLPCLESLWMVSLPNVKRIGAEFYGLDINARSSAFTLFSKLKCFELRDMGSLEEWSDAMVPSDSSSSIKVFPNLRDLRIAGLPKLAVLPDMENLTSLAELSIRECGSLACIRNLNSLTSLEFLYLNDCSALLDASLDMKNPQSLRELIISGCDKLNPSLNQIQHLSTLTSLEIGEFEGLEVLPEWMGSLRNLQELWIVDCSNLRQLPSAEATRHLTNLNQLVINSCPVLAERCTKGSGVEWPKIAHIPYVFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5V7</accession>
    <name>A0A068V5V7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016821001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5V7"/>
    <dbReference type="FunCoup" id="A0A068V5V7">
        <property type="interactions" value="895"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5V7"/>
    <dbReference type="Gramene" id="CDP15909">
        <property type="protein sequence ID" value="CDP15909"/>
        <property type="gene ID" value="GSCOC_T00016821001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5V7"/>
    <dbReference type="OMA" id="MCCDGDC"/>
    <dbReference type="PhylomeDB" id="A0A068V5V7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055283">
        <property type="entry name" value="TAXIMIN_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33834:SF2">
        <property type="entry name" value="SIGNALING PEPTIDE TAXIMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33834">
        <property type="entry name" value="SIGNALING PEPTIDE TAXIMIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="8379" checksum="6F8C9EDC14C4A83D" modified="2014-10-01" version="1">MCCGDGDCRPLAFLLSLPFAFLALLVSLVGVIIWIVGILLSIICPCCLCVTVLVEMALQLIKAPIHVMEWFTSQIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V650</accession>
    <name>A0A068V650_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00017049001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739199">
        <property type="protein sequence ID" value="CDP16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V650"/>
    <dbReference type="STRING" id="49390.A0A068V650"/>
    <dbReference type="Gramene" id="CDP16047">
        <property type="protein sequence ID" value="CDP16047"/>
        <property type="gene ID" value="GSCOC_T00017049001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V650"/>
    <dbReference type="OMA" id="RPTATMF"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V650"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000722">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF585">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="170"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="451" mass="50126" checksum="216714EF1F9A2920" modified="2014-10-01" version="1">MVNLQNLLLAYNRLEGSIPVSIGTTLSLEWLDLSHNHLTGTIPMSLENLRSLVYFNASYNKLRGEIPSKGPFSNFTGESFISNEGLCGAPRFHVPLCPGISGGRLRTKKLRRTISVVFGAFISVAVATFLVFVYLRCSKKEQAPSEGVLPSAATQERIPYYKLLQATDGYDESNLLGTGSFGSVYKGTLDDGRIVAVKVFKLQQEGAFNSFDAECEVLRCLRHRNLTKVISSCSNEDFKALVLEFMPNGSLEKWLYSHNYFLEIKQRLDILIDVACALQYLHYGLSTPVVHCDVKPSNVLLDQDMVAHVTDFGVAKLLGHEDSFTYTKTLATLGSLAPEYGLEGLVSTKCDVYSFGIMIMEVFTRKSPNDEIFGENLTLKSWVSDSMPDGLVRIVDGNLLRPNDESFDEKLDCISSIMKVAVNCTKESPRERSNMHVVLADLKKIKTQLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V801</accession>
    <name>A0A068V801_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00019241001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V801"/>
    <dbReference type="FunCoup" id="A0A068V801">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V801"/>
    <dbReference type="Gramene" id="CDP16756">
        <property type="protein sequence ID" value="CDP16756"/>
        <property type="gene ID" value="GSCOC_T00019241001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V801"/>
    <dbReference type="OMA" id="MMELYIH"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V801"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17991">
        <property type="entry name" value="DEXHc_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="entry name" value="Transcription-repair-coupling factor, D7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF29">
        <property type="entry name" value="TRANSCRIPTION-REPAIR-COUPLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="TRCF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="102"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="285"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="72962" checksum="C407F69E9726E7CC" modified="2014-10-01" version="1">MAKLPVKQASRMLYRYNLPNETKKPRALSKLSDPSAWERRRVKGKVAVQKMVVDLMELYIHRLKQRRPPYPKMHAIAEFASHFPYKPTPDQMQAIIDVEKDLTEKENPMDRLICGDVGFGKTEVALRAIFCVVSAGKQAMVLAPTIVLAKQHYDVISDRFSRYPDIKVGLLSRFQSKSEKEEYLHMIKHGHLDITVGTHSLLGNRVVYNNLGLLVVDEEQRFGVKQKEKIASFKTSVDVLTLSATPIPRTLYLALTGFRDASLISTPPPERVPIRTHLSSYSKVKVVSAIKYELDRDGQVFYVLPRIKGLEEVMEFLEESFPEVEIAIAHGKQYLKELEDTMARFALGEIKILICTNIVESGLDIQNANTIIIQDVQQFGLAQLYQLRGRVGRADKEAHAHLFYADKSLLSDQALERLTALEEYRDLGQGFQLAERDMAIRGFGNIFGEQQTGDVGNVGIDLFFEMLFESLSKVDEHRVISVPYQSVQLDLNINPYLPSEYINYLDNPMEVISEAEKAARQDIWSLMQFTESLRWQYGKEPYSMEILLKKLYVKRMAADLGITRIYSSGKIVGLKSNMSRKVFKLIIDSVASDIHCNSLVFENGLIKAELPLELPREQLLNWIFQCLAELYACLPALIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8R4</accession>
    <name>A0A068V8R4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00019456001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739223">
        <property type="protein sequence ID" value="CDP16879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8R4"/>
    <dbReference type="FunCoup" id="A0A068V8R4">
        <property type="interactions" value="1817"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8R4"/>
    <dbReference type="Gramene" id="CDP16879">
        <property type="protein sequence ID" value="CDP16879"/>
        <property type="gene ID" value="GSCOC_T00019456001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8R4"/>
    <dbReference type="OMA" id="MPECDVH"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8R4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000195">
        <property type="entry name" value="AAA-type ATPase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="605" mass="66267" checksum="CE783215F026B634" modified="2014-10-01" version="1">MEQLVSMGFPNSLAAEALKAAGGDIVKATDWILSRSQTTPSPPHRHTADTATALQPPQIHHDNSPSPPPPLSPAAASSNFQPKIDRFFHFRCKTQTPTPATSSSSKSQLCKEEVQQQQHDHADEDVLDDDDHHLQGGKRPRLSSSPQERDNYASKQQPSSSPVAFPREPLSELMRPSTLDQVVGQEHLLGPNSALRSAIRHSRLPSIVLWGPPGTGKTSIARAIVSSCSDVYRFVPFSAVNSGVKEVRDAVEEARKWKSKNSKIDNNRRMRTVLFIDEVHRFNKAQQDSLLPVIEDGSIVFIGATTENPSFHLITPLLSRCTVLVLNPLKPHHIATLLKRAISDSDKGLSSFSKVQVEDEAIEFLAAHCDGDARVALNKLELSATTAATERFHQKKGRGGGEGSLDSDVLSITVSHVKEAMQSKHIAYDRDGEEHYNLISALHKSMRGSDADASIYWLARMLEGGEQPLYIARRLIRFASEDVGLADPSALTQAVACYQACHFIGMPECNVVLAQCVAYLALAPKSISVYRAIQDAQKVARDSVGQNEGVPLHLRNAPTKLMKEIGYGKGYVYPPDNPKASSQTYMPPSLQGYKFLHWPNAPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9M3</accession>
    <name>A0A068V9M3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF538 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00009710001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739239">
        <property type="protein sequence ID" value="CDP17361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9M3"/>
    <dbReference type="FunCoup" id="A0A068V9M3">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9M3"/>
    <dbReference type="Gramene" id="CDP17361">
        <property type="protein sequence ID" value="CDP17361"/>
        <property type="gene ID" value="GSCOC_T00009710001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9M3"/>
    <dbReference type="OMA" id="WMSFLQI"/>
    <dbReference type="OrthoDB" id="755906at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9M3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.240.10">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036758">
        <property type="entry name" value="At5g01610-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007493">
        <property type="entry name" value="DUF538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676:SF71">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676">
        <property type="entry name" value="T31J12.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04398">
        <property type="entry name" value="DUF538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655704" description="DUF538 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20262" checksum="A33C7E2C7D23514B" modified="2014-10-01" version="1">MGLIPKSELCNLPLTLLLILLFSSVIFSVSGEASEPTAYEILQKYGLPIGLLPDSVTSYSLSEDGAFEVHLEKPCYVQFDYLIYYEKKITGQLSIGAITELKGVQVRRFLFWFDVDEIKVDLPPSDNIYFTVGFINKKLDVDQFETVHSCRDETALCGQSLRNVFQLPTPVDDVPLLITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9P6</accession>
    <name>A0A068V9P6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00007929001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739248">
        <property type="protein sequence ID" value="CDP17495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9P6"/>
    <dbReference type="FunCoup" id="A0A068V9P6">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V9P6"/>
    <dbReference type="Gramene" id="CDP17495">
        <property type="protein sequence ID" value="CDP17495"/>
        <property type="gene ID" value="GSCOC_T00007929001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9P6"/>
    <dbReference type="OMA" id="KNYICAT"/>
    <dbReference type="OrthoDB" id="726732at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V9P6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000023">
        <property type="entry name" value="heparanase-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363:SF21">
        <property type="entry name" value="HEPARANASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363">
        <property type="entry name" value="HEPARANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655707" evidence="11">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP17495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="547" mass="61047" checksum="7FC5F4AD7DCE58F4" modified="2014-10-01" version="1">MGWRTSGVIFLVFLPSILAQNIGSAVLLIDSTAKFAETDTNYICATIDWWPKEKCNYNQCPWGSSSLLNLDLSHPFLSNAIQAFKNLRLRLGGSLQDQVHYDVGNISCTPFVKQKDGLFGFSKGCLHMKRWDELNSFFKKTGALVTFGVNALYGRHKNRRGVWQGEWDSSNAHDFIKYTISKGYHIDSWEFGNELSGKGVGASVDAEQYGKDVANLNSIIIEEYKSFHPRPFVLAPGGFFDKDWYSRLLLVSGPQVVDVLTHHIYNLGAGVDHNLINKILNPHYLSKIEATFGNLSRIIQTDGPWASAWVGEAGGAFNNGGRHVSDTFVNSFWYLDQLGLAAKFDTKVYCRQTLIGGNYALLDTTTYVPNPDYYRQGQLLFQKPTTYALLWHQLMGSGVLSIDSNEPYLRSYAHCSKQKKGVTLLLINLSNETAFSVDVESVTHTDLPVEEKSKKKSFLHNLKKTVSWVGSKAADEDLFREEYHLTPKDGDIQSKTMLLNGKPLKLTDGGGIPTLAPEFVDLNSPVFIDPLSIKFIVLPNFGAPGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAK7</accession>
    <name>A0A068VAK7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00003140001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739263">
        <property type="protein sequence ID" value="CDP17746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAK7"/>
    <dbReference type="STRING" id="49390.A0A068VAK7"/>
    <dbReference type="Gramene" id="CDP17746">
        <property type="protein sequence ID" value="CDP17746"/>
        <property type="gene ID" value="GSCOC_T00003140001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAK7"/>
    <dbReference type="OMA" id="FLASCDE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VAK7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF148">
        <property type="entry name" value="CYTOCHROME P450 72A15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="100" mass="11594" checksum="F1F78097E325A6D3" modified="2014-10-01" version="1">MGQERRLITPAFHHKKLPGMVPEFLASCCNLIDRWKMLVASDGWSEIDINPKLQSLSTDVISRAAFGSSYKEGKKIFELQKDHQIKTCERHTNYTEDQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBB4</accession>
    <name>A0A068VBB4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00004790001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HG739225">
        <property type="protein sequence ID" value="CDP16968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBB4"/>
    <dbReference type="FunCoup" id="A0A068VBB4">
        <property type="interactions" value="3557"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBB4"/>
    <dbReference type="Gramene" id="CDP16968">
        <property type="protein sequence ID" value="CDP16968"/>
        <property type="gene ID" value="GSCOC_T00004790001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBB4"/>
    <dbReference type="OMA" id="FKTIWTL"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="176"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="371"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP16968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="590" mass="66203" checksum="6BE6C1A86A4A589B" modified="2014-10-01" version="1">MMAEEDDDYVEYIPVAKRRALEAQKILQRKGKSSTLEAEEAEKLKLVEAKPSLLVKASQLKKEQPEISPTEQMVQQEKEMIEHLSDRKTLMSVRELAKGITYTEPLFTGWKPPLNIRRLSKKVCDAIRKQWHIIVDGEDIPPPIKNFKDLRFPDPILKKLKAKGIVQPTPIQVQGLPVILAGRDMIGIAFTGSGKTLVFVLPLIMVALQEEIMMPIAPGEGPFGLIVCPSRELARQTYEVVEQFLVPMREYGYPELRPLLCIGGVDMKSQLEVVKKGVHIVVATPGRLKDMLAKKKMNLDSCRYLTLDEADRLVDLGFEDDIREVFDHFKAQRQTLLFSATMPTKIQKFARSALVKPVVVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQKTPPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEEREYAIKSFKEGKKDVLVATDVASKGLDFPDIQHVINYDMPAEIENYVHRIGRTGRCGKTGIATTFINKNQSETTLLDLKHLLQEAKQRIPPVLAELNDPMEDVDAITNASGVKGCAYCGGLGHRIRDCPKLEHQRSTQIASSRRDYYGSGGYRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBC4</accession>
    <name>A0A068VBC4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dof zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00004809001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739225">
        <property type="protein sequence ID" value="CDP16978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBC4"/>
    <dbReference type="STRING" id="49390.A0A068VBC4"/>
    <dbReference type="Gramene" id="CDP16978">
        <property type="protein sequence ID" value="CDP16978"/>
        <property type="gene ID" value="GSCOC_T00004809001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBC4"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992:SF313">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF5.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP16978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="95" mass="10624" checksum="9FE4308B6641F2C1" modified="2014-10-01" version="1">MQFAKHKGFYSLAQPRHFCKTCRRYWTKGGALRNVLIGGGCRKNKKSKPPSRLTVDPKDTNMTSDIGGLKFFHGLTPAMDFQLGGITSYLLPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBZ6</accession>
    <name>A0A068VBZ6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00011802001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739303">
        <property type="protein sequence ID" value="CDP18241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBZ6"/>
    <dbReference type="STRING" id="49390.A0A068VBZ6"/>
    <dbReference type="Gramene" id="CDP18241">
        <property type="protein sequence ID" value="CDP18241"/>
        <property type="gene ID" value="GSCOC_T00011802001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBZ6"/>
    <dbReference type="OMA" id="FLFTQYR"/>
    <dbReference type="OrthoDB" id="5210at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001960">
        <property type="entry name" value="PRK00733.3-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP18241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="780" mass="82068" checksum="3B9641DFE2F60918" modified="2014-10-01" version="1">MGLMSEAFSQTLIPVCALIGILFALVQWFLVSRIRVASSGPDSYEDQLIEEDDEQVEGIDSAEVVNKKCAEIQNAISVGATSFLFTEYKYLGIFMFVFGVIIFIFLGSVKGFSTKSEPCTYNEGNLCKPALANAIFSTIAFWLGSLTSVLSGFLGMKIATFANARTTLEARKGIGKAFITAFRSGAVMGFLLAANGLLVLYVSINLFKLYYEDDWEGLYESITGYGLGGSSMALFGRVGGGIYTKAADVGADLVGKVEKNIPEDDPRNPAVIADNVGDNVGDIAGMGSDLFGSYAESSCAALFVASISSFGIHHDYAAMSYPLIISSVGIIVCLITTVIATDVVEIKTVSEIEPSLKRQLLISTVLMTVGIAGVSFLVLPSKFTLFDFGADKVVKNWHLFFCVSIGLWAGLVIGYVTEYYTSNAYSPVQDVADSCRTGAATNVIFGLALGYKSVIIPIFAIAIAIYVSFSLAAMYGIAMSALGMLSTIATGLAIDAYGPISDNAGGIAEMAGMSHRIRERTDALDAAGNTTAAIGKATSHLWLSNPGSSSEGVLLGFAIGSAALVSLALFGAYVSRAGIKTVDVLTPKVFIGLIVGAMLPYWFSAMTMKSVGSAALKMVEEVRRQFDTMPGLIEGTRKPDYATCVKISTDASLKEMIPPGALVMLTPLIAGTLFGVETLAGLLAGSLVSGVQVAISASNTGGAWDNAKKYIEAGASEHARTLGPKGSDAHKAAVIGDTVGDPLKDTSGPSLNILIKLMAVESLVFAPFFASHGGLLFKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCI9</accession>
    <name>A0A068VCI9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00004222001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of either four A chains (GAPDH 2) or two A and two B chains (GAPDH 1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HG739339">
        <property type="protein sequence ID" value="CDP18560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCI9"/>
    <dbReference type="FunCoup" id="A0A068VCI9">
        <property type="interactions" value="1216"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCI9"/>
    <dbReference type="Gramene" id="CDP18560">
        <property type="protein sequence ID" value="CDP18560"/>
        <property type="gene ID" value="GSCOC_T00004222001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCI9"/>
    <dbReference type="OMA" id="DAYSHDD"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCI9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP18560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="386" mass="41031" checksum="1D050F599EC3FE2E" modified="2014-10-01" version="1">MASAALSVANSSLQVSNKGFSEFAGLRSSSLPFARKASDDLLSVVAFQTSVIGGGKNKRGVVEAKLKVAINGFGRIGRNFLRCWHGRKDSPLDVVVINDTGGVKQASHLLKYDSTLGIFEADVKPADEGISVDGKVIKVVTNRNPVNLPWGEMGIDLVIEGTGVFVDREGAGKHIQAGAKKVLITAPGKGDIPTYVIGVNAETYNPDETIISNASCTTNCLAPFVKVLDQKFGIIKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVALVLPKLKGKLNGIALRVPTPNVSVVDLVVQVEKKTFAEEVNAAFREAADKELNGILSVCDEPLVSVDFRCTDVSSTVDASLTMVMGDDMVKRVVDLADIVANNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCN9</accession>
    <name>A0A068VCN9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00000922001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739244">
        <property type="protein sequence ID" value="CDP17448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCN9"/>
    <dbReference type="Gramene" id="CDP17448">
        <property type="protein sequence ID" value="CDP17448"/>
        <property type="gene ID" value="GSCOC_T00000922001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCN9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="226" mass="26190" checksum="1427DE96E13DDF44" modified="2014-10-01" version="1">MKLVPAKKSKDSVGRFPIKRIKKIVLRRYSKTNLIQVQKLIKHYASTKVHLCLTKSMNSGIAFWFSNIILVINNTREHIILKKGRREYCKEKESWVDYPIEKGERIGPGEHACCCASKFGKDWRRTQKLMRKYSEMRVSLEGEDDRKAKVLSLPEVMNNIAFVFNMGDNSQLVMETVSREEAKSRKIEPSLWKKLEEMKVQCISVVNKRKTACKEGAREELGTAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDM5</accession>
    <name>A0A068VDM5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">65-kDa microtubule-associated protein 3-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00003896001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MAP65/ASE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDM5"/>
    <dbReference type="STRING" id="49390.A0A068VDM5"/>
    <dbReference type="Gramene" id="CDP17778">
        <property type="protein sequence ID" value="CDP17778"/>
        <property type="gene ID" value="GSCOC_T00003896001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDM5"/>
    <dbReference type="OMA" id="LHFQENA"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDM5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1520:FF:000002">
        <property type="entry name" value="65-kDa microtubule-associated protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF22">
        <property type="entry name" value="65-KDA MICROTUBULE-ASSOCIATED PROTEIN 3-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="550"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="79871" checksum="AE4E78DD10ADFCF4" modified="2014-10-01" version="1">METTCGSLLSELQKIWDEVGEPETERDKMIFELEQECLQAYRRKVDQASQCRAQLQQAVADSDSELAFIYAALGERPMHVRQTSGSLKVELQAVTSELEQMRKRKMERKNHFIEVVEQIDNISKELSVSSEETLSMTIVDDSDLSLKRLEDLKTQLLALEKEKSNRLKQVLDHLNTLNSLCLVLGLDFKLTVSEIHPTLDDSSSVRSISVQTIERLSIAIRRLKDLKIQRVQKLQDLAATMVELWCLMDTPVEEQQRFQNVTCNIAASVNEITQPNTLSLDFLEYAEAEVLRLQQMKSSKIKEVLFKKRLQLEEICRGAHMVVEDHNPIDFSIETIESGAIDPSYLLEQIEVQISKIKEEAFSRKEILEKVEKWLVACEEERWLEEYNRDDNRYNAGRGAHLILKRAEKARGLVNKIPAMIEVLTSKPKAWEKQRGVEFLYDGVSLLSMLDQYRILKEEKEQERQRQRDQKKLQGQLMVEKEALFGSKPSPTKSSRKIFGTSAGGGSSNKRFSVGGMMLQNSYPEKAVHTSQFSNKSNTSKLHVLQNFQPHGGTILSSGKRHISGVQSKKPSSYGSDQRQTELRSIRKPLSPLYSSFSSNANYANLQDEKNRNQELVDTLPSNKADMVTPNKRIPAFEGNETPKCMPIPMPLTPSTVSSTMRMAMTPATPCVPPGNGGIEYSFEERRAGFILPKSQCDIQGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VER7</accession>
    <name>A0A068VER7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DH200=94 genomic scaffold, scaffold_371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00009232001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DH200</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DH200</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739455">
        <property type="protein sequence ID" value="CDP19186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VER7"/>
    <dbReference type="FunCoup" id="A0A068VER7">
        <property type="interactions" value="3134"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VER7"/>
    <dbReference type="Gramene" id="CDP19186">
        <property type="protein sequence ID" value="CDP19186"/>
        <property type="gene ID" value="GSCOC_T00009232001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VER7"/>
    <dbReference type="OMA" id="CPHPCDS"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VER7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd16492">
        <property type="entry name" value="RING-CH-C4HC3_NFX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056234">
        <property type="entry name" value="RRM_NFXL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24435">
        <property type="entry name" value="RRM_NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP19186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121570" checksum="C12C89E6BCA37041" modified="2014-10-01" version="1">MSFPVQRNRRDNRSRNRTTSPVQGARREWVLRGPAPIATTAAPTPTTAAIPPTNYSPAVAADDVIRNGNNGDQNGRSVPPANMTRNTSGARCIMRQHSNQRRERDKEKQRDHSREVKESKDLNLPLLVQEIQDKLMKGSVECMICYDMVRRSAPIWSCSSCYSIFHLACIKKWARAPTSVDLSAEKGQGCNWRCPGCQAVQLMSSKEIRYVCFCGKRQDPPPDLYLTPHSCGEPCGKALEKEVPGSGMAKEDLCPHLCVLQCHPGPCPPCKAFAPARWCPCGKQVITTRCSDRKSVLTCGQRCDKLLDCGRHRCERTCHVGPCDPCDVLVNASCFCKKKIEVVLCGDMVVKGEIRADDGVFSCSSICEKKLGCRNHFCDDICHPGPCGECDLLPSKIKTCCCGKMRLKEDRESCLDPISTCSQTCGKSLPCGVHHCKEMCHTGVCAPCPVLVTQKCRCGSTSRTVECYRTTAENENFTCDRPCGQKKNCGRHRCSERCCPLSNPNKSFSGDWDPHLCSMPCGKKLRCRQHSCHSFCHSGHCPPCLDTIFTDLTCTCGRTSIPPPLPCGTPPPSCQYPCSVPQPCGHPSTHSCHLGDCPPCTIPIAKECIGGHVVLRNIPCGSKDIRCNKLCGKTRQCGLHACARTCHPSPCDTPSGTSIGSRASCGQPCGAPRRDCRHTCTALCHPTGSCPDVRCEFPVSITCSCGRINATVPCDAGGSGGGYSSDTVLEASIVQKLPAPLQPVEGNVKVPLGQRKLMCDDECAKTERKKVLADAFGVTTPNLDALHFGENAVVSEVLSDLLRREPKWVLSVEERCKYLVLGRGRGGINAVKVHVFCPMSKEKRDIVRLIAERWKLSVNAAGWEPKRFIVLHVTPKSKAPARILGLKGCLASNMLQPPVFDPLVDMDPRLVVALFDLPRDADISALVLRFGGECELVWLNDKNALAVFSDPARAATAMRRLDQGSLYYGAVVVPHHGGASATAVAAAAAANAWGATGPSKDGGAVTALKTNPWKKAVMQEPDGRESSWGAEDWSDNSVDVHSSIRKGNEVPISATNRWSVLDSENSSSTSSGRNDDSRNKPGTPLVSSVKPSSSSSVLPGQPQGAGINEISDVVDDWEKAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VET6</accession>
    <name>A0A068VET6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00009658001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">cv. DH200-94</strain>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Thymidine_kinase"/>
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    </dbReference>
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        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="76" mass="8337" checksum="13BFE4C0342841B7" modified="2014-10-01" version="1">MLDEGFRPNHVTYLAVLAACSCGGLDTRYALDSIVTNDGEKLPCWPLANLSSFRQKLGSEGYDKLEVIGIDEAQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG12</accession>
    <name>A0A068VG12_COFCA</name>
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        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_540</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00001820001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDP19542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="CDP19542">
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        <property type="gene ID" value="GSCOC_T00001820001"/>
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    <dbReference type="OMA" id="KHERHEF"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DUF7650"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057712">
        <property type="entry name" value="DUF7952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF11">
        <property type="entry name" value="GRUNGE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7650"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DUF7952" evidence="7">
        <location>
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            <end position="266"/>
        </location>
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            <end position="392"/>
        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="805" mass="89482" checksum="B109B98CACA6EB28" modified="2014-10-01" version="1">MMIDASLPSGDSIGCDLFREQEIFPRVGANYQVEVPILVQKSEYLSLVKNVANTENGPVELNWGLPIPVFMVSQDRAKENAKVSQSLEVFSTDDSNAVLDNGVPVGESCGAVLEDRRDQCIFPGCSIVPGCANGSWIDLEKKCFLLGLYIFEKNFVQLRRFIESKNMGDILSFYYGEFYRSHDYCRWSECRKMRGRRGVFGQKIFTGLRQQELLSRLFPRVSGKCKNALLEVSKTFVEGKMSLEEYVFSLKAMVGLSLLVEVVGIGKGKQDLTGMALEPVRSNHAIPMRPEIPTGKACSSLTSNEIVKFLTGDYRLSKARSSDLFWEAVWPRLLARGWHSEEPKDPGYAAGSKNSLVFLVPGIKKFSRRRLVKGNHYFDSVSDVLSKVASEPGLIELENEVDESKRKEEEYECSRKRKLEGDDMPNQRRRSYLQPRTPYRGSDGMKFTIVDTGLEDARKVKELRRLLREFSSEFNSGNSYDIIDDDSSEVSTEESDSPDMTLHNKGDNDTSNASNHLSNGEILPDRKDLQIHAPTCENHASYDMNPAFKRARGLTACNHLETSNVLTDRAILPKSDSELSSRGSDVRDFAENVPPLVATPPDKLSLSNSSKGSPTESVEHDTVSCLVASDPQQSSQNPTLIDLNIPQVPVDFETGSLRTDATTENPVDHDELERAPDKVNPEHQANMNLQRRGTRVRPPTTRALEALAHGYLTVNRRRKGSEARSRENMRSRPSRRARGAGQGVAFQSVHQLNLGSVDPRSEPGSNSVDSTVQGGENVGKLQVQHAGNVTPIPGNVSVEGTSRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGC7</accession>
    <name>A0A068VGC7_COFCA</name>
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        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00012517001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502:SF2">
        <property type="entry name" value="16 KDA PHLOEM PROTEIN 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502">
        <property type="entry name" value="C2 DOMAIN-CONTAINING"/>
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    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP19756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="149" mass="16352" checksum="556E8277951500FF" modified="2014-10-01" version="1">MQRGTLEVLLVSAKGLENTDLLSNMDPYAIITCRTQEKKSSVASGQGSEPEWNETFLFTISEGVTELKIKLMDSDNLTNDDFVGESTIPLGAVLAEGSVPIASYNVVKDDKYCGEIRIGLNFKREAGSDEGYYGQEESFGGWSQSSRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGH4</accession>
    <name>A0A068VGH4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00004579001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDP18778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CDP18778"/>
        <property type="gene ID" value="GSCOC_T00004579001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGH4"/>
    <dbReference type="OMA" id="TYLQRRW"/>
    <dbReference type="PhylomeDB" id="A0A068VGH4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_17"/>
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        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="9">
        <location>
            <begin position="266"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP18778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="388" mass="41441" checksum="20AFF5D531439A00" modified="2014-10-01" version="1">MGIWAVNHGVLVKIFVLCMMVSSVICIGANWGTQSTHPLPPSTIVKLLRDNGIQKVKLFDADPSILYALGGSGIEVTVGIPNDMLYSLANSVAAAELWVQRNVSAHISSTSVDIRYVAVGNEPFLTTLNGTYTGTTYPALQNVQAALIKAGLGTRVKNNGIGNLSIIVGEVGWPTDGDLHANIQYAQRFNQGFMSHMGKGTPMRPGTVDAYLFSLIDEDAKSIKPGNFERHWGVFNYDGTPKYNLSLGSNSVGLVAASNVQYLSRQWCVMSSNASLDDPQVAPSVSYACSHADCTSLGYGTSCGNLDTGGNISYAFNSYYQENNQLLSACQFPGLSVVTTTDPSQGVCVYKVMIRTSTLGGGANVSSGFLSEPSNLLLLLFMIFLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGK7</accession>
    <name>A0A068VGK7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00010059001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739374">
        <property type="protein sequence ID" value="CDP18823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGK7"/>
    <dbReference type="FunCoup" id="A0A068VGK7">
        <property type="interactions" value="1959"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGK7"/>
    <dbReference type="Gramene" id="CDP18823">
        <property type="protein sequence ID" value="CDP18823"/>
        <property type="gene ID" value="GSCOC_T00010059001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGK7"/>
    <dbReference type="OMA" id="AMYKSMI"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGK7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000018">
        <property type="entry name" value="Gamma-tubulin complex component 6 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="64"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="906"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP18823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1235" mass="139402" checksum="51A9BAACA8E95CB7" modified="2014-10-01" version="1">MAVEANMVAALLEKLKVDDPWVQPQPWESIPSESGRRQNPSTSRSQSSHGLYPISNLSESSLVRLVLTALQGLESALIAVDQLSALFCSVSADRTFHRISSLWSWSSSTRSLGNLLKSIGQFGCIVFLLHKFVAYFSLLNADGDSGLQTTPKEVNGENKAQSEFKGSVVNQAFAVAVKKILDGYISALNTVHTSVSLRRNLKNSTGGCLTSVGDTEVTVLEVYLHTKGLRTQIEALGNICQICDTAYSFSLSSFEDLSAKANLEFANFPRGGTLLTFLYTQLKVVDPAQIVLLKFLFLQAFEPYYHFIRSWIYGGRMSDPYKEFAMEYVDYLPGYGRGYAGISIEFPLSTVRVRDGVTLPCFLEDFLIPLLRAGQQLQVVMKLLDLCYSLGTYNNAQEEILPFLDEFSNEYPFFASPLTFDKETMGRMALARSSYYQRMLEKVDNVLTRFGFRSQKESPYTIQFFFSKNHGRNPKHAEATLDDNLVPAVMEEDAGIFQNEASSTADELSCAEDLLESSESSSLKSFDEHNDSEQMPNDNMGFQPSYLSSVSFSFGLSAENSVWKPFKSEISCFSENFSKVGEKTQEACHGMDSYYEGSNMNRNSSTLQFAEQNLLLSAESKIINVEPDVCLRAGCMADSLSYLNGGNNSGTWFDMTGSALEVRKSMLGECKASMLNCSNTTLPRIAITEMTKNRHQHGDGNCASSNSLCVQPWTSKYNTSLLSMNPTLMKGYFINNSDMLEERGLKYKDPLSYFDFTSVRDPCQVCQEKLASTSGRECGFGNSIPTETTADAAIITSDYYCKDRINKDNEERMKRSLVYLSSHSVMDRGKDALCADLTGGSDWETILACFGTNTNVTEKGYRTSSLAAFDMPLDYVIEKCLWEEILLQYKYVSRLTLKLLEEGFDLQEHLLALRRYHFMELADWADLFIMSLWHHKWHVIEVDKRILEIQGILELSVQRSSCEGDFNKDRLYVYIKGDCVMPLSASAKGIRSFDFLGLGYRVDWPVSIILTPDALKIYSNIFNFLIQVKLAVFSLSDAWCSLKDIVKLTRRSKPSDRLKPTLQHISALTETRYQVFHFITTLQQYVQSKLSHVSWRKFSDSLKHKVKDIMDLEAVHMEYLTESLHICFLSDELRSIAKIIQSILQCAVDFQSCLSRCTLEVGPSGKDPELPQIDIVQVLNIKKTFAKNINDLFLCYRKSPKHGEFGLSRFWDYLNYNDYYTEGRGRQLEHGALYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGY3</accession>
    <name>A0A068VGY3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C6-oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00009212001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>6-deoxocastasterone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxycastasterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69875"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:20712"/>
            <dbReference type="ChEBI" id="CHEBI:20760"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:69876"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>6alpha-hydroxycastasterone + reduced [NADPH--hemoprotein reductase] + O2 = castasterone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69879"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:20760"/>
            <dbReference type="ChEBI" id="CHEBI:23051"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:69880"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739895">
        <property type="protein sequence ID" value="CDP19976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGY3"/>
    <dbReference type="FunCoup" id="A0A068VGY3">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGY3"/>
    <dbReference type="Gramene" id="CDP19976">
        <property type="protein sequence ID" value="CDP19976"/>
        <property type="gene ID" value="GSCOC_T00009212001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGY3"/>
    <dbReference type="OMA" id="NQVKYNN"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000045">
        <property type="entry name" value="Cytochrome P450 85A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF169">
        <property type="entry name" value="CYTOCHROME P450 85A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP19976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="464" mass="53027" checksum="6DA840CB8265FA65" modified="2014-10-01" version="1">MAVLMVVLGVVFGLCILSTALLKWNEVKYRKKGLPPGTMGWPVFGETTEFLKQGPGFMKNQRSRYGSFFKSHILGCPTIVSMDPELNRYILVNEAKGLVPGYPQSMIDILGKSNIAAVHGSAHKHMRGALLSLISPTVIREHLLPTIDEFMRSHLSNWGDSVIDIQQKTKEMAFLSSLKQIAGIESGTIAQEFMPEFFMLVLGTLSLPINLPRTNYHRGLQARKNIVSLLRKLIEGRRASGKTSCDMLGFLMNDEVNKYKLTDEQMIDLIITILYSGYETVSTTSMMAVKYLHDHPKVVEEVRKEHMAIRERKRPEDPIDFDDYKSMRFTRAVIYETSRLATIVNGVLRKTTEDMQLNGFIIPKGWRIYVYTREINYDPCLYPDPLKFNPWRWLDKNLENKNYFLIFGGGTRQCPGKELGIAEISAFLHYFVTTYRWEEVGGDELMKFPRVEAPNGLHLKISTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHU3</accession>
    <name>A0A068VHU3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00007989001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740040">
        <property type="protein sequence ID" value="CDP20167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHU3"/>
    <dbReference type="Gramene" id="CDP20167">
        <property type="protein sequence ID" value="CDP20167"/>
        <property type="gene ID" value="GSCOC_T00007989001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHU3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="109" mass="12935" checksum="CF4C20BEA0BB06B4" modified="2014-10-01" version="1">MSVSLPQKALLPLFLFLLVITNGAIFPLLSFIFPIDNNETKIWYEIWRFSLSFSCYFMLQLRNLQITSIILMLFSELFHPFLKVQKLEFSLILSKTTNKVVRKNKLEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI78</accession>
    <name>A0A068VI78_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-amylase</fullName>
            <ecNumber evidence="4">3.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00011842001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 14 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="HG740411">
        <property type="protein sequence ID" value="CDP20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI78"/>
    <dbReference type="STRING" id="49390.A0A068VI78"/>
    <dbReference type="Gramene" id="CDP20530">
        <property type="protein sequence ID" value="CDP20530"/>
        <property type="gene ID" value="GSCOC_T00011842001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI78"/>
    <dbReference type="OMA" id="FNFTCAE"/>
    <dbReference type="PhylomeDB" id="A0A068VI78"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016161">
        <property type="term" value="F:beta-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001554">
        <property type="entry name" value="Glyco_hydro_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001371">
        <property type="entry name" value="Glyco_hydro_14B_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31352">
        <property type="entry name" value="BETA-AMYLASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31352:SF40">
        <property type="entry name" value="BETA-AMYLASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01373">
        <property type="entry name" value="Glyco_hydro_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00842">
        <property type="entry name" value="GLHYDLASE14B"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="149" mass="17122" checksum="5AA865120396C394" modified="2014-10-01" version="1">MWCRHYACLNFTCLEMRDSEHPKAKSGPQELVRQVLSAGWRENIDVAGENALSRYDRVGYNQILLNSRPNCVNKNTLPKLKLSGLTYLRLSDKLLGRKNFSIFKTFVKRMHADQDYDPDHIDLPAQKASKQKISFGQLLDATKPIEPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJJ7</accession>
    <name>A0A068VJJ7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00009894001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741021">
        <property type="protein sequence ID" value="CDP20886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJJ7"/>
    <dbReference type="STRING" id="49390.A0A068VJJ7"/>
    <dbReference type="Gramene" id="CDP20886">
        <property type="protein sequence ID" value="CDP20886"/>
        <property type="gene ID" value="GSCOC_T00009894001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJJ7"/>
    <dbReference type="PhylomeDB" id="A0A068VJJ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="93" mass="10463" checksum="968101FBBC5ACC8F" modified="2014-10-01" version="1">MVGGGSDGSLDLYEATGIRPEFLRDAMSLKQVQRKTLTPMKFFGRDTAKYPPLMKTRNLSKSLKYLTKAYLGNHDVQMGPQDPYEGCVATMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK90</accession>
    <name>A0A068VK90_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_2343</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00003846001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741427">
        <property type="protein sequence ID" value="CDP21037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK90"/>
    <dbReference type="Gramene" id="CDP21037">
        <property type="protein sequence ID" value="CDP21037"/>
        <property type="gene ID" value="GSCOC_T00003846001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK90"/>
    <dbReference type="OMA" id="LSWINAF"/>
    <dbReference type="PhylomeDB" id="A0A068VK90"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="183"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP21037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="433" mass="48851" checksum="0452346E8F278E6B" modified="2014-10-01" version="1">MADPVISATIQVALETAVSLATDRIGMLVGFKKDVASMTRTLSWINAFLADAEERQQNQDRLVQEWLKSLEEVAYEADNVLDELHYESLRQQVESRNRHKLKVCCFFSFSNINLAFRWRMASKVRDVKLKLKEINQQARDFGLDSKSVVPAALPAAVGDTRNRQTDSVLVPITGRADDESNIVKILLSPSKKVVSVLPIIGMGGLGKTTLAKSIYNNHQIDGHFQKKIWVCVSEKVPRVELFKLILGQLKKDKKDEVGDRQNIVQEVGKELGKLRYFLVLDDVWDDNQTLWDDFFNTLTGLNPVNPPKGSWCLITTRLHLVADKGYPLGRLPGDHCWSIIKGKVVEGEEVPNELDAIKDRAIQICNGLPLVASVLGGLLRLRKDKWRSILEDRLLNLNEAMQILQLSFDNLPSPAIKKCFAYCSIFPQDTEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKA1</accession>
    <name>A0A068VKA1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2579</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00009181001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741663">
        <property type="protein sequence ID" value="CDP21131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKA1"/>
    <dbReference type="FunCoup" id="A0A068VKA1">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VKA1"/>
    <dbReference type="Gramene" id="CDP21131">
        <property type="protein sequence ID" value="CDP21131"/>
        <property type="gene ID" value="GSCOC_T00009181001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKA1"/>
    <dbReference type="OMA" id="DETTCRN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKA1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001079">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g17210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000227">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g13880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF452">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="770" mass="85290" checksum="54C5F58BCE352DF0" modified="2014-10-01" version="1">MAVRLPSISSVSRLPSCFSKIKNLAATGRWQEVLSCHRELREAGVQLTDPSVFPPILKACSAISFDYGKSIHASLLKQGLDSFTSLGNSIIDFYVKSGTLGCANDVFDCMRNRDSVSWNIIIHGHLDQCAFEQGLGLFFQAKITGFKPNISTLVLVICACRERQLFDDGQILHGYIIRSGFLAISSVQNSLLCMYADIRMEFARKLFNEMHHRDVISWSVIIGWYVQNSEARVALELFRQMVSEFHIEVDGPITVTILKACTNLQNIEMGNLVHGFAISRGLKCDLFVGNSLVDFYSKCDDVESAFKAFSEMSQKNVVSWNSLLSGYVQSEKHSEALLLFDSMRRAGVEADEVTLVNLLQVCKYLMLPYQCKLIHSKVLRQGYESNELVKNSLIDTYAKCNCISLAWKQFSQMKHRDAVTWSTMIAAFTYWDMPGEAIALFREMKLIEENLNTVTMLNLIEACSLFADLNISKSAHGIAIRHGLAFEVAVGTAVLDMYSKCGAIQASRKAFEYMPQKNIVSWGAMIAAYGMNGLPRDALALHAKMESQGLKPNLVTSLSLLSACSHGGLVDEGLSVFENVIQEYGVEIGVEHYSCLVDLLARSGKFDSAMDFINKIPCTVKPSASAWSAILSGCRNSGNREVGAGALAHILELEPSSSVGYLLASNMYASGGLWSDAANMRLLGKRSGAKVLAGYSLVHVNNRAYRFVAGDKHDPLSDELCIFIEQLHSWMKIENTDHDNILGTKRKEVKSCSSSFRLQQQLEQFVDAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL50</accession>
    <name>A0A068VL50_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH200=94 genomic scaffold, scaffold_4076</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00003289001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG743160">
        <property type="protein sequence ID" value="CDP21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL50"/>
    <dbReference type="FunCoup" id="A0A068VL50">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VL50"/>
    <dbReference type="Gramene" id="CDP21431">
        <property type="protein sequence ID" value="CDP21431"/>
        <property type="gene ID" value="GSCOC_T00003289001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL50"/>
    <dbReference type="OMA" id="YYWENMI"/>
    <dbReference type="OrthoDB" id="623055at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VL50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051358">
        <property type="entry name" value="TF_AMS/ICE1/BHLH6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="153" mass="17799" checksum="164EFF8F43C641EC" modified="2014-10-01" version="1">MDDMDVVYKYYWENMILQTEQLGRNFDESFSFYDSSSPDGAQSSAASKNIESERKRRQKLTETLHALRAVVPNISKMDKASIIKDAICYIQQFHNQERMIQAEISELESKRSIFLDFDQEISYNSKPKRSRFEQTCDSAKSRSSPIEVFEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMD9</accession>
    <name>A0A068VMD9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_6593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00006531001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG745677">
        <property type="protein sequence ID" value="CDP21777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMD9"/>
    <dbReference type="STRING" id="49390.A0A068VMD9"/>
    <dbReference type="Gramene" id="CDP21777">
        <property type="protein sequence ID" value="CDP21777"/>
        <property type="gene ID" value="GSCOC_T00006531001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMD9"/>
    <dbReference type="OMA" id="ASICNEG"/>
    <dbReference type="OrthoDB" id="3027644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMD9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338:SF66">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="171"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP21777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="276" mass="32375" checksum="06156D252303CD78" modified="2014-10-01" version="1">MADPVISFVIERTGDLLIQKIVFLEGVRRQVERLQKDLVRMRCFLKDADQRQDKDARIRNWVSEIRAAAYDAEDIIEIFASKVEFFTKDKGLVTKLMYYPLKIVNLYKIGKEIESLRLRLKEIADSREEYGIKNLGEEMTTHGEELQRIRRSSPFSEDKDIVGFDEITKSLVAELLKQDKNRRVVSIVSMGGAGKTTLAKKVYNHAHVRERFNCCAWVCVSSSYDHKKMLRAIIKQLNEMSNEQLEKMEEEELERRLYQDLQDKCYLVVLDDVWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMZ9</accession>
    <name>A0A068VMZ9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_9761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00011746001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748845">
        <property type="protein sequence ID" value="CDP22066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMZ9"/>
    <dbReference type="STRING" id="49390.A0A068VMZ9"/>
    <dbReference type="Gramene" id="CDP22066">
        <property type="protein sequence ID" value="CDP22066"/>
        <property type="gene ID" value="GSCOC_T00011746001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMZ9"/>
    <dbReference type="OrthoDB" id="909822at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMZ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF15">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP22066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="353" mass="40037" checksum="3BE868CF4195B2E9" modified="2014-10-01" version="1">MRNNKQIEPQVFDVDELFQFTMKKNWKEVLRICKIYPSAACKAKLTKSEETVLHIAVSSYQVDEKGANALAAIIRQLVESLPVGQAVEILKAQNDKGDTALHLAAALGSVTICDCIARNRNQIYRELIMIRNRKGETPMFLAAHHGHMEAFQLLHELYNGNASEPDYSLCRRNDGDTILHSAISGEYFALADLITIKYDRLVNSVNQEGFSPLHILARKPNLFESSSHLRLCDRMLYRCVYVPEVKNRQSRRGDRRSLEETGEHYPKNYQTCVNFIRLISTAFWLIAPLGKGQDQGQRPGTEDPEEGKMEGQASDGEDSDSRQPGSTIDRETPIDGNQGLYYAFTDFLQFWNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNR1</accession>
    <name>A0A068VNR1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00003306001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG742637">
        <property type="protein sequence ID" value="CDP21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNR1"/>
    <dbReference type="Gramene" id="CDP21358">
        <property type="protein sequence ID" value="CDP21358"/>
        <property type="gene ID" value="GSCOC_T00003306001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNR1"/>
    <dbReference type="OMA" id="NEEMSNM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF70">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001659038" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="55"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="323" mass="36053" checksum="805E23EB4D9CFEB1" modified="2014-10-01" version="1" fragment="single">TIFLLVVVVGIFIRARPHTRSLENKPQEFTRNMFSAWSFDGKMVYENIIDAIENFDPKYCIGAGGFGSVFRAELPNGQVVAVKKLHGMDDGALRRPKDFANEIRALTNIRHRNIVKLYGFCSNVQHTFLVYEYLEGGSLMHLLSNDETAAKFEWIKRVSIVKDVANALSYMHQNCSPSIIHRDISSKNILLDSEYQAHISDFGTARILRPDSSHSTSFAGTYGYAAPGDFILSTLSASSSTSTVYDVLLKDIVDPRLSSPSKQESKQVTLVAKLALSCIEPNPLLRTTMKQVCVQLLKEIPSQFNVFPIVTIGQLLDLQMTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQ73</accession>
    <name>A0A068VQ73_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_7506</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00011508001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG746590">
        <property type="protein sequence ID" value="CDP21888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQ73"/>
    <dbReference type="STRING" id="49390.A0A068VQ73"/>
    <dbReference type="Gramene" id="CDP21888">
        <property type="protein sequence ID" value="CDP21888"/>
        <property type="gene ID" value="GSCOC_T00011508001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQ73"/>
    <dbReference type="OMA" id="QGENFVS"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQ73"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20618">
        <property type="entry name" value="CYP71_clan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF4">
        <property type="entry name" value="OS09G0441700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP21888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="468" mass="53384" checksum="E07DCAAE1C19F676" modified="2014-10-01" version="1">MESFSPTWAAYALAWVATVVIAHLSKHFHQQKLNLPPGPRQWPIIGNLNLIGTLPHRSLHQLSLTYGPLMHLQFGTFPVVVGSSVEMAKVFLKTMDVTFAGRPKTASGKYNSYDCTDMTWSAYGPYWRQARKIFLTELFSAKRLESYEHIRVEEMNSLLLQLFKSSGKPVVLKDYLSTGSLNVISRMVLGKTYIDESENSIVTPDEFRQMMDELFLLTGVFNIGDFIPWIDFLDLQGYIKRMKILSKKFDRFLEHVLDEHNAQRKDDTNCVSKDLVDVLLGLADDPTLEVKLERRGVKALTLDLLAGGTETSATTVEWAISELLKNPEIFNKAAEELDRVIGQNRWVNEKDMPNLPYIEAVVKETMRMHPPELFCPDRFMGKDIDFKGQDCKFLPFGAGRRMCPGYSLGLKVIQSSLANLLHGYRWKLPNDMMPEDLDMEEIFGLTTPRKIPLVAIVEPRLPRNLYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKU1</accession>
    <name>A0A068TKU1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00014124001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKU1"/>
    <dbReference type="FunCoup" id="A0A068TKU1">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TKU1"/>
    <dbReference type="Gramene" id="CDO96935">
        <property type="protein sequence ID" value="CDO96935"/>
        <property type="gene ID" value="GSCOC_T00014124001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKU1"/>
    <dbReference type="OMA" id="PANITHH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKU1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="37"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO96935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="501" mass="56457" checksum="ADF6D9CABF1C4DDD" modified="2014-10-01" version="1">MATDKAVETVIVGNYVEMETEGKPTDVKTKISKLFWHGGSAYDAWFSCASNQVAQVLLTLPYSFSQLGMMSGILFQLFYGLMGSWTAYLISILYIEYRTRKEREKVDFRNHVIQWFEVLDGLLGKHWRNVGLAFNCTFLLFGSVIQLIACASNIYYINDNLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLLMTTYTAWYLAVASLLHGQVDGVKHSGPSKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKAIYLLATLYVLTLTLPSAAAVYWAFGDMLLNHSNAFALLPRSPFRDMAVILMLIHQAGHHYFTFITFGFACTPLYFVWEKAIGMHECKSLCKRAAARLPVVIPIWFLAIVFPFFGPINSTVGSLLVSFTVYIIPALAHIFTFKSAAARENAVEQPPRFVGRWIGAYVINIFVVVWVLIVGFGFGGWASMVNFIHQIDTFGLFTKCYQCPPQQFPPPPVMNATAPLPPPPGNLTLPHHIIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM76</accession>
    <name>A0A068TM76_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014257001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM76"/>
    <dbReference type="FunCoup" id="A0A068TM76">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO97039">
        <property type="protein sequence ID" value="CDO97039"/>
        <property type="gene ID" value="GSCOC_T00014257001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM76"/>
    <dbReference type="OMA" id="CLHNCKI"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM76"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47583">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47583:SF1">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="177" mass="19806" checksum="E21E78750C148746" modified="2014-10-01" version="1">METLMEDEEYNWREVKLPSLLPIVGEPELEREQGDRRRGRDILIAVDHGPNSKHAFDWAVAHFCRLADTIHLLHVVSSLENQIVYEMTQTLMEKLCVEAFQVAMVKSFARIAEGDAGKVICREAERLKPAAVVMGTRGRGIIQSVLQGSVSEFCFHHCKVAPIIIVPGKEAGNETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN35</accession>
    <name>A0A068TN35_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase A1</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00013880001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN35"/>
    <dbReference type="FunCoup" id="A0A068TN35">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TN35"/>
    <dbReference type="Gramene" id="CDO96758">
        <property type="protein sequence ID" value="CDO96758"/>
        <property type="gene ID" value="GSCOC_T00013880001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN35"/>
    <dbReference type="OMA" id="WKLLDHE"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000065">
        <property type="entry name" value="Phospholipase A1-II 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033556">
        <property type="entry name" value="PLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828">
        <property type="entry name" value="PHOSPHOLIPASE A1-IIGAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31828:SF1">
        <property type="entry name" value="PHOSPHOLIPASE A1-IIGAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="134"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO96758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="396" mass="44505" checksum="D30A2049DB13D30C" modified="2014-10-01" version="1">MDSIAKRWKVLSGNYDWDGLLDPLDYDLRRYIIHYGEMAQATYDSFNAEKASRYAGSCLYAKKDLFAKVGLQNGNPFKYRVTKYLYATSSIQLPDAFIVKSFSREAWSKESNWMGYVAVATDEGKVALGRRDIVIAWRGTVRSLEWVNDLEFVSVSAPKIFTENDDDPKVHQGWYSIYTTDDSRSPFNKISARDQVLDEIRRLVEEFKGEEISITVTGHSLGAAVATLNAVDIVANGFNKSVQNPGKACPVTAFVYASPRVGDQGFEKVFSQQQNLKVLRIRNSLDVVPNYPLLGYADVGEQLGIDTTKSKYLKSPGNLSSWHSLECYMHGIAGTQGLQGGFKLVANRDVALVNKHMDALKDEHCVPVSWWCIQNKGMVQQSDGSWKLEDHEDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN41</accession>
    <name>A0A068TN41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014787001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TN41"/>
    <dbReference type="STRING" id="49390.A0A068TN41"/>
    <dbReference type="Gramene" id="CDO97442">
        <property type="protein sequence ID" value="CDO97442"/>
        <property type="gene ID" value="GSCOC_T00014787001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TN41"/>
    <dbReference type="OrthoDB" id="1631570at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TN41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="7573" checksum="01BD0209E7B62466" modified="2014-10-01" version="1">MFVQSKEQPGEFRWQPGSVTQAICNGFWVVVEDVDKASPDVQSILLPLLEGASSFITGHGEAIRVHKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNE8</accession>
    <name>A0A068TNE8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00014059001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNE8"/>
    <dbReference type="STRING" id="49390.A0A068TNE8"/>
    <dbReference type="Gramene" id="CDO96888">
        <property type="protein sequence ID" value="CDO96888"/>
        <property type="gene ID" value="GSCOC_T00014059001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNE8"/>
    <dbReference type="OMA" id="KYRPDEN"/>
    <dbReference type="OrthoDB" id="1938112at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNE8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000217">
        <property type="entry name" value="probable LRR receptor-like serine/threonine-protein kinase At1g53430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000452">
        <property type="entry name" value="Probable LRR receptor-like serine/threonine-protein kinase RFK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000004">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000044">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF66">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654050" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="35"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="688"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDO96888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113087" checksum="11E09378814BD39D" modified="2014-10-01" version="1">MAERTISHSSSQIILVFLLIFSIVLLFQASCSEAQSGFLPEQEVDALKEIASQLGKKDWNFSLNPCDGNSNWNTSRRIDMPLYNNSVICNCSFPGGVCHVTKIFRFQSLSCYLILCHRFLKGQNLQGVLPPSLAKLPYLNTIDLTRNYLSGTIPLEWASTQLEYLSVIVNRLSGPIPGYLGNLKTLVYMSLENNMFNGTVPAELGKLVNLENLILNANNLTGQLPKELNNLTKLTELRLSSNNFTGNLPDFSSWKNLTKLELQASGFQGPIPPSISVLKNLTELRISDLGGGASDFPLLRDMTSMQKLMLRSCNLVGKIPYYIINMMTLQTLDLSFNKLEGEVPNLEGLEGLQFMYLTRNSLSGTIPDWITGRDTQHQIDLSYNNFSESSEPSTCRETLNLFKSFTGGKTSELGKCLLQSFPCSKDYYSLHVNCGGKSTVIGNKVFEADEDSAGAAKFVPSKENWGTSSTGDFWDVTTSIANYTANNVSVLRVNDSDLYTTARLSPLSLTYYGRCLANGNYTVTLYFAEIILRDDQSFQSLGRRMFDVYVQDERKLKDFNIEKEAQGVDRVAKEEYTGVVVKDGILEIRFHYSGKGSTAVPTRGTYGPLISAISVVSEFNPPSKGKKKIFIAVGTVASTLLIVLSILGFAWRRWHSRQKISREEELRGLDLRTGLFTYRQIKAATDNFSATNKIGEGGFGAVYKGMLLDGTVIAVKQLSPKSKQGNREFVNEIGMISGLLHPNVVRLYGCCIEGDQLLLVYEYLENNNLARALFGPQDLQLELDWSTRQKICIGIAKGLSFLHDESALKIVHRDIKTNNILLDKELNPKISDFGLAKLVEEENTHISTRVAGTIGYMAPEYALWGYLTYKADVYSFGIVALEIVAGKSNMSYRPSEDYVCLLDWALVLQQRGSLVELVDPRLGSNINEGEAIRMIKVALLCTNPSPALRPTMSAALGMLEGRISTQEFSSDPSVYNDGLNLQGLRDKYDELQFSSIEPQSFSTSSDTKESSALTSSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPR6</accession>
    <name>A0A068TPR6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSCOC_T00022226001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
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            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="18"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPR6"/>
    <dbReference type="STRING" id="49390.A0A068TPR6"/>
    <dbReference type="Gramene" id="CDO98206">
        <property type="protein sequence ID" value="CDO98206"/>
        <property type="gene ID" value="GSCOC_T00022226001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPR6"/>
    <dbReference type="OMA" id="MYDNKSY"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPR6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000045">
        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDO98206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="956" mass="105778" checksum="5892C3D2E99134D0" modified="2014-10-01" version="1">MADNRSISLEEIRKENVDLESIPVQEVFEQLNCSREGLTTQEAQQRLQIFGPNKLEEKKAIFICSESKILKFLGFMWNPLSWVMEAAAVIAIALANGQGKPPDWQDFLGIIILLVINSTISFVEENNAGNAASALMAGLAPKTKVLRDGRWMEQEAAILVPGDIISIKLGDIIPADARLLEGDPLKIDQSALTGESLPVTKNPADEVFSGSTCKQGEIEAVVIATGINTFFGKAAHLVDSTNQVGHFQKVLTAIGNFCICSIAVGIMVEVVVMFPIQKRRYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLIEVFTKDVDRDTVILLGARASRVENQDAIDACIVGMLADPREARADITEVHFLPFNPVDKRTAITYFDSRGDWYRVSKGAPEQIADLCGLREDMKRKLHSIIDKFADRGLRSLATVPEKTKEGQGGPWVFVGLLPLFDPPRHDSGETIKRALHLGVNVKMITGDQLAIAKETGRRLGMGINMYPSSSLLGQHKDETISNLPVEELIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIVSAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLIALIWKFDFSPFMVLIIAILNDGTIMTISKDKVRPSPMPDSWKLREIFATGIVLGTYLAVMTVIFFWAAQGSNFFSDKFGVRSIRDKHHELNSALYLQVSIVSQALIFVTRSRSWSFVERPGLLLVGAFVVAQLIATLIAVYANWEFAYIHGIGWGWAGVIWLYSVIFYIPLDVMKFFIRYCLTGRAWNNLLQNKTAFTTKKDYGRGEREAQWALAQRTLHGLHPPENSDILNDKNNYRELSEIAEQAKKRAEVARLRELHTLKGHVESVVKLKGLDIETIQQHYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPW3</accession>
    <name>A0A068TPW3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MAR-binding filament-like protein 1-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022043001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPW3"/>
    <dbReference type="Gramene" id="CDO98067">
        <property type="protein sequence ID" value="CDO98067"/>
        <property type="gene ID" value="GSCOC_T00022043001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPW3"/>
    <dbReference type="OMA" id="NVKTHFI"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="54"/>
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        </location>
    </feature>
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            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="79720" checksum="0E6C9B9022956A01" modified="2014-10-01" version="1">MGQNRRKRTRISAYMSQETGNERSSGARRFVLFVGFSVIPVLKLTAKAFESWPQDGSDLKSVEQDRRAEQKHQGDASHNPFVSLLSGLGILGSGVLGALYMLSLKEKATSEAAIESMRTKLKEKEAAIVSMEKKFRSDLMNEKESRNQQVTKFHEEQRSLVSKLKSANDTVVGLGQELQKERKVIGELKATIDGLQTDLVKAREDKKEIQEKLTEKLESLGVLQEKTNFLSGEIKDKDDTIQSLSSALAKKELELEKLNSIYQQLQDQFAGLNSENEELKDKLLKNENELELKTAAVDDLNVQVGMLIAEKEESKRKFDAIKGEYNDLKSSSMKKAAEDAKLLEMQDLKLQQLEEQLESTSSEVSRSKLQIAGLSKERDDLRNTLDVELNKLESLEQELQTTLVNLEKSRNEASGLASQLQLARELCLELEVEVSKVRADFAETKETLQKKAEEARRDAEVLAGELTSVKELLKEKTEEILNVSNELAAVVQTRDELQKELVDVYKKAESAANDLNEEKAIVASLNKELKALDTRVCKESEARKSLERNLEEATRSLNEINQNALILSRELELANSQISSLEDEKDALYKSLGEQKQVSQEARENMDDAHSLIRQLGQERESSERRAKKLEEELAAAKGEILRLRSRINSSKTNVNDQHQQTVEVGAKAAAPVKRVARRRKALHLIEIIECNHLVCKFWNIHSDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPW6</accession>
    <name>A0A068TPW6_COFCA</name>
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        <recommendedName>
            <fullName evidence="10">Glutamate/malate translocator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014754001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068TPW6">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPW6"/>
    <dbReference type="Gramene" id="CDO97413">
        <property type="protein sequence ID" value="CDO97413"/>
        <property type="gene ID" value="GSCOC_T00014754001"/>
    </dbReference>
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    <dbReference type="OMA" id="YAWHFFA"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPW6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015131">
        <property type="term" value="F:oxaloacetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42826">
        <property type="entry name" value="DICARBOXYLATE TRANSPORTER 2.1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="449"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="482"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022780"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60032" checksum="A76C0F8C69014CDD" modified="2014-10-01" version="1">MESSVLHSPFLSSTSFSRVSIHHLRPRFSTALPPVSSSLKPPLLSISAPKFSLQNFFPSPPKLLYKKLSPPHSSTNDSAPSTTELKTVALQGAKIIPLIISVSIGLIVRFLVPKPPEVTPQAWQLLSIFLSTIAGLVLSPLPVGAWAFLGLTTAILTRTLPFTIAFSAFTNEVIWLIVISFFFARGFVKTGLGDRIATYFVKWLGKSTLGLSYGLTLSEALIAPAMPSTTARAGGVFLPIIKSLSLSAGSKPGDPSARKLGAYLVQSQFQSAGNSSALFLTAAAQNLLCLKLAEELGVVIASPWVSWFKAASLPAFVSLIATPLVLYKLYPPETKDTPDAPAMASKKLEVMGPVTRNEWVMVGTMLLAVSLWVFGDALGVASVVAAMLGLSILLLLGVLDWDDCLSEKSAWDTLAWFAVLVGMAGQLTNLGIVSWMSCCVAKILQSLSLSWPAAFGVLQAAYFIIHYLFASQTGHVGALYSAFLAMHLASGVPGVLAALALAYNTNLFGALTHYSSGQAAVYFGAGYTDLPDVFKFGFIMALINALIWAVVGTFWWKLLGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPZ6</accession>
    <name>A0A068TPZ6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00022466001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPZ6"/>
    <dbReference type="FunCoup" id="A0A068TPZ6">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98390">
        <property type="protein sequence ID" value="CDO98390"/>
        <property type="gene ID" value="GSCOC_T00022466001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPZ6"/>
    <dbReference type="OMA" id="ACSISYW"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPZ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="495" mass="54013" checksum="52DAFF0F65B94C0D" modified="2014-10-01" version="1">MQREHEEQAILNAPLVNTSEKVGWKGGLCDQENSFNKKEIVEEVKKQIWLAGPLICVSLLQFSLQIISVMFVGHLGELALSAASMATSFASVTGFSLLMGMSSALDTFCGQSYGAKQHHMLGIHMQRAMIVVLLVSIPLAVVWGNTGHILKFLGQDPQISDQAGVFAKFIIPSLFGYGLLQCHVRFLQSQNIVFPMMLTSGITTLLHVLVCWLLVFKSDLGFKGAALANGISYWINLLLLAFYVKFSTSCKKTWTGFSKEALHNIPNFLKLGIPSTIMICLENWSFEMTVLLSGLLPNPQLETSVLSVCLNTAATVWMIPFGLSCAVSTRVSNELGAGHPRTARLAVCVVFFMALTVGILVGLVLILIRNGLGYAFSNEKEVVNYVARMVPLLATSNLLDGLQCVLSGTVRGCGWQKIGAFINLGSYYLVGIPAAVLIAFVLHIGGQGLWSGIICALIVQVLCLFIITWRTNWEKEAKKALERVHDSIIPVETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ12</accession>
    <name>A0A068TQ12_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022103001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ12"/>
    <dbReference type="FunCoup" id="A0A068TQ12">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ12"/>
    <dbReference type="Gramene" id="CDO98107">
        <property type="protein sequence ID" value="CDO98107"/>
        <property type="gene ID" value="GSCOC_T00022103001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ12"/>
    <dbReference type="OrthoDB" id="1913905at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ12"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34198:SF1">
        <property type="entry name" value="OS01G0104300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34198">
        <property type="entry name" value="OS01G0175100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="204" mass="22938" checksum="CA5D798583449C16" modified="2014-10-01" version="1">MFLFISICHAYNLIRFPKKHPFLPSFSLTSLFHPHFIILLEKFFFFFCGFSKPSKASSELLFGLMLMATTPFAHFPTSPVICSASPQPNHHPKHNPTRQKLSPSPSNWWPPLFGWSSDPDYIQGSNSESNQESGEIQGHPGREASGRPTRSKFGLGCFTEEKAKELRKKTMESSTFHDIMYHSAIASRLASDASASGTGLRQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQU0</accession>
    <name>A0A068TQU0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00015120001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQU0"/>
    <dbReference type="FunCoup" id="A0A068TQU0">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQU0"/>
    <dbReference type="Gramene" id="CDO97703">
        <property type="protein sequence ID" value="CDO97703"/>
        <property type="gene ID" value="GSCOC_T00015120001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQU0"/>
    <dbReference type="OMA" id="AMETFTV"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQU0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19492">
        <property type="entry name" value="Rad51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001318">
        <property type="entry name" value="DNA repair protein RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="12">
        <location>
            <begin position="85"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO97703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="347" mass="38066" checksum="F949E2C092AA0D19" modified="2014-10-01" version="1">MEVSSLPISASHRAKLISAGYISISSLSSISPAHLARDLGISENEATGILKVASQRGGLGRTIPSHHSIVDGAQTAWDMLHEEESCRRITTSCADLDDILGGGISCKEVTEIGGVPGIGKTQLGIQLAINVQIPLEYGGLAGKAVYIDTEGSFMVERVQQVAEACIKDMQEYDSFLRKDLPARQVDLQANDFLANIYYFRICSYTEQIAVINYLEKFISEHKDIKVVIVDSITFHFRQDFDDMALRTRLLGGMALKLMKLAKKFTLAVILLNQVTTKYSGGSFQLTLALGDSWSHACTNRIILYWNGNGRYAHIDKSPSIRSASAPYAVTGRGIRNLASNCKRVKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR68</accession>
    <name>A0A068TR68_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00025724001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR68"/>
    <dbReference type="FunCoup" id="A0A068TR68">
        <property type="interactions" value="3295"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TR68"/>
    <dbReference type="Gramene" id="CDO98800">
        <property type="protein sequence ID" value="CDO98800"/>
        <property type="gene ID" value="GSCOC_T00025724001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR68"/>
    <dbReference type="OMA" id="QNEFNFG"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR68"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000002">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000040">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO98800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="530" mass="58841" checksum="EC5B9D28A15EEE79" modified="2014-10-01" version="1">MSLRPTERTEVRRNRYKVAVDAEEGRRRREDQMVEIRKSKREENLLKKRREGLQMSQPFPAPVPSNNIEKKLESLPLMVNGVYSNDNNLQLEATTQFRKLLSIERSPPIEEVIQSGVVPRFVEFLMREDFHQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSPSDDVREQAVWALGNVAGDSPRCRDLVLGHGALIPLLAQLNEHAKLSMLRNATWTLSNFCRGKPQPPFEQVRPALPALQRLVHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVELLVHPSPSVLIPALRTVGNIVTGDDYQTQCIIDHGALPCLLSLLTHNHKKSIKKEACWTISNITAGNKEQIQAVIEAQLIGPLVNLLQTAEFDIKKEAAWAISNATSGGTHEQIKYLVSQGCIKPLCDLLVCPDPRIIAVCLEGLENILKVGEVEKSLGHSGDVNFYAQLIDEAEGLEKIEHLQSHDNNEIYEKAVKILETYWLEEEDETLPAGDGGQPGFNFGGNDMQLPPGGFKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR92</accession>
    <name>A0A068TR92_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3511 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021827001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR92"/>
    <dbReference type="STRING" id="49390.A0A068TR92"/>
    <dbReference type="Gramene" id="CDO97888">
        <property type="protein sequence ID" value="CDO97888"/>
        <property type="gene ID" value="GSCOC_T00021827001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR92"/>
    <dbReference type="OMA" id="MEAYYGS"/>
    <dbReference type="OrthoDB" id="1655903at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021899">
        <property type="entry name" value="DUF3511"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33193">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF3511)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33193:SF71">
        <property type="entry name" value="OS02G0223700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12023">
        <property type="entry name" value="DUF3511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14851" checksum="E383FAD138A70C1A" modified="2014-10-01" version="1">MEKYTRSKSTREGRMQRGEDGYYGDGAASAVAGPPSMHELRSYSTSYTSYTQPLPPPPQPPAYVQDLTKDGKMKKSKSRVASSSKSWSFSDPELQRKKRVVSYKAYAVEGKMKGSFRKSFRWIKDVVHGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TRU8</accession>
    <name>A0A068TRU8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small ribosomal subunit protein bS1c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">30S ribosomal protein S1, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00025628001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TRU8"/>
    <dbReference type="FunCoup" id="A0A068TRU8">
        <property type="interactions" value="1185"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TRU8"/>
    <dbReference type="Gramene" id="CDO98727">
        <property type="protein sequence ID" value="CDO98727"/>
        <property type="gene ID" value="GSCOC_T00025628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TRU8"/>
    <dbReference type="OMA" id="YDYHFSP"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TRU8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05687">
        <property type="entry name" value="S1_RPS1_repeat_ec1_hs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04465">
        <property type="entry name" value="S1_RPS1_repeat_ec2_hs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05692">
        <property type="entry name" value="S1_RPS1_repeat_hs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000078">
        <property type="entry name" value="30S ribosomal protein S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000102">
        <property type="entry name" value="30S ribosomal protein S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000162">
        <property type="entry name" value="30S ribosomal protein S1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO98727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="429" mass="46495" checksum="3661CF8FF6207027" modified="2014-10-01" version="1">MASLAQHFGGLKRPPLSTILNTNSNNRCSTHCLNSPKQNHQQQQPRRGLVLVVAAAAGPVAVSNAQTRERMKLKEIFEDAYDRCRTAPMEGVAFTLENFHAALDKFDFDSEIGSRVKGTVFAVDANGALVDITAKSSAYLPVSQASIYRIKSVEEAGIVPGLCEEFEVIGEIEADDSLILSLRAIQYELAWERCRQLQAEDVVVKGKVTGANKGGVVALVEGLVGFVPFSQISTKSTAEELLEKELPLKFVEVDEEQSRLILSNRKAMADSQAQLGIGSVVLGTVQSLKPYGAFIDIGGINGLLHVSQISHDRVSDIATVLQPGDTLKVMILSHDRERGRVSLSTKKLEPTPGDMIRNPKLVFEKAEEMAQTFRQRIAQAEAMARADMLRFQPESGLTLSSDGILGPLTSDLPAEGLDLSDIPPADDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSV7</accession>
    <name>A0A068TSV7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="11">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00026531001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>indole-3-pyruvate + NADPH + O2 + H(+) = (indol-3-yl)acetate + CO2 + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:30854"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.168"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Plant hormone metabolism; auxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="11"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSV7"/>
    <dbReference type="SMR" id="A0A068TSV7"/>
    <dbReference type="STRING" id="49390.A0A068TSV7"/>
    <dbReference type="Gramene" id="CDO99380">
        <property type="protein sequence ID" value="CDO99380"/>
        <property type="gene ID" value="GSCOC_T00026531001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSV7"/>
    <dbReference type="OMA" id="IMHACDY"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSV7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103075">
        <property type="term" value="F:indole-3-pyruvate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009851">
        <property type="term" value="P:auxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000100">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF49">
        <property type="entry name" value="INDOLE-3-PYRUVATE MONOOXYGENASE YUCCA7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0073">Auxin biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO99380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="417" mass="46476" checksum="8CEEF9F25508C049" modified="2014-10-01" version="1">MADASEHDELFAGRRILVNGPVIVGAGPSGLAVAAGLQQQGVPFIILERASCIASLWQNRTYDRLKLHLPRQFCELPYFPFPKEFPEYPTKNQFIDYLESYAKHFKIIPRFNESVQSAKYDQKCGSWRIKTVVASDNSEIEYICSWLVAATGENAEKVVPEFEGLQDFGEVMHVCDYKSGEAYEGKRVLVAGCGNSGMEVSLDLCNYNAMPSMVVRSSVHVLPREILGLSTFQLAVSFMKWLPVWLVDKILVTATRLILGNLEKYGIKRPSTGPLELKNTEGKTPVLDIGTLDKIRSGKIRIVPGIKKFFRGGVELENGEFLEIDSVILATGYRSNVPSWLKENEFFSVDGFPKTPFPNGWKGKAGLYAVGFTRRGLSGASFDAIRVSKDIGQIWKQELKQKNQGALSLANRRTCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU16</accession>
    <name>A0A068TU16_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00025779001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU16"/>
    <dbReference type="FunCoup" id="A0A068TU16">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU16"/>
    <dbReference type="Gramene" id="CDO98843">
        <property type="protein sequence ID" value="CDO98843"/>
        <property type="gene ID" value="GSCOC_T00025779001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU16"/>
    <dbReference type="OMA" id="GMMLSEW"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="502" mass="54963" checksum="0C1AF63048A034D5" modified="2014-10-01" version="1">MEAEQTKKSPTVSEVIEELKKMKDISFPIFAIGLAGYLKNMISVTCMGRLGSLELAGGALAIGFTNITGYSVLSGLAMGMEPLCSQAFGSRNTSIASLILRRTILMLLVASLPIGLLWINLKPLMLRLHQDPEVVDISSIYCRFAIPDLIANSLLHPIRIYSRSKGITWPLLWCTLLAIILHLPITTFLTFNLHLGIQGIAISISVANFNTLFFLLAYLLYYTYAPSEALSKPLAPKSNSTSLGEDWRMLLRLSLPSCLAVCLEWWWYEIMTLLAGYLERPQVALATSAIVIQTTSLMYTLPSALSASISTRVGNELGAGRPYKARLATVVGIGLAFITSVFGFLLTTIGREAWGRIFTKDTEVLELTLATLPIIGLCELANCPQTTCCGVLRGTARPCTAAGINFYSFYLMGTPVAIALAFFWGQGFLGLCYGLLAAQVACMVSILTVISKTDWERESQKAVDLVGETCENRYQDEIAKCEEGHNSQKQNSFEKANGLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUV1</accession>
    <name>A0A068TUV1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00029393001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUV1"/>
    <dbReference type="STRING" id="49390.A0A068TUV1"/>
    <dbReference type="Gramene" id="CDO99719">
        <property type="protein sequence ID" value="CDO99719"/>
        <property type="gene ID" value="GSCOC_T00029393001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUV1"/>
    <dbReference type="OMA" id="IYKGFKC"/>
    <dbReference type="OrthoDB" id="4206278at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUV1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000029">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325:SF20">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654297" description="CRIB domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="3">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="237" mass="26576" checksum="530D09290C637CD4" modified="2014-10-01" version="1">MLIAIIACIYVHFVLKGDGDCRRKKGKRISFSFEPPFSPYRIKPFLKRQRNKFYTLLWFFHLFRVLDPTRGLLNSTCTAFFMGTKMKGICKGFNKYISQMFVVKEREMEIGYPTDVKHVAHIGWDGPSGSAPSWMNEFKTGPDFTATSIGNSGSALSPWSSQDFGESMGHRSTSEMYKDIPSTDLPNIPKAKQKRKKSKSTSSPRSNSSSSSRGSRAAKSKTKFVEGNAKPANIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUW1</accession>
    <name>A0A068TUW1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00029875001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUW1"/>
    <dbReference type="STRING" id="49390.A0A068TUW1"/>
    <dbReference type="Gramene" id="CDP00085">
        <property type="protein sequence ID" value="CDP00085"/>
        <property type="gene ID" value="GSCOC_T00029875001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUW1"/>
    <dbReference type="OMA" id="LHCKDCE"/>
    <dbReference type="OrthoDB" id="1110082at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUW1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45868">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45868:SF93">
        <property type="entry name" value="OS12G0144600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP00085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="279" mass="29437" checksum="7495E24F725C645D" modified="2014-10-01" version="1">MAYSLPLVAPSNFILKLKIHCSKCENKLKRMLLRVAGVHSVSIDAKQGTVAISGNVEPSTILMLLEKGVGRKAELLWEQSPSASSTSSKLDGQNLEIIAESKVVDELFNDPNVVAQLERLSGIQGLTNIQVTYSKTIKLSFKGEKDDLSDKNVQVTARDQGSGIFCEASASCCGGHNHGGVNRNVHGYGIGGCCGNHAAGYPIASYVCPVHSCDGNSYWPPHACGSVPPPAPQPPCPGCSPSAPPLGTTYDTPPPPTSMGYSYFSPFSDDNLSSGCNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVN0</accession>
    <name>A0A068TVN0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00029775001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVN0"/>
    <dbReference type="STRING" id="49390.A0A068TVN0"/>
    <dbReference type="Gramene" id="CDP00019">
        <property type="protein sequence ID" value="CDP00019"/>
        <property type="gene ID" value="GSCOC_T00029775001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVN0"/>
    <dbReference type="OMA" id="LVEWAMK"/>
    <dbReference type="OrthoDB" id="640180at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVN0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000005">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000252">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000001">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF62">
        <property type="entry name" value="OS05G0423500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657361" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="25"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="486"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP00019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="824" mass="91806" checksum="E757A02C817A10EF" modified="2014-10-01" version="1">MRISTYQFLIRVLLPFCLVLTSLEFDPEDKYLIDCGSLDDTSVGDRVFLADSLNSSTLSTPEKIFLNASSNSIPSTYGRALYRTARIYNGTSRYSFTMKKTGRHWIRLYFFPFVNQYLNLSTSKFSVSAQNFTLLKDFQPSGAPTVKEYSLNLTDNILVLTFTPSTNSFAFLNALEVISLPNELIPSGAKTVDSNGENRNLERQALETVARINMGNETVPPQNDTLWRLWTSDSTYLASSALVVFVSNIGFVNYSSGRVSENIGPFSVYGTATKLNTASDERYMINATWLFHVDHGFDYFVRFHFCNILNPVPDNLYFNVFLNYDFAAKDLNLSTSGVPHYMDVVTRADSVDQLSVSIGTSSVQNALPNGILNGLEIMKISNSKDSLDASDAESQFKATTSKSKVWVYVGSALGLSVIVIVLVLVFALLCRGRRRKHMVHSTLDQYAMTGVSTEEKEHSIESSIISQSKRGYRFPFAAVQVATDNFSESQLIGVGGFGKVYKGALSDGTKVAVKRGFPQSRQGVAEFKTEIEMLSQFRHRHLVSLIGYCDERNEMIIIYEYMENGTLKDHLYGSDQPKLNWRHRLQICIGSARGLHYLHTGSNKAIIHRDVKSANILLDENLMANVADFGISKTGPEFDQTHVSTAVKGSFGYLDPEYLTTQQLTDKSDVYSFGVVMIEILCGRPVIDPSQPRERVNLVEWAIKCFSIGEMETLVDPHIEGQAKPESLMKFKETALKCLADLGANRPPIGDVLWNLEAALQLQGSDQREGNEQSANLYSETRVSTAQFSMGSVDGLAGVSMRRVFSQMVRAENAVDQSQKDTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW41</accession>
    <name>A0A068TW41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00032441001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW41"/>
    <dbReference type="FunCoup" id="A0A068TW41">
        <property type="interactions" value="822"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TW41"/>
    <dbReference type="Gramene" id="CDP00486">
        <property type="protein sequence ID" value="CDP00486"/>
        <property type="gene ID" value="GSCOC_T00032441001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW41"/>
    <dbReference type="OMA" id="CSISCAR"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW41"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE-RELATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="160"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="641" mass="71232" checksum="BE8D0C7C63D0D608" modified="2014-10-01" version="1">MSPNLDSPVQTQMAVAVFKSPIAGEYHGNNRMEGKAAGRRRVFVQTDTGCVLGMELDRSDNAHTVKRRLQLALNVPTEESSLTFGDMVLKNDLSAIRNDSPLLLTRNLLHRSSSTPCLSPTGRDIQHRDQSGLIEILGHSGSFSKTKQLVKEIVKAIKAGVDPLPVHSGLGGAYYFRNNRGESVAIVKPTDEEPFAPNNPKGFVGKALGQPGLKRSVRVGETGFREVAAYLLDYDHFANVPPTALVKITHSIFNVNDGVGSSKPQNKKLVSKIASFQQFIPHDFDASDHGTSSFPVAAVHRIGILDVRIFNTDRHAGNLLVRKLDGVGRFGQVELIPIDHGLCLPESLEDPYFEWIHWPQASIPFSDDELEYIEELDPIRDSEMLRTELPMIREACLRVLVLCTIFLKGAASYGLCLAEIGEMMTREFRGGDEEPSELEVVCIEARRLIAEREMLSPKAEGHDEEFQFDIDCEDDIYKIDPKMVSEDFMVGSPFHFGFGGVIGRSPLSKLEESVEEEDESDVEEEEDDFVGVLGPARNSNISKLSMSLKNTSFGEKNQKFSKLSGTKPEYGYLTSSSSGHRSANEQLPVSASFVKLADMNDEEWAMFLEKFQELLYPAFADRKSITLGHRQRQRLGTSCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWH2</accession>
    <name>A0A068TWH2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00029338001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWH2"/>
    <dbReference type="STRING" id="49390.A0A068TWH2"/>
    <dbReference type="Gramene" id="CDO99673">
        <property type="protein sequence ID" value="CDO99673"/>
        <property type="gene ID" value="GSCOC_T00029338001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWH2"/>
    <dbReference type="OMA" id="LIICCEE"/>
    <dbReference type="OrthoDB" id="785331at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase At4g03230"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR021820">
        <property type="entry name" value="S-locus_recpt_kinase_C"/>
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        <property type="entry name" value="S_locus_glycoprot_dom"/>
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    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1097">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11883">
        <property type="entry name" value="DUF3403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="214"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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            <dbReference type="ARBA" id="ARBA00048679"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDO99673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="532" mass="60662" checksum="9434A5DD57A097EC" modified="2014-10-01" version="1">MSGTMLPGMKLGCNLKTGTSNIMRSWKNFDDPSHGEFTFSLDPPETPQLILRQGETKKYRWGPFDGDRFSGSNELRNNTVFKPIFVSTSDEVYYAYETLDDSTLVRSVVTPLGSIQYLTWRNTSRDWNMIVELNRIYYSIAENKRRKRIRVAIGISISTAFLLVLLAMAWQMMKRVKRRAEEDTVSMPIEESQDEDLELPIFGLATIVDATDQFAFGNKIGQGGFGPVYKGKLPNGSEIAVKRLSQDSGQGLREFQNEVKLIANLQHRNLVKLLGCCIQGEEKMLVYEYLPNKSLDNFIFDRVKRKLLPWNTRFDIVLGIARGLLYLHQDSRLRIIHRDLKTSNILLDIKMNPKISDFGTARIFGGEQTEEKTRRVIGTYGYMSPEYAMSGHFSIKSDVFSFGVIVLELISGRKNWGFYDPGHDYNLIGHTWKLWNEDRCLELVDEMLDGSFSIKEVIRCIQVALLCVQQRAEDRPAMSTVVFMLSNENVELPQPKEPGFITENSPFKNDPSWSGQDSNTGNELTITAVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY52</accession>
    <name>A0A068TY52_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00034491001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CDP01007"/>
        <property type="gene ID" value="GSCOC_T00034491001"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="207175at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY52"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2/ERF domain"/>
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        <property type="entry name" value="AP2/ERF_dom"/>
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    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
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    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF157">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR CRL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="62"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP01007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="314" mass="34785" checksum="C064B4FAF3B3F3BA" modified="2014-10-01" version="1">MEEKAARAYDLAALKYWGPSTHINFPLENYQQELEGMKNMSRQEYVAHLRRKSSGFSRGASIYRGVTRHHQHGRWQARIGRVAGNKDLYLGTFSTQEEAAEAYDIAAIKFRGVNAVTNFDISRYDVERIMASNTLPAGELARRNKETEPNNETIAYANAAHKSEECFQPERNANVSDWKMAPYQPPQQQQNLPMDSFNEKIMNVVHYQNPSYSTALHGLIGIDSGNSSRGIVDESAKLGAHFSNSSSLVTSLNSSREASPDRSGTSMLFAAKPTSAANYVNPTANVGSWIPSAQLKPVPISMAHLPVFAAWGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYZ1</accession>
    <name>A0A068TYZ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00034821001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYZ1"/>
    <dbReference type="STRING" id="49390.A0A068TYZ1"/>
    <dbReference type="Gramene" id="CDP01242">
        <property type="protein sequence ID" value="CDP01242"/>
        <property type="gene ID" value="GSCOC_T00034821001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYZ1"/>
    <dbReference type="OMA" id="IVWASYG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYZ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20653">
        <property type="entry name" value="CYP81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000023">
        <property type="entry name" value="Cytochrome P450 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF3">
        <property type="entry name" value="CYTOCHROME P450 81D1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP01242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55868" checksum="554FE321CAE5EE56" modified="2014-10-01" version="1">MEISYYLLLIPLLYFLTNQIIKRFNNLPPSPFPSLPVIGHLHLIKNPVHRTLAQISSKYGRVLLLYFGSRPVLLISSPSAAVECFTKNDIVFANRPKFLAGKYLGFNYTTLVWASYGQHWRNIRKIATVYILSGRRVQMFKHIRSEEVHLLIRRLLKAAAASDDDHVMVDMKSAFFELTLNIMMRMIAGKRYSGDGSGKIEEVTSFQEMVKESLKVSGSTNAADFVPLLRWIGQNKLESHLKTLQMKREKFLQYLIEKHRSISSHRENKTLIDVLLSHQETEPEYYTDQIIRGLVQIMLSAGSDTTSGTMEWALSVLLNNPEALKKAQEEIDVQIGQSRLITDSDLGQLPYLQAIINETFRMYPVSPFISLHESSEECTVEGFGIPRGTLLLVNLWAINYDPEIWEEPTKFKPERFEFMPFGLGRRGCPGENFARRVVGLALGSLIQCFEWERPGEELVDMSEGAGHTMPRAQPLLAKYRPRPEMVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZC7</accession>
    <name>A0A068TZC7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00036768001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZC7"/>
    <dbReference type="FunCoup" id="A0A068TZC7">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZC7"/>
    <dbReference type="Gramene" id="CDP01650">
        <property type="protein sequence ID" value="CDP01650"/>
        <property type="gene ID" value="GSCOC_T00036768001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZC7"/>
    <dbReference type="OMA" id="DCSLCRR"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZC7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="141" mass="15711" checksum="ED80ACDEC5FC6F24" modified="2014-10-01" version="1">MNPEMVIHNGGCHCKSVRWRVQAPASIVVWQCNCSDCSMRGNTHFIVPSIRFELLGDSKQFLTTYTFGTHTAKHTFCKICGITSFYVPRSNPDGIAVTFRCVDPGTLNHVEIKQIDGRNWEDSVSQTGIAACSKVLDKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0D0</accession>
    <name>A0A068U0D0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma carbonic anhydrase 1, mitochondrial-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037197001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0D0"/>
    <dbReference type="STRING" id="49390.A0A068U0D0"/>
    <dbReference type="Gramene" id="CDP01995">
        <property type="protein sequence ID" value="CDP01995"/>
        <property type="gene ID" value="GSCOC_T00037197001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0D0"/>
    <dbReference type="OMA" id="ACTLEDE"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0D0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000012">
        <property type="entry name" value="Carnitine operon protein CaiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF50">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP01995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29380" checksum="8484E9E9B2759BA4" modified="2014-10-01" version="1">MGSLGRAIYTVGFWIRETGQALDRLGCRLQGNYYFQEQLSRHRTLMNIFDKAPVVDKDAFVAPSASIVGDVQVGRSSSIWYGCVLRGDVNSISIGTGTNIQDNSLVHVAKSNLSGKVLPTIIGDNVTVGHSAVLHGCTVEDEAFVGMGATLLDGVVVEKNAMVAAGALVRQNTRIPCGEVWGGNPAKFLRKLTDEEIAFISQSALNYSNLAQVHAAENAKGFDEIEFEKVLRKKFARKDEEYDSMLGVVRETPPELILPDNVLPDKAPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0X9</accession>
    <name>A0A068U0X9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039468001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0X9"/>
    <dbReference type="FunCoup" id="A0A068U0X9">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP02161">
        <property type="protein sequence ID" value="CDP02161"/>
        <property type="gene ID" value="GSCOC_T00039468001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0X9"/>
    <dbReference type="OrthoDB" id="46836at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0X9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF17">
        <property type="entry name" value="CELLULAR REPRESSOR OF E1A-STIMULATED GENES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657238" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="177" mass="18849" checksum="C7570D55E6FB3F51" modified="2014-10-01" version="1">MKGVQRGVNAHGVVLLLVVVVLLQKAVLGRPLQLQQLTAVTRPSPKDTAAFARWLVCQSSWGVLSTIASDLGGAPFGNVVSFSDGQPDKGSGIPYFYLTTLDPTARYALKDQRSSLTISEHPIGTCGTKDPENPSCAKITLVGKLTLLDGNSKEAELAQTALFTKHPEMTGKLVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0Y7</accession>
    <name>A0A068U0Y7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication factor C C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037199001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0Y7"/>
    <dbReference type="STRING" id="49390.A0A068U0Y7"/>
    <dbReference type="Gramene" id="CDP01997">
        <property type="protein sequence ID" value="CDP01997"/>
        <property type="gene ID" value="GSCOC_T00037199001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0Y7"/>
    <dbReference type="OMA" id="KVQNDAW"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0Y7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF25">
        <property type="entry name" value="OS02G0704966 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="81819" checksum="65C979C0720C32B3" modified="2014-10-01" version="1">MHSRISAQVKQRRSGYEPSDTEAEWQDSPWNDADKKDEESNDAGPKILQDQTRNRSPFDRRNARRNDYDRSYPLRASAASPARRRHSKSPYAAPRDEGNTHSPVHHRKFPDSPFLKSELRRHVSPYKIALEDHQLDNGKIASSNRKFRQASDDVSKVNDTSTYSGRRAASVPKRTFKEKDLIKNESYWERSKPERTASPLRRNLSRKERDGSHKQAPSGGEINEMLANVKTAGAPTGMDPNFESTDSIGPGDIFFSRDYGAFTKQNSIFSTKNGTDIKFSEKPEFLIHTNPGFHKRNQANPWPNHNIREISATASNVSTQTTANSNFGVSRQSSNLSEFSGRTNGTIKNFLANRQKSQTDAWFSCIKRGSCRASEKSPEKPRGSYEALIIGKAFVVESLRQFWADKHRPSSLSEFTCHEHEALHLKQLATSEIPHILLKGPPGSGKKSLTMALLREIYGDTVRNISHDLHCFHIQETKPMEAIVPVSSSPHHVEFNVSSEPNVAYALMALVKKISTDYAVIREISNLTLIYVVYYSNDEVNILEHVKSRCKVINVEAPVTHEIIEVLIQIAGKEEFELPMSFAARIANKSKQNMRGAIMALEACKAQNYPFSEDQPIALGWEEVLVELAAGILADPSPKRISFIRGKFQKLLADFVHPKLILLKLVEQFLKGVDASSKREIYYWHSYYDKRLPTGTSALLKLEEFTAKFMSIQRRSLNHHQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1X7</accession>
    <name>A0A068U1X7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00039663001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="6"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP02307"/>
        <property type="gene ID" value="GSCOC_T00039663001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1X7"/>
    <dbReference type="OMA" id="GRIGECT"/>
    <dbReference type="OrthoDB" id="994442at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1X7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11444">
        <property type="entry name" value="bHLH_AtIBH1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044549">
        <property type="entry name" value="bHLH_AtIBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044660">
        <property type="entry name" value="IBH1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124">
        <property type="entry name" value="TRANSCRIPTION FACTOR IBH1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124:SF57">
        <property type="entry name" value="TRANSCRIPTION FACTOR UPBEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP02307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12398" checksum="9ED49EF75C4283B3" modified="2014-10-01" version="1">MGSRPRSYMGTPVLMRKTARRRPNPHRRACKIQHSSSTRIRAGACVSEKLEALKNLIPVHTDHGEIKPDQLFQETADYIVLLRTQISVLQNLVDVYGSSAGQAQPHRLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2Q5</accession>
    <name>A0A068U2Q5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00037069001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2Q5"/>
    <dbReference type="Gramene" id="CDP01893">
        <property type="protein sequence ID" value="CDP01893"/>
        <property type="gene ID" value="GSCOC_T00037069001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2Q5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="96" mass="11311" checksum="AF0377113AA40BAA" modified="2014-10-01" version="1">MSFCPFPGKERTYRHSQNKFELNLDESIPNSITEGSNSYCRLFHPKLQVPRSELTCSILRRSISTGTRHLRLGWNINYLTWKNEKLNKELKGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2U9</accession>
    <name>A0A068U2U9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00037124001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068U2U9"/>
    <dbReference type="FunCoup" id="A0A068U2U9">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2U9"/>
    <dbReference type="Gramene" id="CDP01938">
        <property type="protein sequence ID" value="CDP01938"/>
        <property type="gene ID" value="GSCOC_T00037124001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2U9"/>
    <dbReference type="OMA" id="RQEMYIG"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2U9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 84A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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    <dbReference type="InterPro" id="IPR017972">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47945">
        <property type="entry name" value="CYTOCHROME P450 84A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47945:SF5">
        <property type="entry name" value="CYTOCHROME P450 84A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP01938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="513" mass="57902" checksum="03880CCB3A999541" modified="2014-10-01" version="1">MDSLVQALDTETMLLLLIFPLAFLFLLSRFRSKPHPPGPRGLPLIGNMMMVNQLSHRGLAKLAHQYGGLCRLKMGFLNMVAVSSPEAARQVLQVQDNIFSNRPATIAISYLTYDRADMAFAHYGPFWRQMRKLCVMKLFSRRRAESWDSVRDEVDDMIKYAASNTGSAINLGELVFGLTRNIIYRAAFGSSCSEGQDEFIQILQEFSRLFGAFNLADFIPWLYWLDLQGLNKRLLKARASLDGFIDSIIDDHIEAKNKRNGLAVEGDSDMVDELLAFYSEEAKVSESEDLQNSIKLTRDHIKAIIMDVMFGGTETVASAIEWAMAELMKSPEDLKKVQQELKDVVGLHRKVEESDLDKLTYFKCCQKEVLRLHPPIPLLLHETAENAEVAGYQIPAKSRVLINAWAIGRDKDSWEDADKFKPSRFLKDGVPDYKGSNFEFIPFGSGRRSCPGMQLGLYALDMAVAHLLHCFTWELPDGMKPSELDMDDVFGLTAPRATRLVAVPTPRLLCPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2X5</accession>
    <name>A0A068U2X5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00040096001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="745247at2759"/>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045488">
        <property type="term" value="P:pectin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34208:SF5">
        <property type="entry name" value="OS01G0144000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34208">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP02642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19216" checksum="5F87E38261E9B33B" modified="2014-10-01" version="1">MRKVLHVGLDTCSVVSNLLKDDDTEAWGVEPYDLEDPSGSCKSLVHRGIVRVADIKFSLPYRENSFSLVIVSDAVDYLSPKYLNKTLSDLARVSSDGLVIFTGFPGHSRANVAELSKFGRPAKMRSSSWWGRFFVQTSLMENEAAVKKFEQVATESTYTPRCQVFHLKSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3E5</accession>
    <name>A0A068U3E5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00041214001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3E5"/>
    <dbReference type="STRING" id="49390.A0A068U3E5"/>
    <dbReference type="Gramene" id="CDP02827">
        <property type="protein sequence ID" value="CDP02827"/>
        <property type="gene ID" value="GSCOC_T00041214001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3E5"/>
    <dbReference type="OMA" id="PASVHFI"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3E5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050266">
        <property type="term" value="F:rosmarinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000015">
        <property type="entry name" value="Spermidine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000008">
        <property type="entry name" value="Tryptamine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF260">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP02827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="484" mass="53684" checksum="2465777188ABDC33" modified="2014-10-01" version="1">MYSQRQLQSLPGKEKPPSFTRHFCGHLSIAALPHHIPPRTKLISSCLISVGSEKMKITVKETAMVRPAQPTPTKRLWNSNLDLLVARIHILTVYFYKPNGSANFFDTRVLKEALSNVLVSFYPMAGRLARDEEGRIEIDCNGEGVLFVEAESDSSVDDFGDFAPSLELRRLIPTVDCSGDISSYPLVIFQVTRFKCGAAALGAGVQHNLSDGVSSLHFINTWSDIARGLTIAVPPFIDRTLIRARDPPVPVFEHVEYYPPPQLKSDSRIQELKTGPRASTTAVLKITPEQLSQLKAKANNEGSTYEILAAHIWRTACKARGLTNDQSTKLYVATDGRSRLIPPLPPGYLGNVVFTATPIAESSNLQSEPLTNSAKRIHNALARMDNDYLRSALDYLEIQPDLSALVRGPRHFASPNLNINSWTRLPFHDADFGWGRPIHIGPAIILYEGTVYVLPSPGKDRTLSLAVCLDADHMPLFQKFLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3S7</accession>
    <name>A0A068U3S7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00041654001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3S7"/>
    <dbReference type="FunCoup" id="A0A068U3S7">
        <property type="interactions" value="3418"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3S7"/>
    <dbReference type="Gramene" id="CDP03156">
        <property type="protein sequence ID" value="CDP03156"/>
        <property type="gene ID" value="GSCOC_T00041654001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3S7"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3S7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000011">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP03156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="187" mass="20583" checksum="E26D5E21886EC58D" modified="2014-10-01" version="1">MAEKPQPLHVVYCGVCGLPPEYCEFGPDFEKCKPWLIQNAPDLYPDLLKEAEAKEADKISGQLQSTSISDGSSASKPEEVKRLPGGKVKKKEKQEIIIEKVTRNKRKCITTVKGLELFGVKLSDASKKLGKKFATGASVVKGPTEKEQIDVQGDIAYDIVDFITETWPDVPEAAIYFIEDGKKVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4L3</accession>
    <name>A0A068U4L3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamin pyrophosphokinase thiamin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015901001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4L3"/>
    <dbReference type="STRING" id="49390.A0A068U4L3"/>
    <dbReference type="Gramene" id="CDP03505">
        <property type="protein sequence ID" value="CDP03505"/>
        <property type="gene ID" value="GSCOC_T00015901001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4L3"/>
    <dbReference type="OMA" id="GLESKWC"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4L3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="118" mass="13205" checksum="8E8ADC381304C58C" modified="2014-10-01" version="1">MCHGLRNCLRKGQRLPIIKISFSTKRIILLNDDCLIQLLPRSHHHEIHIKPSILGPHCGLVPMGMPSTNTTTTGLQWDLNNTEMEFGGLISTSNIGKGRIVTVHSDTDLIWTISIRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4L7</accession>
    <name>A0A068U4L7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Growth-regulating factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00041583001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription activator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GRF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4L7"/>
    <dbReference type="STRING" id="49390.A0A068U4L7"/>
    <dbReference type="Gramene" id="CDP03099">
        <property type="protein sequence ID" value="CDP03099"/>
        <property type="gene ID" value="GSCOC_T00041583001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4L7"/>
    <dbReference type="OMA" id="HQSQHFG"/>
    <dbReference type="OrthoDB" id="1927209at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4L7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031137">
        <property type="entry name" value="GRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014977">
        <property type="entry name" value="WRC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602:SF46">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08879">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51667">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="7">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="WRC" evidence="8">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP03099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="430" mass="48014" checksum="73FDC68AE87B4975" modified="2014-10-01" version="1">MMSATTSARSSSRFPFTASQWQELEHQALIFKYMVSGTPVPPDLLYTVRRSLDSSLSSKLLFHQPQLGWNSCFQMGFGRKIDPEPGRCRRTDGKKWRCSKEAYPDSKYCERHMHRGRNRSRKPVEQQLITTPIPPPPIISPPSFSNNNTSSTATPPTAIPITSISKNHPPSPSSPTSHHSFSCLTSLATSSESQPHHHHHNHNHNHGTGINQPGYSLHHPLLYPHSSCSRPPGTSHDRISSEENSANYLLGSGPYSQASKGYSYGQGGKEEVDEHAFFCEASGTVRNLSGGSSVVDHDGTSSWQLAPLTMGSPSGSHLKQRSSYSVSNGGHSSYLQLQSLNHDSDYNTTSRQQKQASQQQYYGLGDRDDHQNKRVMHRFFDEWPPKDNKDSCWLDNNDHHDHKLSKIQLSISMPNASSHHDFFMTRNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U588</accession>
    <name>A0A068U588_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00015279001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U588"/>
    <dbReference type="Gramene" id="CDP03482">
        <property type="protein sequence ID" value="CDP03482"/>
        <property type="gene ID" value="GSCOC_T00015279001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U588"/>
    <dbReference type="OMA" id="DCKARIF"/>
    <dbReference type="OrthoDB" id="1900964at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U588"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000373">
        <property type="term" value="P:Group II intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044190">
        <property type="entry name" value="THA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47594:SF5">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47594">
        <property type="entry name" value="PPR CONTAINING PLANT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP03482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22615" checksum="EE1F569872443CD9" modified="2014-10-01" version="1">MWRSRVLSREAIQAVQSLKLAKCPDKLAEVFANRISRLMKADLLDILSELQRQNEVELALQVNVYISGQVWYEPDISIFSDMILMLGKSSNIEIAERLFGEIEKEVLWPDTRTYTAVIGAYFRVKMIEKAMESYESMKGSGCVPDKLTFRILIKNLEKAGEKELIATVKKDCLSYIEYPEKFLEEVEKTYVSTVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5P4</accession>
    <name>A0A068U5P4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="1">ETF-QO</shortName>
            <ecNumber evidence="1">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015316001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5P4"/>
    <dbReference type="STRING" id="49390.A0A068U5P4"/>
    <dbReference type="Gramene" id="CDP03499">
        <property type="protein sequence ID" value="CDP03499"/>
        <property type="gene ID" value="GSCOC_T00015316001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5P4"/>
    <dbReference type="OMA" id="HNDPRWE"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5P4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="175" mass="18998" checksum="10E7CC73735E2BE4" modified="2014-10-01" version="1">MNYDVVIVGAGPAGLSAAIRFKQLCHEKNVDLSVCVVEKGAQVGAHILSGNVFEPRALDELLPQWKQEDAPIHVPVTSDKFLLLTKNHALPLPSPFNNKGNYVISLSELVRWLGVKAEELGVEIYPGFAASEVLYDVDDKVIGVATNDMGVAKDGTRKDIFQPGVELKGMFTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5Y8</accession>
    <name>A0A068U5Y8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00016493001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium sensor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5Y8"/>
    <dbReference type="FunCoup" id="A0A068U5Y8">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U5Y8"/>
    <dbReference type="Gramene" id="CDP03975">
        <property type="protein sequence ID" value="CDP03975"/>
        <property type="gene ID" value="GSCOC_T00016493001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5Y8"/>
    <dbReference type="OMA" id="EELCEWI"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5Y8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000089">
        <property type="entry name" value="calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000231">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP03975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="150" mass="17235" checksum="9A2BAB168594E257" modified="2014-10-01" version="1">MDPGELRRVFQMFDRNGDGKITKKELNDSLQNLGIYIPEKDLIQMIDKIDVNRDGYVDIDEFGSLYQTIMDERDEEEDMREAFNVFDQNGDGFITVEELRSVLSSLGLKQGRTLEDCKLMIKKVDVDGDGMVNYREFRQMMKGGGFAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6U9</accession>
    <name>A0A068U6U9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">cv. DH200-94</strain>
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        <property type="component" value="Chromosome I"/>
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        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="24051" checksum="30143F72CC1B7D8D" modified="2014-10-01" version="1">MNAEVISSGHLQLFPTSSNTRHCGSQLPFSGRASTGSIALKPRRRPGPLRITARAAVYAPTQTQAETFYDMLGISETGSISDIKKAYKQLARKYHPDVSPADRTEEYTKRFIEVQEAYETLSDPQTRALYDMNLGRGLHFAFSTGRRNERMDDVEEWKLRWQSQLDELRLWSMHRDNVSSAVRGKAAASPSSSWGSRMRRKRTDIYDLGFR</sequence>
</entry>
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    <accession>A0A068UA60</accession>
    <name>A0A068UA60_COFCA</name>
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        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020377001</name>
    </gene>
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        <lineage>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
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                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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            <end position="373"/>
        </location>
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        <source>
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        </source>
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        <source>
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    <sequence length="619" mass="68326" checksum="5A626ED3F62B8E7D" modified="2014-10-01" version="1">MERNENCLVVGDNNPMESANSKAGISVFSSSLFLDSVGEVVLTLNPSSDQLYWQSVDPLDHGRSCCGLFSNSDSALKISDVYAVEFIDYGIVHESALTNAAGGCLSGHPTEMYRFKVYGVQKSKTYPSIWAPSIYTFGHSDSRTCRMWVNRINASLDMEADRPKNLLVFVHPRSGKGNGCRTWDAVAPIFSQANVKTKVIMTERAGHAFDVLASITNRELDSYDGVVAVGGDGLFNEILNGLLLSRHEVPCPSRSMDFKNYVDNGCELSVHEAVGNLEEPSDPCEDDSPLLMNIGHSRTQVSNLRSEADLCHTEHDSKFSFPHERFRFGIIPAGSTDATVICTTGGRDPVMSALQIVLGKRLCLDVAQVVRWKTTSTSKDEPYVRYAANFAGYGFYGDVIMESEKYRWMGPKRYDYAGTKVFLQHRSYEAEVAYVQVESEKASVRPERGPWSRKMKALMGLSDPSTKGTCRANCSVCNEKPIQSSAKSASIGPYKGESKWKKSKGRFLSVGAAVISCRNERAPDGLVADAHLSDGFLHLILVKDCPRALYLRHLTQIAMKGGNPLNFRFVEHHKTTAFMFTSFGKESVWNVDGEILQGHQLSAQVYRGLVSLFATGPEV</sequence>
</entry>
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    <accession>A0A068UAW9</accession>
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        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAW9"/>
    <dbReference type="FunCoup" id="A0A068UAW9">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UAW9"/>
    <dbReference type="Gramene" id="CDP05344">
        <property type="protein sequence ID" value="CDP05344"/>
        <property type="gene ID" value="GSCOC_T00020349001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAW9"/>
    <dbReference type="OMA" id="FSDHRMD"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UAW9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22159">
        <property type="entry name" value="F-box_AtTIR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001445">
        <property type="entry name" value="F-box protein At5g51380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF124">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="491" mass="54985" checksum="32F1464EE95F7FE3" modified="2014-10-01" version="1">MSCSPEKPNGNSPLKLWIKNKKVLNNVLFTMRLQTLTKQPQTPSLMTPRPHKTEGFTFPELVSDKTSLLPDEILLQILSKLPDSQRNSNSLVSKRWLNLQGRLVKSVKLLDWNFLVSSRLFVRFPNLVHVDLVEGSLTSARNSGILCTHKVASFYVDTDTEPKGSLACERFLLHADEIDLGLRNLANGCPNLRRLVVLNASEMGLLSVAEECPTLQELELHRCSDQVLRGIAAFQNLQILRLIADIDGFYSSVVSDVGLTILAQGCKRLVKLELNGCQGSYDGIRAIGQCCQMLEELTFCDHKMEDGWLAALSYCENLKTLRFLSCKTIDLNPGPHEHLGSCPTLERLHFEKCQLRDKQSVRALFVVCQGVKDIIFKNCWGLNNDIFSITTDLRSVKLLSLEGCPVLTTAGLELVVISWMEIQSLRVISCNKIKDTEISPVLSYLFSTLKDLQWRPDTKSLLSANLVGSRMGKRGAKFFKKTCDWKALTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCR7</accession>
    <name>A0A068UCR7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00021418001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCR7"/>
    <dbReference type="FunCoup" id="A0A068UCR7">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCR7"/>
    <dbReference type="Gramene" id="CDP06062">
        <property type="protein sequence ID" value="CDP06062"/>
        <property type="gene ID" value="GSCOC_T00021418001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCR7"/>
    <dbReference type="OMA" id="NWVQPKW"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCR7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP06062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="410" mass="42859" checksum="2B2B175A9F5C5266" modified="2014-10-01" version="1">MQSSLFMIHGTARTCYPNCSRIGGIAGSPTSRKNTSLNFSNFKLAKSQENYQFTKPVSLVPAKPKRSLLCGNSSNGTVSVDDGGSSGIASNASSGRSWIEAVGDAISTAFPLWVAIGCLLGLLKPSSYNWVQPKWTIMGITLTMLGMGMTLTFDDLRGALAMPKELFSGFVLQYSIMPLSGFFVSKLLNLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVVMTPALTAKLAGQYVAVDAPGLFMSTLQVVLLPVLAGAFLNQYFQSIVKIVSPLMPPIAVLTVAVLCGNAIAQSSSTILMSGQQVVLATVLLHASGFLFGYVLSRMLGLDVSSSRTISIEVGMQNSVLGVVLATQHFGNPLTAVPCAVSSVCHSIFGSALAGIWRQSVPAQVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDI3</accession>
    <name>A0A068UDI3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00023120001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDI3"/>
    <dbReference type="FunCoup" id="A0A068UDI3">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDI3"/>
    <dbReference type="Gramene" id="CDP06332">
        <property type="protein sequence ID" value="CDP06332"/>
        <property type="gene ID" value="GSCOC_T00023120001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDI3"/>
    <dbReference type="OMA" id="PRKMEHT"/>
    <dbReference type="OrthoDB" id="1884766at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDI3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053192">
        <property type="entry name" value="Vacuole_Formation_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410">
        <property type="entry name" value="CYSTEINE/HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410:SF216">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP06332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="370" mass="42783" checksum="F59CA9AE220DAF41" modified="2014-10-01" version="1">MISQSTKQKNEDDKYSISEGELDLEDQCATKKNVVKLPSSHAAQELISHLLNKADESSSSSGELKAEEKIFIEEHQHPVILSKREQIQDENNGTKEEAITLVCEWCIEPISSSDLHYSCVECGYYVHFTCYKLPSELQITKHPEHPLLLRYEANAVGHFVCNACQRQSNGEFYECDRDSCELRFCIKCASASMIPNVVHAAHKHLLTQYGSSDPTKCNACGTKSDGFVFACKYCHFYLDYECALLPPATKQRWDKHPLILVYPPYFDHPEEFYCVLCEEEINPNTWMYHCRDCDYSLHPWCIPQFKLFRDLKFGRSLLVDDHPHHLTHVPEARYKSFCEACKDSLDWKESFECNSCSYYLCPDCAFEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDI8</accession>
    <name>A0A068UDI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00023137001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a key role in the control of the eukaryotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDI8"/>
    <dbReference type="FunCoup" id="A0A068UDI8">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UDI8"/>
    <dbReference type="Gramene" id="CDP06337">
        <property type="protein sequence ID" value="CDP06337"/>
        <property type="gene ID" value="GSCOC_T00023137001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDI8"/>
    <dbReference type="OMA" id="QWNSGEE"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000281">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase B2,2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="312" mass="35310" checksum="06FDE5E0F858254E" modified="2014-10-01" version="1">MEKYEKLEKVGEGTYGKVYKAKDKTTGQLVALKKTRLEMDEEGVPPTALREVSLLQMLSQSLYVVRLLCVEHIVDGNKKNGGSGNGKPLLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPSLIQSFLFQLCKGIAHCHSHGVLHRDLKPQNLLVDKDKGILKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTAVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEKHWPGVCSLRDWHVYPQWEAQNLSRAVPSLEPDGVDLLSKMLKYDPAERISAKAALEHPFFDSLDKSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE05</accession>
    <name>A0A068UE05_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023391001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE05"/>
    <dbReference type="FunCoup" id="A0A068UE05">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UE05"/>
    <dbReference type="Gramene" id="CDP06512">
        <property type="protein sequence ID" value="CDP06512"/>
        <property type="gene ID" value="GSCOC_T00023391001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE05"/>
    <dbReference type="OMA" id="HALFHTR"/>
    <dbReference type="OrthoDB" id="515004at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE05"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35731">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35731:SF1">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="256" mass="29090" checksum="8DF0C327E4532AEC" modified="2014-10-01" version="1">MMSLKAFQSPCTPNKHALLRGRDYSKRKYTNLLLCKANESDSGIPPPEGDRRKQELLARIAMLQAQKLRLTDYLDERSAYLTQFAEEANAEIDQIGENALKELDEAGSRIMENIESQMQAFEESAELNKQEIEEGDRKLADFEGQIEEDRNEGLFFKNLRQKTPPGNERAEEQRMKLRELAKENAGSKTRRNIYLALIGLVLIGICDASITSSSDWRKVAVLGAILVGLLSQLLYEQMMLSETEKTEQNKSKVDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UE54</accession>
    <name>A0A068UE54_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar cation/proton exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00023358001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UE54"/>
    <dbReference type="FunCoup" id="A0A068UE54">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UE54"/>
    <dbReference type="Gramene" id="CDP06489">
        <property type="protein sequence ID" value="CDP06489"/>
        <property type="gene ID" value="GSCOC_T00023358001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UE54"/>
    <dbReference type="OMA" id="MATTEPW"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UE54"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061993">
        <property type="term" value="C:calcium:proton antiporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010351">
        <property type="term" value="P:lithium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010119">
        <property type="term" value="P:regulation of stomatal movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000008">
        <property type="entry name" value="Vacuolar cation/proton exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000020">
        <property type="entry name" value="Vacuolar cation/proton exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF97">
        <property type="entry name" value="VACUOLAR CATION_PROTON EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="8 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="251"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="422" mass="45579" checksum="CC1E72ABC9EEF38D" modified="2014-10-01" version="1">MSSSSLRKKSEIALVSKVPYRFVRDFLANLQEVILGTKLSVLFLAIPFAIAAQCNHFGRPWVFALSLLGLTPLAERVSFLTEQIAMYTGPTVGGLLNATCGNATELIIAILALVQHKVDVVKYSLLGSVLSNLLLVLGTSLFCGGLANVSKEQKFDRKQSDVNSMLLLLGLLCHLLPLMLKYSRNSADVFALETTVVSLSRVSCILMLIAYLAYLVFQLWTHRQFFEAQEDEDEYGDGIAEETPVIGFWSGFAWLAGMTGVIALLSEYVVATIEAASDTWGLSVSFISLILLPIVGNAAEHAGAIIFAFKNKLDISLGVALGSASQISMFVVPLTVIVAWIIGINMDLDFNLLETGSLALSIIITAFALQDGTSHYMKGLVLLLCYVVIGACFFVSRSPLNQGPANVVDLGMKSSAHGILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UF27</accession>
    <name>A0A068UF27_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00023930001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UF27"/>
    <dbReference type="Gramene" id="CDP06892">
        <property type="protein sequence ID" value="CDP06892"/>
        <property type="gene ID" value="GSCOC_T00023930001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UF27"/>
    <dbReference type="OMA" id="KYPANED"/>
    <dbReference type="OrthoDB" id="1546383at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UF27"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 7 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019616243" description="Germin-like protein" evidence="9">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="10">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="212" mass="22821" checksum="338FF0ECAEDDBA0F" modified="2014-10-01" version="1">MALRPSTNLFLTLMLNLLAIFSPMAMASDADILTDFNLPPNVSNVDATFFTYTAARSLVGAQPPTALNFLFADKTSFPALDGQSVSLAVLRMPGGAVNPPHSHPRATELLLLISGYLEVGFIDSTNKLFNQTLNAGDMYVFPKGLVHYQFNYAPDVPAIAVSAFGSANPGLVSIPSNLFQTDIEDRILAWSFKTDIPTIQRIKASVQGSPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UF61</accession>
    <name>A0A068UF61_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00023845001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UF61"/>
    <dbReference type="Gramene" id="CDP06834">
        <property type="protein sequence ID" value="CDP06834"/>
        <property type="gene ID" value="GSCOC_T00023845001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UF61"/>
    <dbReference type="OMA" id="KMGWNLK"/>
    <dbReference type="OrthoDB" id="1910371at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UF61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000001">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.30:FF:000003">
        <property type="entry name" value="Os04g0303100 protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF118">
        <property type="entry name" value="OS09G0551150 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657914" description="non-specific serine/threonine protein kinase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1341"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="15">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="16">
        <location>
            <begin position="342"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="496"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="15">
        <location>
            <begin position="914"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="16">
        <location>
            <begin position="1229"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1398"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP06834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1716" mass="194386" checksum="5C9ECE14202ED3F4" modified="2014-10-01" version="1">MQMESISNSMFSYVLISFLLIRSCNGTDRISQNQTMADGETLVSSGGTFVLGFFKPPSSTNRYLGIWYNRSPETIVWVANKVSPLTDSDGVLTIHSDGNLVLLNGTKRIIWSSNSSSADAPMNLVAELLDSGNLVLKRQDDFKAESYVWQSFDFTTDTLLPGMKEGKNLQTGQTWYLTSWKNQNDPSAGEFSYKLDTIGLPQFVLRKGSEKKFRTGLWNGQRFSGSAVRSSMFNAPAFVYNDTDIYYTYEMRDSSELSRVTLDESGVIEHYMMNKGSSDWKLMYKLPYDMCGEYGNCGPNSICKTNSDPICQCLDGFVPKLKGDWDALNWSGGCMRRTPLDCKPGEDFIRLGNVKLPDLLDFWLDQSMTIRECKRECLKNCSCTAFTNSNITNGGSGCLMWFGDLIDIQEYDDNIEQDIYLRMPRSELDAIQNQKKKRALLILVVPIVSGGMLVLYFVIWCTIRRRKEKRGMKTGNDDIELPLYQLEAVTMATKSFSFSTIIGEGGFGPVYKGRLATGVEIAVKRLSQTSRQGLGEFKNEVILISRLQHRNLVRLLGCCLDGNERMLIYEYMTNGSLDYFIFDQSRKKLLTWKKRFEIALGISRGLLYLHQDSRLRIIHRDLKASNILLDNELNPKISDFGIAKSFRGDQTEGKTRTVIGTFGYMSPEYAFSGTYSVKSDVFSLGVLLLELVSGRRNRTLDHSDQHQSLLGHYWNHRHSPYQNPLTKQPLYHLSTFLTHYKYFFPQSYNNFVLDSADVFPQPASNWLTIDILNHGLARAWLLWTEDKALQLMDECLKESSVESQVLRCIQVALLCVQKHPEDRPTMAAIVIMLSNETVSLPQPKHPGFFLEGNYARVSETSTEERLRTLNAVFSIETGKNVPNRTLNHLKLSISNSMFSYVLISFLLIRSCNGTDGISQNQTMADGETLVSSGGTFVLGFFKPPGSTNRYLGIWYKRSPETIVWVANKVSPLTDSDGVLTIHSDGNLVLLNGTKRIIWSSNSSSADAPMNLVAELLDSGNLVLKRQDDLKAESYVWQSFDFLTDTLLPGMRKGINLRTGKTWYLTSWRNQSDASPGEFTYKLDNVGLPQYVLRKGSEKKFRTGPWNGERFSGSPVRSSSFIAPIFVYNDTEIYYTYEMTDSSVLSRVTLDESGVIEHYMMNKGSSDWILMYKLPYDMCEEYGKCGPNGICRINSNPICQCLDGFVPKSKGDWDVLIWSGGCKRRTPLDCKSGEGFIKLKNVKLPDLLDFRLSQSMTTRECERECLKDCSCIAFTDSNITNGGSGCLMWFRDLIDIQEYDDKYSEQDIYLRMPKSELALWMQPVTVNFLNADAIENQNKKRALLILVIPTVFGGILVLCFVLCCMIRRRKKKRGMKTSNDDIELPLYQLEAVTLATKSFSFSNIIGEGGFGPVYKGRLETGVEIAVKRLSQTSRQGLGEFKNEVILISKLQHRNLVRLLGCCLDGNERMLIYEYMTNRSLDYFIFDQSRKKLLTWKNRFEIALGISRGLLYLHQDSRLRIIHRDLKASNVLLDNELNPKISDFGIAKIFRGDQTEGKTRTVIGTYGYMSPEYAFSGTYSVKSDVFSLGVLLLELVSGRRNRTLDHSDQHQSLLGHAWLLWTEDKALQLMDECLKESSVESQVLRCIQVALLCVQKHPEDRPTMAAVVIMLGNETVSLPQPKHPGFFLEGNYAGVSETSTEERLRTENAVTITQMEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFI4</accession>
    <name>A0A068UFI4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAB6-interacting golgin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00024027001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GORAB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFI4"/>
    <dbReference type="STRING" id="49390.A0A068UFI4"/>
    <dbReference type="Gramene" id="CDP06964">
        <property type="protein sequence ID" value="CDP06964"/>
        <property type="gene ID" value="GSCOC_T00024027001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFI4"/>
    <dbReference type="OMA" id="SCNGSPT"/>
    <dbReference type="OrthoDB" id="1921288at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFI4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007033">
        <property type="entry name" value="GORAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470:SF2">
        <property type="entry name" value="RAB6-INTERACTING GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470">
        <property type="entry name" value="RAB6-INTERACTING PROTEIN GORAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04949">
        <property type="entry name" value="Transcrip_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP06964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="20256" checksum="61B12F51DFB8D4F0" modified="2014-10-01" version="1">MSTQIPVLEQQQQQSQMMRLKTSGVLNYSGSPLNDDKEEEMTKSALSAFRAKEEEIERKKAEVRERVQAQLGRVEEETKKLAEIREELEALADPMRKEVALIRKKVDLLNRELKPLGQTCQRKEKEYKECLDAFNEKSREKTQLVSKLMELVSESEKLRMKKLEELSKSINSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFR0</accession>
    <name>A0A068UFR0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023331001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFR0"/>
    <dbReference type="STRING" id="49390.A0A068UFR0"/>
    <dbReference type="Gramene" id="CDP06468">
        <property type="protein sequence ID" value="CDP06468"/>
        <property type="gene ID" value="GSCOC_T00023331001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFR0"/>
    <dbReference type="OMA" id="MSHINVF"/>
    <dbReference type="OrthoDB" id="781635at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFR0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051886">
        <property type="entry name" value="Seed_Dev/Stress_Resp_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46354">
        <property type="entry name" value="DOG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46354:SF13">
        <property type="entry name" value="PROTEIN DOG1-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOG1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="249" mass="28119" checksum="26C0BDF2FC748E12" modified="2014-10-01" version="1">MMASSSRQPIGGAGSFQAFFEDWLVRQQRFLDELLSAQESSSTTSRIDDTDVVGDLIARVLAHYQEYYDEKSRMAHRNVFLAFSPTWFTPLERTFLWIAGFKPGLVCRLALGSLDDLTEDQIHRINGLSRETNWQEKLLDQKMAKIQESVASPPLVDLARSEGMQIQSATGSDIDDVDNQIEPLKSAMQNILRDADGLRTRTAETMAGILSPLQNVRFLSAAARLQFRIRMLGFQREADRQRGSTTNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGD8</accession>
    <name>A0A068UGD8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00024946001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGD8"/>
    <dbReference type="FunCoup" id="A0A068UGD8">
        <property type="interactions" value="1146"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UGD8"/>
    <dbReference type="Gramene" id="CDP07630">
        <property type="protein sequence ID" value="CDP07630"/>
        <property type="gene ID" value="GSCOC_T00024946001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGD8"/>
    <dbReference type="OMA" id="QCLRYNP"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044251">
        <property type="entry name" value="LHP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47240">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN LHP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47240:SF2">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN LHP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="424" mass="46171" checksum="6E76361E260C6A99" modified="2014-10-01" version="1">MGNDQNPPRGPPSSLDAPADDGRQKQPEKGAGAGGAEKDSSVAAVAAAEAEEEEEEEEEEEGEKANDQFDEGQMEEGEGEEGEGEGEKAKLAEGYYEIEAVRRKRVRKGEVQYLIKWRGWPETANTWEPLENLLSCSDVIEAFEDSLRSGKRSTRRRKRKYGSAQSQSKKKQQQRSPAAATYNVPAVKVRILEKPLPFPPLNEPGSTNGEAGVNGVDNENGVNPATFRTDLLEEPNELNLKISELRGAAVNNEDCVDKYTIDAQEAPLSEQSGRANGLQNADCPEPVQSGRCTGAKRRKSGSVKRFKQDSPSGMAENLQNMAATNGSCGMSANSGSQSSDHMANDLRFKSKVDSSKHICDITEIVKPVSYLSAAANSNGQDISVTFMAKRSDGSEVTVDNKFLKANHPVLLINFYEKHLRYSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGV9</accession>
    <name>A0A068UGV9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00024791001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGV9"/>
    <dbReference type="STRING" id="49390.A0A068UGV9"/>
    <dbReference type="Gramene" id="CDP07512">
        <property type="protein sequence ID" value="CDP07512"/>
        <property type="gene ID" value="GSCOC_T00024791001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGV9"/>
    <dbReference type="PhylomeDB" id="A0A068UGV9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF354">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE IRE4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP07512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="136" mass="15218" checksum="D5F4B1F72A7E2F5B" modified="2014-10-01" version="1">MEVLQDEQAITGLHELSAGFPADWRSIGIILFELLIGFPPFTTELPEALPIFLSLLNKKRELLNYMLMSNQSCRFLDHGPDLRLGAKGASEVKAHPLFTAADWDNLALQKVSSGNIFFALVPLCVEFSCLEWLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UH27</accession>
    <name>A0A068UH27_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025347001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UH27"/>
    <dbReference type="Gramene" id="CDP07870">
        <property type="protein sequence ID" value="CDP07870"/>
        <property type="gene ID" value="GSCOC_T00025347001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UH27"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="55" mass="6113" checksum="8FAF4644497EC5DD" modified="2014-10-01" version="1" fragment="single">ASSLLIPFGCFFSRQNRACKVAISAVLLLLYARFYRGTACFSLILPRSFFCSQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHC5</accession>
    <name>A0A068UHC5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">signal peptidase I</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00024911001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHC5"/>
    <dbReference type="STRING" id="49390.A0A068UHC5"/>
    <dbReference type="Gramene" id="CDP07604">
        <property type="protein sequence ID" value="CDP07604"/>
        <property type="gene ID" value="GSCOC_T00024911001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHC5"/>
    <dbReference type="OMA" id="YGMEPMS"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000012">
        <property type="entry name" value="Peptidase/ serine-type peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="SIGNAL PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390:SF2">
        <property type="entry name" value="THYLAKOIDAL PROCESSING PEPTIDASE 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase S26" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP07604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="152" mass="16922" checksum="C095114D33396EBF" modified="2014-10-01" version="1">MYPTLDVGDRILAEKVSYVFRKPEVSDIVIFKAPPILQEIGYSSGDVFIKRVVAKAGDYVEVRDGKLLVNGVAQDEDFILEPVAYEMDPVLVPEGYVFVMGDNRNNSFDSHNWGPLPIQNIVGRSVFRYWPPSKVSDTLCDSSLTTTAVAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJH6</accession>
    <name>A0A068UJH6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00025126001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJH6"/>
    <dbReference type="STRING" id="49390.A0A068UJH6"/>
    <dbReference type="Gramene" id="CDP07758">
        <property type="protein sequence ID" value="CDP07758"/>
        <property type="gene ID" value="GSCOC_T00025126001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJH6"/>
    <dbReference type="OrthoDB" id="1743610at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="21168" checksum="3833DC8F2A38F364" modified="2014-10-01" version="1">MGFMCPWTFSCPSYSVRLHCWIFQQLTFVFGVFWLSSTPDDKCCTWKGLSILFLCLWCKWANHLLTAILELMCSFCLGVTFGTGPFCFFFWFCIRVFNSTFRSSVLVLSLVYGCISSVFLACLYLVMGLYLTNWLMDCPLLQHAYRDGRLEEVVLRHLGAEDGQTVIAKNIRLSDFLSNFQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJQ1</accession>
    <name>A0A068UJQ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027371001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJQ1"/>
    <dbReference type="STRING" id="49390.A0A068UJQ1"/>
    <dbReference type="Gramene" id="CDP08464">
        <property type="protein sequence ID" value="CDP08464"/>
        <property type="gene ID" value="GSCOC_T00027371001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJQ1"/>
    <dbReference type="OMA" id="MCPGIHF"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJQ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052306">
        <property type="entry name" value="CYP450_71D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953:SF16">
        <property type="entry name" value="CYTOCHROME P450 71D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47953">
        <property type="entry name" value="OS08G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47612" checksum="96DBC57CE412E6DD" modified="2014-10-01" version="1">MHHLIGSLPHRRLKNLAQKHGPLIHLQLGEVSAVVVSSPNLAKEIMKTRDLSFASRPELLTFKIVCYDSKDILFSPYGDYWRQMRKICVTELLSAKSVMSFHNIRQDEVLHLVAAIGQLAGKSVNITEKLFSHTSSMVCRAAFGQVSKEDQYEFVRLMKQEHVKNQTRKKKFIADSNQEDLIDVLLRIRDSEDLQFPITNDNIKAIIFDMFAGGTETSSSTVEWAMSEMIRTPMVMAKAQEEIRQAFKGKQKIDEIDVQELRYLKFVIKETLRLHPPAPLLIPRECREQCEVNGYTIPIKTKVVVNCWALGRDPEYWSDPESFEPERFDNNPVDFTGNHFEFVPFGGGRRICPGMSFGLVNMELQLALLLYHFNWRLPDGMNSEDLDMIENNGITATRKNNLYLVPSLYDPSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKC4</accession>
    <name>A0A068UKC4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00028157001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKC4"/>
    <dbReference type="FunCoup" id="A0A068UKC4">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKC4"/>
    <dbReference type="Gramene" id="CDP08995">
        <property type="protein sequence ID" value="CDP08995"/>
        <property type="gene ID" value="GSCOC_T00028157001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKC4"/>
    <dbReference type="OMA" id="SEWWLMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKC4"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF35">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="218" mass="25137" checksum="147776D4849CDE6E" modified="2014-10-01" version="1">MSRPFKLYLLSYNSLLALGWTLSLFKILSNFSLTKSVSGTYASAGELICFLQTIAFLEVIHGAIGIVPSGVLFPLMQWGGRTHFLLAVVRGINEVQKLPSVFITFVAWSLSEVIRYLHYAINSTGNPPYWITYLRYTAFIVLYPIGVAPGEMWLMYQALPFIKAKNLYADFFAFLPFSYYTFVVILLIFYPFLWLKLYLHLFKQRSSKLLNQHKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL48</accession>
    <name>A0A068UL48_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028475001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL48"/>
    <dbReference type="FunCoup" id="A0A068UL48">
        <property type="interactions" value="2612"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UL48"/>
    <dbReference type="Gramene" id="CDP09235">
        <property type="protein sequence ID" value="CDP09235"/>
        <property type="gene ID" value="GSCOC_T00028475001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL48"/>
    <dbReference type="OMA" id="KYAKHRR"/>
    <dbReference type="OrthoDB" id="17346at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL48"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="7">
        <location>
            <begin position="597"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="982" mass="110783" checksum="8619FA3751E19C7F" modified="2014-10-01" version="1">MASTSNSQSSIQDDDDQEEEALLSVFLYLFLSYHKTKRDIYFSLVKFLQIEHFDDFTLASSWERFISEIEAVCRQWLATGPKNLVKKDAVCLDFSKNIYKVRSELKYAMKNYSMEYYFEPFNDGKVADWISTSHDLQQSFGVKDFLVIAPQSASGVVLDAPEASKLLSAVSIAMSNSSSLWPAFVPVHDPSRRAYIGIQNMGTIFTRRFEADRIGSQVPIKLMHLEGLYELFVSKFAYSTVDLSMHLFKVHFRMKLTYRTLPTDDDPEVQQESEFLESGGHSEFETHNKIQWDDDCPWSEWYSAEDPVKGLELLAIWSERTVDSSLDMAELENASPLEADKWFIFPNLSPHLESSDGSTIGFASQLRLLVNALDSSLGAQFMEDFVSVENSGSDNMKSSAVIPPPTVLDRVLKDLFHEDAEVKLDFADAENKNSRAIKGAPLESPFAQFCLHALWFGNCNIRAIAVLWIEFVREIRWCWEESQPLPRMPTNGTVDLSTCLIYQKLHMLAICIEKKHQENKEHPDVGDKKTSPYIEGKAQITKQSSSLLEVTEDSSGERDSLTARNDLGSHGVATSLSNSEQQNFASPTDTKLSEYIRMGSAGVVGSTMLLNSCQQMHAPFTQDPPLMTEDMHEERLKAVEAFGDSFSFSAQLEKEILSSDMSAFKAANPDAVFEDFIRWHSPRDWENDDNGELAVSQAKAGEVSKNEWPPRGRLSERMSDHGSSWRKIWNEAPSLPAFKQKPLLDPNREGEKVLHYLETMRPHQLLEQMVCTAFRAAADTLNRTAFGGLKLMTSKLGQLCLTMASTLKSLQRNSLSVDSEIIEDLTRLCVIFEHVEKLLTVAASLHRKFLQAPRLSEAIFSDFYNFYLPKMGTGSGSHDIDKSQEFTKKQQIMAREKEVVASMFTPPTANQSWRKVLSLGNLLNGHEPILREIIFSKRDHVSGGYYAGSYAGGYPQEIETYRMYLCGTSNDLRVALAVASCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULC9</accession>
    <name>A0A068ULC9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ALOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00028476001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant homeotic and developmental regulators ALOG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULC9"/>
    <dbReference type="FunCoup" id="A0A068ULC9">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULC9"/>
    <dbReference type="Gramene" id="CDP09236">
        <property type="protein sequence ID" value="CDP09236"/>
        <property type="gene ID" value="GSCOC_T00028476001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULC9"/>
    <dbReference type="OMA" id="EPATWSC"/>
    <dbReference type="OrthoDB" id="1906822at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULC9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040222">
        <property type="entry name" value="ALOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006936">
        <property type="entry name" value="ALOG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31165">
        <property type="entry name" value="PROTEIN G1-LIKE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31165:SF59">
        <property type="entry name" value="PROTEIN LIGHT-DEPENDENT SHORT HYPOCOTYLS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04852">
        <property type="entry name" value="ALOG_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51697">
        <property type="entry name" value="ALOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ALOG" evidence="9">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="224" mass="22810" checksum="526A8E15CA2F09F8" modified="2014-10-01" version="1">MDSASGGPDLSGGGEAGPSSASGSGSAEGVGGSTAAPPSRYESQKRRDWNTFLQYLRNHKPPLTLARCSGAHVIEFLKYLDQFGKTKVHVAGCPYFGHPNPPAPCQCPLKQAWGSLDALIGRLRAAYEENGGRPESNPFGARAVRIYLREVRESQAKARGIPYEKKKRKRPAATAVPAVSVAASDVGASCSGGGDVGGGGGGDGGSGGGPGGTPTTVVVTTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULY6</accession>
    <name>A0A068ULY6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00028596001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULY6"/>
    <dbReference type="STRING" id="49390.A0A068ULY6"/>
    <dbReference type="Gramene" id="CDP09297">
        <property type="protein sequence ID" value="CDP09297"/>
        <property type="gene ID" value="GSCOC_T00028596001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULY6"/>
    <dbReference type="OMA" id="YYEIHLL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULY6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000075">
        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP09297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="159" mass="17954" checksum="B43E6D3E7933C14C" modified="2014-10-01" version="1">MCPSMSKSKKQENKGGVLEISPDGRFIKYDEVLGRGAFKTVFKGFDQENGTEVAWYQINLEAGRAAASLDDLPKLAKSLLTEAALMKSLKHNNIIRCQHSWVDEDNMNVNMITELFSSGTLREFSKNHKCVNIKAIKNWAKQILEGLNYLHTRNPPIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UM89</accession>
    <name>A0A068UM89_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00027748001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UM89"/>
    <dbReference type="STRING" id="49390.A0A068UM89"/>
    <dbReference type="Gramene" id="CDP08693">
        <property type="protein sequence ID" value="CDP08693"/>
        <property type="gene ID" value="GSCOC_T00027748001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UM89"/>
    <dbReference type="PhylomeDB" id="A0A068UM89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP08693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="85" mass="9420" checksum="88835CFDF03D5E4D" modified="2014-10-01" version="1">MADSVGPQQQQVCIFFKKPSKGKNIRKCPAFQEDNGDDDSVGESSVIYKKKPAAANNKLHFSIGSSKRSIEIETIVDSRTPFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UME6</accession>
    <name>A0A068UME6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="12">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00028782001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="12"/>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UME6"/>
    <dbReference type="FunCoup" id="A0A068UME6">
        <property type="interactions" value="1248"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UME6"/>
    <dbReference type="Gramene" id="CDP09424">
        <property type="protein sequence ID" value="CDP09424"/>
        <property type="gene ID" value="GSCOC_T00028782001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UME6"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UME6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP09424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="148" mass="16343" checksum="5BDE4490B8AD1F99" modified="2014-10-01" version="1">MEQTFIMIKPDGVQRGLVGEIIGRFEKKGFTLKGLKLITVDRPFAEKHYADLSAKPFFNGLVEYIISGPVVAMVWEGKNVVTTGRKIIGATNPAESAPGTIRGDFAIDIGRNVIHGSDGVESARKEIALWFPEGIAEWQSSLHPWIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMF7</accession>
    <name>A0A068UMF7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030100001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMF7"/>
    <dbReference type="Gramene" id="CDP09680">
        <property type="protein sequence ID" value="CDP09680"/>
        <property type="gene ID" value="GSCOC_T00030100001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMF7"/>
    <dbReference type="OMA" id="CEAPECI"/>
    <dbReference type="OrthoDB" id="1926275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF187">
        <property type="entry name" value="AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="822" mass="92768" checksum="0A84B7AE7CEA28EB" modified="2014-10-01" version="1">MDDEIFSIGIYGMGGVGKTTLATHVHNNLLKEAKFSGHVCWITVSQEANIHKLQKDIAKFLPVDLSCEDNDRKRAAQLFQALKRRRNFVLILDDVWTHFDLENVGIPLRVDGSKLIITSRSLDVCRAMGCQKEVKVKPLCYQEAWTLFLEKLGCCRPLPPDIEEIAKSMVKNCAGLPLGIITVSGSMKGTDDIHEWRDALEELEDPVARQDCEVFKILHYSYSRLRDQRLKDCFLYCSLYPEDCEIPRDELIASFIRERLIDKRRTRQAEFDQGHALLNKLENACLLEGVVKIKEDDTEAKYVKMHDLMRDMALKITKTKPKYLVKAGIWLRDVPDKSEWKEDLDKVSLRFNVVSSIPLGISPYCPKLSTLSLWGNELTSIPCSFFAHFGALQVLDLSCNRSLEEQPNCISELERLAALLELDLSDTKISDVPEGLERLVNLKCLNMVQTNLEMISEGIISKLSCLQSLGIPRQVSVQVEELESLKQLEEFIGGFPEANSFCRFVRSRQRFNRPSFYVIQVGSGLLKGLSGHFQQMASKRVVFSFTNVNPGGKKRANILPDDIQELEICACQGLGSCLNDTFAEFNTQARGLTHCLIEGSSEIRSLLKLSSSEDQFVIKGQNSACAPLQNLKHLRLICLSNFNGLFEWDSVANAIPPPSTFSCLRSLFIDRCGKLKKLFTPRLLQSVQSLEVLKVWGCNELEEIVSNDEEGYFSFTSSSKDSCSRSTISCLPNLKKLAVLGDPKLRNICKGLLICNSIERIEVISCRNLESLPPFLPSINGQPSAPPALKVIQISLLGWESLKWENPYMKKILQPFVRYGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNV7</accession>
    <name>A0A068UNV7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00030448001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNV7"/>
    <dbReference type="FunCoup" id="A0A068UNV7">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09944">
        <property type="protein sequence ID" value="CDP09944"/>
        <property type="gene ID" value="GSCOC_T00030448001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNV7"/>
    <dbReference type="OMA" id="ATDHWIE"/>
    <dbReference type="OrthoDB" id="1915303at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNV7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35307:SF3">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35307">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="759" mass="86250" checksum="500FD0B8C4E785A4" modified="2014-10-01" version="1">MGRTGCTIDGSLDDSKFNQPIPWIGLYVAAASAACAIAMAIDTLHGLRYKKIWFPSKFFSLNATSLTLLAVATKLSVDLNTSMPQRQDQLAKLSSTVFICTVMANFMPSLGNMESKELLANLVALGIFAITVIVNICIQLGTGVIYVFWREYAVTMAVMIILLALMISSALTIPMTKSYFDLKYKKKHKLAVKECNDKSNRCPSQKASHRLKEDLTKYWIMAHTCNPQFVMARIATCSASGAFCLLSTATLAEAMIHCFFMPWDFKFCAGDSDYKWSTTLILIIQTVAIAVGTVAPASRWFATINFRCPKRAHKACKKKFKLEKYWTLKLKQLKECPLESRLYSRFCRKLAHNLKGKILDLCIWMQIGVVFLSKQIRFISLFFIIRFLISYRSFSNMIRRLNTSNSMSLYNSELESQPNPMQDLGRFVMHLEGEEEFIHMMTTKNCDATGHWIRMGQKQQPKHAIQLLEKLKSSKEFEGVIKFDSDLVHSLDSEEPPNCWALPVVTLTSIAVALPKVDRDLVKQLINSVHEALKYINFIEDNLDAKKDLINVRKAAEVLWVGVDLHYKWMDVDLHQLSLQDKCPKVIFEELAEKAKQRFKEFKEKDPIAALRENASKWPTNLLVANSMYRICQTLVLSSDSGEWECGKTAFEKLSAMITEIAGACFTNLHHAISEQCHQSAIEEREDRVRNAILLLGKTEKILEILEQQPLPSSNPEHLLYIDHWRMLSKRKDLLECNSSPTKTDTASSNSPDLYLTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPD3</accession>
    <name>A0A068UPD3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030774001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPD3"/>
    <dbReference type="STRING" id="49390.A0A068UPD3"/>
    <dbReference type="Gramene" id="CDP10152">
        <property type="protein sequence ID" value="CDP10152"/>
        <property type="gene ID" value="GSCOC_T00030774001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPD3"/>
    <dbReference type="OMA" id="YHIHASC"/>
    <dbReference type="OrthoDB" id="1036688at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288:SF68">
        <property type="entry name" value="DC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288">
        <property type="entry name" value="PHORBOL-ESTER/DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DC1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP10152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="242" mass="26959" checksum="5B88EC66F0DC0A7B" modified="2014-10-01" version="1">MEYKHFSHQHNLNIYKVQQGQICRCHGCQSLCHDSIYACWACDFFLHEHCGNATRYVNHPAHPLHPLILIPSPTYCSGSFVCNACGEIGNAFSYCCALCEIDLHLNCAFMPPKVSHKAHQHELVVSVGSPDRKGAPEFCKICTKELNSKNWSYCCLKPECDFRVHTFCATSEVKPGLYQGDDPDSEIPEPNSAATEANGNQPKPAPPKPSDPAAELLELQLQMQMAQQLAQMMASFNLSQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPG0</accession>
    <name>A0A068UPG0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho GDP-dissociation inhibitor 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00031000001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739128">
        <property type="protein sequence ID" value="CDP10311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPG0"/>
    <dbReference type="STRING" id="49390.A0A068UPG0"/>
    <dbReference type="Gramene" id="CDP10311">
        <property type="protein sequence ID" value="CDP10311"/>
        <property type="gene ID" value="GSCOC_T00031000001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPG0"/>
    <dbReference type="OMA" id="CARTKVI"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPG0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF61">
        <property type="entry name" value="OS01G0913600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP10311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24733" checksum="5ACCEAEF6CA0C6B3" modified="2014-10-01" version="1">MSASVETLSPSKHSARVSPFNESDDQSRMKKGIKNEQIKQEEAEENGSKSDVDIDEREKDDLSLKCNKALQVSSSMPLEKDKVEIKSISIMCRGRPEIVLSEPFASSPKALLFILKEGSRYRLRFNFIVSNKIVTGLRYVNTLWKAGMRVDKSEVCLGSFSPKEEPYSYELEEDTAPSGIFVRGLYCARTKVIDDQQNCYLDIKYYFEIQKTWPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV03</accession>
    <name>A0A068UV03_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific lipid-transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00035878001</name>
        <name evidence="8" type="ORF">GSCOC_T00042673001</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739148">
        <property type="protein sequence ID" value="CDP12375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV03"/>
    <dbReference type="STRING" id="49390.A0A068UV03"/>
    <dbReference type="Gramene" id="CDP12375">
        <property type="protein sequence ID" value="CDP12375"/>
        <property type="gene ID" value="GSCOC_T00035878001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP15101">
        <property type="protein sequence ID" value="CDP15101"/>
        <property type="gene ID" value="GSCOC_T00042673001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV03"/>
    <dbReference type="OMA" id="CDTVYDG"/>
    <dbReference type="OrthoDB" id="1890443at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01960">
        <property type="entry name" value="nsLTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000528">
        <property type="entry name" value="Plant_nsLTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33076">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00382">
        <property type="entry name" value="LIPIDTRNSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007371710" description="Non-specific lipid-transfer protein" evidence="5">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP12375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="124" mass="13228" checksum="2D1D54417EF44981" modified="2014-10-01" version="1">MAFTTMAKASSLKPLVFVLFVSMLIMSFFRSGQAQISCDTVKNDLSPCIGFIMNGGKVPPACCSGLNTLLSLAKTRTDRQSACSCLKSVAESATDDQLKNAAQIPHSCGVNLPFKISRDVDCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVN1</accession>
    <name>A0A068UVN1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00035779001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVN1"/>
    <dbReference type="Gramene" id="CDP12314">
        <property type="protein sequence ID" value="CDP12314"/>
        <property type="gene ID" value="GSCOC_T00035779001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVN1"/>
    <dbReference type="OMA" id="LTHREIM"/>
    <dbReference type="PhylomeDB" id="A0A068UVN1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658285" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="8127" checksum="D4DB386960C88CB7" modified="2014-10-01" version="1">MAAKSSQESLLVVAFVIFAILVSSTIPSHAAGSSGLTHREIMQKPSCPPCICCHKELPPPDCCYCACYVTESGNEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWM8</accession>
    <name>A0A068UWM8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00036396001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739153">
        <property type="protein sequence ID" value="CDP12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWM8"/>
    <dbReference type="FunCoup" id="A0A068UWM8">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWM8"/>
    <dbReference type="Gramene" id="CDP12672">
        <property type="protein sequence ID" value="CDP12672"/>
        <property type="gene ID" value="GSCOC_T00036396001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWM8"/>
    <dbReference type="OMA" id="CCEECTS"/>
    <dbReference type="OrthoDB" id="1872342at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWM8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1780.10:FF:000005">
        <property type="entry name" value="protein SUPPRESSOR OF MAX2 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058680">
        <property type="entry name" value="NBD_SMAX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051650">
        <property type="entry name" value="SL_signaling_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43572">
        <property type="entry name" value="CHAPERONE PROTEIN CLPD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43572:SF3">
        <property type="entry name" value="PROTEIN SMAX1-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23569">
        <property type="entry name" value="NBD_SMAX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114451" checksum="0AE57221206E2659" modified="2014-10-01" version="1">MRAGASCAVQQTLTSEAASVLKHSLSLARRRGHAQITPLHVAATLLSPRVSLLRRACLKSQPRQASSHPLQCRALELCFNVALNRLPTTPGPILHGQPSLSNALIAALKRAQAHQRRGCIEQQQQQPLLAIKVELEQLVLSILDDPSVSRVMREAGFSSTAVKKNLEDCSVSSVFQCYNSSGGIYSTPSSPPSENPNSIWHSHFLSYTSEQNPLVFSPQKILPRNPINITDAPAVSVKEDIKLVVEVLLRKKRKNTVIVGDSASITEGLVTELMGKVEKGDVPEELKSAHFIKFHFSAAPLKFMKREEVELNVSDLKRKVETLASGGKGVIIYTGDLRWTVENTMSEGEDTGGFCSKEYSGYSPVDHLVGEIGRLLSCYNNSNTKVWLVATANYQTYMRSQMKQPPLDVQWALQAVSVPSGGLGLSLKATSVQDTSLASLSKSTFEVIEQKPNVAKEEQIEAFICCPDCTSNYEKEVSFNSNQNSCNTKDSDLAYWLKPPGRNVAEKDDTVELKRKWIKLCQNLHQVRQNQNHTRSAFSKQCSPGKNQSYNSYPWWPSYNSMFVDSKSISFAHASLKPNQNSNSVPRFRRQQSCHIEFNFGSGNSKCTEEPNLDSLRLKEDKDEKITLALGNSQISDAVNSTEKANEDADLCKLLQENVPWHSGIIPAIVEALMNSKELKKDTWLVIQGNDLIGKRRIALGIAESLIGSADLLFYINLRTRQNTPGKCSEVLQNVVRNHGRLVAVLEDIDCADPDFLEFLADSIRAGKMGSFYKKDGSSCEPIFILTKADLSCYDNESKKMDPVIQMEILVTERTSNSTVFGPDHKRKTDWDFPDNNKIPRKSEMESGFKIPVENGEKELTPQLSSNTLDLNMKADEEESDDQTKEFSPISSDLTSNDQQNPLGFLDLIENHFILNRDLTQGRQMTEMFLNKIRASFEKIFGSKNLDCFTVEHNVLEQISLGSATFLNSLFEEWLKNIFQPTLKMVNTIGKEGISMRLSLRGNAKGNELNSGFKGSCLPKSVPVSYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXC7</accession>
    <name>A0A068UXC7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00037847001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXC7"/>
    <dbReference type="Gramene" id="CDP13076">
        <property type="protein sequence ID" value="CDP13076"/>
        <property type="gene ID" value="GSCOC_T00037847001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXC7"/>
    <dbReference type="OMA" id="WHINLSK"/>
    <dbReference type="PhylomeDB" id="A0A068UXC7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="77"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="4">
        <location>
            <begin position="496"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="854" mass="96484" checksum="8899201CCD290F63" modified="2014-10-01" version="1">MCWTSSTMKIFVGRLASKIRDINMNLERINRQANDVGLVFRFQIEAALPAATGAATSRQTDSILVPNVVGRVDDESKIVDMLSSPSEKVLSVIPITGPGGLGKTTLAKSVYNNPKIDGHFGQKIWVCVAKEQIKIMELFKLILVQLTREEVKVDNREVIVKEIGEKLKGKKYFLVLDDVWDYDQGLWSDYFNTLMGLNETKGSWCLLTTRSKLVADVVSTHLKMNSGPYFLGKLSSEECWSIIKGKVMSAGEEVPEELEALKKQILGRCDGLPLAASLIGGLLLNNRREKWHSIVQEILLQNSLLEKVEKQRGTYYKMHDLVHDFAKSVLNPKSSSQGRYLALHSYEEMAENVRRNKAASIRSLFLHLGGGISADMDTLSRFKHLHVLRLSGYYIVFLPSSIGKLLHLRLLDISSSGIRSLPESLCKLYNLQTLTIDDDDELERGFPKRMSDLISLRHLNYYHCDAEFKMPMQMGRLTCLQTLKFFNVSQERGRGIEELGTLKYLKGSLSIRNLGLVKGKEAAKQAKLFEKPDLSCLVFEWESGDRESDNREEDVLEGLQPHPNLQELVIYSFMGNKFPQWHINLSKLEVLWIVDCKRCSELPSLGQLPSLKSLYLEGLDNIRFIGDEFYGSSTRRRKFFPALEELYVAVGNLVEWKGADQVGEAEADVFPMLRDFRIRGCPQLTALPCSCKSLYVQGCDNLTSIKTGYGTASVEELWIHSCDNLRELPDLDLFGSSLQRLTISFCPRLISLGVNGQKSPLLLCLEKLKIEYCEGLTTISDKMFQSCRSLRSLEVMRCPNLVSFSLNLQEAPSLERFILKECPKLIPYCEGFNGFAFATSLKELSINIFTTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UY77</accession>
    <name>A0A068UY77_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00038465001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UY77"/>
    <dbReference type="STRING" id="49390.A0A068UY77"/>
    <dbReference type="ESTHER" id="cofca-a0a068uy77">
        <property type="family name" value="Plant_carboxylesterase"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP13505">
        <property type="protein sequence ID" value="CDP13505"/>
        <property type="gene ID" value="GSCOC_T00038465001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UY77"/>
    <dbReference type="OMA" id="HVFHPES"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UY77"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF635">
        <property type="entry name" value="OS07G0162700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="70"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="310" mass="34443" checksum="B125A1278234A34B" modified="2014-10-01" version="1">MSIVDESPGYMQVLSDGSVKRFAPETAAASTESSNGYKSRDVVIDSSKPTTARIFLPDVSESVAGQLPVLVYFHGGGFCIGSTTWLGYHHFLGDLSAVSKSIVLSVDYRLAPENKLPIAYDDCYSSLEWLSNNASSEPWLEKADLLRVFLSGDSAGGNIVHQVAVKVIKDKVSRVRIKGLIPIHPYFGSEKRTELEMAEESAGHVQSNDMFWRLSLPVGENRDYLGCNFEKTELSGSEWDQFPRVLVFVAGLDFLKERGVMYADFLQKKGVQKVSLIEAEGESHVYHVFHPKSEATTLLQKQMSDFMHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZ99</accession>
    <name>A0A068UZ99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00038988001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZ99"/>
    <dbReference type="STRING" id="49390.A0A068UZ99"/>
    <dbReference type="Gramene" id="CDP13865">
        <property type="protein sequence ID" value="CDP13865"/>
        <property type="gene ID" value="GSCOC_T00038988001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZ99"/>
    <dbReference type="OMA" id="KMLVFRG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZ99"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF43">
        <property type="entry name" value="CELL DIVISION CYCLE 20.2, COFACTOR OF APC COMPLEX-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="131"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP13865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="458" mass="51060" checksum="EBEC219C0CF33F23" modified="2014-10-01" version="1">MGENPSWVLQSGGYSPTRLRSPVEYDFPGDRFIPNRSLMDLDHAKSLLTNRTTKELEKPKYSEEYSRKLKENLTLDVEGRPYRMLVFRGSPKSSRKSSRLIDEMRRSDEDKTNTRDSNKNRSFPKKESLVLDAPNLSDDFYMNVLDWGSGNLIAVALGSALYTWNPSNRAIHKLLDVDSQCDYPTSLAWSGDARKIAVGHMCSDVQLWDAETSKLVRSLRGHQNKVVSVEWNGHILTSGGNDKAIINHDVRAKKSLTCYLRVHTRGVCSLKWSRRSNILASGGDDNLVYIWHASKMSSSHYMYRLNAHSAGVKALAWCPYNSDVLASGGGLLDGSLKLWNVQKGVCINSINTHAQVCALQWNRHQKEILSGHGFSWGNADCGNQLCLWKYPSMSKIGGSSKSDSRVLHLTQSPDGLRVASAGANETISIWEVFGPPQANEPRSSGLDSLLAFRASPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZB6</accession>
    <name>A0A068UZB6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00038590001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZB6"/>
    <dbReference type="STRING" id="49390.A0A068UZB6"/>
    <dbReference type="Gramene" id="CDP13589">
        <property type="protein sequence ID" value="CDP13589"/>
        <property type="gene ID" value="GSCOC_T00038590001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZB6"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZB6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045281">
        <property type="entry name" value="CONSTANS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319:SF110">
        <property type="entry name" value="CCT MOTIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCT" evidence="4">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="248" mass="27561" checksum="34A839C4E035E39F" modified="2014-10-01" version="1">MVPFDSDISCSSTPSSSSSSLSSIAAALSYPTAEPLGPSDTTHDPALVGPTSYATLSGSLFGISGNEGLSSGAANYCHQHDRAYDFGDQECGAPASNFWPLYPRAMTSDNWEIQGGVAQRMEEATLKVSRYSAEERKDRILRYLKKRSQRNFNKTIKYACRKTLADKRVRVRGRFARNNECCEDDQTLVLVKTDSNLQQADSCYNIPADDQIMKSYDEEWLQEAIASLMCYRIAPDNGLELPDKYLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0W2</accession>
    <name>A0A068V0W2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00040890001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>deacetylisoipecoside + H2O = deacetylisoipecoside aglycone + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:78887"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58091"/>
            <dbReference type="ChEBI" id="CHEBI:229557"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:78888"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739169">
        <property type="protein sequence ID" value="CDP14435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0W2"/>
    <dbReference type="STRING" id="49390.A0A068V0W2"/>
    <dbReference type="Gramene" id="CDP14435">
        <property type="protein sequence ID" value="CDP14435"/>
        <property type="gene ID" value="GSCOC_T00040890001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0W2"/>
    <dbReference type="OMA" id="IPTRGYA"/>
    <dbReference type="PhylomeDB" id="A0A068V0W2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033075">
        <property type="term" value="P:isoquinoline alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000022">
        <property type="entry name" value="Beta-glucosidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF137">
        <property type="entry name" value="MYROSINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP14435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56412" checksum="8AC9996962F1E478" modified="2014-10-01" version="1">METPESHVFPTEGSLRRQDFPNGFLFGASASAFQYEGAPDIDGRGPSIWDTFLIDRHPEIVQAGGLDAIAHYRHYKDDVRVMKEMGLDSYRFSISWPRILPTGRRTNGAGINEKGIQFYNSLIDELLANGIKPMVTIFHWDVPQALEDEYHGFLDKKIVIDFVDYVDLCFSRFGDRVKHWITFNEPWSFSVGGYATGTLAPGPSEFAGAPKQGNAATEPYIVSHHQLLAHAAAVQLYRQKYQRSQKGKIGITLVSTWAVPYHNTKEDRDAAQRAIDFMFGWFMDPITHGDYPSSMRSLVGHRLPKFSKPESELLKGSFDFLGFNYYTANYVLNEAGPPYTLDPRAKCTPYRNGKPIGERAASDWLYVYPKGILEHVDYIREKYNNPPIYITENGRDEFNEKNLSFWLAFFDPKRISFHYRHLRFLKKAIDKGANVKGYYVWSLMDNLEWSTGFNSRFGMNFIDYADGLKRYPKLSAGWFKFFLHNDEETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V240</accession>
    <name>A0A068V240_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00041110001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V240"/>
    <dbReference type="STRING" id="49390.A0A068V240"/>
    <dbReference type="Gramene" id="CDP14579">
        <property type="protein sequence ID" value="CDP14579"/>
        <property type="gene ID" value="GSCOC_T00041110001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V240"/>
    <dbReference type="OMA" id="PRYVHHD"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V240"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000001">
        <property type="entry name" value="Protein SRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="208"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP14579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="365" mass="41440" checksum="05734A756FDD3C88" modified="2014-10-01" version="1">MEESPLQFVNFGKSLIVPSVQELAKQPISKIPPRYVHHDEESPIVSHETSLPAVPVIDVERLLSENSMDSELEKLHLACKDWGFFQVVNHGVSTSLLDCLRNEITDFFKLPFEEKKALWQEPENHEGFGQLFVVSEEQKLDWSDMFYITTLPDKLRKVELFEKLPLKLRDAMEAYSLEVKILAMTLLREMAKVLKIDEEELKGLFSDGVQSMRMNYYPPCPEPEMAIGFNPHSDADALTILFQLNGTPGLQIRKDGRWLPVTPLPDALIVNVGDIIEILSNGLYRSIEHRATVNSDRERLSIATFYSSNLDAEVAPARSLIGPHNPAGFRSIPVEKFIREFFAAKVHGKAHLEFMKIQAGEHQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3P9</accession>
    <name>A0A068V3P9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00043154001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3P9"/>
    <dbReference type="FunCoup" id="A0A068V3P9">
        <property type="interactions" value="1376"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3P9"/>
    <dbReference type="Gramene" id="CDP15425">
        <property type="protein sequence ID" value="CDP15425"/>
        <property type="gene ID" value="GSCOC_T00043154001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3P9"/>
    <dbReference type="OMA" id="PSPFCKI"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3P9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03041">
        <property type="entry name" value="GST_N_2GST_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000120">
        <property type="entry name" value="Thioredoxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000138">
        <property type="entry name" value="Thioredoxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45288">
        <property type="entry name" value="THIOREDOXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45288:SF1">
        <property type="entry name" value="THIOREDOXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01181">
        <property type="entry name" value="SUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01202">
        <property type="entry name" value="SUF2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="260"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="339" mass="37347" checksum="1A36E0A459A9BBF7" modified="2014-10-01" version="1">MAGILSSTTTPIFGPFLGSKTLSTKRPFHVKLSAQSSETPIAASTSVSTKEEPSTSSGPSFSPPPNFRPPQPKPFSVRPDKNLDILGGSLALIFRLGTGVFVSGYSASFVPKNEIPPNQYALEIAGFKVKETSKLGPRPERPIEIYEFESCPFCRKVREIVAILDLDVLYYPCPKNGPNFRPKVVEMGGKRQFPYMVDPNTGVAMYESDEIIKYLVGKYGDGNVPIMLSLGLLTTLTEGFAMIGRMGKGSSYTPSKMPLKPLEIWAYEASPFCKVVREILVELELPHILRSCARGSPKRQVLYEKAGHFQAPYLEDPNTGVQMFESAEIVEYLKATYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V428</accession>
    <name>A0A068V428_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00015421001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V428"/>
    <dbReference type="FunCoup" id="A0A068V428">
        <property type="interactions" value="1534"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V428"/>
    <dbReference type="Gramene" id="CDP15545">
        <property type="protein sequence ID" value="CDP15545"/>
        <property type="gene ID" value="GSCOC_T00015421001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V428"/>
    <dbReference type="OMA" id="IMDVSME"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V428"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010213">
        <property type="term" value="P:non-photoreactive DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
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        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010332">
        <property type="term" value="P:response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="9">
        <location>
            <begin position="118"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="411" mass="45940" checksum="0F44CA1B209290C7" modified="2014-10-01" version="1">MAEGDDREQPPQPPNSNDQRPKFVINIPSYEEVMESSQPRTAPSSFFEPSTSFSQAFNFLKNSDFYSPPLPPPPPPPPLPPQPPSSAIPRQIGQSEGPSTSSTPSFSAYAPVPSRNAILVSHRQKGNPLLKHIRNVRWSFADVVCDYSLGQNACALYLSLRYHLLHPDYLYYRIRELPKNFKLRVVLCHVDVEDVVKPLLEVTKTALLHDCTLLCGWSLEECGRYLETIKVYENKPADLIQGQMDSDYLSRLNHALTTVRHVNKTDVVTLGSTFGSLSNIMDASMEDLARCPGIGERKVKRLYDTFHEPFKRVVPIRPSVPANSVHVNAEATSASENKEDDKEIEDANKKRKKESELTVKSALSVAFAKYSERIGRKNNNNSEKNETEEESIATVEANDEPMCNGEGPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4C1</accession>
    <name>A0A068V4C1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00043067001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739182">
        <property type="protein sequence ID" value="CDP15364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4C1"/>
    <dbReference type="Gramene" id="CDP15364">
        <property type="protein sequence ID" value="CDP15364"/>
        <property type="gene ID" value="GSCOC_T00043067001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4C1"/>
    <dbReference type="OMA" id="IWSMGFD"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4C1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR A-3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="460" mass="51395" checksum="9B35C3D65786F5F9" modified="2014-10-01" version="1">MVSPFVDLESRQHLQEIVPGILSGGTITTEAARSFPGMPQPMECLQGTPVPPFLSKTFDLVDDPALDSIISWGASGQSFVVWDPVEFARRILPRNFKHNNFSSFVRQLNTYVSVRLYGLLLACVAILYGFRKIDADKWEFASESFLRGKRHLLKNIQRRKSPHSHQLGGSSGSTGEAGKIVLEGEVEKLRKERSLMMQEVFELQEQQLGTIQHVEAVNEKLQAAERRQKLMVSFMAKLFQNPDILDRLKQIKEQKQITSSRTMRKFLKHQPHEPGKAESFLEGQIVKYRTNFRDLATPSAAPEFDPGAVEQLPEFTLQEPSGGGFSSQGTEDTLLKGKTVVPPEVIPEYFVTSPDDLAKEKNFPEYSSPDIESMLKEQEPWSMDFEAGAGVSSSSNEIWGNAVNYEIPELMVSSGLPDIWNLGSLPAAGSSGAEKWPDDESPFSKLDDQVGQHKDESSNF</sequence>
</entry>
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    <accession>A0A068V4F9</accession>
    <name>A0A068V4F9_COFCA</name>
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        <name evidence="2" type="ORF">GSCOC_T00015432001</name>
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        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>lamiids</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP15551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="34" mass="3620" checksum="3753725D15DDBBA0" modified="2014-10-01" version="1">MGSRIMISGNLDPERKRSGGLRTKQAGRGSCRGS</sequence>
</entry>
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    <accession>A0A068V6Z0</accession>
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        <recommendedName>
            <fullName evidence="9">PGG domain-containing protein</fullName>
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    <organism evidence="10 11">
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
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                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
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                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
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                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDP16302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068V6Z0"/>
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        <property type="protein sequence ID" value="CDP16302"/>
        <property type="gene ID" value="GSCOC_T00018085001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6Z0"/>
    <dbReference type="OMA" id="QFNTICI"/>
    <dbReference type="PhylomeDB" id="A0A068V6Z0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF50">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN ITN1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="9">
        <location>
            <begin position="412"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP16302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="583" mass="64902" checksum="D473250627A999EB" modified="2014-10-01" version="1">MHPDLYRAAQSGNWDEIQKFANKLYSQRNAGGNSVLHVVAWQCSNSADAVTRILEREPRLLLIRNDQDETALHLAASMGRSYVVQAIMGFVEGTKNRKSRDKMLRELLGARDRRGNTALHEAVRNNFYEAAKVLVEADRELRYRVNFAGESPLYLAVENENRGIAILILSNCESPSYDGPDERTALHAAALCKFPECEEVIKLMLEKLPEVTKKVDKIGWTALHCAAKFDRPEGVRLLVSKGKTMAYVYSKRRDSYKTALHIAVISGSLGVIREILNYCPDCWEAVTKQRQNILHLAVKNEHHEVLEFILRSPWAGHLINRQDHHGNTPLHLYVATERLDGQNLVSHPALNLNAINEAGLTPLGQITESENLTARQILIKDELEQAGGTRGYRNVATVKKILQAASPDEVKRVEKLSKNYSIVATLIATVTFAAVFQVPGGYNSDGPHKGMAVLGKKAAFIAFVILDSLAMFASIVAVVGHIMLMVTKNYRLKLAVVLAIVVEVGLALEFMTMAFITGLVAVLPNLTAMILLCAVCAWLGLHLFIWTRFVGSPTKFLSSLLCLHSHMLQLFARKRGQGMYLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9B6</accession>
    <name>A0A068V9B6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-amyrin 28-oxidase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00011697001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739230">
        <property type="protein sequence ID" value="CDP17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9B6"/>
    <dbReference type="STRING" id="49390.A0A068V9B6"/>
    <dbReference type="Gramene" id="CDP17152">
        <property type="protein sequence ID" value="CDP17152"/>
        <property type="gene ID" value="GSCOC_T00011697001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9B6"/>
    <dbReference type="PhylomeDB" id="A0A068V9B6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF53">
        <property type="entry name" value="BETA-AMYRIN 28-OXIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51964" checksum="088D62B89E0593D4" modified="2014-10-01" version="1">METFSLYLLSLAVVLVSFIFLGILSQRYNSNRSKVPPGTFGFPLIGETIQFLASGPEKFFHRRMEKYSGDIFTTSLFGEKVAVVCGAAGNKFLLYTANHQLTPWIPSATFKLLNWMDSAGQSYKQSLSGGRIFLNKEMLKPEILRQYITIMDSLARQHINTYWDPSQVVKVYPLSQKVVLNSNQFAWHHIQSCFERDQNTKAAILEYHCGKEKDCFGEQGKSRFGRIVSHPPGRERQFHVQLRDWCLYCEFNASQLRSSKCISYIVLMYLAELPHIYDMVYKDSLQYVKYMEIAESKAPEELLNLEDIKKMKYSWNVIYEALSLTPPSLVNFREAQTDVNFAGFTIPKGWKVLWSPFTTNKNPKYFHDPETFDPTRYEGDGPTACTFLPFSAGPRMCPGKEYSMFLILVYIYNVVRNFKLQKMIQDEKIQYRVSAVPANGLPIRLQPHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAU7</accession>
    <name>A0A068VAU7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00013227001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739256">
        <property type="protein sequence ID" value="CDP17682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAU7"/>
    <dbReference type="Gramene" id="CDP17682">
        <property type="protein sequence ID" value="CDP17682"/>
        <property type="gene ID" value="GSCOC_T00013227001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAU7"/>
    <dbReference type="OMA" id="AHEITHP"/>
    <dbReference type="PhylomeDB" id="A0A068VAU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="378" mass="42386" checksum="EEBC42570981ACBD" modified="2014-10-01" version="1">MEQILHTKGGGDEESYAKNSTFQRLVFMNVNHALNRSIQGFCQANLAETECIRVADLGCASGPNTLLAVESIIDSINRERHNLNILKLPNIQVFLNDLMSNDFNSIFKLLPSFYQKLKESYGCGSRSCFIAAMPGSFYGRLFPDNSMHFILFLQTSLAFSGSPISGFIEGLPLNKGNIYIGKTSPKSVHDAYLDQFDRDFTNFLSIRADELVSGGHLFVTLTPKIDDPVAYNVQDLLGMTMNDMVSEGLIEEKALDTFNLPHYRPSLEEVKAIIEKNRALKIRYLDNIQLRVIGVEAAHCGKGYVFNTNTNAKYMARSLRAIYEPIFQAHFGDGIMNDFFTKLAANISQHQRKMKSPINSLVLPSPEHESRTCILCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB62</accession>
    <name>A0A068VB62_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00003688001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739287">
        <property type="protein sequence ID" value="CDP18070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB62"/>
    <dbReference type="FunCoup" id="A0A068VB62">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB62"/>
    <dbReference type="Gramene" id="CDP18070">
        <property type="protein sequence ID" value="CDP18070"/>
        <property type="gene ID" value="GSCOC_T00003688001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB62"/>
    <dbReference type="OMA" id="MSAESSH"/>
    <dbReference type="OrthoDB" id="1435597at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14703">
        <property type="entry name" value="bZIP_plant_RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000009">
        <property type="entry name" value="probable transcription factor PosF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044759">
        <property type="entry name" value="bZIP_RF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690">
        <property type="entry name" value="TRANSCRIPTION FACTOR POSF21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13690:SF124">
        <property type="entry name" value="TRANSCRIPTION FACTOR RF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="248"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP18070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="433" mass="47024" checksum="F10912ADA10B1786" modified="2014-10-01" version="1">MDRDKSVNHGGGLPPSGRYSSFSPPGSSYGVKPEQSGSSTLPPIGPGGISESTHFGHGMSSDSSRFSHDISRMPDNPPKNLGHRRAHSEILTLPDDISFDSDLGVVGGLDGPSFSDDTEEDLLSMYLDMDKFNSSSATSAFQVGESSSLAAGVLGSSSTAASASTSLAPPSEIVSGISDKPRVRHQHSQSMDGSTTIKPEMLTSGAEEPSQADAKKAMSATKLAELALIDPKRAKRIWANRQSAARSKERKMRYIAELERKVQTLQTEATSLSAQLTLLQRDTNGLTAENSELKLRLQTMEQQVHLQDALNDALKEEIQHLKVLTGQIPNGGPMMNYPPSFGANQQYYSSNHAMHTLLTAQQFQQLQINSQKQQHQFQPHQMHQFQQHQLPQSLIQQQDHPMQQTGDLKLRGSLPTPAQTDNASDTSASLSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBR2</accession>
    <name>A0A068VBR2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00011812001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739303">
        <property type="protein sequence ID" value="CDP18250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBR2"/>
    <dbReference type="FunCoup" id="A0A068VBR2">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBR2"/>
    <dbReference type="Gramene" id="CDP18250">
        <property type="protein sequence ID" value="CDP18250"/>
        <property type="gene ID" value="GSCOC_T00011812001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBR2"/>
    <dbReference type="OMA" id="ICAAQNN"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBR2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006971">
        <property type="term" value="P:hypotonic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000693">
        <property type="term" value="P:positive regulation of seed maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF31">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="132" mass="15145" checksum="9EE913A12F88015D" modified="2014-10-01" version="1">MSSESDQRYAMMDEKKRKRMISNRESARRSRMRKQKQLQDLTDEMGRLEVANNGIEGKIDGITEKYMICAAENNVLRARLTELTERLRSLNDVIKNLEMVGDATQLPDPLLKPWQVSCSMQPIPASSGIFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC40</accession>
    <name>A0A068VC40_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00000705001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional corepressor. Negative regulator of jasmonate responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739232">
        <property type="protein sequence ID" value="CDP17223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC40"/>
    <dbReference type="FunCoup" id="A0A068VC40">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VC40"/>
    <dbReference type="Gramene" id="CDP17223">
        <property type="protein sequence ID" value="CDP17223"/>
        <property type="gene ID" value="GSCOC_T00000705001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC40"/>
    <dbReference type="OMA" id="CLWSIDS"/>
    <dbReference type="OrthoDB" id="1602884at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VC40"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010072">
        <property type="term" value="P:primary shoot apical meristem specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001382">
        <property type="entry name" value="TOPLESS-related 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000479">
        <property type="entry name" value="Topless-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027728">
        <property type="entry name" value="Topless_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048419">
        <property type="entry name" value="Topless_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083:SF2">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21359">
        <property type="entry name" value="zf_topless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1184">Jasmonic acid signaling pathway</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="13">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="913"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1111"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1115"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP17223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124925" checksum="1CA9122BDFAD283B" modified="2014-10-01" version="1">MSSLSRELVFLILQFLEEEKFKESVHKLEQESGFFFNMKYFEEKVHAGEWEEVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDRQDKAKAVEILVNDLKVFSTFNEDLYKEITQLLTLNNFRENEQLSKYGDTKTARSIMLIELKKLIEANPLFREKLVFPTLKASRLRTLINQSLNWQHQLCKNPRPNPDIKTLFTDHTCTPPNGALAPTPVNMPPAAAVAKPAAYTSLGTHGPFPPTAAAANANALAGWMANAAASSSVQAAVVTASSLPVPPNQVSILKRPITPPATLGMVDYQNAEHEQLMKRLRPAQSVEEVTYPTVRQQPSWSLDDLPRNVAFTMHQGSTVTTMDFHPSHHTLLLVGSNNGDITLWEVGMREKLVTKPFKIWEIQACTLPFQASVAKEGPFSVSRVTWSPDGTFIGAAFSKHLVHLYAYAGPNDLRQHLEIDAHTGGVNDLAFAHPNKQLCVVTCGDDKLIKVWDLTGRKLFNFEGHEAPVFSICPHQKENIQFIFSTAIDGKIKAWLYDNMGSRVDYDAPGHWCTTMLYSADGSRLFSCGTGKEGDSFLVEWNESEGAIKRTYTGFRKKSNGVVQFDTTQNHFLAVGEDSQIKFWDMDNNNILTFTDAEGGLSSLPRLRFNKEGNLLAVTTADNGIKILANAAGMRSLRAAENPGFEALRSPMEAAAIKASGSSVANVPPVNCKVERSSPVRPSPILNGVDSMSRSMEKPRTLDDVNDKMKPWQLAEIVDPVHCRMVTMPESTDAGNKVARLLYTNSGVGLLALGSNGVQKLWKWVRNEQNPSGKATANLVPQHWQPNSGLLMTNDVSGVNLEEAVPCIALSKNDSYVMSAAGGKVSLFNMMTFKVMTTFMAPPPASTFLAFHPQDNNIIAIGMEDSTIHIYNVRVDEVKSKLKSHQKRITGLAFSTTLNILVSSGADAQLCVWSIDTWDKRKSVPIQLPAGKAPTGDTRVQFHSDQIRLLVSHETQLALYDAAKIDRIRQWVPQDVLSAPISYAAYSCNSQLVYASFCDGNIGVFDADTLRLRCRVAPSAYLSQAVLNGSQAVYPLVIAAHPQDPNQFAIGLTDGSVKVIEPQESEGKWGVTPPVDNGILNGRAASSSTTSNHGGPDSVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC82</accession>
    <name>A0A068VC82_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00010852001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739312">
        <property type="protein sequence ID" value="CDP18346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VC82"/>
    <dbReference type="Gramene" id="CDP18346">
        <property type="protein sequence ID" value="CDP18346"/>
        <property type="gene ID" value="GSCOC_T00010852001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC82"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="31" mass="3860" checksum="E38C6AC393E1572C" modified="2014-10-01" version="1">MIYVCILCTELLRRCLNMIQLREYIPKLRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCH1</accession>
    <name>A0A068VCH1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Thymidine kinase</fullName>
            <ecNumber evidence="2 15">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00006610001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Purine metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Pyrimidine metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 15"/>
    <dbReference type="EMBL" id="HG739304">
        <property type="protein sequence ID" value="CDP18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCH1"/>
    <dbReference type="FunCoup" id="A0A068VCH1">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCH1"/>
    <dbReference type="Gramene" id="CDP18262">
        <property type="protein sequence ID" value="CDP18262"/>
        <property type="gene ID" value="GSCOC_T00006610001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCH1"/>
    <dbReference type="OMA" id="NQENHYD"/>
    <dbReference type="OrthoDB" id="439028at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCH1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000051">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000948">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF12">
        <property type="entry name" value="THYMIDINE KINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 15" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="21992" checksum="0F6503A299E1ADF7" modified="2014-10-01" version="1">MFAGKTTSLLRRVKLESDSGRSVAMIKSSKDTRYATDAVVTHDGVKFPCWSMPDLSSFKQKIGVDAYEKLDVIGIDEAQFFDDLYDFCCETADLDGKIVVVAGLDGDYLRRSFGSVLEVVPLADTITKLTARCELCRKKAFFTLRKTEETKTEIIGGADVYMPVCRQHYVNIHVEAARSVLKPHNVQANVSLDKAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEM5</accession>
    <name>A0A068VEM5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polygalacturonase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00001677001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739445">
        <property type="protein sequence ID" value="CDP19166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEM5"/>
    <dbReference type="FunCoup" id="A0A068VEM5">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEM5"/>
    <dbReference type="Gramene" id="CDP19166">
        <property type="protein sequence ID" value="CDP19166"/>
        <property type="gene ID" value="GSCOC_T00001677001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEM5"/>
    <dbReference type="OMA" id="YRNIVMN"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEM5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000016">
        <property type="entry name" value="Polygalacturonase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658858" description="Polygalacturonase-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="41717" checksum="48B9C2C375462B9B" modified="2014-10-01" version="1">MASSLRASCIFLLSLTALLTITSAASFNVISFGAKSDGRTDSTQSFLKAWASACSSVQAATIFVPRGRYLIKAAVFRGPCKNRITVRIDGTLVAPDDYWGLGNSGYWLLFVQVNRLSVIGGTLDAKGAGFWACRASGRNCPVGARSITFNWVNDGLISGLTSINSQLMHVVVNSCKNVKVQNVRIVAPDLSPNTDGIHVRGSTGVTISGSSIQTGDDCISIGPGTRNLWMERIKCGPGHGVSIGSLGRDFNEDGVQNVTLINSVFSGSDNGLRIKSWARPTTAFVSNIKFQNIIMKNVENPIIIDQNYCPVNRGCPRQTSGVKIDQVIYQNIQGTSATPVAVIFDCSPSNPCRGIKLRDIKLTYLNRKAQSLCKNIGGTAAGVIMPESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF37</accession>
    <name>A0A068VF37_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00004335001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739307">
        <property type="protein sequence ID" value="CDP18308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF37"/>
    <dbReference type="FunCoup" id="A0A068VF37">
        <property type="interactions" value="1167"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VF37"/>
    <dbReference type="Gramene" id="CDP18308">
        <property type="protein sequence ID" value="CDP18308"/>
        <property type="gene ID" value="GSCOC_T00004335001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF37"/>
    <dbReference type="OMA" id="PADEYWK"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF37"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000043">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000021">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF228">
        <property type="entry name" value="PROTEIN IMPAIRED IN BABA-INDUCED STERILITY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="141"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP18308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="711" mass="78145" checksum="356784CDFBAE5C5A" modified="2014-10-01" version="1">MGCVTSKQAVSVTPAFDHSGVLRENGAGGIGGGAFGSGRSRVGSGGLGLGLEMDLKKVKKRGSTESGGGGSELGESGRASSNGGTGTGTGTGTGSESVSFRLGNLQKYVEGEQVAAGWPAWLSAVAGEAIHGWVPLRAESFEKLEKIGQGTYSSVFRARDLETGKIVALKKVRFDNFEPESVRFMAREIMILRRLDHPNVIKLEGLITSRLSCSMYLVFEYMEHDIAGLLSSPDIKFSEAQVKCYLKQLLSGLEHCHSRGVMHRDIKGANLLVNNDGVLKIADFGLANFCNFGQKQPLTSRVVTLWYRPPELLLGSTDYGSSVDLWSVGCVFAELLVGKPILQGRTEVEQLHKIFKLCGSPPDDYWKKSKLPHATLFKPQHPYESSLWETLKDLPKAAVILIETLLSVEPYKRGTASAALAAEYFKTKPYACDPSSLPKYPPSKEIDAKHREEARRKKPGGRARGPEATKRLTRKQNGFSKLAPEENLPVQPQGGHKISGYNASNCKEGDIVIGLEPPKPSNELKEEASHVKHASQGDVPFSGPLQVSGSSGFAWAKRRIDDSVRSRSRSSSRSLIFEPSGAVQLRNNLESKRNENSEALNGHGTNFKGHDSYERLNHVMVKDWSQLEHPDSFDASDGYHSQELSLALYQKEDLAIKRISLVYQDQGDKVEFSGPLLSQSQRVDELLEKHERQIRQAVRRSWFQRVKKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFW1</accession>
    <name>A0A068VFW1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00002169001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739584">
        <property type="protein sequence ID" value="CDP19454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFW1"/>
    <dbReference type="STRING" id="49390.A0A068VFW1"/>
    <dbReference type="Gramene" id="CDP19454">
        <property type="protein sequence ID" value="CDP19454"/>
        <property type="gene ID" value="GSCOC_T00002169001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFW1"/>
    <dbReference type="OMA" id="LATKRHT"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFW1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="175"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="440"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="561"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="954" mass="108822" checksum="CC04A710D8ED698B" modified="2014-10-01" version="1">MAETVLSFVLDQLSIFLREEGRLLGGLRHEVQLISDELGHMRAFLRVAETKEEDADPRLQEWIKQVREAAYDTEDVLDEFVARFAHHHATGFYGSVRKIFNSVKTLRARRKVAEQIQSIKARVKNISEGHQRYQSEFGGATQAAESLATVNNTTWRYSRDDALLVEEAELVGIDHPKQQLISQLLERDDSQLKVVSVVGMGGLGKTTLVKKVHEDLGIRRHFPVRAFVTVSQPCNFQELLKDLTRQLHNDLKKPVPESIETMTAIQLKQCVKDFLQQAGRYAIVFDDVWDVEFWNAIRFALPENGYGNRVMLTTRKADVASASCNKSQDYVYKMVPLSFEDSWTLFCNKIFKGNGCPAHLTDVAKGILGKCQGLPLAILAISGLLALKDLNIAEEWEIVRRSLVGELEGSGMLDRVKKILSLSYNDLPSHLKSCLLYLSIYPEDFEIPCGRLVQLWSAERFVGKREGMTVEDVGYNYLRELVNRSLIQVTQIFYEGIPYACRIHDLVREIVLSKAREQNMIAITTGQYTKWWSEKVRRLVVHSSSNNTEQHQESQCYSFNHLRSFITIESMNPLISRTLLSEVLKNSRLLKVLDLSDEETLEEIPNEIFNLYHLRHLNLCRTGVKVVPNFIGKLRNLENLDLRETQVKELPVEILKLQKLEHLVVYQKVDVSDTTYGYHGFKAPSKLGGLLALQSLTTIDASSGSVVVKEIGALTQLRRLGISNLRREDGKVLCSSLATLTSLRQLNIASIRNDGGDYEVMDLNHSLSSSMRSSFLQSLRMLVLRGRLEMMPQWIAHLQSLARIDLYWSGLRDEEDPLAPLHHLPNLVTIQFCGSYQGEGLCFKAGGFLKLKDLYLKKLEKLRWMEVEKGALPSLQELSLDTLPLLEELPLDIQHLSCLRKLGLYELGSQLMEKLENLNEETEDYRKIAHISEVVIELRTDEGWKRCRLWGKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGW7</accession>
    <name>A0A068VGW7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00002618001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739803">
        <property type="protein sequence ID" value="CDP19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGW7"/>
    <dbReference type="FunCoup" id="A0A068VGW7">
        <property type="interactions" value="2298"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGW7"/>
    <dbReference type="Gramene" id="CDP19832">
        <property type="protein sequence ID" value="CDP19832"/>
        <property type="gene ID" value="GSCOC_T00002618001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGW7"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="10250051at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="166" mass="17746" checksum="750865FFDAEB289D" modified="2014-10-01" version="1">MPPKFDPTQVVEVFVRVTGGEVGAASSLAPKIGPLGLSPKKIGEDIAKETAKDWKGLRVTVKLTVQNRQAKVAVVPSAAALVIKALKEPERDRKKTKNIKHSGNISLDDVIEIAKVMRPRSMAKDLAGTVKEILGTCVSVGCTVDGKDPKDLQQEIADGDVEIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VGX0</accession>
    <name>A0A068VGX0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00010989001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739783">
        <property type="protein sequence ID" value="CDP19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VGX0"/>
    <dbReference type="FunCoup" id="A0A068VGX0">
        <property type="interactions" value="1426"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VGX0"/>
    <dbReference type="Gramene" id="CDP19804">
        <property type="protein sequence ID" value="CDP19804"/>
        <property type="gene ID" value="GSCOC_T00010989001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGX0"/>
    <dbReference type="OMA" id="HPNEDMR"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGX0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1308" evidence="1">
        <location>
            <begin position="313"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="481" mass="53250" checksum="54E46CADDAD9489A" modified="2014-10-01" version="1">MESSETLIGAAQDAKKRCEALNDRIEGLRTQSSSSPTSNWKTTLLRLVHSELSFLNRFLISASLNNNRQSSLSVNVGHLESIVHILELPSISGISRVCKSIPLVSSQEKLRPNAASCLKSIYVDIMCCLEGSPVWFIVSDRNPKYISWEWSSGNKGLRNRVEEVLEAARSSETLRPSSVIFFFSKGLEDVVYEKLQHEFGAADLRLTFPCFDCSFCEGSEDDWIDVLLRSYEEACVLKLEIKDQSNYQNLTSTTGCIIRQTLRDLPLPEENIQGTPTLGESLCSLISGLKCCLLDMELNLLETMCNGQSLQLVNFDTTALIAIVSGISSGGMNKLLATSESKLRSQFKSNYEFVIAQVNSEIRNPIHKELSASTSGKGGIICESVHSEFQELVSMCGGPNEKIRANYILKHLRMVPDCPSSRLASLPTTRKLALKNKVVFGTGDYWHAPTLSANMAFVRAVSQTGMSLFTIQHRPRALIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJN1</accession>
    <name>A0A068VJN1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_759</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00005949001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739843">
        <property type="protein sequence ID" value="CDP19883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJN1"/>
    <dbReference type="STRING" id="49390.A0A068VJN1"/>
    <dbReference type="Gramene" id="CDP19883">
        <property type="protein sequence ID" value="CDP19883"/>
        <property type="gene ID" value="GSCOC_T00005949001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJN1"/>
    <dbReference type="OMA" id="KARYNDQ"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJN1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019762">
        <property type="term" value="P:glucosinolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF318">
        <property type="entry name" value="BETA-GLUCOSIDASE 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="142" mass="16558" checksum="6C99AC9158266640" modified="2014-10-01" version="1">MRILVRDRLPKFTPKQSKELIGSYDFLGLNYYTANYAAHITTPPNKVNLSYSTDQRVNRTASRNGKLIGAQAGSTWLHIYPKGIWDLLLYVKTKYKDPIIYITENGVDEVNNPTLPLKQALQDSFRIRYYYQHLQYVRKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJW6</accession>
    <name>A0A068VJW6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00010619001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DESIGUAL family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741000">
        <property type="protein sequence ID" value="CDP20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJW6"/>
    <dbReference type="FunCoup" id="A0A068VJW6">
        <property type="interactions" value="1479"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJW6"/>
    <dbReference type="Gramene" id="CDP20874">
        <property type="protein sequence ID" value="CDP20874"/>
        <property type="gene ID" value="GSCOC_T00010619001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJW6"/>
    <dbReference type="OMA" id="AIFFPYS"/>
    <dbReference type="OrthoDB" id="1931917at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJW6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009606">
        <property type="entry name" value="DEAL/Modifying_wall_lignin1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052222">
        <property type="entry name" value="DESIGUAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31769">
        <property type="entry name" value="OS07G0462200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06749">
        <property type="entry name" value="DUF1218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655893" evidence="8">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="199" mass="21350" checksum="D19E9E1B1CC79A02" modified="2014-10-01" version="1">MAVTMKQMSLIIATLGALSFIFGVVAENKKPASGTAVTVKDIVICNYPKDPTVALGICSIVFLVAASVAGYLSLFYPYRGKSVPQAALFRNTGFSVFFNIALGLTGLALAMLLWPTITEQLHLSHKVHHNLQTDCPTAKTGLLGGGAFLSLDSALFWLVSLMLADNAREDYFDEADVKGERVTSQGDDYEPDNLVKGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VK01</accession>
    <name>A0A068VK01_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00007863001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DH200</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741106">
        <property type="protein sequence ID" value="CDP20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VK01"/>
    <dbReference type="FunCoup" id="A0A068VK01">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VK01"/>
    <dbReference type="Gramene" id="CDP20914">
        <property type="protein sequence ID" value="CDP20914"/>
        <property type="gene ID" value="GSCOC_T00007863001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VK01"/>
    <dbReference type="OMA" id="DWKEWTS"/>
    <dbReference type="OrthoDB" id="1924990at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VK01"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039349">
        <property type="entry name" value="PRIN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35987:SF2">
        <property type="entry name" value="PROTEIN PLASTID REDOX INSENSITIVE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35987">
        <property type="entry name" value="PROTEIN PLASTID REDOX INSENSITIVE 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="184" mass="20550" checksum="70668817280C11AC" modified="2014-10-01" version="1">MASATSLYSSTSLLPFSSSDSSSSYYVPRPLSISANRIPISCLHDYSNATYFKHLIRKPLFSNSRNPRVTCRAAEYKFPDPIPEFAEAETEKFRAHLLNKLSKKDIFGDSVQEVVGICTEILSTFLHTEYGGPGTLLVIPFMDMADTLNERGLPGGPQAARAAVKWAQNHVDKDWKEWTSKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLI8</accession>
    <name>A0A068VLI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00010594001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="HG743468">
        <property type="protein sequence ID" value="CDP21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLI8"/>
    <dbReference type="STRING" id="49390.A0A068VLI8"/>
    <dbReference type="Gramene" id="CDP21474">
        <property type="protein sequence ID" value="CDP21474"/>
        <property type="gene ID" value="GSCOC_T00010594001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLI8"/>
    <dbReference type="OMA" id="EICNEVY"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF17">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="71"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="386" mass="44424" checksum="3111F89B0E595342" modified="2014-10-01" version="1">MADKDSASGANNENPDRNSDENPVSSYKASLENLVQRFQNSNPFDQKHKFWETQPVGQFKDVGNSSLPEGPIELPTPSSEVKQEPYNLPNSYEWSTCDMGSDEVCNEVYVLLTNNYVEDDDNMFRFNYSKEFLRWALRSPGYYSSWHVGVRVKASKKLKLRSKRLAPVMIKEVTRRIHLENVWQAAYTAGVLLPTPLTTSQYWHRTLNPKKLIDVGFSRLGERMTMSRAIKLYKLPTSTSTPGLRKMELRDVPSVTQLLRNYLSRFSVAPEFDDNESQVTHEITDFFSFYTLPSSILHSQEYSILKAAYTFYYVSTNTPLLQLMNDALIIAKQEDFDVFNALDVMENESFLKELKFGQGDGQLYYYLYNYRLNQALKPSGLGLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMK4</accession>
    <name>A0A068VMK4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_7095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00009492001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG746179">
        <property type="protein sequence ID" value="CDP21847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMK4"/>
    <dbReference type="FunCoup" id="A0A068VMK4">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VMK4"/>
    <dbReference type="Gramene" id="CDP21847">
        <property type="protein sequence ID" value="CDP21847"/>
        <property type="gene ID" value="GSCOC_T00009492001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMK4"/>
    <dbReference type="OMA" id="CHERPHQ"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044552">
        <property type="entry name" value="GLIP1-5/GLL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966:SF1">
        <property type="entry name" value="GDSL ESTERASE_LIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP21847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="376" mass="41763" checksum="BA2E85279287A467" modified="2014-10-01" version="1">MAKEYRIGLNLANSYIQLCLIVVLVVLASLTIPSDCFQHDDQYPKTIAGLFVFGDSLIDPGNNNYINTSRDVQANFPPYGVSFFKYPSGRFCDGRVIPDFIAEYAKLPFIPPYLQIGYRYQLAYGANFASGGAGALVEPFSGLVIDLKKQLWYFNQAEKQLRSNLGKRGAERIVSNSVYLFSIGANDYSSDRRKDYVATVVGNITAALEEIYKKGGRKFGVVNMPPIGCLPLFRAADLAAGGTGECNGQLTALAKLHNVLLSKKLEHLQKQLKGFRYSYFDIFTAAVEMFDNPSKYGFKEVKSACCGSGPFRGDRSCGGRGGFKEYELCDNPQDYFFFDSNHPTQAANQQLAELMWAGPSDITWPHNLKSLFRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMW2</accession>
    <name>A0A068VMW2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_8145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00010960001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG747229">
        <property type="protein sequence ID" value="CDP21949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMW2"/>
    <dbReference type="Gramene" id="CDP21949">
        <property type="protein sequence ID" value="CDP21949"/>
        <property type="gene ID" value="GSCOC_T00010960001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMW2"/>
    <dbReference type="OMA" id="YFRIRRC"/>
    <dbReference type="PhylomeDB" id="A0A068VMW2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF42">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="583" mass="65617" checksum="6CD6C851200E041D" modified="2014-10-01" version="1" fragment="single">GGISTDMNMLLRFKCLNVLRLSGYDVESLPSSIGKLLHLRLLDISSSGITSLPESLCKLYNLQTLTMRDGELEGGFPKRMSDLISLRHLNYYHGGAELKMLMQMGRLTCLQTLEFFNVSQKRGCGIEELGTLKYLKGSLSIRNLGLVKGKEAAKQAKLFEKPDLSYLAFRWESGDRESDNREEDVLEGLQPHPNLQGLKIYYFMGNKFPQWLINLSKLETLRIQKCKRCSELPSLGQLPSLKILYLIGLDNIRFIGDEFYGSSTRRRKFFPALEVLCVEYMGNLAEWKGADQVRSTVGEAEADVFPMLRYFRIRRCPQLTTLPCSCKSLDVESCDNLTSIKMGYGTASVEALSIDSCDNLKELPDLDLFGSSLQRLTILFCPRLISLGVNGQKCPLPCLEELIIHNCEGLTTISDKMFQSCRSLRSLSVRWCRNLVSFSLNLQETPSLERFILKECPKLIPHRFNGFAFATSLKELSINSPFSSDDSSVDDFDWPGLENASTLRKLRLEGLPHTESLPHQLQCLTTLTSLSLHNFGGIEVLPDWIGNLVSLETLQLSNCENLRSLPLTKLTCVEVDDCPLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNL6</accession>
    <name>A0A068VNL6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00007327001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG750844">
        <property type="protein sequence ID" value="CDP22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNL6"/>
    <dbReference type="STRING" id="49390.A0A068VNL6"/>
    <dbReference type="Gramene" id="CDP22187">
        <property type="protein sequence ID" value="CDP22187"/>
        <property type="gene ID" value="GSCOC_T00007327001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNL6"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNL6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF117">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="2">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="135" mass="15022" checksum="B8EDE749516D67A3" modified="2014-10-01" version="1">MKVDPDVDLRQIAADTELFTGAELEGLCKEAGIVALREDISATLVCSQHFQTVRNSLKPALTREDINFYSSFMKNLLLRSSAPSKPKSNHRVKETKKLFILTIPITLGVIGFMLYGGMKYFLTSLDRVPKVLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNU5</accession>
    <name>A0A068VNU5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_13224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00006251001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG752308">
        <property type="protein sequence ID" value="CDP22272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNU5"/>
    <dbReference type="STRING" id="49390.A0A068VNU5"/>
    <dbReference type="Gramene" id="CDP22272">
        <property type="protein sequence ID" value="CDP22272"/>
        <property type="gene ID" value="GSCOC_T00006251001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNU5"/>
    <dbReference type="OMA" id="ENACYSG"/>
    <dbReference type="OrthoDB" id="1572689at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040361">
        <property type="entry name" value="TPD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33184">
        <property type="entry name" value="PROTEIN TAPETUM DETERMINANT 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33184:SF61">
        <property type="entry name" value="TPD1 PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24068">
        <property type="entry name" value="TPD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001659039" evidence="3">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP22272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="22350" checksum="7478FC81503EAFD4" modified="2014-10-01" version="1">MKIAVDRCRSAKCKACMALGFACMLLPLLFAVDHYQASESVIETCNGIQEQAFSEENKASSTARKLLAFSGNGTGEDIGDAGDDDGYGGDGDSDSGGDGGLADRIGGQGPSCSKDNILVFQGQTKRMFNGIPTYTVEVQNVCDSASCSISNIHLSCGWFSSARLINPQIFRRLGYNDCLVKDGQALNPGESLTFQYANSFSYPLSVSSVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TKQ3</accession>
    <name>A0A068TKQ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014062001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TKQ3"/>
    <dbReference type="STRING" id="49390.A0A068TKQ3"/>
    <dbReference type="Gramene" id="CDO96890">
        <property type="protein sequence ID" value="CDO96890"/>
        <property type="gene ID" value="GSCOC_T00014062001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TKQ3"/>
    <dbReference type="OMA" id="SSRLEYX"/>
    <dbReference type="OrthoDB" id="1741752at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TKQ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF78">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO96890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11435" checksum="4C07285E7CFDAB1C" modified="2014-10-01" version="1">MYRAINNLPGGKTDVSFPDIHNMVSLYFLTLRNCSLTGPIPDYIWRFTNLFYLDLSFNNLTGKIPPDLNQSQPQFVFLRSNKLNGTVPGWLTSLSNSGSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP43</accession>
    <name>A0A068TP43_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021996001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP43"/>
    <dbReference type="STRING" id="49390.A0A068TP43"/>
    <dbReference type="Gramene" id="CDO98026">
        <property type="protein sequence ID" value="CDO98026"/>
        <property type="gene ID" value="GSCOC_T00021996001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP43"/>
    <dbReference type="OMA" id="CCYSEVT"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF278">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE A HPR2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="2">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="204" mass="23397" checksum="C91E4468A8CEE697" modified="2014-10-01" version="1">MDSNSIGVLMTCPMSPPYLEQELDRRYRLLRFWKFPQKTELLKPHSQEIRAVVGNATIGANAELIDALPKLEIVSSYSVGLDKIDLAKCKDRGIKVTYTPDLITDDAADLGIALILAVLRKICGCDLFVRRGLWKNGDFQLTSKPMTFVLFRPFVFSGRPFRFILDHKSADRKVKRYCCYSEVTYYQLFEFLTFVNHLTISTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPL3</accession>
    <name>A0A068TPL3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00014610001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPL3"/>
    <dbReference type="FunCoup" id="A0A068TPL3">
        <property type="interactions" value="1976"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPL3"/>
    <dbReference type="Gramene" id="CDO97303">
        <property type="protein sequence ID" value="CDO97303"/>
        <property type="gene ID" value="GSCOC_T00014610001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPL3"/>
    <dbReference type="OMA" id="QRPNLPH"/>
    <dbReference type="OrthoDB" id="101791at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPL3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd22165">
        <property type="entry name" value="F-box_AtSKIP22-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47602">
        <property type="entry name" value="F-BOX PROTEIN SKIP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47602:SF2">
        <property type="entry name" value="F-BOX PROTEIN SKIP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="385"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="530" mass="58993" checksum="30225913E1F118F8" modified="2014-10-01" version="1">MKLRIRSFGTKETLRIEVPIPCSLQQLKDIISQTLRPSTSSSPLAPSDSIHLSLNRKEEIQSSSPNEDTLQSLGITSGDLIFYTLDPSRFSSSESLIPNSQEPISSPLVQNYEIPLRIDLTLDSGKPLQKPSSMEPLDPPKNTNSDPSSQLKQAHQPGSANLNEQNEGSTDYMEFDGIDDQEEGNDASALEAVGNGKSFSVPGFLRKVFTEELGGGDDDGSRSHKLLVIAIHAVLLESGFVGFDMNLKTESKGFPFRNDWPSSGFRLSLFYTLPEIVRDVSPSLDCHNCVVGLKFQNVGKFMMVYGSLNAGSAMHSVRLNEDELGSFLNVVWANCGLGDDIMISGDVVLGASPENEVFKFWRNVKDNLALPLLIDLCETVGLVLPPCFMRLPTDLKLKILESLPGVDIAKVSCVSAELRYLASSDDLWKQKCVEQFGHACKTEDKGHWKEKFARFWESRKRRKLASRSLFRRPLHPRRILDPIPRFPHWPGIIGGDYDLYPQIPGGARLRDPGYCSRSHVPRCQFGRNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ00</accession>
    <name>A0A068TQ00_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014789001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ00"/>
    <dbReference type="FunCoup" id="A0A068TQ00">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ00"/>
    <dbReference type="Gramene" id="CDO97443">
        <property type="protein sequence ID" value="CDO97443"/>
        <property type="gene ID" value="GSCOC_T00014789001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ00"/>
    <dbReference type="OMA" id="WKRTHEP"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ00"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000004">
        <property type="entry name" value="Outer envelope protein 64, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF4">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 64, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="337"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="601" mass="65708" checksum="6A234AB97FBAFB4F" modified="2014-10-01" version="1">MSSSSKLNVSNPKVWILIGVGVAGIIVLAETRRRRLKSRNAIKEDFGSFVERFELSPFPQPPPPAARLPLSGLTFAIKDIIDVKGFVTGFGSVDWKKTHEVAAKTAVVVTALLQSGATCVGKTIMDEFGFGITGENSHYGTPTNPNLPSHIPGGSSSGSAVAVAAKLVDFAIGTDTIGCIRIPASFCGILGFRPSHGIVSLVGVLPNSQSLDTVGWFARDPSTLRHVGHVLLQLNPLETRKTRRLLIADDLFQLSKVPKWKTIDVFKRVTGKLSGYQTANHIKFGQYISSNVPSLKGFHEELKNQTLISNVKALASVMSILQRYEFRTNHEEWFVSVKPRLGPRVSDGVLAAINTTPENIKILYKIRSEMRTALQALLKDDGILVIPTVADPPLKLNIKKGAFSEFLDRTFALSSIASMSGCCQVSVPFGEHDDYPVSVSFIASHGADKFLLDTIVDMYSSLQDEVSTVSNSPPLPDINGNMETSELLKEKGNAAYKGKQWNKAVSYYTEAIGLNDKIATYYCNRAAAFLELGCFQQAEEDCTSAISLDKKNVKAYLRRGTARESLLCYKEALLDFKHALVLEPQNKAANLAEKRLRKLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ02</accession>
    <name>A0A068TQ02_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00022372001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ02"/>
    <dbReference type="FunCoup" id="A0A068TQ02">
        <property type="interactions" value="1179"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ02"/>
    <dbReference type="MEROPS" id="M16.004"/>
    <dbReference type="Gramene" id="CDO98316">
        <property type="protein sequence ID" value="CDO98316"/>
        <property type="gene ID" value="GSCOC_T00022372001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ02"/>
    <dbReference type="OMA" id="ENVEIHC"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ02"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000025">
        <property type="entry name" value="Stromal processing peptidase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000040">
        <property type="entry name" value="Stromal processing peptidase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF33">
        <property type="entry name" value="STROMAL PROCESSING PEPTIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="219"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="363"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="932"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO98316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142656" checksum="730EC2531C651DC1" modified="2014-10-01" version="1">MQTNSAIFNAKPVLFAPVPIIKSVNTTDHNPSSSLASSPSSLLFPAHNQNWAHRKKATITSRSDKHRWSRTHLISPKNAFKRFPCAPTSLLDGSKCISCFHYPHQKRVGGHRFRTGAFFDKSASHILKQNVDNSLSGKVKQLNVPRATLGPEEPHAASTTWPDGVLEKQGLDLYDPELERSEFERFLSSELPSHPKLHRGQLRNGLRYLILPNKVPPSRFEAHMEVHVGSIDEEEDEQGIAHMIEHVAFLGSKKREKLLGTGARSNAYTDFHHTVFHIHSPTRTKDSDDELLPVVLDALNEIAFHPKFLASRVEKERRAILSELQMMNTIEYRVDCQLLQYLHSENKLSKRFPIGLEEQIKKWDADKIRKFHERWYFPANATLYVVGDIDNIPKTVQHIESVFGQTGVESETVVPPTPSTFGAMASLLVPKLTVGLAGSLAHDKSSGSVEQSKIFRRERHAVRPPVQHNWSLPGSNDALKPPQIFQHELLQNFSINMFCKIPVNKVQSFGDLRNVLMKRIFLSALHFRINTRYKSSNPPFTSVELDHSDSGREGCTVTTLTVTAEPKNWQSAIKVAVQEVRRLKKFGVTKGELARYLDALLKDSEQLAAMIDNVSSVDNLDFIMESDALGHRVMDQRQGHESLVAVAGTITLEEVNAVGAKVLEFISDFGKPSAPLPAAIVACVPMKVHMDGLGETDFKIIPTEITAAIEAGLKEPVEAEPELEVPKELITTKQLQELMLLRRPSFLSVGPDVNQTKVYDAETGIMQRRLSNGIPVNYKISKSEAKCGVMRLIVGGGRAAEHLEKKGAVIVGVRTLSEGGRVGSFSREQVELFCVNHLINCSLESTEEFICMEFRFTLRDNGMRAAFQLLHMVLEHSVWLDDAFDRARQLYLSYYRSIPKSLERSTAHKLMLAMLNGDERFVEPTPHSLQNLTLECVQDAVMSQFVCDNMEVSIVGDFSEDEIESCILDYLGTVEATKGLERAQSYRPITFRPPAADLQHQQVFLKDTDERACAYIAGPAPNRWGFTFEGQDLFEAIDDGIPTREGANEQLKLEDQLMVSQRSGEDLQQGFRRHPLFFAITMGILAEVINSRLFTTVRDSLGLTYDVSFELNLFDRLNLGWYVISVTSTPGKVHKAVDACKNVLRGLHTNRITPRELDRAKRTLLMRHEAEIKSNAYWLGLLAHLQATSVPRKDITCIKDLTSFYETANIEDIYLAYEQLKIDENSLFSCIGVAGTQAGEGVSDPLQEEDSVEGLQTVIPLGRGSSTMTRPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ10</accession>
    <name>A0A068TQ10_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022486001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ10"/>
    <dbReference type="FunCoup" id="A0A068TQ10">
        <property type="interactions" value="1625"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ10"/>
    <dbReference type="Gramene" id="CDO98405">
        <property type="protein sequence ID" value="CDO98405"/>
        <property type="gene ID" value="GSCOC_T00022486001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ10"/>
    <dbReference type="OMA" id="QDEYFNM"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ10"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000055">
        <property type="entry name" value="Ribosomal protein S24/S35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="301"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="415" mass="48428" checksum="D3D4D18326EF448F" modified="2014-10-01" version="1">MRRALSLCLRNLHQSPHLKLYPNNLNHPKKLRFFSSSSETGNDSSNQTTPDPNPTPQPKTKLDQPEEKELALEDVDNKELKLRIDDYFKKGNEEALPSIFEAILQRRLTGKHEETDDEVISELQMQPLDDVKDQDFESDFEEVYETDEEIEDLYNARDIVTKRMVQDEYFNMDDRKWDDMVREATEKGYLKDTKECEEILEDMLNWDKLLPDEIKQKVEKKFDEIAARVENGELEVEEGYALFKEYEDQMVMECAKLMEAEAPHFDDSTVPDKKKDLDDPPGEGPILRWQTRAVFAPGGDAWHPKNRKVKLAVTVKELGLSKHQFRRLRELVGKRYHPGKDELTITSERFEHREENRKDCLRTLLSLIEEAGKANKLVDDARTSYLKERLRSNPHFMGRLNAKITRKGELSLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ80</accession>
    <name>A0A068TQ80_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein NPG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022493001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ80"/>
    <dbReference type="FunCoup" id="A0A068TQ80">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ80"/>
    <dbReference type="Gramene" id="CDO98411">
        <property type="protein sequence ID" value="CDO98411"/>
        <property type="gene ID" value="GSCOC_T00022493001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ80"/>
    <dbReference type="OMA" id="NEFDIWH"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ80"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043376">
        <property type="entry name" value="NPG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44102">
        <property type="entry name" value="PROTEIN NPG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44102:SF5">
        <property type="entry name" value="PROTEIN NPG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="78251" checksum="BB52D6A60F9D5B7E" modified="2014-10-01" version="1">MSEGESEEFGQLEIDASVRQVCANGICMQTTVVEAKLDEGNIQEAESALREGLSLNFEEARALLGRLEYQRGNVEGALRVFDGIDLQAAIQRMQPQAEKPPSKKGRSRSDSVHAGSQHAASLVLEAVYLKAKSLQKLGRVNEAAQECKSVLDAVEKIFCDGIPDVLVDSKLQETVSHAVELLPELWKQAGSNSEAMSAYRRALLSQWNLDNDCCARIQKAFAVFLLYSGVEFGPPSLAVQIDGSYVPRNNLEEAILLFMILMRKFYIGKIKWDPSIIEHLTFALSLCGQTSVLAKQLEEVMPGVIHRTDRWKTLALCHSGAGQNDTALNLLRKSLHKHEDPDDIFSLLLAAKICSEDTFLAAEGVEYAQRAIANSSGLNEHLKGVGFRVLGLCLGKQAKVSSSDFERSRLQSEALRSLASATALEKENTDLILELGVQYAEHRNLNAALRYARRYIDATGGSVLGGWRLLALVLSAQQRYSEAVVVIDAALDETAKWDQGPLLRMKAKLQISQSLHTDAIETYRYLLALVQAQRKSYGPLRVFPQVEDDKVNEYDVWHGLANLYSSLSHWKDAEICLGKARALVEFSADTNFYILSFVTVSGLMLERRGELHEALSAYTNALLLEPSYVPCKILLGSLLCKMGLKMLPLARTLLSDALRIEPTNRTAWYHLGLVHRDDGRMADAVDCFQAASMLEESDPVESFTSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR18</accession>
    <name>A0A068TR18_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00022593001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR18"/>
    <dbReference type="STRING" id="49390.A0A068TR18"/>
    <dbReference type="Gramene" id="CDO98482">
        <property type="protein sequence ID" value="CDO98482"/>
        <property type="gene ID" value="GSCOC_T00022593001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR18"/>
    <dbReference type="OMA" id="HNHRNTG"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR18"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF14">
        <property type="entry name" value="PROTEIN DECAPPING 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="2">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO98482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="718" mass="78459" checksum="B364B4A047ADCBB4" modified="2014-10-01" version="1">MAAPGASSVAPMVTDKGKKVETETTDAARGVEAYIGSLISLITKSDIRYEGFLFHLSPQESIIGLRNVKSFGTERQKMDGTQVAPSDRLYEYIYFRGTDIKDLQVISFPHVQSTPTLPDDPAIIQPHHSNPPSTNISLASSSALVGSNPSSNSHLGVNVLPPEGNTAPRRSMELSDSWASVIPLPPVNINGPSMQSYWPGFTGFPGEKSHLQQITYPPQPQGLLLPNSIQQQLPHPSVNASFPGNALNFIELPQNLLPPACFGSVNLISTSPLPSTVQYSHIPLSTLLSNLSSTPMSSNISNALPTDQPLSMEVVDSGSEKEPSLVIASNVNSAVPPSNNQAQSLLGPAPFPLISKFTSSFVSSSTTPHVRGSNVSPAIPGSFWERRPVNALSPHNCTDGNSNLGSPSNHQPSDLQNIEELAIELPKSPARKLYDPASSSHPGSQHHGQVQGRGRGDLVHFMPFLIDFPFHRECCILQLEGFSYISFCAFSLVQIYGDMHLRYQSNRDRMLGRGRGNLPNRAFSHNYQTCRVFCSYSTYHNQMFFGCLIFQLIGTASYRHQAPRGQGRANAADANFTEDFDFEAMNAKFNKKEIWGLLDKAKQGGSEDNKEDEIGRKGKEAVDESGNGLPKLDNKSAYYKDDFFDSLSCPTLDGESYRGKVSELRKTDDEKIGEILQHRRDHGIQGPYRGGNSQGSYRGRGYYNAGRGRAKAAWSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSM7</accession>
    <name>A0A068TSM7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00026387001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSM7"/>
    <dbReference type="STRING" id="49390.A0A068TSM7"/>
    <dbReference type="Gramene" id="CDO99290">
        <property type="protein sequence ID" value="CDO99290"/>
        <property type="gene ID" value="GSCOC_T00026387001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSM7"/>
    <dbReference type="OMA" id="CEEKCFL"/>
    <dbReference type="OrthoDB" id="1917524at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSM7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1228">
        <property type="entry name" value="NB-ARC DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="178"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="441"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="587"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO99290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="925" mass="105392" checksum="FD0C9804FE22BD20" modified="2014-10-01" version="1">MTSLVNMLSATRGRLQYLAYERGSPLAVDKLDLSSYCEALQNIVDALKFVRSKTETERQSERILEVKRRIRSLLFTMEDEVELYGLQHESGGSGSGDIHSRRMQGITKSRAKLDIIHSQLRDAVVEYKREQAPDLLMGFHDIKSIDDIRGASRTREKAERLVSRANYSNDWEHTVGLEKAISRLVEVLVPGDTDAKVVIASICGEGGIGKTTLANKVYNQHQIRSHFECFAWVYVGINWTIRDILVNILDQLLPSRLTKKNKELMMMTMVDVEDVELAQQVHEVLQENVCLIVLDNCCTYEFWDSLRMALPTEEENASRFILTTRERDLADRVGAGFIWDMQNLDPDQSWELGSADRLPNSRRDSVSPELEQNIRSLISSCRGLPLAIVLVASMLRSRTIDMESVKVSLGIINSSRRRPESLSYYSLPLGISSSFLYLGNFPNNSGIQVDKLCQLWTAEGLISAYREDGETTMDLAGRYFDELLVRSLVILHEDEVSDVKLMSCHVHDLIRDFSVSLGEEEGFYEVMESSSNHPRMRSSAQRCAIYLNRYDNLADVCPSANLRSLLILNSDQSGSGQEHTWRQEFFNFNNHRWLRVLDFDKVCFQDGKLPDGVSKLFFLRYLSFRGSYLKDLPSFVGEFLYLETLDLRVRNDCTLTISNVIWKLKLLRHLYFPLAFQTPDHCGMLKLDGLNELETLEGLDTNVCCAEDLIKLTNLRSLAIINCIKNNSSHLSRTLLDIKNFDCYSEERVSFIPSLFSCGVLKSLRMEGHMGKVPEVSTISSSFTEIVLSGSEFERDPMENLEKLPNLRILVLEIEAFVGKNMNCSAPGFPELRCLKLSKLYSLEAWEVAEGAMHQLFTLEISKCRRMEMLPEGLKYISSLRKLKISMMPEQFVGRLHKVDGKGGEDLHKINSNCTIKFGSDDRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSN4</accession>
    <name>A0A068TSN4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00022430001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSN4"/>
    <dbReference type="FunCoup" id="A0A068TSN4">
        <property type="interactions" value="1588"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSN4"/>
    <dbReference type="Gramene" id="CDO98363">
        <property type="protein sequence ID" value="CDO98363"/>
        <property type="gene ID" value="GSCOC_T00022430001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSN4"/>
    <dbReference type="OMA" id="QWEEITI"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSN4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF146">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIS8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="758"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO98363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="932" mass="101780" checksum="DC056F1FF75E0DB1" modified="2014-10-01" version="1">MKNFLKKLHIGSNQPEDSEGSTSSSKWNRLSDVSSPERFSHSRSQHTSEHNKPFSAISGWLNSVTHRKSPSPPSSSNVPGVDNMEPSDSLGSSGIDASLEAMRRDSGSSNSRDPDIEEEYQIQLALELSAREDPEAVQIEAVKQISLGSLPPDNTRAEVVAYQYWNYNALSYDDNILDGFYDLYGIFTEFSSSKMPSLIDLQGTPVSDSITWEAILVSKANDTKLLKLEQEALEMAVKSRLGSVIFVGHNLLRKLAIIVSDYMGGPVGDPEKMSMAWRSLSYELKATLGSMVLPLGSLTIGLARHRALLFKVLADCLGIPCRLVKGQQYTGSHDAAINFVKIDDGREYIVDLMGDPGTLIPADITAANTEYEEAFPSANDFLKDDNSHFASSSALVPNLLQDHSEVESRFADSSAATVESNSEGECLAFQNLPQIKVEEGSNKSAEDIPKPNGVRKLIPDVRSRPNPPYSHARSPSWTEGVSSPAVHKMKVKDVSQYMIDAAQENPHLAQKLHDVLLESGVVAPPSLFTEIYPKQFNNVPVDSKSLKGDGENEEKGNTKRILGQDNVSWARFLPPLPYHGLCSKGIPRDQVEHQIDFREGTGQHVPSQPEVTPAIYTKNVPVAAAAAAAAAVVASSMVVAVAKTGTDANLELPVTAAATATAAAVVATTAAVSKQYENLEIGASSPDSPAAFFNPFGCAKSDEDADAAAYNQRGSGSREQEALGDGERTSDRSTGNDSAKSDAMLDDVADCEIPWEDMALGERIGLGSYGEVYHGDWHGTEVAVKRFLDQDIAGESLEEFKSEVWIMKRLRHPNVVLFMGAVTRPPNLSIVTEFLPRGSLYRLLHRPNNQLDERRRLRMALDAARGMNYLHNCTPVIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKHSTFLSSRSTAGTVSRCIGFYLLWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSZ0</accession>
    <name>A0A068TSZ0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022563001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSZ0"/>
    <dbReference type="FunCoup" id="A0A068TSZ0">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98463">
        <property type="protein sequence ID" value="CDO98463"/>
        <property type="gene ID" value="GSCOC_T00022563001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSZ0"/>
    <dbReference type="OMA" id="YKEMWNE"/>
    <dbReference type="OrthoDB" id="1927707at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSZ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7779" checksum="67398CF85B7FA142" modified="2014-10-01" version="1">MRSARWGYFRIITGTIIGGIFGFYVMHLAELKYKEMWNERLKKYEEELNRKKIAEQSNEFQESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTY8</accession>
    <name>A0A068TTY8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029426001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTY8"/>
    <dbReference type="FunCoup" id="A0A068TTY8">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTY8"/>
    <dbReference type="Gramene" id="CDO99745">
        <property type="protein sequence ID" value="CDO99745"/>
        <property type="gene ID" value="GSCOC_T00029426001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTY8"/>
    <dbReference type="OMA" id="ETHCSCF"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTY8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000198">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (NAT) superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47443">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47443:SF3">
        <property type="entry name" value="GCN5-RELATED N-ACETYLTRANSFERASE 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="280" mass="31177" checksum="20273754E9CDC133" modified="2014-10-01" version="1">MPPLTVSGTSSINFNSLSLTQNPSLNHLNFFNSRTSFPSSYRAPLHDPLSPSLLSSSGLCRASQLAELFPTMSPDIVVREARLEDCWEVAETHCSSFFPQYSFPLDFALRIDRLIGMLFGFSLPGGCQRTCLVAVTGQSDEDTLHFWNEDLKIGGFDGKFSLNKGYVAGILTVDTVADFLPRKGPLRQRRKGIAYISNVAVRENFRRKGIAKRLINKAETQARSWGCRAIALHCDLNNPGAIKLYKGQGFKCVRVPEAANWPQPKTSPDGQFHFMMKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUV6</accession>
    <name>A0A068TUV6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chlorophyllase</fullName>
            <ecNumber evidence="4">3.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00026161001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a chlorophyll + H2O = a chlorophyllide + phytol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17327"/>
            <dbReference type="ChEBI" id="CHEBI:139291"/>
            <dbReference type="ChEBI" id="CHEBI:139292"/>
            <dbReference type="EC" id="3.1.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19606"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; chlorophyll degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUV6"/>
    <dbReference type="STRING" id="49390.A0A068TUV6"/>
    <dbReference type="ESTHER" id="cofca-a0a068tuv6">
        <property type="family name" value="Chlorophyllase_Plant"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO99123">
        <property type="protein sequence ID" value="CDO99123"/>
        <property type="gene ID" value="GSCOC_T00026161001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUV6"/>
    <dbReference type="OrthoDB" id="2093222at2759"/>
    <dbReference type="UniPathway" id="UPA00674"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047746">
        <property type="term" value="F:chlorophyllase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015996">
        <property type="term" value="P:chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000159">
        <property type="entry name" value="Chlorophyllase-2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017395">
        <property type="entry name" value="Chlorophyllase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428:SF2">
        <property type="entry name" value="CHLOROPHYLLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428">
        <property type="entry name" value="CHLOROPHYLLASE-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07224">
        <property type="entry name" value="Chlorophyllase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0881">Chlorophyll catabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-type ATPase A" evidence="9">
        <location>
            <begin position="202"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO99123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="679" mass="73744" checksum="E992682AC4F8F0E0" modified="2014-10-01" version="1">MSAMTRAKLGCRIFSVHLPPNLGGYDIKIRDSCLVSVHFSRGFKGVHTSIKSITCLIPSQSTAKNWKENSAVATDDRVVMDIVQDLPCFTIDQSSLMHIVEMRSLDQLHKFGGVHGIANSLNSDVHRGIDSDDNAGISRRHEAFGTNTYSEAAGKNFYGLMEGLYGGGSIFSAVLVVLSIVASTDFRKNRNYSENFMVSDSSPVEVMRNGKLKHISTSEVAVGDVICLKIGDQVPADGLLIEGPALRVDESSMTTTGSFHDHEIKHHDQNPFLFSGTKVTVGCARMLVTSVGMNTTRGKMLSSMSSESIEHTPLKSQISRLISSIGEVGSGAAVVAFVLNLIQTKRNYNLERRKKKLKELAMVFTASSAVASSISRNVFGVGKYISKLLKVEQQTSIGNALLGIARPPKPLLIGIPSEAGVFPVLLFIHGYLLYNSFYSQLVQHIASHGFIVIAPQLYSMAGPDTTEEINATAEIANWLSEGLQKLLPPKVQANLSKLALAGHSRGGKVAFGVALGKAVTSLKFSALIGIDPVDGVEKGKQMPPILTYNPHSFNLDMAVSIIGSGLGELRSNFLFPPSAPKGVNHKDFYNECQKPACYFVARDYGHLDMLDDDTSGLRGKATYCLCKNGESRDPMRRFVGGIMVAFMRNYLEGNSRDLQAIRHGHLTAPVELQNVDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUY6</accession>
    <name>A0A068TUY6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00029845001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUY6"/>
    <dbReference type="FunCoup" id="A0A068TUY6">
        <property type="interactions" value="2194"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TUY6"/>
    <dbReference type="Gramene" id="CDP00066">
        <property type="protein sequence ID" value="CDP00066"/>
        <property type="gene ID" value="GSCOC_T00029845001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUY6"/>
    <dbReference type="OMA" id="NMFLPDR"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUY6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000028">
        <property type="entry name" value="Methionine--tRNA ligase, chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008900">
        <property type="entry name" value="PRK12267.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="218"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="461"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP00066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="625" mass="69208" checksum="994AD66DE915D27B" modified="2014-10-01" version="1">MASRVQNPIQNRLWLLSFSTSSTSSLCNSVSLKKTRFTNRSLFGKRMPWSSSRRNLYCTCSTSRGSTMDSNTSPSSGRQNAEPFVITTPLYYVNAPPHMGSAYTTVAADAIARFQRLLGNKVVFITGTDEHGEKIATAAAACGCSPAEHCNVVSQAYRTLWRDLGIAYDKFIRTTDHKHEAIVKEFYSKVLANGDIYRADYEGLYCVNCEEYKEEKELLDNNCCPIHLKPCVAKKEDNYFFALSKYEGFLGKMLSENPEFVQPSFRLNEVQSWITSGLRDFSISRASVDWGIEVPNDAKQTIYVWFDALVGYISALLNDGEQPNLQTAISSGWPTSLHLIGKDILRFHAVYWPAMLMSAGLQLPKMVFGHGFLTKDGNKMGKSLGNTLEPTDLVQRFGPDAVRYFFLKEVEFGSDGDYSESRFINTVNAHLANTIGNLLNRTLGLLKKNCRSTLAVDSAIAAEGNTFKDAVEMLVTKAKTHYETLALSSACEAVLEIGNAGNLYMNQQAPWSLFKQGGAASETAAKELVIVLEAMRIIAIVLSPVTPSLCLRIYNQLGYTEDQFDTITWSDAKWGGLKAGQVMAQPKPVFSRIENQIEDGNAGETVKAGSKDKENINQNKSAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX07</accession>
    <name>A0A068TX07_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00029610001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX07"/>
    <dbReference type="FunCoup" id="A0A068TX07">
        <property type="interactions" value="3535"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TX07"/>
    <dbReference type="Gramene" id="CDO99898">
        <property type="protein sequence ID" value="CDO99898"/>
        <property type="gene ID" value="GSCOC_T00029610001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX07"/>
    <dbReference type="OMA" id="HIRAKSM"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX07"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO99898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="251" mass="27142" checksum="E3E23991F253525F" modified="2014-10-01" version="1">MAKDFNVPPVVFPSGGNPGAGIGPGAQQRRPSAPFQPPRSANPNIPFMSFDVSSAPSSTAFSTPQFAPTTIGGGGTGFEDEAPLLEELGINTKQIYQKTISILNPFRVRADLHDDADLSGPFLFLMAFGLFQLLAGKLHFGIILGWVTVAALFLYVVFNMLAGRNGNLDLYRCLSLIGYCMLPIVISSAISLFVPQGGMLIMVISGFFVIWSTRVCTRLLVELASYGDEHRGLIAYACFLIYALFSLLVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXB9</accession>
    <name>A0A068TXB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/arginine-rich splicing factor RS2Z32-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00029762001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family. RS2Z subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXB9"/>
    <dbReference type="STRING" id="49390.A0A068TXB9"/>
    <dbReference type="Gramene" id="CDP00008">
        <property type="protein sequence ID" value="CDP00008"/>
        <property type="gene ID" value="GSCOC_T00029762001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXB9"/>
    <dbReference type="OMA" id="HENIWVE"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000272">
        <property type="entry name" value="Serine/arginine-rich splicing factor RS2Z32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000022">
        <property type="entry name" value="Serine/arginine-rich splicing factor RS2Z32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000003">
        <property type="entry name" value="serine/arginine-rich splicing factor RS2Z32-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP00008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33867" checksum="2EF0E60057CF8314" modified="2014-10-01" version="1">MPRYDDRHGVTRLYVGRLSSRTRSRDLEDLFSRYGRVRDVDMKRDYAFVEFSDPRDADDARYSMNGREVDGSRIIVEFAKGVPRGPGGSRDRDYLGKGPAPGTGRCFNCGIDGHWARDCKAGDWKNKCYRCGERGHIERNCQNSPQKLKRGRSYSRSPSPPRRGRSPSRSYSRSRSYSRSRSPPRRDRSNEREEKRSRSPKRHRVSSPPPSKGRKHSPTPDERSPRERGTPSPRDGRPTNDSEYSRSPKDDAPRDDGIKDRSPLEENGRSRSPSPIRRDNGSPADNDETNGSPRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXP7</accession>
    <name>A0A068TXP7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00034596001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXP7"/>
    <dbReference type="Gramene" id="CDP01085">
        <property type="protein sequence ID" value="CDP01085"/>
        <property type="gene ID" value="GSCOC_T00034596001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXP7"/>
    <dbReference type="OMA" id="ITILCES"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXP7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000055">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF774">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 85A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="436" mass="48889" checksum="2605331C26584543" modified="2014-10-01" version="1">MGSIAPLEKKPHAVCVPAAAQGHIGPMLNLAKLLHHNGFHITFVNTEFNHRRLLKSRAIPDGLPPSDVDATQDVPTLCESMDRTCLGPFRELLAELNDTSSSKVPPVSCIVSDAVTAFTLAAAEELSIPEVLFWTASACSYLGYFQYAKLMEKGIIPLKDASYLTNGYLDTVLDWIPELEGIRLKDLPSFLRTTNPDDFMVKFVLQETQRARKASAIIINTYQQLEHGVLDALSSYLPPIYTIGPLHFLDNHVHDKSLTDIQSNLWKEEPECLEWLDSKDPNSVVYVNFGSIAVMTPEQLVEFAWAPDLLIANETFCWCPQEKVLSHPAVGGFLTHSGWNSTIESISYGVPMICWPFFADQQTNCWFCCTKWGIGMEIDNNVKRDDIESLVSELMAGEKGKEMKKKAMDRKKLAEMAVTDSNSNLENLIQFHNRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXS2</accession>
    <name>A0A068TXS2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00034298001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXS2"/>
    <dbReference type="STRING" id="49390.A0A068TXS2"/>
    <dbReference type="Gramene" id="CDP00867">
        <property type="protein sequence ID" value="CDP00867"/>
        <property type="gene ID" value="GSCOC_T00034298001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXS2"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXS2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF47">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="450"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="907" mass="101631" checksum="23F5A3A14CCDC9A5" modified="2014-10-01" version="1">MNFGRNNFSGEIPSWLGALPELELLLLDHNRFTGVLYAISQSRRAATATLNHGSIPSGIFNMTLLEEIDLTNNSLSGNLPTDPCTNNQFKLTDLFLSYNHMQGAIPSELYKCRDLEFLLLGRNQFNGNIPRTLGFLTKLKWLFIGGKIFSGIYWTPFFSATGAFSIQEFSMSSSLLIGQIPLFIFNMSSLKAIDLSRNNLSGSFLLNMWYNLPVLEELYLSTNQPNGPIPSFIWDCKTLVRLYLAENNFTGEFPGEIGKNNNLEILSIINNNLSGLIQPGIFNMSSLVYMHLAFNHFSGSVPSSMQIRLPKLQEIFLDSNKFSGRLPSSITNYSKLTMLVMSQNSFSGPIPSTLGNVRSQLEYVDISGNQFDGLLPPSIGNFSSSLRLFRTFGSRISGTVPSEIGNLSSLEAIYFDDNDLTGFIPSSVGNLSRVQGIYLEHNRLQGHIPTELCQLKNLGDLGVFLQSNCLNSTIPFSFWHLKDLLRLNLSSNSLSGHLPTEIQNLKVITQLDLSWNQLSGDIPSSLGSARELVYLWLAHNKFRGNIPQSFGNLLGCMNFFNVSSNKLEGEIPEGGPFSNLTGESFMNNYALCGSDRLHFPSCKTKDVFKSRSAKYISLTKCILPPILLFILLLAATAIWWKKRNVRRVEVLLQNEVRMCQTWSKVSYQEILDATDSFSENNLLGFGSFGSVYRGVFSDGSSVAIKVFHLQAEGSKKSFDAECQQHPAISDFGIAKLFGEDENTVQTKTTIRYMAPEYGLQGIVSTSGDVYSYGVLLLETFTRKKPTDHLFGEELNLKHWFSKAIQAKSIVSVVDSNLITQEDRQFYARKQCLFSNLRLGLDCLADSPRERTNMREIVTRLKTSSTTIDNISCFICYTFLIFGLILLSSLIMFWILTNWSHIFLLENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYX4</accession>
    <name>A0A068TYX4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00036528001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYX4"/>
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        <property type="gene ID" value="GSCOC_T00036528001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYX4"/>
    <dbReference type="OMA" id="NGNEEWM"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="82" mass="8776" checksum="C7922204836198A6" modified="2014-10-01" version="1">MSIEALAMAGADYIKCSISLEVWEGLGTVETPAYLLAEEDLQNPVIKSKVDDLVSDNENFAAQILAVAKAVVSTETKASEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZG0</accession>
    <name>A0A068TZG0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032775001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZG0"/>
    <dbReference type="STRING" id="49390.A0A068TZG0"/>
    <dbReference type="Gramene" id="CDP00718">
        <property type="protein sequence ID" value="CDP00718"/>
        <property type="gene ID" value="GSCOC_T00032775001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZG0"/>
    <dbReference type="OMA" id="KTGHRRH"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37715">
        <property type="entry name" value="OS01G0120700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37715:SF1">
        <property type="entry name" value="OS01G0120700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
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            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="268"/>
        </location>
    </feature>
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            <end position="291"/>
        </location>
    </feature>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="334" mass="38855" checksum="8B194993E2A23D4E" modified="2014-10-01" version="1">MDAKKFIQLVEEKKKRMMERKEAPLKWEQKLEAAAKARADAEKERKMKATKHKKRSVPGSESDCSSDSSSDERKSAKRPHRKHRKHNHSDSGDNEKRRDKKSRHKSKRRSSDSGDDSSGCDTDSQEERRRKKQRQKRRRHHDSRSDSSGADYSDDESDIDMRRRNRIKSHKRHRRSHSSDSESASDDDYPGRKRNRARHHKRSRRSGSSDSDSSSDDDTPKRSRHAKHHKHHRGTRTHDSVSSDSEDHRRDGSRSLGKSSDDDFGKVEKQKKHHHGHGRHHHHHHHNNHNRIHSDETPLNDQQAGKATESNGKNTLREANMDNSHDKAVDQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0U3</accession>
    <name>A0A068U0U3_COFCA</name>
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        <recommendedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00034767001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
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    </reference>
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        <property type="gene ID" value="GSCOC_T00034767001"/>
    </dbReference>
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    <dbReference type="OMA" id="WIPAPRE"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Transducin/WD40 repeat-like superfamily protein"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
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            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
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            <end position="351"/>
        </location>
    </feature>
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        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP01198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50414" checksum="451F5824BBD47D18" modified="2014-10-01" version="1">MWKEIGDREFGKLRPNLFSSRIKSGRNSSIQLSNHKEIVSAHRGSVNSLQVDLTEGRYLLAGAADSSVAVYDVQCASREGNGLIARHKSLFVVDKQHEHGHKYAISSVTWYPIDTGLFITGSYDHHINVWDTNTTQVVMDFKMPGKVYRTAMSSLATSHMLIAAGTEDVQVRLCDIASGAFAHTLSGHRDGVMSVEWSSSSEWILITGGCDGAIRFWDIRRAGCFHVLDQSRSQLGRRPPLLVRSTANKVITSKSSSINPSSSVKSRPPQRKTNNGNSSKHGGLNKHSSQLKGSVKQRLHPGMLSTQDRATAHYGAVFGLRATGDGMYLLSAGSDSRLRLWDIESGCNTLVNFEITRLQTSKPLQLATTQDSALVFVPCMTTAKAFDMWSGKTLMNFRGHYENVNCCWYSAQDQELYTGGNDRQILVWSPSNFTTGEVDEWRKGQGAALDQDNWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1I4</accession>
    <name>A0A068U1I4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00039766001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30403"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="EC" id="7.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1I4"/>
    <dbReference type="FunCoup" id="A0A068U1I4">
        <property type="interactions" value="1405"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1I4"/>
    <dbReference type="Gramene" id="CDP02400">
        <property type="protein sequence ID" value="CDP02400"/>
        <property type="gene ID" value="GSCOC_T00039766001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1I4"/>
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    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
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    <evidence type="ECO:0000313" key="16">
        <source>
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        </source>
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    <sequence length="232" mass="25453" checksum="3993C26489CF491A" modified="2014-10-01" version="1">MAVPVVRFPIYGVVRILGIAVTVTVLTWTVHYRGGLALVSTNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVPGTKSFKKLVHLLLQFLALSFSVIGLWAAWKFHNDKGIDNFYSLHSWLGLACLFLFAIQWAAGFVTFWYPGGSRNSRASLLPWHVFFGVYIYALAIATCTTGILEKATFLQTNQIMSRYSKEALLVNSLGILIVALGGFVILAVISPANGKSDVTKSTVE</sequence>
</entry>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
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                <person name="Rouard M."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
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                <person name="Jayarama X."/>
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                <person name="Giuliano G."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="210" mass="23484" checksum="BBFE1ABA1C4277F3" modified="2014-10-01" version="1">MASSTKLRRSSCSFPIVLVSFLNFILFILSSASLAPIILLKTPPTCLGWAFLTVSCISLLSSFIGFYSQLTHFCFMTHVSLLLTSLIGQILAIVALFRKEKSSLSMLKSPRDPREAKLLVRMECGVLMAMFVMQVGVLILTCAVHSCLMREYEGLEADKEAVERKRSMRIAKVQEESMANAAKLAEIKSKKLDERVKSKYGQWVKTDFEG</sequence>
</entry>
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    <name>A0A068U3I5_COFCA</name>
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        <recommendedName>
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    <organism evidence="8 9">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>asterids</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
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                <person name="Alberti A."/>
                <person name="Anthony F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">cv. DH200-94</strain>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="entry name" value="Transcription initiation factor TFIID subunit 13"/>
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    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="14485" checksum="F95384B4A8BAB5D7" modified="2014-10-01" version="1">MNNPSAGPSSKTKVGSSQSSETSFKRKRGVFQKDLQHMMYGFGDDPNPFPETVALVEDIVVEYVTDMVHKAQDIASKRGKLLTEDFLFLIRKDLPKLNRCTELLSMNEELKQARKAFEVDEEKLASTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U465</accession>
    <name>A0A068U465_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FGGY carbohydrate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041392001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U465"/>
    <dbReference type="FunCoup" id="A0A068U465">
        <property type="interactions" value="1653"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U465"/>
    <dbReference type="Gramene" id="CDP02954">
        <property type="protein sequence ID" value="CDP02954"/>
        <property type="gene ID" value="GSCOC_T00041392001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U465"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U465"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000101">
        <property type="entry name" value="FGGY carbohydrate kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="354"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="622" mass="67748" checksum="BD963FE3F9A7772D" modified="2014-10-01" version="1">MSGPRHSYSDTTPLLKQHHHDDDHHHHHHHHRFSSHPAAIEMTTPPPPRRSVYLGVDVGTGSARAGLFDGDGKLLGSASSPIQIWKEGDCIEQSSTDIWLAVCTAVKAACSLANVAGEEVTSLGFAATCSLVAVDSDGEPVSVSWSGDTRRNIIVWMDHRAVKQAERINSSNSPVLQYCGGAVFPEMEPPKLLWVKDNLKESWSMAFRWMDLSDWLSYKATGDDTRSLCSTVCKWTYLGHAHMHQASEEDSRDMEACGWDDQFWEEIGLGDLVDGHHAKIGRSVAFPGHALGCGLTIDSAKARSHSELGLLAGTPVGTSMIDAHAGGVGVMESKAGSDPESKETDVEAICRRMVLVCGTSTCHMAVSHTKLFIPGVWGPFWSGMVPEYWLTEGGQSATGALLDYVIENHVASPHLVKSAASRRISIFELLNEILETMRHELGSPFLAALTNDTHVLPDFHGNRSPIADPKSKGMLCGLTLDASEKQLALLYLATVQAIAYGTRHIVEHCNAHGHKVDTLLACGGLAKNPLYIQEHADIIGYPIILPRENESVLLGAAILGAVASKKYITIRHAMKALNAAGQVVYPSQDPKVKNYHNAKYHIFRGLYEQQLEHRSIMAKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4F9</accession>
    <name>A0A068U4F9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00041969001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4F9"/>
    <dbReference type="FunCoup" id="A0A068U4F9">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4F9"/>
    <dbReference type="Gramene" id="CDP03396">
        <property type="protein sequence ID" value="CDP03396"/>
        <property type="gene ID" value="GSCOC_T00041969001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4F9"/>
    <dbReference type="OMA" id="KEVNPWM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4F9"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="54"/>
        </location>
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        <location>
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        </location>
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</entry>
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                <person name="Rouard M."/>
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            <end position="213"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP04335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="86961" checksum="31275BF38A57C24D" modified="2014-10-01" version="1">MRGVRVDVDGLPTKGLVEVNQDHVRDDQRAVKNEITGDGHGISEEGESRTNEEVNNGRIDLVQAQTVLLAQHHQQQQPQGPVVRWERFLPFRSLKVLLVENDDSTRHVVSALLRNCSYEVTAVSNGVEAWKLLEDLTNHIDLVLTEVAMPCLSGIGLLSKIMNHKTCKNIPVIMMSSNDSMGIVFKCLSKGAVDFLVKPIRKNELKNLWQHVWRKCHSSSGSGSESGIRTQKSTKSKSVEGSENNTDSNDEDDNGSIGLNYRDGSDNGSGTQQSSWSKRAVEVDSPQRMSPWDDLADPPDSTCAQVIHSRPEAHSSNWVPVNATRKAHECDDDPDNVAMGKDLRIGVPRDPDLQLKDQSDEVQGNMASTEKHKFSTPDIKKDGEKMEKGMVEYRNEMAKDEIQDKDNDLMGAITNITMTHGGNAHNEVQNDPSKIAVQKDMDLYNAKELPSLELSLKRLRDVGNGGNSTQERNILRHSDHSAFSRYNTTSTTNQAPTGIVGSCSPVNNSSEAAKTESMQNLQSNSSGTPNQGSNGSSNNNDMGSTTNNAFTKVETFGEKTTPRAAVSVRPCSAFQPVQNGYDTSPQPMTAGKPDSAKTMVAQARAMHQQPQVEHHHHHHYHHHHHHVHSLQQQQQLLNGDDLSLRNMMSGAPQCGPSNMLGVAIEGNAANYGSASGSNNGSNGQNGSSGQNGSSTAVIVEGTNVASDNGATGKCGAGGGIASGSRSCVDQDRLSQREAALYKFRQKRKERCFEKKVRYQSRKKLAEQRPRVRGQFVRQTVDDNKSKDRDKDPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U751</accession>
    <name>A0A068U751_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00017672001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Lambda family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U751"/>
    <dbReference type="FunCoup" id="A0A068U751">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U751"/>
    <dbReference type="Gramene" id="CDP04321">
        <property type="protein sequence ID" value="CDP04321"/>
        <property type="gene ID" value="GSCOC_T00017672001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U751"/>
    <dbReference type="OMA" id="SCLRFMG"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U751"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03203">
        <property type="entry name" value="GST_C_Lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000091">
        <property type="entry name" value="Glutathione S-transferase L2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000041">
        <property type="entry name" value="Lambda class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044629">
        <property type="entry name" value="GSTL1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44328">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44328:SF11">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE L2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0216">Detoxification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="238" mass="26781" checksum="28BB34B623BCB6C1" modified="2014-10-01" version="1">MASGVKEVLPPTLDPASEFPADIFDGTTKLFIAYVCPFAQRVWITRNCKGLQDKIKVIAVDLDNRPAWYKEKVYPANKVPSLVHNNEVKGESLDLIRYLDEKFEGPSLLPEDPAKTEFAEELLSYSDSFNGAVFSSIRADGIGEVGSAFDYLENALGKFDDGPFFLGTFSLVDIAYAPFVERFQPFLLDVKKYDITEGRPKLAAWIEEVNKIEAYKATKYDQNELLASLKRRFGLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7B9</accession>
    <name>A0A068U7B9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00015904001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7B9"/>
    <dbReference type="Gramene" id="CDP03508">
        <property type="protein sequence ID" value="CDP03508"/>
        <property type="gene ID" value="GSCOC_T00015904001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7B9"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7B9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP03508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="91" mass="10485" checksum="5FD1094DF52EB1E4" modified="2014-10-01" version="1">MEEEVRMLLQDAFGESSDGEGGDEAQERKSQDLNKLSIFGEIQNWERIDQIKGLWLCRDFLSPDQQSSLLSAIQKGTSINFRIKLNLFEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8C4</accession>
    <name>A0A068U8C4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00018776001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8C4"/>
    <dbReference type="FunCoup" id="A0A068U8C4">
        <property type="interactions" value="1738"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8C4"/>
    <dbReference type="Gramene" id="CDP04711">
        <property type="protein sequence ID" value="CDP04711"/>
        <property type="gene ID" value="GSCOC_T00018776001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8C4"/>
    <dbReference type="OMA" id="YYALRFS"/>
    <dbReference type="OrthoDB" id="2012966at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8C4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF15">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP04711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="510" mass="58098" checksum="83F26935A46D70A7" modified="2014-10-01" version="1">MVNYRGFSSHSKNSSIYFRRYSSPSSITYYIVILFALSIFIFTFYSKDVLEDEDRKPPSITSGEKNPKIEQLRDDVLWEAPFSHGLRPCVKPSSRYKATQGWDHYMTVRSNGGLNQMRAGIADMVAVAHIMNATLVIPQLDKRSFWQDTSIFSDIFDEVHFIMTLQTDVRIVKELPKELESAPRARKHFSSWSGVSYYEEMAHLWKDYQVIHVAKSDSRLANNDLPFDIQRLRCRALYHALRFSPAIENLGKKLVERLRSRAERYIALHLRYEKDMLSFTGCTHGLTEAEAEELRVMRHNTNHWKIKNINATEQRIGGLCPLTPKEVGIFLQALGYPPSTLIYIAAGEIYGGSVHLSELTSRFPNIVYKEALASKGELQAFSHHASQSAALDYIISIESDVFIPSHSGNMARAVEGHRRFLGHRKTITPDRKGLVAIYDMLESGVLKEGSSSLSHLVMKLHRSRQGAPRKREGAPSGIKGRGRFRLEEPFYQNPFPECMCGSNIQDDEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9A9</accession>
    <name>A0A068U9A9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSCOC_T00018859001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="18"/>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9A9"/>
    <dbReference type="STRING" id="49390.A0A068U9A9"/>
    <dbReference type="Gramene" id="CDP04764">
        <property type="protein sequence ID" value="CDP04764"/>
        <property type="gene ID" value="GSCOC_T00018859001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9A9"/>
    <dbReference type="OMA" id="IMVMRAS"/>
    <dbReference type="OrthoDB" id="758220at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9A9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000237">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000013">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase LECRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF7">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654683" description="Receptor-like serine/threonine-protein kinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="22">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="22">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="23">
        <location>
            <begin position="329"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="487"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDP04764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="915" mass="102912" checksum="EE4E16BAE17F2959" modified="2014-10-01" version="1">MAAFLFFFLLSTFHSRIAAQQRPLNISLGSSLTPTGNSSSWLSPSGIFALGFYQQRNGYAVGIFLAGIPQKTAVWTANRDSPIFSSNVSLILSTDGRLILQQPEGQDITVVDPSESISSASMLDSGNFVLYNSDKEIIWQSFEHPTNSLLPRQQLIPGQELISSASETDDSRGIFRLVMQTDGNLVQYPVGAANGPENAYWVSKTFGDGPNVTLNLEDDGHLYLTNSSVNLVKNLSDGGHPKNKMIYLMKIDVDGIFRLYSYSVDQGRNWSIIWESSTDRCDPKGLCGFNGFCTKIDNLVDCKCLPGFQFVNQGNWRLGCERSFVTDSCNSTDSNVNYTIEFLENTVWEDNTFSMVNTGTREDCAKICLEDCNCEAAFFKDGQCKKQRLPLTYGKRETDSNIALVKVHKHATIDEGKNRKEEDRVYILKIGISLAVFGALISLFAGVYVHRNRARACKQVLGNGNVEFDKNVAPRAFTFAELEQATNEFREELGRGAFGTVYKGILPNSNKVVAVKKLEKGLAEGGEREFQNEISVIGKTHHRNLVQLLGYCLDGAKRLLVYEYMRNGSLEKILHKPENHPSWDERMKIACDIARGILYLHEECETQIIHCDIKPQNVLMDESRCAKISDFGLAKLLKNDQTRTYTGVRGTRGYVAPEWFRNLPVTVKADVYSFGIMLLEIICCRKSVDCTSPENEAILEEWANQCFEAGELYKLVGDEEVDDVRELERMIKIALWCIQEEPALRPSMKKVLLMLEGTGDIPIPPSLPSFSSLIRHANKHFKSKTRFDLLLEQDQIEPSHQARVEIFTRHEEFGIMLLEIICCRKSVECTSPENEAILEEWAYQCFEAGELYKLVGDQEVDDVREPERMIKIALWCIQEEPALRPSMKKVLLMLEGIVDIPIPPSLPSFSSAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9L9</accession>
    <name>A0A068U9L9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00017642001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9L9"/>
    <dbReference type="FunCoup" id="A0A068U9L9">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9L9"/>
    <dbReference type="Gramene" id="CDP04298">
        <property type="protein sequence ID" value="CDP04298"/>
        <property type="gene ID" value="GSCOC_T00017642001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9L9"/>
    <dbReference type="OMA" id="GANEQDC"/>
    <dbReference type="OrthoDB" id="1934880at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9L9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000001">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021820">
        <property type="entry name" value="S-locus_recpt_kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1082">
        <property type="entry name" value="OS06G0693000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11883">
        <property type="entry name" value="DUF3403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BULB_LECTIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657457" description="Receptor-like serine/threonine-protein kinase" evidence="18">
        <location>
            <begin position="29"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="20">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="21">
        <location>
            <begin position="340"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="516"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP04298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="829" mass="92705" checksum="12E5376756EB9D34" modified="2014-10-01" version="1">MAIKMRGLKNLLPLLFLFACFWLEDCIAMDTITIDHPIKDPETIVSSGQSFTLGFFTPVNSNNRYVGITINIPAQSVVWVANRDNPIKDSAGSLAISGDGDLVVLNGQKEVLWSSNVSNSVANSSAQLLDTGNLVLRDNSNGRVLWESFQTPTDTIVRTMNIGVISKNNMIRLTSWRSPSDPSAGNFSFGVDPLRLPEFFIWNHSKPYWRSGPWNGNVFIGIPEMGTSYLRRFDLITDQNGSQYFTHSFTSNLALYDYVLNSSGVLMEKVSYYGDGHSDVSWTSLESQCDVYGKCGPFGSCNPQHSPICTCLQGFEPKNKEEWDEGNYTSGCSRKALLQCDRNISAGQDGKPDVFLKLNNIKVPDFSHLMLFLRATEEECGIQCLNNCSCIAYAYTAGIGCMHWNSSLIDIQQFSFNGADLHVKVAYSKPGFSNRIKAVIASTVILGSLFLAISAYFLRKRLTRHRGNKQNVNLTLSEAWEVSRMETGVSDNSEQSKLEELPLYSYETLANATENFHAKNKLGTGGFGPVFKGELFNGQQVAVKRLSNSSNQGIKEFMNEVVLISKLQHRNLVRLLGCCVQREEKMLVYEYMPNKSLDSYVIDSKKRNLLDWNRRKFIIEGIGRGLLYLHRDSRLKIIHRDLKLSNILLDEELNPKISDFGLARIFGGKEDQANTNRVVGTYGYMAPEYAMGGQFSEKSDVYSFGVLLLEIVSGKKNTSFHYEENKLSLIGYAWKLWTLKQAIILIDPLLSDPRIEMEVLRYVHAGILCVQESASDRPNMSNVLSMLNSEIAELPPPKLPAYTATLGLSESESSQHSVNDVSLTTLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB91</accession>
    <name>A0A068UB91_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00020957001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739102">
        <property type="protein sequence ID" value="CDP05716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB91"/>
    <dbReference type="FunCoup" id="A0A068UB91">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB91"/>
    <dbReference type="Gramene" id="CDP05716">
        <property type="protein sequence ID" value="CDP05716"/>
        <property type="gene ID" value="GSCOC_T00020957001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB91"/>
    <dbReference type="OMA" id="RMMGVFD"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB91"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd10463">
        <property type="entry name" value="PUB_WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47796:SF1">
        <property type="entry name" value="OS08G0500800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47796">
        <property type="entry name" value="ZINC METALLOPROTEINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="132"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="621" mass="68717" checksum="76F686C6277E70C2" modified="2014-10-01" version="1">MMQPPEKQLSVTWRGKKFILEMKHGANLKELGDKLQQLTNVKVDTLRLIVPTNKGSKMLYPFSDEHSYLSLEAASAIEGKPIRMMGVPENEVEEVLENAKKDPRIAGFDEEEKRMRQRTLDGHNSFVRLPQGTYIFSEFHTLSIPGIELSPPASEALKLMHRLAADPGIVAIMNKHRWQVGIMSEMAPVGYVGVSPKCILGFNKNHGEEISLRLRTDDLNGFRKYESIKKTLLHELAHMVYSEHDANFYALDKQLNKEAVALDWTKSTGYTLNGFRHGLHAEDEFDGHVSLSRKLGGNESHFSNARVSAVAAAYHRVANACTNVSAAVNKRDEPDPDDSGFTNCCEPDSLHAEGETKDGHSNIASSMKLVDEHEIHDNEAEPDPDDSESMGAMESESYLVSGGSQITIEPDPDDLEVLTSAADKESVLCNLKVPLTDHSVVGPNFFGAKEGTGNLNQLDVIHVEPDPDDSQAGDSDDKMIVIAERMSMGQGDEPDPDDLELKRIKDPVTAVYGRIQKAVGKLITEVNHSDAGGVLQTLCKIIRNIVEHPDEMKFRRIRKANAIIQRNILQYGAATEILQLVGFSDDVIFDVTGKAETYLALKRNDPGLLWLVKSSLESSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBP3</accession>
    <name>A0A068UBP3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00020854001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBP3"/>
    <dbReference type="STRING" id="49390.A0A068UBP3"/>
    <dbReference type="Gramene" id="CDP05667">
        <property type="protein sequence ID" value="CDP05667"/>
        <property type="gene ID" value="GSCOC_T00020854001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBP3"/>
    <dbReference type="OMA" id="KCHAREL"/>
    <dbReference type="OrthoDB" id="1274461at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBP3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd22160">
        <property type="entry name" value="F-box_AtFBL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053781">
        <property type="entry name" value="F-box_AtFBL13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006566">
        <property type="entry name" value="FBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF312">
        <property type="entry name" value="CYCLIN-LIKE F-BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08387">
        <property type="entry name" value="FBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP05667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="426" mass="48523" checksum="04381727D4B8435D" modified="2014-10-01" version="1">MSTAANFRNVKMSACDRISDLPSSIIESILMWLPTRDAARTSILSRKWRYNWSRIPQLVLDDKIFNKILTNHALRRQKFAEILFQILSLHQGPISKFRCSLTGLKDCRDIDSLIVLLSRSGVQEFTLNLWLNEYHRMPLAFFSCLELRHLNLRGCLIKPPTNFQGFGHLISLKLCQVNIAEDVLGSLMSSSLLLEQLTVVEIPAILNSLELIAPKLKSVFFKSSVKSILFKNTPVLARVSLVPRNQDMDGKFHVIVYIFTMGVYCFALKSLDAGGIPAKITTTLIHLKVVKLEYLCFEEVNEIAILLCLLRSSPNLEELEILVYKVDEYAEGQASNFLDVQEYSQLTLNQLRQVKLQNISGTRSEMEIIKLLLKKSSILEKMLIKQAPMKENIKNKVTEIGILKQVTRFHRSSPRAAVIYEDPIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBZ1</accession>
    <name>A0A068UBZ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00021441001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBZ1"/>
    <dbReference type="Gramene" id="CDP06080">
        <property type="protein sequence ID" value="CDP06080"/>
        <property type="gene ID" value="GSCOC_T00021441001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBZ1"/>
    <dbReference type="OMA" id="QGFVPKM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBZ1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45983" checksum="91D8D939F924C9BF" modified="2014-10-01" version="1">MISRSLLVKNAKFRLAIFKSSLFYQSLLQRSNFLTSSHPFSPSQESHIPNLANHKDWLSPNETIKIFQSLKDPNFTLPLFNQISQRKDYNPNEALYSTVINKLALAKDFDAIEALMEKIKLERKCRLSEEFFVNVMKIYGNLGGRINSAIKTLFDMPSYKSWPTVKSFNFVLNLLVSAKQFEVIHEVYMGASRLGIEIDACSLNIMIKGLCQCGKIDAAFAVLDEFPKQNFRPSVRTFSTIMHGLCDRGRPDDAFGLLDRMERDGIEPDAITFNILISGLKKSGRVEEGITLYDRMMIKGCDPNPGTYQEVLYCLLDAKRFVEAKDFMCRMIQKGVNPSFESYKLVIQGFCNENLVGDVEWALKQMTRQGFVPKMGMWKRIVQCLVSGRIEPTIFPYEEIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC05</accession>
    <name>A0A068UC05_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00020122001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC05"/>
    <dbReference type="FunCoup" id="A0A068UC05">
        <property type="interactions" value="1851"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC05"/>
    <dbReference type="Gramene" id="CDP05168">
        <property type="protein sequence ID" value="CDP05168"/>
        <property type="gene ID" value="GSCOC_T00020122001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC05"/>
    <dbReference type="OMA" id="NGPSYHD"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC05"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06632">
        <property type="entry name" value="STKc_MEKK1_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000186">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF45">
        <property type="entry name" value="OS04G0559800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="412"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP05168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="893" mass="96087" checksum="03E0A0F0809F86C8" modified="2014-10-01" version="1">MPSWWGKSSSKEAKKKPTRESIIDTLHRKLKFPSESKSTGRSGGSRRRSSDTFSEKGSQSRAESRSPSPSKHVSRCQSFAERPQAQPLPLPGLRPASVLRTDSGISSSGKPKVEKSSKPSSFLPLPRPACIRHITDSAELDEELVIASISSECSIESDDQTDSRQRSPLESDYELGSRTATGSPSSMIIKDQSPVALKSPRGSPGAVDLLTHKSVLSSPPKRRPLSSHVPNLHVPCHGAFCSAPDSSMSSPSRSPMRAFGNDQVTGSGFWLGKPYPDLPLLGSGHCSSPGSGQNSGHNSMGGDMSGQLFWQPSRGSPEYSPIPSPRKTSPGPSSRIHSGAVTPIHPRAGGGAHESQTNRSDDGKQQSHRLPLPPVTISNSSPFSHSNSAATSPSVPRSPGRAENLASPGSRWKKGKLLGRGTFGHVYVGFNSESGEMCAMKEVTLFSDDAKSKESAKQLGQEIIMLSRLRHSNIVQYYGSETVGDKLYIYLEYVSGGSIFKLLQEYGQFGESAIRSYTQQILSGLAYLHTKNTVHRDIKGANILVDPNGRVKLADFGMAKHITGQSCPLSFKGSPYWMAPEVIKNSNGCNLAVDIWSLGCTVLEMATAKPPWSQYEGVAAMFKIGNSKELPAIPDDLSEEGKDFVRQCLQRNPLHRPTAAQLLDHPFVKNAAPLDKPLASTDPTSVVVNGVKSPGIEHGRNLPTSESERLAIHSSRVSKSNFHSSDIHIQRNISCPVSPIGSPLLHPRSPPHLNGRMSPSPISSPRTTSGSSTPLSGGAGAIPFQHLNQSTYLQEGFGSVPKTPQSPYINGPLYWDSDMFRGMQAGSAFRDLTSSENDALSKQFGRPVFGELHDGQSVLADRVSQQLLGDPVKLNPSLDLNSRSRLTGRTNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC72</accession>
    <name>A0A068UC72_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021472001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC72"/>
    <dbReference type="Gramene" id="CDP06096">
        <property type="protein sequence ID" value="CDP06096"/>
        <property type="gene ID" value="GSCOC_T00021472001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC72"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="101" mass="12000" checksum="4121DFBBFF6FAB67" modified="2014-10-01" version="1">MTDGPYKFIEENQQLLVICRTQCCVFLLIELNDPTTSTMSKSKYKKVKPIPLSIIWIERNFLSHGRFCAFFQFRRFILFSFGNFLFIFVLSKCRAKLQPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC97</accession>
    <name>A0A068UC97_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1771 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021219001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC97"/>
    <dbReference type="FunCoup" id="A0A068UC97">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UC97"/>
    <dbReference type="Gramene" id="CDP05902">
        <property type="protein sequence ID" value="CDP05902"/>
        <property type="gene ID" value="GSCOC_T00021219001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC97"/>
    <dbReference type="OMA" id="ITMKEYY"/>
    <dbReference type="OrthoDB" id="1928104at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UC97"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056254">
        <property type="entry name" value="At5g58720/SDE5-like_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47872">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR SDE5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47872:SF1">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR SDE5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24767">
        <property type="entry name" value="UBA_At5g58720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1771" evidence="2">
        <location>
            <begin position="311"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="468" mass="53182" checksum="3F387BA4415E629B" modified="2014-10-01" version="1">MEPEELPSTLSYYDNDKRNLEQLLETFGSVVSLDDIASAYCQSEEELQSANASSVCPSDNSVEMAQDSKSKPRKSPACMGIVSSVIGKQYVMPKTSTNGSCKPKPLILNSDDIPVSEVWDEKDFLNSTERSGTMSHDIEEFLFKMLGEGFSLNKSVIQDIVGQCGYDVTKSMDKLLDLSASTLGKSDDVLKASSEKPKQGYRNMVSLLPEDQIPCTSFESLKYTPDTGNVEHLADRRNRHDLEKEVLGTLFTVRPRPEPEPKKYHPMKEVRRSSLHHFIVEEPLKETVIEDEPVIRTKQVSENSNEENEDDYDVLRKAVMEYWTTMKEYYKAAADAFAINDHEKAHKLMEEGHFFMKKAREADEKSAEKLIESNDEEEMFVDLNEFEPKDALRFLKIQLTSLSGIASYKYLKVLVGSNEQNAKSGPRKRLITKLLERENIKWSEEGDGWVIVIQLDVIDPKKLSFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCE1</accession>
    <name>A0A068UCE1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00021176001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCE1"/>
    <dbReference type="Gramene" id="CDP05869">
        <property type="protein sequence ID" value="CDP05869"/>
        <property type="gene ID" value="GSCOC_T00021176001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCE1"/>
    <dbReference type="OMA" id="HTVGREY"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45277">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45277:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="117"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="299" mass="33013" checksum="01BA4CBD8D86962C" modified="2014-10-01" version="1">MGKSGRDWTQIYAIYGMDDWHTPFFLLIHAVFFSALSVFFLLYFEPICFLTQHFLPIIGPGLARFIAGFTGSVTALSAVCLFFAAANFFYSSVSLHWDMAQRMVNSVSDWSSVKQALDLGCGRGILLNAVAMQLKKSGSSGRVVGLDPTGARRNGPSTLSTLRTAGLEGVQEYVTCRAGDPRTLPFSDNYFDVVVSSVFVHTVGKEFGAKSAAAGAERMRVLGEVVRVLKAGGVGVVWDLVHVPEYVQRLHELKMEDIRVSERVTAFMVSSHIVSFKKPNHHFAGSNEVRLDWRFNNLC</sequence>
</entry>
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    <accession>A0A068UD56</accession>
    <name>A0A068UD56_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UD56"/>
    <dbReference type="Gramene" id="CDP06421">
        <property type="protein sequence ID" value="CDP06421"/>
        <property type="gene ID" value="GSCOC_T00023271001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD56"/>
    <dbReference type="OMA" id="FKEGQGW"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD56"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044832">
        <property type="entry name" value="NRP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034:SF7">
        <property type="entry name" value="INFLUENZA VIRUS NS1A-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="60"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="685" mass="76517" checksum="A06209189E3E859E" modified="2014-10-01" version="1">MHIPDPCCCLKGQEPSDMDFPIMHPMGVGRKQENFQLNDNLLPKMKQPATTYFARNLGKSNLGGVIFGCKNNTFKECLSKQIFGLPAQHFLYVKNIDPGLPLFLFNYTDRKLHGIFEAASCGQMNINPYAWTPDGSERTPYPAQVQIRIRLQCQPLLEDQFKPIILDNYYNVSHFWFELDHTQARRLMAKLSAMAIAPSTFVPQNTAKWRNALYGLTSNEKREENGAYEQPVLRNKFVNSPDPGNCQLLESSLGNQESDRDAKDIIYLKLKELAINLESSDAPMRGHVGEIATARDEKLGQESLLAEFSGKKNKNNPVISYDLSDPSLVAQMLEGMKELMAFKEEQIQKANRMEQKLLEAEKEISQLKCRFMMLESRSNTSLVHVDGTGIKSCDDFHLDLDESIFLVGGYDGVLWSSALDLFSPSHDVLKSLKPMSSVRSYSSVAKLNGELYVFGGGTGSAWLDTVESYNFAQDQWSLCSSLNKKKGSLAGATLDNKIFAFGGGNGVDCFSDVEMYDVNVGRWIPTRSMLQKRFALAAAELNGALYAVGGYDGDNYLKSAERFDPREHSWSRIESMNTKRGCHSVVVMNEKIYALGGYDECDMSPSIEIFDPRLGKWMTGEPMNHSRGYSAAAVLKESIYVIGGVKTGGDIVDTIECYKDGQGWQITNLSAPRRRCFCSAIVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UD95</accession>
    <name>A0A068UD95_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023329001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Streptophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UD95"/>
    <dbReference type="STRING" id="49390.A0A068UD95"/>
    <dbReference type="Gramene" id="CDP06466">
        <property type="protein sequence ID" value="CDP06466"/>
        <property type="gene ID" value="GSCOC_T00023329001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UD95"/>
    <dbReference type="OMA" id="KYWHIST"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UD95"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF10">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHATASE SAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="24153" checksum="1F8E4EB9124309FC" modified="2014-10-01" version="1">MEIQESSPCHFKLWSELELHEFSDRFVIKPVESPDQGFSLSRFDGNIEQLDGDLGNTSGKVSTIYGVAGTIRLLAGLHVLVITSRKEVGTFLGYPVYRVMSMKFLSCNEASKFLTNQEKKDESYFMTLLKVVESTMGLYYSYDTDITLNLQRRFKLADGWMSKPIWKQADPRFVWNRNILEELIEKKVDGFIIPLIQGNILDLDSCHHAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDA5</accession>
    <name>A0A068UDA5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00021562001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDA5"/>
    <dbReference type="STRING" id="49390.A0A068UDA5"/>
    <dbReference type="Gramene" id="CDP06164">
        <property type="protein sequence ID" value="CDP06164"/>
        <property type="gene ID" value="GSCOC_T00021562001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDA5"/>
    <dbReference type="PhylomeDB" id="A0A068UDA5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000261">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="344" mass="39159" checksum="9C3147EA42E5C2E7" modified="2014-10-01" version="1">MSFKLCSGFFLQRAVWGYSLSISKLKQLEFLILKNNQLIGPIPSTLSQIPNLKVLDLAQNSLSGEIPRLIYWNEVLQYLGLRGNKLGGTLSPNMCQLMGPWYFDVRNNSLTGSIPENIGNCTAFQVLDLSYNQLTGEIPFNIGFLQVDTFVQCLQVMLEQKEARRVTQSEAYQKRKQEKQLHQGVEEVPVSYELLQNSDYNNQQPIVIEPLLQQNGKKRADRQQCIAIEPVVQQNSEDNFLFKVITQSEGKLKKHVSVLSTFEEGSREIGYGRYLYESSQHVSGLPTLFCHNHITKHSLGHVNHQPTGAIQNLKTTGPLSFKSLVRYFLQRVSSKKHLIRYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UF62</accession>
    <name>A0A068UF62_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023984001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UF62"/>
    <dbReference type="FunCoup" id="A0A068UF62">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UF62"/>
    <dbReference type="Gramene" id="CDP06932">
        <property type="protein sequence ID" value="CDP06932"/>
        <property type="gene ID" value="GSCOC_T00023984001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UF62"/>
    <dbReference type="OMA" id="NMAIFCP"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UF62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000270">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF21">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="340" mass="38850" checksum="1195FA10E9B37DAD" modified="2014-10-01" version="1">MFAQIAVGIVGGFLVWAYLSMKPAPPKICGSPDGPPVTSPRVKLSDGRYLAYKEAGVSKEQAKYKIILIHGFDSSKDMILPISQDLINELQIYLLSFDRAGYGESDPYPKRSVKTEAYDIQELADKLHIGPKFHIFGISMGAYPVWGCLKYIPHRLSGVALVVPFVHYWWPCLPAELSKHSLRKLLVQDQWVFRVAHYTPWLLNWWMTQKWFPSLSIMEGKTDILSSQDLEILKQSSGVLNDGQEKVRQQGLYESLYRDILAGYVQWEFDPTDIADPFPNKEGSVHLWQGCEDRIIPFEINRYISEKLPWIRYHEVPDAGHFLAFNGSLCESIVRELLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGD2</accession>
    <name>A0A068UGD2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024940001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGD2"/>
    <dbReference type="STRING" id="49390.A0A068UGD2"/>
    <dbReference type="Gramene" id="CDP07625">
        <property type="protein sequence ID" value="CDP07625"/>
        <property type="gene ID" value="GSCOC_T00024940001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGD2"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGD2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="50" mass="5458" checksum="AE0A5550F145A68E" modified="2014-10-01" version="1">MEGEKMEKGRVCVTGGTGFLASWLIKRLLEDSYSVNATIRSSSGSCLLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHK3</accession>
    <name>A0A068UHK3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00025506001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739113">
        <property type="protein sequence ID" value="CDP07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHK3"/>
    <dbReference type="Gramene" id="CDP07961">
        <property type="protein sequence ID" value="CDP07961"/>
        <property type="gene ID" value="GSCOC_T00025506001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHK3"/>
    <dbReference type="OMA" id="THNTEVA"/>
    <dbReference type="OrthoDB" id="3027644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHK3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF64">
        <property type="entry name" value="OS12G0206100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="37"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="218" mass="25084" checksum="2D353F88BB24874A" modified="2014-10-01" version="1">MEEGTLSAPTRLQQLRHTYSFVAEEDVVELPNDVQVLVKYLLNVGETEPKISVASIVGMGGIGKTTLARKVYHHETLKHYFEGFAWVCVSQQWQPKDLLQRILVKLISEQSNQIMTSKEDTLARLLQQHLQNRRCLIVLDDIWSTEAWDCLKDAIPVSEHGTKILLTTRNRDVAAHVDPNGYHHQLHFLTEEESWELLRKKSLWESNAAGKMFPLYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UII0</accession>
    <name>A0A068UII0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bax inhibitor 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00027147001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UII0"/>
    <dbReference type="FunCoup" id="A0A068UII0">
        <property type="interactions" value="1813"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UII0"/>
    <dbReference type="Gramene" id="CDP08345">
        <property type="protein sequence ID" value="CDP08345"/>
        <property type="gene ID" value="GSCOC_T00027147001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UII0"/>
    <dbReference type="OMA" id="SRDFIMH"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UII0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10430">
        <property type="entry name" value="BI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP08345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27524" checksum="6CE3ACF9E7CC47FB" modified="2014-10-01" version="1">MEGFTSFFDSQSASRSGWSYESLKNFRQISPVVQNHLKQVYLTLCCALVASAVGAYLHILWNIGGFLTTVGCMGSMMWLLSTPPFEEHKRLSLLMAAAAFEGASIGPLIELAISFDPSILVSAVIGCAIAFGCFSAAAMLARRREYLYLAGLLSSGVSILFWLHFASSIFGGSLALFKFELYFGLLVFVGYIVVDTQDIIEKAHYGDLDYVKHSLTLFVDFVAVFVRVLIIMLKNASEKEEKKRKRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJX7</accession>
    <name>A0A068UJX7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027479001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739118">
        <property type="protein sequence ID" value="CDP08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJX7"/>
    <dbReference type="STRING" id="49390.A0A068UJX7"/>
    <dbReference type="Gramene" id="CDP08534">
        <property type="protein sequence ID" value="CDP08534"/>
        <property type="gene ID" value="GSCOC_T00027479001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJX7"/>
    <dbReference type="OrthoDB" id="1298402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJX7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF263">
        <property type="entry name" value="DUF4005 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="5">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="434" mass="48730" checksum="79F47CFDD7E5187E" modified="2014-10-01" version="1">MGIAGKWIRNFLLGKREEKGKHKKRVNSVATEVITKEKRRWSFKKSTTTDKVTCRNLSFDSISTPHLAKQVLEEHEIEQIRFKAILVTTSKQVNGTMPVVTTPVSQAIGPLKDAAAIKIQAAFRSYLARKALCALRGLVKLQALVRGHLVRKQTTAVLRSMHALMTIQVRARYRRVQMVEAGAELATKRSGHGESARNSTVRPFLDYFLTFPLDDHPSGSAFCRICSSTQILRSNLLDFLFSIELKSGPLHYSQAERKELGVVTTYHSGRFPINMQEDQPDQTCCSPPATVTETSSTNLSKTKQIKLQASTAPLSHENRGYMSNTASSKAKARSHSEPKQRPKKWRPVQKNKQSTSVRGVNVALEVQEQYMPSPSEFDEQENQHPWFIKLYRSAKQVNGSHADHSSVANCNSNFEKTLNPFEACSRYLANTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKC6</accession>
    <name>A0A068UKC6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027790001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKC6"/>
    <dbReference type="FunCoup" id="A0A068UKC6">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKC6"/>
    <dbReference type="Gramene" id="CDP08722">
        <property type="protein sequence ID" value="CDP08722"/>
        <property type="gene ID" value="GSCOC_T00027790001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKC6"/>
    <dbReference type="OMA" id="HPNDSHG"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKC6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF10">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="305" mass="34500" checksum="3A127DCB1D6CD67B" modified="2014-10-01" version="1">MGHAAVWDPRAAIEITKGWNGVDQIVLRNPQGASARVSLHGGQVTSWRNDRGEELLFTSSKAIFKPPKAMRGGIPICFPQFGNCGSLELARNKVWTIDDNLPPFHPNDTYGKSFVDLLLKSSEDDLKCWPHSFEFRLRVSLSSDGNLSLISRIRNVNGKPYSFSFAYHTYFSVSDISEVRIEGLETLDYLDNLCQRERFTEQGDAITFESEVDRIYLSSPNCIAILDHERKRTYVIRKEGLPDMVVWNPWEKKSKAMVDLGDEEYKQMLCVDAAAVEKPITLKPGEEWTGRLELAVVPSSFCSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL65</accession>
    <name>A0A068UL65_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028235001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP09052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068UL65"/>
    <dbReference type="STRING" id="49390.A0A068UL65"/>
    <dbReference type="Gramene" id="CDP09052">
        <property type="protein sequence ID" value="CDP09052"/>
        <property type="gene ID" value="GSCOC_T00028235001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL65"/>
    <dbReference type="OMA" id="CMGGIFN"/>
    <dbReference type="OrthoDB" id="758104at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UL65"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044257">
        <property type="entry name" value="TRM32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47071">
        <property type="entry name" value="PROTEIN TRM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47071:SF2">
        <property type="entry name" value="PROTEIN TRM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4378" evidence="2">
        <location>
            <begin position="626"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="789" mass="89889" checksum="2E484E25CCD90E88" modified="2014-10-01" version="1">MEKNAYMRHVNELDALEHVHPSCMWGFVHAINYHQWHFNLKRMLLQKITPRKRIKGSRNSKAKELLHDPVEQQKLLYEEEKHLSSAKESRSKHKRSLKARIKSLIAEEMSKEGNGKQRVSSNASQPKLQLLFFPSNKENSAKKLPPKMNVQNKRDAHGKSFKELSVKDASKEREHANVLEIFKVNKDLFLEIVQDKDGSLRKFSHTSPGSNAKARLNKSGSFPAADFLQKRSLEPSTLKQKQSETWSAPKGEKLPTGSLLPNLDKFKRSKHARSKSLPLEYINRGSKLVLTPLKESKQLDHFEVKKGRDQANSSDLSVLSEVSSGYVSTKLEKDSDNRDETTTTCRVDEGNSFNSYEAEEYSSDKSKRTHRRSSSLNESMEKYTWLFENNFGKEVKLDQSRSLKLKNEYEMESGGNVSTRFRRIRSVSNVDVYCSFYGDANLDGWPISTVEVENGSHERDSCQDELKPVVVSRNTEEISPGGVEESVHQNELQERDGRANHVENLGESREKIMGSVEDLEEKYDALTVGERTSYSEQENNCFAIDPCELPRPSPVPAFETCFEEDASSSLEFQASEGCAHFDDKESSINCKNSFDMEPSALFSSMPNLDPVKDAELVGSYNEYDADLDYVKDILENSGFGKDAFHMTLHSSNQPIDPLVFDEMEAYWHKECSAEDYCGCYHHQLLFDLVNEKLLHLYGRSFPYYPKALGSSCYVRPFPVGDRIVDEMCNSSVNTLMKLKTEQKQSLECLVALDMGKDDGWMNLQLESECVGLEVEDIIFDELLEELLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UML9</accession>
    <name>A0A068UML9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027980001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UML9"/>
    <dbReference type="FunCoup" id="A0A068UML9">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UML9"/>
    <dbReference type="Gramene" id="CDP08863">
        <property type="protein sequence ID" value="CDP08863"/>
        <property type="gene ID" value="GSCOC_T00027980001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UML9"/>
    <dbReference type="OMA" id="SINCVHP"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UML9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000312">
        <property type="entry name" value="(+)-neomenthol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF98">
        <property type="entry name" value="OS02G0640600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="303" mass="32855" checksum="FB425E2DD304D0F7" modified="2014-10-01" version="1">MTEAKRYAIVTGANKGIGFEVCRHLASKGITVVLTARDEKRGLDALHKLKFSDGLSADRLLFHQLDVADSSSVASLAQFIKTQFGRLDILVNNAGIIGADIDSDAFKAAIAAGAVEEERANKVDWSSSINDTHELAVQCFQTNYYGAKRMIEAFVPLLQLSQSPRVVNVSSGAGKLKNIPSEWARGIFTDVDNLTDERVDEVLNQYLKDLKEGSKEAKGWPSFLSAYTVSKAAMNAYTIVVAKKHPNIKINSVCPGFVKTDINFESGTLTVEEGADSIVRLALLPDDGPSGLFFIRSEISPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMP9</accession>
    <name>A0A068UMP9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00029004001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMP9"/>
    <dbReference type="STRING" id="49390.A0A068UMP9"/>
    <dbReference type="Gramene" id="CDP09577">
        <property type="protein sequence ID" value="CDP09577"/>
        <property type="gene ID" value="GSCOC_T00029004001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMP9"/>
    <dbReference type="PhylomeDB" id="A0A068UMP9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="115" mass="13450" checksum="784148FA46F72CAA" modified="2014-10-01" version="1">MAITDPEIVLQWKLPLNTLYYKRFFAYYAFMFWGSLMVRGEGVSSHMMPLDPMEGLDIFPNPRLLLAKLSVCCYDLAKTCFTSAIERDVYTGDKLEIFVLNVEGTRREYMELRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMS6</accession>
    <name>A0A068UMS6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00028966001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMS6"/>
    <dbReference type="FunCoup" id="A0A068UMS6">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMS6"/>
    <dbReference type="Gramene" id="CDP09549">
        <property type="protein sequence ID" value="CDP09549"/>
        <property type="gene ID" value="GSCOC_T00028966001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMS6"/>
    <dbReference type="OMA" id="FIMLPNV"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMS6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008515">
        <property type="term" value="F:sucrose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071836">
        <property type="term" value="P:nectar secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000003">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF134">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP09549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="280" mass="31201" checksum="9176AF29EC0BD70A" modified="2014-10-01" version="1">MAVLSAQVLALIFGLLVWLSNFEFSTGNIISFLVFLAPLPTFYTIYKKKTSEGFQSIPYVVALFSASLLLYYAFLKTNALLIVTINAIGCIIETIYLSMYVLYAPKTSKMFTLKLLGFFNIGCLGVIVAVSLALAKGAKRVSLVGWFCAVINLAVFAAPLSIMAQVIRTKSVEYMPFTLSFFLTLCATSWFFYGFFVRDYYIAVPNVMGFLFGIVQMILYFIYKNAKKDGEINTKLEGAMEQKEGIQMNIEGVEDKKFSSIEKPKSAAAHKPQDIEMGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UN19</accession>
    <name>A0A068UN19_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00030315001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YTHDF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UN19"/>
    <dbReference type="SMR" id="A0A068UN19"/>
    <dbReference type="FunCoup" id="A0A068UN19">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UN19"/>
    <dbReference type="Gramene" id="CDP09841">
        <property type="protein sequence ID" value="CDP09841"/>
        <property type="gene ID" value="GSCOC_T00030315001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UN19"/>
    <dbReference type="OMA" id="PESSCYR"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UN19"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="3">
        <location>
            <begin position="69"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP09841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="373" mass="42227" checksum="33CEF8DBB206D157" modified="2014-10-01" version="1">MSSDTAKENASVVDSSVTEWKNDRNLDGPESHSYRSNEDGCQIGADEQVHSCEQRQNCSETKKGKPCNTRYFIIKSLNHQNIELSIEKGIWATQVMNEPILEEAFRNSGKVILIFSVNMSGFFQGYAQMMSSIGWRRDNVWSQGTGGNNPWGRTFKVKWLQLHDLPFQKTLHLKNPLNQYKPVKISRDCQELPQDIGEALCELLDGKDDVDVSLKRVEFSKVDLPLRRPCVEPSGSLRFEDFVPSVHMAPTLYPSLVYHHQAEASRFDQGYQRPSAGSHGNVRSDSDTSAQFIGWGKSTERSPLASSLTEDDLLEMTYEEYLEAHSRHNKKLYQSGAVPASNIQKSSVKAARFDDVKLGSSSKKRPRHRSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPA2</accession>
    <name>A0A068UPA2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00030899001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPA2"/>
    <dbReference type="STRING" id="49390.A0A068UPA2"/>
    <dbReference type="Gramene" id="CDP10236">
        <property type="protein sequence ID" value="CDP10236"/>
        <property type="gene ID" value="GSCOC_T00030899001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPA2"/>
    <dbReference type="OMA" id="CITTWAT"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPA2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18076" checksum="6ECA9DAB8BCFC3BE" modified="2014-10-01" version="1">MSVSLTVMTFNLLEDQAEDSPNSWDKRKDICISVITSYSPMILCTQQGVKSQLDYLQQCLTGYNQFGISRKGSEDTSDQYCTIFYDKEKVELLEGGTFWLSESPSVPGSMSWGSIVPCIATWAISFYTLYCLLYIHLFQCCITDHFTLGFLYKLCTHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPF5</accession>
    <name>A0A068UPF5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00030740001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPF5"/>
    <dbReference type="STRING" id="49390.A0A068UPF5"/>
    <dbReference type="Gramene" id="CDP10124">
        <property type="protein sequence ID" value="CDP10124"/>
        <property type="gene ID" value="GSCOC_T00030740001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPF5"/>
    <dbReference type="PhylomeDB" id="A0A068UPF5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP10124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="80" mass="9026" checksum="20E2C3CE37B26224" modified="2014-10-01" version="1">MTSCDLPILQVKIVDDSRPAAHRVVESFLNKFFPSGYPCPIVNEGFLRCTQFQLLKHFTSATLSVSSIQVLFIIYEAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPP0</accession>
    <name>A0A068UPP0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00031273001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPP0"/>
    <dbReference type="STRING" id="49390.A0A068UPP0"/>
    <dbReference type="Gramene" id="CDP10520">
        <property type="protein sequence ID" value="CDP10520"/>
        <property type="gene ID" value="GSCOC_T00031273001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPP0"/>
    <dbReference type="OMA" id="TIAAMIC"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPP0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015145">
        <property type="term" value="F:monosaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17361">
        <property type="entry name" value="MFS_STP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000002">
        <property type="entry name" value="Sugar transport protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044778">
        <property type="entry name" value="MFS_STP/MST-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23500:SF109">
        <property type="entry name" value="SUGAR TRANSPORT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="30"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="538" mass="59059" checksum="00F62D58A152CC1F" modified="2014-10-01" version="1">MAGGSLVPAGVAKERAEEYQGRVTPYVIIACLVAAIGGSIFGYDIGISVIREDTRIRQLFCGFPWLALHIQVLLPNPGGVASMDEFLHRFLYTVYKNEKHAHENNYCKYNNEGLAAFTSSLYLAGLVASLLASPVTRKCGRKRSIIYGGISFLIGAALNAGAINLAMLLLGRIMLGVGIGFGNQAVPLYLSEMAPAHLRGGLNMMFQLATTLGIFSANMINYGTNKIHPWGWRLSLGLAAAPACLMTVGGLLLPETPNSLIERGLEEEGRKVLEKIRGTPNVSAEFEDMVEASKLANSIKHPFRDILKKRNRPQLVMAIFMPMFQILTGINSILFYAPVLFRSMGFKGNAPLYSSALTGAVLASSTLVSMATVDRWGRRFLLIGGGIQMITCQTIVAIILGLKFGNNKELSKGFSVLVVVVMCLFVVAFGWSWGPLGWTVPSEIFPLETRSAGQSITVAVNLLFTFIIAQSFIGLLCAFKFGIFLFFAGWITVMTIFVYIFLPETKGVPIEEMILLWQKHWFWKKIVSENPEVEKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTR8</accession>
    <name>A0A068UTR8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00035262001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTR8"/>
    <dbReference type="FunCoup" id="A0A068UTR8">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTR8"/>
    <dbReference type="Gramene" id="CDP11945">
        <property type="protein sequence ID" value="CDP11945"/>
        <property type="gene ID" value="GSCOC_T00035262001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTR8"/>
    <dbReference type="OMA" id="EFLFFYN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTR8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="156" mass="17776" checksum="BBF56915FFEC1146" modified="2014-10-01" version="1">MSSVKLFDLQRIFDKLDKNGDGLVSLEELMWLLDSIGVRANQDELELLIGKKSLDPIDFVFFHDLVIKGYNLDQSKKLKEKEEDSLLEKDLAKAFEVFDSNGDGFISSEELESALCRLGLWDGGKDCRSMINAYDTNSDGQLDFEEFKNMMLVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTS2</accession>
    <name>A0A068UTS2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00033009001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTS2"/>
    <dbReference type="FunCoup" id="A0A068UTS2">
        <property type="interactions" value="1465"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UTS2"/>
    <dbReference type="Gramene" id="CDP11028">
        <property type="protein sequence ID" value="CDP11028"/>
        <property type="gene ID" value="GSCOC_T00033009001"/>
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    <dbReference type="InParanoid" id="A0A068UTS2"/>
    <dbReference type="OMA" id="GEIITME"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
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    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="461" mass="49365" checksum="2199AD2A4C884B67" modified="2014-10-01" version="1">MSSSIHLFSINPVDFRHSRYSISQNRQVLSPLACLNVDVRAPDSVSSKPPALGQNAQRVKEIMEEENRVLVGTYARAPVVLSSGKGCKLYDIDGREYLDLTAGIAVNALGHGDPDWLQALTDQANTLTHVSNIYYSVPQVELAKRLVASSFADRVFFTNSGTEANEAAIKFARKFQRSLHPSEEQPPVEFIAFSNCFHGRTMGALALTSKEHYRIPFEPVMPGVNFLEYGDTQAATKLISNGKIAAVFVEPIQGEGGIYSATKEFLEALRTACDCAGALLVFDEVQCGLGRAGYLWAHEAYGVYPDMMTLAKPLAGGLPIGAVLTSERVAGCISYGDHGSTFAGSPLVCSAAIAVVDKILKPGFLASVSKKGKYFKDLLVKKLGGNAHVKEVRGLGLIIGIELDVPASPLVDACRQSGLLILTAGKGNVVRLVPPLVISEQELDIAAEILLDCLPALDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UU16</accession>
    <name>A0A068UU16_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00035242001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UU16"/>
    <dbReference type="FunCoup" id="A0A068UU16">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UU16"/>
    <dbReference type="Gramene" id="CDP11931">
        <property type="protein sequence ID" value="CDP11931"/>
        <property type="gene ID" value="GSCOC_T00035242001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UU16"/>
    <dbReference type="OMA" id="GASGKMH"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UU16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="193" mass="22703" checksum="B2DB38BB09D0E458" modified="2014-10-01" version="1">MGRGKIEIKRIENTNNRHVTYSKRKTGIMKKAKEITVLCDAKVSLIIFGTSGKMHEYISPSTNLVEMLDAYQRSTGKKLWDAKHENLSNEIDRVKKENDSMQIELRHLKGEDITSLNYKELMSEIIKMIRKTGEMLEEENKQLQYIWHQQEMANMKGAIGERDDVYQRVRDYPSQMPFAFRVQPMQPNLHERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUB5</accession>
    <name>A0A068UUB5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Acyl-[acyl-carrier-protein] desaturase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00035377001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUB5"/>
    <dbReference type="FunCoup" id="A0A068UUB5">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUB5"/>
    <dbReference type="Gramene" id="CDP12021">
        <property type="protein sequence ID" value="CDP12021"/>
        <property type="gene ID" value="GSCOC_T00035377001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUB5"/>
    <dbReference type="OMA" id="KPVDQCW"/>
    <dbReference type="OrthoDB" id="1924153at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUB5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:stearoyl-[ACP] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000002">
        <property type="entry name" value="Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="ACYL- ACYL-CARRIER-PROTEIN DESATURASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155:SF31">
        <property type="entry name" value="STEAROYL-[ACYL-CARRIER-PROTEIN] 9-DESATURASE 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38238" checksum="B1A1E99A56DE9160" modified="2014-10-01" version="1">MPPEKAEIFKSLEHWATQRLLPLIKPVNQCWQPIEFLPDPAKLSADEFSDRVGALQERTAGLPDEYFVVLVGDMITEDALPTYQSWMNTHEGVRDETGASSSPWAVWTRAWTAEEHRHGDLLKTYLYLSGRVDMLMIDRTVQYLIGAGADVGTDRNPYLGFVYTSFQERATFVTHGNTARLAKEGGDPVLARICGTIAADEKRHEIAYARIVEKLLEIDPNGAMLAISEMMKKKITMPAHLMHDGQDPDLFEHFAAVAQRIGVYTADDYANILEFFIGQWNLEKIQGLAGEARRAQDFVCGLPHRIRKFQERADERAKKLQPRGVNFSWIFNKELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUN3</accession>
    <name>A0A068UUN3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00035370001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739145">
        <property type="protein sequence ID" value="CDP12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUN3"/>
    <dbReference type="FunCoup" id="A0A068UUN3">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUN3"/>
    <dbReference type="Gramene" id="CDP12017">
        <property type="protein sequence ID" value="CDP12017"/>
        <property type="gene ID" value="GSCOC_T00035370001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUN3"/>
    <dbReference type="OMA" id="YFLNMRK"/>
    <dbReference type="OrthoDB" id="1934782at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUN3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000227">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g13880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF441">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="805"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114403" checksum="CD60E68FF9740015" modified="2014-10-01" version="1">MRYTTRFKLPQLRRSSSSLHNHRNFSANPLRNLPQTQPSEPILLQSQEIYKLVLEKCLRECKKVQSRRLFDEMPQKLICSLKAGKTIHSYSLKLGFASKGSLGGAIVDLYSKCGDMEFAEKAFFLLEKKDNLAWNSILSLYSRKGLLKNVVERFSSMRKSGKAPPNQFTYAIVLSVCARLMHVDLGKQVHCSIVKTGYEFDSFCGGALVDMFSKTGNLDDARRIFDDLIEPDTVSWTAMISGYVHAGFPEEALELFEEMRSSGQVPDQVAFGTVINACVRLGRLDDAWRLFSDMPNKNVVTWNVMISGHCKVGYEMDAVKFFLDMIKAGIKPTRSTLGSVLSAIAGVASLELGVQVHAKAMKQGLDANVYVGSSLINMYAKCKRMEAAKQVFNGVSEKNDVIWNALLGGYAQNGHACEVVELFTSMTIAGFQHDEFTYTSILSACSSLENVEMGCQLHSALIKRKYALNLFVGNALVDMYAKCGALKDARKQFELMTTRDNVSWNAIIVGYVQEEEEGEAFDMFHAMKLGGIAPDEVSLASILSACANVQALDKGKQVHCLLIKYGLETSLYTGSSLIDMYSKCGVIGAATEVFSCMPERSVVSTNALIAGYALSNIDCAGSIFKYMLAEGLKPSEVTFASLLDACSDPSKMCLGKQIHCFILKLGISINDEFLAISLLQMYLNSQIETEAIVLFSELPVPKSTVLWTALISGLAQNSYSDEALKFYQEMRLCNAMPDQATFASVLKACSVLASLQNGRKIHSLVVQTGLNEDELTGSALLDMYAKCGDVRSSECIFDEMVTRNDVITWNSMIVGFAKNGYAKNAFKIFEQMKQTNVKPDEVTFLGILTACSHAGMVSEGQRIFHDMVAVYGVQPRLDHYACMIDIFGRWGFLMEAEDFIEKLSFEPDSMIWAPFLSACRLHGDDTRGKHAAEKLIELEPQNSSPYVLLSNIYAALSNWDEVNSLRRDMNEKGVRKSPGCSWITVGEETNYFIAGDKLHRSAGKIYAILTDLMEVMGDESCFSEIQFFMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUU6</accession>
    <name>A0A068UUU6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-aminocyclopropane-1-carboxylate synthase</fullName>
            <ecNumber evidence="8">4.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00035449001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.14" evidence="8"/>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUU6"/>
    <dbReference type="FunCoup" id="A0A068UUU6">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUU6"/>
    <dbReference type="Gramene" id="CDP12072">
        <property type="protein sequence ID" value="CDP12072"/>
        <property type="gene ID" value="GSCOC_T00035449001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUU6"/>
    <dbReference type="OMA" id="WRVITNE"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016847">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009693">
        <property type="term" value="P:ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF6">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0266">Ethylene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="50"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="488" mass="55075" checksum="65A0077F74BFEFAD" modified="2014-10-01" version="1">MEFSLKNEQQQLLSKMATNDGHGENSPYFDGWKAYDSDPYHPTRNPNGVIQMGLAENQLCFDLIEEWVLNNPEASICTAEGANKFMEVAIYQDYHGLPEFRNAVARFMEKVRGERVKFDPNRIVMSGGATGAHETLAFCLADPEDAFLVPTPYYPGFDRDLRWRTGIQLLPIVCHSSNDFKVTKESMEAAYQKAQEANIRVKGFLLNNPSNPLGTVLDRETLIDIVTFINDKNIHLICDEIYSATVFSQPEFISISEIIEHDVQCNRDLIHLVYSLSKDLGFPGFRVGILYSYNDAVVSCARKMSSFGLVSTQTQHLIASMLSDETFTDKIISTSSERLAARHGLFTRGLAQVGIGTLKSSAGLYFWMDLRRLLRESTFEAEMELWRIIIHEVKLNVSPGLSFHCSEPGWFRVCFANMDDESVRVALRRIHKFVLVQGKATEPTTPKSRCGSSKLQLSLSFRRLDERVMGSHMMSPHSPMASPLVRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYD2</accession>
    <name>A0A068UYD2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3 15">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00038198001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Plastid</location>
            <location evidence="15">Chloroplast</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Plastid</location>
        </subcellularLocation>
        <text evidence="15">And non-photosynthetic plastids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3 15"/>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYD2"/>
    <dbReference type="FunCoup" id="A0A068UYD2">
        <property type="interactions" value="2383"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYD2"/>
    <dbReference type="Gramene" id="CDP13307">
        <property type="protein sequence ID" value="CDP13307"/>
        <property type="gene ID" value="GSCOC_T00038198001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYD2"/>
    <dbReference type="OMA" id="LFGVQCD"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYD2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="3oxo_ACP_reduc"/>
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    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
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    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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        <property type="entry name" value="SDR"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="NCBIfam" id="TIGR01830">
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        <property type="entry name" value="PRK07231.1"/>
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    <dbReference type="NCBIfam" id="NF009466">
        <property type="entry name" value="PRK12826.1-2"/>
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    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
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    </dbReference>
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        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
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    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="16">
        <location>
            <begin position="78"/>
            <end position="263"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="84"/>
            <end position="87"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        <location>
            <begin position="227"/>
            <end position="231"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        <location>
            <position position="260"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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            <dbReference type="ARBA" id="ARBA00005194"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
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            <dbReference type="ARBA" id="ARBA00012948"/>
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            <dbReference type="ARBA" id="ARBA00022516"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00822"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP13307.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="320" mass="33233" checksum="3140CC4449050BCC" modified="2014-10-01" version="1">MAASAAGSAVLAFKSAATGGISDRKFAHFKQLSSPLQLRHSLSSQCRSISSFVSSGIKAQVATVEQSGVEAAQKLESPVVIVTGASRGIGKAIALGLGKAGCKVLVNYARSSKEAEDVCKEIETCGGQALTFGGDVSKEADVESMIKTAVDAWGTVDILINNAGITRDGLLMRMKTAQWQEVIDLNLTGVFLCTQAAAKLMMKKKKGRIINIASVVGLVGNIGQANYSAAKAGVIGLTKSVAKEYASRNINVNAVAPGFIASDMTAKLGGDIEKKILETIPLGRYGQPEEVAGLVEFLALSPAASYITGQVFTIDGGMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYR6</accession>
    <name>A0A068UYR6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00038404001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068UYR6">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYR6"/>
    <dbReference type="Gramene" id="CDP13452">
        <property type="protein sequence ID" value="CDP13452"/>
        <property type="gene ID" value="GSCOC_T00038404001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYR6"/>
    <dbReference type="OMA" id="YNTPLET"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYR6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.60:FF:000003">
        <property type="entry name" value="Predicted mechanosensitive ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF20">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="12">
        <location>
            <begin position="577"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="752" mass="85661" checksum="3BAFEB3D0C53C0AA" modified="2014-10-01" version="1">MAENKKTSGEVVVPISGDEKDPKKPPPAASPVRASVDSPSGAQRAPPKIPTTDTLTRRKSIARSVYSKPKSRFGEQSVPVDTNMFDEDISIIQEHAEPSCSSPYRNLSNQPSPNDKMGSSNANTLKETIRNVPITPKTPLMASPGGFGGADEDEEIYKKVSLRNKLRYHRVKVKVLIEWFVFACILGCFVASLTVHKLRQWTIWGLEIWKWCALVMVTVSGMLFTKWLVLFAVLLIELAFLLRKKVLYFVYALRKSVQFCMWLSLVLLTWVLLFRRGVERSHLATKILDYITWTMVTFLIGAFLWLLKTLLLKILASSFHVNAFFDRIQESVFHQYILLTLSGPPVMESAQMLGRANSTVSQFSFRRTKAGKDGKEKKEKAVIDINKLHQMKREKVTAWTMKMLVDVISNTGLTTFSGTLGESVYDGGNEQSDKEITNEEEAIAAAYHIFRNVAQPGCRYIDEMDLRRFMIKEEVDIVLPMIDVAETGQIDRKALTHWVVKVYNGRKALAHALNDTKTAVKQLGKLFTAILIIIIIIIWLLLMEIATTKVLVFLSSQLVLAAFMFGNTCKTIFEAIIFVFVMHPFDVGDRCVVDGVQMVVEEMNILTTVFLRYDNEKIYYPNSVLASKPISNFYRSPDMGDSLEFSIDFKTPLELIGTLKDKIKKYLEKNPSYWHPNHSVVVKEIENVNKIKMAIFFNHTMNFQDYGEKNRRRSELVLEIKRIFEELKIKYDLLPQEIHLVESKSVTTGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYS2</accession>
    <name>A0A068UYS2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037411001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739154">
        <property type="protein sequence ID" value="CDP12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYS2"/>
    <dbReference type="STRING" id="49390.A0A068UYS2"/>
    <dbReference type="Gramene" id="CDP12768">
        <property type="protein sequence ID" value="CDP12768"/>
        <property type="gene ID" value="GSCOC_T00037411001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYS2"/>
    <dbReference type="OMA" id="SSPMQMF"/>
    <dbReference type="OrthoDB" id="591557at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYS2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006527">
        <property type="entry name" value="F-box-assoc_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07734">
        <property type="entry name" value="FBA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="453" mass="51089" checksum="758E00EA6E5CF5FE" modified="2014-10-01" version="1">MLQYFYLNITPNNLRFKQKIIKKKKEKNFSSCAPCCVPTFNRSCTYVFEPIVFTNSRNNATTSLGHHHPSPPSAKSMSLKQLDGSQLPVSTADLAPNIPQELIIDILLRLPARSVGKFRCVSKPWRSLLSDPLFIKAHLTLHHHQPQNYILISSSLPTEKSSLSTLTFTPTGTADHDGVLKRLRLLENRLTDADIVGSCNGLVLVSEFKMKHPFRRLSNLDFMYYLINPTTMELVELPANPLAPVALPIGGAFGYDRSSDDYKVVTLSNCERVTNDVHLDVFSLRSGTWRRIDVLRYRLHFLSGVFLNGAIHWLVKSDVSLILAFDLSCEELKLLPLPSSRPENCLFSRIAVLDGCLTMVATMGYCIDVWMMKEYGVEESWTKFSVTTQNYAALPLPICLLGDDDLVLYVNQKLVVHSLTGETRRDMLFAGDKFRDVKAFCESLVSPICYCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYU6</accession>
    <name>A0A068UYU6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00038363001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYU6"/>
    <dbReference type="FunCoup" id="A0A068UYU6">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYU6"/>
    <dbReference type="Gramene" id="CDP13424">
        <property type="protein sequence ID" value="CDP13424"/>
        <property type="gene ID" value="GSCOC_T00038363001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYU6"/>
    <dbReference type="OMA" id="EYFLHQQ"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048527">
        <property type="term" value="P:lateral root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000005">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000019">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000651">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="11"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="693"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="886"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="409"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP13424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="888" mass="98590" checksum="B153E289F15131EB" modified="2014-10-01" version="1">MAESVELPSRLAILPFRNKVLLPGAIIRIRCTSPSSVKLVEQELWQREEKGLIGILPVRDSAETATVAPSLSQGLGTDSVERNSKSQVGVSDAHKHESKNAQEVIHWHNRGVAARALHLSRGVEKPSGRVTYIVVLEGLCRFNVQELSTRGTYYTARITSLDMTKTEMEQVEQDPDFISLTRQFKATAMELISVLEQKQKTGGRTKVLLETVPVHKLADIFVASFEISFEEQLSMLDSVDVKVRISKATELVDRHLQSIRVAEKITQKVEGQLSKSQKEFLLRQQMRAIKEELGDNDDDEDDLAALERKMQNAGMPAHIWKHAQRELRRLKKMQPQQPGYNSARVYLELLADLPWQKASEEHELDLKAARERLDSDHYGLVKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLASSIAAALGRKFVRISLGGVKDEADIRGHRRTYIGSMPGRLIDGIKRVSVCNPVMLLDEIDKTGSDIRGDPASALLEVLDPEQNKTFNDHYLNVPYDLSKVIFVATANRIQPIPPPLLDRMEVIELPGYTPEEKLRIAMQHLIPRVLDQHGLSFDFLQIPEEMVKLVIQRYTREAGVRNLERNLAALARAAAVKVAEQEEAVPLSKDVQRLASPLLESSLADGAEVEMEVIPMSVNNHDISSAFKASSPLIVDEAMLEKVLGPARYDDRETAERVATPGVSVGLVWTAFGGEVQFVEATAMVGKGDLHLTGQLGDVIKESAQIAMTWVRARATELKLATVEESNLLEGRDIHIHFPAGAVPKDGPSAGVTLVTSLVSLFSQRRVRADTAMTGEMTLRGLVLPVGGIKDKVLAAHRYGIKRVILPERNLKDLVEVPSHVLSSLEILLARRMEDVLEQAFEGGCPWRQHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZC8</accession>
    <name>A0A068UZC8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039029001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZC8"/>
    <dbReference type="FunCoup" id="A0A068UZC8">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZC8"/>
    <dbReference type="Gramene" id="CDP13895">
        <property type="protein sequence ID" value="CDP13895"/>
        <property type="gene ID" value="GSCOC_T00039029001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZC8"/>
    <dbReference type="OMA" id="PPHGRGF"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd01518">
        <property type="entry name" value="RHOD_YceA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001136">
        <property type="entry name" value="PRK00142.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF3">
        <property type="entry name" value="RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="260"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="480" mass="52762" checksum="5028F9EFC5D04813" modified="2014-10-01" version="1">MQLNQPLPLCRPPTPLAAALRMLSPASSLNPSANTRLVNRGTKPTTSTDSSSCTTPIKIHPSSNPKIAFPTSQNFPQALTPFKCSFATTATNPATISNSCEAKMEKLEASNDVCPESPLVVVSFYKFADFPDHADLRKPLKELCERLRVSGGIILAPEGINGSICGTRDSVENVLAFIQNDSRLWGLRRVESPVSPEEEAIHHGHMSSSPLAAGEDAPFRWDHVRVKLKKEIVTLGLPSVSPIERVGEYVSPRDWNALVSEPDVVVIDVRNDYEIRIGKFKGAVDPCTTAFRDFPSWVVDKFGLAEPEDQVETACSPGNTGAAKGKNILPRVAMYCTGGIRCEKASSFLLSKGFKEVYHLEGGILNYLEEVPKTESLWEGECFVFDKRVSVEHGLVQGTFKLCYGCKQPVSDEDMEAPEWEYGVSCPYCYSSKSEEEKERARARQRQFERWGIIGGPDKGRRPVRAGCNGESTGEISNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZH5</accession>
    <name>A0A068UZH5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00039100001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZH5"/>
    <dbReference type="FunCoup" id="A0A068UZH5">
        <property type="interactions" value="1343"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZH5"/>
    <dbReference type="Gramene" id="CDP13950">
        <property type="protein sequence ID" value="CDP13950"/>
        <property type="gene ID" value="GSCOC_T00039100001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZH5"/>
    <dbReference type="OMA" id="LLYGHCC"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZH5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01284">
        <property type="entry name" value="TNASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="4">
        <location>
            <begin position="131"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="324" mass="36902" checksum="0B7ACDD492A7924C" modified="2014-10-01" version="1">MGNALRLFCGYCCKPTSESDSLGGLSALAHDLYNFEITSQVPEGLREHVASSKKAQANWYKKLSAAWRESKPPPKTPEEASRLIIRTLKRHQKADVEGLLAFYRLPLPHTLVELTDGTPPPHPQGLQFELQTLPVDAKAVADGDTITVYVRTTDPRESSSVPRDVQVAAVQRSKARAVKNYAKADALHKQIVDAGYRVLMIQNEEILARKYRIRLRGIDAPESAMPYGKEAKEELTRIVQGKCLRVLVFDEDRYGRSVGDIYCNGIFVQESMLKKGLAWHYTAYDRRPELDKWEKDARAKRLGLWASSNPEKPWEWRKDRREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZK5</accession>
    <name>A0A068UZK5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIN4 pathogenic type III effector avirulence factor Avr cleavage site domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00038741001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZK5"/>
    <dbReference type="FunCoup" id="A0A068UZK5">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZK5"/>
    <dbReference type="Gramene" id="CDP13707">
        <property type="protein sequence ID" value="CDP13707"/>
        <property type="gene ID" value="GSCOC_T00038741001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZK5"/>
    <dbReference type="OMA" id="CCMAQPP"/>
    <dbReference type="OrthoDB" id="1903947at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZK5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040387">
        <property type="entry name" value="RIN4/NOI4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159:SF103">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05627">
        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="8348" checksum="B0298E1DA37BD923" modified="2014-10-01" version="1">MSEKGRPLPKFGEWDVNDPASAEGFTVIFNKARDEKKTGGKPESPSKADAAAKQGVDPVKPQGKNWFCCMQSPHAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZV7</accession>
    <name>A0A068UZV7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039262001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZV7"/>
    <dbReference type="STRING" id="49390.A0A068UZV7"/>
    <dbReference type="Gramene" id="CDP14075">
        <property type="protein sequence ID" value="CDP14075"/>
        <property type="gene ID" value="GSCOC_T00039262001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZV7"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZV7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="133" mass="15525" checksum="E1D27932A40D7351" modified="2014-10-01" version="1">MGENPQKNGRKNKVETSRFSIYKILRDRAQVEQLLRYVIEEPLEDADSKRTFKFPFIACEIFTCEIDVILKTLVEEEELMDLLFSFLEPNRPHSALLAGYFSKAFSFAVLQVVICLMLRKTVPLMNYVQVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V071</accession>
    <name>A0A068V071_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Haem-binding uptake Tiki superfamily ChaN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00039108001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETICULATA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V071"/>
    <dbReference type="FunCoup" id="A0A068V071">
        <property type="interactions" value="1468"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V071"/>
    <dbReference type="Gramene" id="CDP13957">
        <property type="protein sequence ID" value="CDP13957"/>
        <property type="gene ID" value="GSCOC_T00039108001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V071"/>
    <dbReference type="OMA" id="KSYASHW"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V071"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007314">
        <property type="entry name" value="Cofac_haem-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021825">
        <property type="entry name" value="RETICULATA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31620">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31620:SF2">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04187">
        <property type="entry name" value="Cofac_haem_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11891">
        <property type="entry name" value="RETICULATA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Haem-binding uptake Tiki superfamily ChaN" evidence="11">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="594" mass="66068" checksum="F9536D915C2E9372" modified="2014-10-01" version="1">MNARIVYLGEAEQVPVRDDRELELEIVKNLKKRCDEAERRISLALDAFPSNLQALLNEYLDKKIDGETLKSFLRHWPPERWQEYEPLISYCRDNGIQLVACGIPLEILRTVQAEGIHGLSKADRKKFAPPAGSGFISGFSSFSRRSPMDTNYAYQSTPFGPSSYLSLQAKVVEDYTMSQIISEAVTDGGAVTDGGATDMLVVVTGASHVTYGSRGTGLPARISRKMPKKNQVVILLDPERQQIRREGEVPIADFLWYSAARPCSRNCFDRAEIARVMNAAGKKRDALPQDLQKGLDLGLVSPEVLQNFFDLEKYPVISDLSHRFQGFRERLLADPKFLHRLAIEEAISITTTLLAQYERRKENFFYELDYVITDTLRGSVVDFFTVWLPAPTLSFLSVSDGFSGPDRMEALKGLLGSIPDNAFQRSPAGKDWNLIHRVASVLIGGLKLAGVGFISSIGAVASSNVVYAMRKVLNPALAVKHPIKRSPILKTAVVYACFLGTSANLRYQVIAGLVEHRISDKFSDQAFLVNMLSFVVRTINSYWGTQQWVDLARFTGLQAQKNEKVSSETSDSPKPAALECNAPEDANIDETNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V190</accession>
    <name>A0A068V190_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00038666001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V190"/>
    <dbReference type="STRING" id="49390.A0A068V190"/>
    <dbReference type="Gramene" id="CDP13648">
        <property type="protein sequence ID" value="CDP13648"/>
        <property type="gene ID" value="GSCOC_T00038666001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V190"/>
    <dbReference type="OMA" id="EATACGW"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V190"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000001">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 28, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="150" mass="16639" checksum="2EFA38D8761B84EC" modified="2014-10-01" version="1">MASKRIQKELKDLQKDPPASCSAGPVGEDMFHWQATIMGPSESPFSGGVFLVSIHFPPDYPFKPPKASVSFKTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYETTARSWTQKYAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3E8</accession>
    <name>A0A068V3E8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00040805001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. CGFS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739168">
        <property type="protein sequence ID" value="CDP14408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3E8"/>
    <dbReference type="FunCoup" id="A0A068V3E8">
        <property type="interactions" value="1555"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3E8"/>
    <dbReference type="Gramene" id="CDP14408">
        <property type="protein sequence ID" value="CDP14408"/>
        <property type="gene ID" value="GSCOC_T00040805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3E8"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658504" description="Glutaredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP14408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="228" mass="25239" checksum="0E29D17AE6AFB9ED" modified="2014-10-01" version="1">MGATILIVKKFSFVLQTLQALCLNPAPFHSPNSQTLHSLWVIFMVESLIHKSARTLWSLAAELGKSMAAVPAARSDASAATFFCRGVICYSTTVPNDPDTHEDFRPTIKLESSSLSLTDIVEQDVKEKPVMIYMKGVPDLPRCGFSSLAVRVLKEYSVPISARNILENVELKNAVKAYSNWPTFPQIFIKGEFIGGSDIILNMHQCFTRNGELKEKLKDIMGGSEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3R9</accession>
    <name>A0A068V3R9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00041048001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068V3R9">
        <property type="interactions" value="1990"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3R9"/>
    <dbReference type="Gramene" id="CDP14533">
        <property type="protein sequence ID" value="CDP14533"/>
        <property type="gene ID" value="GSCOC_T00041048001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3R9"/>
    <dbReference type="OMA" id="YTVYSQM"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3R9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000024">
        <property type="entry name" value="Serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000036">
        <property type="entry name" value="Serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="18">
        <location>
            <begin position="1661"/>
            <end position="2270"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="17">
        <location>
            <begin position="2380"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="19">
        <location>
            <begin position="2691"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="2723" mass="306212" checksum="9F388D9F44BD2D57" modified="2014-10-01" version="1">MANLSSLVHELRERIAASSSTPPTKQNDEALEARFRAVLPNLLHAYVVPSPSAKEREVMAVLKLLTHTAKSFPGVFYHGKAAAVLPIIGRIVPFFAEPAFRSRHGVLFETIGSLLSLLRTGDRDAYRNFFVDIMLLVEDLLYVCSLYGESCSTELEKVCLKCFNVSFAGACGEDALLSHVPASSKPADGYGILIDLTGKERWQPFATSAVKLLSKCLTEGTLYVEGLVYTPCVLAACSLICYGDDNLHIACFDFIRLIGAVMDFDIIPFEKLIQSMAIILGEDEYGLSTFRGTAYDSSLAACLCALYTSCPDDIVKSTASTFIKIFPESFLKTKSQELKAALCSAYVRIAKSCPPHIWRPENLIYLLRSDKSVFLLIDCFQVAISRLRLDFWGGGLANDCSVSSSGDNENKNLRTTEKRPAMDSEYTDSKRQKIVDEREDFITNCKGVHDVANKLITAGEREYADYMHSLLSLFVEDLAPPFEKASSLNPEVELAALIALCVVFCEYPQLNISLSIFRQFYKWIPWIAEQENKELPSPVDLSFFLEAVNIMLLTQGSLPSDGKLFKCQTDWTDFIGSMLKLPWIYSLERSEPHPSWKAKCLSVQVLSKIDLSKIGNNLDILDLSLHDQAEEVRLEAVISMPVIVLWSGYGFLTHMFKRLEILLLESNDKIKKAIPLSLGFLACLYGSCHGLGTWWESECKLYLNKQNRREKSTTHHLLRGFRCSKCDSRVVVNQDFCSTAVHPPGSSSMEHVIGCDYTCLQSLFFQLLYDESSEEVQVACIGILGRVLLHGTGDILQSTRSEWMNCVDFLLLHQKKAIREAFCTQISFFFEEPILNCLVLDMDLINKTKEQKFMDKIKHALAAADDPLMFETLLEAAANILISVNIKSQPFLMSLTLLIDQLDNPHVTVRITASTLIKSSCHFHFKGGLCTILSKVLHIRNELYDYLSTRLASRPEMIEEFAVAVLGIETEELVKRMIPVVLPKLVVFQHHNDQAIIILHEMAKCLKTDMVQLIVNWLPKVLAFSLNRADEQELLSTLQYYHDQTGSDNKEIFAAALPALLDELVCFIDEKDPEEVCKRLTQVPQTIKEVARTLTGDEDLPGFLRNHFVGLLNSIDRKMLHTEDVLLQKQAIKRIEMLINMMDTHLSTYVPKLMVLLMHAIRKEHLVGEGLAVLHVFIKQLVKISPSSTKHIISQVFAALVPFLERDKVNSSLHLNKIVEILEELMLQNKFLLKQHIHEFPPLPKIPALAELNKVIQEAQSPRSLKEQLLDVANGLNHENLNVRYMVASELGKLLNQRREEVTVLAIKEGNQNMDVLSSLFSSLLRGCAEESRTSVGQRLKLICADCLGAIGAVDPAKFVSSSSTRFKIACSDDDLIFELIHKHLARAFRAAPDTIIQDSAALAIQELLKIAGCEASLDENVAASTSERKNKPPRKAPASAIKTENHGTEICGRGQKLWDRFSDYVKEIIAPCLTSRFQLPDVSDSASSGPIYHPSMSFRRWIFFWIKKLTVHAVGSRASVFNACRGIVRHDMQIAMYLLPYLVLNAVCHGNEEARHGITQEILSVLDVAASDHGSVTVHGINPGQSEVCIQAVFTLLDNLGQWVDDIEQELALFQSLQPSNCKQQGPKSKENNMHLVKDSEVLTQCNHVSDLLAAIPKVTLARASFRCQASARSLLYFECHVRERSGSFNPAAEKSGFFEDDDVSFLMEIYSNLDEPDGLSGLACLRKSKNLQDHLLINKKAGNWAEVLTSCEQALQMEPTSVQRHSDVLNCLLNMCHLQAMVTHVDGLISRIPQYKKMWCMQGVQAAWRLGRWDLMDEYLTGADEEGLLCSSSESNASFDMDVAKILQAIMKKDQFLVAEKIASSKQALIAPLAAAGWDSYARAYPFVVKLHLLRELEDFNMLLAGDSFLDKQLYLSEPDFCKIIANWENRLKFTQPSLWAREPLLAFRRLVFGASGLGAQVGNFWVQYAKLCRLAGHYETANRAILEAKASGAPNVHMEKAKLLWSTRRADGAIAELQQSLLNMPEILGSAAMSSITSLSLVPLNPQPLLCDTQSLNENRDIARTLLLYSRWIHYTGQKQKEDVISLYSRVKELQPKWEKGYFYMAKYCDEVLVDARKRQENSFELPRVVPSNSVLSSAASNSERRWWSYLPDVLLFYARGLHKGHKNLFQALPRLLTLWFEFGCIYGSDSASNKDMKSVHAKVTSIMRGCLKDLPTYQWLAVLPQLVSRICHQNEEIVRLVKHIITSVLRQYPQQALWTMAAVTKSAVPSRRSAAEEIIDAARRGSSQGGTRSLFMQFATLIDHLIRLCLHPGQAKAKTINISTEFSALKRMMPVDIIMPIQQSLAVNLPSCEMNVTSPSTSDIFSFTDLPTISGIADEAEILSSLQRPKKVFLFGSDGTKRPFLCKPKDDLRKDARMMEFNAMINRLLSKCPESRRRKLYIRTFAVTPLTEDCGMVEWVSHTRGLRPILQDIYISCRKFDRQKTNPQIKRIYDQCQGKMPEEEMLKNKILPMFPPAFHRWFLNTFSEPAAWFRARVAYAHTTAVWSMVGHIVGLGDRHGENILFDSTTGDCIHVDFSCLFDKGLQLEKPELVPFRLTQNIIDGLGITGYEGIFLRVCEITLSVLRAHRETLMNVLETFIHDPLVEWTKSHKSSGIEVQNPHAQRAISNIEARLQGVVVGVGAAPSLPLAVEGQARRLIAEAVSHKNLGKMYIWWMPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5L2</accession>
    <name>A0A068V5L2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016638001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="HG739194">
        <property type="protein sequence ID" value="CDP15799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5L2"/>
    <dbReference type="STRING" id="49390.A0A068V5L2"/>
    <dbReference type="Gramene" id="CDP15799">
        <property type="protein sequence ID" value="CDP15799"/>
        <property type="gene ID" value="GSCOC_T00016638001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5L2"/>
    <dbReference type="OrthoDB" id="1680570at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5L2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM AAA-lid" evidence="2">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP15799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="81" mass="9493" checksum="FA43A81C33779805" modified="2014-10-01" version="1">MRISVANILILFDMYIHYCRTHCQPRLSESAAFVLQENYVKIRQDMRRQANETEEAATIPITVRQLEAVVRLSEALARMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V760</accession>
    <name>A0A068V760_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019088001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V760"/>
    <dbReference type="STRING" id="49390.A0A068V760"/>
    <dbReference type="Gramene" id="CDP16635">
        <property type="protein sequence ID" value="CDP16635"/>
        <property type="gene ID" value="GSCOC_T00019088001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V760"/>
    <dbReference type="OMA" id="CEQPPRN"/>
    <dbReference type="OrthoDB" id="783774at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V760"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040229">
        <property type="entry name" value="At3g27390-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31133">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31133:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="194" mass="21740" checksum="4AD42F4EEF28FA8F" modified="2014-10-01" version="1">MEPPRGFFASLWSFICFLPYFIGLLILGFIKGIFLCPLICLLMSVGNSAVTLGLWPVHLCYTYYCILSTKQLGPVLKLVLCPLVLVLLIFWPIIAVLGSILGGAAYGFFSPMLATFQAVGEGKTNQFFHCIYDGTWDTVKRSFTVVRDFLDMCYYSYFSIMDDLRVQGLSAGKYYEIRHGSLLLTVFSIELGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7X1</accession>
    <name>A0A068V7X1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyproline O-arabinosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00019103001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739219">
        <property type="protein sequence ID" value="CDP16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7X1"/>
    <dbReference type="FunCoup" id="A0A068V7X1">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7X1"/>
    <dbReference type="Gramene" id="CDP16647">
        <property type="protein sequence ID" value="CDP16647"/>
        <property type="gene ID" value="GSCOC_T00019103001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7X1"/>
    <dbReference type="OMA" id="EVGLQHK"/>
    <dbReference type="OrthoDB" id="2015991at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7X1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056508">
        <property type="entry name" value="HPAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23452">
        <property type="entry name" value="HPAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658657" description="Hydroxyproline O-arabinosyltransferase-like domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxyproline O-arabinosyltransferase-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxyproline O-arabinosyltransferase-like" evidence="9">
        <location>
            <begin position="411"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="837" mass="95463" checksum="C668144BB1BFF649" modified="2014-10-01" version="1">MMYLRVTLVVALLLLSGGGAAQREGAAHGVHKHQAPWRIHTLFSVECQNYFDWQAVGLIHSFKKSRQPGPITRLLSCTQEERKTYRGMDLAPTFEVPSMSRHPKTGDWYPAINKPAGIVHWLKHSKDAQNVDWVVILDADMIIRGPIIPWELGAEKGRPVAAYYGYLVGCDNILAKLHTKHPELCDKVGGLLVMHIDDLRALAPMWLSKSEEVREDRAHWATNYTGDIYGQGWISEMYGYSFGAAEVGLRHKINNNLMIYPGYIPLDGVEPILMHYGLPFRVGNWSFSKLDHHEDNIVYDCGRLFPEPPYPREVNQLETAPDKRRALFLNIECINTLNEGLLLQHATYGCPKPKWSKYLSFLRSKAFAELTGPKLLTPKTLQMMDEDRAQVVDEPHVQVVDEPIKPHPKIHTIFSTECNSYFDWQTVGLVHSFQLSGQPGNITRLLSCNDEDLKQYKGHHLAPTHYVPSMSRHPLTGDWYPAINKPAAVLHWLNHVKTDAEYIVILDADMIMRGPITPWEFKAARGRPVSTPYGYLIGCDNELAKLHTRHPEACDKVGGVIIMHINDLRKFALLWLHKTEEVRADRSHWSRNITGDVYESGWISEMYGYSFGAAELNLRHQISNEILIYPGYVPVPGVKYRVFHYGLEFRVGNWTFDKANWIHTDVVNSCGAKFPDPPDPSTLDHSDDDSLQRDLLSIECVKTLNEALHLHHERSKCNVHSPQTISNQDSSETTISRKFGKFEEVHNLTYNTTTTNNSQEISPPEEPNQTFSSMRFWIISLWAFSILGFVIIMSVMLSGRKGQKKRGKVYKPKRRSSYSGFWDTNGHDRHLRSGEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8G2</accession>
    <name>A0A068V8G2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00017265001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739202">
        <property type="protein sequence ID" value="CDP16178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8G2"/>
    <dbReference type="FunCoup" id="A0A068V8G2">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8G2"/>
    <dbReference type="Gramene" id="CDP16178">
        <property type="protein sequence ID" value="CDP16178"/>
        <property type="gene ID" value="GSCOC_T00017265001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8G2"/>
    <dbReference type="OMA" id="FTQWKFP"/>
    <dbReference type="OrthoDB" id="1930451at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8G2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058678">
        <property type="entry name" value="ARM_PUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47873">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47873:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25598">
        <property type="entry name" value="ARM_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="2">
        <location>
            <begin position="201"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP16178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="38519" checksum="88143FDBE1C81761" modified="2014-10-01" version="1">MKSQHPKLKTAPRPLFSCGFFRNCTQTVLSPTTTTPPALPFPATSDQPPLKPTSPPPPPPPPPPPPLPPPPSSSHPPHAPTKPDSESSSSSSNTSQSFTQWRFPLTNSPISHHLIHPYQQTQEKPKISEPTPPRKAPDSLPPPPPLSATKLEETFHVAELRFSSGSDEDKLGALHLLEKSLVPNPRAVADGGDAVACPATVMKWVVSCLKERVMAKSASKVLLALCLVEGNRHAAVEAGAVGVVVDAMADLEGAVAERSLAALELLCTVAEGAAELRSHALAVPMMVEVMGRMEGRGKEYAISVLAVIFGGCTDGAVVAPPEEVARAVMLALQGDCSARGRRKAAQLLKILQEENGRLDLTQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA81</accession>
    <name>A0A068VA81_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NBP35</name>
        <name evidence="10" type="ORF">GSCOC_T00007668001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 3 [4Fe-4S] clusters per homodimer. Contains two stable clusters in the N-termini and one labile, bridging cluster between subunits of the homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer and homotetramer. Predominantly homodimeric.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Although plant and algal NBP35 proteins lack the characteristic CXXC motif in the C-terminus, thought to be required for Fe-S cluster binding, they can bind a [4Fe-4S] cluster in the C-terminus. Also, in this linage, no CFD1 partner protein homolog as found in other eukaryotes can be found.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739245">
        <property type="protein sequence ID" value="CDP17464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA81"/>
    <dbReference type="FunCoup" id="A0A068VA81">
        <property type="interactions" value="2964"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VA81"/>
    <dbReference type="Gramene" id="CDP17464">
        <property type="protein sequence ID" value="CDP17464"/>
        <property type="gene ID" value="GSCOC_T00007668001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA81"/>
    <dbReference type="OMA" id="EMDCQVG"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA81"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP17464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="357" mass="38630" checksum="C3645D22A0AC20CE" modified="2014-10-01" version="1">MENGDYKDVPENANEHCPGTQSESAGKSDACKGCPNQEACATAPKGPDPDLVTIVERMATVKHKILVLSGKGGVGKSTFSAQLSYALAAMDFQVGLLDIDICGPSIPKMLGLEGQEIHQSNLGWSPVYVESNLGVMSIGFMLPNPDEAVIWRGPRKNGLIKQFLKDVYWGELDFLVIDAPPGTSDEHISIVQFLQATGIDGAIVVTTPQQVSLIDVRKEVSFCKKVGLKVLGVVENMSGLCQPLSEFRFMRTTETGEQKDMTEWILSYMKGKAPEMLDVVAYTEIFDSSAGGAGRMCSEMGIPFLGKVPLDPQLCKAAEEGRSCFSDEKCRVSAPALKMIIDKLLAQQMISRIEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB64</accession>
    <name>A0A068VB64_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aurora kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00003918001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB64"/>
    <dbReference type="FunCoup" id="A0A068VB64">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB64"/>
    <dbReference type="Gramene" id="CDP17794">
        <property type="protein sequence ID" value="CDP17794"/>
        <property type="gene ID" value="GSCOC_T00003918001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB64"/>
    <dbReference type="OMA" id="KNRPCIK"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB64"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="41"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP17794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="306" mass="35080" checksum="CD3B40673CF91EDA" modified="2014-10-01" version="1">MTSSSSQTQIQSQKPPRKPQPPPISTTTPTTSKRNWSLNDFEIGKPIGRGKFGRVYLAREVQSKYIVALKVIFKEQIGKHGLHRQLRREMEIQSSLHHPNILRLHGWFHDDLRVVLILEYAHGGELYRQLRKSGHFSEPQAAYYIASLTRALAYCHEKHVIHRDIKPENLLLDHEGHLKIADFGWSVQLKSESKRMTMCGTLDYLAPEMVDNQAHDYAVDNWTLGVLCYELLYGVPPFEAESQRDTFRRIMKVDLSFPSTASVSAEAKNLISRLLVKDSTKRLSLKEILEHPWVVKNAENTVACTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB66</accession>
    <name>A0A068VB66_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00001231001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant DMP1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739278">
        <property type="protein sequence ID" value="CDP17976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB66"/>
    <dbReference type="STRING" id="49390.A0A068VB66"/>
    <dbReference type="Gramene" id="CDP17976">
        <property type="protein sequence ID" value="CDP17976"/>
        <property type="gene ID" value="GSCOC_T00001231001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB66"/>
    <dbReference type="OrthoDB" id="657601at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007770">
        <property type="entry name" value="DMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621:SF5">
        <property type="entry name" value="PROTEIN DMP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621">
        <property type="entry name" value="PROTEIN DMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05078">
        <property type="entry name" value="DUF679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="168" mass="19146" checksum="68895DEA0424263C" modified="2014-10-01" version="1">MDLQPCLEQQQQSHANDSTPNGKPYCNSIQHPVHKTLATAANLANLLPTGTVLAFRTLTPSFSNKGRCQPSNKYLTAFLIGFCTVICFFSSFTDSFFDKHDGKLYYGIATFKGLYIFNNECRRDHDEKSEGEDMKELSEIKYGCFVHEFAFGSWDSLKLFVHYLSYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB73</accession>
    <name>A0A068VB73_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00005275001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739224">
        <property type="protein sequence ID" value="CDP16923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB73"/>
    <dbReference type="STRING" id="49390.A0A068VB73"/>
    <dbReference type="Gramene" id="CDP16923">
        <property type="protein sequence ID" value="CDP16923"/>
        <property type="gene ID" value="GSCOC_T00005275001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB73"/>
    <dbReference type="OrthoDB" id="1664327at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB73"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="68" mass="7922" checksum="0684B7626C7C17C9" modified="2014-10-01" version="1">MHANTRARRRSLSNLTRAFSRHGQENLNSEHNEFYCNLNAKLLHLAWHPNKDLIACAAGSSVFMHYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBE2</accession>
    <name>A0A068VBE2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00001628001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG739283">
        <property type="protein sequence ID" value="CDP18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBE2"/>
    <dbReference type="FunCoup" id="A0A068VBE2">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18046">
        <property type="protein sequence ID" value="CDP18046"/>
        <property type="gene ID" value="GSCOC_T00001628001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBE2"/>
    <dbReference type="OMA" id="MARFAHI"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBE2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000080">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF88">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="478" mass="53249" checksum="35604036841855EC" modified="2014-10-01" version="1">MKKAELVFVTVPGIGHLVSCVELAKLLVECDERLSITVLMMKQPFDSKVSSYTNSLLETPNLHIRYLELMKEEPSSQLSSFLSIFFRFIDNHKSCVRDVLAEISNSVSSHLGGIIIDMFCTSLIDVANEFGVPSYIFYPGGAATLGVLFQLQSLRDDLNEEVSYYENSDVELALPTYINPVPAKLLSSALFEKDGGVDMVLDQAQRYRKTKGIIINTFLELESHAIQALSNDKTIPPVYAVGPVLNLKGSNSQNQETEMIMKWLDLQPKCSVVFLCFGSGGSFDADQVKEIAYALEHSGYRFLWSLRTPSPKEKFEFPSEYENLDEVLPEGFLQRTAAVGKVIGWAPQAAVLSHPAVGGFVSHCGWNSILESVWCGVPVATWPLYAEQQENAFLMVKDLAMAVEIKIDFKRDFVMGVSSEILSADVIERGIKHLMDPENEIREKVKEMKEKSRLAPSEGGSSFSSLRRFLEDVADNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCH8</accession>
    <name>A0A068VCH8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00011998001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VCH8"/>
    <dbReference type="FunCoup" id="A0A068VCH8">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCH8"/>
    <dbReference type="Gramene" id="CDP18272">
        <property type="protein sequence ID" value="CDP18272"/>
        <property type="gene ID" value="GSCOC_T00011998001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCH8"/>
    <dbReference type="OMA" id="IPPDWLF"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCH8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000081">
        <property type="entry name" value="Exonuclease DPD1 chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="124"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP18272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="330" mass="37420" checksum="509113744A81B238" modified="2014-10-01" version="1">MCFSLLQFPRYRIHALANSWWETFPILNRRAGITSSFKVLGSGNYGPEGRQYRRYSRQIITMKTEGRKKDSLSSKGNIKDEILEEALSTNLNTHKSSVTDVERTQVLDIRQMIAENKELAKLVSFIVFDIETTGFSRTEDRIIEIALQDLAGGKNSIFQTLVNPKCYVPNSHVHGISTHMVNKPDVPRMEELIPILLQYIKSRQKPGGFVVLIAHNARNFDVPFLAEEFSRCSYKIPPDWLFVDTLPLAREAMKSKGFKGALKLSLQALGETFKIPLKGSAHRALADVQMLSLIFQKITFELKLSGSSIIEKYSFSDLELRNSKKKKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDY2</accession>
    <name>A0A068VDY2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00004311001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="HG739272">
        <property type="protein sequence ID" value="CDP17908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDY2"/>
    <dbReference type="STRING" id="49390.A0A068VDY2"/>
    <dbReference type="Gramene" id="CDP17908">
        <property type="protein sequence ID" value="CDP17908"/>
        <property type="gene ID" value="GSCOC_T00004311001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDY2"/>
    <dbReference type="OMA" id="NIPANSW"/>
    <dbReference type="OrthoDB" id="1295060at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDY2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF48">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP17908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="176" mass="19850" checksum="8EDEDD5DA3FC03D5" modified="2014-10-01" version="1">MSIYVPTDSCRSKPDSKCLEKNHESYPDLVKDGYQSYKEFKKKKKLKIKAKQNGNDLCSTSKARTISNEIIIEDLAAGESGGKVAAPGRKIKVFYTVRSRETGSLLESNLGEEKPFKFRLGDKKVIQGWNLGINGMRTGDRRRLIIPPSMVYGERAPDVFPSDSWLVYDIELVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEN7</accession>
    <name>A0A068VEN7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00000042001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739487">
        <property type="protein sequence ID" value="CDP19270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEN7"/>
    <dbReference type="FunCoup" id="A0A068VEN7">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEN7"/>
    <dbReference type="Gramene" id="CDP19270">
        <property type="protein sequence ID" value="CDP19270"/>
        <property type="gene ID" value="GSCOC_T00000042001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEN7"/>
    <dbReference type="OMA" id="NDICPTK"/>
    <dbReference type="OrthoDB" id="1916993at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEN7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34376">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, KAZAL-TYPE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34376:SF2">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, KAZAL-TYPE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655717" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14943" checksum="8CFD8983D0BCBD9F" modified="2014-10-01" version="1">MPLMSKSSKIQFIFLLLTVLFIAVRSSQFNPLLLPSDLAQNNNNNNNDGYDDHLCPRVTEPAPDSCPVKCFRTDPVCGVDGVTYWCGCADAHCAGTRVAKLGFCEVGNGGSGSVSGQALLLVHIVWLILLGIFVLFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG17</accession>
    <name>A0A068VG17_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003948001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739629">
        <property type="protein sequence ID" value="CDP19547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG17"/>
    <dbReference type="Gramene" id="CDP19547">
        <property type="protein sequence ID" value="CDP19547"/>
        <property type="gene ID" value="GSCOC_T00003948001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="141" mass="16198" checksum="9FE7CBB66C01D26D" modified="2014-10-01" version="1">MVNGEELKFNLVNKDGSIEPIALVSNMPRNERTNQEMNEEVKSINFFGTNFYGIGAREARLRTEIDLISSAFHESIREKSSQLEKGEQMLLQGAVEPLHDKSNTPPWHLRKLDDGDKCMAHHTVEWLGSFDPWEENHFPMS</sequence>
</entry>
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        </submittedName>
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        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>asterids</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068VGE0"/>
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        <property type="gene ID" value="GSCOC_T00008717001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGE0"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047627">
        <property type="term" value="F:adenylylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP19662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="131" mass="14300" checksum="9DDA508A4E05213C" modified="2014-10-01" version="1">MASEKEAALAAAALPADSPTIFDKIINKEIPANVVYEDDKVLAFRDINPQAPIHILLIPKVKDGLSGVSKAEERHIEILGRLLYTAKLVAKQEGLEDGFRLVINDGPSGCQSVYHLHIHLLGGRQMNWPPG</sequence>
</entry>
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    <accession>A0A068VGU6</accession>
    <name>A0A068VGU6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_796</fullName>
        </submittedName>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Magnoliopsida</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739880">
        <property type="protein sequence ID" value="CDP19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068VGU6"/>
    <dbReference type="Gramene" id="CDP19941">
        <property type="protein sequence ID" value="CDP19941"/>
        <property type="gene ID" value="GSCOC_T00007202001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VGU6"/>
    <dbReference type="OMA" id="VWMLHKL"/>
    <dbReference type="OrthoDB" id="1915848at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VGU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009959">
        <property type="term" value="P:negative gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF641_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040225">
        <property type="entry name" value="GIL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056813">
        <property type="entry name" value="GIL1_IRKI_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31161">
        <property type="entry name" value="PROTEIN GRAVITROPIC IN THE LIGHT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04859">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24994">
        <property type="entry name" value="GIL1_IRKI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF641" evidence="1">
        <location>
            <begin position="86"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GIL1/IRKI C-terminal" evidence="2">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP19941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="477" mass="53694" checksum="BADD7A23B62F590E" modified="2014-10-01" version="1">MVEMEGPSSARPPQISEMFQKFALAFKAKTFELFAEEGDDPTTTTAAAGAAEGDVFTLLDSAEEFIPDQKVVVLKPDPTFSPEINRTHVVQTLISSIFATISSFEASYLIFQAAHVPKIDQDGLESADKTLVSILQKLTDLRNVDRDFRKNPGGNFEAPAGSFLEFQVQENQSKLRALETMVNQLISDIECKDDQVLNLRKNLDKMVVFNSNLQKRLVAKNEQLNNGTEILLTVRVFESMLRDCVKSLHCFSKLLIDLMRKAGWDLTMAANSVYSNVDYAKEGHYKYAFLSYISLGMFRGFDLDDFLLNGNEVVCNGNNSIPSKDGCLKQLIQHVSSNPMEVLGKHSKCDFSRFCEQKYDQLIHPTMESSVFSNFDRKEAVLDSWKSLSVFYESFVRMASSTWMLHKLAYSFDPIVEIFQVERGVDFSMVYMEDVTQKTSPSGKSRRKVAFTVVPGFKVGRTVVQSQVYLTGTSCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH66</accession>
    <name>A0A068VH66_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00008042001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
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            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739942">
        <property type="protein sequence ID" value="CDP20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH66"/>
    <dbReference type="STRING" id="49390.A0A068VH66"/>
    <dbReference type="Gramene" id="CDP20051">
        <property type="protein sequence ID" value="CDP20051"/>
        <property type="gene ID" value="GSCOC_T00008042001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH66"/>
    <dbReference type="OMA" id="STRCITH"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH66"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF5">
        <property type="entry name" value="SNF2 DOMAIN-CONTAINING PROTEIN _ HELICASE DOMAIN-CONTAINING PROTEIN _ HNH ENDONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="200"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="611" mass="68817" checksum="7D876D8BAD982277" modified="2014-10-01" version="1">MKVKHLILLSGTPSLSRLPFDIFHQINMLWPGLLGETKYDFAKTYCSVKLVNGCQGKVFQDFSKGIRLEELNVLLKQTVMIRCLKQHVLAQLLPVRQKIMRLVLRRSNIASAMAALGLVLAKSYFTSFLAALGVLNSDTSANDTEDEFSELQFQVNDVHKDHYISSAFSEKHLIYNALQISKLLGFLECLSIHPMLSGFDGKEATEATVSSQKMTIFAHHNIVYDRIQEFLLEKGIEYIRIDAHVSFIGKEAIQSFQSSEQVKIAIIGISAGGFGLTLTAAKNVVFLELPKEISSLNQAESRAHRIGQMKAVKIYIFCAKWQKLIKSLFEVLAVMNGKHAAISEIKGENYNYEENNYNEVIEQHCYCNRTITMGGEWNWYCIISSGKPSQACPTLGCNAFSIRAISGTAGTISSYNLEDSEATDKDEEVQSILSAAYSFSVATGNLFRIYKLRIQGNQESGVELDSNASGAIEAALTSAVQVEYLRFEVSQYTGRIHLYSCIPGIDSRPRPLFLSFRPEEFESEDLYEDAMKKGKNCRQDVQRYQSALILFMKQWNHLRPIERRKLLVKPLQLPLSTELCYLMESLSHDIGGLLKCRSTRCITHLDEINSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHB4</accession>
    <name>A0A068VHB4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00007446001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739896">
        <property type="protein sequence ID" value="CDP19979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHB4"/>
    <dbReference type="STRING" id="49390.A0A068VHB4"/>
    <dbReference type="Gramene" id="CDP19979">
        <property type="protein sequence ID" value="CDP19979"/>
        <property type="gene ID" value="GSCOC_T00007446001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHB4"/>
    <dbReference type="PhylomeDB" id="A0A068VHB4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF111">
        <property type="entry name" value="NEPROSIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="83" mass="9108" checksum="1964944C612CE436" modified="2014-10-01" version="1">MGTDKLDSLHIGRQVDGSVKTGCFDATWPGFVQVSKDIALGAAIYPISNPTGLPSQITIFIFKDPNTGNWWVNYGESQYRIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI00</accession>
    <name>A0A068VI00_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00011258001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739494">
        <property type="protein sequence ID" value="CDP19293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI00"/>
    <dbReference type="FunCoup" id="A0A068VI00">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VI00"/>
    <dbReference type="Gramene" id="CDP19293">
        <property type="protein sequence ID" value="CDP19293"/>
        <property type="gene ID" value="GSCOC_T00011258001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI00"/>
    <dbReference type="OMA" id="VYPHQCK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VI00"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP19293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="374" mass="43067" checksum="CE6E4143F6806710" modified="2014-10-01" version="1">MKKGSGGAVADKKKARHASTSDTPPRKQAAKRDVFQLFAEKVRDHKDLESRWAVLQETRVEYFRGKDFLSFLRNHPELKNILESDRNLEVEDIANVLLRKNLLVRCDRVVKTVRPGKKKLSTWPAHLEIFPDQVFSDNDAFFAWTFVRRHPLWQTLLSFSWPVLTLAICLFPVYPHRCKLLILYSCASVLLLILCLLLLRALAFGAGWILLGKRIWFFPNILAEEATLKELFQFWPQKDEGEPPKWTARLFFAVVSVLVILLLKHHAPDEAARARYQKRVYNIIDDVLEWSPRLALSGMMEKQSVINATEANNFTEGGKSNPEEVVIPEDGQNISEDEAEEGIGVVESTDQHEFEEEIENVDDTDHQHQRNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIE2</accession>
    <name>A0A068VIE2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00012393001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HG740338">
        <property type="protein sequence ID" value="CDP20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIE2"/>
    <dbReference type="STRING" id="49390.A0A068VIE2"/>
    <dbReference type="Gramene" id="CDP20476">
        <property type="protein sequence ID" value="CDP20476"/>
        <property type="gene ID" value="GSCOC_T00012393001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIE2"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIE2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655835" description="beta-galactosidase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="5">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13669" checksum="8838BACD8E0DA9E7" modified="2014-10-01" version="1">MRGTTTMVLFLFIIVFLSAVLALFATNVTFDHRTLVIDGRWKVLISGAIHYPSSTPQVRAALLSWNQKSKYGGLDVIETYVFWNMHEPVRGQVSSFWLSFQLCFASVEILCCSHYKKIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIX2</accession>
    <name>A0A068VIX2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00007625001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740415">
        <property type="protein sequence ID" value="CDP20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIX2"/>
    <dbReference type="Gramene" id="CDP20539">
        <property type="protein sequence ID" value="CDP20539"/>
        <property type="gene ID" value="GSCOC_T00007625001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIX2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="64" mass="7216" checksum="31D1D5665DDED8E3" modified="2014-10-01" version="1">MFCASSCSHGLESHNTALERERLINYQIPIAGTESFKSANLLHVIYFSRPSAQIFFSVGYSQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJC0</accession>
    <name>A0A068VJC0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00006616001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739754">
        <property type="protein sequence ID" value="CDP19768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJC0"/>
    <dbReference type="STRING" id="49390.A0A068VJC0"/>
    <dbReference type="Gramene" id="CDP19768">
        <property type="protein sequence ID" value="CDP19768"/>
        <property type="gene ID" value="GSCOC_T00006616001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJC0"/>
    <dbReference type="PhylomeDB" id="A0A068VJC0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF102">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE JMJ31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin-like" evidence="3">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP19768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="109" mass="12629" checksum="DC67641AA34A7701" modified="2014-10-01" version="1">MSTLDTRLGCFFCFLFLFFLFLHLYLELFKQLFVSLICTEKVQLECLREDVEMPPFLESVTISSINLWMNSAQSRSSTHYDPHHNLLCIVSGCKQGLIFYGSSSLVFQL</sequence>
</entry>
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    <accession>A0A068VJK8</accession>
    <name>A0A068VJK8_COFCA</name>
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        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_1974</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00003321001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP20896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068VJK8">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VJK8"/>
    <dbReference type="Gramene" id="CDP20896">
        <property type="protein sequence ID" value="CDP20896"/>
        <property type="gene ID" value="GSCOC_T00003321001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJK8"/>
    <dbReference type="OMA" id="WREQVEF"/>
    <dbReference type="PhylomeDB" id="A0A068VJK8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
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    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="222"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP20896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="307" mass="34904" checksum="BCE8FBA97216E39E" modified="2014-10-01" version="1">MESGMINLGSSLKVPYVQELAKEKFASVPPRYIRPDPTKLHGVSTEEIPVIDMQRLLSDESVNPELEKLHFACKEWGFFQLINHGVSSSLVDKLKLEMQKFFNLTIEEKKRFAQEPGDVEGYGQAFVVSEEQKLNWGDMLFMVALPTHLRKPHLLPNLPLPFRETLDKYSRELKILAIKALEQMTKALGMELEDMTMLFQEGLQSMRMNNYPPCPQPCPQPVVPLPNAFIVNVGDILEIVTNGIYKSVEHRATVNLHNERLSIATFFSPKLDGDMGTAPSLITPENPAIFRRISMCRNITHRITTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJZ8</accession>
    <name>A0A068VJZ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00006525001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741404">
        <property type="protein sequence ID" value="CDP21026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJZ8"/>
    <dbReference type="Proteomes" id="UP000295252">
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="49" mass="5496" checksum="7ADCBFAA1453E000" modified="2014-10-01" version="1">MDLLGSSLEDLFNFCSRMLPLKTVLMLADHIVVSLFLICLLKMSLSLPL</sequence>
</entry>
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    <accession>A0A068VKW7</accession>
    <name>A0A068VKW7_COFCA</name>
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        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_2814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00002401001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="GSCOC_T00002401001"/>
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    <dbReference type="OMA" id="PLEMACH"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKW7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF588">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="147" mass="17064" checksum="A8CA2F4EED1A7057" modified="2014-10-01" version="1">MCNSCDVSQYYNHKLKEAVVQLQCELPDAATTYVDIYSIKYDLISHARKYESDFLYLKKWSYGVKMEFNYDPNFLCSEMVTLHYIETIVGSCGDSSVRVNWDGIHYTEAVIHWFFERIIDGSYSDPPIPLEMACHSQMEMSLLAQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN98</accession>
    <name>A0A068VN98_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_11314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00012937001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG750398">
        <property type="protein sequence ID" value="CDP22161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN98"/>
    <dbReference type="STRING" id="49390.A0A068VN98"/>
    <dbReference type="Gramene" id="CDP22161">
        <property type="protein sequence ID" value="CDP22161"/>
        <property type="gene ID" value="GSCOC_T00012937001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN98"/>
    <dbReference type="OMA" id="MHEDVNT"/>
    <dbReference type="PhylomeDB" id="A0A068VN98"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP22161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="71" mass="8198" checksum="885B44DCFFF0346C" modified="2014-10-01" version="1">MGLLSIIRKIKRKEKEMRILMVGLDNYGKTTIVMKMNGEDTSVISPTLGFNIKTIIYEKYSSCFSKFLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNE2</accession>
    <name>A0A068TNE2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00014831001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNE2"/>
    <dbReference type="FunCoup" id="A0A068TNE2">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNE2"/>
    <dbReference type="Gramene" id="CDO97479">
        <property type="protein sequence ID" value="CDO97479"/>
        <property type="gene ID" value="GSCOC_T00014831001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNE2"/>
    <dbReference type="OMA" id="WGFKGHV"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNE2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000001">
        <property type="entry name" value="probable beta-D-xylosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000004">
        <property type="entry name" value="probable beta-D-xylosidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF14">
        <property type="entry name" value="BETA-D-XYLOSIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="7">
        <location>
            <begin position="630"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="706" mass="76035" checksum="23D88CE28669E2F4" modified="2014-10-01" version="1">MLTLQEKVANLVDGAAGVSRLGIPKYEWWSEILHGVSNTGPGVHFTSLVPGATSFPQVILTAASFNKSLFEIIGKVVSTEGRAMYNVGLAGLTYWSPNVNIFRDPRWGRGQETPGEDPTLTSNYAAAFVRGLQQRDDGDKDRLKVASCCKHYTAYDLDNWKGIQRYTFNALVTQQDLDDTFQPPFKSCVLDGNVASVMCSYNQVNGKPTCGDPDLLSGIVRGKWNLNGYIVTDCDSLDVIFNNQHYTKTPEETVALTLNAGVDLNCGSFLAKNGVSAVNKGLVNESVIDRALTNNFATLMRLGFFDGDPKKQLYGNLGPKDVCTPENQELAREAARQGIVLLKNTAGSLPLSPAVIKSLAVIGPNAQATHTMLGNYEGVPCKYVTPLQGLSASVSTVFQAGCSDVSCATAQVDEAKKIAAAADAVVLVMGSDQSIETEGRDRVNITLPGQQSLLISEVASVSKGPVILVIMSGGGWDVQFAKDSPKITSILWVGFPGEAGGAAIADVIFGLHNPSGRLPMTWYPQSYVDKVSMTDMHMRPDPATGYPGRTYRFYKGQTVYSFGDGLGYSTFTHSLVQAPKVVSVPLEEGHVCRSSSSTCKSIDAVEQSCKNLGFNIHLRVRNVGTMSGSHTVLLFSSPPSVHNAAQKHLLGFQKLHLAPQTEGLVKFNVDVCKHLSMVDELGNRKVAVGEHVLHAGDLKHTLTVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNV9</accession>
    <name>A0A068TNV9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00021880001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TNV9"/>
    <dbReference type="FunCoup" id="A0A068TNV9">
        <property type="interactions" value="967"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TNV9"/>
    <dbReference type="Gramene" id="CDO97931">
        <property type="protein sequence ID" value="CDO97931"/>
        <property type="gene ID" value="GSCOC_T00021880001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TNV9"/>
    <dbReference type="OMA" id="SRCPDNM"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TNV9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDO97931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="275" mass="31099" checksum="12F370FA1E773398" modified="2014-10-01" version="1">MAAGIVVVFDFDKTIIDLDSDNWVLDELGFTDLFNQLLPTMPWNSLMDNMMGELHANGKTIQDIEEVLKRVPIHPRIVPAIKSAHALGCDLRIVSDANLFFIETILNHLGIRGCFSEINTNPGYVDENGRLRILPYHDFHSASHGCDRCPPNMCKGMVMERIQASIAKEGKKRFIYLGDGIGDFCPSLKLKEGDYMMPRKNFPVWDLICKNRMLLKAEIHEWNDGEDLERLLLQLINSIFAAEESLSQLLSTDCKFQTIPMSVHQALPQALSVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ89</accession>
    <name>A0A068TQ89_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00022605001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ89"/>
    <dbReference type="FunCoup" id="A0A068TQ89">
        <property type="interactions" value="2946"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ89"/>
    <dbReference type="Gramene" id="CDO98490">
        <property type="protein sequence ID" value="CDO98490"/>
        <property type="gene ID" value="GSCOC_T00022605001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ89"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044255">
        <property type="entry name" value="Dr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47173">
        <property type="entry name" value="PROTEIN DR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47173:SF2">
        <property type="entry name" value="PROTEIN DR1 HOMOLOG ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO98490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="161" mass="17955" checksum="D7C57FB6F5CBF644" modified="2014-10-01" version="1">MEPMDIVGRTKEDASLPKATMTKIIKEMLPPDVRVARDAQDLLIECCVEFINLISSESNEVCSKEEKRTIAPEHVLKALEVLGFGDYIEEVHAAYEQHRNETMDTVRAGKWSNGAEMTEEEALAEQQRMFAEARARMNGGAIVPPTVPKQPDSEPEPSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQJ9</accession>
    <name>A0A068TQJ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress up-regulated Nod 19 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022339001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQJ9"/>
    <dbReference type="FunCoup" id="A0A068TQJ9">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQJ9"/>
    <dbReference type="Gramene" id="CDO98292">
        <property type="protein sequence ID" value="CDO98292"/>
        <property type="gene ID" value="GSCOC_T00022339001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQJ9"/>
    <dbReference type="OMA" id="YLAACCD"/>
    <dbReference type="OrthoDB" id="1923469at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQJ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011692">
        <property type="entry name" value="Stress_up-reg_Nod19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33390">
        <property type="entry name" value="STRESS UP-REGULATED NOD 19 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33390:SF1">
        <property type="entry name" value="STRESS UP-REGULATED NOD 19 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07712">
        <property type="entry name" value="SURNod19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654110" description="Stress up-regulated Nod 19 protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51078" checksum="2606EE2FDA8C1DBE" modified="2014-10-01" version="1">MAKGSKCQFIFLATLLLVDTIQSFLMSETDENEVKTLVYLSPKFELGPGSVINKYYYDIDFPRGHIAVKSFDAEVIDEAGNSIPLYETYLHHWVAVNYYQRRGVETPKYHSRVGFQKSDYISAGNNGVCAQVLSQFFGLGSETRKTSNNVPDPYGIEFGNPAVIPAGYDEKWLLNVHAIDTRGAENRLGCTECRCDLYNVTVDEYGHNLDPSYVGGLRCCYDETRCRLKEGFQGVKRSLYLKYTVTYVDWHSSIGAVRVYIFDVTDRWKKSDGISSRHDCLIEYDVESCPAGVTKGGCVHTKSVSIILPAGGNVIYGVAHQHTGGVGSTLHGEDGRVICSSLPIYGEGKEPGNEAGYIVGMSTCYPQPGSVKISNGETLTVKSYYSSEQGHTGVMGLFYILVADSDSSAKLNSSQHAPVGIHKRVLTLDFIVGMALLGIAVLAAVIVAYQRRNQRGDNYEPITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQK3</accession>
    <name>A0A068TQK3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015043001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQK3"/>
    <dbReference type="FunCoup" id="A0A068TQK3">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQK3"/>
    <dbReference type="Gramene" id="CDO97643">
        <property type="protein sequence ID" value="CDO97643"/>
        <property type="gene ID" value="GSCOC_T00015043001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQK3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQK3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048316">
        <property type="term" value="P:seed development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000922">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052308">
        <property type="entry name" value="PPR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47937:SF2">
        <property type="entry name" value="PENTATRICOPEPTIDE (PPR) REPEAT-CONTAINING PROTEIN, PF01535'-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47937">
        <property type="entry name" value="PLASTID TRANSCRIPTIONALLY ACTIVE CHROMOSOME 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="783"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO97643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="93156" checksum="3F24F564ABC8D8DD" modified="2014-10-01" version="1">MYRTLLRHCRRSTCTSTAGTAHILSLKSQHLPQNPNQLIALRSYAFTSAEEAAAERRRRKRRMRIEPPMWALRRDPPSHSQQGSAPKGPPMPDSTSALTGPRLNLHNRVQSLIRAGDLDSASAIARHAVFSNVRPTVFTCNAIIAAMNRAGRYTDSKNLFQYFFKQSSIIPNIVSYNNLVLSHFGNGDVEEATNVYHLIYQEAPFLPSSFTYRHLTKGLIDAGRIDEAVSFLRDMLAKGQGADSLVYNNVIYGFLELGNLDRANEFFEELQERCLVYDGVVSATFMDWFFKQGREKEAMEAYKYLMNKQFRMVPATCNVLLEVLVRHGKEKEAWELFNNMLDNHTPPTFQAVNSDTFNIMVNECFRLGKVSEAVEVFKKVGKAEKSRPFAMDVAGFNNMIVRLCEVEKLEEAEGYFVQLQSKSLSPDVTTFRTFIDAYIQAGKVGETLEKYRMMVVAGLRVIPAYANKWFSFLIEKGKVEECVPILMKMCEREPKPDVTTFEIVIRGLCGVGELEACSYVVTQMITFGVGVTPALKEFLLHVFEKEGRLEVIERIVNARFPFYPPPQVPASQMPGQVPAWRVPLATPQSGMTSFSLSPQIPTQVPPAGPQSPWQSSVSPQLPSQAAAGATQMSWQASASSEMPGQSPAGASQMPVQASFTAQAPRAAQGPWRASVSSHNPGQTSPAASQMPWQASSAAQTQAPRTSEMPWQASVYSRMPEHASFPSHSPGNTPGASHMQWQQPPGASQMQWHTSSPQAPGASHVPWQTSSSPQAQGASPMTWQASSSPQAPASSQMSWQTASSAQATGAAQMPWQTSSSPQMPEQAAAPSQMPEQVVTHQMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR89</accession>
    <name>A0A068TR89_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022572001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR89"/>
    <dbReference type="FunCoup" id="A0A068TR89">
        <property type="interactions" value="3423"/>
    </dbReference>
    <dbReference type="Gramene" id="CDO98469">
        <property type="protein sequence ID" value="CDO98469"/>
        <property type="gene ID" value="GSCOC_T00022572001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR89"/>
    <dbReference type="OMA" id="EANLEHW"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="27"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="668" mass="75387" checksum="B844B44C4DCAC04D" modified="2014-10-01" version="1">MSRSLSFHARSEPDAKVDEKAFQQWAVAFCIIRFDLEQGQLIEECYPPGCLTQNEELEVAFSSFPDSVSQQYNRSSIHDCIFFFRIRRQEKMQTANVVSHEIVEVDNEIASQDNKLLKLSNNAPRYLYGFVFNRQRHDERLKRGGEQKSVVILSHSPYSSVFRPLLQIMGPLYFDIGKKALDYIAASVSSWASPLPGQLMELPIGNATLKVHLPPAHSLPLDGRMFFEELTSPIAPFLPSNQSVPQGLFHDSDLFGIFRGLLMQLWRLWELLLIGEPILVIAPTPPQCSEAVAGLVSLVAPLLCSVDFRPYFTIHDPEFAQLNSLQEGATFPPMVLGVTNLFFLKALRNVPHIVSVGSPASNSNRLAMSSRTSIGKMPDGQDGFGLPQLSLKKFTPSNFLNAVKLRRDGPLCLMTEHREAVWSTYTAITKPDTSILNRLIDAGMSPRVEESMSVVNNEILRRHFLELTTNFLAPFGPYFRATTPSEGSSPFLDPPPLPHFDKEEFLASLSARGPGKFLLKRMRSNWLDLYRRFMKGHNFLPWFRRKRAVAEQEQLRLWRQVRMKTDIKKFMSQLSEVEIVDSFNAIERHLLGELQQSGSANANVDSEAAHQKLKGDLLAVFNMLPKDVQELLLMNPHRAALLQGPPDCEDLPKEPLVQSAVLFSSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TT44</accession>
    <name>A0A068TT44_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026603001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TT44"/>
    <dbReference type="STRING" id="49390.A0A068TT44"/>
    <dbReference type="Gramene" id="CDO99431">
        <property type="protein sequence ID" value="CDO99431"/>
        <property type="gene ID" value="GSCOC_T00026603001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TT44"/>
    <dbReference type="OMA" id="MENTHDI"/>
    <dbReference type="OrthoDB" id="1918565at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TT44"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd22162">
        <property type="entry name" value="F-box_AtSKIP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278:SF116">
        <property type="entry name" value="F-BOX PROTEIN PP2-B10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="268" mass="30218" checksum="D6AB568C0EAF77F4" modified="2014-10-01" version="1">MEGPFARLPEGFISEILSLTSPVDVIRASVVSKGFKPAADSDTIWEKFLPSDYQDIISRSDSAVDCSTKKALYFSLCDSPLLLDGGRMSFSVDKRSGKKCYMVGARELIIAWARDPWYWHWISRPDSRFREVAKLKAVCWLDIRGRIESQMLSTGTTYAAFLVFKIAEEHYGIEKATSLIRFVNHESDGEAKRRAAPVHLVSREGMNHPAEFGGKFPKMRTDGWMELELGKFYTDRGDDGQVEARLIEIISLHGKSGLIVDGIEFRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU09</accession>
    <name>A0A068TU09_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029374001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU09"/>
    <dbReference type="FunCoup" id="A0A068TU09">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU09"/>
    <dbReference type="Gramene" id="CDO99701">
        <property type="protein sequence ID" value="CDO99701"/>
        <property type="gene ID" value="GSCOC_T00029374001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU09"/>
    <dbReference type="OMA" id="WCIPSVF"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU09"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF242">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN CXXS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="125" mass="13924" checksum="AEB6DDFA030B2E20" modified="2014-10-01" version="1">MEGQEHQSKSRVVKVDSLESWNFHVNQATTRGNPIVAHFSASWCMPSVAMNPFFEELASDFQDVSFLSVDVDEVKEVATKYEVKAMPTFLLIKEGAPVDKLVGANPDEIRKRIESLVQSTPAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVD3</accession>
    <name>A0A068TVD3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032040001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVD3"/>
    <dbReference type="STRING" id="49390.A0A068TVD3"/>
    <dbReference type="Gramene" id="CDP00176">
        <property type="protein sequence ID" value="CDP00176"/>
        <property type="gene ID" value="GSCOC_T00032040001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVD3"/>
    <dbReference type="OMA" id="GQRVINM"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000530">
        <property type="entry name" value="probable receptor-like protein kinase At5g59700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000608">
        <property type="entry name" value="Serine/threonine kinase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051564">
        <property type="entry name" value="LRR_receptor-like_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043891">
        <property type="entry name" value="SPARK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19160">
        <property type="entry name" value="SPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654251" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="306"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="589" mass="64733" checksum="21C93124B2344233" modified="2014-10-01" version="1">MKSLSQHALLVYLLVLSCTIVSSIARGPDGNCIIGIQNSSPGRNSNCRNGSWDGFLTNNCCEIPFKGYLYGLAQRANQSGQIFLNSTEQNDCLSSMKNSDPDAFDCGIQKLTNGLGGCSDYSVTDIDTKLGNRLNSLSESCKLVGSDGGSDQYCNQCSMSWRGMNTSSNSSNEMRNSQPDNCRFAVLISLISQRINDDHWFQAISNCLEDGSPNIGNSKFEVNFNHLMHLQKSCVVSKLLLVADFWILIGGVVGIAAIVTIACFVLLRKNTKGSPQGNEVSDNSLDGESRCVTISIKEVYSATNNLSDLNLIGQGIAGKVYKGILSDGQRIAVKHIINDGHMDTFVREVKSLSHIKHPNLVALLGHCDGDDECFLVYELCHNGNLSQWLFGKEKTLSWIQRLNIAIDCGRGLCFLHTYPGGCIVHRDIKPTNILICANFQAKLSDFGLSKVMSMGQSFVSSEVRGTFGYVDPEYRKNRHVNSSGDVYSFGIVLLQLLSGQRVINMDLQKPVHLNKVAKSVIRGGNMTEFADSKLHGDYSFEAFELVFKLALSCTGLKQQRPRMKHVVGRLEEALDISMRANSVSPTFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVY3</accession>
    <name>A0A068TVY3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029113001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVY3"/>
    <dbReference type="Gramene" id="CDO99508">
        <property type="protein sequence ID" value="CDO99508"/>
        <property type="gene ID" value="GSCOC_T00029113001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVY3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="125" mass="13774" checksum="E56EBD169733524C" modified="2014-10-01" version="1">MGGERKNRCVKYASPHILFVFLFLLLPIPVPHQKHTHNTHNPIICSLLLSLSLSLSLSIPNKVSAAVGTKTESCSSQKVHRFSQILQPPAPDDASITNSYLIAYHCSLSAGRHFFQTFNSFPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWB5</accession>
    <name>A0A068TWB5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00032235001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWB5"/>
    <dbReference type="STRING" id="49390.A0A068TWB5"/>
    <dbReference type="Gramene" id="CDP00332">
        <property type="protein sequence ID" value="CDP00332"/>
        <property type="gene ID" value="GSCOC_T00032235001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWB5"/>
    <dbReference type="OMA" id="IGQMKME"/>
    <dbReference type="OrthoDB" id="772197at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWB5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012870">
        <property type="entry name" value="DUF1666"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46741:SF4">
        <property type="entry name" value="FINGER FYVE DOMAIN PROTEIN, PUTATIVE (DUF1666)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46741">
        <property type="entry name" value="OS09G0413600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07891">
        <property type="entry name" value="DUF1666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="94659" checksum="9E027F248BBD98BA" modified="2014-10-01" version="1">MARQVFFTLKSRFSFVDERFLNELLHRTMFRYGHFLWVWLCNFMLNIFWLMVKYTHRVNADEAQENVSKFNVNHSQEDGEVISKTSMGFDSDFTTQKESSNLTFSLRSQKSADSKEQTAETEDSAFLQSGFRSSTRKYQFMAAGNLREFMEEPEIRSFTIQEMFEGSDDGLIQNSDGRVIQDEDEIKSSSEVQDLDRCSNASSNGDGLLIELRYDKRDDIEESTTKEETPEEEIADHLLETPFSEEILESKQRESSAQNKVSTYEELDDEISYEVQLLQRDDSSDCFSEPELENSFDESLAGNHEVPSRITEVPSSDAKDSEIFASTSPMISNIDRNPEISERCSSGKEVINGNLCTVGEADDDIEDDYIELEPRSKDANKADETILSRKDESLFELAHAGGKETQLMDDRPQNFQEESLGKESWESNSDDEDEFDILLEHQQLVKQMKMERKNSMARGLPTISENEDCETPKVLDYLKPLKIDEKFEYKDLMEEIQKFYKSYAEKTRKLDILNYQTLHAISFLQHKDSQLFIPSKRSLLSSIKPFSLPSISMSKQRRIYADPTLKSITEMHRDLELVYVGHICLSWEILQWQHGKVKELLEYDSQGNHCYNQVAGEYQQFQVLVQRFLEDERFNGPRIQHFVKSRCACRGLLQVPIIKDDCFKDKKETTGDEIDAISISMLAQTLKESMHIFWEFLRADKEEADGILKSVQGSLADPRAAVDSELLTNVRTRLEKKERKLKDIQRSVNCIVKRFQKQQAGQTSNALLISQVELKLVSRVLSLPRLTTDHLIWCQKKLDNINIVNRKICVEPAFLLFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX03</accession>
    <name>A0A068TX03_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00032821001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739089">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX03"/>
    <dbReference type="Gramene" id="CDP00751">
        <property type="protein sequence ID" value="CDP00751"/>
        <property type="gene ID" value="GSCOC_T00032821001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX03"/>
    <dbReference type="OMA" id="VEHDMIS"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX03"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000394">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994:SF5">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="61"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="215" mass="24087" checksum="B3511D39F5AAE489" modified="2014-10-01" version="1">MRKPCCDKEGMNKGSWSPQEDQELMDYIQKHGEGHWRNIPKATGLLRCGKSCRLRWVNYLRPDLKRGNFAEDEEDLIIRLHALLGNRWSLIAGRLPGRTDNEVKNYWNSHLSKKLASVGIDPKHHRLSHHLARNLINSIATGETSSALEHHQPFPLDHDQIKSSSASDHYQASDAGDGINDDDDSSSLLPDLNVDMASDSSLPSGTATEDKMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY89</accession>
    <name>A0A068TY89_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00034745001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY89"/>
    <dbReference type="Gramene" id="CDP01186">
        <property type="protein sequence ID" value="CDP01186"/>
        <property type="gene ID" value="GSCOC_T00034745001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="114" mass="12787" checksum="7E7426A67F1843FE" modified="2014-10-01" version="1">MRGTLEYLKSFSAFLYFQEQLESNLVRSYHPKILEGTILSSPKEGQSSQRSTEALNWLPDGCYNGLTLDSPIVNVDTRDDISTPCVPLEESSCNLNLGNMKDGKFQTSVNQNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYJ9</accession>
    <name>A0A068TYJ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 5B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00034983001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYJ9"/>
    <dbReference type="FunCoup" id="A0A068TYJ9">
        <property type="interactions" value="3262"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYJ9"/>
    <dbReference type="Gramene" id="CDP01370">
        <property type="protein sequence ID" value="CDP01370"/>
        <property type="gene ID" value="GSCOC_T00034983001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYJ9"/>
    <dbReference type="OMA" id="KDMECTP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYJ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP01370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="91502" checksum="D3CF44906B014178" modified="2014-10-01" version="1">MDTAMGEAEAGEILPERTIDMSAAYELLHKSKASVEEIVAQMLSIKKDSQPKSQLRELVTRIFLNFVALRQANRSILIEEDRFKAETERAKAPVDFTTLQLHNLMYEKNHYVKAIKACKDFKSKYPDIELVPEEEFFRDAPEDIKSSVISNDTAHNLMLKRLNFELVQRKELCKLRERLEQQKKALQETISNRKKFLSSLPSHLKSLKKASLPVQHQLGILHTKKLKQQQSAELLPPPLYVVYSQLVAQKDAFGENIDLEIVGSLKDAQAFARQKATKDSGISTNLETSRLDDDVPDEEDDGQRRRKRPRKVVSKDNLDQAGLYHSHPLKLLLHIHDDDASDSNSPKLISLKFEYLMKLNIVCVGIEGSQEGPENSILCNLFPDDSGLELPHQSAKLRLGDSFKLDPNRTSRPYKWAQHLAGIDFLPELSPLLTSHEASNEETAKHAAVLSGLSLYRQQNRVQTVVQRLRARKKAQLALAEQLDSLVKSKWPALTCGSVPWASRSPQCSLHDWSLIGSSPNHTPSLPVSDVEQVQGPDAEIGGKSGVSNRVVENLQEDGELPSLMSITAVINDVKLTPSKGSDLNLPRRLPLISKSILSPANKGKSPSFKRHDEDIDLILDSESELDEPAVVEPETDNAPVSRAIDMVESSWADCGVQVYRLTLLRTLNNGEKNFKLEAKIKIGLEYPLRPPLFALKLYCKLHEANYCEVDLSEWFNELRAMETEVNVHIIKSIPLDQENLVLAHQVHCLAMLFDFYMEDGDSSVKKRESTSVIDVGLCKPVSGALVARSFRGRDRRKMISWKDNICTPGYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZ80</accession>
    <name>A0A068TZ80_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00034774001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZ80"/>
    <dbReference type="STRING" id="49390.A0A068TZ80"/>
    <dbReference type="Gramene" id="CDP01204">
        <property type="protein sequence ID" value="CDP01204"/>
        <property type="gene ID" value="GSCOC_T00034774001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZ80"/>
    <dbReference type="OMA" id="CHRTAYL"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZ80"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20543">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20544">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000069">
        <property type="entry name" value="Cyclin-D5-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="87"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP01204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="335" mass="37742" checksum="024B77F29DE42EBE" modified="2014-10-01" version="1">MQNSQDAFSSPSSLLCREESENVLNDGGGTIGDYISTAGKEEDDDDDAEYVEMLLREEISGNGPVLQEQECAYISNWIKEARLDAIQYILSTNASFGFKIQTAFLAVTYLDKFLSRRLIEGEKYWAIRLLAIACLSLAAKMEECRVPLLSEFPGEDYNFEGKVIRRMEILILDRLEWRMAIATPYTFTPYFVSKLCKNNQMRDAVSRVIEIIPVAIRNANLIHDRPSTIAAAATLWMLDQRLSRESLELKINALSSSGFLKIEDIISFYNQMKELDTSSSIRSPPLTPIQLRRTSNDVLENSSIASSGLSAKRKSLTFTDEGDQNVKMPDSKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZJ3</accession>
    <name>A0A068TZJ3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 13">Alpha-amylase</fullName>
            <ecNumber evidence="4 10 13">3.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">1,4-alpha-D-glucan glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00034968001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 10 13"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZJ3"/>
    <dbReference type="FunCoup" id="A0A068TZJ3">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZJ3"/>
    <dbReference type="Gramene" id="CDP01359">
        <property type="protein sequence ID" value="CDP01359"/>
        <property type="gene ID" value="GSCOC_T00034968001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZJ3"/>
    <dbReference type="OMA" id="CVVIMSN"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZJ3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009739">
        <property type="term" value="P:response to gibberellin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd11314">
        <property type="entry name" value="AmyAc_arch_bac_plant_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012850">
        <property type="entry name" value="A-amylase_bs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013775">
        <property type="entry name" value="A-amylase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07821">
        <property type="entry name" value="Alpha-amyl_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001028">
        <property type="entry name" value="Alph-amls_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00810">
        <property type="entry name" value="Alpha-amyl_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010605221" description="Alpha-amylase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="14">
        <location>
            <begin position="27"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal beta-sheet" evidence="15">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001028-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="428" mass="47567" checksum="ABACA05E7E50A07F" modified="2014-10-01" version="1">MKNLMISLAYFFLIAGVCFFPNVAAQTLLFQGFNWESSNKQGGWYNFLLNEISDLASAGVTHVWLPPPSHSVAPQGYMPGRLYDLDASKYGNKQQLKTLIKAFHDKGIKCVADIVINHRCADKQDSRGIYCIFEGGTPDDRLDWGPSCICKDDVQYSDGTGNPDTGDGFGGAPDIDHLNSRVQRELSDWMNWLKSDIGFDGWRFDFVRGYAPSITKIYMQNTKPGFAVGELWDSLSYGQDGKPDYNQDGHRNRLAQWVQNGGGAVTAFDFTTKGILQVAVQGELWRLKDSNGNPPGLIGILPQNAVTFIDNHDTGSTQKLWPFPSDKVMQGYAYILTHPGIPSLFYDHLFDWGLKDGITKLSTLRIRNGITATSKVQILASDSDLYVAKIDDKIIVKIGPKLDLGNLIPPNYQVSTSGNDYAVWERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZM6</accession>
    <name>A0A068TZM6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoglucanase</fullName>
            <ecNumber evidence="10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00032913001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="10"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZM6"/>
    <dbReference type="FunCoup" id="A0A068TZM6">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZM6"/>
    <dbReference type="Gramene" id="CDP00818">
        <property type="protein sequence ID" value="CDP00818"/>
        <property type="gene ID" value="GSCOC_T00032913001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZM6"/>
    <dbReference type="OMA" id="AFSDHNC"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZM6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000020">
        <property type="entry name" value="Endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018221">
        <property type="entry name" value="Glyco_hydro_9_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00592">
        <property type="entry name" value="GH9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103908" description="Endoglucanase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="40"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="500" mass="55012" checksum="806C7BA883587953" modified="2014-10-01" version="1">MARKSCHIPVTSTARFSAVFLLIASSLLLHGSAVSGGQNYHDALKKSILFFEGQRSGELPPDQRVRWRKDSALHDGASAGVDLTGGYYDAGDNIKFGFPMAFTTTLLSWSIIDFGRNMGSELGNALKAVKWGTDYLLKATAKEGIIYVQVGDAISDHNCWERPEDMDTLRTVYKIDVNHPGSDVAGETAAALAAASIVFRSRDPAYSRLLLNRAMKVFQFADRHRGAYSSSLRSAVCPFYCDVNGYQDELLWGAAWLHKASRRREYREYIVRNEVILRAADTINEFGWDNKHAGINVLISKEVLMGKADDLQSFRRNADGFICSILPGISHPQVQYSPGGLIVKAGVCNMQHVTSLSFLLLAYSNYLSHANKAVPCGETLASPSLLKNLAKRQVDYILGDNPMGMSYMVGYGEHYPQRIHHRASSLPSVRVHPAHIGCKEGSRYFLSPDPNPNPLVGAVVGGPNTTDAFPDSRPFFQESEPTTYVNAPLVGLLAYFSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0W9</accession>
    <name>A0A068U0W9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B12D-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00039480001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0W9"/>
    <dbReference type="FunCoup" id="A0A068U0W9">
        <property type="interactions" value="1234"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0W9"/>
    <dbReference type="Gramene" id="CDP02170">
        <property type="protein sequence ID" value="CDP02170"/>
        <property type="gene ID" value="GSCOC_T00039480001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0W9"/>
    <dbReference type="OMA" id="NRAPQIM"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0W9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33417">
        <property type="entry name" value="G-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10262" checksum="99BB7C986E059872" modified="2014-10-01" version="1">MASSTVNRWLRPEVYPLFAAVGVAVGICGAQLIRNICINPEVRVTKENRAAGVLENHAEGEKYAEHALRKFVRNRAPQIMPSVNNFFSKPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U2W3</accession>
    <name>A0A068U2W3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00037147001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. The H form is known to activate a number of cytosolic enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family. Plant H-type subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U2W3"/>
    <dbReference type="FunCoup" id="A0A068U2W3">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U2W3"/>
    <dbReference type="Gramene" id="CDP01953">
        <property type="protein sequence ID" value="CDP01953"/>
        <property type="gene ID" value="GSCOC_T00037147001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U2W3"/>
    <dbReference type="OMA" id="DFHALWC"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U2W3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000104">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF425">
        <property type="entry name" value="THIOREDOXIN H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP01953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="121" mass="13196" checksum="E21E9AE3308079BE" modified="2014-10-01" version="1">MAEEGQVISCHTVEAWTEQLQKGNDSKKLIVVDFTASWCGPCRFIAPFLAELAKKLPTVTFIKVDVDELKSVAQDWAVEAMPTFMFLKEGKIVDKVVGANKDLLQQSIAKHLSAATATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U382</accession>
    <name>A0A068U382_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4228 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00040057001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U382"/>
    <dbReference type="Gramene" id="CDP02614">
        <property type="protein sequence ID" value="CDP02614"/>
        <property type="gene ID" value="GSCOC_T00040057001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U382"/>
    <dbReference type="OMA" id="LSAHQVM"/>
    <dbReference type="OrthoDB" id="747498at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U382"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33413">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33413:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP02614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="20702" checksum="97BA5E75CD04FF87" modified="2014-10-01" version="1">MGNCQAAEAATVVIQHPGNKVERIYWSVSAHEVMSSNPGHYVALVISSSTATRSENGTPVKQLKLLRPDDSLLMGQVYRLVSFEGMTLLLSYVLKEFAAKKSVKLGKLLKESGGLVLDTKTNLSALTPNSNSRPRLVNGTSSLIKGAHEGYGAGGSSSSGMGSNSGSSSSNRGVGRHHIGHVGQWKPALQSIAEIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4G8</accession>
    <name>A0A068U4G8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039908001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068U4G8">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP02508">
        <property type="protein sequence ID" value="CDP02508"/>
        <property type="gene ID" value="GSCOC_T00039908001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4G8"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4G8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11445">
        <property type="entry name" value="bHLH_AtPIF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000004">
        <property type="entry name" value="Basic helix-loop-helix transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031066">
        <property type="entry name" value="bHLH_ALC-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047265">
        <property type="entry name" value="PIF1-like_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45855">
        <property type="entry name" value="TRANSCRIPTION FACTOR PIF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45855:SF73">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPATULA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="407" mass="44092" checksum="02863D4D74886B75" modified="2014-10-01" version="1">MANLYDTANCSSSSPDDPDDFSLFLHQIMLRSRTSSSTSFMAQKGNEVQSYPGNQGCGLHLVSGTERISIPEAPSAGLQHWSYGGGFTSPGLGSFCQESGVNVSSSSVSVATMDNDLNDYDCESEGLEVLEEAMVKPTAPRNASKRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQLLTVRNGLSLYPMCLPGVLPSNQVPETRTEYEDNRSSDTSLASALPLKPVTPTNILFDLPDNFKKAKQASDVNQSKLSDSEDAFAPASIIHGNHRPIQFPLPGTSKGTCMGQKSPSQQANQDLSRRKSVAKHIGAEATGSTALNALPSGLEQNILEAWVLGRDQSGGRLLKNMECKNLLLSQVDGTQTGPSPLVDDSIKAERCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U662</accession>
    <name>A0A068U662_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00016524001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U662"/>
    <dbReference type="FunCoup" id="A0A068U662">
        <property type="interactions" value="1960"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U662"/>
    <dbReference type="Gramene" id="CDP04001">
        <property type="protein sequence ID" value="CDP04001"/>
        <property type="gene ID" value="GSCOC_T00016524001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U662"/>
    <dbReference type="OMA" id="NFDEHAN"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U662"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000009">
        <property type="entry name" value="Auxilin-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP04001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="109573" checksum="7E1A90ED0E4B1205" modified="2014-10-01" version="1">MDDLDVLARDFGFRPQGKSNPMRSEGGDRRSSSARSSSSAAFYDDHGSNRDGFLFNDVFGGPPRYSNNNKSSSPGNDFDYDSIFKSSSSATANSNSNNHPKTSSAPVYDKPVYDEDIFDGLPGMKSKSESSAGKFDDDVFASMASPPRRSQSNNSSNNRNDQFDDLLGKLGRNERNNNKSSSSAGFDDLLGNITMNERKPEVKSSSSRSSSSRGFDDLFGGLAGGTPANSNRPVSESNQGRKSTSSFSQSTPNTMDDPFVVLDSTSPPVSSSAGVFVDPLEEIGRLGKSGSSKAGGVFDDLDPLNGFGKSSTPFSPEKGSRGKDRSPLMSGSSASDTQTPAGQDHARSSVRQSESHSKRNAPDDSFQEPPPFDVPNVSENLQKSYHQNASSPPRVSSNVNEINSPADASPRSQEHGQTLDDIWLTVFEIPLFTPPTNAPPPSRPPPPIPRRTSKAETGFFSSNTKKKSDDFASPPSYSSFSQSPNAAWTAGKGNYASQIDELEDFATGRTQNSVDESNVHLEEEMNASSVAAASAAAMKEAMDRAEAKFRHAKEVREREYAKVARSRENVHDMQDVQERDYRENQERLEKERLQREEEEREQRRLERERERAREIERERAREIERERARHAVERATREARERAAAEARLKAERAAVEKAQGEARERAERAAVQRAQNEARERAGAEARERAEKAAAEARERANAETREREARDRAASEKAAAEARRRAERAAVERAAAEARERAAAEAREKAAAAARANQQRNDNDFESFFSMNSRPSSAPRPRANSSETMFDTNFQSTGGPQGPKPTSFGGTSSNMRKASSTTNIVDDLSSIFAAPSSGEFQEVEGETEERRRARMERHQRTKERAAKALAEKNQRDIQALKEQEERYRIAETLDIEIKRWAAGKEGNLRALLSTLQYVLWPECGWQPVSLTDLITGPNVKKVYRKATLCIHPDKVQQKGATLQQKYIAEKVFDLLKEAWNKFNSEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6U3</accession>
    <name>A0A068U6U3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00016419001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6U3"/>
    <dbReference type="STRING" id="49390.A0A068U6U3"/>
    <dbReference type="Gramene" id="CDP03914">
        <property type="protein sequence ID" value="CDP03914"/>
        <property type="gene ID" value="GSCOC_T00016419001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6U3"/>
    <dbReference type="OMA" id="WIIYMMK"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6U3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30818" checksum="B46245B8F1E4DD0D" modified="2014-10-01" version="1">MGRRRNSSAMNKLFTWVRRQSMKVKAFLAVTCLLSALVALKLLIKDHDHFFVASEAAHFLGIIVLIYKLSSQKTCSGLSLKSQELTAIFLGVRVFCSFFIEGDIHTVLDFVTLVSTLWVIYMIRFKLKSTYTAELDNMPIYYVVVPCAILAVLIYPYTSHATIYRILWAFCVYLEAISVLPQLRMIQNAKMIEAFTAHYVFALGVARFFGFAHWIILVSDTAGLNLLLVKSGYLWRLAVFLAEVVQTFILADFCYYYVKSLVGGQVLASLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U6Y8</accession>
    <name>A0A068U6Y8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ureidoglycolate hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017638001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U6Y8"/>
    <dbReference type="FunCoup" id="A0A068U6Y8">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04295">
        <property type="protein sequence ID" value="CDP04295"/>
        <property type="gene ID" value="GSCOC_T00017638001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U6Y8"/>
    <dbReference type="OMA" id="TWHAGPY"/>
    <dbReference type="OrthoDB" id="2018886at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U6Y8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35721">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35721:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21477" checksum="C296146A1B7F2310" modified="2014-10-01" version="1">MESSNGSTTSQPAPAVVKLKPIEATPETFQEFGQVIEASPDGEEFGPADAQLDLSRGIPRFYIMHLEDRALKFSNITHHANVTQCLGSIGGNVWYLGVAKPSIVDPSEIKGTTGVDVIQSHCGHYHVPPSVDDVRAFRISGPKFLKLNRGTWHAGPLFKQDAMDFYNLELSNTNVVDHTTHNFVKKNNVVFMLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7R1</accession>
    <name>A0A068U7R1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00017680001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7R1"/>
    <dbReference type="FunCoup" id="A0A068U7R1">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04327">
        <property type="protein sequence ID" value="CDP04327"/>
        <property type="gene ID" value="GSCOC_T00017680001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7R1"/>
    <dbReference type="OMA" id="DTHPRSE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7R1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000353">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g39530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000501">
        <property type="entry name" value="Putative pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000711">
        <property type="entry name" value="Tetratricopeptide repeat (TPR)-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF502">
        <property type="entry name" value="SELENIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="7">
        <location>
            <begin position="560"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP04327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="652" mass="72566" checksum="57F2D65ABF134888" modified="2014-10-01" version="1">MKRYITNPPFSDSILKTVLFSSRHFASSAATAPLDLEDDIGGFTGASFGGIIQDKDLLRKTPNGLYVLGLIDNGAMDPNATLYNQLLKRCTQLGRLKEGRLVHAHVLNSSYRNYVAVQNSIINMYAKCGSPVEARKVFDEMAERDMVSWTAVITGFSQNDRAQEALGLFVEMLRDGFVPNQFTLGSVLKAATAVGEMEGRQIHAVCLKSGHGDDVYVGSALVDMYAKCGQMEEAKVVFDGLMSKNEVCWNALIAGHARKSEAAIAVRLFSEMKKAGFEATHFTYSSVFAACASIGALEQGKWVHGHLVKSGLKLIAFVGNTLLDMYGKAGSIEDAHKVFDRLVKRDVVSWNSMLTACAQHGLGRETVECFEEMRSRGILPNEVTFLCVLTACSHSGLLEEGLYYFELMKKLKLEPDISHYVTMVDLLGRAGQLGHAEKFIKEMPIKPTAAIWKALLGACRMHKNIDLGAYAAEQVFELDPYDSGPHILLSNIYASAGRLRDAANVRKMMNDSGVKKEPACSWLEIENNVHMFVANDDSHPQRNEVRRMWEKIADKIREIGYVPDTSHVLWYVDQQEREVRLQCHSEKLALAFALLNTPHGSTIRIKKNIRVCGDCHTAFKFVSQLVGREIILRDTNRFHHFRGGSCSCGDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8K8</accession>
    <name>A0A068U8K8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00019675001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8K8"/>
    <dbReference type="Gramene" id="CDP04880">
        <property type="protein sequence ID" value="CDP04880"/>
        <property type="gene ID" value="GSCOC_T00019675001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8K8"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8K8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021929">
        <property type="entry name" value="R1A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1152">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12061">
        <property type="entry name" value="NB-LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Late blight resistance protein R1A-like N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="11">
        <location>
            <begin position="299"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="13">
        <location>
            <begin position="549"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="14">
        <location>
            <begin position="687"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP04880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114724" checksum="BD08D2642E243CB7" modified="2014-10-01" version="1">MDYILPDLLRKFNSLLLQLKEVSGGGSSAIRLADDHVLGFVDFLISKLVLLSTKSRFTDEVKVQLQTLADELRFIRSCLMDMLLQNPIQELESLNISIATLIVDAGFFVYFCPDKMEDEELTMTNYWSLGLHDSLETVQNVQQQAAGLFKKYLPLSLQSNCPSSNELEFVDFLINKLKEVMLSGEASIYPLKHQMEMVNQEMVTLRNCLSGVAELMGNSQIGFLLTRFKHAAYQAKYVLNSLMAGEGSLWLHKLGSFVITNDIKILQKEVKTTWKMNLDSGDGMQIKIEKDANKLVGRKDAVAEIVGLLTEGSSHLKILSIVGMPGLGKTTFATAVYKHPFVDTCFEVRAWGSLSQVYQKETLLSSILDQVHANPSHDISGEDVGQMLYQSLKRRRYLIVLDNIWDIETWSGLCSIFPDDENGSRILFTTRSHGVAAQANSFPYALRLLSREESCELLWLKLFNGETCPRELSRISKRIACSCKGLPLAVVLIAGALNRTKKEKDSWEKVARTFIRSQSIQEQIWDILDGSYKLLPDHLKPCFWYLGTFPRGTTISVSKLIRLWISEGFIHQPNSGQKSLIQEAESYLNDLIDRSLVLVTRKSSKGGVKECRVHDVLREFCSAILKQERYEMQEHIFPGGISVLYDTSLRKRVIFTDLSPIGRVYLTEQVPGTGSGITRQGRLHYGSVPKYKYLRVLDLANVLFRNSADTSDLVKIAELVYLRYLAIKIRTNRIPSEIGNLRNLETFHLSGAIGRVTLPEAVWKLVCLRDVIMDHCFFSFQHYSQEFFEDSTQLDNLKSLSTIYIWHGNVEKLTRMLPSVQKLGCIISNSWQECCEASNLFKLLECLRELRSLKMSFHVRAPYPFKFTFPSNLKKLTISNARLPWDEISVIGQLSNLEVLKLLSKAFEGQQWDMREGEFQKLKFLKLDSLDIVQWSASGEHLPCLEQLVVLSCQQLEEIPSCFGEISTLQLIELKCCSASAKDSVKQILDDQRDYGNHQLNVTVVGSQGGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8P2</accession>
    <name>A0A068U8P2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00016496001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8P2"/>
    <dbReference type="FunCoup" id="A0A068U8P2">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8P2"/>
    <dbReference type="Gramene" id="CDP03978">
        <property type="protein sequence ID" value="CDP03978"/>
        <property type="gene ID" value="GSCOC_T00016496001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8P2"/>
    <dbReference type="OMA" id="VMRIDQC"/>
    <dbReference type="OrthoDB" id="1880485at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8P2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328">
        <property type="entry name" value="FAR-RED IMPAIRED RESPONSIVE (FAR1) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328:SF15">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP03978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="182" mass="21304" checksum="C19CF0C28983AE2C" modified="2014-10-01" version="1">MEFDSEDAAKEFYDDYARHLGFVMRIDQCRRSEVDKRILSRRLSCNKQGYYVKMKDQYGPVRKPRSSTREGCKAMMLVKVNKSGKWVVTRFVKDHTHPLVASSRTCRTAMDHKDRKIQELTLELERQDKLCNLYHEQIITFLQSVEEETGLLSTKIEAAVKNVMEMEAEAKQQSNLQQAHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UAH2</accession>
    <name>A0A068UAH2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00018636001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UAH2"/>
    <dbReference type="STRING" id="49390.A0A068UAH2"/>
    <dbReference type="Gramene" id="CDP04623">
        <property type="protein sequence ID" value="CDP04623"/>
        <property type="gene ID" value="GSCOC_T00018636001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UAH2"/>
    <dbReference type="PhylomeDB" id="A0A068UAH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="263"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP04623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="560" mass="63596" checksum="AE4E0F4B37F8CC54" modified="2014-10-01" version="1">MDSHKVEDKELEFRPEDSIHFEKYGVSAASVEAEPCVADIESSNNKRWSSYNFPWGKGLEEFSGRLFGNFSLEPEQREVINATMSGHDVFAVMSAVEGSEVTYQLSALLCPGMTLVVVPLPSFIAHLGEHPVLGKKSMVLSDLMKLTEQQRILGELVTERCEFKLLYVTADDTITDKLLLEHLETLYDRGLLARIFIEDAESVCKRYNIPDYQGLGIFKQKFPSVPLVALASIATDRIRDEVVDILGLRNCIRFKKRRIHSRYPEQLNAGSGCFGDVFKCKVKLDDTYCAVKKIRFPASILQRVINEVKILSLAQHPNVVRYSQAWIEDYREQNTDRGYYAGSASYGPREQMMYIHMELCKGSLESKLAEEEELHTDMAWSYFRQILEALQFIHGKDIIHRDLKPDNIFIDDSGTVKIGDFGLALREKVSSTTKDVSSTTNSSPVGALLYRAPEMKERDPITDNPTNKPTNKVDMYALGLIVFQLFCPRGRSEMKLLEHPAMRRQVCEICKKYKVDETAKPLILELLKEDPSERPSAADLLRRLDGLEGEKQDAQLQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBB9</accession>
    <name>A0A068UBB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00019814001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="2"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP04943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBB9"/>
    <dbReference type="STRING" id="49390.A0A068UBB9"/>
    <dbReference type="Gramene" id="CDP04943">
        <property type="protein sequence ID" value="CDP04943"/>
        <property type="gene ID" value="GSCOC_T00019814001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBB9"/>
    <dbReference type="OMA" id="HIGQFRK"/>
    <dbReference type="OrthoDB" id="430679at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000001">
        <property type="entry name" value="GTP pyrophosphokinase RelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000030">
        <property type="entry name" value="Putative GTP diphosphokinase RSH2 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056011">
        <property type="entry name" value="DUF7589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21262:SF31">
        <property type="entry name" value="GTP PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21262">
        <property type="entry name" value="GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24500">
        <property type="entry name" value="DUF7589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="150"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP04943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="866" mass="96451" checksum="236640B5A84D08B1" modified="2014-10-01" version="1">MFLHKTTFLFPKNPTSLLFCSTTSTKLRRLPKFTCLFHHLLPNFPLASVFTSANAIVAAAAAAGSSSAHAAVSSAITHVAVTALAIASGACLSTKVDFLWPKRDDHPGSLILDGVDVTGYPIFTDAKVQKAIAFARKSHDGQLRKTGEPYLTHCIHTGKILAALIPSAGKRAVDTVVAGILHDVVDDTGETLESIEKEFDADVVRLVAGVSRLSYINQLLRRHRRLNLNQPTLSHNEANNIRVMLLGMVNDPRVVLIKLADRLHNMRTIYALPSAKAQAVAQETLAIWCSLASRLGLWAPKAELEDLCFAVLQPHIFRRMRADLASMWSPSKRNLRRLSTKSSSFGKQFGKNSISEYEQSTEIDQDEVNMKVLLQAVLPFDLLLDRKRRIDFIENLRKPSESQINPKVIRDAGIALASLVVCEEALERELFISTSYVPGMEVTLSSRLKSLYSIYSKMKRKDVGISEVYDARALRVIIGDKNGTLHGQAVQCCYNLLNIVHRLWTPIDGEFDDYIVNPKPSGYQSLHTAVQGPDNSPLEVQIRTQSMHEYAEHGLAAHWLYKETETKLPSESIIHDPEITESPYCSKEMEDQSSVDYDVFRKYSILKAGHPVLRVEAGHLLAAVIVRVDEDGKELLVAVSFGLAASEAVAARRSSYQIKRWEAYARLYKKVSDEWWCEPGHGDWCTCLEKYTLCRDGMYHKQDQFHRLLPTFIQIIELTEQEESEYWAVVSAVFEGKSLTSIVPHSSSPDRRGFNSVNSSLMDTGINNKVLLLRTMLQWEEQLRSEAGLQKIDRDSRSSGHADSAPLAEVVIICWPHGEIMRLSSGSTAADAARRVGLEGKLVSVNGQLVVPSTELKDGDVVEVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UC42</accession>
    <name>A0A068UC42_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021147001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UC42"/>
    <dbReference type="Gramene" id="CDP05847">
        <property type="protein sequence ID" value="CDP05847"/>
        <property type="gene ID" value="GSCOC_T00021147001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UC42"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP05847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="71" mass="7705" checksum="E9BDA556BEF18305" modified="2014-10-01" version="1">MNATAKALVVGGSIGAAASMVLRDQATTPGCRSSAAMPLGTIRPRLAPQFCHLSWLGKQRRRQEEKTLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCA7</accession>
    <name>A0A068UCA7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00020232001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCA7"/>
    <dbReference type="STRING" id="49390.A0A068UCA7"/>
    <dbReference type="Gramene" id="CDP05253">
        <property type="protein sequence ID" value="CDP05253"/>
        <property type="gene ID" value="GSCOC_T00020232001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCA7"/>
    <dbReference type="OMA" id="KSHIFEA"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCA7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000668">
        <property type="entry name" value="Phosphoenolpyruvate carboxylase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="42"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="517" mass="56862" checksum="F99A67390AB1728A" modified="2014-10-01" version="1">MAVAKCNGITENSPFLFKCYRVGSLTETILDTQQTSNLKDRYVLGGQLGWGQFGIIRECSDKLTGELLACKSIAKDRLVTHEDVRSIKLEIEIMTRLSGHPNVVDLKAAYEDENYVHLVMELCAGGELFNQLEKHGKFSEAEAKVIFRHLMEVVMYCHDKGVVHRDLKPENILLATKALSSPIKLADFGLATYIKQGQSLHGTVGSPFYIAPEVLIGGYDQAADVWSAGVILYILLSGIPPFWGKTKSRIFDAVRMADLQFPSNPWDYISYTAQELVMGMLCKDPSQRLSAQQVLDHTWLMDSSPLSEQPYECLKQSYGDGDLQRDPFSSSLMARNQDISFRTGLSISSDVQSPTFTCRSSLSSFLVTPSTPYYKAIGFSFQSSGGSNSVDFPIAVVSMPSFAFNSPDRVAGQGNPELDLSVDLARVDSLHQDASLRALLKLPDPSLCYGHADCKVADPTRGGSIGSKMSGIHNRRNNTISLGELEQLDLIVTESVIRWASCAHLPTAMSLRSSLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCJ0</accession>
    <name>A0A068UCJ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00021337001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCJ0"/>
    <dbReference type="FunCoup" id="A0A068UCJ0">
        <property type="interactions" value="1210"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCJ0"/>
    <dbReference type="Gramene" id="CDP05997">
        <property type="protein sequence ID" value="CDP05997"/>
        <property type="gene ID" value="GSCOC_T00021337001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCJ0"/>
    <dbReference type="OMA" id="KAECNTR"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCJ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056511">
        <property type="entry name" value="IDM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46508:SF2">
        <property type="entry name" value="INCREASED DNA METHYLATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46508">
        <property type="entry name" value="PHD FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23209">
        <property type="entry name" value="IDM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="781"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="917"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1258" mass="139699" checksum="DAD4FBD63723BC93" modified="2014-10-01" version="1">MLFGKEFEGLQDDALEGSLDEHKIFTEIFIEPDSGGRKKRCLVSGVINFEVDGTQQTDGTFCSNNANSQLTRPEDPSRLSGGDFDAKPSSGVILKVSGPSEGGDSGVSQPASLAVTCHLVESSSQGVTSYSYLLKHHQAVNAGDVISENEALNCNLSSLDGNEGKDIAVSNALASPVFQENSATKVLAATLPAIVANKLGPGRPAKPRWKDSCFLELDEAELSLPRSNKNDPRPLLRYHISCLLRAAGWVIGRRKRNNKHNLVGEHVYKSPEGRPIREFHRAWSMCRERLFSDANNVMRGTDYIQWTDMTQFWSDLSSITSVIEKQLDNWDSTAALAHLWCLLDPFANVVFIKKSLRLFKEGKPVKARRNVVIHPFGKCDSFFCSDAMQGLLSHDSYYSEKSCMDSLKAVSGTATKSRSISGNERITLRQNSLQVCGPDCSCEQTGICLFDVPLSSGNANMSLGEHETVSPGQESNRSSVTCDKERYEHNEDLPVRGAISMQRVKEEDQTFDVQMNPIGWSCVGANSNCRTYSLKAKIGDTSFARAGVRRRKTPKKSRKISEMKLTTPYKGGFNEIDGNGFKIDSGAKESYLGENSLGRRSRMSKKCGLKDDDLLISAIIKNKSCKSSHKRSISKTKHLRKRKSQKGSCKLLVRSLNRGGKHLMEGKWSLYSQRTILSWLIHSGVISRKEVIQYRNPKADVLVKDGFVTSDGILCKCCNKVLSISEFKRHAGFTLSRPCLNLFMESGKPFTLCQLEAWSAEYKVRKGAPRTVQVEEIDENDDSCGRCGDGGELICCDNCPSTFHQACLYAQELPEGNWYCPQCICQICADLVDIKDSSRCPGTLKCFQCENRYHEACLQGRDTIVEMASDTWFCSETCEQIYSGLQSRIGMMNLLSDGFCWTLLKCIHGDQKVHSAQRFVALKAECNSKLAVALTIMEECFLPMVDPRTGIDMIPQVVYNWGSQFARLNYDGFYTVVLEKNDILMSIASIRIHGVIVAEMPLIATCSKYRRQGMCRRLLNSIELMLKSLKVEKLVISAIPGLVETWTEGFGFKPLEDYEKKGLSNINLMVFPGTVWLKKSLCENESDQKPGPSAASIARVDDPTSSGGCSQGGFSQEPGQQCDQYPFEVANGVENFGSADRMKELTVKNQENGSLHHEESQHGDSFLVSEPAQHSDQGECHEEAHPGGEIRPVDSDFQLTEGQDFSCMDNHHPAKVSLDETAPLLENAQLHIVSCVESQEMYDRQNNFVEIYSLAKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCJ1</accession>
    <name>A0A068UCJ1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotase, mitochondrial</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00022979001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCJ1"/>
    <dbReference type="FunCoup" id="A0A068UCJ1">
        <property type="interactions" value="1053"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCJ1"/>
    <dbReference type="Gramene" id="CDP06255">
        <property type="protein sequence ID" value="CDP06255"/>
        <property type="gene ID" value="GSCOC_T00022979001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCJ1"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCJ1"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000006">
        <property type="entry name" value="Dihydroorotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="40"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="373" mass="41267" checksum="C163F53A14FBFB18" modified="2014-10-01" version="1">MKSSIFTCKASSFPSTTFKVLKEVKINIIKMELSITRPDDWHLHLRDGKLLEAVVPHSAHHFGRAIIMPNLKPPITTTAAAMAYRESILKALPINSGFTPLMTLYLTDSTTPAEIKLAKESGVIFAVKLYPAGATTNSQDGVTDLFGKCMPVIEEMVKHNMPLLVHGEVTSPEVDIFDREKVFIETVLSPLVQKFPQLKVVMEHVTTMDAVKFVESWRIAATVTPQHLVLNRNSLFQGGLQPHNYCLPVLKRETHRQAIVSAVTSGSKRFFLGTDSAPHDRLKKECPCGCAGIYNAPVALAVYAKVFEEAGALDKLEAFTSFNGPDFYGLPRNTSKITLRKTPWKVPESFSYASGHVVPMFAGEMLDWLPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCU1</accession>
    <name>A0A068UCU1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00023192001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <location>
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            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP06370.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="282" mass="31344" checksum="A1BD57656A1D95E4" modified="2014-10-01" version="1">MSGLYNPNFSPARAVSPQIRTNSDVDSNQYLSELLAEHQKLGPFMQVLPICSRLLNQEILRVSGMIPNQGFGDLDRLRHRSPSPMASSNLMSNVAGTGIAGWNGLPQERLSGTPGMTMDWQGAPASPSSFTVKRILRLEIPVDNYPNFNFVGRLLGPRGNSLKRVEATTGCRVYIRGKGSIKDPDKEEKLRGRPGYEHLNEPLHILIEADLPANVVDIRLRQAQEIIEELLKPVDESQDYIKRQQLRELAMLNSNFREESPGPSGSVSPFNTSGMKRPKTGR</sequence>
</entry>
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            <taxon>Coffea</taxon>
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        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
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                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
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                <person name="Aury J.M."/>
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                <person name="Bocs S."/>
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                <person name="Crouzillat D."/>
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                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
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                <person name="Perrotta G."/>
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                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="Graziosi G."/>
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                <person name="Albert V.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A068UE49</accession>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
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    </reference>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5001654809" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="110" mass="12340" checksum="C2FB868FFD55E474" modified="2014-10-01" version="1">MCIIARVVLLFHVNIGKLLTESCSSGQVLQNIQEVNDSMFIDDGEAIDLPDGLVQFWINLVELFVDIYQIFGSAAFRLSRVTVFSIITSYFLDAFLGVDQLSFNNLSIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEJ7</accession>
    <name>A0A068UEJ7_COFCA</name>
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            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEJ7"/>
    <dbReference type="FunCoup" id="A0A068UEJ7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEJ7"/>
    <dbReference type="Gramene" id="CDP06990">
        <property type="protein sequence ID" value="CDP06990"/>
        <property type="gene ID" value="GSCOC_T00024061001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEJ7"/>
    <dbReference type="OMA" id="CGYHLST"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEJ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="42"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="462" mass="49967" checksum="B9796A39013E9C03" modified="2014-10-01" version="1">MVSSRNPSSIASEREVADDLQPTGNDQKLELDAGALFVLKSKGSWMHCGYHLTTSIVAPPLLSLPFALASLGWAAGVISLVIGAAVTFYSYNLISLVLEHHAQLGHRQLRFRDMATDILGPKWGKFYVGPIQFLVCYGAVVGSTLLGGQCLKAIYVLVNPNGDMKLYEFVIMFGGLMLILAQMPSFHSLRHINLVSLVLCLAYSACATAGSIYLGNSSKGPNKNYSLSGGTETKVFGIFNSLAIIATTYGNGIIPEIQATLAPPVKGKMFKGLSVCYSVVTLTFFTVGISGYWAFGNEAESLILSNFSDNGKALLPKWFIFMTNIFTILQLSAVAVVYLQPTNEVLESTFADPKSSEFSVRNIVPRVILRSISVVISTTIAAMLPFFGDINALLGAFGFMPLDFVLPVVFFNLTFKPSKRSPIFWLNVTIAVVFGTLGVIGAVAAVRQISLDAKNYRLFANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEM3</accession>
    <name>A0A068UEM3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease P</fullName>
            <ecNumber evidence="4">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00024000001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEM3"/>
    <dbReference type="FunCoup" id="A0A068UEM3">
        <property type="interactions" value="2272"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEM3"/>
    <dbReference type="Gramene" id="CDP06946">
        <property type="protein sequence ID" value="CDP06946"/>
        <property type="gene ID" value="GSCOC_T00024000001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEM3"/>
    <dbReference type="OMA" id="ASHGCEQ"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEM3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000002">
        <property type="entry name" value="Proteinaceous RNase P 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003531">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF13">
        <property type="entry name" value="PROTEINACEOUS RNASE P 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="15">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PRORP" evidence="14">
        <location>
            <begin position="263"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="549" mass="61639" checksum="2B95EA8FBD1CCFFF" modified="2014-10-01" version="1">MNTSNTVTNMRNKKRKNLTPEIQFRLNLDHCSKNKDLSTAISLFDSVPTTGSEIHLTHHHYNSLLYICSNSVNSVHPSTKSSAIEFGFRVYHHMIANHISPSEATVTAVARLAAAKADGDAAFELARSVGNQGKLRTYAPALLCFCRNGMADKASEVEEHMGSLGLRLEEPELSALLKVNVEKGKGDKVYEYLHKLRASVREVNESTANILESWFCGEVAADVGLEIQNVDHVNQVKLRNGDGWHGLGWLGKGKWVVHRSNVASDGRCCTCGEQLTCVDIDTTETERFAQSVASLAMEREVQSNFKEFQDWIEECSDYEAIVDGANVGLYQQNFAEGGFSIPQLDAVVRELYSRSKKWPLIILHKKRIRQLLEKASNRDLLQDWIDQGLLYGTPYGSNDDWYWLYAAVKLKCLLVTNDEMRDHTFELLGNSFFLRWKERHQVKYTFVKGNLKLLMPPTYSLVIQESEKGSWHVPVAGETIDESLRTWLCITRSGSCDALASSLNDDNQLSNSNKLETLANRNNSVGHSDDKLTSITGKRKERSSSSPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UER9</accession>
    <name>A0A068UER9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024168001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UER9"/>
    <dbReference type="STRING" id="49390.A0A068UER9"/>
    <dbReference type="Gramene" id="CDP07065">
        <property type="protein sequence ID" value="CDP07065"/>
        <property type="gene ID" value="GSCOC_T00024168001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UER9"/>
    <dbReference type="OMA" id="NVTIENH"/>
    <dbReference type="PhylomeDB" id="A0A068UER9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="56" mass="5870" checksum="39A7D12839440C67" modified="2014-10-01" version="1">MADIEGSPGSSKHGVTGKERVLSLSVASPIVPTDTTAKFDLPVDSEPGKENFDCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFG2</accession>
    <name>A0A068UFG2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00023188001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFG2"/>
    <dbReference type="FunCoup" id="A0A068UFG2">
        <property type="interactions" value="1497"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFG2"/>
    <dbReference type="Gramene" id="CDP06368">
        <property type="protein sequence ID" value="CDP06368"/>
        <property type="gene ID" value="GSCOC_T00023188001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFG2"/>
    <dbReference type="OMA" id="IQPGNTC"/>
    <dbReference type="OrthoDB" id="1925347at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFG2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010605">
        <property type="entry name" value="DUF1191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512:SF14">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33512">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF1191)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06697">
        <property type="entry name" value="DUF1191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654861" description="Malectin-like domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34799" checksum="3A6FA8D78E92F864" modified="2014-10-01" version="1">MGFLTSLSMLILLTWLFWLPSPAAPSLSAARALDALLQDSAYRSFVRPRTGVVYDGQVPSNLTGIKVSGLRLRSGSLRTRGVPTYKEFQLPMGVVEEPYVERLVFVYHNLGNWSSLYYPLPSGYVFLAPVLGLLAYDASNLSATDLPELDIKATAQPISIRFSEVMTRPAVPDGSVPKCVSFDLQGLLNFTAMLAENTCATFREGHFSIVVESIGPSPAPAPPPAPPPRGKGGGGRKKNHHHKKEVWIIVGSVLGGLALLVLLGLLVVWMLKFKTRKKMQQMEKAAEVGEALHMTRVGSTKAPSATVTRTQPTLETEYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UG07</accession>
    <name>A0A068UG07_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00024246001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Activates SnRK1.1/KIN10 and SnRK1.2/KIN11 by phosphorylation of their activation-loop 'Thr-198' and 'Thr-176', respectively. Required for the regulation by SnRK1 kinases of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates with the SNF1-related protein kinase (SnRK) complex. Interacts with AL1, a geminivirus (TGMV) protein essential for viral replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP07124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UG07"/>
    <dbReference type="FunCoup" id="A0A068UG07">
        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UG07"/>
    <dbReference type="Gramene" id="CDP07124">
        <property type="protein sequence ID" value="CDP07124"/>
        <property type="gene ID" value="GSCOC_T00024246001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UG07"/>
    <dbReference type="OMA" id="KHLIERM"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UG07"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000747">
        <property type="entry name" value="Serine/threonine-protein kinase GRIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF39">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GRIK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="108"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP07124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="403" mass="45041" checksum="5546354E80231452" modified="2014-10-01" version="1">MGCCGCFGFSFAKKPKKVVRPRVFGNYTSEESLLDQEMEVEDGEFDNGDVTDTGNGDDSDLQSPVRRSEEILKYRLQNSLICREVPVKETHKLVRSEDENGNKMINEYVREYKIGSGSYGKVVLYHSSVDGIYYAIKAFHKSHLLKLRVGPFETAMSDVLREVLIMKTLNHPNIVNLVEVIDDPTTDHFYMVLEYVEGKWVFEGAGPPGGLGESTSRKYFRDIICGLMYLHAHNVVHGDIKPDNLLVTASGTVKIGDFSVSQVVEDDNDELRRSPGTPVFTAPECCLGSTYHGKAADTWAVGVTLYCMVLGRYPFLGDTLQDTYDKIVNNPLYLPDGMNPLLKDLIEGLLCKDPERRMTLEAVSEHAWVIGEGGPIPRYLCWCKRNSRSKEEVSNGSAVDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIY4</accession>
    <name>A0A068UIY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027334001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIY4"/>
    <dbReference type="STRING" id="49390.A0A068UIY4"/>
    <dbReference type="Gramene" id="CDP08446">
        <property type="protein sequence ID" value="CDP08446"/>
        <property type="gene ID" value="GSCOC_T00027334001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIY4"/>
    <dbReference type="OMA" id="NDETMTG"/>
    <dbReference type="PhylomeDB" id="A0A068UIY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF1066">
        <property type="entry name" value="METHYL JASMONATE ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658010" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="286" mass="31836" checksum="61F9CB214DD7CEAB" modified="2014-10-01" version="1">MATFYGFLVGLAIVFLAYSPSSSAVHFVLIHGSCHGAWCWYKLATLLEQAGHKVAAVDLAYSGRNQVPLEFVHTFDEYHKPLFKYLESLSPKDKVVLVGHSYGGYGVSSALERFPEKVLGGVFASAFMVGPNFTLEDTNKFLLRPDQVDDSFVIGDPIRIMLFGPHFAATMLYQNSPPEDLKLANYSMRLTQLFRGDLANRQIRVTKERYGSVPRAYVVGLEDKAITPDVQKLMIARTPPQVVREIEGADHMILFSKPQEFANNLIEIAESFESFGQGGSPHGYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJ86</accession>
    <name>A0A068UJ86_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00027037001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPR family. PCMP-E subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJ86"/>
    <dbReference type="FunCoup" id="A0A068UJ86">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP08264">
        <property type="protein sequence ID" value="CDP08264"/>
        <property type="gene ID" value="GSCOC_T00027037001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJ86"/>
    <dbReference type="OMA" id="FDCFMQM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJ86"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000196">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g14850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF452">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="5">
        <location>
            <begin position="732"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP08264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="802" mass="90031" checksum="28F2A984FAC91389" modified="2014-10-01" version="1">MATALCFSCSSKPSTVTDKDFLPGRRKAGKIIENLDVRINVRSPISTGDSPNMTRGMKWSLEQRRRLLSFVDSGCFENALHVFEEMTRPSTFIWNVLIRGLTDNGFYQEAIDLYYRMEWEGVGSDKYTFPFVIKACVGLFSLVDGQRIHSRVIKMGFDKDLYVCNSLVIMYSKLGCIEQSEKIFADMLVKDAVSWNSMISGYVASGDCLSSLTCFRDMQAARISCDRFSVISILGACSLYGCLLKGKEVHCQVIRRQLDSDPMIETSLIDMYGKCGLVQYSDRLFKRVAQRSVAVWNAIIGAYGLNDEPVRSFSCFERMLESDNLDPNAVTLINLLPSCARMRALVQGKSMHGFAIRKGMFPHVVLETALLDMYGKCGCLNLADSMFVQMKETNLISWNARIAAYVQSGNEKGALHVFQDMCSEHLHPDEITFVNILPAYAEIALPKEGQQIHANIIKLGFGSSIFICNALIYMHAKCGDIQAAQLVFNCIVYKDVISWNTIILAYGIHGFGEISVRLFSDMMAEGIKPNGSTFVSLLASCRICGMVDEGQNYFSSMKTEYNIDPGIEHYGCMVDLLGRSGNIDLAKHFIDEMPLVPTARIWGSLLSASRYHRNIELAELVADRILSLEHDNTGCYVLLSNMYAELRRWADVERIRCSMQRQGLRRTTACSLIEYNGKALQITNNDCSHAEASMIYDALDIISRKIGDDLHVCGVLKFKPPDLIRRRAHSTMYHSARLAICAGLLSTPVGTPVLVRKNVRICEDCHNAAKIISEMTDREIVVGDPKFYHRFSNGKCTCKDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJF6</accession>
    <name>A0A068UJF6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00025078001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739111">
        <property type="protein sequence ID" value="CDP07728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJF6"/>
    <dbReference type="STRING" id="49390.A0A068UJF6"/>
    <dbReference type="Gramene" id="CDP07728">
        <property type="protein sequence ID" value="CDP07728"/>
        <property type="gene ID" value="GSCOC_T00025078001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJF6"/>
    <dbReference type="OMA" id="QVFTVML"/>
    <dbReference type="OrthoDB" id="1911693at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJF6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009627">
        <property type="term" value="P:systemic acquired resistance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039265">
        <property type="entry name" value="DIR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33122:SF33">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_LIPID-TRANSFER PROTEIN_SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33122">
        <property type="entry name" value="LIPID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654854" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="108" mass="11544" checksum="20E96171DE608E24" modified="2014-10-01" version="1">MYQSRRNAVPVLLVLMVTMAGFLVQETKGSPCVSTFFSALVQLIPCRAAVAPLSPYQPNEACCVALKALGQPCLCVLINGPPISGVDRSLAMQLPEKCAANFEPCNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK84</accession>
    <name>A0A068UK84_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SS18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00027657001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK84"/>
    <dbReference type="FunCoup" id="A0A068UK84">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UK84"/>
    <dbReference type="Gramene" id="CDP08629">
        <property type="protein sequence ID" value="CDP08629"/>
        <property type="gene ID" value="GSCOC_T00027657001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK84"/>
    <dbReference type="OMA" id="GINNGMH"/>
    <dbReference type="OrthoDB" id="10265171at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UK84"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="210" mass="22341" checksum="CF7100AEF108358A" modified="2014-10-01" version="1">MQQTPMIPVMPSFPPTNITTEQIQKYLDENKKLILAILDNQNLGKLAECAQYQAQLQKNLMYLAAIADAQPQTPTMPPQMAAHPAMQQGGFYMQHPQAGAMAQQPGVFPAKMPLQYNNPHQLQDHHQQQLHQQHQQGIQGQVSVRPGGPNNGMHPMHSEAALGGGGPPASSGPSDRNKQDASEAGPSGADGQGNSATGRGGSGEGSEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKD9</accession>
    <name>A0A068UKD9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00027821001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKD9"/>
    <dbReference type="STRING" id="49390.A0A068UKD9"/>
    <dbReference type="Gramene" id="CDP08742">
        <property type="protein sequence ID" value="CDP08742"/>
        <property type="gene ID" value="GSCOC_T00027821001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKD9"/>
    <dbReference type="OrthoDB" id="2402896at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKD9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF293">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="260" mass="30039" checksum="D918D65BFB9F82E7" modified="2014-10-01" version="1">MERELGTECPMEQDQVDHDAAHGSMPEDSTNEQIEPGKDVNLYVGMGFESLGDAFKCYSNYAHNKGFSVRRNRITKSRSNKSIIGQEFKYKLQNNTWIQKVYSIRERWVPAFVHASFCAGMSTTQRSESMNKFFKDYLNSSTAMSKFVTQYDRAIKARYDKEKEKNFNTKNTKPILKTLMCFNDIMVRLQALSNKLDDLPYENEQANNLSISQVDSHSEIHDLTQGQHISKECNSIQPRNSCIKRLSSHLTDEGWFRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKG6</accession>
    <name>A0A068UKG6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026834001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKG6"/>
    <dbReference type="STRING" id="49390.A0A068UKG6"/>
    <dbReference type="Gramene" id="CDP08108">
        <property type="protein sequence ID" value="CDP08108"/>
        <property type="gene ID" value="GSCOC_T00026834001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKG6"/>
    <dbReference type="OMA" id="APNSNEW"/>
    <dbReference type="PhylomeDB" id="A0A068UKG6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF40">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="179" mass="20355" checksum="E34BE28B3865AFA5" modified="2014-10-01" version="1">MILLVLDDVWNEDTEIWDRMRKCWREIGGLRGSRILVTMVQRLESCFNMQAPSIYQLSILSKDDSWKLFEKIAFSHGGGVVKTPELIDIGRKIVAKCGRVPLAVKAIGGLMYAKKHEREWSKIENSKTWVTMEEAGSRVKSAIKLTYDHLPSLSLKQCLLGCHRRSGKYDRTLDGTGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKS9</accession>
    <name>A0A068UKS9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M-phase phosphoprotein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00028268001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKS9"/>
    <dbReference type="FunCoup" id="A0A068UKS9">
        <property type="interactions" value="1139"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKS9"/>
    <dbReference type="Gramene" id="CDP09076">
        <property type="protein sequence ID" value="CDP09076"/>
        <property type="gene ID" value="GSCOC_T00028268001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKS9"/>
    <dbReference type="OMA" id="CMVIMEG"/>
    <dbReference type="OrthoDB" id="2019850at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKS9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP09076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21122" checksum="7EE9D28C5B4C67B7" modified="2014-10-01" version="1">MAKRELSSTLKNLKFMQRVAQKEDKAKKEEEEKELVPDGNFPSCSGSQKCVIIMEGDPQPGAIRGRMSFLNFNPSIDKLNDEASNSVQPEAPSTSSGRERETNTDRGDGSPQVELENEELENSGCGSNGDLKRKTADGYEPQHPNKSQKSFQGDERSSPHNNRTPHKQPKREKLDWNVLKPPKSRSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKZ8</accession>
    <name>A0A068UKZ8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00027051001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">May be present in two forms, a 70 kDa monomer and a heterodimer of the 30 kDa and 38 kDa subunits. The ratio of the levels of the two forms within cells appears to be regulated developmentally.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKZ8"/>
    <dbReference type="STRING" id="49390.A0A068UKZ8"/>
    <dbReference type="Gramene" id="CDP08273">
        <property type="protein sequence ID" value="CDP08273"/>
        <property type="gene ID" value="GSCOC_T00027051001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKZ8"/>
    <dbReference type="OMA" id="WGWVNEG"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKZ8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000001">
        <property type="entry name" value="Beta-fructofuranosidase, insoluble isoenzyme CWINV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000002">
        <property type="entry name" value="Beta-fructofuranosidase, insoluble isoenzyme CWINV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654980" evidence="6">
        <location>
            <begin position="25"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="367"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP08273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="579" mass="65659" checksum="D5ECCD13ED6E7638" modified="2014-10-01" version="1">MEQSLLWVTVVQIFLVIAYQGTDGASDRVESILDYIPTEERGRTAYHFQPPKNWMNDPNGPMYYKGIYHLFYQYNPYAAVWGEGILSWGHSISYNLVDWIHLEDALDPTDPYDIRGCWSGSATILPGGDPAIMYTGVESTNRQVQNIAVPKNLSDPFLLEWAKLDQNPLMTPVDAIGSEFFRDPTTAWLGKDKRWRVVIGSEINGHGTALLYQSEDFVHWAKSHKPLHFSNKTDMWECPDFYPVSTNDTKGIDTSGLGRTTKHVLKASFFGHDHYIIGTYDSETDDFFPDTDFMDSNVKLRYDYGIYYASKTFFDGAKRRRILWGWVKEADDQSDDISKGWSGLQSFPRTILLDKSGKQLSQWPIEEIEGLRKDEVNLQNKEIEGGNIFEVTGITASQADIEVSFHLPNLDDAELTHPEWLDPQLLCSEKNASTGGVIGPFGLLILASENLTEYTAVFFRVFKGHDKYAVLMCSDQSRSSLREEVDISTFGAFVDVDPAEKISLRSLIDHSIIESFGGEGKTCITSRVYPTLAIGQESHLYVFNYGTESIRIANLSAWSMRRAQFFQSTKEEKPKLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULH0</accession>
    <name>A0A068ULH0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00028346001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP09137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULH0"/>
    <dbReference type="FunCoup" id="A0A068ULH0">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULH0"/>
    <dbReference type="Gramene" id="CDP09137">
        <property type="protein sequence ID" value="CDP09137"/>
        <property type="gene ID" value="GSCOC_T00028346001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULH0"/>
    <dbReference type="OMA" id="IHESTCN"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULH0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22962">
        <property type="entry name" value="DD_AtENO3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF56">
        <property type="entry name" value="CYTOSOLIC ENOLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="9">
        <location>
            <begin position="47"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="8">
        <location>
            <begin position="224"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP09137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="514" mass="56612" checksum="6F53636A8756D2C4" modified="2014-10-01" version="1">MSVQEYLDKHALSRKIEDAVNAAVRAKTPDPVLFISNHMKKSVPSMITKVKARQILDSRGIPTVEVDLYTNKGMFRASAPSGASSGMYEAIELRDGDKGTYLGNGVSRAVRNVNEKISEALIGMDPTLQSQIDQAMIDLDRTEKKESQLVFTRPLLHFSNLFLPLRESAFWEFFFQSELGANAILAVSMAACKAGAAEKEACECCFWHLVPLYKHIAVLSGNTNLSLPIPAFTLISGGKYAANFLPVKQIMILPIGARQFEEALQMGSETYHHLKAVISKKYGTDGCSVGEDGGFAPSITSIREGLDLVKEAIGRTGYSEKLKIAIDVDATEFCIGTKYDLDFKSPNKSDQNFKSGEDMINIYKELCSDYPIVSIEDPFDKEDWEHAKHFSNLGICQVVGDDLLMSNTKRIERAVEESACNALLLKVNQIGTVTEAIENVKLAKDAHWGVVISQRSGETEDAFIADLCVGLAVSQIKAGAPCRGERLAKYNQLLRIEEDLGDQAVYVGDDWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP43</accession>
    <name>A0A068UP43_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028745001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP43"/>
    <dbReference type="Gramene" id="CDP09398">
        <property type="protein sequence ID" value="CDP09398"/>
        <property type="gene ID" value="GSCOC_T00028745001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP43"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="73" mass="8469" checksum="13E1C4D998836AC8" modified="2014-10-01" version="1">MSLSLSLSQLHEGIEVVPLRSQLYFMHQKKGAEIYYVIGHLKEAAKVNSSRYYSVLLIYTRQVKENITSTIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UQ68</accession>
    <name>A0A068UQ68_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030168001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739124">
        <property type="protein sequence ID" value="CDP09723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UQ68"/>
    <dbReference type="STRING" id="49390.A0A068UQ68"/>
    <dbReference type="Gramene" id="CDP09723">
        <property type="protein sequence ID" value="CDP09723"/>
        <property type="gene ID" value="GSCOC_T00030168001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UQ68"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UQ68"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="268"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="431" mass="49078" checksum="D7B6C04C4D80DA98" modified="2014-10-01" version="1">MEEKNKAKVLDKKVPKHVREIQEKLAKLKEIEERKKREEEEKLKKEEEERLRQEELERIEEEKKRLKKERKKEKMLKKKQEGKLLTRKQKEEARRLESMRNQFLANADEGPLLSSEGNAKRPVCQTKNPKPKISSLENQDTEAMKENEDEDDQDQKSDAKSWDDFELDGTQEAKRPVYQTKNPKPKISSSENQDTEVEKENADEDDQDQEWDAKNWDDFELDGVEHDAKPEAEGVEEFGPRANSVEEEAPESNSLLPVPCSQDVSNGLRSPICCILGHVDSGKTKLLDCIRSTKVQEGEVGGITQQIGATFFPLNVPGLLVIETPGHESFANLRSRGSGLCDIAILVVDIMHGLEPLTIESLSLLKMRGTEFIVALNKMDRLLNQVITQFKEQGLNTELYYKNKEMGETFSIVPTSAITGEGIPDLLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URH0</accession>
    <name>A0A068URH0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00033020001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URH0"/>
    <dbReference type="STRING" id="49390.A0A068URH0"/>
    <dbReference type="Gramene" id="CDP11036">
        <property type="protein sequence ID" value="CDP11036"/>
        <property type="gene ID" value="GSCOC_T00033020001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URH0"/>
    <dbReference type="PhylomeDB" id="A0A068URH0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045012">
        <property type="entry name" value="NLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055081">
        <property type="entry name" value="NLP1-9_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003035">
        <property type="entry name" value="RWP-RK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32002:SF62">
        <property type="entry name" value="PROTEIN NLP6-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32002">
        <property type="entry name" value="PROTEIN NLP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22922">
        <property type="entry name" value="GAF_NLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02042">
        <property type="entry name" value="RWP-RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51519">
        <property type="entry name" value="RWP_RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RWP-RK" evidence="5">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="330"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47989" checksum="86ED5F1CDC56338F" modified="2014-10-01" version="1">MCLPKSTTGGESEDYLCKPPHQSKRGEIARIEEALDKARKIRGLRNRGIEIWTISGEILSSREGVDFIRKGQGVVGRAFLSKSACFCRDIRQLSITDYPLLLKARSLGYSSCFAVCLQSSCSNNCIYVLEFFLPTNEKDYGDCRIMLNSIMEKLKKYLRSSFKIALGQELGQKLTVEEQATSIKDRHTQYLMWFGSTIEPTSTERNLIADYEPIVEDPERDDASIEQRDNEVTNLKVQKPSYTLKSDLGITLEVLEQNSTRKLEDAAKHIGVSRFTLKRICREYGIPRWPPRKARKVNQAFAEQKIVQPSTEDTHEPHQSGATRLEDDNGMWVKAEYQGSMIKFRLPFSARKIDLEEKVAQRLNLAVGSFKIEYQDEDDDRIWITCDEDLRTFMSSLSSLGRTAIKMYIVEDSSNRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URK4</accession>
    <name>A0A068URK4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00030860001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URK4"/>
    <dbReference type="Gramene" id="CDP10208">
        <property type="protein sequence ID" value="CDP10208"/>
        <property type="gene ID" value="GSCOC_T00030860001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URK4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP10208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="68" mass="8168" checksum="302A21A168CB7798" modified="2014-10-01" version="1">MEGFEARSEPLGKYQCYYFFLFFFRQLVLLLLKTAIIMPNRRNHSQFLDCLKLEFFGSLSKTSDLFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UT74</accession>
    <name>A0A068UT74_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RPM1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00034159001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UT74"/>
    <dbReference type="Gramene" id="CDP11700">
        <property type="protein sequence ID" value="CDP11700"/>
        <property type="gene ID" value="GSCOC_T00034159001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UT74"/>
    <dbReference type="OMA" id="FRNTRVK"/>
    <dbReference type="OrthoDB" id="690341at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UT74"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="175"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="435"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="552"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="105514" checksum="0FFAAE285579B26E" modified="2014-10-01" version="1">MAVSVVGFLINQLSTLLSQESTLLGGLRADAQYIKDELGSMKAFLRQAEAKEDNDSQLQEWVKQVREVAYDTEDVLDDFAFRFAHGDADGFFGRVGKIYNSIKNLKARHRISLEIKDIKARVAEISARRHRYQLPQSTQEIGSSSSHVANADCDIRDQALLIEEAKLVGIDQPKKELISKILDDHSHLKLVSVVGMGGLGKTTLVKKVYDDAAVKKQFQSHAWITVSQNFQFKVIIKNLIQRLYEEIRQPVPPQVESMDGIRLSEFVKDFLKERRYILVLDDVWSLDAWEAIKYVLPDYNIASRVVLTTRIIDVASASCLASHDFIHIMKSLSYEDSWTLFCIRTFQSNGCPSNLEEVCRKILKKCEGLPLGIVTMGGVLALKDKDRIDEWEMIFCGFGCEMDGSSKLDRIRKILLLSYSDLPHHLKNCLLYLSIYPEDHPIDVVKLLDKWIVLGFIEKEEGMMATDIAMRYLKELINRSLIQVKDTRVDGGLKECGLHDFLREIIVSKSKEQSFTTVSTGYCTRWPDKVRHLAIHNFTDNPPQGFSSLKCLRSVETFGYEDPLTTSFLSKFLCGGPKFLKVLNLTGAELDNIPKEVFKLFHLKYLVISSTRIKVIPKSIGQLQNLEFLILAQTTIMELPVEILKLRKLRTLTVGKEGDYSNNFALWGFKSPDGIGKLTSLESLECIEVNNGKIVREIGKLVQLRQLSITKLRREDGKELVSSLSRLTNLRELYICSIKEDETLDLQHSVSPRLGFLTWLGLTGRLERVPEWVISLQSLRTLLLHNSELSEDENAIDCLGHLPNLVKLTLYRAYEGETLCFKAGGFRKLRQLGLVQLKRLKWVRVEEESMSSLQEFVIMGCKLVESLPLGLQNLTKLNVLGLADMSDDLIHEVQNLDKQSEDYQTVSHIPQVWTGHRINGRWKTKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUR6</accession>
    <name>A0A068UUR6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Extensin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00033588001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUR6"/>
    <dbReference type="STRING" id="49390.A0A068UUR6"/>
    <dbReference type="Gramene" id="CDP11368">
        <property type="protein sequence ID" value="CDP11368"/>
        <property type="gene ID" value="GSCOC_T00033588001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUR6"/>
    <dbReference type="OMA" id="DKATQYW"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006706">
        <property type="entry name" value="Extensin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36586:SF54">
        <property type="entry name" value="EXTENSIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36586">
        <property type="entry name" value="PROLINE-RICH EXTENSIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04554">
        <property type="entry name" value="Extensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655229" description="Extensin domain-containing protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Extensin" evidence="3">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="742" mass="80417" checksum="4C0AC1CCFB2F0C79" modified="2014-10-01" version="1">MGSKAKAMGSRLTPLFTTVLVVFVALGLPSETAADYDKYSPPPPPYHYYSPPPLVHSPPPPPVYKSPPPPYHYFSPPPPVYSSPPPSVYKSPPPPSPVYKSPPPPYQYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSAPSPPVHSPPPPPIYKSPPPPPPVYKSPSPPYHYSSPPPPVLLPPPPPIYKSPPPPPPVYKSPSPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPSPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPSPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPVHSPPPPPIYKSPPPPPPVYKSPPPPYHYSSPPPPTHSLPPPVYKSPPPPPPVYKSPPPPHHYSSPPPPVHSPPPPPIYKPPPPPPPIYKSPPLPPPVYKSPPPLVYKYKSPPPPSPIYKSPPPPPSPIYKSPPPPPPVYKSPPPPPPVYKSPPPPPPVYKSPPPPIYKYKSPPLPPLVYNSPPPPIYKSPPPPYHYYYNSPPPPRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUZ0</accession>
    <name>A0A068UUZ0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00035853001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUZ0"/>
    <dbReference type="STRING" id="49390.A0A068UUZ0"/>
    <dbReference type="Gramene" id="CDP12360">
        <property type="protein sequence ID" value="CDP12360"/>
        <property type="gene ID" value="GSCOC_T00035853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUZ0"/>
    <dbReference type="OMA" id="GHKEWLR"/>
    <dbReference type="PhylomeDB" id="A0A068UUZ0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="358" mass="40994" checksum="9C1C453E1A3E0FDF" modified="2014-10-01" version="1">MAVAVKKLTPQGFQGHKEWLSEVNHLGRLHHANLVKLIGFCLKGENRLLVYEYMPKHSLENHLFKRCRQPLSWETRVKIAVGAARGLYFLHNSEPPIIYRDFKASNILLDSSFQYFLQFPEFNAKLSDFGLAKHGPTGDQTHVTTRVMGTEGYAAPEYLRTDCSILSIEFHFIVPVTPEFSCCYSLFVTLTGRLNVKCDVYSFGVVLFELLTGRIAVDYRRAKEEQNLVKWVRPHLRDKRTIARIMDSRLEGQYPRKGAYVAATIALYCVNPEHKYRPPMAEVLEYLEHLQSPKFQKLPTSSDSMQQMQSSSISRSPPPALHLSPPNWSPVNRSPRGSCRPLPLKSPHRSRFSTFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUZ4</accession>
    <name>A0A068UUZ4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3 10">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00035608001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3 10"/>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUZ4"/>
    <dbReference type="FunCoup" id="A0A068UUZ4">
        <property type="interactions" value="3051"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUZ4"/>
    <dbReference type="Gramene" id="CDP12196">
        <property type="protein sequence ID" value="CDP12196"/>
        <property type="gene ID" value="GSCOC_T00035608001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUZ4"/>
    <dbReference type="OMA" id="DETCHGI"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUZ4"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="725" mass="80979" checksum="DCC2D94CCBE3D394" modified="2014-10-01" version="1">MRLIKVVTCNLNQWAMDFDCNMKNIKESISRAKEAGAVIRLGPELEITGYGCEDHFLEMDTVHHAWECLTELLRGDWTDGILCGFGMPVMKGSERYNCQILCLNRKIVMIRPKMWLANDGNYRELRWFTAWKQKDYLEDFLLPIAVSDALSQTTVPFGYGYVQFLDTAVAAEVCEELFTPMPPHAELALNGVDVFMNASGSHHQLRKLDIRLRAFIGATHSRGGVYMYSNHQGCDGGRLYYDGCSCVVVNGDVVAQGSQFSIKDVELVVAQIDLDAVASLRGSISSFQEQASCKKKISSVLVPFKLCQSFNLQMSLSSPLKIRYHSPEEEIAFGPACWLWDYLRRSGASGFLLPLSGGADSSSVAAIVGCMCQLAVREIENGDEQVKADAIRIGHYTDGQFPTNSKEFAKRIFYTVFMGSENSSEATKTRAKVLADEIGSWHLDVSIDGVVSALLSLFQTLTGKRPHYKVDGGSNIENLGLQNIQARIRMVLAFMLASLLPWVHSKPGFYLVLGSSNVDEGLRGYLTKYDCSSADINPIGSISKIDLRAFLKWAAIHLGFPSLAEVEAAPPTAELEPIRANYSQLDEVDMGMTYEELSVYGRLRKIFRCGPVSMFKNLCYKWGGNRTPLEAAEKVKHFFKYYSINRHKMTVLTPSYHAESYSPEDNRFDLRQFLYNARWPYQFRKIDELARDLDGDKVAITKSTDQEKVGMGVVAAGSGDPRAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UW44</accession>
    <name>A0A068UW44_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00036099001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDP12499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="CDP12499">
        <property type="protein sequence ID" value="CDP12499"/>
        <property type="gene ID" value="GSCOC_T00036099001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UW44"/>
    <dbReference type="OMA" id="DVCICEI"/>
    <dbReference type="OrthoDB" id="1094641at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UW44"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
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    </dbReference>
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        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039218">
        <property type="entry name" value="REM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674:SF62">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="236"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="337" mass="39057" checksum="02A48E90AB6DEC70" modified="2014-10-01" version="1">MVKGKRKDDSNRIPAFFKAFIPNTSTERLKIPIAFTKMIRGSLPDKAFLRDRYGNIWPVELARIENATFFLEGWAKFVKDNSVELGDFLVFHFDGNCVFNVKLLGHTACDKKGVGGRMFKVKEEEENEKEEDEKGENESLQNNYNTVDETDHNEEYNAEEEEEEEEEMQVQQKAKSNQRAAKPKASCKGLKKIKKSINGIHKSGTEASKCNLWKAKRIDAYGFNLFKSGKIPQPKNPYFVTKVRTKRQDELYVPVDVVKDHNLEFPPEIVLHDPKEREWRARLRRWSDGRIWYCGGWRSLCRLNLVGEEDICICEFVKREGGGLRINVTFVRPEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWC8</accession>
    <name>A0A068UWC8_COFCA</name>
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        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739153">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWC8"/>
    <dbReference type="Gramene" id="CDP12676">
        <property type="protein sequence ID" value="CDP12676"/>
        <property type="gene ID" value="GSCOC_T00036406001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWC8"/>
    <dbReference type="OMA" id="DINQEFS"/>
    <dbReference type="OrthoDB" id="623055at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWC8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043565">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051358">
        <property type="entry name" value="TF_AMS/ICE1/BHLH6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
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    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="261" mass="30065" checksum="595685936C65EE7F" modified="2014-10-01" version="1">MDDVWENMFLQTDELDSYLDESFSYYDSSSPEGAQSSAASKNIVSERNRRKKLNERLFALRAVVPNISKMDKASIIKDAIDYIQELHNQERMIQAEISELESKRSIFLDFDQEISYNSKPKRSRFEQTCDSAGSRSSPIEVLELRVSHMGEKTIVVSLTCSKRTDTMVKICEVFESLNLKIITANITAFSGRLLKTVFLEVRSSFCQVNFFSSFISLIFAVNPQFFALSIEREREKKKVNFNLFSCHVHLSHQAKNLCYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWK3</accession>
    <name>A0A068UWK3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037431001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWK3"/>
    <dbReference type="FunCoup" id="A0A068UWK3">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWK3"/>
    <dbReference type="Gramene" id="CDP12781">
        <property type="protein sequence ID" value="CDP12781"/>
        <property type="gene ID" value="GSCOC_T00037431001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWK3"/>
    <dbReference type="OMA" id="SVSLWCP"/>
    <dbReference type="OrthoDB" id="646981at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWK3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="404"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="491" mass="55552" checksum="C1BF4C4E5F339508" modified="2014-10-01" version="1">MEFEKMYFDVEPSYIIDHHCSLETALTFPNNHLIPPYSFQDYVSNDIVSTENFLEMETDIKDFDFMAKNCALDHENVVHKRLLPCQEIQETMDILAAEQSHLKDIQDELMEESSLTDLLLMGAEAIEAGNVRFASLVALRLKDILSDQENGDNPLDRLALYFTQGLLDKSLTAPELPEDPVSPQTNAISAFQMLQELSPYVKFAHFTANQAILEATEGHQEIHVIDFDVMEGIQWPSLMVDLAAREDASLRITAIAGDKRSSCNIQQTGFRLQDFANSINLSFSFDQVLVTKEEDFEEIKVGHTLIANCMINQLHMPYRESSLVKTFFNGLRKLSPKILVLVQEELFSFSKAPSTSFAEFFCEALDHYTALYDSLRSGFCAGYKLALKIIEKEFLRMRILDSVKHFPCGIMGNESNMLPDYPSMNGFRPIPTSSCNVTQAKHLISLFNGGYWVQNEQCKLTLCWKSRPLTTASIWVPTASSNTSLARSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYI1</accession>
    <name>A0A068UYI1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00038185001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYI1"/>
    <dbReference type="FunCoup" id="A0A068UYI1">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UYI1"/>
    <dbReference type="Gramene" id="CDP13294">
        <property type="protein sequence ID" value="CDP13294"/>
        <property type="gene ID" value="GSCOC_T00038185001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYI1"/>
    <dbReference type="OMA" id="MMRGCGC"/>
    <dbReference type="OrthoDB" id="10044893at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009788">
        <property type="term" value="P:negative regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF20">
        <property type="entry name" value="F-BOX PROTEIN SKIP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="461" mass="51457" checksum="D68DF9B7303CD3FB" modified="2014-10-01" version="1">MALNYSHRPIFPAHIAEDNLVSPLRIVNGYLVEGFIDRARDGIDGCNSRESGSEDIVDLLPSDPFGMDISTTFTAITGWLEDLEVDYRGCGTKNNNIGVGNEDYGLFAGFSILWKSAMRLQSIPGNAQTNWNMKTAGKIDQYSEARDVGHASAQSSCEPTNLEGNIKNVGAITRSLEIEEESEDSVWSSVYDDGSPHEALYYALGYLGVKDLLLAERVCRSLCHAVRNDPLLWRSIHIEQPLNEKITDDVLFELTSRAQGNLECLTLVECPRITDGGLRRVLESNPRLNKLCVPGCTRLNIEGIVNILKSFNLHNGCLGIKYLRIGGLYGVTHEHVEDLKILLGVDKKVQENIYKPHFYLRGKFYVLCDDDRALDVEVCPICQKLRLIYDCPSEGCQVKDQNAQLCRACALCIPRCAQCGRCINDGEYEETFCLDNVCSDCFQNLSKDHDKHDRKLGSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZP8</accession>
    <name>A0A068UZP8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00038824001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vesicle trafficking protein that functions in the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">trans-Golgi network membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Prevacuolar compartment membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZP8"/>
    <dbReference type="FunCoup" id="A0A068UZP8">
        <property type="interactions" value="3049"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZP8"/>
    <dbReference type="Gramene" id="CDP13772">
        <property type="protein sequence ID" value="CDP13772"/>
        <property type="gene ID" value="GSCOC_T00038824001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZP8"/>
    <dbReference type="OMA" id="DSTCYIA"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZP8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000030">
        <property type="entry name" value="syntaxin-51 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF285">
        <property type="entry name" value="SYNTAXIN-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="224" mass="25009" checksum="85B202BDEA86F9DA" modified="2014-10-01" version="1">MASSGDPWVKEYNEAVKLADDITNMISERNSLPATGPEAQRHASAIRRKITILSTRLESLQSLLSRLPGKQLTEKEMNRRKDMLANLRSKVNQMASTLNMSNFANRDSLLGPEIKPVDAMTRAKGLDNYGVVEQDEGLEKLEETVISTKHIALAVNEELDLHTRLIDNLDEHVDVTDSRLQRVQKRLAILNKKTKGGCSCMCLLLSVIGIVVLVAVIYLLVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1E5</accession>
    <name>A0A068V1E5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L30 ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00040766001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739166">
        <property type="protein sequence ID" value="CDP14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1E5"/>
    <dbReference type="FunCoup" id="A0A068V1E5">
        <property type="interactions" value="3021"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1E5"/>
    <dbReference type="Gramene" id="CDP14387">
        <property type="protein sequence ID" value="CDP14387"/>
        <property type="gene ID" value="GSCOC_T00040766001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1E5"/>
    <dbReference type="OMA" id="DYITWGE"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1E5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28364" checksum="0D8FBB72185DA965" modified="2014-10-01" version="1">MAEEQAKVVPESVLKKQKRNEEWALAKKQELDAAKKKNLANRKLIYNRAKQYAKEYEEQQKELIKLKREARLKGGFYVNPEAKLLFIVRIRGINAMHPRTKKILQLLRLRQIFNGVFLKVNKATLNMLHRVEPYVAYGYPNLKTVKELIYKRGYGKVNKQRIALTDNSIIEQTLGKHGIICIEDLVHEIMTVGPHFKEANNFLWPFKLKAPLGGLKKKRNHYVEGGDAGNREDYINELIRRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1G1</accession>
    <name>A0A068V1G1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protease Do-like 5, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00040803001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739167">
        <property type="protein sequence ID" value="CDP14407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1G1"/>
    <dbReference type="FunCoup" id="A0A068V1G1">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1G1"/>
    <dbReference type="Gramene" id="CDP14407">
        <property type="protein sequence ID" value="CDP14407"/>
        <property type="gene ID" value="GSCOC_T00040803001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1G1"/>
    <dbReference type="OMA" id="TPYSNRY"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1G1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051201">
        <property type="entry name" value="Chloro_Bact_Ser_Proteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343">
        <property type="entry name" value="PEPTIDASE S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343:SF6">
        <property type="entry name" value="PROTEASE DO-LIKE 5, CHLOROPLASTIC ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655435" description="Protease Do-like 5, chloroplastic" evidence="4">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP14407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33336" checksum="6BFDCEE3D011C45B" modified="2014-10-01" version="1">MVVLAALHCMASSVVAHYTKSAPYPSQSGSMDTELSFTKRKALLCSSSLMLSGLSWFKSNSALALQVDELQQQEERIVELFQEISPSVVFIKDLELTKVPKNSAQIAALDAENAKVEGTGSGFIWDQFGHIVTNYHVVAKLATDRSGLQFCKISLVDARGNNFSREGKIVGYDPDYDLAVLKINVEGDELKPATLGTSQGLHVGQSCLSIGNPYGYANTLTTGVISGLGREIPSPNGRAIKGAIQTDAAISAGNSGGPLIDYYGHVIGVNTATFTRKGTGMSSGVNFAIPIDTVLRTVPYLIVYGTPYADRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3X4</accession>
    <name>A0A068V3X4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00042900001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739181">
        <property type="protein sequence ID" value="CDP15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3X4"/>
    <dbReference type="FunCoup" id="A0A068V3X4">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V3X4"/>
    <dbReference type="Gramene" id="CDP15252">
        <property type="protein sequence ID" value="CDP15252"/>
        <property type="gene ID" value="GSCOC_T00042900001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3X4"/>
    <dbReference type="OMA" id="CDSDLPN"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3X4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11076">
        <property type="entry name" value="CYP78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000016">
        <property type="entry name" value="Cytochrome P450 78A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051996">
        <property type="entry name" value="Cytochrome_P450_78A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47946">
        <property type="entry name" value="CYTOCHROME P450 78A7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47946:SF14">
        <property type="entry name" value="CYTOCHROME P450 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60040" checksum="5DA6C8144BADBBCD" modified="2014-10-01" version="1">MSTDPCCFSSSIPLTGYPSTVLNFELVLCFLLFLAVFAFWLTPGGLAWALAVSNKKLSSKKDATSAAIPGPSGLPLLGLVLAFTGSLTHRVLGKISRSLKAETLMAFSVGFTRFIISSHPETAKEILNSSAFADRPVKESAYELLFHRAMGFAPYGEYWRNLRRISATHLFSPKRIACSGIFRRDIGVKMVEEIKGLMERNGEVEVKKVMHFGSLNNVMMSVFGRCYDFDGDDGSVLEGLVSEGYELLGIFNWTDHFPILGWLDMQGVRKRCRELVARVNVFVGNIIDEHRLKRMAENRGGVGRKPAIDDDEGSGDFVDVLLDLEKENNSLTNSDMIAVLWEMIFRGTDTVAILLEWIIARMVLHPDIQSKAQAEIDCVVGTSRMVTDADLPNLPYLHAIVKETLRMHPPGPLLSWARLAVHDTHVGRHFIPAGTTAMVNMWAITHDEMVWPEPEHFMPERFLNEDVAIMGSDLRLAPFGSGRRACPGKALGLATVQMWLAQVLQNFEWIASGDVDLSECLKLSMEMKNPLVCKAVARFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4E8</accession>
    <name>A0A068V4E8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015413001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4E8"/>
    <dbReference type="Gramene" id="CDP15541">
        <property type="protein sequence ID" value="CDP15541"/>
        <property type="gene ID" value="GSCOC_T00015413001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4E8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34741">
        <property type="entry name" value="IMAP FAMILY MEMBER 1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34741:SF2">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13285" checksum="4A3ED5E02FEEC326" modified="2014-10-01" version="1">MADTMNVQWVFLVIGVSFVAINTSLQAAQIPGSLPAIFHWFYLALELAFLAVLVSSYLQRPYPNASRLIQHLGVLFAAVAFIMAISMPLLHPPLKPLSNKLFLIAFLIIILASRCISFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5A6</accession>
    <name>A0A068V5A6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00015725001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739188">
        <property type="protein sequence ID" value="CDP15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5A6"/>
    <dbReference type="FunCoup" id="A0A068V5A6">
        <property type="interactions" value="2895"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5A6"/>
    <dbReference type="Gramene" id="CDP15717">
        <property type="protein sequence ID" value="CDP15717"/>
        <property type="gene ID" value="GSCOC_T00015725001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5A6"/>
    <dbReference type="OMA" id="HRPFDEI"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5A6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="396" mass="44464" checksum="1C017AEB5E0715FE" modified="2014-10-01" version="1">MGSSNHQWLNVLLLQSKVLRPTQRLVGFAILHQAYYSQQPSSNPFSFVLVDAASNEEAENFERGFVLQLLGSTSSTNTAEVLKLSAADYIRSFDPSSHAFPSSEQLQQQYCSKVGPEPFGSLFRNHVINILPDPDVPHGCDPNSTEFDWQPGVTPKIGSGDRDESISGLLQNLSLEGLGPQWIRPRPPRLPVLEGELVWLNPDNTHELMWDHGMCADTSRGAAVRDLIAKALKGPLAPAQQEQVLLELANDPKLVYHCGLTPRKLPELVENNPVIAVEVLIKLANSPEIEEYFTVLVNMDMSLHSMEVVNRLTTAVELPTEFIHLYITNCISSCENTKDRYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRMREAATLFRLLKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6H7</accession>
    <name>A0A068V6H7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00017311001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="HG739203">
        <property type="protein sequence ID" value="CDP16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V6H7"/>
    <dbReference type="FunCoup" id="A0A068V6H7">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V6H7"/>
    <dbReference type="Gramene" id="CDP16206">
        <property type="protein sequence ID" value="CDP16206"/>
        <property type="gene ID" value="GSCOC_T00017311001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V6H7"/>
    <dbReference type="OMA" id="DPWFKRR"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V6H7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000230">
        <property type="entry name" value="tRNA (Guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF21">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="329" mass="37198" checksum="8560073A4DE7DC29" modified="2014-10-01" version="1">MAMAVASPVTATATACRKILLTHFAFRKLRQPPTTRRLVSSVQPRHHCYRAAATASSAGAVEQEVQLIRSPELVAQEYADLSLADKFSEELGHVRIRQHVNPLRSTFMVPAEVPDWNEVYKDPTLPLMVDIGCGSGRFLMWLAKRNPSSKNYLGLEIRRKLAERANYWANDLALNNVHFVFANVTVSFKQLVSAYPGPLMLVSILCPDPHFKKKYHKRRVVQKPLVESIVDILAPGGQVFIQSDVLELAIDMRDQFDAKSNKLIHVDKIDPNLSCDTEGWLISNPMGIRTEREIHAEFEGARIYRRMYKKCVQLSMPSAADQESQLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V6K0</accession>
    <name>A0A068V6K0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
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                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
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                <person name="Lan T."/>
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                <person name="Li L.T."/>
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                <person name="Perrotta G."/>
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                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
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                <person name="Albert V.A."/>
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            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">cv. DH200-94</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">cv. DH200-94</strain>
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                <person name="Pietrella M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
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                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
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                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739250">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="49390.A0A068VA91"/>
    <dbReference type="Gramene" id="CDP17507">
        <property type="protein sequence ID" value="CDP17507"/>
        <property type="gene ID" value="GSCOC_T00011438001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA91"/>
    <dbReference type="OMA" id="VRQLIMH"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22464">
        <property type="entry name" value="KH-I_AtC3H36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF184">
        <property type="entry name" value="CCCH-TYPE ZN-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP17507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="302" mass="31398" checksum="CF12122EC6404C69" modified="2014-10-01" version="1">MEFGGARKRGRPDGGAATNGNGGIKKSKQETESFSSGIGSKSKPCTKFFSTSGCQFGEGCHFLHYVPGGIKAVTQILGSNPALPAASRNPVVPPSFPDGSSPPAVKTRLCNKYNTAEGCKFGDKCHFAHGAWELGKPTAPVHEDPRATGPLPGRFGGRMESTPPDFGAAGSFGASATAKISVDASLAGAIIGKGGVNSKHICRTTGAKLAIRDHDSDPNSKNIELEGTFDQIKLATQMVRELIANVSSAARPPLKNHGGPKGSAPASNFKTKLCENFAKGSCTFGDRCHFAHGEEELRSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VAV2</accession>
    <name>A0A068VAV2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00019313001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739220">
        <property type="protein sequence ID" value="CDP16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VAV2"/>
    <dbReference type="STRING" id="49390.A0A068VAV2"/>
    <dbReference type="Gramene" id="CDP16798">
        <property type="protein sequence ID" value="CDP16798"/>
        <property type="gene ID" value="GSCOC_T00019313001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VAV2"/>
    <dbReference type="OMA" id="CAYYVTG"/>
    <dbReference type="PhylomeDB" id="A0A068VAV2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="282" mass="31794" checksum="21548D20BE830234" modified="2014-10-01" version="1">MEMQQVLRMRGGDDHASCAKNSAFQILISMKVSSELKRSIQEFCRANLPAAAGCISITDLGCASGSNTLWAIQDVIENFDRKCHDSNIYLPRPSIQYYEGSPGSCFIAAMPGSFHGRLLPDNSMHFIHSCYSLHWLSQVPRELVTQKGMPLSKGNIYIGKTSPRSVSKWVIWAGMTMNDMVIEGLIEEKAVDNFNLPHYQPSVEELRTIIEKNHAFKIGYLDIIEVQWVDAEAADYGKNYTFDKNTNGIIDDFFRMFDPKISQYHGKIKDSSNNHAVSLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBT6</accession>
    <name>A0A068VBT6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00012019001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739305">
        <property type="protein sequence ID" value="CDP18290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBT6"/>
    <dbReference type="FunCoup" id="A0A068VBT6">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VBT6"/>
    <dbReference type="Gramene" id="CDP18290">
        <property type="protein sequence ID" value="CDP18290"/>
        <property type="gene ID" value="GSCOC_T00012019001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBT6"/>
    <dbReference type="OMA" id="REKWAVE"/>
    <dbReference type="OrthoDB" id="1927263at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBT6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33492:SF4">
        <property type="entry name" value="OS02G0174300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33492">
        <property type="entry name" value="OSJNBA0043A12.37 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP18290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="289" mass="33278" checksum="F49402C1C9BF1F12" modified="2014-10-01" version="1">MERGSRCTRSQAAPDWSAWECLTLVNEINAVEGEWRQTLASFQKWQLIVENCSALGMNRSMNQCKKKWDALRNEQKKVKQWEAAYWSFATAEKKELGLPEEFDKELFNAVEKHMNQRGDDPAALDTELDSDPEAQPIASKMFLQTGPKKQRKKRMPPRKDKFEERFHPWKHILKGVVKPEPSALDEIPDQPPKSTAQMVKPEQISKEEKQKIMTAKLLENAQLINAVLQGNLAEDVDYKLADLKNNEAMQTDSTRRQGDKIIDCLGNIVSTLNQFCHLVQECNLRPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD02</accession>
    <name>A0A068VD02_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00012827001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="HG739327">
        <property type="protein sequence ID" value="CDP18472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VD02"/>
    <dbReference type="STRING" id="49390.A0A068VD02"/>
    <dbReference type="Gramene" id="CDP18472">
        <property type="protein sequence ID" value="CDP18472"/>
        <property type="gene ID" value="GSCOC_T00012827001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD02"/>
    <dbReference type="OMA" id="YPLYAFY"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VD02"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF51">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="9">
        <location>
            <begin position="85"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP18472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="377" mass="43151" checksum="D768CBBF0D9AC6F1" modified="2014-10-01" version="1">MAIAAVVILPLGLLFLLSGLIINFIQALIFILVRPLSKNLFRRINKEVTELLWLEIVWLFDWWANIKVELYTDPETFEFLGKEHALLICNHRSDIDWLVGWVLAQRFGCLGSTLALIKKAALYLPVLGWSMWFNNYIFLERSWTKDEYTLKSGLQGLNDFPRPFWLALFVEGTRFTQAKLLAAQEYAASAGLPVPQNVLIPRTKGFVYVVSELSSFVPAIYDITVTIPKNEPQPTMLRILRGCSSVVHVHIERHLMQELPETSSGISQWCKDIFVAKDALLERHVAMNTFGNKDNYHIGRPIRSLLVVISWTCFLIFGAVNFFEWCPFSWGEIAFCTVFLALVVVLMQILIVFSQSEQSTPVKESPRNSLEEKLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE35</accession>
    <name>A0A068VE35_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00001045001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP18996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE35"/>
    <dbReference type="FunCoup" id="A0A068VE35">
        <property type="interactions" value="1914"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VE35"/>
    <dbReference type="Gramene" id="CDP18996">
        <property type="protein sequence ID" value="CDP18996"/>
        <property type="gene ID" value="GSCOC_T00001045001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE35"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="1256648at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VE35"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
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    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655837" description="40S ribosomal protein S27" evidence="6">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP18996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="111" mass="12506" checksum="EBA3F4466E8415FD" modified="2014-10-01" version="1">MCYILLLERLILCSCFLLVFGFNHLKVLPNDVDLLNPPADLEKRKHKLKRLVPSPNSFFMDVKCQGCFNITTVFSHSQTVVVCGNCQTVLCQPTGGRARLTEGCSFRRKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VE51</accession>
    <name>A0A068VE51_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_346</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00006753001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP19100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VE51"/>
    <dbReference type="Gramene" id="CDP19100">
        <property type="protein sequence ID" value="CDP19100"/>
        <property type="gene ID" value="GSCOC_T00006753001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VE51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="93" mass="10559" checksum="22329B3FD1863BF8" modified="2014-10-01" version="1">MPPISIIGIYWLYAPSSGVYVQLTHSNSNSTVYKSFFSGQIKSKSKKSNSRSEFIQFLLNQNGSYEANSWQVHRRKGSKETACHKVYMLSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEA6</accession>
    <name>A0A068VEA6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00008631001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">DH200</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DH200</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Binds unmodified and methylated histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739282">
        <property type="protein sequence ID" value="CDP18028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEA6"/>
    <dbReference type="FunCoup" id="A0A068VEA6">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VEA6"/>
    <dbReference type="Gramene" id="CDP18028">
        <property type="protein sequence ID" value="CDP18028"/>
        <property type="gene ID" value="GSCOC_T00008631001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEA6"/>
    <dbReference type="OMA" id="RVCFKAG"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEA6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010385">
        <property type="term" value="F:double-stranded methylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009744">
        <property type="term" value="P:response to sucrose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000082">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000020">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000691">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="19">
        <location>
            <begin position="228"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDP18028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="825" mass="93148" checksum="A7176AD3DCC99065" modified="2014-10-01" version="1">MAETPKKRSKQTPKHQQHDLSSSNAITIPATPVALDPTPVRRSSRLYTTPTAATAPPPPPPRFTRRKSLNFTTTTPTPIPKTPKKPAPQSQEDAAKQISPISPDRYETRRKRKLDEEKNAGLAKNKDLKGGKKRVYYRKVVYDGGEFSIGDDVYVKRRENAESDNEDPEVEECVMCFKAGRAVMIECDECLGGFHLKCLKPPLKEVPEGDWICRFCEATKLGKNVELPVPPAGKKRARTAKEKLLSSDLWAAHIESMWKEVDGTYWFRSRWYIIPEETDAGRQPHNLRRELYRTNEFADVEMESIIRHCYVMNPKDFSKAADEGDDVFLCEYEYDVCWHSFKRIAEISNNEEDAEEDESDKDWNSCEITDSDSEDDTDYKKEKINGSQRGPSFGHSLAANLRKGQFFGLQKIGAKKIPEHTRCHKQTEIGKAKAMLLLACLPKSPPCRNKEMEEITAFIKGAVSDGQCLGKCLYIHGVPGTGKTMTVLAVMRTLKIEVDSGNIKPYCFVEINGLKLASPENIYRVIYEALTGHRVSWKKALHLLNERFSNGTNWEEENNKPCILLIDELDLLVTRNQSVLYNILDWPTKPHSKLIVIGIANTMDLPEKLLPRISSRMGIQRLCFGPYNYQQLQEIISSRLKGIDAFEKPAIEFASRKVAAVSGDARRALEICRRAAELADYRLRKSQSLNDSAGTRRSLVGVADVEAAIKEMFQAPHIQVMKSCSKLSKIFLAAMVHELYKTGMGETSFEKLAMTVSCLCTSNGEAFPGFDTLFRVGCKLGECRIILCEAGVRHKLQKLQLNFPSDDVTFALKDSKDLPWLAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEC1</accession>
    <name>A0A068VEC1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00003254001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739392">
        <property type="protein sequence ID" value="CDP18932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEC1"/>
    <dbReference type="STRING" id="49390.A0A068VEC1"/>
    <dbReference type="Gramene" id="CDP18932">
        <property type="protein sequence ID" value="CDP18932"/>
        <property type="gene ID" value="GSCOC_T00003254001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEC1"/>
    <dbReference type="OMA" id="YECWIIT"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEC1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000003">
        <property type="entry name" value="Cyclic nucleotide-gated ion channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000024">
        <property type="entry name" value="Cyclic nucleotide-gated ion channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651:SF114">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="281"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP18932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="540" mass="62190" checksum="94D2C2C561FC1EA6" modified="2014-10-01" version="1">MPLNQQPAAARANHAISLVIMLQYIPRLFVIFPLNWKIIKNTGVVAKTAWSGAAYNLILFMLASHVLGASWYLMSFERHLTCWRMICEKEKTRHHCDTLFLDCLKSGDEKDAWKKSTKAFTTCTPDKFEFGLFAEAYEDQITSVNIAERYFYCLWWGLRNLSSYGQNLAASTQVVETLFSCLICLVGLSFFGFLIGNMQTYLESTTARLEEWRVKRRDTEEWMRHRQLPPDLQDRVRRFVQYKWLATRGVDEEEILQALPLDIRREIQRHLCLNLVRRVPFFSQMDDQLLDAICERLVSSLNTKDTYIVREGDPVAEMLFIIRGELESSTTNGGRSGFFNSITLKPGDFCGEELLTWALMPTSNLNLPSSTRTVKSLTEVEAFALRAEDLKFVANQFKRLHSKRLQHAFRYYSHQWRTWGACFIQAAWRRLKRKRLAEELARQEYSCNLQFFDEDSQYGDAFAAAVYGSTTTGTAAMDGIPQHLGATVLASRFAANTKRGPKVTRVEAASSSLPMPKLFKPDEPDFHADKEYTKDTEEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VED8</accession>
    <name>A0A068VED8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00012367001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NIPA (TC 2.A.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739400">
        <property type="protein sequence ID" value="CDP18952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VED8"/>
    <dbReference type="Gramene" id="CDP18952">
        <property type="protein sequence ID" value="CDP18952"/>
        <property type="gene ID" value="GSCOC_T00012367001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VED8"/>
    <dbReference type="OMA" id="QEWLWWA"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VED8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF25">
        <property type="entry name" value="MAGNESIUM TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP18952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="345" mass="37299" checksum="D96AA3246CADD24C" modified="2014-10-01" version="1">MYTANLIGFGLAVASSAFIGSSFIIKKKGLQRAGASGSRAGSGGHGYLREPLWWIGMIAMIFGEFANFVAYIYAPAVLVTPLGALSIIVSAVLAHFLLKEKLRKMGILGCILCVVGSTVIVLHAPGEHDISSVDEIWELATQPAFVLYAASAIAVVLALVLYCEPRYGQTNLMVYIGVCSIFGSLTVMSIKAIGIAIKLTLEGFSQAAHYQTWVFVMIAVTCIITQLNYLNKALDTFNTAVVSPIYYAMFTSLTIFASAIMFKDWAGQSASSIVSVLCGFVTVLSGTVILHSTRDPEAPPVSDAYSSLSPQISWLVHANGEIWKHKDNDEMHPEFVAIIRQDHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VF14</accession>
    <name>A0A068VF14_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate dehydrogenase (acetyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00001661001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of 2 alpha and 2 beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4"/>
    <dbReference type="EMBL" id="HG739445">
        <property type="protein sequence ID" value="CDP19154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VF14"/>
    <dbReference type="FunCoup" id="A0A068VF14">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VF14"/>
    <dbReference type="Gramene" id="CDP19154">
        <property type="protein sequence ID" value="CDP19154"/>
        <property type="gene ID" value="GSCOC_T00001661001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VF14"/>
    <dbReference type="OMA" id="VRLCTKD"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VF14"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="84"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP19154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="44046" checksum="9ABE5D75842A7520" modified="2014-10-01" version="1">MAAIVQGIGSTAAPSASSNKFLLSSLGSSLLEKKRNFFVVRSDGKCYTGLNQQQRRAQNVVTNAVATKEEKASAAVGSKPGHELLLFEALREGLEEEMDRDPCVCVMGEDVGHYGGSYKVTKGLAEKYGDLRVLDTPIAENSFTGMGIGAAMTGLRPIVEGMNMGFLLLAFNQISNNCGMLHYTSGGQFKIPIVIRGPGGVGRQLGAEHSQRLESYFQSIPGIQMVACSTAYNAKGLMKAAIRSDNPVILFEHVLLYNLKERIPDEEYVLNLEEAEMVRPGEHVTILTYSRMRYHVMQAAKTLVNKGYDPEVIDIRSLKPFDLYTIGNSVKKTHRVLIVEECMRTGGIGASLTAAINENFHDHLDAPIVCLSSQDVPTPYAGTLEEWTLVQPAQIVAAVEQLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VG83</accession>
    <name>A0A068VG83_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00007799001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739653">
        <property type="protein sequence ID" value="CDP19617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VG83"/>
    <dbReference type="FunCoup" id="A0A068VG83">
        <property type="interactions" value="3301"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VG83"/>
    <dbReference type="Gramene" id="CDP19617">
        <property type="protein sequence ID" value="CDP19617"/>
        <property type="gene ID" value="GSCOC_T00007799001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VG83"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VG83"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000177">
        <property type="entry name" value="Importin beta-like SAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="886"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP19617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118580" checksum="DF949797FEB5FAFC" modified="2014-10-01" version="1">MDLQNLAIILRGALSPNPDERKAAEESLNQFQYTPQHLVRLLQIIVDGNCDMAVRQVASIHFKNFIARNWAPHDPGEQSKILPSDKDVVRQNILNFIAQVPQLLRVQLGECLKTIIHADYPEQWPALLHWVKLNLQDQQVFGALFVLRILARKYEFKSDEERTPVYHIVDETFPPLLNIFNRLVQITNPSIEVADLIKLICKIFWSCIYLEIPKQLFDPNVFNAWMVLFLNVLERPVPLEGQPVDPEVRKSWGWWKVKKWTVHILNRLYTRFGDLKLQNPDNKVFAQMFQKNYAGKILECHLNLLNVIRVGGYLPDRVINLILQYLSNSISRSNMYNLLQPRLDVVLFEIIFPLMCFSDADQKLWDEDPHEYVRKGYDIIEDLYSPRTAAMDFVSELVRKRGKENLQKFILFIVEIFNRYNEAVPEYKPFRQKDGALLAIGALCDKLKQTEPYKSELERMLVQHVFPEFSSPAGHLRAKAAWVAGQYAHVNFSDPNNFRNALRSVVAGMRDPELPVRVDSVFALRSFVEACKDLDEIRPILPQLLDEFFKLMNEVENEDLVFTLETIVDKFGEEMAPYALGLCQNLAAAFWKCLNTAEADDEADDPGALAAVGCLRAISTILESVSSLPHLFVQIEPTLLPIMRRMLTTDGQEVFEEVLEIVSYMTFFSPTISMDMWSLWPLMMEALADWAIDFFPNILVPLDNYVSRSTVHFLTCKEPDYQQSLWHMISSIMADKNLEDGDIEPAPKLIQVVFQNCRGQVDHWVEPYIRIAVERLRRTEKPYLKCLLIEVIADALYYNASLTLSILHKLGVASDIFALWFQMLQQTKKNGVRANFKREHDKKVCCLGMTSLLSLPNDQFPAEALERVFKATLELLVAYKEQLAETEKEAAEDNDDMDGLPTDDEDDDGDVSDKEMGIDDEDGDEADSIKLQKLAAQAKAFRSTEDDEDDSDDDFSDDEELQSPIDDVDPFVFFVDTIKALQASDPLRFQNLTQTLDFHFQALANGVAQHAEQRRVEIEKEKMEKASSAAVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH36</accession>
    <name>A0A068VH36_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00001041001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739407">
        <property type="protein sequence ID" value="CDP18993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH36"/>
    <dbReference type="FunCoup" id="A0A068VH36">
        <property type="interactions" value="1295"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18993">
        <property type="protein sequence ID" value="CDP18993"/>
        <property type="gene ID" value="GSCOC_T00001041001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH36"/>
    <dbReference type="OMA" id="HGFEFNF"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH36"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17351">
        <property type="entry name" value="MFS_NPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69622" checksum="4F686E2CCEFC2CC9" modified="2014-10-01" version="1">MAGATEIASPEVLPDDISSSDSLRRKKLGIYFIESDDRRTAFSGGYVGGGSTPVNIHGKPISNLSSTGGWIAAFFIFGNEMAERMAYFGLSVNMVAFMFYVMHRPFSSSANAVNNFLGISQASSVIGGFLADAYLGRYWTIAIFATIYLAGLTGITLCATMNFFLPNQEQCDQIALLLGNCEPAKPWQMLYLYIVLYLTGFGAAGIRPCVSSFGADQFDERSRDYQSHLDRFFNFFYLSVTVGAIVAFTAVVYVQMKHGWGSAFGSLAIAMGLSNMVFFLGTPLYRHRLPGGSPLTRVAQVLVAAFRKRNASFDSGDFVGLYELPGKRSAIRGSSKIAHTDDFRCLDKAALQLKEDGADPSPWRLCTVTQVEEVKILLKLIPVPLCTVMLNLILTEYLTLSVQQAYTLNTHIGGLKLPVTCMPVFPGLSIFLLLSFYYSVFVPLSRRVTGHPHGASQLQRVGIGLAVSILSVAWAGGFERYRRHYAVEQGYEASFLTPMPDLSAYWLLIQYCLIGIAEVFCIVGLLEFLYEEAPDAMRSIGSAYAAVAGGLGCFAATILNSIVKSVTGNGETRRPSWLSQNVNTGRFDYFYWLLTVLSVINFAAFLYAAHCYQYRKKEHGEMREPSSIQSSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHD2</accession>
    <name>A0A068VHD2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00002113001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Potassium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739428">
        <property type="protein sequence ID" value="CDP19088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHD2"/>
    <dbReference type="FunCoup" id="A0A068VHD2">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VHD2"/>
    <dbReference type="Gramene" id="CDP19088">
        <property type="protein sequence ID" value="CDP19088"/>
        <property type="gene ID" value="GSCOC_T00002113001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHD2"/>
    <dbReference type="OMA" id="IFHGQLY"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHD2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="12">
        <location>
            <begin position="64"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="13">
        <location>
            <begin position="566"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU321113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP19088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="821" mass="91013" checksum="F6DE531DB1C259C6" modified="2014-10-01" version="1">MYTVDIDREEDSDDVLRQQAANGGQNSSRASGPEGRTEPTQVPKRTKNLAAKIPLADLSRNLLLAYQSFGVVYGDLSTSPLYVYKSIFVGKLSSHTNEDAIFGAFSLIFWTLTLIPLLKYTLILLSADDNGEGGTFALYSLLCRHAKFSLLPNQQAADEELSTYKYGPSAQHASSAPLRRFLEKHKKSRTVLLLVVLLGACMVIGDGVITPAISVLSSVSGIKVAENKLTQGEVILIVCVILVGLFALQHCGTHKVAFLFAPVVVLWLISIFALGLYNVIHWNPKIVSALSPHYIVKFFKETGKDGWISLGGVLLAITGTEAMFADLGHFTASSIRIAFTFVVYPCLVIQYMGQAAFLSKNIPSIPRGFYDSIPGSVYWPMFVIATLAAIVASQAIISATFSIVKQCNALGCFPRVKVVHTSRHIYGQIYIPEINWILMIITLAIAIGFQDTTTIGNAYGLACMTVMFITTFLMSLVIVFVWQRNLLFAAAFLLFFWIIEGAYLSAALIKVPQGGWVSLLLSVIFMFIMFVWHYGTRKKYNFDVHNKVPLKWLLGLGPSLGIVRVPGIGLIYSELATGVPPIFSHFVTNLPAFHSVLVFVCVKSVPVPYVSPEERFLVGRICPRPYRIYRCIVRYGYKDIQRDDGNFENLLIQSIAEFIQMEAVEPQFSSSDNASFDGRMAVISTRNVGTNSSLVVSERDDSDEIVSVQSSRSLTLQSLRSAYDDENPQMRRRQVRFQLPESPGMDVSVREELLDLIQAKEAGVAYIMGHSYVKARRSSSYLKKLVIDIGYSFLRKNCRGPAVALNIPHISLIEVGMIYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHI1</accession>
    <name>A0A068VHI1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome C biogenesis protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00009384001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739438">
        <property type="protein sequence ID" value="CDP19128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A068VHI1">
        <property type="interactions" value="345"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP19128"/>
        <property type="gene ID" value="GSCOC_T00009384001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHI1"/>
    <dbReference type="OMA" id="DHYLPFI"/>
    <dbReference type="OrthoDB" id="1902618at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHI1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36394">
        <property type="entry name" value="OS01G0277700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36394:SF1">
        <property type="entry name" value="OS01G0277700 PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP19128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24477" checksum="63BE4A5D308C921B" modified="2014-10-01" version="1">MEKGSFSAEDLSTIGGIATVSLLHSFIPTHWLPFSIVGRAQKWTLSRTILVTAFGAVLHVVSTSLLGITAVTISNTIAGEETVHKLASLLLIFLGGSYVILFLTGKGGHSHSHNQPMEKMAVAGLVLVPALSPCATTLPVFLAVGNSSSMMVLAIIVLLFSTITVMTSLVALSFYGASQLKFHWVERYDKLLVGSVLCLVGMLTLIFHDHHHDGDLVSGGVHHRKLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKB0</accession>
    <name>A0A068VKB0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00009222001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741482">
        <property type="protein sequence ID" value="CDP21057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKB0"/>
    <dbReference type="STRING" id="49390.A0A068VKB0"/>
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        <property type="protein sequence ID" value="CDP21057"/>
        <property type="gene ID" value="GSCOC_T00009222001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKB0"/>
    <dbReference type="OMA" id="PEFYWKS"/>
    <dbReference type="OrthoDB" id="654134at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKB0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF2">
        <property type="entry name" value="BURP DOMAIN PROTEIN RD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01045">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BURP" evidence="1">
        <location>
            <begin position="130"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="342" mass="38434" checksum="95B9A5BCFAC4A554" modified="2014-10-01" version="1">MPKAVRELVHNGKTSGSGSFTKLPDSNFQIYNARAQMNGHGSSFSQLPDSKFQIYNRKSQVNGHGFSFSKLPDSKFQIYNRKSQLNSHGISFSNLPDSKFQIYNRKSQVNSHGTNPTKDQLYNDKNITIFFLGKDLHRGSSMNLEFVESLKITTLFLPRQVADSIPFSSKSVPEILNKFSLKPQSEEAETIKKTIAECEMPGTKGEDKYCATSLESMIDFTTSKLGKDVRAVSTEAEKIDTKIRKYTIKDVAKLNTADKVVSCHKEKYPYAVFYCHTSQSNAYMTNLAAAEDEAKAKAVAVCHKDTSQWDPEHLAFQLLKVKPGTAPICHFLPEDHIIWVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKC5</accession>
    <name>A0A068VKC5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00010687001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of shoot development and salicylic acid (SA) homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741460">
        <property type="protein sequence ID" value="CDP21049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKC5"/>
    <dbReference type="STRING" id="49390.A0A068VKC5"/>
    <dbReference type="Gramene" id="CDP21049">
        <property type="protein sequence ID" value="CDP21049"/>
        <property type="gene ID" value="GSCOC_T00010687001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKC5"/>
    <dbReference type="OMA" id="WIHMWPS"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000015">
        <property type="entry name" value="Protein DMR6-LIKE OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="206"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="357" mass="40096" checksum="7AABB35E11B0B9C0" modified="2014-10-01" version="1">MEDKRESSVSPTSFTSVLKLSQIGAASVPKCYVLPPLLRPNLGLCPNPALVSPIIDLSSLHHPIHGLRIKEEVRLACKDSGFFQVINHGIPLSVMNDALDAATDFFELPHEEKMSLASANIREPVRYGTSLNHVKDRVLFWRDFIKHYSHPISTWIDQWPSNPKTYKEKMGNYTQAVHALHRKLMGVVFENLGLSPKYLHEGIYEGSQVMAVNCYPTCPEPDLVLGMPPHSDYGYMTIILQNHQGLEIMSHDRKWYEVPVRKGALVIQIGDQMEIISNGLCKSLVHRATVNSDTDRISIASLHSLALERKVGPASELLVDDQHPLSYTEGSFSGFLDFISNNDIMEVRYIDALKKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKD8</accession>
    <name>A0A068VKD8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00006030001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741543">
        <property type="protein sequence ID" value="CDP21082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKD8"/>
    <dbReference type="STRING" id="49390.A0A068VKD8"/>
    <dbReference type="Gramene" id="CDP21082">
        <property type="protein sequence ID" value="CDP21082"/>
        <property type="gene ID" value="GSCOC_T00006030001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKD8"/>
    <dbReference type="OMA" id="FHPHTIP"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKD8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF60">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 91B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="117" mass="13308" checksum="4934F7174C5260D4" modified="2014-10-01" version="1">MANESKLHLVMLAWLAFGHFIPFLELSKFIAQRGHRVTFISTPRNIARLPKIPPHLVSSITFVKIPPPQVEGLPKNAEATMDIHTDQMSLLKRAYDGLEPELTRFLENSLPDWTSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKE9</accession>
    <name>A0A068VKE9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_3027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013145001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG742111">
        <property type="protein sequence ID" value="CDP21270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKE9"/>
    <dbReference type="Gramene" id="CDP21270">
        <property type="protein sequence ID" value="CDP21270"/>
        <property type="gene ID" value="GSCOC_T00013145001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKE9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="86" mass="9944" checksum="BE9D4EDDE4DA7D81" modified="2014-10-01" version="1">MASMRIKSLRKEILSCGSKLVEKYNRFVIFPIKSSIVKESLEKRSKKLLIKAKVASNLIIQVGEETFHLYKVPMVPRSRLKKRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKL5</accession>
    <name>A0A068VKL5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSCOC_T00010755001</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG742000">
        <property type="protein sequence ID" value="CDP21236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKL5"/>
    <dbReference type="Gramene" id="CDP21236">
        <property type="protein sequence ID" value="CDP21236"/>
        <property type="gene ID" value="GSCOC_T00010755001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKL5"/>
    <dbReference type="OMA" id="NTRSECK"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKL5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000445">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF126">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658755" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="25"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="414"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDP21236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="744" mass="81337" checksum="B0F1D18A7CC0F938" modified="2014-10-01" version="1">MDVVCSGVVLLMILAVAPVAGAAAKESAVNLLEAEALRKSGWWRGSSATATNISAHCQWYGIVCNDVGSVTEILLSGYGIYEDLTNLELTNFSFSSFRNLVRLDLSGNGLHGAIPDQIGALFKLTYLDLSSNYLYGELLSSLVNLTQLAHLDVSSNWIESLIPPGIGNLTNLVALDLSQNSFGGRIPPTLGQLPYLTSLDLSNNILNGTIPSEIGNLQNLEYLHLGSNRLTGQIPPTLSNLTALGNLDLSSNQISGSIPSEIGNLTALGNLDLSSNQISGSIPSKIGNLKFLEYLNFGSNRLTGQIPPTLGNLTFGSERFDGNPDLHYTSALCGASPPVMKNHRHHPPYYIIRLGVSLLVLSLIGGLVLYIFRKTKVKKVEVELMDNKHGDIFRIWNYDGQMAYEDIIKATNDFDVSYCIGTGGYGSVYRAQLPSGKVVALKKLHRLEGENPNFDKSFRNEADMLSKIRHRNIVKLFGFCLHKRCMFLIYEYMDRGSLFCILRDETEAVELDWIKRVNLIKGIASALSYLHYDCDPPIIHRDVSSNNILLNSKLEATLSDFGTARILVLDSSNQTVIAGTFGYMAPELAYTMVVTEKSDVYSFGVVVLETLFGEHPREFLSCISSQPNGPIMLMDLLDARLPPPTNPLVVRNLVVATALALDCVNANPKCRPTMQQVVNRFEAGRREPTRPLHTIAVNQLVSPPAPLRDQTCADGTSSLSTVNEFHVDIAATLPSSNFSIHAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKR7</accession>
    <name>A0A068VKR7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_1059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00001864001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740143">
        <property type="protein sequence ID" value="CDP20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKR7"/>
    <dbReference type="STRING" id="49390.A0A068VKR7"/>
    <dbReference type="Gramene" id="CDP20263">
        <property type="protein sequence ID" value="CDP20263"/>
        <property type="gene ID" value="GSCOC_T00001864001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKR7"/>
    <dbReference type="OMA" id="WNITHRQ"/>
    <dbReference type="OrthoDB" id="683469at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKR7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010073">
        <property type="term" value="P:meristem maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019557">
        <property type="entry name" value="AminoTfrase-like_pln_mobile"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044824">
        <property type="entry name" value="MAIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46033">
        <property type="entry name" value="PROTEIN MAIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46033:SF8">
        <property type="entry name" value="PROTEIN MAINTENANCE OF MERISTEMS-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10536">
        <property type="entry name" value="PMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase-like plant mobile" evidence="1">
        <location>
            <begin position="58"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="289" mass="34034" checksum="96968CFE18059081" modified="2014-10-01" version="1">MCRLIICVDGTHLRGEYKGKLLVAVTQDANNKILSIAYAIEPLDYHRFCLRHVRSNLITHFNGLHLKNWSSECLATLYRSLCDAANPAKSAIAGPLVLLQIWIWEHIPTIRPDRIAPLEHYPGSYFIKYRWNNDLDVHRVVRHVMPAFRDQLTGLRSQEFIWQPYSEDVLASLSAYCTAGRDIWRSVTCLICWDVVEPYLPHRVMRQFVFHQSLPDMWLTDNHDSLHSLDRRGRANQDWNITHRQYIDIWTDRRVHVQDGIVIEDTKYPSDEYVQWYQERTVIYISNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKR9</accession>
    <name>A0A068VKR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00001964001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG741789">
        <property type="protein sequence ID" value="CDP21182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VKR9"/>
    <dbReference type="STRING" id="49390.A0A068VKR9"/>
    <dbReference type="Gramene" id="CDP21182">
        <property type="protein sequence ID" value="CDP21182"/>
        <property type="gene ID" value="GSCOC_T00001964001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKR9"/>
    <dbReference type="OMA" id="NWYSRED"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKR9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12873" checksum="63BBB1C60338E574" modified="2014-10-01" version="1">MVGFFAYAKSLEINVDKEELEDAKWHSREDVKKALTFAEYKKAQRTAADRVDQICKGVEKGQNLSADFSVESGELASMFIPGPFAIAHHLISSWANQVVVNGAETHGKQPGSYLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VL28</accession>
    <name>A0A068VL28_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_3159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00012616001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG742243">
        <property type="protein sequence ID" value="CDP21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VL28"/>
    <dbReference type="Gramene" id="CDP21289">
        <property type="protein sequence ID" value="CDP21289"/>
        <property type="gene ID" value="GSCOC_T00012616001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VL28"/>
    <dbReference type="OMA" id="GWYYATV"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VL28"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="623" mass="69089" checksum="0F78C00202E21BAB" modified="2014-10-01" version="1">MKRPLEEKKDMVKEPLLSTASPKGGSGTMPFIIANSVLEKVATYGVSPNMTLYLLKEYHLEMATASNILFYLSAANNFTPVLGAIVADAYVGRFHMIGFGCVISFLLIFGQISDKQEERGNSFGRGKGEFGFRFPIPRTSTSTTFLHLLGTIVLWLTTMIPQARPPPCNESSNSCTSATSFQLFMLFTSFILLSVGAGGIRSASLAFGADQFEKRDGKKDAVLLQRYFSWYYVSYSLSLVLALTCMVYIQDQMGWQIGFGASVVVMFFAAFLFFLASPFYIKVKAKVTLFTELVQVIVASYKNKSRKLLSSSSTEMLYHHKNGSMLVFPSEKMRFLNKACIIHDPEQDLTPDGRAKNPWNLCTVDQVEDLKALLKVIPIWLSGIVTFININQTSFSVLQASSMDRKIIGNFEIPAGSFGIFNIISMILWVAFYDQVLLPIAARIKGKPVYLTARQRMGIGTFISFLSVVVTATVECIRLSLAFKEGISDDPEAIVHMSALWLLPQYCLIGLTLGLSAIAQNEFFISELPRSMSSMASTLCGVGISLGCLVASFIMSAIDDFTKRGGGESWISTNINKGHYDYYFWVLSGLSLANFFFFLICCWTYGPCRGEEGNVNDEEVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLD3</accession>
    <name>A0A068VLD3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_4625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00000197001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG743709">
        <property type="protein sequence ID" value="CDP21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLD3"/>
    <dbReference type="STRING" id="49390.A0A068VLD3"/>
    <dbReference type="Gramene" id="CDP21511">
        <property type="protein sequence ID" value="CDP21511"/>
        <property type="gene ID" value="GSCOC_T00000197001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLD3"/>
    <dbReference type="OrthoDB" id="1710643at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="99" mass="11168" checksum="A20FF329E311EDF7" modified="2014-10-01" version="1">MDFENYYEISLVADFINAHNFSRVALQFPDELLKDSRKVVSALRQELHRPLQNSDESRATAKLYVMADTTYGSFCVDEVGAAHVKADCVIHYGHSCLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLJ4</accession>
    <name>A0A068VLJ4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_4941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00011722001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG744025">
        <property type="protein sequence ID" value="CDP21571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLJ4"/>
    <dbReference type="Gramene" id="CDP21571">
        <property type="protein sequence ID" value="CDP21571"/>
        <property type="gene ID" value="GSCOC_T00011722001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLJ4"/>
    <dbReference type="OMA" id="MANMEEN"/>
    <dbReference type="OrthoDB" id="1898501at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLJ4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="105" mass="11309" checksum="2292160DB01C26C7" modified="2014-10-01" version="1" fragment="single">MATVEEKGRPVEKIKGGMVTMPFIFANEVCEKLAVVGVGSNMQSYLTKQLHMSLTKAANTTTNFSGTASLTPLIGAFIADSFAGRFWTITVASIFYQIVKSLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLR5</accession>
    <name>A0A068VLR5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH200=94 genomic scaffold, scaffold_4832</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00003284001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743916">
        <property type="protein sequence ID" value="CDP21557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLR5"/>
    <dbReference type="FunCoup" id="A0A068VLR5">
        <property type="interactions" value="2500"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLR5"/>
    <dbReference type="Gramene" id="CDP21557">
        <property type="protein sequence ID" value="CDP21557"/>
        <property type="gene ID" value="GSCOC_T00003284001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLR5"/>
    <dbReference type="OrthoDB" id="871577at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000005">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP21557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="19690" checksum="6035C1579125FB20" modified="2014-10-01" version="1">MVKYSREPDNPTKSCKARGSDLRVHFKNTRETAHAIRKLPLAKAKRYLEDVLAHKQAIPFTRFCGGVGRTAQAKNRHSNGQGRWPVKSAGFILDLLKNAESNAEVKGLDVDSLFISHIQVNQAQKQRRRTYRAHGRINPYMSSPCHIELILSEKEESVKKEPESQLATSKSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMH1</accession>
    <name>A0A068VMH1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_7602</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00000740001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG746686">
        <property type="protein sequence ID" value="CDP21901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMH1"/>
    <dbReference type="STRING" id="49390.A0A068VMH1"/>
    <dbReference type="Gramene" id="CDP21901">
        <property type="protein sequence ID" value="CDP21901"/>
        <property type="gene ID" value="GSCOC_T00000740001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMH1"/>
    <dbReference type="OMA" id="XLLIGSS"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMH1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP21901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20103" checksum="FEBE98D08E841B90" modified="2014-10-01" version="1">MGIIEKIKEIEAEMARTQKNKATEYHLGQLKAKIAKLRTQLLEPPKGSSGAGDGFEVTKYGHGRVALIGFPSVGKSTLLTMLTGTHSEAASYEFTTLTCIPGIIHYNDTKIQLLDLPGIIEGASEGKGRGRQVIAVSKSSDLVLMVLDASKVSFDLFHRSYIMIRFSSVKMLFQFLRLLKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMW1</accession>
    <name>A0A068VMW1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DH200=94 genomic scaffold, scaffold_10305</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00009908001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG749389">
        <property type="protein sequence ID" value="CDP22100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMW1"/>
    <dbReference type="Gramene" id="CDP22100">
        <property type="protein sequence ID" value="CDP22100"/>
        <property type="gene ID" value="GSCOC_T00009908001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMW1"/>
    <dbReference type="OMA" id="CECNFAG"/>
    <dbReference type="PhylomeDB" id="A0A068VMW1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="7">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="8">
        <location>
            <begin position="332"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP22100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="706" mass="80399" checksum="993950E09790CFAB" modified="2014-10-01" version="1" fragment="single">MNDGPYFLGKLSGDECWSIIKGKVMSAGEEVPEELEALKKQILRRCDGLPLAASLIGGLLLTNRREKWHSIVQESLLNECQTEIEQILKVSFDHLSPASVKKCFAYCSIFPQDTELEQDQLIEHWVAEGFVLPDQKNNRVMEETGGEYLRILLQNSLLEKVQESYYKMHDLVHDFAKSILNPESSNQDRYLALDSSKASIRTLFLHLEGGITTDMLLRFKCLNVLKLSGYDVKFLPSSIGKLPHLRLLDISSSRIRSLPESLCKLYNLQTLTMRDGVLQGGFPKRMSDLISLRHLNYDDYRAELKMPAQMGLLTCLQTLEFFNVSQERGRGIEELGTLKYLKGWLRIRNLGLVKGKEAAKQAKLFEKPDLSCLVFKWESGDRESDNRDEDVLEGLQPHPNLQRLEIGSFMGNKFPQWLINLSKLEALRIEDCKRCSELPSLGQLPSLKSVYLTRLDNIRFIGDEFYGSSSRRRKFFPALEVLYVEYMENLVEWKDADQVRSKIGEAEADVFPMLRNFNIHSCPQLTTLACSLNGQKCPLPCLEKLSIHNCEGLTALSDKMFQSCRSLRSLKVGCCPNLVSFSLNLQETPSLEEFALVDCPKLIPHSFKGFAFATSLRRLTINKGLPHTESLPHQLQYLTTLTSLSLHNFRGIEVLPDWIGDLVSLETLGLSDCDKLRSLPSEAAMRRLTKLTRVDVFDCPLLRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNK6</accession>
    <name>A0A068VNK6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_13145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013156001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG752229">
        <property type="protein sequence ID" value="CDP22266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNK6"/>
    <dbReference type="STRING" id="49390.A0A068VNK6"/>
    <dbReference type="Gramene" id="CDP22266">
        <property type="protein sequence ID" value="CDP22266"/>
        <property type="gene ID" value="GSCOC_T00013156001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNK6"/>
    <dbReference type="OMA" id="GFGQQNE"/>
    <dbReference type="PhylomeDB" id="A0A068VNK6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="102" mass="11966" checksum="A423DCD7574854DA" modified="2014-10-01" version="1">MADYHFVYKDLEGASTQWDDIQRKLGNLPPKPPAFKPPSFTPAEDPDSKPKDKAWVDDKTEEELEDLEDDLDDDRFLQEYRYLLTFFIFWGGGPFDFPVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLY2</accession>
    <name>A0A068TLY2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00014442001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLY2"/>
    <dbReference type="STRING" id="49390.A0A068TLY2"/>
    <dbReference type="Gramene" id="CDO97181">
        <property type="protein sequence ID" value="CDO97181"/>
        <property type="gene ID" value="GSCOC_T00014442001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLY2"/>
    <dbReference type="OMA" id="YHTINKQ"/>
    <dbReference type="OrthoDB" id="641808at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLY2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865:SF22">
        <property type="entry name" value="DUF1685 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31865">
        <property type="entry name" value="OSJNBA0071G03.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO97181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="158" mass="17679" checksum="D9D865D9C16DA232" modified="2014-10-01" version="1">MDHVSALSAKPLSETKSGPPDMQREAAWLKRKKEFRRWQRRRCKSFTDSDLDELRACIELGFGFEFDSADLDPKLSSAFPALDFYCAVNKQFHSRSDSLSRSSSSVTVASSDSDTSRSSAGSSSSSLFEPGDDPEVKKTRLRQWVQVVACTVRQCSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM58</accession>
    <name>A0A068TM58_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00014575001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM58"/>
    <dbReference type="STRING" id="49390.A0A068TM58"/>
    <dbReference type="Gramene" id="CDO97291">
        <property type="protein sequence ID" value="CDO97291"/>
        <property type="gene ID" value="GSCOC_T00014575001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM58"/>
    <dbReference type="OMA" id="QHIAAMY"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM58"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO97291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="528" mass="57784" checksum="A59ECA604751C6C7" modified="2014-10-01" version="1">MTVPAKGDELVPHPVKDQLTGIDYCVNSNPSWLEAVILGFQHFLVMIGTIVIIATIIVPQMGGGNVEKAQVIQTMLFVSGVNTLLQTWLGTRLPVVMRGSFTYIIPALFVALASRFNVYVNPRQRFKNTMRAVQGAVMLSSILPILIGFLGLWRIVVRLISPLSAVPLVTLVGLGLYEHGFPLLAQCIEIGLPELIILVLLSQYTPHFYKLNRPIFDRFAVLIAVGLVWAFAALLTVAGAYKNRPPQTQFSCRVDRSGLISGASWIRFPYPWQWGTPSLHVGEAILMLAAAFVSVVESTGAFIAAARFGSATHTPPSVLSRGVGWLGIAILFDGLWGTGSGSTVSVENVGLLALTRVGSRRVIQISAVFMLFFSILGKFGAVLASIPLPIVGALYCVLFALMSSAGLGLLQFCNLNSFRTKFILGFSFFMGLSVPQYFNGYVLTSGHGPVNTHSLWFNKLMTVVFTSPATVAGIVALFLDLTLARKHSLTRKDSGRHWWAKYRTFERDPRSEEFYGLPFGLTKYFPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNQ8</accession>
    <name>A0A068TNQ8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MORF/ORRM1/DAG-like MORF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00014961001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
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                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
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        </location>
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        </location>
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            <end position="253"/>
        </location>
    </feature>
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            <end position="268"/>
        </location>
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            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO97579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="439" mass="50078" checksum="100B46CBB6B32384" modified="2014-10-01" version="1">MALCSLRLRRALSLSSFLLHQHFHSPKFLSPLHSSSSALFGPQNPRTTPSFSDFHSFRHFRSSPISLSSRNRRFESDDQMEITADTILFEGCDYNHWLITVDFPRDVDIPAEQKVQKYVEIAAGVFGSEEEAKKRIYACSTTTYQGFQVECSEETSEKFKENPAVVFVLPDSYIDPVNKEYGGDKYINGTIIPRPPPIMSVRRNPRQFSRPQRPENWGSGPGDARNFGPQQSHPSQQNFGPQQNHPTQQNFGPRQNHTTQQNHPTQQNFGPQQNYTAQQNFGPPRGPVSQQNYSPPQNTPPQQTYGQQQNAPPRQYYGTPENTTAHQNYGYHSPQHNYGQDRRSKLHAFTRWDLSSGHRRSSSTGNGPCIWAELPKARRRSEILRGRPEKQIPEWGPKEFCLTMGGAKKKKSTLPMRFGNQKCREDSMWTNSSLLCCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TNT8</accession>
    <name>A0A068TNT8_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00021844001</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="176"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
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            <end position="267"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="429" mass="44471" checksum="BEC62C95DBB373C1" modified="2014-10-01" version="1">MDYDYVAAEQNFSAYGVDEQQSHHRQGGGEDEYEEDNHGEDYYSERGGGGGGIGGGGGELEPLDNIDDSTTAGHDLKHSVDDSSAGKLFVGGIAWETSEESFSRYFSKYGELTDSVIMMDKISGRPRGFGFVTFADPEVANKVLEEEHIIDGRTVEVKRTVPREDMQGRGGVSRTKKIFIGGIPLTLTEDELREYFSAYGKVVEHQIMLDHKTGRSRGFGFVTFETEDAVEKIFTDGQMHELGGKQVEIKKAEPKRSGYDHSSDSRMRRGGSNSNKSYGGGYSGGADGFGGGYGGKMGRGYGGYGGYGGYGGYGNYAGNYGGGAGFYAGYGGFGYGFGFGGPMYGGAGYGASSYGAPGGYGGAAAGYGSGRGYGSGYDGGKSYGGSGGSGSAAGYGGPKGYGGGGGSGSGGSKGYGNGGASGRFHPYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TP89</accession>
    <name>A0A068TP89_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00021609001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TP89"/>
    <dbReference type="STRING" id="49390.A0A068TP89"/>
    <dbReference type="Gramene" id="CDO97729">
        <property type="protein sequence ID" value="CDO97729"/>
        <property type="gene ID" value="GSCOC_T00021609001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TP89"/>
    <dbReference type="OMA" id="ASTICCQ"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TP89"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO97729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="13638" checksum="CC9B15360AB86DA6" modified="2014-10-01" version="1">MAKLVFAKSIWSYVCRMSDALRIYSPQLNSSLSATMLTQKFPPGMEGVDDTSSAASTICCQLASDCYTSNISRKPANKLIKNGLILLGGAVCLSGGHSDLGAKIAMAYILTKLTKHGALSRLRKAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPF5</accession>
    <name>A0A068TPF5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00022130001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPF5"/>
    <dbReference type="STRING" id="49390.A0A068TPF5"/>
    <dbReference type="Gramene" id="CDO98131">
        <property type="protein sequence ID" value="CDO98131"/>
        <property type="gene ID" value="GSCOC_T00022130001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPF5"/>
    <dbReference type="OrthoDB" id="8891264at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPF5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF181">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO98131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="123" mass="14830" checksum="7D190739442BE7EF" modified="2014-10-01" version="1">MKQLHYNLSYLKVRFEEFKNEILLIAKLQHKNLVRLLGYCLEGEEKTLIYERFPNRIRNTSLTTSNHTEVMKDINAIRDHRRKVQKLLYLHEDTLLRIIHRDLKRSMLYQNSPSLDANIHICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPW0</accession>
    <name>A0A068TPW0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00022417001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPW0"/>
    <dbReference type="STRING" id="49390.A0A068TPW0"/>
    <dbReference type="Gramene" id="CDO98350">
        <property type="protein sequence ID" value="CDO98350"/>
        <property type="gene ID" value="GSCOC_T00022417001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPW0"/>
    <dbReference type="OMA" id="TIVIMAC"/>
    <dbReference type="OrthoDB" id="2017960at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPW0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051258">
        <property type="entry name" value="Diverse_Substrate_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920:SF10">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920">
        <property type="entry name" value="OS03G0707200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="146"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="281"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO98350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="486" mass="53093" checksum="3C9F4C34A829D77C" modified="2014-10-01" version="1">MPYFSTWRASRDTAAAAATVSCYLNSYGIRKISHLKVYSYSDPSSSSSSNPSSSSSSSSSSSSSSSSSVHSWSAASRKILAERSSRSGRNFDGAFSIIETETCKVETKTKSNESSKGPSKIKANKSSIRRRPLWRKLLFGSKKFRSIILLNVVSVVYASNILVVKETEALMDPAAFSAVRFAVSAIPFLPFVFRARNDAQTRKAGMELGLWISLGYLIEALGLLTAEAGRASFLSLFTVIVVPLLESMLGTIVPARTWFGILMSVVGLGLLECSGSPPNVGDLLNFLSAIFFGIHTLRTEHISRSTRQENFLALLGYEVSVVALLSAIWCLIGGSFDGFQYTENVSWTWALVWDWMVTFPWIPTLYTGVFSTGLCLWAEMAAMRDVSATETAVIYGLEPIWGAGFAWFLLGERWGTAGWIGAALILGGSLSAQMNEYLPNEFRKVGKNDEKLNLLTIPDNQGKRNTNLSASPVVVRSKDVIDVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQ26</accession>
    <name>A0A068TQ26_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00022412001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the plant CAR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQ26"/>
    <dbReference type="FunCoup" id="A0A068TQ26">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQ26"/>
    <dbReference type="Gramene" id="CDO98346">
        <property type="protein sequence ID" value="CDO98346"/>
        <property type="gene ID" value="GSCOC_T00022412001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQ26"/>
    <dbReference type="OMA" id="CAESHIM"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQ26"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04038">
        <property type="entry name" value="C2_ArfGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044562">
        <property type="entry name" value="CAR1-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45933">
        <property type="entry name" value="PROTEIN C2-DOMAIN ABA-RELATED 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45933:SF5">
        <property type="entry name" value="PROTEIN C2-DOMAIN ABA-RELATED 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO98346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="164" mass="18654" checksum="9268901AA8801992" modified="2014-10-01" version="1">MDNLLGLLRIRVKRGVNLAVRDVRTSDPYVVVKMGKQKLKTRVINKDVNPEWNEDLTLSVSDPNIPVKLTVYDHDMFSKDDKMGEAEFDIKAFIEALKMKLNGLPNGTIVSRVIPLRTNCLSEESCVIWKDGKITQDMCLRLRNVECGEVEIQLQWIDLPGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQH3</accession>
    <name>A0A068TQH3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00015000001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQH3"/>
    <dbReference type="STRING" id="49390.A0A068TQH3"/>
    <dbReference type="Gramene" id="CDO97613">
        <property type="protein sequence ID" value="CDO97613"/>
        <property type="gene ID" value="GSCOC_T00015000001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQH3"/>
    <dbReference type="OMA" id="FHKFVGQ"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQH3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000008">
        <property type="entry name" value="tRNA pseudouridine synthase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="64"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="216"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO97613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="378" mass="42116" checksum="FA69305642436553" modified="2014-10-01" version="1">MSADQSRQSLNRRPGNHSPERPQKIARVNPIGESGCEEEENQRKGPIVTETKMNPNPRVQRYLIAIEYIGTRFAGAQQQSNCRTVVGVLEEAFHKFIGQPVSIFCSSRTDAGVHALSNVCHVDVERISKRKPGETLPPHEPAVVKKAVNHFLQKNEGDIMVIDVQSVPSDFHSRYKAQERTYFYRLLSGPEPLSTFEKDRAWHVAEELDLLSMQKACQVLVGRHDFSSFRAAACQAKSPIRSLDELNVTEVVSPLSFPSIKEREQSNYLVEDSFATSLKSESEVSHVSSTITSQVEPIPTFGMRKQHRCFVVTARARSFLYHQVRLLVGVLKSVGTGNLTVDDVERILKAKTVAAASPMAPACGLYLGHVKFDLASDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR50</accession>
    <name>A0A068TR50_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knottin scorpion toxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00022858001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR50"/>
    <dbReference type="Gramene" id="CDO98681">
        <property type="protein sequence ID" value="CDO98681"/>
        <property type="gene ID" value="GSCOC_T00022858001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR50"/>
    <dbReference type="PhylomeDB" id="A0A068TR50"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657255" description="Knottin scorpion toxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO98681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8597" checksum="87A943FAB335DEAC" modified="2014-10-01" version="1">MSKVLLLCCILSLLFVMNLAEEVPNAGGLEDSKVTLKHLGLRSSVAQCVRDCHARWPNSTARCPFLHGHRCACLCYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSC3</accession>
    <name>A0A068TSC3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">xyloglucan 6-xylosyltransferase</fullName>
            <ecNumber evidence="12">2.4.2.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00025824001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-(1-&gt;6)-D-xylosyl-D-glucose linkage.</text>
            <dbReference type="EC" id="2.4.2.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.39" evidence="12"/>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO98874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSC3"/>
    <dbReference type="FunCoup" id="A0A068TSC3">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSC3"/>
    <dbReference type="Gramene" id="CDO98874">
        <property type="protein sequence ID" value="CDO98874"/>
        <property type="gene ID" value="GSCOC_T00025824001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSC3"/>
    <dbReference type="OMA" id="GWNEMIY"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSC3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033843">
        <property type="term" value="F:xyloglucan 6-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009969">
        <property type="term" value="P:xyloglucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000032">
        <property type="entry name" value="xyloglucan 6-xylosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF5">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO98874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="460" mass="53676" checksum="FA07AC49CD19FA59" modified="2014-10-01" version="1">MLERCLSPRRARQMQRLLRNGKLTLLCLFLTVIVLRANLGAGKFGTPEQDLNDIRETFSYIRRRAEPRRVLEEARQTFTATDNGASDTNSYADFDIKRIIADEDDGDEVVYKRDPNQPYSLGPKISNWDQQRAEWLKKNPNFRNFVAPNKPRVLLVTGSSPKPCENPVGDHYLLKSIKNKIDYCRLHGIEIFYNFALLDAEMSGFWAKLPLIRKLLLSHPEVEFLWWMDSDAMFTDMAFELPWERYKDHNFVMHGWNEMVYDQRNWIGLNTGSFLLRNCQWSLDILDTWAPMGPKGKIRDEAGELLTRELKDRPVFEADDQSAMVYILTTQREKWAEKVYLESAYYLHGYWGILVDRYEEMIENYHPGLGDHRWPLVTHFVGCKPCGKFGDYSVERCLKQMDRAHNFADNQILQMYGFTHKSLASRKVKRTRNETSNPLEAQDELGLLHPAFRAVKVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TSY4</accession>
    <name>A0A068TSY4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00026493001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TSY4"/>
    <dbReference type="FunCoup" id="A0A068TSY4">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TSY4"/>
    <dbReference type="Gramene" id="CDO99356">
        <property type="protein sequence ID" value="CDO99356"/>
        <property type="gene ID" value="GSCOC_T00026493001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TSY4"/>
    <dbReference type="OMA" id="QTYMFKE"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TSY4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.80:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000113">
        <property type="entry name" value="Putative haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO99356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31385" checksum="C678EC1C67F036C5" modified="2014-10-01" version="1">MFNGLNPPHYHTIPTLPLVSAPNFHQMPLLPALSRAIFSSSVHPLPRSFSSMSNFVTPSSSSVKARLRGVVFDMDGTLTVPAIDFPAMYKAVLGEEEYVSIRKQKPSGIDILQQIEDWSPDKQRQAYEIIADYEKQGLDRLEIMPGASELCAFLDSRSIRRGLITRNVKTAVDLFHERFGKTFSPALSREFRPYKPDPAPLLHICSTWEVRPSEVMMIGDSLKDDVACGNRAGTFTCLLDETGKYDSPKYEHVEYKPDYKVSCLADIHSLLEANFELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTH7</accession>
    <name>A0A068TTH7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029240001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTH7"/>
    <dbReference type="FunCoup" id="A0A068TTH7">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TTH7"/>
    <dbReference type="Gramene" id="CDO99600">
        <property type="protein sequence ID" value="CDO99600"/>
        <property type="gene ID" value="GSCOC_T00029240001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTH7"/>
    <dbReference type="OMA" id="NDVSWTF"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000036">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="56"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="318" mass="35749" checksum="FE4B491BB2ABAE57" modified="2014-10-01" version="1">MGEDHQEALKTELYYWGTTPEDEYFDLHGIKSTKSFYTSPRGVTLFTKSWLPPNNQPRGVIFMVHGYGNDISWTFQATTIFLAQNGYACFAVDLEGHGKSEGLKAYVPNVDLVVDDCLSFFNFILSQNPTFQNLPKFLYGESMGGAICLLIHFKIPTLFNGAILIAPMCKISEKVRPRWPIPEILTIVARFAPTLPIVPTADLIEKSVKVPEKKITAVSNPSRYNGKPRLGTVLELLRVTAYINSRLSDVNLPFLVLHGSADVVTDPQVSMELYELANSKDRTIKIYDGMLHSLLYGEPDENIEIVRGDILKWLNDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUH1</accession>
    <name>A0A068TUH1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00029679001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUH1"/>
    <dbReference type="STRING" id="49390.A0A068TUH1"/>
    <dbReference type="Gramene" id="CDO99950">
        <property type="protein sequence ID" value="CDO99950"/>
        <property type="gene ID" value="GSCOC_T00029679001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUH1"/>
    <dbReference type="OMA" id="QFICDLY"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUH1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31365">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31365:SF2">
        <property type="entry name" value="OS01G0771100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO99950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26454" checksum="079509788B185FD5" modified="2014-10-01" version="1">MWRKALVSYAGGVLLKQPWWRTIAARLSSSSKATSSSVAVNSILLRSLKDHYLEVSKMTPPPKVSPPSPFTVVTGSIDSGGAVLKRSYGEEEIGISVMRLANIIPGGGEDDDEEDDGMNQLFVHVEISKPGQQDSLHFLCGLYPDALGIHSVSMRSKMESSEAAALPVLLSRYNGPTFEHLDEKMRDALHGYIEERGINESLFPFLQAWLYVKDHRNLMRWFKSVGTFVTQAKEGASPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVQ7</accession>
    <name>A0A068TVQ7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00029916001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DVL/RTFL small polypeptides family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVQ7"/>
    <dbReference type="FunCoup" id="A0A068TVQ7">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TVQ7"/>
    <dbReference type="Gramene" id="CDP00117">
        <property type="protein sequence ID" value="CDP00117"/>
        <property type="gene ID" value="GSCOC_T00029916001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVQ7"/>
    <dbReference type="OMA" id="HGRCAFT"/>
    <dbReference type="OrthoDB" id="602011at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012552">
        <property type="entry name" value="DVL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051525">
        <property type="entry name" value="DVL_RTFL_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33102">
        <property type="entry name" value="DVL19-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08137">
        <property type="entry name" value="DVL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="89" mass="10279" checksum="9EA768BF4D9A0A70" modified="2014-10-01" version="1">MASSITAAPTQVAAPPPQFYFDEKWKLSKKESSSRSCRSSSSLIKNPSTTKRCAFTRKCARLVKEQRARFYIMRRCVTMLICWRDYSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWM4</accession>
    <name>A0A068TWM4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450 704B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00032275001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWM4"/>
    <dbReference type="FunCoup" id="A0A068TWM4">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWM4"/>
    <dbReference type="Gramene" id="CDP00359">
        <property type="protein sequence ID" value="CDP00359"/>
        <property type="gene ID" value="GSCOC_T00032275001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWM4"/>
    <dbReference type="OMA" id="EMIPGPT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TWM4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016713">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000119">
        <property type="entry name" value="Alkane hydroxylase MAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP00359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60230" checksum="B6652DF1438214C8" modified="2014-10-01" version="1">MEILIFVACMVILVSWVLIHRLKQRNVKGCPKTWPLVGAAIEQLLNYDQMHDWILKYLARSRTVVVPMPFTTYTYIADPTNVEHVLKTNFGNYPKGDTYHSYMEVLLGNGIFNVDGELWRKQRKTASFEFASRNLRDFSTVVFREYSLKLSEILSKASHQKQEIDMQELLMRMTLDSICKVGFGAEIGTLAPELPDNRFAQAFDTANIIVTLRFIDPLWKIKKFLNVGSEAVLDQSIKIIDDFTYSVIRRRKAELEEAQGANKDAKIKHDILSRFIELSKDPDNHMTDKSLRDVVLNFVIAGRDTTATTLSWAIYMIMTHEDVAEKIYEELKTLEESRAKEENIILQPYQRDDFESFNKRVMQFAGLLNYESLGRLFYLHAVITETLRLYPAVPQDPKGILEDDILPDGTRVKAGGMVTYVPYSMGRMEYNWGPDAASFKPERWLKEGCFQSASPFKFTAFQAGPRICLGKDSAYLQMKMALAILCRFYRFKLIPGHVVKYRMMTILSMAHGLKVSVSRHPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX51</accession>
    <name>A0A068TX51_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00034310001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX51"/>
    <dbReference type="STRING" id="49390.A0A068TX51"/>
    <dbReference type="Gramene" id="CDP00875">
        <property type="protein sequence ID" value="CDP00875"/>
        <property type="gene ID" value="GSCOC_T00034310001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX51"/>
    <dbReference type="OrthoDB" id="1925304at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177:SF365">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN NPR4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24177">
        <property type="entry name" value="CASKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="640"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP00875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="822" mass="93078" checksum="98D788751324E9B4" modified="2014-10-01" version="1">MADLVVDETLRAEMAADPILDKVRGERFRKMKEVQLDPTKLGEGGQQITIPKLYRAAMEGNWEKACRQFDDNQDAKTAKISNLGMTALHVAASCGRSKFVQKLVEELSEQLEARDQLGRTALHHVALAADVNAAKAMVTKNPILPYLGDVNRLTPLFYAAKWRHPSQSKRMVEYLCQVITENENVPVLLEGGDVCNAFTDASAPDLIVAITASGSYGEPGRRTDKPYTALRILERYPELALKKDDKGKSILHVLAMKPKAFRKGNKLSPLISWMYNLVPVDKEETEHEDSTIDGAKSKNRCSAASCFKYMCKFIKGIIEMSDIKQSHVHAVRLVKFVCDKLHEKEEEKEKDKKMDFDPDFSNLEEKIQLEEEREQEEGKEEEKERAQEKGKEREEEEKEREQEKGEEKEREGEEEMDFVQDFFIPKNSTAILHLAVENGVFELVDECLKAFPDLIWYADKPPKVEESVQRRHAHYTSEVVGRLLWKDATQHEHASTSTAKLYHHGTEYADTTSGHWEWHEGQYADTATRTGRLLLHVAIEHRRVEIFNYLIKLIGKNTKAYADLKLEGNNNSLHLAAKLAPTPQLQAVPGPAFQMQRELQWFRAVEEIVYDELKTEKNLDDKTPRELFFNEHKDLLKDAKEWMKDTSNSCMVVATLVATVAFAAMITVPGGNNSNTGLPILAREKLFVAFSISNALSMVSSAVSLLMFLSIQTSRYTEGDFLDSLPKKLLRGLLSLFIAIATMMVSFGTAIGLSLQTRLNWSYIPITIIACVPVIIFTWLQLPLLLQAIRVESGPGIFQGQRDLKLWSIEKIGCSLLAYDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX60</accession>
    <name>A0A068TX60_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00034323001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX60"/>
    <dbReference type="FunCoup" id="A0A068TX60">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TX60"/>
    <dbReference type="Gramene" id="CDP00885">
        <property type="protein sequence ID" value="CDP00885"/>
        <property type="gene ID" value="GSCOC_T00034323001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX60"/>
    <dbReference type="OMA" id="PAIDFCK"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX60"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP00885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="193" mass="22644" checksum="A7684775D8372621" modified="2014-10-01" version="1">MRYTKKRRKGTKQHRKDEGGILIDWLIEVHYKFELMDETLYLTFNLIDRFLKTVSVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILISDRAYSRNDMLEIESLMINTLQFNLLVPTPYVFMRHFLKAAQSNKKLELLSFFIVKLCLFEYEMLRFPPSLLAAAATIFTAQCSVNGFKKWTKICSRHTNYIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXC6</accession>
    <name>A0A068TXC6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00029774001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDP00018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXC6"/>
    <dbReference type="STRING" id="49390.A0A068TXC6"/>
    <dbReference type="Gramene" id="CDP00018">
        <property type="protein sequence ID" value="CDP00018"/>
        <property type="gene ID" value="GSCOC_T00029774001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXC6"/>
    <dbReference type="OMA" id="RIGVIKC"/>
    <dbReference type="OrthoDB" id="1939111at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXC6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000221">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase PXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF5">
        <property type="entry name" value="PROTEIN TOO MANY MOUTHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP00018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18262" checksum="5CFDD08CF37DA069" modified="2014-10-01" version="1">MALRVALGRAKPWGLGYQLVLKCKLGFLGALKNLSLPFNNFIGSLRESLSKMVSLETLDVSSNNLSGVLSNCSMLESLDLSFNYLTGTIPSRLESLSQLRDLIAWLNQLYGEIPQELMYLRRLENLILDFNDLNGSIPASLSNCTNLNWISLSNNQFSGQILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY62</accession>
    <name>A0A068TY62_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DOG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00034718001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY62"/>
    <dbReference type="FunCoup" id="A0A068TY62">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TY62"/>
    <dbReference type="Gramene" id="CDP01171">
        <property type="protein sequence ID" value="CDP01171"/>
        <property type="gene ID" value="GSCOC_T00034718001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY62"/>
    <dbReference type="OMA" id="MYIRSAP"/>
    <dbReference type="OrthoDB" id="2015618at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000019">
        <property type="entry name" value="BZIP family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DOG1" evidence="9">
        <location>
            <begin position="146"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP01171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="362" mass="40571" checksum="91270814FC2071C0" modified="2014-10-01" version="1">MMNMASSTQFAPSRRMGIYDAVQQMSMWEDTFRAHMTPDTGVSIFTKADPSLSSKSECTSKEPLIPPIESQATRSISDKVLRRLAQNREAARKSRLRKKAYVQQLETSRLKLAQLELEIDRARQQGACIGGAVANVGFTGSINPGIAAFEMEYGHWVDEQQKKTSELRNLLQSPISDLELEMVVDNLLNHYHDLFRMKADAAKADVFYLVSGVWRTSVERFFQWIGGFRPSELVNILMPALEPLTDQQLVDVCNLRHSCQQAEDALSQGIDKLQQNLAQSIAADPMVVGNYGSQMASSIEDLEALETFVNQADHLRQQTLQRMSSLLTTRQAARGLLAFGEYFQRLRALSSLWAARPHDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYU1</accession>
    <name>A0A068TYU1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Insecticidal crystal toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032489001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYU1"/>
    <dbReference type="FunCoup" id="A0A068TYU1">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYU1"/>
    <dbReference type="Gramene" id="CDP00528">
        <property type="protein sequence ID" value="CDP00528"/>
        <property type="gene ID" value="GSCOC_T00032489001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYU1"/>
    <dbReference type="OMA" id="WYSPFFL"/>
    <dbReference type="OrthoDB" id="647907at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYU1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010683">
        <property type="entry name" value="DUF1262"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31050:SF3">
        <property type="entry name" value="OS08G0412800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31050">
        <property type="entry name" value="OS08G0413200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06880">
        <property type="entry name" value="DUF1262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45206" checksum="EBF421210821FC87" modified="2014-10-01" version="1">MYVARPLSEYTKNPDTLSLPPEGPNSGYLVIQDEESETYSCFGLCKNRTVRDLPFPQNKNLTVQYVQGSGESQDVSLDDAVFIPVLNLPLSSNRYYVIKPHGNHKGKAVTCSREEDKTTCCFCRCVKDIKPRPFDPKNIYQQFEVFVYEAACVGRGYFYAKSVAPDGFPPYFLRRKGWSVHTKTPKHYELDEAPGLNASLRARLPEFSVPPSYKSSEAVVVGKWYSPFLFIKDGIVKDQMKRSMFYQVTLEQKWEQVYSTQNSYHEAKSVSMDVTIDREAVYIAGNKAVWDEKNVVEGAIWFKSFGRAGEEATVGLSIELVQRMKWEQERAGWLGGNERQVRVERIEYSGEKGEWREFGCFVLVESFVFKRMDGSLLMTYDFKHPHQIKCTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0N6</accession>
    <name>A0A068U0N6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PC-Esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00036830001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0N6"/>
    <dbReference type="FunCoup" id="A0A068U0N6">
        <property type="interactions" value="1397"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U0N6"/>
    <dbReference type="Gramene" id="CDP01694">
        <property type="protein sequence ID" value="CDP01694"/>
        <property type="gene ID" value="GSCOC_T00036830001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0N6"/>
    <dbReference type="OMA" id="LWHMLHI"/>
    <dbReference type="OrthoDB" id="767975at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U0N6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF31">
        <property type="entry name" value="PROTEIN ALTERED XYLOGLUCAN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP01694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41271" checksum="D9B64283E9E8CAEB" modified="2014-10-01" version="1">MLGAVQFGVLAACIVLFVPMGMAGWHLSRNKMLFFSGALFITLAVGVHLTPYFPSFSAFIPSSSSLPSSPTVVASSVNRDSCISSLHEIEFHNQDSRNNDSTSEKKSWKWVDSNKGVVDCEFQKLSKSDASDLLNGSWVVVAGDSQARLMVVSLLELLMGLDEIERVRGDLFKRHSDYRTTVDVIGMKLDFIWAPYVSNLTDLMVEFREKRYHPDVFVIGSGLWDMLHMNNATDYGVSVSRLKDSLMPLLPVTPEFEFEDRPVVVRSPLMFWLRMPTLINSILNTEEKRAKMTDAMWYAYDEQIYKSKLVRNFGGPLFLLDIRYLSSRCGRTCTVDGMHYDGIVYEAAVHIMLNALLIESQQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1H7</accession>
    <name>A0A068U1H7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039728001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U1H7"/>
    <dbReference type="FunCoup" id="A0A068U1H7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1H7"/>
    <dbReference type="Gramene" id="CDP02366">
        <property type="protein sequence ID" value="CDP02366"/>
        <property type="gene ID" value="GSCOC_T00039728001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1H7"/>
    <dbReference type="OMA" id="FQFNRFS"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1H7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044521">
        <property type="entry name" value="AtbZIP8/43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46324">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46324:SF3">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="180" mass="21141" checksum="93DDD8622BC0C4E4" modified="2014-10-01" version="1">MQSGDATELYYLLTSNPTQYPSHFGLNNNNMPSFNLSRISNPLCHLQINPQIQDFNPQMASFSCNSTSDEADDQQLSIINERKQRRMISNRESARRSRMRKQKHLDELWSQVVWLRNENHQLIDKLNHASECHDRVLQENTQLKEEASELRQMLTEMQLNSPYYNLRDLEDDPCKGLSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U295</accession>
    <name>A0A068U295_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00039833001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U295"/>
    <dbReference type="FunCoup" id="A0A068U295">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U295"/>
    <dbReference type="Gramene" id="CDP02452">
        <property type="protein sequence ID" value="CDP02452"/>
        <property type="gene ID" value="GSCOC_T00039833001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U295"/>
    <dbReference type="OMA" id="DPDLKCW"/>
    <dbReference type="OrthoDB" id="728902at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U295"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000694">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g50420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000285">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015">
        <property type="entry name" value="OS07G0578800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015:SF2017">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="77519" checksum="ECA0FBFA4C130567" modified="2014-10-01" version="1">MRSPNEAASIATLLIQKCSSTTSIRRARQLHALLLTSATAHLRCSYAFNNIVSMYARCGSLADSQLVFDNIPHRNIVSYNALVSSYSRTTRHASLAFRLFDQLLNENLRPNGSTFTSLLQASSTLKNVMLGSFLHAQCIKFGFMDNVRVQTSLLGLYSSCGVLELTQKVFHFMVDKDAMAWNTVIFGYLENGKMVEGLGIFSTMIRDGARPDQFTHSMVLNACGRLGDYDTGKRAHAHSLILGTCLDLPLHNALLDMYCSCGDTETAIRVFRRISNPDLVSWNTIIAGYSENGDGAKAMDMFVQLVHGFTRKPDEYTYAAVISATGAFPACNYGKPLHAQVQKAGLERSVYVGSTLISMYFSNAESESAQKIFSSVLEKDVVLWTDMVAGYSRIGDGETAVKFFHGMSQEGHEIDSYALSSGVSACADLATLRQGQMVHNLVVKKGYDTEMTVCGSLIDMYAKVGDVQAAEAIFSEVIMPDLKCWNSLLGGFSHHGKAEDAFQVFDCILKQGIKPDNVTFISVLSACSHCGLVERGKFYWNYMKVKGIKPGPKHYSCMITLFSRAGLLEEAEKLIIESPFANDYMVLWRTLLDSCVMNKNLKIGTHAAERVLSMDAEDAATNVLLAKLYAADGRWGGVAEMRRKIKIQMLEKDPGLSWTENLNDIHVFSSGDQSHPLNDEMRVEIQRLLKHSMYTEKSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3R8</accession>
    <name>A0A068U3R8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00041421001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3R8"/>
    <dbReference type="FunCoup" id="A0A068U3R8">
        <property type="interactions" value="2059"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3R8"/>
    <dbReference type="Gramene" id="CDP02977">
        <property type="protein sequence ID" value="CDP02977"/>
        <property type="gene ID" value="GSCOC_T00041421001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3R8"/>
    <dbReference type="OMA" id="QPTNGPD"/>
    <dbReference type="OrthoDB" id="20621at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3R8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37769">
        <property type="entry name" value="OS08G0243900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37769:SF1">
        <property type="entry name" value="OS08G0243900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="2">
        <location>
            <begin position="397"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="637" mass="68877" checksum="1479D15F056F6915" modified="2014-10-01" version="1">MSCLALSLQPTNGPDVLLQTREWFPPSRALMALSAFRKTRLAFSSKQQSAAVASNSDNSSADPSSLGDDPLAASSGQVIVGVESRYRVVYRLVNSIYVLGITTADETNNNVFECISIVNQAVSVVVTACRGVDVTPEKLSKKYAEIYMALDIVLRGVSSIRLAAMLATMHGDSIAKMVHSAINTENKIRGADSWVNLEVHSVEHEGGLEAFSKAVFELPQETLEAGDEVAATMAFSGGQGDEKEEGEVEEEEEEKDPFAASEKINQPASLVEGFKKDKDQSSDLTKALAGLEVTTLPPAAATESTHIGVEGFEGNYGGIEFSNDGSTLREDFEGFSDAWGGGLDASDYVESKKVKKHEGLGGLELLETSDPPVKTAAAAADGAGKNLEDVLVKKTEMKGPEMYIAEEISAEFRESLLARVGLTGVVYLRTLPPKPSDDRETEFSFKVENTGSVKRFVLQSSRVSSLGNGLFHVRTAPSGEPIPIVKYSLLPRLTPLPLRVRLVKRLSGTLLSVMIQYVSNPDLPAPLNDVTFVLKLPVDPTLLKVSPKAVLNRSEKEIKWHVPEIPLKGNPGRLRVRMPVDIGDEDDDIDFEVVCHVKFSGQGSKSLSGISLRPASEGKTDFYEVDDRFASGVYMCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U712</accession>
    <name>A0A068U712_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017671001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U712"/>
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        <property type="protein sequence ID" value="CDP04320"/>
        <property type="gene ID" value="GSCOC_T00017671001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U712"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="116" mass="12936" checksum="6B1DDB84469EC0BD" modified="2014-10-01" version="1">MQVEDMSGQATEQHCPKKGEREGSGKKANAADVQKQRNTGTWETRSETEALCANNITLSITCAARERTTKTIQVIRALRSLSTYVEKFSHKTSTNFRQQPMGKENKSKVGKGRGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7X0</accession>
    <name>A0A068U7X0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7903 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00017580001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068U7X0">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP04249">
        <property type="protein sequence ID" value="CDP04249"/>
        <property type="gene ID" value="GSCOC_T00017580001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7X0"/>
    <dbReference type="OMA" id="IWHVIAN"/>
    <dbReference type="OrthoDB" id="2014147at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7X0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057225">
        <property type="entry name" value="DUF7903"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35481">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35481:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25475">
        <property type="entry name" value="DUF7903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7903" evidence="3">
        <location>
            <begin position="66"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP04249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="427" mass="48296" checksum="8AD813CE57C45BE1" modified="2014-10-01" version="1">MAAYIPPHKRHSRGGGSSSSSAINPSPSLTPESLSPHFKRGLNFRSSFSDKKKNNRDRGKGGGGGGQKIIYDQNAVSKWFPVGLAASSGDDTDNNDTNFMSLTRLQPISVESFQRKSGEKPLSLVLNHDRVKECSEERSVFMENPWLFAAENVMQDLRSAFQRVQNEVEDNKLEEVKPTLVARVGQILFHGGQSTLPESSLRQLKRSFYTNVSASYMEYIVDEVVPKCMFDFQEEKEIYHIKLSDNMRPDSTISCKCTLAKDREKLEFYKIEWNQVRHLVVDMSCLEKDLDLRLMLCTKRIIKTLTDNEIECIKSLIGSAVLDPDVKGGLRWPLGLDSSGDRYAVVGVWHVNAKSFRNSSIRLKARHADRFDFRTSSGEVSREVAMKMKGIVSNLPEQTKQDDLLHEMLSSNLKLIWENCLCFSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8Z6</accession>
    <name>A0A068U8Z6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Subtilisin-like protease fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00018801001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8Z6"/>
    <dbReference type="STRING" id="49390.A0A068U8Z6"/>
    <dbReference type="Gramene" id="CDP04727">
        <property type="protein sequence ID" value="CDP04727"/>
        <property type="gene ID" value="GSCOC_T00018801001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8Z6"/>
    <dbReference type="OMA" id="INITRMH"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8Z6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="3">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP04727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="232" mass="25699" checksum="65B5F51A7F44A93E" modified="2014-10-01" version="1">MIAFEGTFVGLKEAPAIAFCSSRGPSLTSPRNLKPDIIDLGVSILAAWPSSVDNITKGSLHPDCLPAAVKSSIVTSADFLNHDGSLILDERMLPADLFAIGAGHVNPARAADPGLVYDIHPDNYVQYLCGLNYTDDHIMFITQARITCTYKRTVTNVDKAYSVYNSLITSIPGIDIRVYPTVLRFIRMNQKMTYQISFKRTDRFKNATYMQGPITWSSNQHSVRSPILIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U985</accession>
    <name>A0A068U985_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectinesterase</fullName>
            <ecNumber evidence="5">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00018805001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5"/>
    <dbReference type="EMBL" id="HG739097">
        <property type="protein sequence ID" value="CDP04729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U985"/>
    <dbReference type="FunCoup" id="A0A068U985">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U985"/>
    <dbReference type="Gramene" id="CDP04729">
        <property type="protein sequence ID" value="CDP04729"/>
        <property type="gene ID" value="GSCOC_T00018805001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U985"/>
    <dbReference type="OMA" id="FIHCTLE"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U985"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000029">
        <property type="entry name" value="Pectinesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000021">
        <property type="entry name" value="Probable pectinesterase/pectinesterase inhibitor 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011115630" description="pectinesterase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="17">
        <location>
            <begin position="52"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP04729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="562" mass="60248" checksum="EC1933CDA996903B" modified="2014-10-01" version="1">MAAILSLSLLSLLLFFSFSTALRHHNHRHYSPAPSHSISKPPPSSASPSVSSPNGLIHEACKASRDPPTCESSLSSSSTGSPNPTVLDTIQLAIRVSKENLRTAQSMVNDILGASAGNLNRTNAAKNCVEVLNYSDFRSDQTASALARGKIKDARAWMSAALVYQYDCWSALKYVNGTSKVNETMAFLNGLLGLSSNALGMMVNYDNLGEDTGSWGPPKTERDGVWEGVGGSGSGSGLEFHGGVPTGLKPDVTVCKEGGCNYGSVQAAVNAGPDNAVDRRFVIWIKAGVYEETVRVPLEKKNVVFLGDGMGKTVITGSMNVGQPGVTTYDSATVGVVGDGFMASGLTIQNTAGPNAHQAVAFRSDSDLSVIENCEFLGNQDTLYAHSLRQYYKSCRIQGNVDFVFGNSAAFFQGCLVLVAPRQVKPEKGENNAVTAHGRIDPAQSAGFVFLGCIVNGTEEYMSLYYSKPSVHRNYLGRPWKEYSRTVFIQCTLEALITPDGWMPWSGDFALKTLYYGEFGNTGAGADTSKRVPWSSQIPAKHVSSYSVPNFIQGDQWIPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9M2</accession>
    <name>A0A068U9M2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7725 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00019902001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9M2"/>
    <dbReference type="FunCoup" id="A0A068U9M2">
        <property type="interactions" value="2472"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U9M2"/>
    <dbReference type="Gramene" id="CDP05002">
        <property type="protein sequence ID" value="CDP05002"/>
        <property type="gene ID" value="GSCOC_T00019902001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9M2"/>
    <dbReference type="OMA" id="QATHAEH"/>
    <dbReference type="OrthoDB" id="2020644at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U9M2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056142">
        <property type="entry name" value="DUF7725"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35766">
        <property type="entry name" value="OS08G0543600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35766:SF1">
        <property type="entry name" value="OS08G0543600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24851">
        <property type="entry name" value="DUF7725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7725" evidence="3">
        <location>
            <begin position="621"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="869" mass="95912" checksum="1401978D2719992E" modified="2014-10-01" version="1">MEAAAGVAAARGVSLSVPSSQPSRKEWRVVSETSVRSSSNEELERSKLGQSDERLIYEVQQGREPADVDFCSITIDGSLDNDILQQRLHSVVKQREELQQMETELRAQLIARGEIMEMRSTYDAHIKEHENAKIKLQEQLREKEQRMLELERKMEDKERELHAIRLDNEAAWAKEDLLREQSKELQTYRRERDNTEAERAQHIKQIHELQEHFQEKDRQLMELQEQNRIAQENILFKDEQLREAQAWITRVQEMDALQSTTNHSLQAELRERTEQYNQLWLGCQRQFGEMERLHLHIQQLQHELADARERSNTYSDASHVSQTNPRDVSQIGKSNSGHLDMSGSGSPGESSSLPNGNADNASFVSVGNASVQADHAHGVPIAPSSLLGMPTYLPHGQMTAVHPFVVHQQGVPHSVPSHVGHFHSVPAVSSLQQWQNQQAVSEGAATHDQHSLQTEPNMLRSDSNYNYESSVNGQVLHSGYMNVNISQGMEPHSVVSSSNVEGQPVESIDTSYLSGAQPQQSLQQISSQFHDALRLDSLAHVNDTKEKNVNSLSNSPMEVQGLMMEKSGSISNESSSEEANHAANLSESTMDTAAEVILSESFAAAGQKNTGIGGKLSEANLLDERSLLACIVRTIPPGSGGRIRITTTLPNRLGKMIAPLHWHDYKKKYGKLDEFVSSHPELFVIDGDYIQLREGAQEIIAATAAVAKVAAAAAAAVTSSYSSLVPSVAVTPMAQSHRLKKAPSMEFTSGKSDRSIFKEYAVSRPSNAIDNSSQLSAMKNQHPNGVSFSNSEGVSNVKILSKPKDHTGMNSSESRHGQSTLLTYGNGTNSEKNDFGSSQNKGSTQWKTSGSVVGNQQGRVVGAAASPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U9V5</accession>
    <name>A0A068U9V5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00017768001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U9V5"/>
    <dbReference type="Gramene" id="CDP04393">
        <property type="protein sequence ID" value="CDP04393"/>
        <property type="gene ID" value="GSCOC_T00017768001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U9V5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP04393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="70" mass="7991" checksum="68A62C544C91B8CA" modified="2014-10-01" version="1">MWRRNAAILPPAKLVDDPVRRRRLASIFKGQRQAPHMTLIVRQRRMPVAPITTQASITLRTGAWTPPSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBW3</accession>
    <name>A0A068UBW3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00020849001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739101">
        <property type="protein sequence ID" value="CDP05664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBW3"/>
    <dbReference type="FunCoup" id="A0A068UBW3">
        <property type="interactions" value="974"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UBW3"/>
    <dbReference type="Gramene" id="CDP05664">
        <property type="protein sequence ID" value="CDP05664"/>
        <property type="gene ID" value="GSCOC_T00020849001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBW3"/>
    <dbReference type="OMA" id="SKKSLYM"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UBW3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990714">
        <property type="term" value="F:hydroxyproline O-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010405">
        <property type="term" value="P:arabinogalactan protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000005">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000071">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase GALT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000147">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase GALT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF212">
        <property type="entry name" value="HYDROXYPROLINE O-GALACTOSYLTRANSFERASE GALT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="16">
        <location>
            <begin position="174"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP05664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="668" mass="75676" checksum="7CC8D02B19731EBA" modified="2014-10-01" version="1">MKRIRSESQSGRRFKLSHLLMGLAALYLIVICLKFPKFLESAAVLSNNGNDVGKEGLRDGFHRILQNNVNQNAPPMPREEALEEKKGGSTPVNPLSLHYGRIAAAILRRRNRTSDFSVVEKMADEAWSLGTKAWEEVGKHDGKDIEMNATLEGKPESCPSWVSVNAEELARGDNLMFLPCGLAAGSSITVIGTPRVAHQEYVPQLARLRAGDALVLVSQFMVELQGLKAVVGEDPPKILHLNPRLRGDWSHRPVIEHNTCYRMHWGSAQRCDGLPSKSDDEMLVDGFLKCEKWMRNEIVDSKESKISKESKIFSWFERFIGRAKVPEVTWPFPFMEGRMFVLTIRAGVEGYHIIVGGRHVTSFPYRTGFTLEDATGLAIKGDVDVHSVHATSLPTSHPSFSPQRVLSFSEQWKSHPLPHHGIQLFIGVLSATNHFAERMAVRKTWMQSLAVRSSNVVVRFFVALNPRKEVNAVLKKEAAYFGDIVIIPFMDRYELVVLKTIAICEYGVQNVTAAYIMKVDDDTFVRVDNVLEQIEGFSPKRSLYMGNLNLLHRPLRTGKWAVSFKEWPEAIYPPYANGPGYIISSDIANYIVSQHLKRSLRLFKMEDVSMGMWVEQFNSSKPVQYSHSWKFCQYGCTEDYYTAHYQSPRQMLCLWANLIKGRARCCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCE3</accession>
    <name>A0A068UCE3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00020299001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCE3"/>
    <dbReference type="FunCoup" id="A0A068UCE3">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP05303">
        <property type="protein sequence ID" value="CDP05303"/>
        <property type="gene ID" value="GSCOC_T00020299001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCE3"/>
    <dbReference type="OMA" id="CTLELPN"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCE3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000371">
        <property type="entry name" value="Protein NSP-INTERACTING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000379">
        <property type="entry name" value="Protein NSP-INTERACTING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000485">
        <property type="entry name" value="Protein NSP-INTERACTING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF65">
        <property type="entry name" value="OS01G0577600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="377"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP05303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="649" mass="70933" checksum="E9B0235485ACBA3F" modified="2014-10-01" version="1">MSLKASLDPESRLLVSWTGSGDPCGGSFVGVACNRRGQVANISLQGKGLSGKLCPAVAELRHLTGLYLHYNALYGEIPREISSLSELTDLYLNVNNLSGEIPPELGNMDSLQVLQLCYNQFTGSIPTQLGALKKLNVLALQFNELTGAIPASLGDLGSLMRLDLSFNRLFGSIPTKLADAPILEVLDVRNNSLSGNVPNALKRLIGGFQYENNPGLCGAGFSSLRACTASDRPNPSRPEPYGGGPTGLSTRDIPETANLRLNCSETHCSKSSKALQASVIVGVLVVCIIVLVIGILSFSHYHRKQKLENASDAQDSRLPTDHAKGAQRKNGSPLISLEYPSGWDPLAEGRHFGDVSQEFMQSFRFNLEEVESATRYFAEKNLLSKSYFSATYRGSLRDGSVVAVKSISKTCCKSEELEFLKGLNILTSLRHENVVRLRGFCCSKDRKECFLIYDFVQNGNLLQYFDVVDGSDHVLDWSTRVSIINGIARGIEYLHGYKVNKPAIVHQNISAASVLIDQRNRPLLSDSGLHKLLTNDTVFSTLKDSAAMGYLAPEYSTTGRFTEKSDIYAFGVLLFQILSGVRKVTSSMQAAADLGKTQDFMDRNLHGKFSEPEAIRVGKVALWCIHESPEERPGIETVLQELGNCTNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCG0</accession>
    <name>A0A068UCG0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Monocopper oxidase-like protein SKS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00020321001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCG0"/>
    <dbReference type="FunCoup" id="A0A068UCG0">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UCG0"/>
    <dbReference type="Gramene" id="CDP05323">
        <property type="protein sequence ID" value="CDP05323"/>
        <property type="gene ID" value="GSCOC_T00020321001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCG0"/>
    <dbReference type="OMA" id="ITWPGIQ"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCG0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13846">
        <property type="entry name" value="CuRO_1_AAO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000012">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000016">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000023">
        <property type="entry name" value="Monocopper oxidase-like protein SKU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034273">
        <property type="entry name" value="CuRO_1_AAO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF270">
        <property type="entry name" value="MONOCOPPER OXIDASE-LIKE PROTEIN SKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654779" description="Monocopper oxidase-like protein SKS1" evidence="13">
        <location>
            <begin position="25"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="161"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="399"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP05323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65912" checksum="2FD7F45352D0F1DA" modified="2014-10-01" version="1">MAVLGTTAAFLLIHIAILFSPSFAADPFAFFDFEVSYTTASPLGVPQQVIAVNNKFPGPVINVTTNYNVVLNVRNKLDEDLLITWPGIQMRRSSWQDGVLGTNCPIPSKWNWTYQFQVKDQIGSFFYYPSLNLQRAAGGFGPFIVTNRDIIPIPFAMPDGDIVLMIGDWYTQNHTALREALDNGKQLGMPDGVIINGKGPYRYNNTLVPDGIDYETINVDPGKTYRVRVHNVGASTCLNFRIQSHNLLLAETEGYYTSQQNYTSMDIHVGQSFSFLVTMDQNASSDYYIVASARFVNQTVWQRVTGVAILHYSNSKGKASGPLPDPPNDVYDSSYALNQAMSIRQNVTASGARPNPQGSFHYGQINVTDTYILRSVPPVTIEGKLRATYNGISFVKPETPFRLADAFNVKGAYKLDFPSQPLDRPPKMDRSIINATYKGFIEIILQNNDTVVQSFHLDGYSFFVVGMGSGNWTENSRGSYNRWDAISRSTVQVLAGGWTAVLVSLDNVGIWNLRSENLDRWYLGQETYMRIVNPEDAGNKTELPVPDNVLYCGALAKFQKPQKASSATTIHVGSKAYLTLLVVFFAMIYIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDR1</accession>
    <name>A0A068UDR1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023140001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739105">
        <property type="protein sequence ID" value="CDP06339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDR1"/>
    <dbReference type="Gramene" id="CDP06339">
        <property type="protein sequence ID" value="CDP06339"/>
        <property type="gene ID" value="GSCOC_T00023140001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDR1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="94" mass="10588" checksum="0392E60523D1F9F6" modified="2014-10-01" version="1">MARRVQLRCPLLFSVSNPCVSCCVLCRIDGLVSQSGRIQCLCFRLTSLSLFFLTILLCFSSYYAKSIDPRSLAISGLQWFRSAMHPLSLAFFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFL4</accession>
    <name>A0A068UFL4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macrophage migration inhibitory factor homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023273001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFL4"/>
    <dbReference type="STRING" id="49390.A0A068UFL4"/>
    <dbReference type="Gramene" id="CDP06423">
        <property type="protein sequence ID" value="CDP06423"/>
        <property type="gene ID" value="GSCOC_T00023273001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFL4"/>
    <dbReference type="OMA" id="MPCLDIS"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFL4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.429.10:FF:000004">
        <property type="entry name" value="Tautomerase/MIF superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF25">
        <property type="entry name" value="LS1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12039" checksum="D6C5BA0F28F46A99" modified="2014-10-01" version="1">MPCLDISTNVNLNGVDLDSVFSEATKTVAAIMGKPETFVMVLLKGSVPISFGGNKEPAALGEIISMGGINREVKRKLIAAIGTILETKLSIPRTRFVLKVYDTTMGRNQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGB7</accession>
    <name>A0A068UGB7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KIB1-4 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00024552001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGB7"/>
    <dbReference type="STRING" id="49390.A0A068UGB7"/>
    <dbReference type="Gramene" id="CDP07322">
        <property type="protein sequence ID" value="CDP07322"/>
        <property type="gene ID" value="GSCOC_T00024552001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGB7"/>
    <dbReference type="OMA" id="IDYLRFR"/>
    <dbReference type="OrthoDB" id="600964at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UGB7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050942">
        <property type="entry name" value="F-box_BR-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259:SF114">
        <property type="entry name" value="OS06G0707300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44259">
        <property type="entry name" value="OS07G0183000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIB1-4 beta-propeller" evidence="1">
        <location>
            <begin position="69"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="45399" checksum="49A60B5A4BC9A64A" modified="2014-10-01" version="1">MSSVDWSSLPPELIQKISIDLKIYADYIRFRAVCTTWRTSTPTTPTHLPCQLPWLMLPQSRSSSHRRAFFNLADNKCHVLGLPEASHRRRHSGSSHGWLVMLDEYPPIFLVNPLTRAKIDLPPLSTFPCVVGFDVFNVGREYVLQSSDDESHVNYVSRFYTCGLKEMRDSFVKKIVLSNSPSGGSKFLALAIINKTGDLAYWKDGLNSWGLIEGARSFCEDVIYFNGLFYAADKNGSIAVCDVGGDSPRVEFIRTPGLSDGDMQYLVIANGELLLVTRYLELASDLGQLQIGIGTYETREFRVFKLDLSGSKWERVMSLGDTMLFLGENSSLALVASDFPECRGNRIYFTDDFSELDYSGFPGNHDLGIFDLEDGTIEQLPCHPRTSHSHLQWPPPIWITPNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UGS4</accession>
    <name>A0A068UGS4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00023851001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UGS4"/>
    <dbReference type="Gramene" id="CDP06838">
        <property type="protein sequence ID" value="CDP06838"/>
        <property type="gene ID" value="GSCOC_T00023851001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UGS4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP06838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="51" mass="5524" checksum="14EE960EBCABD7A1" modified="2014-10-01" version="1">MTADKRKKPSCDSPPVSCTSDCSSHSSTTSNNYIDCLSTYIEASQFAMQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UI51</accession>
    <name>A0A068UI51_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00025412001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739112">
        <property type="protein sequence ID" value="CDP07909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UI51"/>
    <dbReference type="FunCoup" id="A0A068UI51">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UI51"/>
    <dbReference type="Gramene" id="CDP07909">
        <property type="protein sequence ID" value="CDP07909"/>
        <property type="gene ID" value="GSCOC_T00025412001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UI51"/>
    <dbReference type="OMA" id="ETREWND"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UI51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000087">
        <property type="entry name" value="Kelch repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053256">
        <property type="entry name" value="Kelch_repeat-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46773">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46773:SF5">
        <property type="entry name" value="OS04G0487100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP07909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48234" checksum="9B9F31C220198D71" modified="2014-10-01" version="1">MGRPMAAIAKQHKTTAAKKLLLPCIIGLLGFALIADLLWAASSPSPASSSSSSAHFIVISHSPFPNHTHSAPAPFKDKDAANKHVKTNQRLLSATFSDLPAPLLEWEKMAPAPVPRLDGAAIQIGHLLYVFAGYGTIDYVHSHVDIYNFTNNTWGGRFDMPKEMAHSHLGMVTDGRYIYVVTGQYGPQCRGPTARTFVLDTQTKQWSNMPPLPLPRYAPATQLWRERLHVMGGSKENRHTPGLEHWSIAVKDGKALEEEWRTEVPIPRGGPHRACVVVDDQLYVIGGQEGDFMAKPGSPIFKCSRRNEVVYGDVYMLDDDMKWKVLPPMPKPDSHIEFAWKIVNNSIIIVGGTTEKHPETKKMTLVGEVFQFQLDTLKWSVVGKLPYRVKTTLVGFWNGWLYFTSGQRDRGPDDPAPRKVIGEMWRTRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIK2</accession>
    <name>A0A068UIK2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00026833001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIK2"/>
    <dbReference type="Gramene" id="CDP08107">
        <property type="protein sequence ID" value="CDP08107"/>
        <property type="gene ID" value="GSCOC_T00026833001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIK2"/>
    <dbReference type="OMA" id="EMDINGM"/>
    <dbReference type="OrthoDB" id="1896560at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIK2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="138"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="409"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="500"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP08107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="80728" checksum="E056ED45C26DA5F1" modified="2014-10-01" version="1">MADVLLNVVTEGVLNKLISLVAEEINIVWCVKEDLESLARNLEMIQALLVDAECNHTSKDAIDIWLRRLQDVSSKADNLLDEFAYEVLRNNIEKVYQEAERIGLGPVEIVSMSNNPRSDQSSTTDPFVDDSSIVGKSEEVNKVVNLLTSSEKDGNNLSVIGIVGMAGLGKTTIAQLVYKNEKVLRHFDHKLWIHVSEDFNVERLLNKMVESLTATNPNLTVGEAIVGKLNEVLKTKRFLLVLDDVWNEDAEKWDRMRKCLHGIGGSDESRIIVTTRNETVVSIMQPSFPCQLGTLSDGDSWELFEKIAFGHGCAAVKTPELINIGRKIVAKCGGVPLAVNAIGGLLWYKKDEREWSKIENSETWATMEEAGRRVRSAIKLSYDHLPSLSLKQCLSYCTIIGKGGVAAVEIMIQLWMAQGLLNPSKGSLLEMEDVGSNYTSILFRTSLLQVFEKDGFGRTMYFTIHDLVFDFVEEAAKDLLKPRTLILSDGLAHDLPIVRKSLRVLVLEDENVKELPTTIGKLRCLRYLDISRTSITELPNPITQLYNLQTVKLSNLQQLPKNFGNLANLRHLYIGKDGMINGKPCLLPDIGQLSSLQTLPFFYVSRDKGCQIDQSGHLHNLRGDVKIFDLQNVSNQEEALINLDSLELHWDTRTRDGSTDEDVLKGLEPHPNLKGFTMKNFMGRSLPSWMLTTSQPLVFRNLEKIVLRNFNKCQQIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UK55</accession>
    <name>A0A068UK55_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00028054001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UK55"/>
    <dbReference type="FunCoup" id="A0A068UK55">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UK55"/>
    <dbReference type="Gramene" id="CDP08920">
        <property type="protein sequence ID" value="CDP08920"/>
        <property type="gene ID" value="GSCOC_T00028054001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UK55"/>
    <dbReference type="OMA" id="DKPMHIG"/>
    <dbReference type="OrthoDB" id="2019862at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UK55"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd02245">
        <property type="entry name" value="cupin_7S_vicilin-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02244">
        <property type="entry name" value="cupin_7S_vicilin-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050253">
        <property type="entry name" value="Seed_Storage-Functional"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189">
        <property type="entry name" value="OS03G0336100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189:SF2">
        <property type="entry name" value="RMLC-LIKE CUPINS SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658034" description="Cupin type-1 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="3">
        <location>
            <begin position="58"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="3">
        <location>
            <begin position="300"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="501" mass="55637" checksum="71317021640662A6" modified="2014-10-01" version="1">MGKISAVFLALLVVCFTLVATVGGFYNQDEGGAGIGGGGKGGEREEGGGEGVGGNSRFLLRESLDVVRTDAGHMRVIRNGGHRLWRSPMQMGLITMEPNSLFIPQYLDSNLILFVRRGEARIGHVYKDDFAERHLKTGDLYTIASGSAFYLVNAAEGQKLYIICSIETSENYGWHWHQHGFRSFFVGGGTNPTSILSGFDPLTMSTAFNVSVDELRDFTTRQHLGPIVYLSDSRAPSMWSKFLDLKEHQRLAHLKRVVHAEEEANQDEEQPTWSFRKLLISIFGEEKNRDDDDTRGPEACNIYERKADFKNDYGWSKAVDENDYSPLRHSDIGVYLVNLTAGSMMAPHVNPRAVEYGIVLRGTGRIQIVFPNGSLAMDAQVKEGDAFWIPRYFPFCQIASRAGPFEFFGFTTSSRDNRPQFLVGANSLLDNMRGPELAAAFGVDEERLGEILDAQRESTILPSSPVTPSGEGEPTKPSSREERAVPKMIRSFGSDMIMGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKQ7</accession>
    <name>A0A068UKQ7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00028022001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG739119">
        <property type="protein sequence ID" value="CDP08892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKQ7"/>
    <dbReference type="FunCoup" id="A0A068UKQ7">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UKQ7"/>
    <dbReference type="Gramene" id="CDP08892">
        <property type="protein sequence ID" value="CDP08892"/>
        <property type="gene ID" value="GSCOC_T00028022001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKQ7"/>
    <dbReference type="OMA" id="THEHMRK"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.100:FF:000001">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000265">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF27">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="9">
        <location>
            <begin position="99"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="353" mass="39390" checksum="979EE6EEF9748FFE" modified="2014-10-01" version="1">MHPLVLHSLPPAPIDSSFPPTPKPYSTLSPLPHNSFATTIRELKTAKLHGFAASASPSNPKTKTQKQDDDYHTTLKALNSKGRFPRRSLGQHYMLNGSINEQLVGAADVKEGDVVLEIGPGTGSLTNVLVNVGAAVLAIEKDPYMAALVRERFANTNRVKVLQEDFTRCHIRSHMSLIMEGRSFVESQRAKVVANIPFNISTDVVKQLLPMGDMFSEVVLLLQEEAALRLVDPSLRSSEYRPINIFVNFYSDPEYKFKVPRTNFFPQPKATVVAFRLKQALDYPRVSSTKSFFSMVNSAFNGKRKMLRKTLQHICPPTEIEAALSEVGFQTTSRPEELALEDFVKLHNLISKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL62</accession>
    <name>A0A068UL62_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00027158001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL62"/>
    <dbReference type="Gramene" id="CDP08353">
        <property type="protein sequence ID" value="CDP08353"/>
        <property type="gene ID" value="GSCOC_T00027158001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP08353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="84" mass="9124" checksum="F1B67A683B9DD25C" modified="2014-10-01" version="1">MAVAHLLLGFTVIAVVLLIEAAVTYFATETVLSLQQKSTKACKTRVFKFGAGLSVTQLTAQIYQLMILTVSTKGFDSPEARCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULH7</accession>
    <name>A0A068ULH7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00028595001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739121">
        <property type="protein sequence ID" value="CDP09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULH7"/>
    <dbReference type="STRING" id="49390.A0A068ULH7"/>
    <dbReference type="Gramene" id="CDP09296">
        <property type="protein sequence ID" value="CDP09296"/>
        <property type="gene ID" value="GSCOC_T00028595001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULH7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULH7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="272" mass="30066" checksum="334C21140E2386EB" modified="2014-10-01" version="1">MAPEVYDEKYDELVDIYTFRMCMLELIICDYPYSECTNVAQIYKKVTKGVKPLALGNVKDPQVKGFIEKCLLPAAQRPSAAQFLKDPFLSSPESLKGDKCESGVRPSGVLPESNNIPQPDSQVSTSNDGSSYNKASTSSKASAESIIRPGPISILESLRSTEQIQLRLRGKRIDQKTVLFNLRIADLHGPVANCFEFLFDLKSDDALKIASEMVQGKDLTYGDVPVAVELMDSMLLELEPTWKPCNAYYSANNVASECRELGSNWQLGAVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULL7</accession>
    <name>A0A068ULL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00027445001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULL7"/>
    <dbReference type="FunCoup" id="A0A068ULL7">
        <property type="interactions" value="2241"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068ULL7"/>
    <dbReference type="Gramene" id="CDP08513">
        <property type="protein sequence ID" value="CDP08513"/>
        <property type="gene ID" value="GSCOC_T00027445001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULL7"/>
    <dbReference type="OMA" id="DTQGNTC"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="PhylomeDB" id="A0A068ULL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000047">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="183" mass="20127" checksum="2D6BA1F8D6D49461" modified="2014-10-01" version="1">MTTTMNSESSNNSNTPAAGPVMTSSKQPVQSAKNVDTQSVLKRLQSELMALMMSGDSGISAFPEEDNIFCWKGTITGSKDTVFEGTEYKLSLSFPTDYPFKAPKVKFETGCFHPNVDVYGNLCLDILQDKWSSAYDVRTILLSIQSLLGEPNTSSPLNNQAAALWGNQAEYRKMVEKLYKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068ULQ2</accession>
    <name>A0A068ULQ2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028738001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068ULQ2"/>
    <dbReference type="Gramene" id="CDP09391">
        <property type="protein sequence ID" value="CDP09391"/>
        <property type="gene ID" value="GSCOC_T00028738001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068ULQ2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="63" mass="7250" checksum="E1FEA97DD864D1A6" modified="2014-10-01" version="1">MLWILVVWRMVTRSPAGSVSALLLLYLRRNLSMKLPTCLTRLKCSSAFFVNWSLSKQDIISAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMF8</accession>
    <name>A0A068UMF8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00028808001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739122">
        <property type="protein sequence ID" value="CDP09439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMF8"/>
    <dbReference type="FunCoup" id="A0A068UMF8">
        <property type="interactions" value="914"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09439">
        <property type="protein sequence ID" value="CDP09439"/>
        <property type="gene ID" value="GSCOC_T00028808001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMF8"/>
    <dbReference type="OMA" id="MQMHFEV"/>
    <dbReference type="OrthoDB" id="419333at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMF8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018881">
        <property type="entry name" value="C2orf69_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296">
        <property type="entry name" value="UPF0565 PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10561">
        <property type="entry name" value="C2orf69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP09439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36352" checksum="07F156C9B6F0EDB1" modified="2014-10-01" version="1">MDRWTGILKVPLHPNSSSFYRVAASLCIFSSTKTLAVPSANAIFFNGDQVEGTGNFVIERLSDVQKIAEILVSKFGSTINAWVIEANTFNGPFAVYKDFIPTVNLDGEPQSYNATGLPASSSIVLLLSNCLKEAKSSMLGGQPYQAAPSASCSFKPKTLFLGFSKGGTVLNQLLTELGSMEVQPTSSDSRAKKTMMDEGSGMWEEHQIIPTSKEELLNSIAEIHYVDVGLNSEGAYLTNQDVIEGISDRLTRRAFGMRIILHGTPRQWSDRWRTWICKEKNEFFRLLKLAARKNMGKLMLRERFYFADRPPSLQMHFEIIENLDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UNU3</accession>
    <name>A0A068UNU3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030428001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739125">
        <property type="protein sequence ID" value="CDP09929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UNU3"/>
    <dbReference type="FunCoup" id="A0A068UNU3">
        <property type="interactions" value="1376"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UNU3"/>
    <dbReference type="Gramene" id="CDP09929">
        <property type="protein sequence ID" value="CDP09929"/>
        <property type="gene ID" value="GSCOC_T00030428001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UNU3"/>
    <dbReference type="OMA" id="DSYMGNV"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UNU3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010540">
        <property type="term" value="P:basipetal auxin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048527">
        <property type="term" value="P:lateral root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048573">
        <property type="term" value="P:photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010167">
        <property type="term" value="P:response to nitrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="607" mass="67353" checksum="545D23B305259BEE" modified="2014-10-01" version="1">MALPQSYEEAKTIPDAWDYKGGQAQRSTTGGWAAAAMILGVEACERLTTLGIAVNLVTYLTGTMHLGNATSANTVTNFLGTSFMLCLLGGFIADTYLGRYLTIAIFAAVQATGVALLTISTTIPSLRPPKCAQGSRSCVQASGNQLLVLYAALYLTALGTGGLKSSVSGFGSDQFDDSDEKERKKMIKFFNWFFFFISVGSLCAVTILVYIQDNVGRRWGYGICACAIVVGLLVFLAGTRRYRFKKLVGSPLTQIASVIVAAWRKRHLDLPSDSSLLFNVDDIPIEGRKKKQRLPHSKQFRFLDKAAIKDHEMTMNKWCLSTLTDVEEVKLVIRMLPIWATTIMFWSVHAQMTTFSVSQASTMHRKINNFEIPSAAMTGFFVGSTLLTVVIYDRIIMPICKRLLKNPYGLTPLQRIGIGLFLSIVGMVAAAAVEIKRLHVAKSHGLANNPVTPVPMTVFWLIPQFAIVGAGEAFIYVGQLDFFLRECPKGMKTISTGLFLSTLSLGFFFSSVLVTIVHKVTGNRKPWLADNLNQGKLNDFYWLLGILSALNLMFFLICAKWYVYKERRLADVGIELEESFFFFFFFCLCKISKECKRTTPSCTFIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP07</accession>
    <name>A0A068UP07_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00030898001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer (dimer of homotrimers).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP07"/>
    <dbReference type="FunCoup" id="A0A068UP07">
        <property type="interactions" value="1849"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UP07"/>
    <dbReference type="Gramene" id="CDP10235">
        <property type="protein sequence ID" value="CDP10235"/>
        <property type="gene ID" value="GSCOC_T00030898001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP07"/>
    <dbReference type="OMA" id="DSPANQM"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UP07"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000011">
        <property type="entry name" value="Leucine aminopeptidase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000033">
        <property type="entry name" value="M17 leucyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002076">
        <property type="entry name" value="PRK00913.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="12">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="526" mass="54821" checksum="54D6F671A7DC47D7" modified="2014-10-01" version="1">MAHSIAHATLGLTQPNQIVPPKISFAAKEIDLVEWKGDILAIGVTEKDIAKDESSKFQNPILQKLDSKLGGLLSEASSEEDFTGKAGQSTILRVPGLGTKRVGLVGLGQAASTTAAYRSLGETIAAAAKSAQASNVAIALASSETLSADSRLTTVSAIATGTVLGTYEDSRFKSESKKPTLTSVDILGLGTGPEIEKKLKFAESVSSAVIFGINLVNAPANVLTPAVLAEEAKRIASLYSDVLTTTILNVEQCKELKMGSYLGVAAASANPPHFIHIVYKPLGGSVKTKLALVGKGLTFDSGGYNIKTGPGCSIELMKFDMGGSAAVLGAAKALGQIKPAGVEVHFIVAACENMISGTGMRPGDIVTASNGKTIEVNNTDAEGRLTLADALVYACNQGVEKIVDLATLTGACIIALGSSIAGVYTPSDDLAKEVLEASEVAGEKLWRMPLEESYWESMKSGVADMVNTGGRPGGSITAALFLKQFVDEKVQWMHIDMAGPVWNEKKKGATGFGISTLVEWVLKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UP85</accession>
    <name>A0A068UP85_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00030864001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UP85"/>
    <dbReference type="STRING" id="49390.A0A068UP85"/>
    <dbReference type="Gramene" id="CDP10211">
        <property type="protein sequence ID" value="CDP10211"/>
        <property type="gene ID" value="GSCOC_T00030864001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UP85"/>
    <dbReference type="OMA" id="LNDMVHW"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UP85"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000027">
        <property type="entry name" value="Putative CCR4-associated factor 1 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="274" mass="31355" checksum="FA0BA2C4EC51C3AD" modified="2014-10-01" version="1">MTVLPSHDSIHIREVWNDNLEDEFALIREIVDDYPYIAMDTEFPGVVLRPLGDYKNFTDFHFKTLKANVDLLKLIQLGLTFSDEKGNLPTCGTGKYCVWQFNFREFNPNEDVYAHDSIELLRRSGFDFKKNVDNGVDAYRFSELLMSSGIVLNDSVSWVAFHSGYDFGYLLKILTCQNLPETQEGFFKLIKMYFPTVYDIKHMMRFCNHLHGGLNKLAELLEVERVGICHQAGSDSLLTCCTFMKLKESFFHGTTEKYAGVLYGLGVDNGPNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UPH3</accession>
    <name>A0A068UPH3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00031172001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium sensor.</text>
    </comment>
    <dbReference type="EMBL" id="HG739129">
        <property type="protein sequence ID" value="CDP10445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UPH3"/>
    <dbReference type="STRING" id="49390.A0A068UPH3"/>
    <dbReference type="Gramene" id="CDP10445">
        <property type="protein sequence ID" value="CDP10445"/>
        <property type="gene ID" value="GSCOC_T00031172001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UPH3"/>
    <dbReference type="OMA" id="LLTSECM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UPH3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000089">
        <property type="entry name" value="calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655098" description="EF-hand domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP10445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="236" mass="26637" checksum="C3CCC5644150769A" modified="2014-10-01" version="1">MWTAILLLVLLFVAGLISTNFNRKKFLAWFQSYCAKIRNPSSHAANSFDFLETKSGKKVDKRRSADNKKVQLGSIFATFDKNNDGYITKQELKDSLNNIGMGMTESDIADMVRRVDSNGDGLIDLEEFCESFDSLIGRGEMNEEEQERDVTDDEDEEVSREDELKEAFAVFDGNKDGLITVEELGLVLSSLGFKEGKKLEDCIEMIRKVDVDGDGMVNFDEFKRMMKAGHRLLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR23</accession>
    <name>A0A068UR23_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00031531001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="HG739130">
        <property type="protein sequence ID" value="CDP10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR23"/>
    <dbReference type="FunCoup" id="A0A068UR23">
        <property type="interactions" value="3308"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UR23"/>
    <dbReference type="Gramene" id="CDP10727">
        <property type="protein sequence ID" value="CDP10727"/>
        <property type="gene ID" value="GSCOC_T00031531001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR23"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR23"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000002">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="69"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="242"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="432" mass="50032" checksum="9218C19673B1B5DB" modified="2014-10-01" version="1">MDDNDKPTENPKPTSDANITPENESEISMDSLARKVQESLSLAKRHKFWETQPVGQFKDFGDRSLPEGPIEAPTPLSEVKQEPYNLPSQYEWITCDMDSEEMCNEVYNLLTSNYVEDDENMFRFNYSKEFLQWALRPPGYFRSWHIGVRAKSSKKMVAFITGVPARIRVRETIVNMAEINFLCVHKKLRSKRLAPVMIKEVTRRVHLENSWQAAYTAGVVIPTPITTCQYWHRSLNPKKLIDVGFSRLGARMTMSRTIKLYKLPDQTATPGFRKMEPHDVPAVTRLLRNYLRQFVLSPDFDENDVEHWLLPKENVVDSFLVESPETHEITDFCSFYTLPSSILGSQNYTALKAAYSYYNVSTKTPLTQLMNDALIVAKRKDFDVFNALDVMHNETFLKELKFGPGDGKLHYYLYNYRIRRVLRPSELGLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UR53</accession>
    <name>A0A068UR53_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00030699001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739127">
        <property type="protein sequence ID" value="CDP10093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UR53"/>
    <dbReference type="FunCoup" id="A0A068UR53">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UR53"/>
    <dbReference type="Gramene" id="CDP10093">
        <property type="protein sequence ID" value="CDP10093"/>
        <property type="gene ID" value="GSCOC_T00030699001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UR53"/>
    <dbReference type="OMA" id="HPQQMAS"/>
    <dbReference type="OrthoDB" id="2019494at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UR53"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000021">
        <property type="entry name" value="Transcription factor bHLH130 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF125">
        <property type="entry name" value="OS08G0506700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP10093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="421" mass="46102" checksum="404A59D9121A57BE" modified="2014-10-01" version="1">MYGDSQALSSDDSSIFHSSWDAKEALFAQSRELFMDSVSASSTNYSSLEFNNQYTGANQNSSGLLRFRSAPSSLLESLSAADKIVENSVENRGLTSRFNSSCEAQSNQVSHSSSTKGYTLKSQLPPQYPRASRGRLAQLGSVNGVYRVPGSMAMDHQRQPKMSPTLTRQNSSPAELFSHLTAQSGYATMRGVGNYRLTNGASGDLSPSSNRFKGPMSFSSGSPTTLGMLSRISEVENETGGADGSNDDKLGNTNGDTQLYGSGFSFGSWNNSPKFAENLTGLKREIDSDQNLFSDSQGGEPRNRPNILSHHLSLPNTAELAAMDKLMQFQDTVPCKIRAKRGCATHPRSIAERVRRTRISERMRKLQDLVPNMDKQTSTADMLDLAVEYIKDLQKQYKTLSDIRANCKCSAMQKPVPDQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URR4</accession>
    <name>A0A068URR4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSCOC_T00032968001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URR4"/>
    <dbReference type="FunCoup" id="A0A068URR4">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068URR4"/>
    <dbReference type="Gramene" id="CDP11007">
        <property type="protein sequence ID" value="CDP11007"/>
        <property type="gene ID" value="GSCOC_T00032968001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URR4"/>
    <dbReference type="OMA" id="SHDICRA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URR4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000044">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDP11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="63922" checksum="838C026488E3F4EF" modified="2014-10-01" version="1">MNFNLNSMNSTYSSSFVAGNFARKFLSGGLFFVMPAEVQMLELLLAVFVFIVIHSLRQKKRQGLPNWPFVGMLPSLILGLQGDMYEWISGVVCRQNGTFIFKGPWGTNLNCVVTSDPRNLEYLLKTKFSNFPKGEYFRNTVRDLLGDGIFSADDEIWQRQRKTASLEFHSTKFRSMTTESLLELVHSRLLPVLEESVKKSVPVDLQDILLRLTFDNVCMIAFGIDPGCLRPGLPEIPFARAFEDATEATLFRFVTPTLTWRALRSLNIGTEKKLNDSIREVDKFAEEVIQTRKKELSLPTESEKQRSDLLTVFMRLKDEQERPFSDKFLRDICVNFILAGRDTSSVALSWFFWLLNRNPEVEQKILAEICQIVNERKDAKDKEDLDNLIFKAEEVKKMEYLQAALSEALRLHPSVPVDHKEVLEDDVFPDGTVLKKGTKVVYAIYTMGRMEGIWGKDCRDYKPERWLRDGRFMSESAYKFTAFNGGPRLCLGKDFAYYQMKFAAASILYRYTVKVEKDHPVIPKMALTMYMKHGLKVRLSRRNQTELQKHLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068URX0</accession>
    <name>A0A068URX0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Inositol oxygenase</fullName>
            <ecNumber evidence="4 11">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00033044001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10 11">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 11"/>
    <dbReference type="EMBL" id="HG739134">
        <property type="protein sequence ID" value="CDP11052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068URX0"/>
    <dbReference type="STRING" id="49390.A0A068URX0"/>
    <dbReference type="Gramene" id="CDP11052">
        <property type="protein sequence ID" value="CDP11052"/>
        <property type="gene ID" value="GSCOC_T00033044001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068URX0"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="PhylomeDB" id="A0A068URX0"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF12">
        <property type="entry name" value="INOSITOL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP11052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="245" mass="29210" checksum="7FFD3C6C417C96C1" modified="2014-10-01" version="1">MEKLGKRMLKNCGVFHWPWWFWEEFLELKEHSGNGMKCMRISNPIWIREKRLEKKERKWTGKSASHLFSFSSPTTSDLDKVLLLPSFGGLPQWAIVGDTFPLGCAFDEPIVHQEFFKDSPDHNNPAYNTKHGVYTEGCGLENVLMSWGHDDYMYLVAKENKTTLPPAALFIIRYYSFYALHKAGTYKHLMNEEDVENLKWFQIFNKYDLYSKIKVRIYVDKVKPYYQSLIEKYHYLWYFPSKLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068USF1</accession>
    <name>A0A068USF1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00033747001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739139">
        <property type="protein sequence ID" value="CDP11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068USF1"/>
    <dbReference type="FunCoup" id="A0A068USF1">
        <property type="interactions" value="1219"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068USF1"/>
    <dbReference type="Gramene" id="CDP11475">
        <property type="protein sequence ID" value="CDP11475"/>
        <property type="gene ID" value="GSCOC_T00033747001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068USF1"/>
    <dbReference type="OMA" id="FYCLPRI"/>
    <dbReference type="OrthoDB" id="777433at2759"/>
    <dbReference type="PhylomeDB" id="A0A068USF1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18917">
        <property type="entry name" value="bHLH_AtSAC51_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037546">
        <property type="entry name" value="SAC51-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36066">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36066:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23173">
        <property type="entry name" value="bHLH_SAC51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="325" mass="36159" checksum="004F937BA965A057" modified="2014-10-01" version="1">MNPYLNELYIDGTFPSFTFSGLPQSRASQPNGPCNWFDCLPRFWQSAPGLNSLQKEKLPSELTEKCGRTGIPTASTGCAQKKFLVFDQCDGQTTLIYNSGVGAPMQHPTSWNPKVPAAYDPLMEDLGMKKDMFSNFAPFTSYEHHEDNHGDDVETEMHEDTEELNALLYSDDENEYSDNDDDEVTSTGHSPSTMTEHGIQEWFEERGEEVASSASPTKRRKLLSGDYEVPSPVNALSSGKPRKVSEIEDDAESSCGNFDNQVWEESDSLSGKKRWRKEKIRETVSILQSIIPGGKGKDAVVVIDEAIHYLKSLKVKAKSLGLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTF3</accession>
    <name>A0A068UTF3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00034102001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739142">
        <property type="protein sequence ID" value="CDP11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTF3"/>
    <dbReference type="STRING" id="49390.A0A068UTF3"/>
    <dbReference type="Gramene" id="CDP11671">
        <property type="protein sequence ID" value="CDP11671"/>
        <property type="gene ID" value="GSCOC_T00034102001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTF3"/>
    <dbReference type="PhylomeDB" id="A0A068UTF3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="47" mass="5404" checksum="4DB1BA516E5292CB" modified="2014-10-01" version="1">MQLKLVPGNFAGTITAYYISLRPIDIYFEFLGNLSGQFYILHTNVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UTI8</accession>
    <name>A0A068UTI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00031925001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739133">
        <property type="protein sequence ID" value="CDP10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UTI8"/>
    <dbReference type="STRING" id="49390.A0A068UTI8"/>
    <dbReference type="Gramene" id="CDP10948">
        <property type="protein sequence ID" value="CDP10948"/>
        <property type="gene ID" value="GSCOC_T00031925001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UTI8"/>
    <dbReference type="OMA" id="QPDEIWS"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UTI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="483" mass="53347" checksum="F07BCAA9DEE12AC3" modified="2014-10-01" version="1">MPKPIAIIMPESKEQLVMTVLCCRKGSWEIRVRCGGHGYEGTSSIATDGSAFVIIDLMNLNRVSVDLESQVAWVEGGATLGQTYYAISEASKDHGFSAGSCPTVGIGGHIAGGGFGLLSRKYGLAADNVEDALLVDADGRVLDREAMGEEVFWAIRGGGGGIWGIICAWKIKLLKVPETVTGFILSRPGTKRYVERLVHKWQHVAPKLSDGYYLSVFVGYGLPETAPTIGLSATFKGFFLGPKREALSELNKAFPELHVREGDCKEMSWIESVVYFSGLKPAGSSSSMSISQLNDRYFIDKLFFKAKSDYVRTPISSRGIRAAIDILEKEPKGYVILDPYGGFMEKTDTESIAFPHRKGNLFSIQYMVEWNEKDEQQNRSNGYINWIRGFYGSMSTFVSSAPRAAYINYMDLDLGVMNTSNEMELLMLNGNAPSSDAVERARVWGEKYFLSNYDKLVRAKTLIDPLNVFRHQQGIPPLSTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUD3</accession>
    <name>A0A068UUD3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00033286001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUD3"/>
    <dbReference type="Gramene" id="CDP11193">
        <property type="protein sequence ID" value="CDP11193"/>
        <property type="gene ID" value="GSCOC_T00033286001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUD3"/>
    <dbReference type="PhylomeDB" id="A0A068UUD3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657979" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="7495" checksum="113561D96BE76657" modified="2014-10-01" version="1">MASNKKALITALLFLFFLSTQPILVPSSARKILETNEYGSNDKVYAAKKAASYQPSQPTEGIPIGYGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUN1</accession>
    <name>A0A068UUN1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00033514001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SHL1/EBS protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739138">
        <property type="protein sequence ID" value="CDP11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UUN1"/>
    <dbReference type="FunCoup" id="A0A068UUN1">
        <property type="interactions" value="1826"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UUN1"/>
    <dbReference type="Gramene" id="CDP11328">
        <property type="protein sequence ID" value="CDP11328"/>
        <property type="gene ID" value="GSCOC_T00033514001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUN1"/>
    <dbReference type="OMA" id="PWISNNE"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUN1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04714">
        <property type="entry name" value="BAH_BAHCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000561">
        <property type="entry name" value="Bromo-adjacent homology (BAH) domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000019">
        <property type="entry name" value="Chromatin remodeling protein EBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0287">Flowering</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24592" checksum="ED934E6444FDA978" modified="2014-10-01" version="1">MAKTKPGKKDLDSYYIKGTNKVVRPGDCVLMRPSDPDKPPYVARVEKIEADHRNNVKVRVRWYYRPEESIGGRRQFHGAKELFLSDHYDVQSAHTIEGKCIVHSFKNYTKLENVGVEDYFCRFEYKAATGGFTPDRVAVYCKCEMPYNPDDLMVQCEGCKDWFHPSCMGMTIEEAKKLDHFLCSDCSSDDDAKRSLNSFPVSPSIEKPKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV07</accession>
    <name>A0A068UV07_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00035626001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DH200</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DH200</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739146">
        <property type="protein sequence ID" value="CDP12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV07"/>
    <dbReference type="STRING" id="49390.A0A068UV07"/>
    <dbReference type="Gramene" id="CDP12211">
        <property type="protein sequence ID" value="CDP12211"/>
        <property type="gene ID" value="GSCOC_T00035626001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV07"/>
    <dbReference type="OMA" id="PCHELIE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV07"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000075">
        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000046">
        <property type="entry name" value="probable serine/threonine-protein kinase WNK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="628" mass="70862" checksum="B3EBCC90E4236535" modified="2014-10-01" version="1">MNSRAGSFLSAPNAKLKLEVSENDIILEVSPDKRYIRYNEILGRGAFKIVYKGFDEVDGIEIAWNQVSIDDALQSSENLRRLYSEVHLLRTLKHENIMKLYTSWVDDENKTINMITELFTSGSLRQYRKKHRNVELKAIKNWARQILQGLHYLHNHDPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATMMQQRTVRSVIGTPEFMAPELYEEEYNQLVDIYSFGMCLLELITCEYPYSECKNPAQIYKKVTSGIKPAALGNVKDPQAKQLIEKCLLPAGKRLNAAELLKDRFLSSESSKELLCNLVQPLSITSKATNFCKADSLSMDIEPTYRNVSYDACGESTIETHNVMLHRYNSRNEFRLQGEIRDCHSISLTLRIADFHGRVRNIHFMFYLDADTAISIAGEMVEQLGLLSDDVFLIAELIDCLILEMVPDWKPSFESLAGVGDLNKKSGICQNGHLSTSYSIERGSKSMPCHELIEPHAFTEFIFVDRHDAEESVEKLSEHDQGFTNSLCSSGLGIVAGCKKYGAEVYDGNISESVMSECTKKSGLSIVGSSSAISNDMCFSFSSALLNDKDSEKDQCLDLNLELNAIAVQYDQCCHELLRMREEAMANAKKRWATSKRMPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVX4</accession>
    <name>A0A068UVX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00034232001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739143">
        <property type="protein sequence ID" value="CDP11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVX4"/>
    <dbReference type="STRING" id="49390.A0A068UVX4"/>
    <dbReference type="Gramene" id="CDP11748">
        <property type="protein sequence ID" value="CDP11748"/>
        <property type="gene ID" value="GSCOC_T00034232001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVX4"/>
    <dbReference type="OMA" id="KWQRSEW"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027728">
        <property type="entry name" value="Topless_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083:SF5">
        <property type="entry name" value="PROTEIN TOPLESS-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44083">
        <property type="entry name" value="TOPLESS-RELATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22940" checksum="684DB6D4F40B2B3E" modified="2014-10-01" version="1">MEGSTIADVKPRISDNADRIKCWKFPDIAEADQLKTLRLPQEIWELQILRLLYTNSGLALLALGSNALHRLWKWQRSEWNLSGKSTASIIPQMWQPSSRALMSNDLSEAKPAEESPACIALSKNDSYVMSASGGKVSLFNMTTFKVMTTFMSPPPAATYLAFHPQDNNIIYNGIPSIAIGMEDSTIQIYNVRVDEVYFLVIPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UX26</accession>
    <name>A0A068UX26_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00037456001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739155">
        <property type="protein sequence ID" value="CDP12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UX26"/>
    <dbReference type="Gramene" id="CDP12799">
        <property type="protein sequence ID" value="CDP12799"/>
        <property type="gene ID" value="GSCOC_T00037456001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UX26"/>
    <dbReference type="PhylomeDB" id="A0A068UX26"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021929">
        <property type="entry name" value="R1A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1228">
        <property type="entry name" value="NB-ARC DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12061">
        <property type="entry name" value="NB-LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0611">Plant defense</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Late blight resistance protein R1A-like N-terminal" evidence="14">
        <location>
            <begin position="98"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="13">
        <location>
            <begin position="451"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="15">
        <location>
            <begin position="707"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1156" mass="132018" checksum="658FD694A8405EE5" modified="2014-10-01" version="1">MEFSQLLSELQELRKDDRFFDMDIQELRMILIGQYSLNMPLPDLKRKIKSIAGSLNFCLTKRGSTKPNLSHLSKDLSLRLTLLFGLLHFAKMHGKQIQSIDLVVHCAFLAVNAKCMCKLYKSDHEEEELRGDISQLQQKVKLLGPQIREISVRVLTALKSESISSVTFTLEKNRHRAAGIVYLHLDVLMQLLECYTTFTFQVQDQMLKLHKALRFLIVILAYNGNVLPGGNSAQFNELRDKMKDRIRVVVIDVGIVICSLSVNEMKYGLAKETDLALIDLLKELQFVREAFSKMFPLPSSSSLSFPRTNELGFVEFLLENLKELTRSRANSIAFPIHKIQAVQEDFLSLRYCLEKIAEQRNQNQAIQTFWSHVVEVAYKAEVIIDSALVGDKHESCLDAIARDISILKVEAKEINDNNRNDGKALRATKTFIHMPSQVTAQPSHEDLVGRDDEVKIIINRLKRGSMQLDIIPIWGMPGLGKTTLANKVYCDPSIEFHFYIRAWCCVSQVYSMRSLLLQILHGTGFKSSNQSLEMSDDDLEEKLRKVLRRNKYLIVLDDLWDIEAWNLLKRSLPDDANGSRILFTSRFENFSSQIKQDSKPHHLRLLTDEESWQLLQNKLFGKGVCPPTLSKVGLRIANNCRGLPLTIILIGGILATTERDCAIWEEVAKSLSSGNVPDTERWMKTLELSYSHLPDYLKPCLLYFSAFQEDRDISVQRLLWLWISEGFVQKSEGKSFKDVADEYLMDLTARSLVMVTKERTMGGAKACRLHDLVHEFCVVKAKEESFLQIFHGDDVVTYTGLSNPYRLFIYSMKSSTLEELKLFLPNLRSLLFFVDYDGIHHKLDLSPHGFLLPRLLRVLDLRKLFLGEDFPMELVSLVHLRYLAIRGHIEYIPSAIANLSKLESFLLKGSGANVVLPNTIWNIKTLQHLRTSSFYGFIFPFDNLEVCPDLNNLDTLSLAVDPHSQSLQKILKKLPSIRRLKCVGDKSGESTANCNKILTLSYLSRLESLNLDAFVGYEFEFPSSLKKLTLWSNHQPWSSISRIGKLPNLEVLKLRYQAFVGEKWEVEEGEFPNLRFLKLSSLDIHRWTASSDNFSLLEKLVLHDCVKLEEVPSCLGESPTLEMIEVSSCGKSTVNAIKQIQQEQMDMGNEALKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXF6</accession>
    <name>A0A068UXF6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00037657001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXF6"/>
    <dbReference type="STRING" id="49390.A0A068UXF6"/>
    <dbReference type="Gramene" id="CDP12949">
        <property type="protein sequence ID" value="CDP12949"/>
        <property type="gene ID" value="GSCOC_T00037657001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXF6"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXF6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 55 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="59" mass="6643" checksum="E67B69A71E3C002A" modified="2014-10-01" version="1">MSRSYHLCSWGIVLQILACALYNNWWPMLTVIMYVVLPMPLIFLAGSDTSSLFSESQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYI5</accession>
    <name>A0A068UYI5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00038190001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYI5"/>
    <dbReference type="Gramene" id="CDP13299">
        <property type="protein sequence ID" value="CDP13299"/>
        <property type="gene ID" value="GSCOC_T00038190001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYI5"/>
    <dbReference type="OMA" id="MPRINEY"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYI5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33417">
        <property type="entry name" value="G-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10198" checksum="CA5C94863FF64BE7" modified="2014-10-01" version="1">MGGYSRWIKPEVYPLLAPVAAVVGLCTMQLVRNICTNPEVRVTKENRAAGVLNNFEEGEYYAQHRLRQFLRGRRPEVMPSVNKFFSDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UYT6</accession>
    <name>A0A068UYT6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00038346001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UYT6"/>
    <dbReference type="STRING" id="49390.A0A068UYT6"/>
    <dbReference type="Gramene" id="CDP13414">
        <property type="protein sequence ID" value="CDP13414"/>
        <property type="gene ID" value="GSCOC_T00038346001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UYT6"/>
    <dbReference type="OMA" id="LVWGSDE"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UYT6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF123">
        <property type="entry name" value="OS04G0645500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="233" mass="24973" checksum="F7E4699E6F6E5451" modified="2014-10-01" version="1">MGIREIEVATGNKLFIHELEDVCDSVTGRALTGSWIWDLAVVLSNWISARAQLDYDLSNKTVLELGAGTGLPGLTAARLGASRVVLTDIKPLIPLLEKSVEVNGLGDRVLACQLTWGSDELPSQLNELGHVDLVLLSDVFFDAAEMGGLAKTLKKVCGKETTVWGATEVRPWTTASLGELESEGFGIVELSSQLSDGLHGEVTGGDQEEISVFQLVPPGQDCEPLEAWSPIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZG3</accession>
    <name>A0A068UZG3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sororin C-terminal region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00039080001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the sororin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZG3"/>
    <dbReference type="Gramene" id="CDP13935">
        <property type="protein sequence ID" value="CDP13935"/>
        <property type="gene ID" value="GSCOC_T00039080001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZG3"/>
    <dbReference type="OMA" id="NYWREHF"/>
    <dbReference type="OrthoDB" id="1903589at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZG3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057337">
        <property type="entry name" value="Sororin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35740">
        <property type="entry name" value="OS12G0111700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35740:SF1">
        <property type="entry name" value="OS12G0111700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25220">
        <property type="entry name" value="Sororin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sororin C-terminal region" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="401" mass="43734" checksum="16570207756F27FD" modified="2014-10-01" version="1">MQRIKRHTTKIPSASAAAAASRSSKSVNNNEISCSANSTATVRKPLSDLSNFNLIPTDTLRKLVSSNSVSNSETHSLLLKSQTSIFPISQIPLISGSHKHNGNPKSDTRSGTSVGSSNFGNDPKTKPQNPTPVRHQLPPRSSTNPSDEGSELVIYSRRRGERKHNVLPKTSTPFEKKKNEEKAASVPLSSTPAEKAKNKGKAIAMPFDSIAAEKSKDQGKLVTVPVDSIPAGNSRDKEKGISASFRPSNVEKTRDKGKDFYAPSNSTPVEKMRDKGKAIAVPVNCTLEEMEDRRRSTAVLINSEQLTKQRQKRLADAMVQSCPPLLKSGKFGNELNQAGDDMLSKSWTGLQGKHKKRKCPGKQSASEGSLSPEFVKKMKAYFEEVDAFELPVEEVSDHDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UZK0</accession>
    <name>A0A068UZK0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00038958001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739161">
        <property type="protein sequence ID" value="CDP13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UZK0"/>
    <dbReference type="FunCoup" id="A0A068UZK0">
        <property type="interactions" value="1629"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UZK0"/>
    <dbReference type="Gramene" id="CDP13846">
        <property type="protein sequence ID" value="CDP13846"/>
        <property type="gene ID" value="GSCOC_T00038958001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UZK0"/>
    <dbReference type="OMA" id="CNEATKE"/>
    <dbReference type="OrthoDB" id="2018787at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UZK0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23550" checksum="0C4A92B3AA94FB21" modified="2014-10-01" version="1">MAFRGRGRGRGGFGGGGFRAAKQEKFDLFPEIEELGTAEGVKVDPSFAVWYSKFQRYWNSSPYYVEDESGGAKKSQSTEIEKYSDRKSKKKSSKQPLSHFIRMEPDYVPAELAKGEKKEKHGAKRVRWNPEADMKKLDVFEKLEQKHQGQEISEKEDEEEEDEKLEEEEEEYSDDGDYNQNIDFDDDEDDFNMGDDNDDEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0M2</accession>
    <name>A0A068V0M2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 25 member 44-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00038393001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739159">
        <property type="protein sequence ID" value="CDP13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0M2"/>
    <dbReference type="Gramene" id="CDP13443">
        <property type="protein sequence ID" value="CDP13443"/>
        <property type="gene ID" value="GSCOC_T00038393001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0M2"/>
    <dbReference type="OMA" id="GSIGCYC"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0M2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36451" checksum="E3C0C8F6B05F875F" modified="2014-10-01" version="1">MSLGAAEEDSASEIHLPADIDWEMLDKSKFFFLGAALFSGVSATLYPVVVLKTRQQVMLNGTPCLKMAASILRNEGLRGFYSGFGTSLMGTIPARALYMGALEMTKSNVGSATVQLGLSEAYASAVANAAAGLSAAMAAQLVWTPVDVVSQRLMVQGSCCSNVRSGNAVALKSYSGGIDAFRKIVYSDGIRGLYRGFGISILTYAPSNAVWWGSYSVVHRTIWGCVGGYGCKKDENGYRPDGKAVVAIQGISAAMASGVSTLVTMPLDTIKTRMQVLDGEGSGRRPPTILQTVRNLVKEGGFSACYRGLAPRWASMSLSATTMITTYEFLKRLSTKNQDRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V111</accession>
    <name>A0A068V111_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00038582001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V111"/>
    <dbReference type="FunCoup" id="A0A068V111">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V111"/>
    <dbReference type="Gramene" id="CDP13583">
        <property type="protein sequence ID" value="CDP13583"/>
        <property type="gene ID" value="GSCOC_T00038582001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V111"/>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="1886586at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V111"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP13583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="154" mass="17113" checksum="D6EA09C7D3C8F7CA" modified="2014-10-01" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGTMIKVKTLTGKEIEIDIEPTDTIDRIKERVEEKEGIPPVQQRLIYAGKQLGDDKTAKDYNIEGGSVLHLVLALRGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V169</accession>
    <name>A0A068V169_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BURP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040495001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V169"/>
    <dbReference type="STRING" id="49390.A0A068V169"/>
    <dbReference type="Gramene" id="CDP14224">
        <property type="protein sequence ID" value="CDP14224"/>
        <property type="gene ID" value="GSCOC_T00040495001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V169"/>
    <dbReference type="OMA" id="PYPYTVF"/>
    <dbReference type="OrthoDB" id="1909293at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V169"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044816">
        <property type="entry name" value="BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004873">
        <property type="entry name" value="BURP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31236:SF32">
        <property type="entry name" value="BURP DOMAIN PROTEIN USPL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03181">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01045">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51277">
        <property type="entry name" value="BURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655467" description="BURP domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="BURP" evidence="2">
        <location>
            <begin position="85"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="309" mass="34434" checksum="E7C929109E0CBB8E" modified="2014-10-01" version="1">MDSKALASCVLLLHLLIVLGACDIIPKAKYSGTNAIRLQGMDANNPHRNDKTHHVAHVHEKKSMHDPSLSSSHMMHQMDPRATVFFVLDDLKLGKTLSILFPDGDPSPLSSPYLWPREQADAIPFSLAKLPQILQHFSFPQGSHQAQVMEHTLRACETKPMKGESRACATSYESLVDFARKILGLNTDIEVLSTHRLAKSNAARLQNYTITEAPKRISTLKMVGCHTMPYPYIVFGCHYQRGDNHLYRTVLSGENGDRVEATARCHMDTSQWSHDHVSFRVLGIEPGTAPVCHFFPAEDFVLVPSTSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V195</accession>
    <name>A0A068V195_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00038672001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739160">
        <property type="protein sequence ID" value="CDP13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068V195">
        <property type="interactions" value="2591"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V195"/>
    <dbReference type="Gramene" id="CDP13653">
        <property type="protein sequence ID" value="CDP13653"/>
        <property type="gene ID" value="GSCOC_T00038672001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V195"/>
    <dbReference type="OMA" id="GCQHNEK"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V195"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="6">
        <location>
            <begin position="310"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="6">
        <location>
            <begin position="521"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="5">
        <location>
            <begin position="1736"/>
            <end position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1821" mass="204340" checksum="D5E444932334C05C" modified="2014-10-01" version="1">MHLYNAWLPPAVAEETKKEKESFHKVLKAVKESYKVDDPESVYATLKWVSVIDLFIKAKSELLMEDVTAVVETGLELFQISENKLHVQVRWGNLLVKILNKYRKKLSLKVQWRPLYDTLIHTHFKRNTGPEGWRVRQRHFSTVTSLVRSSRRFFPPGSAFEIWSEFRSLLENPWHNSSFEGSGFVRLFLPTNLDNQDFFSQEWMNLCLDHWDSVPNSQFWNSQWASVTARVIKNYKFIDWEKFLPTLFNRYLNMFEVPVANGSGSNPFSVDVSRNTRFLFSNRTVTPSKAIAKSIVYLLKPDGAAQKYFEKLVNLLEQYYHPSNGGRWTYSLERFLAYLVHIFHKRLLHEQMSSRDDGKKSELFLQQPDRLSFINALLKLIDRGQYSKNENLSDTVAAATSVLSYLEPSLVLPFLASRFHMALETMTATHQLKSAVTSVAYAGRSLFLTTLSCSPFKQDDFGGTDSFSDLLMIALSNALFGLDANDPPKTLATMQLIGSLFSNMALLEDSTNELSPLPEFQFSEWLDEFLIRLFSLLRHLEPSGVLNEGVHSSTTSGTILVEDGPYYFCMLEIVLGRLSRALYKQALNKISKFVKSNILPGAIAEVGLLCCACVNSNPEEAVLHIVEPILLSVISSLRETPVTGYGGRRTSVAIGRSKQCFFQEKATLSPALETNIEYQLKVLSVAISYGGPALLRYKDEFKEVIFSAFDSTSWKVNGAGDHVLRSLLGSLIHYYPIDQYKCLLRHSAAASLEEWISTKDFSNAVPPVGPKWHIPCDDEVEFANELLKLHFDCALDDLQKICQSKIHCDPGNEKEHLKVTLLRIDSSLQGILSCLPDFRPSVGNGMVEDSGLFSFLIAGATGSLVGSTELREKAAEIIHAACKYLLEEKSDDSILLLLVIRIMDALGNYGSSEYEEWSSHRQAWKLESAAIIEPPINFIVSSHSKGKRRPRWALIDKAYMHNTWRSSQSSYHLFRTSGNISPSDHVLILLDDLLNLCLHSYETVRTLAGKSLLKMLKRWPSTISSCVYALSENLKAPSSPEYAVLGSCAVLSTQTVLKRLTSDAKALCCFLRGILSSSHHESLKSQKAITELFVKYNIYFEGIPRSILRTSGIHSDATDFSDLVSEIGSMSFESTNLHWRYNLMANRVLLLLSMASANDPHSSTNILKETSGHFLKNLKSQLPQTRILAISALNTLLKESPYKVSAGNPVFIGDVQGNTKSSLEGALSIIFQEEGFFNETLSSLSHVHIIADADSASSRGHHGNSSFQSLADKSITHFYFDFSASWPRTPNWISLLGSDTFYSNFARIFKRLTQECGMPVLLALRDALIEFVNSQERSKQCVAAEAFAGVLHSDVAGVSEAWDSWMMTQLQNVIYSQSVESVPEWAACIRYAVTGKGKYGTRVPLLRQRVMDCLMTPLSQTVTSSVVAKRYTFLSAAFIEISPQRMLRGETELHFTLLKELVCNMSHSSAQVRESIGVTLCVLCSNIRLHESCSPSNSLEGVRGDVYGNFEGGSWDEYIVQRASELAVNIHNISACDILETSSDKTLHNGISKDHSRDDVNWMETVFHFVISSLKSGRSSVLLDVIAGLLYPIISLQETSNKDLSTLAKAAFELLKWRVFHGTRTQKAISLILSLGSDSNWRTRSATLTFLRTFMYRHTFILSNVDERQIWHTVEKLLADNQIEVREHAAAVLAGLMKGGDADLAEDFRNRAFREANVILKKRRQRNLRSGLSVASIHGPVLALAACVLSIPYDMPSWLPEHVTLLAHFVSEPSPVKSTVTKAVAEFRRTHADTWNIQKDAFSEEQLEVLADTSSSSSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1V4</accession>
    <name>A0A068V1V4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00041066001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1V4"/>
    <dbReference type="FunCoup" id="A0A068V1V4">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1V4"/>
    <dbReference type="Gramene" id="CDP14547">
        <property type="protein sequence ID" value="CDP14547"/>
        <property type="gene ID" value="GSCOC_T00041066001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1V4"/>
    <dbReference type="OMA" id="FDMSVET"/>
    <dbReference type="OrthoDB" id="513574at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V1V4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021788">
        <property type="entry name" value="CPP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33372">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33372:SF10">
        <property type="entry name" value="OS03G0137300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11833">
        <property type="entry name" value="CPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="213" mass="22271" checksum="4C55422EB9E0A03B" modified="2014-10-01" version="1">MSLENALKVLGISEGASFEDIVRAKNSILASSNDDKATIAKVEAAYDMLLMQSLSQRRAGKVVSSSIRYADVKPVSAPKLGPMPQWLKNSVSVEAPSTGDLGIQAGVYGALMVLTYVNGASSSAAPYAGADVPGLILASSFGASLYFITKKNVKIGKATLFTIGGLVAGAVVGSTVENWLQVDIVPFLGIHSPATVVSEFVLLSQFLVSLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2C1</accession>
    <name>A0A068V2C1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00042244001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2C1"/>
    <dbReference type="STRING" id="49390.A0A068V2C1"/>
    <dbReference type="Gramene" id="CDP14786">
        <property type="protein sequence ID" value="CDP14786"/>
        <property type="gene ID" value="GSCOC_T00042244001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2C1"/>
    <dbReference type="OMA" id="GNEEHIM"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2C1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000028">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF18">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 38 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="216"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="466" mass="51858" checksum="9FB03552A7BDD056" modified="2014-10-01" version="1">MAMEIDQSEDNVAKKLKENEEAVTKDLSNFTSIAGSGSGSLSVENVNSSNSDLSYHDDGNDKQDAVDDDVSDYDDNDDYMFDDDDDDGDYLSMQAQFDNVDLPPGVEASVSWLQASSMSASIPTPPAVTTQFHTAAPSADAGSSSFVNLCPHKNEISASSSSAVTVESSSNGNEKEESEDEIMRKYEAFKSFDTVEDFSDHHYTNMGFKGQQPPKAWTKKIHDEWKILEKDLPDTIFVRVYEARMDLLRAVIVGPQGTPYHDGLFVFDVHFPSNYPDVPPMVYYYSGGLRLNPNLYDCGKVCLSLLNTWSGKGNEKWMPQTSTMLQVLVSIQALILNAKPFFNEPGYDTHYVGAEGERRSKEYNENVFILSLKTMMYTLRRPPRHFEDLVAGHFRIHACDILTACKAYMEGAPVGSLVKGKAPDVEAADKSMSKDFKEAVAKMMNGLVSNFTKYGAKDCEQFRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2S2</accession>
    <name>A0A068V2S2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA carboxyltransferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00040417001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2S2"/>
    <dbReference type="STRING" id="49390.A0A068V2S2"/>
    <dbReference type="Gramene" id="CDP14168">
        <property type="protein sequence ID" value="CDP14168"/>
        <property type="gene ID" value="GSCOC_T00040417001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2S2"/>
    <dbReference type="OMA" id="FAMSEQC"/>
    <dbReference type="PhylomeDB" id="A0A068V2S2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42995">
        <property type="entry name" value="ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42995:SF5">
        <property type="entry name" value="ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="52" mass="5759" checksum="C9E70F3A383E31CA" modified="2014-10-01" version="1">MQEGRLSLMLMAKISSALYDYKINKKSFYVSILISPTTGGVTASFAMSEQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2W8</accession>
    <name>A0A068V2W8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucan endo-1,3-beta-D-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00040435001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2W8"/>
    <dbReference type="FunCoup" id="A0A068V2W8">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2W8"/>
    <dbReference type="Gramene" id="CDP14183">
        <property type="protein sequence ID" value="CDP14183"/>
        <property type="gene ID" value="GSCOC_T00040435001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2W8"/>
    <dbReference type="OMA" id="QDNANTW"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2W8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000010">
        <property type="entry name" value="glucan endo-1,3-beta-glucosidase, basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655362" description="Glucan endo-1,3-beta-D-glucosidase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37020" checksum="84F92732EEA9A0D5" modified="2014-10-01" version="1">MAGAEQQFKAAVFVIGLLLLAALDYTGAQTGVCYGRLGSNLPSPADVVALCNQNNIKRMRIYDPDQSTLQALGGSNIEVILGVPNTDLQNVAASQDNANTWVQNNVRNYPNVKFRYIAVGNEVSPIKGDTAQYANFLLPAIQNIFNAISAAGLGIKVSTAVETELVGNNFPPSGGTFKPEVQNFINPIVQFLASKGAPLLVNVYPYFAYIFNSQSIALEYALFTSSGITTPDGVKYQNLLDALLDATYSALERAGGQSVEIVVSETGWPSDGGGQATSIDNARTYNTNLIGHVNGNSGTPKRPGRAIETYIFDLFDEDQKSPDYEKHFGLFLPNRQPKYPISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V3E7</accession>
    <name>A0A068V3E7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00042652001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V3E7"/>
    <dbReference type="STRING" id="49390.A0A068V3E7"/>
    <dbReference type="Gramene" id="CDP15087">
        <property type="protein sequence ID" value="CDP15087"/>
        <property type="gene ID" value="GSCOC_T00042652001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V3E7"/>
    <dbReference type="OMA" id="YETRSHW"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V3E7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45136">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45136:SF2">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="362"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="651"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="824"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP15087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116534" checksum="D00740A9182FBF00" modified="2014-10-01" version="1">MEESEPENKKKKTRNPRTSQGSLRLVLKHADLLDTLLMILGTIGCFADGSSVAANMLVLGSLMNSYGRAASAFNPDDINKYALELFYVAVLVGSGAFLEGFCWARTAERQTSRLRTRYLQAVLRQDVGFFDKVDGTSMTSQVVLSISTDTLTIQGVISEKIPNFITNMAMFTTAQLAALYLSWRLAVIGIPALLMLIIPGLVYGKLLSSVGQKIQEAYAVAGGIAEQAFSSIRTVFSYVGEQQTTSRFSSALEPTLNLGIKQGLLKGMAIGSIGLIFAVWALEGWYGSILVIEKGLKGGDCFTAGVCIIFGGVALGSSIVNIKYFAEANIAAATIFQMIERIPSIDSTDPKGETINDVKGELEFKDTDFAYPTRPDNLVLRKFNLKVIPRQTVGLVGGSGSGKSTVINLLERFYDPLGGEVLLDGINIKTLQLKWLRKQMALVSQEPILFATSIKENILFGKAEASEEEIIQAAKAANAHNFITQLPEGYDTLVGELGIQMSGGQKQRISIARALLVNPRILLLDEATSSLDSHSEKAVQNALNQVSQGRTTLIVAHRLSTLRNADAIAVIRSGQVVDFGSHDELVQNKYGPYSLMVQQQKKLMNDEIICTPKEAEQKDQEVMDQEYSPPTYLQLLKMTTPEWSSTLLGSLGALLYGFVHPLHSFCLGALISNLTKRVREATMAKILTFETQWFEQEGNSTGALCSRLAKDATLVRSLVADRLAFLIQSISGVTLAVILSLVLAWRIALSQNRSNELASEAVGNHRIITAFYSQDKVMTLFQKAQVGPKKESRKQSWYAGLGLFTSQFLGATNMALLFWYGVELKEVDFFYPTRPKQLILNNLSLTVEAGEVVALVGQSGSGKSTIIRMIERFYDPSKGSVEIDGIDIKLYNLRALRSHIAWVGQEPCIFAGTIHENIAYGTQGATEAEVVEAATLANAHEFISSMQDGYGTYCGERGAQLSGGQKQRIAIARAILKKPRIFLLDEATSALDVKSENLVQDAFDKTMTGRTCLIVAHRLSTIQKSNKISVVDNGRIIEEGSHDDLLAKGESGAYHTLVKLQHQATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4L8</accession>
    <name>A0A068V4L8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00015381001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDP15522">
        <property type="protein sequence ID" value="CDP15522"/>
        <property type="gene ID" value="GSCOC_T00015381001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4L8"/>
    <dbReference type="OMA" id="MENPKSD"/>
    <dbReference type="OrthoDB" id="847710at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="164" mass="17786" checksum="0127401B45E0E5EC" modified="2014-10-01" version="1">MADESKTSHSSPATWAVQEPTNSDSGDDPHPPPPTTTDGGYEAGEKDPEDQEHVREAKRRRICPSALDKCESIIKSCCSNNSNCLTFSFDPKFSCGASTPEVTPKFGSFNLVAAAGISTEIQEKAAEEKEEEEEEEEEEKDDEIKEKSNNVLEVLGSTDGLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4V1</accession>
    <name>A0A068V4V1_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00015892001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739193">
        <property type="protein sequence ID" value="CDP15790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4V1"/>
    <dbReference type="FunCoup" id="A0A068V4V1">
        <property type="interactions" value="1578"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V4V1"/>
    <dbReference type="Gramene" id="CDP15790">
        <property type="protein sequence ID" value="CDP15790"/>
        <property type="gene ID" value="GSCOC_T00015892001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4V1"/>
    <dbReference type="OMA" id="DDHRANG"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4V1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019450">
        <property type="term" value="P:L-cysteine catabolic process to pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF9">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="87"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="451" mass="50013" checksum="593896817D447935" modified="2014-10-01" version="1">MEDPQANGDHNHNHIPKKLKLSSPSSFISDSEIRQEFAHHQLGIARINNGSFGSCPASIIAAQKQWQLRFLQQPDDFFFNHLQNGILRSRTLITSLINADHVDEVSIVDNATTAAAIVLQHVGWAFAEGRFQKGDAVVMLHCAFQAVKKSIEAYVTRAGGSVIVVQLPFPVHSDQEIIAEFRKGLAMGKAHGRKVRLAIIDHITSMPCVVIPVRELVQICREEGVEQVFVDAAHAIGSVHVDVKEIGADFYVSNLHKWFFCPPSVAFLYCRKSPIALDLHHPVVSHEYGNGLAIESAWIGTRDYSSQLVVPDVLDFVNRFEGGIAGIRKRNHDAVVRMGELLARAWGTHLGSPPEMCPSMAMVGLPSSLRISSDDDALKLRTHLRDHFEVEVPIYYQALKDGEIGGDNWDGRVAGYARISHQVYNTVDDYLKLRDAINQLVKDGVTCNNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V532</accession>
    <name>A0A068V532_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00016795001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V532"/>
    <dbReference type="Gramene" id="CDP15890">
        <property type="protein sequence ID" value="CDP15890"/>
        <property type="gene ID" value="GSCOC_T00016795001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V532"/>
    <dbReference type="OMA" id="HEMIREN"/>
    <dbReference type="PhylomeDB" id="A0A068V532"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="175"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="10">
        <location>
            <begin position="433"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="11">
        <location>
            <begin position="662"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP15890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="111240" checksum="B4153C9C9EC179AA" modified="2014-10-01" version="1">MADTVLSFVSVILDKILPLAADEISWAWGVKKDLKKLADKLKMMQALISDAKCKQSTRESTREAVQLWLKRLQSIARDAEIVLDDFGYEVLRQKVENRKRDKVRNFFSSSNPISFRLEMANKIKNVRASLEEAYREANQIGFHPAQLPMASADHKQDRSTDPFVDESQTVGRGDEVSEIVSMLISSDYEKDLPVISIVGMGGQGKTTLAQMVLKNDSVVKHFDKTIWVCVSDDFKVERLLNEMLQSLERKSADTTNTEALVRKLQENLKGKSYLLVLDDVWNEDREKWDGMRRRLLAIGGGPGSKILATTRSDEVASAMQTSGLHHLDILSDDHSWMLFEKLAFAAGGARKTQDLVDIGRKILKKCGGVPLAIKVIGGLLYSKKDASEWLNLENSEIWNESTNTEGGVMSVLKLSYENLPSLSVKQCFASCSIFPKDANMRKESLIQIWMAQGLINDAKGGGHLQMEDIASDCFNVLLRSSLLQAGYKNSINGIRSCRMHDLVHDLSLRVSNNCFLNTENGMVVRIPPNLQTLYYIGDDGIMLEDILERSKYLSVLKVDCWDVTHLPNAVGNMKHLRHLDMSQTRIAALPDSITKLYNLMTLKVRYLLKIPKKFSNLINLRHLEFSSGFGDGHRCLFPGIGQLANLRTLPHFRVSQDKGCQLEELEHLRNLRGELKIFGLENVSSFESAAKAKLSEKSSIQSLTLEWDGTKEDCDDDNINSVMEGLQPHPDLKSLAINRFEGSRFPPWMVAKDHVTVLLRNLVHLRLEKLARCEQVPSLGDLPCLESLEMVSLHNVKRIGAEFYDGKPVTLFPKLSSFALCGMKSLEEWSDAMVFPNLRDLRISGLPKLAVLPDMENLTSVTELRIWECRSLACLRNLNSLTSLESLSIDDCPALLDASLDMKNPQSLRELTISGCDKLNPSLSNNLVSLEHLELRGWPKITSLPDQIQHLSNLRTLLLCNCPLLAERCTKGSGAEWPKIAHIPQVDIHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7H9</accession>
    <name>A0A068V7H9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00016753001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V7H9"/>
    <dbReference type="FunCoup" id="A0A068V7H9">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7H9"/>
    <dbReference type="Gramene" id="CDP15858">
        <property type="protein sequence ID" value="CDP15858"/>
        <property type="gene ID" value="GSCOC_T00016753001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7H9"/>
    <dbReference type="OMA" id="DKKEMHY"/>
    <dbReference type="OrthoDB" id="1931494at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V7H9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677">
        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677:SF228">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP15858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="220" mass="23493" checksum="FD71328D13E8434D" modified="2014-10-01" version="1">MAMKEKSKDVKPSTGKANAVKEVHFRGVRKRPWGRYAAEIRDPSKKSRVWLGTFDTAEEAARAYDAAAREFRGPKAKTNFPSPSEIQSPSNSSTVESSSGDGSTHAPVELDLTRRLGVAAGGGGAGSEIPILHHPQAMAVLPNGQPVVFFQPMALNRADYPYRFGPVAMDYANVVGRGRGAVHSDSDSSSVVDDNISDGDNMKRGGGLDLDLNFPPPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V7W4</accession>
    <name>A0A068V7W4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00019098001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739219">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V7W4"/>
    <dbReference type="Gramene" id="CDP16642">
        <property type="protein sequence ID" value="CDP16642"/>
        <property type="gene ID" value="GSCOC_T00019098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V7W4"/>
    <dbReference type="OMA" id="WDPVLHW"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38660" checksum="D0DF54E74F72C66C" modified="2014-10-01" version="1">MASAMVLRKTPKTLHYYSYALRTLPSELRQLSGVATAGKLQPQSQPEHADPSSSSSFTFSSDENANASRTKTNEEEDPIYVKGLKTTASSSSSQSDSVSMPMSFMTGSIVGKRFYQNVNTRKADDGNGWTVMLDYRTLKSPSKRPLKCPTPALAMAVAAEWDYQQTDGIRPFTMPLMKLACTALERVPLTRPKVIENLMKKFHQDLVFCRAPADNDLTKGVFERQVEKIDPLLKWLESEFGYKPVIYSSFFGGKQQEGLVTAIEGLLKRTNDCELAAIDAIAAAAHSLVIAIGIFRGRLNIEEAIELIRLEEDLQVDSWGLVEGGHDVDIADLKVQVASAAVFLGLCRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8I5</accession>
    <name>A0A068V8I5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF223 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00004787001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739225">
        <property type="protein sequence ID" value="CDP16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8I5"/>
    <dbReference type="Gramene" id="CDP16966">
        <property type="protein sequence ID" value="CDP16966"/>
        <property type="gene ID" value="GSCOC_T00004787001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8I5"/>
    <dbReference type="OMA" id="GHEDSFY"/>
    <dbReference type="OrthoDB" id="1725660at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8I5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19648" checksum="FCBC285369CE4C2C" modified="2014-10-01" version="1">MSRHISSVLDIQKGAEKWTVLAQVVHRGHNQLTREVPPRRIMRFLLTDTEGTKVSVVTYEQHIKIFSKFLQPYQRYYVSNAIVVPADPTYKVGSYECSWILNYKTLIENYAEPVPPMLPCVFELTNFSDLHKYADSDNLCNIRGFVIHAFPVKQVDPDCTSRDIIIVNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8P6</accession>
    <name>A0A068V8P6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00004920001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8P6"/>
    <dbReference type="FunCoup" id="A0A068V8P6">
        <property type="interactions" value="2308"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V8P6"/>
    <dbReference type="Gramene" id="CDP17021">
        <property type="protein sequence ID" value="CDP17021"/>
        <property type="gene ID" value="GSCOC_T00004920001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8P6"/>
    <dbReference type="OMA" id="HRCSWRS"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8P6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="13">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP17021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="463" mass="51822" checksum="F9F280B2D0155B9D" modified="2014-10-01" version="1">MVDLKSERCQFWLPKKNRLCANAPLPNSSFCGNHTQRSNHQWIQCPLDPSHSVLQHNLENHLTRCPSLKQAQSLSLQPYYQKGINAGGGIDEDHTATASHMKRRAIYNKTVPEFCDLIRKIKSIHASLSDNTRIQDSFKIPQACAVWSTRRQIDRKLPFQEKHVLQQASILGNLEEFGLLPKSGVEDAVIDARTLDRSDVDVPAVVEFGAGRGYLTQLLADCYGIKKVLLVERKSYKLKADRSLRQIENLLLERLRIDIEDLNLNAVESLQGVPYLAIGKHLCGPATDMTLKCCILEQSAQNHADQLKASCFLRGLAIATCCHHLCQWKHYINKNYILNLGLTKEDFHAMTWLTSWAVDADHGSDIFVVDSSPNLSLNEKEEIGAELSQSGVGDVVRNMSAVERAVVGFMCKDIIDAGRLMWLKELGLHSQVVKYVPPGISPENHLLIARQGNGLYDDSVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V8Y1</accession>
    <name>A0A068V8Y1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">S-acyltransferase</fullName>
                <ecNumber evidence="8">2.3.1.225</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">Palmitoyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Calcineurin B-like protein</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00004921001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with CIPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V8Y1"/>
    <dbReference type="STRING" id="49390.A0A068V8Y1"/>
    <dbReference type="Gramene" id="CDP17022">
        <property type="protein sequence ID" value="CDP17022"/>
        <property type="gene ID" value="GSCOC_T00004921001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V8Y1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V8Y1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045198">
        <property type="entry name" value="CNBL1-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056">
        <property type="entry name" value="CALCINEURIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056:SF116">
        <property type="entry name" value="CALCINEURIN B-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="304" mass="35036" checksum="DE0F5ADE05C74E8B" modified="2014-10-01" version="1">MLRCLDGVKHLLAVVVNCCDSEIYKQPRGLENPEALARETIFSVSEIEALYELFKKISSAVIDDRLINKEEFQLALFKTNKKESLFADRVLSANVFDLFDTKHNGILDFEEFARSLSVFHPNAPIDDKIECNHLSFYFLFLLYAVVSCIYSLVYQYISFSSKTVDSTTDEEQNKGFFRAAYVISGILLVPLTLALTIFMFWRVYLILQNKTTIEYHEGVRAMWLAEKGGYLYSHPYDLGTYENMISVLGPNIFCWVCPTSEQIGSGLRFRTNNLMVLYHLLMAIKLWCPHAFFLEIQPLKKCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V9R5</accession>
    <name>A0A068V9R5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00011454001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739250">
        <property type="protein sequence ID" value="CDP17515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V9R5"/>
    <dbReference type="Gramene" id="CDP17515">
        <property type="protein sequence ID" value="CDP17515"/>
        <property type="gene ID" value="GSCOC_T00011454001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V9R5"/>
    <dbReference type="PhylomeDB" id="A0A068V9R5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="215"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="384"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="615"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP17515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="120210" checksum="696D7E1A1E4E4C85" modified="2014-10-01" version="1">MADAAVSATIRVALQTVVSLAADHVNLAREFPKELERLEKSAAMIRGFLAGADKDMRRPGVQNWLEQLEDEVFKADNVLDELNYKNLRRKVKYQNQPLKKKVLFCFSFFNKIGFRWSLGSTIREINTNLERIHGHARGLGLECKGQVEETSGAATSRQTDSKIVRSDVLGRDEDESKIVKKLLTESESDRISVISITGPPGLGKTTLAKAVIVEGIETELKEKRYLLVLDDLWNHQEGLLNDCFTTLEALKPKKGSWCLVTSRLQEVAIVLSRHRRINFTCHDLGKLYDDDCWSIVKNWATVGEEVPKELEDTREQVLRRCDGLPLAATLIGGLLSKKRKEDWLSILEESLLNGDQGGIEQILKVSFDHLSPAPVKKCFAYCSIFDQDTKLEQDLLVEHWMAEGFLQPDTQNERMMEQIGYEYLRILLQTSLLEEVKEERRTWYKMHDLVHDFAKSILNRSSSNQDRHLAVYSSERTNEKASASLRTLFLEGGMADDMLSKFKYLHVLKLFGADVKELPTSIGKLIHLHLLDISGSWITILPKSLCKLYCLQTLRIGKLEEGFPKKMSNLISMRHFHYDDDAGRKIQMPSSIGRWTCLQTLEFFNIGHQEEGRGIQELGTLQDLKGSLEIRNLELVNGKDNAKLANLSKKPNMHRLVLEWGNRDPESDKCDEDVLEGLQPHPNLKELHIRKFRGNHIPQWLVKSSTLVELHLINCRELPVPTLSSLQHLYGSGTTSIQTFFPALKILSLECMKNLEEWKDANVMDVFPVLEKLYIRDCPQLTTIPTPMIRPENSLSIDGRDSLSTDMLERLCLFPSLQSVELWFCSNITTLRGMSCAACLKRLVVIDCENLWELPEDLYQFQALDLLKSLEKLTIGDCKGLTRFPVEMFESCTSLRELQLLNCPNLVSFPLDLRRTPSLEVFSLKSCPNLITEMPSGFGYLTSLRGLLIGPILDYSVMEFDWAGLASSSTLRYVSLWGMPDTKSLPHQLQNLTTITSLRLQNFGAIEALPDWLGNLASLEELFLFSCQKLEYLPSIAAMERLKLRSLEIYYCPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA58</accession>
    <name>A0A068VA58_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00002930001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739243">
        <property type="protein sequence ID" value="CDP17429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA58"/>
    <dbReference type="Gramene" id="CDP17429">
        <property type="protein sequence ID" value="CDP17429"/>
        <property type="gene ID" value="GSCOC_T00002930001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA58"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP17429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="65" mass="7830" checksum="E47B3B1E0DD2F44D" modified="2014-10-01" version="1">MKKHEIFFSLSFAPYLWSSIPERRECFEHPKALPRIRTDDFLSLFLKGESLTLWTRYLCYLISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VA61</accession>
    <name>A0A068VA61_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00000937001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the plant 'ANKYRIN-BTB/POZ' family. 'NPR1-like' subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG739244">
        <property type="protein sequence ID" value="CDP17457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VA61"/>
    <dbReference type="FunCoup" id="A0A068VA61">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VA61"/>
    <dbReference type="Gramene" id="CDP17457">
        <property type="protein sequence ID" value="CDP17457"/>
        <property type="gene ID" value="GSCOC_T00000937001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VA61"/>
    <dbReference type="OMA" id="QFFHEKF"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VA61"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000022">
        <property type="term" value="P:regulation of jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000031">
        <property type="term" value="P:regulation of salicylic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009862">
        <property type="term" value="P:systemic acquired resistance, salicylic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18310">
        <property type="entry name" value="BTB_POZ_NPR_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000110">
        <property type="entry name" value="Regulatory protein NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000123">
        <property type="entry name" value="regulatory protein NPR3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044292">
        <property type="entry name" value="NPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021094">
        <property type="entry name" value="NPR1/NIM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024228">
        <property type="entry name" value="NPR_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057250">
        <property type="entry name" value="Znf_C2HC_NPR-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46475">
        <property type="entry name" value="REGULATORY PROTEIN NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46475:SF9">
        <property type="entry name" value="REGULATORY PROTEIN NPR3-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11900">
        <property type="entry name" value="DUF3420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12313">
        <property type="entry name" value="NPR1_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52046">
        <property type="entry name" value="ZF_C2HC_NPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC NPR-type" evidence="15">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="590" mass="65698" checksum="5270E83B7FD85004" modified="2014-10-01" version="1">MESGNELVSTLSFASSSYTSNGSSSHNMPSAGHEPGASLDLLTLTKLSGSLEKLLLDAEFDYSDAEIVVEGTSVGVNRCILASRSPFFHDLFKKSNAGSANGTKPNYVMTELVPRGKIGYETFMVFLNYVYSGKLKSSPTEVSTCVDESCAHDACGPAINYAVELMYASATFQMNELVLVVQRRLLNFVDKAFVEDVIPITIVAFHCKLNQLLSHSIQRIARSDLDDLTLEKELPHEVLTDIKSFRKQYDQDLQHDNGEVNFITDKRIRRIHKALDSDDVELLRLLLAESDITLDAAFGLHYAAAYCNPKVVTEVLSLGNANLNLRNSRGYTVLHVAARRKDPSVIVGLLSKGACVSDSTDDGRTSITICRRLTRPKDYNESTKQGQETNKDKLCIDVLEREMLRNPLAGNMSMSSMMVADDLVMRLLLLENRVALARVLFPREAKLAMEIANAHSTSEFAGLAASKASCGNLREVDLNEIPYEQVKRLQLRLQALQKTVETGRRFFPNCSEVLDRFLEDDMQETLLLENGPLEEHSTKKMRYMELKDEVLKAFDKDKAENNWVGLSSSSSCSSSPKAIAHHKAKKRQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBU4</accession>
    <name>A0A068VBU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00003115001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739286">
        <property type="protein sequence ID" value="CDP18062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBU4"/>
    <dbReference type="Gramene" id="CDP18062">
        <property type="protein sequence ID" value="CDP18062"/>
        <property type="gene ID" value="GSCOC_T00003115001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBU4"/>
    <dbReference type="OMA" id="YVHIHIT"/>
    <dbReference type="OrthoDB" id="688325at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VBU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328">
        <property type="entry name" value="FAR-RED IMPAIRED RESPONSIVE (FAR1) FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46328:SF34">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="94" mass="11107" checksum="F39EC14A4650EA78" modified="2014-10-01" version="1">MDCSKLTEDKIPELGMEFNSKEDAYKFYNKYAFKMSFSVRKDYLNKDKDGVITSRRYSCCKKCVKRKYEDDAMPKRTRAPTKTGYETKMIIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VEC5</accession>
    <name>A0A068VEC5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00001632001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739283">
        <property type="protein sequence ID" value="CDP18048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VEC5"/>
    <dbReference type="STRING" id="49390.A0A068VEC5"/>
    <dbReference type="Gramene" id="CDP18048">
        <property type="protein sequence ID" value="CDP18048"/>
        <property type="gene ID" value="GSCOC_T00001632001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VEC5"/>
    <dbReference type="OMA" id="PANFITN"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VEC5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF45">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="128" mass="14415" checksum="883613E8180A8AD3" modified="2014-10-01" version="1">MNEMKKAELVFIPSPEMGHLVSSVELAKLLIEREEQLSITVLIMKPPFDTNIINYRNSLSASLSSRIRFLELIKEEPSSQLTFSHSFLFQFIDSHKSCVKEVLAKISNSVSSDLSGIVIDMFCTSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VI67</accession>
    <name>A0A068VI67_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH200=94 genomic scaffold, scaffold_1181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00004718001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG740265">
        <property type="protein sequence ID" value="CDP20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VI67"/>
    <dbReference type="STRING" id="49390.A0A068VI67"/>
    <dbReference type="Gramene" id="CDP20411">
        <property type="protein sequence ID" value="CDP20411"/>
        <property type="gene ID" value="GSCOC_T00004718001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VI67"/>
    <dbReference type="PhylomeDB" id="A0A068VI67"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF137">
        <property type="entry name" value="MYROSINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="222" mass="25196" checksum="89E74E44856A2D86" modified="2014-10-01" version="1">MSIYFCFCFISVFQYEGAHDADGRGASIWDTFLKENYPVLFDFTNTVAINGLNAEDKKIMKEMGFNTFRLSISWPRVLPYGRRTYGPNGEEQGVNKKGIDFYNNVINLLLENGNFLIQPIFLFALFEALKLTFIDLKSCICTKDFIDYTDPCFREFGDRVKLWLTFNETWTYSLLGYMVGSFAPSRGATLARCLAPRAGDPTTEPYIVTQLALVSCSGSEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VKC7</accession>
    <name>A0A068VKC7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_2426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00008185001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG741510">
        <property type="protein sequence ID" value="CDP21072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068VKC7">
        <property type="interactions" value="2507"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VKC7"/>
    <dbReference type="Gramene" id="CDP21072">
        <property type="protein sequence ID" value="CDP21072"/>
        <property type="gene ID" value="GSCOC_T00008185001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VKC7"/>
    <dbReference type="OMA" id="WIGMISN"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VKC7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="1">
        <location>
            <begin position="824"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1629" mass="184595" checksum="71BBAE9418E93BB0" modified="2014-10-01" version="1">MQELNTAEDFISFYQEMFPLVQTLPQIILQKELIVSKLLSRLQIKSRLSLEPILRLVATLSRDLLEDFLPFLQRIVNAIVFLLKNGGDKDPDIIKQIFTSWSYIMMFLQKYLIKDVIHVLKVTVKLRYYPHGSIQKFVAESVSFLLRNAPVEQLIKAGVRKIMIEVVKNPLAKRKSGATELLWHVIRGSSSTLHSRAPQVLQLLLDKSLFSIGDQLLEDPDCLLEIVISTFQRLSNEAGPVELNLIWDCLYGEIIESVTNGHSMHVSRLLSVLVLIVENGFMKKISDYQPMFKLVRLLVQTYVPPVTEEGGKQATDIVIKILQLSLFIVDGLHKANDLSALSDFSCQLVPIFSLKNPGLLTFLKDLVSRDSNVLKIFRINIISALNDLTNISEEETVYCWLRLCENLKMPSFSFLDGISKDKLSRIYDLVQQSISYWIGMISNSLHGDLSSLQLEQSRLALLWGTVKCYPYLFNGQENLTLLLDLLNAIDELLMTESGLADLTWQSLIGATLGSYKEMLSSSGTGCEESAISKFLYLAKKYHSSSQILAPIADILDSHFGSVIKGCTSFRRYHPDLAARNVIDALDILAENLCNCDQMLRRSTLRILCHYEPLKFESSFNTQPDEKTAGNDIMQTFNVLELLLSVETTEPSSTDRKIELLLSRIQVNVSARKIDENYVPALLYGLIGIFHIRLSNLWIPAKECLAVLISQNFGIVWEPYMKYLDHCQSLFLISCDQSSRSGTKSLNQSSDLVGYFNLSINPPCGSTPCATLFSLMIQSLQKVPFLAETRSRQLMPFFLKFLGYSVDDLLSVELYNVHCCKGREWKEALKELLNLFRLLRNPKSFYQSQFIKDVFLYRLLDETDTELQLKVLDCLLNWKDEFLLPYSQHLKDLINAKNLREELTTWSLSRESNEIDEHHRDFIVPIVIRILVPKVKKLKTLASRKHASVHQRRAILGFLAELDIQELPLFFFLLIKPLQGRQCLLSSSESVKDEFDSISILKEFTVDGLKGLSWKKKFGFLHVIEEILAVFDEYHINPFLNLLMGCVVRVLESCTAALESSKCKEPSLTDSGFNVAAAYDIVDREIDTSTAVKQFKELRSLCLKIVSSALAKYENHDFHSEFWDLFFTAASPLIGSFKQEGASSEKPSSLFSCFLAMSRSIKFVPLLGRKKNLVPDIFSMFTITTASDAIISCVFKFVENLLNLDSQLGTEDGSVKRVLLPHLNVLVDSLHCLFTIASGTKRHPADNELFVFKLLSKYITEPLTAKKFVDILLPLLAKRLRNSDSCVVILQILQSVVEVVGSENNSKILSSVSPLLTFAGLDVRKSICDVLNALAKDDSSVFVVAKLLNEMNATSAMDIGSLDYDTIIGAYEKINGEFFHTVGKEHALIILSQSAYDMSSEELIFRQSAYRLLLCFVEFASEIVESKDKSDQGCWTEALIQHIVTSFLLKHMGNAMNRETSVQKLWIDLLREMVLKLPKVANLESYGTLYSQDPEQDFFNNVIHLQKHRRARALSRFSQFISTGNHSEVVSTKVFIPLFFNLLFGVQEGKGENVRSACMEAIASIAGCMTWKQYYELLMNCFREMTKREKQKVILRLICCILDHFHFSETPAEGVLRSGAVDCMTCMVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLF2</accession>
    <name>A0A068VLF2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_4099</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00011085001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG743183">
        <property type="protein sequence ID" value="CDP21434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLF2"/>
    <dbReference type="Gramene" id="CDP21434">
        <property type="protein sequence ID" value="CDP21434"/>
        <property type="gene ID" value="GSCOC_T00011085001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLF2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP21434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="30" mass="3564" checksum="3788407991DCF591" modified="2014-10-01" version="1" fragment="single">RFELRILMSIAACFMQDLSVEELCPRMTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLF8</accession>
    <name>A0A068VLF8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00010586001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DH200</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DH200</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG743814">
        <property type="protein sequence ID" value="CDP21536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLF8"/>
    <dbReference type="FunCoup" id="A0A068VLF8">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLF8"/>
    <dbReference type="Gramene" id="CDP21536">
        <property type="protein sequence ID" value="CDP21536"/>
        <property type="gene ID" value="GSCOC_T00010586001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLF8"/>
    <dbReference type="OMA" id="VFLFYSE"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLF8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP21536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="106" mass="10737" checksum="B7C4CAB9E87A486F" modified="2014-10-01" version="1">MARGTSQSQAASGPTSRPGMVAPRGSAAATAVQRRRRLGGGSSNAGGSGTVGAGSSSNMLRFYTDDAPGLKISPTVVLVMSVCFIGFVTALHVFGKLYRYRSAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLU4</accession>
    <name>A0A068VLU4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH200=94 genomic scaffold, scaffold_1479</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00010401001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG740563">
        <property type="protein sequence ID" value="CDP20648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLU4"/>
    <dbReference type="FunCoup" id="A0A068VLU4">
        <property type="interactions" value="1392"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VLU4"/>
    <dbReference type="Gramene" id="CDP20648">
        <property type="protein sequence ID" value="CDP20648"/>
        <property type="gene ID" value="GSCOC_T00010401001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLU4"/>
    <dbReference type="OMA" id="CEAKQVA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLU4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP20648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="367" mass="41076" checksum="7C069CC27B37B69A" modified="2014-10-01" version="1">MGNVVDVQNVLKKKRKLGVAPRSNDYGQFIFALISERLVCEAKQVAQVIISGNFPLEEDALNALIGSVSTVDPYCAVSFLNFMLDKEGLPTLLTLTNLGRNLCKHGRSSELVEVFQVLSAKEYFVDTQSYNVIITFLCKAGRIKEAYQALQEMKKKGLVPDVSCYNALLEACCREDLLRPAKRLWDEMFTNCCNGNVQTYSIFIQKFVEIGEIDEAHRLFCCMFEKGVAPDVTIYTTLLGGLCRAKHLDTAVRVFNKSAEQDMKLGQTTLIAFILFLCKEGLYVPTSKLLTSCICGIENLEAHMTFLKFLADAGEVSLASEHLEQIGDKSPLMLHALHTDIMSFSSSPKLKPIVKLFQQLQENHQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VM64</accession>
    <name>A0A068VM64_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH200=94 genomic scaffold, scaffold_7558</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00006562001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sodium/anion cotransporter (TC 2.A.1.14) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG746642">
        <property type="protein sequence ID" value="CDP21895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VM64"/>
    <dbReference type="STRING" id="49390.A0A068VM64"/>
    <dbReference type="Gramene" id="CDP21895">
        <property type="protein sequence ID" value="CDP21895"/>
        <property type="gene ID" value="GSCOC_T00006562001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VM64"/>
    <dbReference type="PhylomeDB" id="A0A068VM64"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF243">
        <property type="entry name" value="ANION TRANSPORTER 6, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP21895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="267" mass="29801" checksum="48525C69286CE886" modified="2014-10-01" version="1">MSKRTKNAMVVGKFDTLSGASLPRQIENMEASQHSLYLFKFCGKYGVKREAFGNLGMQRLWEGKAQYTLNTSSAVTVRSIIQRLREQIGWIQKPVKANNIVLDSNRKSFQYPGHLFFSEKNSWIGSLEELEGSLKDVPWKAFFKSKAVWAMIYAHFCGSWGHYTCLSWLPTYFSEELSLNLTEAAWVSVLPPLASIFVTSIAAQLADYLITKGVDTTRVRKTCQTISFLSPTSCMILSSLDLGLPPWEVVTILTGGLALSSFALSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMF7</accession>
    <name>A0A068VMF7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00012613001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="HG747645">
        <property type="protein sequence ID" value="CDP21975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMF7"/>
    <dbReference type="FunCoup" id="A0A068VMF7">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VMF7"/>
    <dbReference type="Gramene" id="CDP21975">
        <property type="protein sequence ID" value="CDP21975"/>
        <property type="gene ID" value="GSCOC_T00012613001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMF7"/>
    <dbReference type="OMA" id="HPKINDI"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMF7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP21975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="198" mass="22929" checksum="92EA8DA57741AC3F" modified="2014-10-01" version="1">MLVSLQRKWNFTPKSDTVAITNYQNMLFNRHSIISTLVLYIEIDSVQIEYDPKLITFKQLLEVFWTSHDSRQVFGQGPDVGNQYRSIVFTNGTEESRLASVSKEREQTRSKSGIVTTQIQQLGTFYPAEPDHQKFELKRHPFLLQLMGNLPEEELEKSSLAAKLNGYAAELCPPRLQKRIHPKINDILRKGWPILREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNX9</accession>
    <name>A0A068VNX9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DH200=94 genomic scaffold, scaffold_3953</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSCOC_T00006543001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG743037">
        <property type="protein sequence ID" value="CDP21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNX9"/>
    <dbReference type="STRING" id="49390.A0A068VNX9"/>
    <dbReference type="Gramene" id="CDP21418">
        <property type="protein sequence ID" value="CDP21418"/>
        <property type="gene ID" value="GSCOC_T00006543001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNX9"/>
    <dbReference type="OMA" id="MESRIYI"/>
    <dbReference type="OrthoDB" id="544400at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNX9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000590">
        <property type="entry name" value="PR5-like receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="405"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="682"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDP21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="732" mass="83199" checksum="55D4A75381D29ECE" modified="2014-10-01" version="1">MYQMSLSLWKKYWSFLLVSLLEEELIAKKVLNWWVMSYDLINYRENIKKTVSSDSSLSIASLLVLVLVLAGLATSCEATNNHHCNPSSCGDIRNISYPFRLKEDPIHCGDPSYELACENNRTIVNLFLQKYYVQEIIYEKYLMRVVDPGLDEANCSSFPINTLEYDELQMADNPQDAYDIFYTNIPVLFISCPAPVRSPFFSDIMAFCRNHMSSNFSSPTNNHSYLLFGNHEVSVLNDSCAVNMAAWITKDFGGRKAYTSPAGLYDALAYGFLLDWRGIYCQQCSSGFCDRDVNDSIRCSPKYWQCELLHPSTFRPTFECLKEIWYQKVEFLNQNTAISRELGILIGMCLAGRFLLGVPFLFALIIYKIRRSHLSMYENIEDFLQSPNNLLPVRYAYSDIRKMTNNFNDKLGEGGYGTVFKGKLRSGPLVAVKMLGKSKANGQEFISEVATIGRIHHANVVRLIGFCFEGSKRALVYEFMPNGSLEKYIFRKETETTSLSCEKLFNIALGIAKGIDYLHRGCEMQILHFDIKPHNILLDEHFAPKLSDFGLAKLYPTENSIVSLTAARGTLGYMAPELYYKNIGGVSYKADVYSFGMLLLEMAGKRKNLNPLVDQRSQIYFPSWVYDQLSKGNSIEMGDASEDERKMLKKMILVALWCIQMKPINRPSMNKVIEMLEGDGELLEMPPKPFQNPDEMPAPEAEDGGNDAEETANFPLLSLDRVDSSDMSMDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VPX0</accession>
    <name>A0A068VPX0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DH200=94 genomic scaffold, scaffold_6520</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00006455001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG745604">
        <property type="protein sequence ID" value="CDP21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VPX0"/>
    <dbReference type="STRING" id="49390.A0A068VPX0"/>
    <dbReference type="Gramene" id="CDP21773">
        <property type="protein sequence ID" value="CDP21773"/>
        <property type="gene ID" value="GSCOC_T00006455001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VPX0"/>
    <dbReference type="OMA" id="VECLAVW"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VPX0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF47">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="286" mass="30845" checksum="CC1EAE3539E0503F" modified="2014-10-01" version="1">MRLVFVHGSTGPIPNEIGNLLKLESLDLRRNSLSGSIPVGIFNMSTLRELDLLGNHLSGVLPSNMCHGLHNLEDIVLSLNNFSGAIPASISNCCISLRQIDVGDNPLNGVLPKSIGNLSISVECLAVWNCGLRGNIPDSIGNLSNLVLLGLDDNSLTGSIPTAIWGLQKLRLECLGLSQNQISGSIPGCFNNLTSLWYLDIAFNRLTSTLPMRLWDLKGLVYVNLTSNLLRGPLAPEMGELKDLTKLDLSNNQFSGKIPSTIWSLESLDHLSLANNSLQGSIPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VQ22</accession>
    <name>A0A068VQ22_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF819 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00002390001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG746124">
        <property type="protein sequence ID" value="CDP21838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VQ22"/>
    <dbReference type="Gramene" id="CDP21838">
        <property type="protein sequence ID" value="CDP21838"/>
        <property type="gene ID" value="GSCOC_T00002390001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VQ22"/>
    <dbReference type="OMA" id="GSIAHMI"/>
    <dbReference type="OrthoDB" id="1725737at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VQ22"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008537">
        <property type="entry name" value="DUF819"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289:SF5">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN (DUF819)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF819)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05684">
        <property type="entry name" value="DUF819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="20722" checksum="55E6872E522C6035" modified="2014-10-01" version="1">MILFVTAIFVADATTDLPSDSASKLPVLQMGTSLAVSFAICKASTSLTRFFGIQNCDLPVITTIVVILATSFPGYFRPIAPTADAIAVVLMQVFFAVVGAGGSIWNVINTAPSIFMFAFVQVTVHLILILGLGKLFCVDLKLLLLASNANIGGPTTACGMAKAKAWDSLVVPGILAGIFGVSIATFLGIGFGILVLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLR0</accession>
    <name>A0A068TLR0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00014517001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLR0"/>
    <dbReference type="STRING" id="49390.A0A068TLR0"/>
    <dbReference type="Gramene" id="CDO97245">
        <property type="protein sequence ID" value="CDO97245"/>
        <property type="gene ID" value="GSCOC_T00014517001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLR0"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLR0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF129">
        <property type="entry name" value="PUMILIO HOMOLOG 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="282"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="450"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDO97245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="625" mass="69945" checksum="0E4DC7BB3A1D8BF1" modified="2014-10-01" version="1">MEERNQEDLEWLMARNPPPQSSPNAFGILPIPENPRTFSLPSPGNHVNRLSSLPASRSLHIPNPYHTNVALHNSANTNIHVNPNYADSFYDYLLEAEFNQLNLSTPRQTTAAAAAYGCHVGRLGSVPGKFGSIPVGSNTYVDDSSVGTAQFPLSYATTRYANNGNFQRMRIDSAVRGQLGMYIQPQYLTSVDDQVLNGNLRGSNLNNAFHDQEMDNLPRQGLVSVNRNASAFRPELGFVFPNNSGRNKINTTATLQRRERSLDGFDYDNPSLSTSFHSRCRQRGQSLSSLEELRSKIFSSLEDLRGKIFIVAKDQNGARDLQKMLAEGKPKEKEIIFSELKDHVRELMVDQFANYLAQKMFEIGNADQITELLLLVINDEHSLMAICLDMHGTRAMQKLLGHVTTPEQRSLVISALRRITVTLTKSNNGHHVVEHCLKYFPIEDKKYILDVVADNCLDIATDKSGCCVLQQCVEHARGEPRDRLIAEITANALVLSEHPYGNYVVQFIIGLRIPYITSDILSQLAGNYVSLSMNKYGSNVVEKCMKESSEEHAMQIIKEIIGSQNFLAVLQDPFGNYVAQSAFAIAKGSIRHAMINLIQMHYSYLHSHPHGKRVLARARGSKQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TM33</accession>
    <name>A0A068TM33_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00014253001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TM33"/>
    <dbReference type="FunCoup" id="A0A068TM33">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TM33"/>
    <dbReference type="Gramene" id="CDO97037">
        <property type="protein sequence ID" value="CDO97037"/>
        <property type="gene ID" value="GSCOC_T00014253001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TM33"/>
    <dbReference type="OMA" id="GNLHPWH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TM33"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF452">
        <property type="entry name" value="LACCASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005103923" description="Laccase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="166"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="413"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO97037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="566" mass="63258" checksum="E8468724513DD6FA" modified="2014-10-01" version="1">MGRRHCSFYLNCAFLFMCSIGWISLPPVNAALKQYQFDIQVKNVSRLCHAKPIVTVNGMFPGPTIYAREGDRVQINVTNYAQYNMSIHWHGLKQYRNGWADGPAYVTQCPIQTGQSYTYDFNVTGQRGTLWWHAHIFWLRATVYGAIVIMPKQGMAYPFPQPDFEFNLVLGEWWNDDVEEVVKQGNKLGLPPRMSDAHTINGKPGPLFPCSEKHTYAVEVEQGKKYLFRIINAALNDELFFAIAGHNMTVVEVDAVYTKPFSTDAILIAPGQTTNVLVHANKISSRYFMAARPFMDAPLPIDNKTATAILQYKGVPNNVLPSLPNLPAPNDTSFALSYSAKLRSLNSPQFPANVPLKVDRHLFYTIGLGMNPCPTCQNGTRLTASLNNITFIMPQIGLLQAHYFNLTGVFTTDFPDRPPTPFNYTGAPLTANLRTVRSTRPRLSRIAFNSTVELVLQDTNLLSVESHPIHLHGYNFFVVGTGIGNFDPKKDPAKYNLVDPPERNTIGVPTGGWTAIRFRADNPGVWFMHCHLELHTSWGLKTAFVVENGPGPDQTILPPPKDLPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TN40</accession>
    <name>A0A068TN40_COFCA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013885001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
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                <person name="Rouard M."/>
                <person name="Rozas J."/>
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                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
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                <person name="Nagai C."/>
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                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO96763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="61" mass="6933" checksum="9180333ADB9935A5" modified="2014-10-01" version="1">MYISFCLGWGFGQRTRSAGTSLPLRIHWGIVCGTMILQNVNIKTCMFQKFVTFLASLLMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPW9</accession>
    <name>A0A068TPW9_COFCA</name>
    <protein>
        <submittedName>
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        <lineage>
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            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
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                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="CDO98360">
        <property type="protein sequence ID" value="CDO98360"/>
        <property type="gene ID" value="GSCOC_T00022427001"/>
    </dbReference>
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        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="69" mass="7309" checksum="F1750A901CE91E6C" modified="2014-10-01" version="1">MSSGMSETRVLKPNSSNNLIGFILPIPIGGQTTHSKAQQITPNATVSYWLPMPNLQSSSINCSTGDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQP1</accession>
    <name>A0A068TQP1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Photosynthetic NDH subunit of subcomplex B 1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00022255001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
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            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQP1"/>
    <dbReference type="FunCoup" id="A0A068TQP1">
        <property type="interactions" value="1364"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQP1"/>
    <dbReference type="Gramene" id="CDO98229">
        <property type="protein sequence ID" value="CDO98229"/>
        <property type="gene ID" value="GSCOC_T00022255001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQP1"/>
    <dbReference type="OMA" id="PLEHWAE"/>
    <dbReference type="OrthoDB" id="1932779at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQP1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010598">
        <property type="term" value="C:NAD(P)H dehydrogenase complex (plastoquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044983">
        <property type="entry name" value="PNSB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37698">
        <property type="entry name" value="PHOTOSYNTHETIC NDH SUBUNIT OF SUBCOMPLEX B 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37698:SF1">
        <property type="entry name" value="PHOTOSYNTHETIC NDH SUBUNIT OF SUBCOMPLEX B 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO98229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51199" checksum="F02C049C47528D1C" modified="2014-10-01" version="1">MAATSLLPKSISQFLINPPSIPSTSLINATFVNNSADLIFCTKNSCKIVTNAKKNPWLDPFDDGVDPEMEYGSLFSEGKQEEDPRPPDNPDNPYGFLKFPMGYNVEIASLGLKIRGDVRRCCCVISGGVYENLLFFPAIQLLKDRYPGVQIDIMASDRGKQTYELNKNVRWANVYDPDDDFPEPAEYTDILGVLKNRYYDMILSTKLAGIGHAAFLFMSTARDRVSYVYPNVNAAGAGLFLSETFKPDSANLSEGGYHMYHQMVDWLGRPGRKVPRHPVPPLKVLISRKLKEVVEAKYQKAGVQKGKYIVIHGIKADSKANMQSRGDADSLLPIEVWSQITNAINGLRPVFVIPHERERENVEDVVGYDASMVFITTPGQLAALINDSAGVIATNTAAIQLANAREKPSIGLFSSEDKGRLFVPNAEAKKCSIISSKTGRLIDIDVEAVKSAVEIFTVPLALASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQU6</accession>
    <name>A0A068TQU6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein SCD2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00022370001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQU6"/>
    <dbReference type="FunCoup" id="A0A068TQU6">
        <property type="interactions" value="1981"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQU6"/>
    <dbReference type="Gramene" id="CDO98314">
        <property type="protein sequence ID" value="CDO98314"/>
        <property type="gene ID" value="GSCOC_T00022370001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQU6"/>
    <dbReference type="OMA" id="GPKHEHW"/>
    <dbReference type="OrthoDB" id="2014962at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQU6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000911">
        <property type="term" value="P:cytokinesis by cell plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040321">
        <property type="entry name" value="SCD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31762:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN SCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31762">
        <property type="entry name" value="FAS-BINDING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO98314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63405" checksum="AA9B9C8ED24E0251" modified="2014-10-01" version="1">MDRRTTESLVYARQWSGGSSSTGSSSPAGSPAHPRSRLPPATGGMSTIKRTQNVAAKAAAQRLAQVMASQVTADDDDDDDDDLGFRFAGAPPPASGFSSNVNSSRVDRNSHSGFPAASLAKPNRSPSPALGRNFMDHTPSVRSTSAGRPSMSVRSTTTTVLPQNKTTLRTPVTIPPIEPPSSRLREKRLTPDVGLVDLKASGNEHEASALRDELDMIQEENELILDKLRHAEEKHEEAEARARELEKQVAALGDGVSLEAKLLSRKEAAIRQREAALKAAQQTKDGRDEQISSLRAEIENLKDETVNTMEQLREAESEAKALRVMTQRMILTHEEMEEVVLKRCWLARYWGLAVHYGICTDVAALKHEHWSSLAPLPFEVVISAGQKAREESRNGGDDTERRNKHVRNLSDLTGEGNIESMLSVEMGLRELASLKVEDAVVLALAQHRRSSLVRHSFLEPKSTIETKYMEPFELSQEESQDVLFKEAWLAYFWRRAKDHGVEEDIADERLQFWISRSAQSPTSHDAVDVERGLTELRKLGIEQQLWEASRRELEQQSIPTLMPGVESDNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TQX4</accession>
    <name>A0A068TQX4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purple acid phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00022810001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="11">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="10"/>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO98646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TQX4"/>
    <dbReference type="FunCoup" id="A0A068TQX4">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TQX4"/>
    <dbReference type="Gramene" id="CDO98646">
        <property type="protein sequence ID" value="CDO98646"/>
        <property type="gene ID" value="GSCOC_T00022810001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TQX4"/>
    <dbReference type="OMA" id="GFCIHEL"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TQX4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000027">
        <property type="entry name" value="Purple acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001657245" description="Purple acid phosphatase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="44"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO98646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="37843" checksum="E6BEA3AACC6D5226" modified="2014-10-01" version="1">MASFRNKSMVLCLWLATSFGLVYESVLAELQRFEHPTKGDGTLSFLVVGDWGRQGDYNQSAVARQMGIVGEKLDVDFLVSTGDNFYDDGLTGEHDPAFVDSFVNIYKARSLQKQWYSVLGNHDYRGDVEAQLSPSLRKIDSRWICLRSFIVNAEIAELFFVDTTPFVKEYFYEPKNHEYDWRGVTPPKTYTRNVLKDLQSALRESTAKWKIVVGHHAIRSVGHHGDTKELVERLLPILRANNVDFYVNGHDHCLEHISDDKSPIQFLTSGAGSKAWRGDLKEMKGDGLKYFYDGQGFMSVKLTQTHLEIAFYDVLGTVVHKWTMSKQLHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TST3</accession>
    <name>A0A068TST3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00026388001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TST3"/>
    <dbReference type="STRING" id="49390.A0A068TST3"/>
    <dbReference type="Gramene" id="CDO99291">
        <property type="protein sequence ID" value="CDO99291"/>
        <property type="gene ID" value="GSCOC_T00026388001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TST3"/>
    <dbReference type="OMA" id="KETAYRH"/>
    <dbReference type="PhylomeDB" id="A0A068TST3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013187">
        <property type="entry name" value="F-box-assoc_dom_typ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08268">
        <property type="entry name" value="FBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="360" mass="40872" checksum="37E4D4740C3B9E2B" modified="2014-10-01" version="1">MAHVHIPEEIIVEILSRLPVKSILKFKLVCKLWNSLLSDPRFSLATKGRERAIFWCSGKRCFSSLDHQYAIREIPRQCWDQRHLDFLGSCNGLVLFSTYDTSYDCYSCCYFYLLNPSTRSFRGLINFSSRMLYGENRITDNPVAYGFCFDKLSDDYKAIMVYYSSSSFPSQRALVFSLKRGTTLREVSLPYRLRGTGVLANGNLHWIDKNNQEIIGGDLIVCFDEATNRFSKLPPPAVVRGGNEPIYRLGVLDGCLCMSRYTAGSYTFKCELFVMREYGVKESWATLCAISGGANLRSVRGWEPLFFTKSGEELLISGSYSILAYNLQTKSLKEIHTYSGQGSYVGPLRYVESLIPAAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTN5</accession>
    <name>A0A068TTN5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00026586001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TTN5"/>
    <dbReference type="STRING" id="49390.A0A068TTN5"/>
    <dbReference type="Gramene" id="CDO99417">
        <property type="protein sequence ID" value="CDO99417"/>
        <property type="gene ID" value="GSCOC_T00026586001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTN5"/>
    <dbReference type="OMA" id="YINPENC"/>
    <dbReference type="OrthoDB" id="1879545at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTN5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF19">
        <property type="entry name" value="BET V I_MAJOR LATEX PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="3">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO99417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="155" mass="17310" checksum="0BAC3CD8B7ADF862" modified="2014-10-01" version="1">MFGRLCEEIEIKVAANEAWKIFGALELGHLAFQQLSDIIHKMEVLEGDGGAGTVIKLSLPGNTYCKEILKVVDQEKRVKIAELIEGGFLDMGFTFYQVRIEVIENAKDENSCTVKFTIEYEVKEDAAANASLVSIRPYVTMMNVGVDYLAKNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TTR7</accession>
    <name>A0A068TTR7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00026503001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739087">
        <property type="protein sequence ID" value="CDO99364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068TTR7"/>
    <dbReference type="MEROPS" id="S41.002"/>
    <dbReference type="Gramene" id="CDO99364">
        <property type="protein sequence ID" value="CDO99364"/>
        <property type="gene ID" value="GSCOC_T00026503001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TTR7"/>
    <dbReference type="OMA" id="PDVQCMP"/>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TTR7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.44:FF:000010">
        <property type="entry name" value="Carboxyl-terminal-processing peptidase 1 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000043">
        <property type="entry name" value="carboxyl-terminal-processing peptidase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.44">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060:SF7">
        <property type="entry name" value="CARBOXYL-TERMINAL-PROCESSING PEPTIDASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAIL-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Tail specific protease" evidence="4">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="254" mass="27358" checksum="77FE7EA6A8018443" modified="2014-10-01" version="1">MTIYDAAEHLQGPEGTGVDLTVRQGSEIRNVPLIRERVSLNPVKSKICKTPGMGKDGARVGYIKLTSFNQNASGAVKEAIETLRKDNVSAFVLDLRDNSGGLFPEGIEIAKIWLDKGVIVYICDSRGVRDIYDTDGSNAVAASEPLVVLVNKGTASASEILAGALKDNKRATLFGEQTFGKGKIQSVFELSDGSGLAVTVARYETPAHTDIDKVGIIPDYRLPASFPRDDESFCGCLQDPVSACYLDKVKLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVK9</accession>
    <name>A0A068TVK9_COFCA</name>
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        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP00271"/>
        <property type="gene ID" value="GSCOC_T00032158001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVK9"/>
    <dbReference type="OMA" id="MSARFTN"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVK9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF413">
        <property type="entry name" value="THIOREDOXIN H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="120" mass="13875" checksum="1A0EF4663F3EB6BD" modified="2014-10-01" version="1">MGAYWSTGANRSKVIEIHSTKKWRVHYEESKGTDKLMVIDFSASWCGPCGYMEPIVKEFSTTYTDVVFFKIDVDELADVAKEFGVQAMPTFVFMKNGKEVDKLVGADREELERMIHKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWF9</accession>
    <name>A0A068TWF9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00032308001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TWF9"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TWF9"/>
    <dbReference type="Gramene" id="CDP00382">
        <property type="protein sequence ID" value="CDP00382"/>
        <property type="gene ID" value="GSCOC_T00032308001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TWF9"/>
    <dbReference type="OMA" id="FYMYCKA"/>
    <dbReference type="OrthoDB" id="1934322at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133:SF7">
        <property type="entry name" value="F26K24.10 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133">
        <property type="entry name" value="OS08G0107100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP00382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="332" mass="36973" checksum="9C21D7F159ED764F" modified="2014-10-01" version="1">MSTTNSQILNLWGVLSESKRIINAHSRHFLALSVIFLLPLSFSLIIYPTLQSTFLSSDSLIPQQSLFISSPYASPHPTTAQFLLPLVYTLFVLLLSLLAVATITYSTFHGFYGRPVKLMSSFKSTLYSFLPLVSSFLVSQFIVALIISLLGLFAALIYKSLQLYGLDMDFDSKYFLGFSILVAIMVGLVLVWLQVNWSLGSVVVVVESKWGFEPLQRSYYLLSGMKRVALSMLLFYGLAIGLLVWGCSTSVANAGQASGWWRWTFVLQTVVSSAFITLLMLHNVAANVVLYMYCKALHGELAFEIAEEFACQYVSLPFDCQKVPHIVSVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TX62</accession>
    <name>A0A068TX62_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00029683001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TX62"/>
    <dbReference type="FunCoup" id="A0A068TX62">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TX62"/>
    <dbReference type="Gramene" id="CDO99953">
        <property type="protein sequence ID" value="CDO99953"/>
        <property type="gene ID" value="GSCOC_T00029683001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TX62"/>
    <dbReference type="OMA" id="GSNHRYA"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TX62"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO99953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="316" mass="35916" checksum="0427F66303CD8996" modified="2014-10-01" version="1">MGQGEEARKDESNVEIVERGEIFFFYRAKVNKEEAHSPDDVQRLYIVLRPESGEKSVEEKQGSSSGKEGAKMHESGNDEKETRPGGEGGRGDEKVDIEQQPLLRFIVMGKKSLPEPSQQRGRPYWGFVELVTTRIEDVKAALKGEEYDTNTRGHRRTEPARALAEGVYRILRHSPRKRMHTHLVYRLEFPPEDEKNEAQESLNDEREGSFLIQIKNPEQQGTSRFAGLQSKRKATFPAHLQGQFGNRRFNPADPPDFLNYEGCEFLLIAASDDIEEELGLELRTEVENSHDPSCSDLVRTFGETASIEPLLEGTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TXU5</accession>
    <name>A0A068TXU5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSCOC_T00032771001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TXU5"/>
    <dbReference type="STRING" id="49390.A0A068TXU5"/>
    <dbReference type="Gramene" id="CDP00714">
        <property type="protein sequence ID" value="CDP00714"/>
        <property type="gene ID" value="GSCOC_T00032771001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TXU5"/>
    <dbReference type="OMA" id="HIREIWN"/>
    <dbReference type="OrthoDB" id="1434936at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TXU5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDP00714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="105" mass="12081" checksum="219E18A7C825E8C1" modified="2014-10-01" version="1">MEGKLIVVRKLYAYNLRADFSIIGQNLATYRFIAVDIEFPGTIFRSQKPYDIKKKGDKNYQLMKENVNSLKLIQLGLTLSDSSGKLPNLGTDSYFIWEFQSFEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TY51</accession>
    <name>A0A068TY51_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00032160001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="3"/>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TY51"/>
    <dbReference type="STRING" id="49390.A0A068TY51"/>
    <dbReference type="Gramene" id="CDP00273">
        <property type="protein sequence ID" value="CDP00273"/>
        <property type="gene ID" value="GSCOC_T00032160001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TY51"/>
    <dbReference type="OMA" id="ANNQMYG"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TY51"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF14">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="514"/>
            <end position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="789"/>
            <end position="792"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606329-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606329-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606329-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP00273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="891" mass="102427" checksum="1EB3F8CF7A8ED893" modified="2014-10-01" version="1">MESPVQLALAALLGASVMAISAFYIHKRSVDQVLDRLIKLRRKHLPSSTLRNHYNCHIVSDADEEDADYSAAAYSEECINRGRRDKLSTSFDNIDGIIGDGVEEEEKARVGLYRVWSSMPNVRTSNEWIDEEEKKALSNLLDHNLDIISSDLPPLRTQQRDAGDDQYVDHLGPQLMVGSIGRLVTPRSSAGYTVDSAGDSDEEETERTTMGATLLSYNKEININIPNLHMAPSNAENANYIQAQRCKEIAHESKANGNDEDAKVEKASMHTMRSSCTSTSKYLPVRATVHESLNIEEEEVLKMIRECLDLREKYVFREKVPPWTKVVQESATSDVKQNPFNSAPVEATAHHFKMEDGVVHVYANESDTEDLFPVANATSFFTDMHHILKVMSVGNVRSACHHRLRFLEEKFRLHLLVNADREFLAQKSAPHRDLYNIRKVDTHVHHSACMNQKHLLRFIKSKLKKEPDEVVIFRDGQYLTLKEVFESLDLTGYDLNVDLLDVHADKSTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAEVTKEVLSDLEASKYQMAEYRISIYGRKQSEWDQLASWFVNNALYSENAVWLIQLPRLYNVYRSMGTVTSFQTILDNVFIPLFEVTVDPRSHPHLHLFLMQVVGFDIVDDESKPERRPTKHMPKPAEWTNEFNPAFSYYAYYCYANLYTLNKLRESKGLPTIRFRPHCGEAGEIDHLAAGFLLCHNISHGINLRKSPVLQYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPVFFQRGLNVSLSTDDPLQIHLTKEPLVEEYSVAAKVWKLSSCDLCEIARNSVYQSGFSHVAKLHWLGSQYFRRGPEANDIHKTNVPNIRISFRYETWEEEMQHVYARKAKLPRDIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYB9</accession>
    <name>A0A068TYB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00034385001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYB9"/>
    <dbReference type="FunCoup" id="A0A068TYB9">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00929">
        <property type="protein sequence ID" value="CDP00929"/>
        <property type="gene ID" value="GSCOC_T00034385001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYB9"/>
    <dbReference type="OMA" id="GSECSMD"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000037">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000088">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF138">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 91C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP00929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53661" checksum="CC4DBE1588A7A679" modified="2014-10-01" version="1">MESSNVLHVVMFPWLAMGHLIPFFRLSKLLAGKGHKISFISTPRNLQRLPKIPQELASQIELVSIPLPEVDNLPKQGETSTDIPHEKDQFLKIAFDLLRSPIASFLENTRPKPDWIIHDYASHWLPEIAAQNGVSAAFFSLFTAAALSFLGRPSALLSGEDGRSTAEDFTVVPKWIPFPSNCAYRLHEVRKNIEDASGNESGASDFVRFAASIDRSDLVIFRTSVEFEPEWFNLVRELYQKPVVSLGVLPPSLDDDDELETDEKWQKIQNWLDKQTASKVVYVALGTEATISQKEVQDLAIGLEQSELPFFWVLRKPPGSKKDVTDMLPEGFRERINANGQGVVYTEWVPQVKILSHPAIGGYLTHCGWNSVIEALGFGRVLILFPVMNDQGLNARLLEGKKVGVEIPRAAEDGLFTSTAVAETLRYAVVSEEGEPMRANARQMTSLFGNGKRNQDYIDTFVRCLEERKISNFLASTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TYH2</accession>
    <name>A0A068TYH2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00034610001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TYH2"/>
    <dbReference type="FunCoup" id="A0A068TYH2">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TYH2"/>
    <dbReference type="Gramene" id="CDP01097">
        <property type="protein sequence ID" value="CDP01097"/>
        <property type="gene ID" value="GSCOC_T00034610001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TYH2"/>
    <dbReference type="OMA" id="KPGDAMK"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TYH2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14662">
        <property type="entry name" value="STKc_SnRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000237">
        <property type="entry name" value="Serine/threonine-protein kinase SAPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000085">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP01097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="336" mass="38057" checksum="BC116CBCD97A3A09" modified="2014-10-01" version="1">MEKYEIVKDIGSGNFGVAKLVRERWTKELFAVKFIERGQKIDEHVQREIMNHRSLKHPNIIRFKEVLLTPTHLAIVMEYAAGGELFARICNAGRFNEDEGRFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSIAPRVKICDFGYSKSAVFHSQPKSTVGTPAYIAPEVLSKKEYDGKLADVWSCGVTLYVMLVGAYPFEDPTDPKNFRKTIMRILTVHYSIPDYVRISVECRHLLSRIFVANPEKRINIAEIKRHPWFLQNLPVEVMEAGSLQSNDINTPAQSIEEVLAITQEARKLEVAKAGLLSLGSMDLDDLDDADLEEDTEASGDFVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZJ6</accession>
    <name>A0A068TZJ6_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00034974001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TZJ6"/>
    <dbReference type="Gramene" id="CDP01364">
        <property type="protein sequence ID" value="CDP01364"/>
        <property type="gene ID" value="GSCOC_T00034974001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZJ6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="74" mass="8444" checksum="B91FBE719D7DCBAA" modified="2014-10-01" version="1">MIPCKDGLKSYGESSGACFDLWQCQNDPWPLHLLDIPLVPYAELRLSLMPYWFDNLPSLLSTGFEVYICSQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TZK0</accession>
    <name>A0A068TZK0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein groES</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00032863001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Seems to function only as a co-chaperone, along with cpn60, and in certain cases is essential for the discharge of biologically active proteins from cpn60.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms stable complexes with CPN60 in the presence of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068TZK0">
        <property type="interactions" value="1674"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TZK0"/>
    <dbReference type="Gramene" id="CDP00783">
        <property type="protein sequence ID" value="CDP00783"/>
        <property type="gene ID" value="GSCOC_T00032863001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TZK0"/>
    <dbReference type="OMA" id="KVFYRQW"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TZK0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF37">
        <property type="entry name" value="GROES-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="97" mass="10500" checksum="CB1EAB5D288E1F55" modified="2014-10-01" version="1">MARRLIPTLNRVLIEKLVQPSKTTAGILLPEKSAKLNSGKVVAVGPGLKDKAGNTIPVAVKEGDTVLLPEYGGTQVKLGEKEYHLYRDEDILGILHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U0Y5</accession>
    <name>A0A068U0Y5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00034845001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP01258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U0Y5"/>
    <dbReference type="STRING" id="49390.A0A068U0Y5"/>
    <dbReference type="Gramene" id="CDP01258">
        <property type="protein sequence ID" value="CDP01258"/>
        <property type="gene ID" value="GSCOC_T00034845001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U0Y5"/>
    <dbReference type="PhylomeDB" id="A0A068U0Y5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP01258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14206" checksum="741FF2178F114945" modified="2014-10-01" version="1">MRGSENVAAEDSTTISDDGGATTVTYNDIEDSKEDEKAVDLPPNPAQHPPTQPQASPYQEGELVLAYHNQRVYPAKIMKVDLVLNEWRYSVHYPVSSTFLTPCSIYCQVTSLLLLHLFTWFINNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U1E3</accession>
    <name>A0A068U1E3_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00037196001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U1E3"/>
    <dbReference type="Gramene" id="CDP01994">
        <property type="protein sequence ID" value="CDP01994"/>
        <property type="gene ID" value="GSCOC_T00037196001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U1E3"/>
    <dbReference type="OMA" id="FQGFHAS"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U1E3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000009">
        <property type="entry name" value="Auxilin-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF87">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1230"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP01994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1419" mass="159051" checksum="E4CFB75BCCC833EE" modified="2014-10-01" version="1">MENLSHSFSKKSYGGNGFGMASHGHKSVYDDVFGGPPKFGMPTLAPRLEDYSEIFGGFHSARGSSIPILDLPVVEEAELCCDVQSSRFDYSEVFGGFNGLDVSVSFEDLVRKAYGGDDPSDDDDDDTWTPAHSNSLSDESDPSVCSERSHSLANANICNEASGIRQFDISYHKANQRSNDEVSNVTTHRAELCAMPGHTYAIDEMHASQKVEGSKLQEASDLKSSVDFGGGAAEDEQFKNNVSVPKKCAVGTSESHAYRVEKSDGHFFSQSRPFVTVNDINLRTKPSRLPPPSRPPPVFASDKPNSKLKASKTCGLEQEDDSWPSFYDVEVDGNSSMMASATLRDAMQKAQAKIRSAKESMEKKEVLQSSLKLHSQTDIKEEKLSKTFDSSKDDRVQEKSAKQDSGIKLLAEEERYKIKMNQELSDLVEREGSTDLAEKPAKRRYGKHSSSSNPVLYNSEGNFAWRQGTEYFEVFEAHIPLAFEHNRDDNVLFQMDLDEFKHSVATETTEQLGGGKEFKAAEIASKLEDQNITFEVVAETFGERLRSETTAGSSCQTQSGEKAHVGVSYCESEVSKGKMKMAKQHEDSRKIGNVTNNSGQMNTKADLHVSEVEAKSHLRGVSEGPDTDKIAMDVHARKPNDRRSRENFEMNYCAGLDKVGKQDGNEKGETNQDEKKKQQEEYHESQKDERKQKEVCGRKENQKLHKEVVKSEDAEKRLKGAAEHAENEKDFKKSFEKSENKKSQELDCLVEKDNGNLREASNLVDSDDFELTPSYDHEDGQSDACEPGKGEVKVEEVEEQEDNNNGSNMVFVEDVEDVSMVANASEKSIHVSEEAGKHEEFCGHAKDAEQSMRDDKDKQGNLDQVTNLPMERENIKAFGETGKLTDEMNAPFLPGKLDKNCGELETIQESFSYEENDFPTGAKDGELGLHQGAANLLVENKSHSFGKIQNELRCQKLEKGTVDVNNCPYLHEHGIDSNEAGTGIENSSLQEKEVSRRACDPEITAVASHEQGWRVKMNNGVQITINKESLKDNVRPCQPCMWADNVQVIGAGLSTVREDRENGCNAGQRCGQNVERKEKNLNETVAQEDDKIAERLQREREELLRKMEEEREREREREKDRMAVDKATLEARDRSYAEARGRAERAAVERPTAEVRQRAMSVAREKLEKASFEARERSVPDKASVEARIRAERAAVERATLEARQRAFEKAMADKVSFEARERVERSVSDKYSASSKTVEMRQSSSFHDLPDFQSQSAGTSNVLRYSYSTAHAGLEGESPQRCKARLERYRRTAERAAKALAEKNMRDLLAQREQAERNRLAESLDAEVKRWSSGKEGNLRALLSTLQYILGPDCGWQPIPLTEVITSAAVKKAYRKATLCVHPDKLQQRGASIQQKYICEKVFDLLKEAWNTFNSEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U212</accession>
    <name>A0A068U212_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ADP-ribosylation factor-like protein 8B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSCOC_T00036752001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">May play a role in lysosome motility. May play a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739091">
        <property type="protein sequence ID" value="CDP01638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U212"/>
    <dbReference type="FunCoup" id="A0A068U212">
        <property type="interactions" value="2343"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U212"/>
    <dbReference type="Gramene" id="CDP01638">
        <property type="protein sequence ID" value="CDP01638"/>
        <property type="gene ID" value="GSCOC_T00036752001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U212"/>
    <dbReference type="OMA" id="RFRSEWG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U212"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000441">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF12">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 14 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDP01638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20642" checksum="62317539D3CBB0FE" modified="2014-10-01" version="1">MGLWDSFLNWLRSLFFKQEMELSLIGLQNVGKTSLVNAVATGGYSEDMIPTVGFNMRKVTKGNVTIKLWDLGGQRRFRTMWERYCRGVSAILYVVDAADRDSVPIARSELHDLLKKPSLSGIPLLVLGNKIDKSEALSKQALVDQLGLDSITDREVCCYMISCKDSINIDVVIDWLIKHSKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3A0</accession>
    <name>A0A068U3A0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00041436001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP02986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3A0"/>
    <dbReference type="FunCoup" id="A0A068U3A0">
        <property type="interactions" value="2012"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3A0"/>
    <dbReference type="Gramene" id="CDP02986">
        <property type="protein sequence ID" value="CDP02986"/>
        <property type="gene ID" value="GSCOC_T00041436001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3A0"/>
    <dbReference type="OMA" id="DRVSMKR"/>
    <dbReference type="OrthoDB" id="600557at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3A0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010048">
        <property type="term" value="P:vernalization response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15521">
        <property type="entry name" value="PHD_VIN3_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058585">
        <property type="entry name" value="Fn3_VIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032881">
        <property type="entry name" value="Oberon-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044514">
        <property type="entry name" value="VIN3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056990">
        <property type="entry name" value="VIN3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286:SF2">
        <property type="entry name" value="VIN3-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286">
        <property type="entry name" value="VIN3-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23376">
        <property type="entry name" value="Fn3_VIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07227">
        <property type="entry name" value="PHD_Oberon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23380">
        <property type="entry name" value="VIN3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="340"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP02986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="728" mass="81228" checksum="3B19F8C4AE037605" modified="2014-10-01" version="1">MDSSYLEGLMLDPSKCSKLSMDEKRELVYALSKWSHGAPEMLQSWSRQEILEVLCAEMGKERKYTGLTKLKIIEQLLKIVSEKKSQEHAAAIDLEAGASSEVPQKTAKRQRKTDNPVRLPVTVNTVSTNNVIEDLENPVYCKNSACRARLFHDAAFCKRCSCCICRKYDDNKDPSLWLICSSEPPFQGVSCGMSCHLDCALRHERSGILKDKLDNRLDGSFYCVACGKVNDILGSWRKQLLIARDTRRVDILCYRVSLCRKILAGTKHYQKLYDIVDEAVNKLEADVGPLTGLPVKMARGIVNRLSSGPEVQRLCAFAIESLDTMLSERVPDMSDCKVMSAKLVTLEDVCTSSVTVTLKFEDSSLGNLVGYTLWHRKSDDLDYPTEPTCTLFAPNSKFYLSGLSPDTDYHLKVVSLDSNRELGMCEVSFQTAATETEATNPNSKDMEVGRSESPATNCSSLSNPSSVEDETNNVIPCSNEDETRGDNYHDHHNTLEKMVSTKVYNGYTDTIERGLTGETISLLDEEHSMGKICSAPNTDAVNLESKPSPDGQMMEDTSTENGSNTPRQTGLDCVPPAAEALLPITPCKLDKMKDGLQRSCRPKLIIKDLDIGSGKEEEPQAGSSSKKRRLERLDDESAAVDKDFEYYVKVIRWLECDGHIETGFRKKFLTWYSLRATPQEVRIVKVFVDTFIEDPDSLAGQLVDTFSDVISNKRSTTVPAGFCLKLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U3W2</accession>
    <name>A0A068U3W2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00039658001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U3W2"/>
    <dbReference type="FunCoup" id="A0A068U3W2">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U3W2"/>
    <dbReference type="Gramene" id="CDP02303">
        <property type="protein sequence ID" value="CDP02303"/>
        <property type="gene ID" value="GSCOC_T00039658001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U3W2"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U3W2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1780.10:FF:000006">
        <property type="entry name" value="Chaperone protein ClpB3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="84"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="494"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="977" mass="110269" checksum="EC8ABF3AB48F6DAF" modified="2014-10-01" version="1">MATTTSFAGVHFHIRPSNSTCRPSLVSQPAPVSINFLAKPKALKSLNSLKLKRKDAFLTRRSEKLGRSSRSFVVRCETSSGRITQQEFTDMAWQAIVSSPEVAKENKHQIVETEHLMKALLEQKNGLARRIFSKVGVDNTRLLDATDKFIQRQPKVLGESSGSMLGRDLEALIQRARDYKKEYGDSFMSVEHLVLGFVQDNRFGKQMFKDFQISRKALKDAIEAIRGRQKVIDQDPEGKYEALEKYGKDLTTMARAGKLDPVIGRDDEIRRCIQILSRRTKNNPVLIGEPGVGKTAISEGLAQRIVQGDVPQALMNRRLISLDMGALIAGAKYRGEFEDRLKAVLKEVTDSDGQIILFIDEIHTVVGAGATSGAMDAGNLLKPMLGRGELRCIGATTLDEYRKYIEKDPALERRFQQVYVDQPTVEDTISILRGLRERYELHHGVRISDSALVEAAILSDRYISGRFLPDKAIDLVDEAAAKLKMEITSKPTALDEINRAVLKLEMERLSLTNDTDKASKERLSRLEAELSLLKARQAELNEQWEHEKTVMTRIQSIKEEIDRVNLEIQQAEREYDLNRAAELKYGSLNSLQRQLEAAEKELDEYMKSGKSMLREEVTGDDIAEIVSKWTGIPVSKLKQSEREKLLHLEEELHKRVVGQDPAVRSVAEAIQRSRAGLSDPHRPIASFMFMGPTGVGKTELAKALASYMFNTEEALVRIDMSEYMEKHAVSRLVGAPPGYVGYEEGGQLTEVVRRRPYAVILFDEIEKAHSDVFNVFLQILDDGRVTDSQGRTVSFTNTVIIMTSNVGSQYILDTDDDALPKEMAYETIKQRVMEAARAVFRPEFMNRVDEYIVFQPLDRDQINSIVRLQLQRVRQRISDRKMKIHVTDAAIQLLGTLGYDPNYGARPVKRVIQQYVENELAKGILRGEFKDEDSVLIDTEVTAFANGQLPQQKLVFRKSESDSQAPAENRETFSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4A7</accession>
    <name>A0A068U4A7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00041878001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739093">
        <property type="protein sequence ID" value="CDP03331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4A7"/>
    <dbReference type="FunCoup" id="A0A068U4A7">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U4A7"/>
    <dbReference type="Gramene" id="CDP03331">
        <property type="protein sequence ID" value="CDP03331"/>
        <property type="gene ID" value="GSCOC_T00041878001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4A7"/>
    <dbReference type="OMA" id="ALMSCRE"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4A7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="242"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP03331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="479" mass="53412" checksum="611886C61DB1D6CE" modified="2014-10-01" version="1">MQKLKDQRSRSSKPTTIHGLAQSGDLIAFQKLLRDNPSLLNDRNPVMAQTPLHVSAGYNNVEIIKLLLDWAGPEKVELEAKNMYGETPLHMAAKNGCNGAAKMLLAHGASIEAKANNGMTPLHLAVWHSLRAEDYSTVKTLLEYNADCSAKDNEGLTPLNHLSQSHGSEKLREILHKHLEEQRKRKAIEACSETQAKMDALENELSNIVGLDELKVQLRKWAKGMLLDERRRALGLKVGARRAPHMAFLGNPGTGKTMVARVLGKLLHMVGILPTDRVTEVQRTDLVGEFVGHTGPKTRRKIQEAEGGILFVDEAYRLIPMQKADDKDYGVEALEEIMSVMDSGKVVVIFAGYSEPMKRVISSNEGFCRRVTKFFLFNDFSSEDLAKILHLRMTNQVENSLLYGFKLHPSCSIDAVAALIDRETTEKQRQEMNGGLVDPMLVNARENLDLRLSFDCIDTDELLTLRLEDLEAGLVLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U4I9</accession>
    <name>A0A068U4I9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 704C1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00015192001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739094">
        <property type="protein sequence ID" value="CDP03436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U4I9"/>
    <dbReference type="STRING" id="49390.A0A068U4I9"/>
    <dbReference type="Gramene" id="CDP03436">
        <property type="protein sequence ID" value="CDP03436"/>
        <property type="gene ID" value="GSCOC_T00015192001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U4I9"/>
    <dbReference type="OMA" id="PYGGVFM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U4I9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP03436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58758" checksum="E023C813FD9D4591" modified="2014-10-01" version="1">MASIEVLFNPTWIITAALAVALTACVLKSMRRGSREKKKYTPVGGTVFHMLLNFDRLHHYLTDLARKYKTFRMLNFSRCEVYTSDPANVEYILKTNFANYGRGPYHHSVLEDLLGDGIFTVDGEKWRNQRKTSSYEFSTKILRDFSSGVFRTNASKLARLVSEAVASNQTMDVQDLFMKSALDSVFKVVLGVELDSMCGTNEEGTRFSRCFDEASAITLYRYVDLPWKLKRFLNLGSEAKLRNNVKVIDEYVYKIIRSKTEQLHKSRDDWLMKKEDILSRFLENNETDPKYLKDIILSFIIAGKDTTASTLSWFFYMMCKHPHMQERIADEVVKATNVKGNPLTDELANSITEEALDKMQYLHAALTETLRLYPAVPLDGKFCFSDDTFPDGLSIRKGDTISYQPWAMGRMKFIWGEDAEDFRPERWLNENGVFQQESPFKFPAFQAGPRICLGKEFAYRQMKIFSAVLLGSFTFKLSDKQKVVKYKTMLTLHVDGGLHLQASPRWGDINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U504</accession>
    <name>A0A068U504_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040138001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U504"/>
    <dbReference type="FunCoup" id="A0A068U504">
        <property type="interactions" value="1464"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U504"/>
    <dbReference type="Gramene" id="CDP02673">
        <property type="protein sequence ID" value="CDP02673"/>
        <property type="gene ID" value="GSCOC_T00040138001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U504"/>
    <dbReference type="OMA" id="ANNGTGH"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U504"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF138">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="254"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="374" mass="40339" checksum="8D62BD097160C237" modified="2014-10-01" version="1">MSPPLLGIEGEGQGNVSVMASSKSVDCVSNNGLGLKERNYLGLSDSSEESTSMSTVSKEKKSSLNLKATDLRLGLPGSQSPERESELNLLSSDKFDEKPLFPLLPSKDGICSSIHKSVVSGNKRVFSDTIDEYSTVKASTFNERNWMFSAAGSNSETHQSIGQGKFSGKAGVSVLSSRSCGNEPSEVPSKPSVEGPHVANGSNQTNMNRPTNSSAPAAKAQVVGWPPIRSFRKNTLATTSKNNNEVDGKPSSGALFVKVSMAGAPYLRKVDLKTYSAYQELSSALEKMFSCFTLGQCGAEEVSGKEMLSETKLRDLLHGSEYVLTYEDKDGDWMLVGDVPWEMFIETCRKLKIMKGSDAIGLAPRSVEKCKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U562</accession>
    <name>A0A068U562_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040216001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U562"/>
    <dbReference type="FunCoup" id="A0A068U562">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U562"/>
    <dbReference type="Gramene" id="CDP02738">
        <property type="protein sequence ID" value="CDP02738"/>
        <property type="gene ID" value="GSCOC_T00040216001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U562"/>
    <dbReference type="OMA" id="HEKTSMQ"/>
    <dbReference type="OrthoDB" id="1745547at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U562"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36332">
        <property type="entry name" value="STRESS RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36332:SF1">
        <property type="entry name" value="STRESS RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP02738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="246" mass="27018" checksum="7F4C3F932443E535" modified="2014-10-01" version="1">MIKRRFYKLDHGDRDAPSESSSSSDSELEAEATAETESEEEEEERGDNDDRIAEVRGGQAVSSSSGYESEDSSANELNLDSSGLPTSEDDGGSRNDGENILESHPSGDGNLEHHNSVPEVSDIPSDFADRVVKCKSVFKCKLCPRIVCLTEDSLKAHLKSKRHARSEKLLSEGRLKLMLDDDGKANGEVDPENNSSAQISPKTPGRAKRRHIHSKNFKKKKGKGSSLDHARQSAKNPAKKRFRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U5Y4</accession>
    <name>A0A068U5Y4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00016486001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="11"/>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP03970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U5Y4"/>
    <dbReference type="FunCoup" id="A0A068U5Y4">
        <property type="interactions" value="903"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP03970">
        <property type="protein sequence ID" value="CDP03970"/>
        <property type="gene ID" value="GSCOC_T00016486001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U5Y4"/>
    <dbReference type="OMA" id="GRFLHYW"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U5Y4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000001">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000143">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF254">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006512213" description="Carboxypeptidase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP03970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="498" mass="55698" checksum="806946F233A25296" modified="2014-10-01" version="1">MAGNAVVFRCFTLLLICVVVSFVRTQSAPETALITSIPGFNGTLPSKHYAGYVTVDESCGRKLYYYFVVSERNPSQDPVVLWLNGGPGCSSFDGFVYEHGPFNFEAGKTPDSLPTLHLNPYSWSKVSNIVYLDSPAGVGFSYSGNESDYITGDLKTASDSHTFLFKWFELYPEFLSNPFYIVGESYAGVYVPTLSYEVAKGIDEGVKPVLNFKGYMVGNGVTDDEFDGNALVPFAHGMGLISDDLYKEVISECRGNYYNPASDSCESKLEKVDEDLEGLNIYDILEPCYHGPATIKMVNGNTKLPVSFRMLGETERPLPVRTRMFGRAWPLRSPVRDGLVPTWPQLLKTTSVLCTNDEVATAWLNNEVVRQAIHAESVNVADTWELCTGRIQFHHDAGSMIKYHKNLTSKGYRALIFSGDHDMCVPFTGSQAWTRSVGYKIVDEWRPWIVNDQVAGFLQGYDYNLTFITIKGAGHTVAEYKPREALEFYTRWLDGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U7W0</accession>
    <name>A0A068U7W0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00017562001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739096">
        <property type="protein sequence ID" value="CDP04234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U7W0"/>
    <dbReference type="FunCoup" id="A0A068U7W0">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U7W0"/>
    <dbReference type="Gramene" id="CDP04234">
        <property type="protein sequence ID" value="CDP04234"/>
        <property type="gene ID" value="GSCOC_T00017562001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U7W0"/>
    <dbReference type="OMA" id="NFANFHN"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U7W0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001237">
        <property type="entry name" value="Dynamin-related protein 4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF173">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN 4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="63"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="580"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP04234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="75889" checksum="EE9B40D42443F21C" modified="2014-10-01" version="1">MSVLRDGSNVVSEGITRDLVQAVHDQEEMQAIQAPIVSSYNERIRPLLDCIDRLRNLKVMQEGIQLPTIVVVGDQSSGKSSVLESLAGISLPRGQGICTRVPLIMRLQSHPSPEPELSLEFNGKVVPTNEDHIAEAISVATDEIAGRSKGISNVPLTLIVKKNGVPDLTMVDLPGITRVPVHGQPEDIYEQISAIIMEYIKPEESIILNVLSATVDFSTCESIRMSQKVDKMGERTLAVVTKADKSPEGLLEKVMADDVNIGLGYVCVRNRIGDESYEEAQAVEATLFETHPLLSKIHKSMVGIPVLAQKLVQIQATIISKCLPDIVRKINDKLSTSVAELNKFPQQLKSVPEAVTAFMRIISSAKESLRKIFIRGEFDEYPDEKEMHCTARLAEMLSDYYEDLQLISIKVEQKQAFLEEEISILEEAKGISLPNFLPRKAFRTSLQKMVMAISATPAGFVNKFWEYLQGVLVPVLMKHSDNYPQLQPSIRRAAQNLVSKKREQSADWVSQIIEMEKLTDYTCNPEYSATWHDLMESQDRFMDIINDRCNDCTKSTLEINGIGEVEVGHLRNHLVVAQEAFDLKMRMTAYWKIVLRRLVDSMALHLLFSIQNLVNKDMETEMVNELMGTHGGALERMLEESPPIAGKRYRLNGSIKLLRESKEIVAEIMDKIAAYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U8Y0</accession>
    <name>A0A068U8Y0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00016613001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="4"/>
    <dbReference type="EMBL" id="HG739095">
        <property type="protein sequence ID" value="CDP04073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U8Y0"/>
    <dbReference type="FunCoup" id="A0A068U8Y0">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068U8Y0"/>
    <dbReference type="Gramene" id="CDP04073">
        <property type="protein sequence ID" value="CDP04073"/>
        <property type="gene ID" value="GSCOC_T00016613001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U8Y0"/>
    <dbReference type="OMA" id="ERDNICQ"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="PhylomeDB" id="A0A068U8Y0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF16">
        <property type="entry name" value="ALANINE-GLYOXYLATE AMINOTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP04073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="436" mass="47577" checksum="D932C416E4259543" modified="2014-10-01" version="1">MPPFDYTPPPYSGPSTEEILRKRQQYLSPAICHFYKKPLNLVDGKMQYLFDEKGRRYLDAFGGIATVCCGHCHPEVVDAIVNQTKRLQHSTVLYLNHAIADFAEALASKLPGDLKVVFFTNSGTEANELAMLLARLYTGYHDIISLRNSYHGNAAGTMGATAQSNYKFNVMQTGVHHALNPDQYRGIFGSDGPKYAKDVEDLITYGTCGCVAGFIAEAIQGVGGILELAPGYLPAVYSTIRKAGGLCIADEVQSGFARIGSHFWGFEGHGVVPDIVTMAKGIGNGIPIGAVVTTPEIANVLTRRNYFNTFGGNPMCTAGGLAVLRVIEKEKLQQNAFTVGSYLKERLTSLKGKHEIIGDVRGRGLMLGVELVQDRELKTPAKVETAHLMDEMKELGVLIGKGGFFGNVFRITPPLCFKKEDADYLVDVMDFVMSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068U986</accession>
    <name>A0A068U986_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00019590001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739098">
        <property type="protein sequence ID" value="CDP04842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068U986"/>
    <dbReference type="STRING" id="49390.A0A068U986"/>
    <dbReference type="Gramene" id="CDP04842">
        <property type="protein sequence ID" value="CDP04842"/>
        <property type="gene ID" value="GSCOC_T00019590001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068U986"/>
    <dbReference type="OMA" id="AIMADTF"/>
    <dbReference type="PhylomeDB" id="A0A068U986"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP04842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="277" mass="30635" checksum="0463E34E10557D38" modified="2014-10-01" version="1">MSNFRSISINIKGRTAWVGAGATVGEAYNSIYEANSNLGFPAAYCPTVGIGGHISGGGYGPLVRQFGLATDNVIDANGRVLDRKSMGEDLFWAIRGGDGASFAVILGYKLKLVEIPEKVTAFSINRTWEQNATQLLYKWQYIAPKLPLNLVITPQIVSINSNQTVDELLSIMNQQFPELGLKKEDCTEMLWIQYFAYAGGLPTSSIKEFLTSRVSSTKLYYKAKSDFVKEPIPEKEIEEILRKLNELPPFVGMLEWNHFGGGVMETIPESSLICFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UA97</accession>
    <name>A0A068UA97_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00020554001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UA97"/>
    <dbReference type="STRING" id="49390.A0A068UA97"/>
    <dbReference type="Gramene" id="CDP05485">
        <property type="protein sequence ID" value="CDP05485"/>
        <property type="gene ID" value="GSCOC_T00020554001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UA97"/>
    <dbReference type="PhylomeDB" id="A0A068UA97"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF36">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="121"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP05485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="387" mass="45223" checksum="6D7B729C051D9170" modified="2014-10-01" version="1">MYSIAQNYSIPNNRQMLSSEAKKLQNFFGFFVKLPSKEKLLGFHLSAAELPRLNHPPKADGSLSFLLVGDWGRKGSYNKSEVCKLIFLYQSYCHNMFVYLFYFLSFCVCVCAYIYIYIYIYILILNVFLCVVLGNHDYRGNVEAQFSPVLTEKDKRWLCFRNFMLNVATVEKLVDVIFVDTTPFIDEYFVNPRDPSYDWKGILDFERKLENSCRSSHNQKCWASCVERPKSLLILYCQSSRPQEYRLYRSEHFTLLMPLNERSGSNLKFLNGFHTLGAYSCRKFLTSDSNLTFFFQANKVDFYINGHDHCLEHISGIDGHIQFLTSGGGSKSWRGDVRSWNSEVMKFNFDGQGFMEFRGDEANFTFYDVYGAVFHNFRISKELRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UB03</accession>
    <name>A0A068UB03_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SIEVE ELEMENT OCCLUSION B-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00020519001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739100">
        <property type="protein sequence ID" value="CDP05462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UB03"/>
    <dbReference type="FunCoup" id="A0A068UB03">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UB03"/>
    <dbReference type="Gramene" id="CDP05462">
        <property type="protein sequence ID" value="CDP05462"/>
        <property type="gene ID" value="GSCOC_T00020519001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UB03"/>
    <dbReference type="OMA" id="GKFWLVA"/>
    <dbReference type="OrthoDB" id="1854460at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UB03"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010088">
        <property type="term" value="P:phloem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027944">
        <property type="entry name" value="SEO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027942">
        <property type="entry name" value="SEO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039299">
        <property type="entry name" value="SEOA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33232">
        <property type="entry name" value="PROTEIN SIEVE ELEMENT OCCLUSION B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33232:SF20">
        <property type="entry name" value="PROTEIN SIEVE ELEMENT OCCLUSION B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14577">
        <property type="entry name" value="SEO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14576">
        <property type="entry name" value="SEO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sieve element occlusion N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Sieve element occlusion C-terminal" evidence="3">
        <location>
            <begin position="443"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP05462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="77152" checksum="39A2C3B2148209B2" modified="2014-10-01" version="1">MEMDRVKEVLDTHVPDGRDFDVKPLVPIVEDIMKRATFLGGGAQDQDYADTWEDTAIRSGYTDMPELTYAINKTINEIICNCSSGGDEHFVAIALCRSLSRYAWEDKVAIALAAFAVSYGKFWLVAQLRTTNPLAKSLAVIRELPEIIEHTEALKRKFEAVSNLSKAMLNVTSCIINLKELPIEDIGQSNEWVFLTAHVPTAVYWTVRSIAACSFILNLTALGPEYVDSAAEAWDLNGVAHKLAKIKEDLKEQMNSIKQKIEDKRQDDAYNALVELFKTPNTDNTKILSAVINVKEDQLPLYDGTNKKRASIDILRKKHVLLLISELHIPQEEPSILHQFYTESRQQPTKLDKQYEVVWLPVVDTFSNATDEQFELVQNSMPWYSVHPIMLEPAFIRFIKDVKSFDKTPQLLVLHPRGILPGHNARDMMWVWGNLAFPFTEEREKELWTEATLIELLADSIHQNLLLWADQNRYICLYGGADIEWIRRLTTIMRSVANTARIPLEMLYVGKKNPKESMRKNNFIIQAENLSHILPDLIKIQIFWMRLDIMLKSWGQHGMFVKSDLIHHVGKIICYDQDGEGWAFIARGRHEMAKGTDKEVYQCLSKFDEWKDKVVYPDGFVIALGEQLRELQTPHHCNRLILPESTGHIPEKVVCAECGRPMESFIMYRCCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UBL9</accession>
    <name>A0A068UBL9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00019952001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739099">
        <property type="protein sequence ID" value="CDP05038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UBL9"/>
    <dbReference type="Gramene" id="CDP05038">
        <property type="protein sequence ID" value="CDP05038"/>
        <property type="gene ID" value="GSCOC_T00019952001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UBL9"/>
    <dbReference type="OMA" id="LHQQMKG"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34467:SF1">
        <property type="entry name" value="OS05G0542300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34467">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654738" evidence="2">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP05038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="83" mass="8972" checksum="EA41371134B9B7D0" modified="2014-10-01" version="1">MQLRISTSLLVYLLILNLLSSGKVEGFSNGVNHMYSADKDGVVIGNNRKVQVLDVALDYDYAGPNPKHDPRGKKPGGGGYKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UCX5</accession>
    <name>A0A068UCX5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00021396001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UCX5"/>
    <dbReference type="Gramene" id="CDP06044">
        <property type="protein sequence ID" value="CDP06044"/>
        <property type="gene ID" value="GSCOC_T00021396001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UCX5"/>
    <dbReference type="OMA" id="RANAENC"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UCX5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF58">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001654776" evidence="7">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="341" mass="38764" checksum="89FBC321BB538E8D" modified="2014-10-01" version="1">MFFIVSLLFLPHLLRANAENCDFFQGSWVFDESYPTYNSSICPFIEKEFNCLRNGRPDHLYLKYRWQPQGCDLAKFDGRAFLQKFRGKSILFAGDSLTRDQYMSLACLLYTSVPGTNYNMTREGLISTLKFLDYGLTLILDRNAFLVDLVPEKIGVVLKLDSVAGSEKLWSGHDLLAFNTWHWWGYKGAQQPWKYIQIGTRLLTDMDRMVAFETALETWAKWVDTNVDPAKTTVFFLGVSPSHYKGSDWNQPQVKNCAGQTRPLPGPTYPGVLPPALAVQKKVLSEMRVPVKLLDITTLSQLRVDAHPSFYGAATAAADCTHWCIAGLPDTWNQLLYNLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UDB9</accession>
    <name>A0A068UDB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00022967001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739104">
        <property type="protein sequence ID" value="CDP06247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UDB9"/>
    <dbReference type="Gramene" id="CDP06247">
        <property type="protein sequence ID" value="CDP06247"/>
        <property type="gene ID" value="GSCOC_T00022967001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UDB9"/>
    <dbReference type="OMA" id="QFNFPHK"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UDB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002238">
        <property type="term" value="P:response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="194"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP06247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="343" mass="38691" checksum="2B9F865BEE963EDC" modified="2014-10-01" version="1">MASIKTLVQSQDLKSLPSEFAHFKDTQESIRTGPEVSVPVIDFSLLSSTDPDERAKVILDLGKACEEWGFFLVVNHGIPENLISALFNVCNEFFDMPEKEKLQFENKHPLYPVMVRSGTIDGNDSNQKVKLWRDYLRFFVHPEYHCPTKPKALSDIVLEYSRRTRDLAKKLLGGISQSLGLEEDYIEKAMELDSSTQIFAANYYPPCPQPELAIGIPPHTDPGLLTFLLQNGVEGLEIQNKGKWFQLTGIPGAIFVNTADQLEIMSNGKYKSVWHRAVLNNKKTRMSLVVANGPSPDTIVTPAPQLLRETPAAYGPMKYMEYVQVQRSSRLNQKPTLDQLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEC2</accession>
    <name>A0A068UEC2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sec-independent protein translocase protein TATA, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00023811001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast thylakoid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739107">
        <property type="protein sequence ID" value="CDP06816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEC2"/>
    <dbReference type="FunCoup" id="A0A068UEC2">
        <property type="interactions" value="890"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEC2"/>
    <dbReference type="Gramene" id="CDP06816">
        <property type="protein sequence ID" value="CDP06816"/>
        <property type="gene ID" value="GSCOC_T00023811001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEC2"/>
    <dbReference type="OMA" id="WGTTAEP"/>
    <dbReference type="OrthoDB" id="1923722at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEC2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.3310:FF:000003">
        <property type="entry name" value="Sec-independent protein translocase protein TATB, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011429">
        <property type="entry name" value="PRK14857.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011430">
        <property type="entry name" value="PRK14861.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33162">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33162:SF1">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01506">
        <property type="entry name" value="TATBPROTEIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP06816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="15795" checksum="A616E37E82325C87" modified="2014-10-01" version="1">MAISSVSISSTLVPISSTKPPPSLPSSFSSSNSLFFSTNRSGFSLGSSKIKNNSASSRARKRGLSCTCLFGLGVPELVVIAGVAALVFGPKKLPEVGRSIGKTVKSFQQAAKEFESELKKEPISAAEPSAEKVKAVSDEGGQDAEVKSIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEN0</accession>
    <name>A0A068UEN0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00021456001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739103">
        <property type="protein sequence ID" value="CDP06088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEN0"/>
    <dbReference type="FunCoup" id="A0A068UEN0">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UEN0"/>
    <dbReference type="Gramene" id="CDP06088">
        <property type="protein sequence ID" value="CDP06088"/>
        <property type="gene ID" value="GSCOC_T00021456001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEN0"/>
    <dbReference type="OMA" id="MKWARYV"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UEN0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000035">
        <property type="entry name" value="Cationic amino acid transporter 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF62">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 8, VACUOLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="9">
        <location>
            <begin position="542"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP06088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="617" mass="67834" checksum="983AB2BFE0B84569" modified="2014-10-01" version="1">MNNNNASASHQNFSQEHLKSPLILPFAAAAKMEQPPEPTAKRSYWRFSKEDFFPEPTFENFSTYRSAVAKTPQRLKDRLLSRSSDDTELVVLKKQSENSMHQCLTWWDLMWLGFGSVVGSGIFSLTGQEIHDHAGPAIVLSYAISGLSALLSVFCYTEFSVDIPTAGGSFSFLRIELGDFLAYIAAGNILLEAIVGAAGLGRSWSSYFASVISSNPDLLRIKIDSFPEGFNLLDPLAVGILALCNGIAMSGSRRTSILTWVSSLISAGVIIFIIIVGFIHADTSNLVPFFPYGPKGMFTAAAVVYWSYTGFDMVATMAEETKKPSRDIPLGLVGSMSMITIIYCLMALALAMMVKYTEVDVNAAYSVAFEKIGMKWAKYLVGICALKGMTTSLLVGSMGQARYTTQIARSHMIPPYFALVHPKTRTPIYATLLVTTLSCILSLFSSLDVLSSVFSFSTLFIFMLMAVAVLVRRYYVKDVTPRNDHVKFLGCLFVIFGSSIGVTVFWCLNKGGWIGYVVTGVFWLIGTLGMAFLPRKRSPKVWGVPLVPWLPSLSIFINIFLIGSLGVVAIWRFVIASVVMLVYYVLVGVHTTYDVSHPEEPELKIEEGKANENQGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UEQ7</accession>
    <name>A0A068UEQ7_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00024050001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETICULATA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UEQ7"/>
    <dbReference type="Gramene" id="CDP06981">
        <property type="protein sequence ID" value="CDP06981"/>
        <property type="gene ID" value="GSCOC_T00024050001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UEQ7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021825">
        <property type="entry name" value="RETICULATA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31038">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31038:SF10">
        <property type="entry name" value="OS04G0524400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11891">
        <property type="entry name" value="RETICULATA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP06981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="584" mass="63561" checksum="7F8F2C88164CFC01" modified="2014-10-01" version="1">MCSTSSRNISLAALLQPVSYKNRAPLQPLNPQYAEPDGIYRSVPTLKLSCSGPRPRNRLIIRCSSEVLVEPMIGNGFGEDVYCRDLNLEDSHHLYLIGVEGLRESIIQNGVVRDGCNCYRDRYLQELFEAVEGFEERRTGIRVSEDHYKRYWAGKPIDMILRDHLKGACITGVPSDLLRPWWDVQRAANGGSELINVRSVSKTFYSRILRKQSPTQHVRFGMASSSPFPPEPININIISQSNIIFNGSHLSQHIGPEIRSRPTIEAGSGGDGGNGNGRLPPSGCARGGGGKDDDDGDVYDDQFSRFMKAAAEKMRAEANANAEAAKAEAAAKSMGTLGLMSRFGLLVASCWILGNPILADPSLLFKVGIATQVVTGSCFSTFAELKKKGMEFWSRLFAADILFGITVDIALGGVLATYARMGLMPSASGGFFGHMQRAYSSLPSSIFEGGSPGFNISLQQQGLTYFYEGILFGTAGLGCGLIYHAIVNLIRTGNRNAKKSEEENLVSSIVKNVTLWGVFLPLSSDTRHQIVKGLEKQIKASSVAKQVPFTALAFAVGIRFANSVFGGLLFANWAKWSGIMKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFB9</accession>
    <name>A0A068UFB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Germin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00023932001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739108">
        <property type="protein sequence ID" value="CDP06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFB9"/>
    <dbReference type="Gramene" id="CDP06894">
        <property type="protein sequence ID" value="CDP06894"/>
        <property type="gene ID" value="GSCOC_T00023932001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFB9"/>
    <dbReference type="OMA" id="MNMTMPK"/>
    <dbReference type="OrthoDB" id="1546383at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6 7 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019610771" description="Germin-like protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="10">
        <location>
            <begin position="62"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="208" mass="22381" checksum="EEFB55F38C30F844" modified="2014-10-01" version="1">MASFSFKFTLLSLLAIFANSWMAIARDPDILTDFIVPPNLNGSEITGHFFTYHLNTTGNGGPDARETDVTMDEFPALNGQGVSLAVYTFPPRSAYPTHIHPRASELFLVTKGKVEVGLVDTANKLYKNSLGAGDVFLFPKGLVHYQYNALARASASAVSFFGSASPGEVSLPTTLFATGIDDGILAKIFKTDVPTIQKLKSGLATPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFC4</accession>
    <name>A0A068UFC4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024446001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFC4"/>
    <dbReference type="Gramene" id="CDP07240">
        <property type="protein sequence ID" value="CDP07240"/>
        <property type="gene ID" value="GSCOC_T00024446001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="66" mass="7351" checksum="612F6EA365FED375" modified="2014-10-01" version="1">MIIFVLVSYQKQRRNSRWVALVLVVAGASCSWRRRRIISRFKEDTSGGSLKGEGSLDGESSHVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFE6</accession>
    <name>A0A068UFE6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Localized to the inner membrane of the chloroplast</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00024490001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739110">
        <property type="protein sequence ID" value="CDP07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFE6"/>
    <dbReference type="STRING" id="49390.A0A068UFE6"/>
    <dbReference type="Gramene" id="CDP07270">
        <property type="protein sequence ID" value="CDP07270"/>
        <property type="gene ID" value="GSCOC_T00024490001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFE6"/>
    <dbReference type="OMA" id="GERQYGV"/>
    <dbReference type="OrthoDB" id="1700403at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFE6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040377">
        <property type="entry name" value="Ssl2009-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34048:SF5">
        <property type="entry name" value="INNER MEMBRANE LOCALIZED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34048">
        <property type="entry name" value="LOW-DENSITY RECEPTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18089" checksum="A800C3B39CD4AA1F" modified="2014-10-01" version="1">MATLSSSLVLSKNPSFHSSPSSSGSSLKTLEQCMGSTVPTNLSFGLRHSRKSSISKGVLTVRATYSDGRSSTGNLFLGGFILGGLVIGTLGCVYAPQISSALAGTDKKDLMRKLPKFIYDEDKALEKQRKKLSEKIAQLNSAIDDVSNQLRSENTTNGADVNSDEVEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UFS1</accession>
    <name>A0A068UFS1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00023343001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739106">
        <property type="protein sequence ID" value="CDP06478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UFS1"/>
    <dbReference type="FunCoup" id="A0A068UFS1">
        <property type="interactions" value="1955"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UFS1"/>
    <dbReference type="Gramene" id="CDP06478">
        <property type="protein sequence ID" value="CDP06478"/>
        <property type="gene ID" value="GSCOC_T00023343001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UFS1"/>
    <dbReference type="OMA" id="MPIRKEG"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UFS1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000020">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF532">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP06478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="348" mass="38408" checksum="54EF130C7D4FC921" modified="2014-10-01" version="1">MGVDYYKILQVDRNAKEDDLKRAYRKLAMKWHPDKNPNNKKDAEAKFKQISEAYDVLSDPQKRAVYDQYGEEGLKGQVPPPSAYASTSDGGGPTMFRFNPRNPDDIFSEFFGFSSPFGGMGGMGDMGGPRSAGSSFSRGMFSDDIFASFRSATTEGSSGSVPRKAAAIERTLPCSLEDLYKGTTKKMKISRDVNDANGRPTTMEEILSIEIRPGWKKGTKITFPEKGNEQRGFIPSDLVFIVDEKPHIVFKRDGNDLVITQKISLVEALTGYTAQMTTLDGRSLAIPINSIISPTYEEVIKGEGMPIPKEPSKKGNLRIKFNIKFPTKLTSEQKTGIKRLLTSPGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UHF4</accession>
    <name>A0A068UHF4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(+)-neomenthol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00026659001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UHF4"/>
    <dbReference type="FunCoup" id="A0A068UHF4">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UHF4"/>
    <dbReference type="Gramene" id="CDP08000">
        <property type="protein sequence ID" value="CDP08000"/>
        <property type="gene ID" value="GSCOC_T00026659001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UHF4"/>
    <dbReference type="OMA" id="YWANDSV"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UHF4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000387">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF60">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP08000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31742" checksum="642657726D780FF9" modified="2014-10-01" version="1">MKCDCRWWSKDTVAIVTGANKGIGFALVKRLAELRLTVVLTARDNARGQEAVESLTRLGHHHVHFFCLDVSDPLSIKQFASWFKEKFAAVDILVNNAAVSFNDIHENSVEHAETVMRTNFYGPKLLTEALLPMFRSSASFGRIINISSRLGLLNKLKNPKLRDILMDGEKLSESQIQEMVELFLENVKNGTWQNQGWPEVWTDYAVSKLALNAYSVVLAKRLKGHGISVNCYCPGFTRTSMTGGKGKYTADDVAEVAAKLALLPPQVLPTGKFYTVSNSGGIYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIM1</accession>
    <name>A0A068UIM1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00026856001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739114">
        <property type="protein sequence ID" value="CDP08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIM1"/>
    <dbReference type="FunCoup" id="A0A068UIM1">
        <property type="interactions" value="1394"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP08122">
        <property type="protein sequence ID" value="CDP08122"/>
        <property type="gene ID" value="GSCOC_T00026856001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIM1"/>
    <dbReference type="OMA" id="DKVMGMT"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIM1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08295">
        <property type="entry name" value="double_bond_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF79">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="62"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="38713" checksum="ABC9113B81C98B6F" modified="2014-10-01" version="1">MAAEVEVVKNKQVLLKDYVTGFPKESDVIISTENTISLKVPENSSGVLVKNLYLSCDPFMRGLMRKPAPNSRTPLPAYKPASPIYGFVVAKVVDSSHPKFKKDDLVWGLAGWEEYSLITETDLLFKIEHTDVPLSYYTGILGLAGITAYGGFYEVCNPKKGEKVFVSAASGAVGQLVGQFAKLTGCYVVGSAGSKEKVDLLKNKFGFDGAFNYKEEHDLDAALKRHFPQGIDIYFENVGGKMLDAVLLNMNMFGRIAVCGMISQYNLDEPEGVKNLMWLIHKRINMRGYSAAEYYPHYTKFLDLVLPHIREKKITYVEDIAEGLESVPAALAGLFSGRNVGKQVIVVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIV7</accession>
    <name>A0A068UIV7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00027415001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739117">
        <property type="protein sequence ID" value="CDP08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIV7"/>
    <dbReference type="FunCoup" id="A0A068UIV7">
        <property type="interactions" value="1537"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIV7"/>
    <dbReference type="Gramene" id="CDP08490">
        <property type="protein sequence ID" value="CDP08490"/>
        <property type="gene ID" value="GSCOC_T00027415001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIV7"/>
    <dbReference type="OMA" id="THIICCT"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIV7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd05243">
        <property type="entry name" value="SDR_a5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000408">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF48">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="350" mass="37952" checksum="313473351855FABB" modified="2014-10-01" version="1">MASTLPFPPISCKIFPNQSQNFPVLPLHLPYSSSVHSLFRLKSSASSSRKVSSSSSSPSTSSVSSVSDTLVEEEVLQSPNPESVEVSQKNPSSKLVLVAGGSGGVGQLVVASLLGRNIKARLILRDPEKATSLFGKQDEAKLQIVRGDTRNPQDLDPAIFEGITHVICCTGTTAFPSRRWDGDNTPERVDWEGVRNLVSALPPSVKRIILVSSIGVTKCNELPWSIMNLFGVLKYKKMGEDFVRNSGLPFTIIRAGRLTDGPYTSYDLNTLLQATAGERRAVLLGQGDKLVGEVSRLVVAEACLQALDIDLTEGQIYEINSIKGEGPGSDREKWQELFKSAHTQSLQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UIX8</accession>
    <name>A0A068UIX8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit C, chloroplastic/mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GATC</name>
        <name evidence="2" type="ORF">GSCOC_T00026961001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="HG739115">
        <property type="protein sequence ID" value="CDP08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UIX8"/>
    <dbReference type="FunCoup" id="A0A068UIX8">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UIX8"/>
    <dbReference type="Gramene" id="CDP08202">
        <property type="protein sequence ID" value="CDP08202"/>
        <property type="gene ID" value="GSCOC_T00026961001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UIX8"/>
    <dbReference type="OMA" id="CRDAIVE"/>
    <dbReference type="OrthoDB" id="2020502at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UIX8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.60">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="157" mass="17746" checksum="1CEE1C640367E053" modified="2014-10-01" version="1">MGSRAFMVLLSHRGAYINPSANAAQLFLTFGQSPFSPVKKKCLVERRNHRTSHNFSTAANSSLEPPNLPRLAETARISLTPDEVEEFAPKMKQVVDWFGQLQAIDLESIEPAMRADTEDDNSRDDLPQIFENREAIIKAMPSYEEPYIKVPKVLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UJJ5</accession>
    <name>A0A068UJJ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00027243001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739116">
        <property type="protein sequence ID" value="CDP08404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UJJ5"/>
    <dbReference type="FunCoup" id="A0A068UJJ5">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UJJ5"/>
    <dbReference type="Gramene" id="CDP08404">
        <property type="protein sequence ID" value="CDP08404"/>
        <property type="gene ID" value="GSCOC_T00027243001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UJJ5"/>
    <dbReference type="OMA" id="FTKFFNG"/>
    <dbReference type="OrthoDB" id="1666376at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UJJ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050655">
        <property type="entry name" value="Plant_B3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31920">
        <property type="entry name" value="B3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31920:SF135">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS03G0621600-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="7">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP08404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="288" mass="32955" checksum="C0810B927FB84CC5" modified="2014-10-01" version="1">MVKPGRGRPRKDSSSSSYLSFMDARPEFFKVFLPDVSSQQLRVPPLFVKKFSGLVCKRIKLRCIDGKIWDVDVEETQEGVFMKNGWQAFADHHLLKLGEFLVFRYDGNSVFTVKIFRTHGCKEEAFVREKIAADVKIEPLEDQIAATEHTCAKHSCNSDGEGNKLDTSRGVREGKQQMSSRFHSQTVQTERDSEFGSIRSISRTQMHKLMLSKGFISKNNIKLGSNVMLCNEKEEKWPVKFTHFRDGRACIGTGWMAFWKDNGMCEGDKFKLVFDEGRGRKMITVCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UKR9</accession>
    <name>A0A068UKR9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00028255001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP09066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UKR9"/>
    <dbReference type="STRING" id="49390.A0A068UKR9"/>
    <dbReference type="Gramene" id="CDP09066">
        <property type="protein sequence ID" value="CDP09066"/>
        <property type="gene ID" value="GSCOC_T00028255001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UKR9"/>
    <dbReference type="OrthoDB" id="1920894at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UKR9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46444">
        <property type="entry name" value="DCD (DEVELOPMENT AND CELL DEATH) DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46444:SF11">
        <property type="entry name" value="DCD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="275"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="167"/>
        </location>
    </feature>
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        <location>
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            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="547"/>
        </location>
    </feature>
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            <end position="100"/>
        </location>
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            <end position="138"/>
        </location>
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        </location>
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            <end position="229"/>
        </location>
    </feature>
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            <end position="248"/>
        </location>
    </feature>
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        </location>
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            <end position="535"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="644" mass="74726" checksum="1C3FC07E2E97A749" modified="2014-10-01" version="1">MPRSANCFRGWRSSILPSEDNNNSTRLKMVHQESEVDVSTSNLSAEDNVAAETTLVGAELSNHPVGMDVMPTEIVPQSEHKVENTLDELENESKDEENVNEESGKGEGPYDDEDEEDDDVDYDYDDNDDDALMEEGSEIENKENDMCEVKDNNKSTTGEESENEEKECCSLAPKMKKVGNKNGRNKVVNEELGKLASKREAKLGGGEHNVPIVREDEKNARAEIEEKGEGSANKKGKKSRKRNRRKVKEGKAEKVASKSKDKLKPSGKKRTLKKAASMGMIFMCSSKTKRDCYRYKVLGLPANKRDIVEKVYKGMRLFLYDVDLKLMYGIYKAAGPGGYNIEPKAFKSQFPSQVRFIVMEDCIPLAEDKFKKVIKENYFTRTKFDCQLKSEQVRKLCKLFVAVSKRPRSQGLDRGFKEKTYASIGQGRLRVLDIDEERRSALDEKRQYPRIHQREVIASPLDPVHRFAPLRPPAAAPLYAYDRTTERDAYRQNLLSEHRDSYRRRPLESRDAYRWEPYGQPLLDSRDSFRRERSRQSPLQSPDVYREDTLLDHRENHGWDGVVEHLNPRPLKLEARHRDDIAMDDPYILYRERQLYRDPVYIQNLSPERDCYLPVGRRYKYRSREDPLTEYRSTRSFTRARYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UL80</accession>
    <name>A0A068UL80_COFCA</name>
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            <fullName evidence="10">Rx N-terminal domain-containing protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
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            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Genoscope - CEA"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">DH200</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DH200</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739092">
        <property type="protein sequence ID" value="CDP02206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CDP09285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UL80"/>
    <dbReference type="STRING" id="49390.A0A068UL80"/>
    <dbReference type="Gramene" id="CDP02206">
        <property type="protein sequence ID" value="CDP02206"/>
        <property type="gene ID" value="GSCOC_T00039528001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP09285">
        <property type="protein sequence ID" value="CDP09285"/>
        <property type="gene ID" value="GSCOC_T00028575001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UL80"/>
    <dbReference type="OMA" id="YHPEPKE"/>
    <dbReference type="OrthoDB" id="2973320at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="NB-ARC"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF51">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00931"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP02206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP09285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25632" checksum="F5B2E19BD1C5170F" modified="2014-10-01" version="1">MALIEVFLGAIIKVIFDKLASVDLKKLARSEGLDTQLKRWSQVLSLINAVLDDAEEKQNMRIAVKQWLDDLQDLAYDMDDVIDEFSTEACRRKLMEAQGSTSKFNRKMAPKVDEITRRLESLKEQIKILHLVETVAKRPNKTRDRLPSTSLVESYVYGRENDKKELLKLLLSNESSDDQVAVIPIVGMGGVGKTTLAQMVYNDDRVNEFFDSKAWACVSDDFDIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMR5</accession>
    <name>A0A068UMR5_COFCA</name>
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        <recommendedName>
            <fullName evidence="5">Benzyl alcohol O-benzoyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739123">
        <property type="protein sequence ID" value="CDP09539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMR5"/>
    <dbReference type="STRING" id="49390.A0A068UMR5"/>
    <dbReference type="Gramene" id="CDP09539">
        <property type="protein sequence ID" value="CDP09539"/>
        <property type="gene ID" value="GSCOC_T00028954001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMR5"/>
    <dbReference type="OMA" id="RITFTHR"/>
    <dbReference type="OrthoDB" id="1483986at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050898">
        <property type="entry name" value="Plant_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147:SF66">
        <property type="entry name" value="OS05G0315700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP09539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49015" checksum="009BBF6158010496" modified="2014-10-01" version="1">MESVSASSKSLTFRVTRQKPELVRPAKSTPRECKLLSDIDDQEALRIQIPFIQFYRNRDDPGINESRRRSDPVKVIREAIAKALVFYYPLAARLREGPGRKLMVECTGEGVLFIEADADVTLEQFGDAIQPPFPCLEELLYDVPHSGGILHCPIVLIQVTRLRCGGFIFALRMNHTIADGVGIAQFMNAVGEIARAASAPSIQPVWQRELLYARDPPRVTCSHHEYDEVVVDTKGTIVPLDDMVHRSFFFGPAEVSALRKSIPLDLSHRCSTFDILTAFLWRCQTIALQYDPNEEVRVICIVNARFKFNPPLPQGYYGNAIAYPTALTTAGELCEKPVGYAVELVTKAKRVVTEDYMKSVADLMIVDFGWGKPVYGGPAQGTVACFHIPFKNKKGETGRVVPIFLPGLAMDRFVNELENFFLSHNVRPHFRRATSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UMV4</accession>
    <name>A0A068UMV4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00028098001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739120">
        <property type="protein sequence ID" value="CDP08953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UMV4"/>
    <dbReference type="FunCoup" id="A0A068UMV4">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UMV4"/>
    <dbReference type="Gramene" id="CDP08953">
        <property type="protein sequence ID" value="CDP08953"/>
        <property type="gene ID" value="GSCOC_T00028098001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UMV4"/>
    <dbReference type="OMA" id="IHCQGHN"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UMV4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19493">
        <property type="entry name" value="Rad51B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030548">
        <property type="entry name" value="RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="80"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP08953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="358" mass="38765" checksum="5321A4817D4124C0" modified="2014-10-01" version="1">MANKLISEMGLPKSIANIFAARNIHTAKDALSLTEFELTELLDVGLAEVTTAVSSISEISCPPYQTALSLLEQRMHNEHLAGHLPTRLKGLDAALCGGIPFGVITELVGPAGIGKTQFCLKLSLLASLPSSHGGLDGHVIYVDTESKFSSRRMIEIGVNSFPEIFQIEGMAQQMAGRILVLQPTTPTEFSECLQKIKDSLLQHHMKLLVIDSMAALVSGRDGQGQCRQHPLGWHMTFIKSLAEFSRIPVVVTNQVRSHSGDDPFHYSFQDSRQNLDFPTTFDSHLVAALGIPWAHAVSIRLVLESKSGQRFIKLAKSSMSPPVAFTFAISASGISLLHDDGIEMTGPEINGICGQGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068US94</accession>
    <name>A0A068US94_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00033229001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739136">
        <property type="protein sequence ID" value="CDP11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068US94"/>
    <dbReference type="Gramene" id="CDP11162">
        <property type="protein sequence ID" value="CDP11162"/>
        <property type="gene ID" value="GSCOC_T00033229001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068US94"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="68" mass="7736" checksum="A981F4BAF1A0841D" modified="2014-10-01" version="1">MRMTLENYWAFLEKEGTEFRDLLKCTGGTNRGVSYKVIWDLQRCAGGTDPVILDLRSIGKRSGLGKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UUJ5</accession>
    <name>A0A068UUJ5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00035260001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDP11944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068UUJ5"/>
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        <property type="protein sequence ID" value="CDP11944"/>
        <property type="gene ID" value="GSCOC_T00035260001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UUJ5"/>
    <dbReference type="OMA" id="CRRMIWY"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UUJ5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP11944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="151" mass="17169" checksum="1B99A98CAA948662" modified="2014-10-01" version="1">MSSLSANDLHKIFTKLDKNGDGLMSIDQVKWLLERIGFHTTLEELQRLVGPTTSLDSIDFFIFYDIVVKSNIGRSNQTNSFDGDLAEAFKVFDLNGDGFISCEELQKVLSRFGLWDEREGRDCKSMINIFDTNSDGLLDFEEFRTMMVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV30</accession>
    <name>A0A068UV30_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00035509001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
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                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDP12119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UV30"/>
    <dbReference type="Gramene" id="CDP12119">
        <property type="protein sequence ID" value="CDP12119"/>
        <property type="gene ID" value="GSCOC_T00035509001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV30"/>
    <dbReference type="OMA" id="FTEHKNH"/>
    <dbReference type="OrthoDB" id="777519at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV30"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF140">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR CRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="371" mass="40891" checksum="0FE3BF2A2AA41C55" modified="2014-10-01" version="1">MRDMLTNKKGVKYTEHRKQTTMVRPSPLPTSLACRTRKSPDMNAVKPRVVRISVTDADATDSSSDEDEEAFKRRHRVKRFINEVKIETFRDNGNGNVNACTSAGNVNSVWRSRGSAAPAAAGNGTSTTNKKRKKSSGGGGNGKQARVAEGSNVKKFRGVRQRPWGKWAAEIRDPARRVRLWLGTYDTAEEAAMVYDHAAIQLRGPDALTNFATPPARSVSPPAPESATCSGYNSGEESHNNQRSPKSVLRFASTSNSNEEAEAESCLPSPLHEEAVGIGKERRDSCGEETCVSENFSHYSLIPEDLRFEFEDPVVDFSDLFEDNSNIFEYARNFDNTFVDSSENVEFGSAMPDDFFSDLGDIFGKDPLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UV99</accession>
    <name>A0A068UV99_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RuvB-like helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00035819001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="HG739147">
        <property type="protein sequence ID" value="CDP12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UV99"/>
    <dbReference type="STRING" id="49390.A0A068UV99"/>
    <dbReference type="Gramene" id="CDP12341">
        <property type="protein sequence ID" value="CDP12341"/>
        <property type="gene ID" value="GSCOC_T00035819001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UV99"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UV99"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="88" mass="10334" checksum="BDCB2712C9F5330D" modified="2014-10-01" version="1">MANIYVKIDAWIWYFVFYVVSSYKRCQSQVVNHYIDDGVAELVQGVLFIDEVDMLDMECFSYLNRALESFLSPMVIFPANRGICNVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVI8</accession>
    <name>A0A068UVI8_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00035989001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739149">
        <property type="protein sequence ID" value="CDP12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVI8"/>
    <dbReference type="FunCoup" id="A0A068UVI8">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UVI8"/>
    <dbReference type="Gramene" id="CDP12436">
        <property type="protein sequence ID" value="CDP12436"/>
        <property type="gene ID" value="GSCOC_T00035989001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVI8"/>
    <dbReference type="OMA" id="TMSNKDG"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVI8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000224">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000269">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="463"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="846" mass="93783" checksum="91A9569B2C24E227" modified="2014-10-01" version="1">MEGEEANLQAAPPPAVPPPPPLSTNSNFLRNSINLEFTSTSTSTTSTSSSSSSLSNDAFFRNVQAVFKRHRPLSMMPSNNIQPRRMLVPQRGAPKSSSITTGSTFDIKKIEDEGLLSQKLRDCVSRSKDMVSVVSETPECASINAPSEWGSTVNTHDEGYKKFDGKSKQARSHAGHKTNDTVASVMESEHVPLVDGTKRVHFATQTDSRFQEMEWDGSNQTEAPTALSHRLQHQIIQSEEVDPESRISSSLARNLGVTDQLHQFGNFIQNDTSQPMTQSSVVGMSCATTTLINPGSAPNLNSTTYCSQTHQTSRSKLGLESVGDIEIKFQPVQPELLPSDPPSKCNSTVLSHQAATAAHVSIGTPEANLEAKNCIMPNEKECIVPKESDNSRNPRTLGGTSAAEDHIAVHPEPPSSKVQALDVKLEPDKSGKPEKVGGGKATSVSRKKSYDMDLFFKVNGKLYQRLGKIGSGGSSEVHKVISSDCTIYALKKIKLKGRDYGTAYGFCQEIEYLNKLKGKKNIIQLVDYEVTDKALLKEVTSGTMSNKDGRVKEDGYIYMVLEYGEIDLAHMLSQKWKELDSSSSTIDENWLRFYWQQILLAVNTIHEERIVHSDLKPANFLLVSGSLKLIDFGIAKAIMSDTTNIQRDSQVGTLSYMSPEAFMCNETDANGNTIKCGRPSDIWSLGCILYQMVYGRTPFSEYKTFWAKFKVITDPNHEIAYEPVQNPWLLDIMKKCLAWDRNQRWRIPQLLQHPFLVPPVPPQVSAPMDQSCKLLQLIGKSCQNDPQSFMLFSQLQQLLKDPRPSATSESSISHDEIHKLLSGVSNLCLQLQRQLANFEEIQLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UVX5</accession>
    <name>A0A068UVX5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00036224001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>deacetylisoipecoside + H2O = deacetylisoipecoside aglycone + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:78887"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58091"/>
            <dbReference type="ChEBI" id="CHEBI:229557"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:78888"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739152">
        <property type="protein sequence ID" value="CDP12571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UVX5"/>
    <dbReference type="STRING" id="49390.A0A068UVX5"/>
    <dbReference type="Gramene" id="CDP12571">
        <property type="protein sequence ID" value="CDP12571"/>
        <property type="gene ID" value="GSCOC_T00036224001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UVX5"/>
    <dbReference type="OMA" id="ARENNAM"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UVX5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033075">
        <property type="term" value="P:isoquinoline alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000022">
        <property type="entry name" value="Beta-glucosidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF137">
        <property type="entry name" value="MYROSINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP12571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="565" mass="64939" checksum="CD632D797348A7BD" modified="2014-10-01" version="1">MKLIKVVLCSESRSTKTKSEMQNQAYFFLVLLALPHSLFASSNDAKCQCDEAKINRGGFPENFLWGAGTSAYQVEGAYNEGGKGPSLWDNFTHAYPEKIVDQSNGDIAVNSYHYFEEDIKITKDLGLDAYRFSISWSRILPRGNRNGGVNQEGIDYYNNIINDLLANGIQPFVTMFHFNVPQALEDAYGGFLSSRIVADFLDFADILFSKFGDRVKYWITLNEPWTFSNHGYAIGRFAPGRCSEWQQINCTGGNSGTEPYIVTHNQLLAHAAVVHLYRTKYQIWQKGKIGIALAAIWFEPYNSTDENLMATDRALDFMLGWFMQPLTSGQYPQSMRVRAGNRLPNFSNTERDLLIQSFDFIGLNYYTSRYVLDKPNPSSLSYINDSEVDIVVERDNKPIGEVSVIGSWLHIYPKGLRELLNYMKMKYNNPTIYITENGNSKFIWLNEARNDSMTILEAIKDDIRKDYIHDHLCCILQAIEQFEVNVGGYFVWSLMDNFEWAFGYSIRFGIHFVDYNDELFTRYPKHSALWYKSILVKKIKIAQSIVSNDAKKDRQKYVPSNVFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UWU7</accession>
    <name>A0A068UWU7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00037764001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739156">
        <property type="protein sequence ID" value="CDP13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UWU7"/>
    <dbReference type="FunCoup" id="A0A068UWU7">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068UWU7"/>
    <dbReference type="Gramene" id="CDP13025">
        <property type="protein sequence ID" value="CDP13025"/>
        <property type="gene ID" value="GSCOC_T00037764001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UWU7"/>
    <dbReference type="OMA" id="NGPIPPM"/>
    <dbReference type="OrthoDB" id="783585at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UWU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008889">
        <property type="entry name" value="VQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039612">
        <property type="entry name" value="VQ_5/9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33783">
        <property type="entry name" value="PROTEIN HAIKU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33783:SF1">
        <property type="entry name" value="PROTEIN HAIKU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05678">
        <property type="entry name" value="VQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VQ" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="340" mass="37063" checksum="4ABF2E75052EFE21" modified="2014-10-01" version="1">MDNTNRQMNRHTDNLGVNKIGKNIKKSPMHQPNFTNAARQQPQPQVYNINKNDFRNIVQKLTGSPLHNQEPSAPRPPQNPPKPASMRLQKIRPPPLTPINRPPMVMQPPVPVPAPAQPPASVPYNNFTRPPLPQYGQPSPTMLPPFTPGDAWPNTAESPISVYMRYLQNSIIDSGPRQPFPQSIPQGPGPNQAQPSASGLLPNPHMPPFPSPRMNMPPPLPSPRMNGPPPFPSPRMNGPPPSLPSPRTNGPPPLLPSPTSQFLLPSPTGFLNLFSPRSSYPLLSPGFQHPPPMTPNFSFSPMAQSGILGPGPQVPPSPGYGFPLSPSGFFAIPSPRWRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXR9</accession>
    <name>A0A068UXR9_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00038228001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739158">
        <property type="protein sequence ID" value="CDP13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXR9"/>
    <dbReference type="Gramene" id="CDP13330">
        <property type="protein sequence ID" value="CDP13330"/>
        <property type="gene ID" value="GSCOC_T00038228001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXR9"/>
    <dbReference type="OMA" id="WAMCEGG"/>
    <dbReference type="OrthoDB" id="1673075at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXR9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="81" mass="8959" checksum="E3AEA26E6F6415D9" modified="2014-10-01" version="1">MALAGIWAMCGKSNSSGGSSLDSTIKKKDISTQRGGMEFESDWTKHCWKSSAFTAQAIRSATSFMPWSCKISRNEGFHEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068UXU7</accession>
    <name>A0A068UXU7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00037926001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739157">
        <property type="protein sequence ID" value="CDP13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068UXU7"/>
    <dbReference type="STRING" id="49390.A0A068UXU7"/>
    <dbReference type="Gramene" id="CDP13122">
        <property type="protein sequence ID" value="CDP13122"/>
        <property type="gene ID" value="GSCOC_T00037926001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068UXU7"/>
    <dbReference type="OMA" id="TTHPHIF"/>
    <dbReference type="OrthoDB" id="594804at2759"/>
    <dbReference type="PhylomeDB" id="A0A068UXU7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd22160">
        <property type="entry name" value="F-box_AtFBL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053781">
        <property type="entry name" value="F-box_AtFBL13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006566">
        <property type="entry name" value="FBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050232">
        <property type="entry name" value="FBL13/AtMIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31900">
        <property type="entry name" value="F-BOX/RNI SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31900:SF27">
        <property type="entry name" value="FBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08387">
        <property type="entry name" value="FBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00579">
        <property type="entry name" value="FBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="511" mass="58280" checksum="F3DACF45C699FCC7" modified="2014-10-01" version="1">MADPPEKKMLKRIPDGDNMDRLSALPNCVLLRILSRFKTKDAAATSVLSTRWRDLFVSLPDVDLSFRVDGDASDRDRMFSDFTDFANRVVRQRNKASIGTIVVDVMHFVKSYRLAFESLLISAAAALSSCNVQQLLISVRMDKTTERFSIPIPPGIFSSKTLVSLTVDIEVDWNAPDFVWLPNLKYLYLFEFRLVDEDSIQRLLQGCPLLEQLMLFVQPFSYESESEEGIEVEVLHISSPSLKSLVLSWNAKVELEFTVVVQSENLESLLCSLQGQHKVTIDAPNLKSLTVEGHVLEVHINQSLVSIDKAVVHAEFLHNVTNGSDLFSRVQHAFKFISGLQNVKSLNLSENILKALYCSQRVLPKFKDLNKLKLSHFRCHAFPRNPYSKVLSSLFESSPNLEVLIIDEVLKDSEDEELDSVFQEVLSLAFVGQLKEIEIRSFEGEEHEFKLIEYFLKNGKSLKKMDLIRDSWKTESDGCHRILSSKKCAVDCQILFITKWDLLQSLFLKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V025</accession>
    <name>A0A068V025_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00039058001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739162">
        <property type="protein sequence ID" value="CDP13917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V025"/>
    <dbReference type="STRING" id="49390.A0A068V025"/>
    <dbReference type="Gramene" id="CDP13917">
        <property type="protein sequence ID" value="CDP13917"/>
        <property type="gene ID" value="GSCOC_T00039058001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V025"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V025"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058920">
        <property type="entry name" value="PAP-OAS1-bd-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058921">
        <property type="entry name" value="PAP/OAS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979:SF6">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979">
        <property type="entry name" value="PAP/OAS1 SUBSTRATE-BINDING DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26180">
        <property type="entry name" value="PAP-OAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PAP/OAS1 substrate-binding-related" evidence="3">
        <location>
            <begin position="214"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP13917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="76251" checksum="D4664FEAEB8AD0F6" modified="2014-10-01" version="1">MDYTSVGSSSSFSSMSDKNLLHSEAECWLKAEKAAQDVLFVVQPTVLSYKKRLEIVSYVRELIRDIVGDEVRPSFVPKFWFGWTLEALLSMAVSFFWSVLPLTSLEHIHMGGHYALALQVMAFGSTPLKTYLPDGDIDLTVITSQNDVAYLVSSVCSILEEQICDSSPIKNVQVVDARVKIVKCWVQHMCVDISFNQVAGLHALCFLEQMDQYIGRGNLFKQSLILIKAWCFYESRLLGSHCNLMSTYALEILVLYIINIFHCSLSGPLAVLYKFLDYYSTLDWDKYCISVYGPVDINFLAKADVETSATRGTNLLLGKDFLESCIKSFSTSKGMFETERQEFRIKHLNIIDPLNHKNNLGRSISKGNLCRMKIAFSYGYEKLRDVLKGPLESIGEGVMGFLVNTIKWSGRLQTLDAEVSVVDNQSSIFHLKGDYNCPIQCLNYSQWYINSDVFRQSSLQTLPSVVQSQSTEDEFTQNIYFAGGADCFVPSSIVHPNAWQLLDSVLSVDETENYLGKCTSVSPASSKGKFKLSASAPPFISSPVSERAKCEGTGLFIPKVDIEREPKSKERDLRSPEAQCHDWRINSSQMKRYSVGSSLKTSTSNRMAGGIPFKSSRVRESSRFNVPREGHWLLSSRKTSAESDYDAGSSTFVLSLDDFPVLSSCKKPVTSRKAQPDSANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0H0</accession>
    <name>A0A068V0H0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00040557001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0H0"/>
    <dbReference type="FunCoup" id="A0A068V0H0">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0H0"/>
    <dbReference type="Gramene" id="CDP14265">
        <property type="protein sequence ID" value="CDP14265"/>
        <property type="gene ID" value="GSCOC_T00040557001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0H0"/>
    <dbReference type="OMA" id="KSLTKWA"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0H0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="205" mass="23283" checksum="2CABB5CB7CC292AB" modified="2014-10-01" version="1">MEGGGAAAVSAEKQPEAAATAASYNYWVREMTQDAAPLPVPRKLTSEDISNQGPNHLGSVWNRAGTWEEKSLNKWASDRMKELLQSVQSLEFSGGNAEISEVTRCSGDAFLVTVRNKKRVGYTYELALRVKGEWLIGSEKKEVKGYIDIEEFSFGELDDLQIQVRLSEEKDLQQEDKQRIIKDLKQFLQPVREKLNQFEQELKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0H4</accession>
    <name>A0A068V0H4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcium-transporting P-type ATPase N-terminal autoinhibitory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00040383001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739164">
        <property type="protein sequence ID" value="CDP14146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0H4"/>
    <dbReference type="STRING" id="49390.A0A068V0H4"/>
    <dbReference type="Gramene" id="CDP14146">
        <property type="protein sequence ID" value="CDP14146"/>
        <property type="gene ID" value="GSCOC_T00040383001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0H4"/>
    <dbReference type="OMA" id="FRWVANL"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0H4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium-transporting P-type ATPase N-terminal autoinhibitory" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP14146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="86" mass="10426" checksum="B5B68F075AAC6EE7" modified="2014-10-01" version="1">MSMKNLLNVDLKDFEIPAKHPSEEAQKNWRNLVTLVRNKRRRFRYGPNFEKRTEARERIEKLRHQEVTPHHMLFSLGKKLPYLIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0X6</accession>
    <name>A0A068V0X6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxypeptidase</fullName>
            <ecNumber evidence="9">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSCOC_T00040929001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="9"/>
    <dbReference type="EMBL" id="HG739169">
        <property type="protein sequence ID" value="CDP14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0X6"/>
    <dbReference type="FunCoup" id="A0A068V0X6">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.017"/>
    <dbReference type="Gramene" id="CDP14450">
        <property type="protein sequence ID" value="CDP14450"/>
        <property type="gene ID" value="GSCOC_T00040929001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0X6"/>
    <dbReference type="OMA" id="GIDCYNV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0X6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000123">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655311" description="Carboxypeptidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDP14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="450" mass="50124" checksum="B8545DB260A6744F" modified="2014-10-01" version="1">MEKSHVVLSLLLVLLFHVGIATAVKTEDGSEAWGYVPVRPKAHMFWWYYRSPNRIHDPKKPWPIILWLQGGPGASGVGLGNFEEFGPLDVFLKPRNSTWLQKADLLFVDYPVGTGYSFVEDVKNTTLFVKSDVEAAKDGTKFLTEFFNRNLTLQKSPLFIVAESYGGKFAVTLALSALKAIEAGKLKLNLGGVALGDSWISPEDFTSSWAPLLKDVSLLDGNGFQISNRVANQIKKQIAAGKFAEATDTWNELEDLITKYSNNVDFYNFLSFAEDDPSSLSAASELKQRIAVKRSSPGGDGDLYSLMNGDIKKKLKIIPPNVTWGGQSNSVFEALKGDFMRPRISEVDELLAKGINVSIYNGQFDLICATKGTNAWVEKLKWHGIKNFLNKDRTPLYCGGDKSIKGFTKSYRNLHFYWILNAGHLVSQQTIVIFLLHLFVSLKLLLLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V0Y1</accession>
    <name>A0A068V0Y1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="3 10">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00040639001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="3 10"/>
    <dbReference type="EMBL" id="HG739165">
        <property type="protein sequence ID" value="CDP14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V0Y1"/>
    <dbReference type="FunCoup" id="A0A068V0Y1">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V0Y1"/>
    <dbReference type="Gramene" id="CDP14316">
        <property type="protein sequence ID" value="CDP14316"/>
        <property type="gene ID" value="GSCOC_T00040639001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V0Y1"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V0Y1"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000629">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="211" mass="22993" checksum="DAF0688C3343891A" modified="2014-10-01" version="1">MATLGNSANIFWHECPVGQAERQKLLNQKGCVVWITGLSGSGKSTLACTLGRELHSRGHLSYVLDGDNLRHGLNKNLGFAPEDRTENIRRVGEVAKLFADAGLICIASLISPYRKDRDSCRALLPDANFIEARILVFMNMPLSLCEGRDPKGLYKLARAGKIKGFTGIDDPYEAPSNCEIELRQINGVCPAPSEMAGKVVSYLDGKGFLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1Q2</accession>
    <name>A0A068V1Q2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSCOC_T00041105001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739171">
        <property type="protein sequence ID" value="CDP14576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1Q2"/>
    <dbReference type="FunCoup" id="A0A068V1Q2">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1Q2"/>
    <dbReference type="Gramene" id="CDP14576">
        <property type="protein sequence ID" value="CDP14576"/>
        <property type="gene ID" value="GSCOC_T00041105001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1Q2"/>
    <dbReference type="OMA" id="GHEFGWL"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
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        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP14576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="617" mass="69969" checksum="6A5CB8CCD7F3A02A" modified="2014-10-01" version="1">MAVTETTVKKDTEVTVPPNLDGKSCESGSRAKLLVSNGCNKRKAEFVLDGEREKRKRLDPVVKQQCRTILETLITHPTGWIFRTPVDPVALNIPDYFSIISHPMDLGTIKSKLAGNRYFSAEEFASDIKLTFSNAMLYNPPDNPVHRMAKELECVFIRRWKLLEAKWKRETACAQQDTFSSKSEKTAQNTMRAFDKKSLEQISSGLEKNAQNRAKPSCKKPQGLISNGIEKKAQDTRKAFSKNSQGVVSNESEKNAQDTKKAFCKNSQGLISGKFEKNAQCKKSDTGLVAKRSMLLEERQKLKKDLIEMLKGKVNGKLQTVLQKFGFFDIRKEKIDVNIDDLQDDILWELKRVLKDSSDASSAKESKDKILSTQTKIQHRESKVIQDRETKTIQDCQSKTMSTHSCRVNADSVCQLTEGSGSGEDEEYTWPSSGLSTTITSAISGECWTPLIDDEQALKKALRIAKLKSRFAETISKANGDKTDAEQERERVKRLQREEELFKARIRGEQLKKEAELKRQRDKEREAARLALQLMEKAVQLEDNLMTLKELEMLTQCSPTFILHGCCPVMVLRRLETGEILNPLEQLGLHIKDDFLEEDDDEETFLTWEGEEGEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V1Q4</accession>
    <name>A0A068V1Q4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSCOC_T00040909001</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739169">
        <property type="protein sequence ID" value="CDP14444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V1Q4"/>
    <dbReference type="FunCoup" id="A0A068V1Q4">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V1Q4"/>
    <dbReference type="Gramene" id="CDP14444">
        <property type="protein sequence ID" value="CDP14444"/>
        <property type="gene ID" value="GSCOC_T00040909001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V1Q4"/>
    <dbReference type="OMA" id="FMQGCEA"/>
    <dbReference type="OrthoDB" id="1930390at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000237">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000013">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase LECRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF15">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655335" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="23"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="22">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="395"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDP14444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="686" mass="77391" checksum="73F798260D989E40" modified="2014-10-01" version="1">MAYVFLIHLTCFTLFFPFHILAQNSGLVSVGSILAANESSIPWLSPSGDFAFGFRQLQDKDMFLLSIWYDKIPDKTVAWYVGSVVNPVPRGSTVELQAKRGLVLRDPQGQDIWSTATIYDEVNYGFMNNTGNFIIMASNNNTRLWESFRFAVDTILPLQRLTYGSVLYSRQSETNFSRGRFSLRFHQDGNLLLRVGSVPILDADAVYYSSQTSDAVNPLNSGQFNYHRATLDFDGAFTHYFHPRTFTGKPNWTAFWAIPENICTAMDGTKGSGVCGYNSVCSLVGRKPVCECPQGYYLLDPNDKYGGCTPNFNQSCDELEQLPVEDKYDILAGSDIEWSNKSEYEVVNPSTEARCRKACLQDCLCAVALNLHPSKNGVEINLHCFSYKKLAEATNGFREELGRGSFGIVYKGEIKVGSIKDTVAVKKLDRVAQDAEKEFLAEVNTIGQTNHKHLVRLLGFCYEKQHRLLVYEYMGNGTLASLLFGKTIPSWKLRTQIATGIARGLVYLHDECSSQMIHCDIKPQNILLDDYYNARISDFGLAKLLQINQSRTLTNIRGTRGYVAPEWFRNTQITSKVDVYSFGVLLLEIICCRRHVEDVDTGEGGNAILTDWVWDCFQEGRLDALVENDFEVLEDTMKLEKYVKIGIWCIQEDPSLRPTMRKVSHMLEGIVEVMIPPCPSPFFSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2C0</accession>
    <name>A0A068V2C0_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042454001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739177">
        <property type="protein sequence ID" value="CDP14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2C0"/>
    <dbReference type="Gramene" id="CDP14950">
        <property type="protein sequence ID" value="CDP14950"/>
        <property type="gene ID" value="GSCOC_T00042454001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2C0"/>
    <dbReference type="OMA" id="TVLMQGQ"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2C0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF28">
        <property type="entry name" value="OS04G0488500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="777"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="95137" checksum="891A5B31097682C3" modified="2014-10-01" version="1">MVFLSKVLSFSPKSISRFIFAHSFSNSSLPKSLISRITTAFHQENPKLIDPVVSSKIQSCHLESVIHEFRSKPTSAIRFFKWSENFLGLNHTLKCHSMLCHLLLSKRMFDDARWVFAKMAEKFGEFDCLAVFDEGFKVYGADRSTVYSFLVDGYCRVGRINLSVELFFRMCKMGVSVSHYALLKMLSSLIDLRRLDLILDVYKEMENRSKGEPKRCFDVYGFVMNGFFKNEEASIGLEFHRKMIERGSKPDIVYCNKVLKSICCGYSCIEVANKLLLLLLDVGPRPNVVTFSTLINGYCKEQRLEEAFKLYVLMIGRGIEPDLIVYSILIDGLFKLGKFEEGHQLLSTALGKGVKLDVVIFSSIIDACVRDGDVERGVLVFKKMLKEGICPTLVTYGILVNGMCQIGCLLEAFGVLGQMLKNGVESSLLVYSSLMDGLCKAGNLKGGINLYRHILRSGFIPDVRVYSVLVNGLSKQGLLDDATRLFYQAVKTGLTPNIYLFNTLLDGWCRLNQLKKVANLYSQMDSYGVTPDIVTHTALSKSISQQGKVHLMLLFLFKMLKMGFSPDVVSYCTLIDGLCKHNNLTAGLQVFSLMVKNGVNPDIAIYNVLIHAFFNEGRLGNALELFRQVSRCGPEPDIVTYNTVIYGYCSMKMLDEAIQIFEELKLRQIRFNSITLTILIDAFCKEGRLDNAMSLFSAMLETGPAPNVVTYSSLLDGLFKSFRMEDAFKLYGKMLGSNVSPNILSYSILIDGLCRRGLVQEASKTFSSALSKGLLPDVVAYGILIRGYCKVGRLVEALCLYNRMLVDGIVPDSVINMTLKEFQLENLLGKSTCTPLQELNRSYCLAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2D6</accession>
    <name>A0A068V2D6_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Switch 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00042266001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739175">
        <property type="protein sequence ID" value="CDP14806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2D6"/>
    <dbReference type="FunCoup" id="A0A068V2D6">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2D6"/>
    <dbReference type="Gramene" id="CDP14806">
        <property type="protein sequence ID" value="CDP14806"/>
        <property type="gene ID" value="GSCOC_T00042266001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2D6"/>
    <dbReference type="OMA" id="DGVIWPY"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2D6"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="152"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="536"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP14806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="895" mass="102047" checksum="669C8B69EE2B4B7E" modified="2014-10-01" version="1">MSLSTFKETLKPCKNNPSASYSSSSSFSSISHNFDSSINPRKPPKSSLSQQLLRLQHQESTFYLPRTQLKSPKTETLLGPEAEDNDDEEEAEEEEKQDRIFRPKMESFQFDHTGPFEPLVLSLPGEISVVQVPPSINCRLLEHQRAGVKFLYNLYRNNHGGVLGDDMGLGKTIQTIAFLAAVFGKDEEADNLTSLRGNQPEKNGCVLIVCPTSVIHNWENEFSKWAPFSIAVYHGPNRDLIIDKLEAREVEILITSFDTYRIHGTILSKVQWEIVIVDEAHRLKNEKSKLYRAILEIKTQKRYGLTGTIMQNKLMELFNLFEWVVPGCLGTREHFREFYDEPLKHGQRSSAPERFIRVADDRKQHLVTVLHKYLLRRTKEETIGHLMMGKEDNVVFCAMSELQKRVYQRMLQLPDIQCLINKDLPCSCGSPLKQVECCKKIVPNGVIWPYLHRDNPDGCDSCPFCLVLPCLVKLQQVSNHLELIKPNPKDDPDKQRKDAEFAAAVFGTDIDLVGGHTQDESFMGLSNVKHCGKMRALEKLMFSWLSRGDKVLLFSYSVRMLDILEKFLIRKGCCFSRLDGSTPTGVRQSLVDDFNSSPSKQVFLISTRAGGLGLNLVSANRVVIFDPNWNPAQDLQAQDRSFRYGQKRHVIVFRLLAAGSLEELVYTRQVYKQQLANIAVSGKMEKRYFDGVQDCREFQGELFGICNLFRDLSDKLFTSEIIELHEKQGIEHGDCESSKQIFTELQKCFLPQKELTNTSAEASQNSKPKDASKEPVEPVLEDLGIVYAHRNEDIVNYGPWIQGDKELDTNLKCTVQHSLLLVARRRKSEAVAGSKNTIENAASSKMRKKSQYSLLAQFMGMEEVEFSKWLLSANPEEREKILRDYKRRKDKIPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2H7</accession>
    <name>A0A068V2H7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00042537001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739178">
        <property type="protein sequence ID" value="CDP15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2H7"/>
    <dbReference type="FunCoup" id="A0A068V2H7">
        <property type="interactions" value="1439"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V2H7"/>
    <dbReference type="Gramene" id="CDP15010">
        <property type="protein sequence ID" value="CDP15010"/>
        <property type="gene ID" value="GSCOC_T00042537001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2H7"/>
    <dbReference type="OMA" id="PEDQHIQ"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2H7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033575">
        <property type="entry name" value="DDA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018276">
        <property type="entry name" value="DDA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31879">
        <property type="entry name" value="DET1- AND DDB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31879:SF2">
        <property type="entry name" value="DET1- AND DDB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10172">
        <property type="entry name" value="DDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="197" mass="21805" checksum="3576E940845AC9BE" modified="2014-10-01" version="1">MEGSSALPSDSNNQNPMGGAAEFLSNLPSRGLFSSTVLSSNPGGMRVYICDHDTAPPAEQLIKTNQTNILIRSLMLKKQKGDSGSKDGKANASNESSRKRTADRALDSRAKRAMTISQVASRQEGSKSRLPERDLQSLTVERIRALLKERGLSLKGRKASILLLLIEIKSDSPRIQCHLHRPSLAFWLRDLFLKFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V2V1</accession>
    <name>A0A068V2V1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00042295001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739176">
        <property type="protein sequence ID" value="CDP14829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V2V1"/>
    <dbReference type="STRING" id="49390.A0A068V2V1"/>
    <dbReference type="Gramene" id="CDP14829">
        <property type="protein sequence ID" value="CDP14829"/>
        <property type="gene ID" value="GSCOC_T00042295001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V2V1"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V2V1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF211">
        <property type="entry name" value="ABC TRANSPORTER A FAMILY MEMBER 7-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP14829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="127" mass="13712" checksum="004BA6CC555CDEFE" modified="2014-10-01" version="1">MGKAICSYLKVEHLLNEPGTSYPIISYRLQKTCPARDGNPEKQAVKGLFLVVARGECFGLLGPNGAGKTSFISMMTGLTKPSSGTAYVGGLKLKTQMGEIHSSMGVCPQENLLWDTLTGREHLNFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V4I1</accession>
    <name>A0A068V4I1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00015323001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. HSP26 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG739184">
        <property type="protein sequence ID" value="CDP15482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V4I1"/>
    <dbReference type="STRING" id="49390.A0A068V4I1"/>
    <dbReference type="Gramene" id="CDP15482">
        <property type="protein sequence ID" value="CDP15482"/>
        <property type="gene ID" value="GSCOC_T00015323001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V4I1"/>
    <dbReference type="OMA" id="AFANDNN"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V4I1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000012">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF676">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="88"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP15482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="224" mass="26044" checksum="50A1B5E23E66D8F8" modified="2014-10-01" version="1">MSGEDLKLLGTRSSSFVWRTVWALKIKGLEYTYIEENLYNKSSLLLELNPVYKKVPVLVHRGKPICESLVIIEYIDETWKENPILPEDPLERAYARFWAKFSDEKLAESAGQVLRTTGEEQAKALERMTEAMEILEREISGKKFFGGDKIGYLDIVIGWSAYWLQFLEEVGCFKAMDSTKYPCLHLWMKNFIEFPLIKKNLPTPDELLSTFRPYRNMILARTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5P4</accession>
    <name>A0A068V5P4_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00016787001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be a cell surface adhesion protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fasciclin-like AGP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739196">
        <property type="protein sequence ID" value="CDP15882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5P4"/>
    <dbReference type="FunCoup" id="A0A068V5P4">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5P4"/>
    <dbReference type="Gramene" id="CDP15882">
        <property type="protein sequence ID" value="CDP15882"/>
        <property type="gene ID" value="GSCOC_T00016787001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5P4"/>
    <dbReference type="OMA" id="YHIIPKY"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5P4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009834">
        <property type="term" value="P:plant-type secondary cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000006">
        <property type="entry name" value="Fasciclin-like arabinogalactan protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045003">
        <property type="entry name" value="FLA_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32077">
        <property type="entry name" value="FASCICLIN-LIKE ARABINOGALACTAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32077:SF54">
        <property type="entry name" value="FASCICLIN-LIKE ARABINOGALACTAN PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655551" description="FAS1 domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="12">
        <location>
            <begin position="38"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDP15882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="249" mass="26481" checksum="F69B43B9ABCB7BAE" modified="2014-10-01" version="1">MARTALSQLLALAPLLFLLLLRINAQSSTAPAPAPEGPINTTGILDKAGGFSTLIRLLDETQAGNQIDNQLNNSHDGMTLLAPTDNAFQNLPAGALNKLSDQQKVQLIQYHVIPKYYTLTSLQTVSNPVRTEASGQDGGVFGLNFTGQTNQNQVNVSSGTVNTPIYNVVRGKFPLAIYQLDKVMWPMEFNESKASAPVSSPPTLNSTRSGSGDGNTTAETPSTKSDAKSMTVGLSLISGLWLLCMGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V5U7</accession>
    <name>A0A068V5U7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00017042001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739199">
        <property type="protein sequence ID" value="CDP16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V5U7"/>
    <dbReference type="FunCoup" id="A0A068V5U7">
        <property type="interactions" value="1958"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068V5U7"/>
    <dbReference type="Gramene" id="CDP16041">
        <property type="protein sequence ID" value="CDP16041"/>
        <property type="gene ID" value="GSCOC_T00017042001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V5U7"/>
    <dbReference type="OMA" id="ESNVPQF"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V5U7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF24">
        <property type="entry name" value="PROTEIN PAT1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="104911" checksum="460E0F0DEFBE9443" modified="2014-10-01" version="1">MERSDSKDFPDASSSSSSSAAPASASSFSENALFDASQYAFFGKDIVEEVDLGGLEEEYDDSASIPVLGGFGARDDDLQEYHLFDKDEGSGLGSLSDMDDLATTFSKLNRVVTGPRHPGVIGDRGSGSFSRESSSAAEWVQESDFPEWRDHMSDSEFYPEGKRWSSQPQLSSGKPLYRTSSYPLQQQQLQRTSSYPQQQPQLQHFASEPIIVPKSSFTSFPPPGGRSEQASPSGYSPHMNISSLASGSHSPFSAPNVSHLSNSNMHLAGLPHGFPYGRNMAQLTPLNARSQNQWTGPGNLFDGGHSNMLNSFLYQQLPFQNGLLPPHLMSTQQQLQQARLHLSVQPSVAHFSALRSQLYNSFPSPAHLSKYGLANMKDSRPKSTKKGKHNVRFSQQGSDAGSQRSDSNWPQFRSKYMTADEIESILKMQHSAAHSNDPYVDDYYHQARLAKKAAELGSEHRFCPAQTRESSSRSRNSTESQPHLHVDALGRVSFSSVRRPQPLLEVDPPASACGDGTGEQKTSDKPLEQEPMLAARITIEDGLYLLLDVDDIDRLLQFSQPQDGGAQLRRRRQVLLEGLAASLQLVDPLGKSGSSAGLAPKDDIVFLRLVSLPKGRKLISRFIQLLFPGVELARIVCMAIFRHLRFLFGGLPSDSEAAETIINLAQTVSACVSGMDLNSLSACLAAVVCSSEQPPLRPLGSAAGDGASIILKAVLERATHLLTESKAAGNYSIPNPALWQASFDAFFGLLTKYCLSKYDSIVQSIFNQNQPDAEMNVPEAARAVSREMPVELLRASLPHTDERQRKLLLNFAQRSMPLTGFNAHGGSSGQINPESVKEGYHNALVSFLWPRLQHDIPPCLPSLFLSPPYLSLSLSSHFPSSLSLFPAYSDEHIVVINCVICCKILKGFRNEIFFIQGALFLCSHDPHEPCIDKGSQGMKKEESYSSAVPDSIAKMKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068V950</accession>
    <name>A0A068V950_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSCOC_T00004932001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739228">
        <property type="protein sequence ID" value="CDP17029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068V950"/>
    <dbReference type="STRING" id="49390.A0A068V950"/>
    <dbReference type="Gramene" id="CDP17029">
        <property type="protein sequence ID" value="CDP17029"/>
        <property type="gene ID" value="GSCOC_T00004932001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068V950"/>
    <dbReference type="OMA" id="CENPLGG"/>
    <dbReference type="OrthoDB" id="549353at2759"/>
    <dbReference type="PhylomeDB" id="A0A068V950"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7625"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025677">
        <property type="entry name" value="OST-HTH-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF90">
        <property type="entry name" value="EMB|CAB71880.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14418">
        <property type="entry name" value="OHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7625" evidence="3">
        <location>
            <begin position="366"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="OST-HTH associated" evidence="2">
        <location>
            <begin position="488"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDP17029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="58571" checksum="24461D82A1E9A206" modified="2014-10-01" version="1">MEKGGGGGGGGAAEGQYSAAKTSVWWDIENCQVPRGCEAHVIAQNISSALVKLDYCGPVSISAYGDTNRIPSSVQQALSSTGIALNHVPAGAKDASDKKILVDMLFWAVDNPAPANYLLISGDRDFSNALHQLRMRRYNILLAQPLQASAALAAAAKSVWRWTTLVSGGSPLTPAELGNMSRHDSSPASLSDSTIPDARLSTKFVIKDPPSQLYIARASSMPSRMHENSGTDYSQQLESHPEIQFKKAPHEFFGFSSVSPSSRLDGIRNTAASFPNPTDIAKLNLLDCPKNAANSNQPNSVKCSGLASSYGAHSSSGVALHAGPPTYYYNSADNKYNQNPALPCPISPSVTLTPRAAPSNGSVWGSEGCQPPPDYARGLVGVILLALNTLKVEKIIPSEANITSCIRYGNPKFRNIDVRKALDFALEQQMIVKQNLGDVQLYVGRLERLWKCVNPIDSNTKQYPKLMWDVIQQFLASSYGRSALMASESRYEAALTLKSACLKDLSLGEVLQVLYMVINVKRWVIAAQSGWQPITVTLPENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VB51</accession>
    <name>A0A068VB51_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00003898001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739264">
        <property type="protein sequence ID" value="CDP17779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VB51"/>
    <dbReference type="FunCoup" id="A0A068VB51">
        <property type="interactions" value="1712"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VB51"/>
    <dbReference type="Gramene" id="CDP17779">
        <property type="protein sequence ID" value="CDP17779"/>
        <property type="gene ID" value="GSCOC_T00003898001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VB51"/>
    <dbReference type="OMA" id="QQFVSHI"/>
    <dbReference type="OrthoDB" id="1893723at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VB51"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37745">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37745:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP17779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="680" mass="76734" checksum="5ADDE4C1DF016145" modified="2014-10-01" version="1">MNPSKVEDEIFNHHHHHSHLGPPHHIIVDHHHHHHGQSQPSVSVFDGEQPDDEAFHFEMGLFREDDEDDISQNSSDAEIPQIQPSLNPNLPTPPPPLSPNPNPNNPSGSNTNGVGKVNHHNHNHSRDHHAPPATYISPEPHISSQFYTFNKESHALMLQCLREGRPATPEEIRAATPVPVLSSWRSVWKDRNEDTAYLTAWKRIQDKLNIHVNPTNGNEFLCFKNNSNQFVSHVDQWQDIVMNFHCDADFKHLGLKETVDRIKQTWTVGAKFYGIPESYIRTCVSACPICSDESSGCAPRNKRRRFEYTESFEVPAKEVPARLQQLAAKHKVVLCIRQKYIRYKPFMAEVKDYACHRAGEPASSKKSRILKREPYASKRCGCGFRIRAIVPISNYNEKDKTFVYEEEGTAVFKLYAKHSGHEPGPLDGNARIMHRVVGHKGGVMMDQDAVYGMGEEAENETFGFLGKDDGDLQQAVFQQAQELRNEVGLLEAKIGKLPAELLSSVSRDLFDIVHKLRNVGDYGPKSLDLLSDKHDSDGVLVGENDLAEWTEHHHQRLYGDGKDVDLLDDDEDSFGRTLGDVVPWDPMRTDCRTEKDLLSETCKAEKWLNPGEFDEKSILDCGDSKLTKPLRHDETIDPDVGLALQVDNFYPENPKWFDSPCGLDSGADCGDGEFRPGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VBG3</accession>
    <name>A0A068VBG3_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00003680001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739287">
        <property type="protein sequence ID" value="CDP18066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VBG3"/>
    <dbReference type="Gramene" id="CDP18066">
        <property type="protein sequence ID" value="CDP18066"/>
        <property type="gene ID" value="GSCOC_T00003680001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VBG3"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="77" mass="9390" checksum="9BB88F52A752BBA1" modified="2014-10-01" version="1">MLLFLAVVLKHYGNALQLSKMDWESKEAIFWVWWKKLKRSYKRKREFRHIAITTNILWQILLARRSILKLADECDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VC41</accession>
    <name>A0A068VC41_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KIB1-4 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012028001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="49390.A0A068VC41"/>
    <dbReference type="Gramene" id="CDP18296">
        <property type="protein sequence ID" value="CDP18296"/>
        <property type="gene ID" value="GSCOC_T00012028001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VC41"/>
    <dbReference type="OMA" id="PEFMAMA"/>
    <dbReference type="OrthoDB" id="1863935at2759"/>
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    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40891">
        <property type="entry name" value="DUF295 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40891:SF1">
        <property type="entry name" value="DUF295 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIB1-4 beta-propeller" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="170" mass="19507" checksum="F45162DA0B50F06A" modified="2014-10-01" version="1">MNGKMYGLMLQSHALVTLDFVGPTVLLRHIIKDGSPFQLPCPLPLENSFYDKYLIKSSGELLFVFKIYSAPGNYTVAYFKVFRVNTSEIVCEEVKNLGDQLVFLNHHYGMTCSIQEPGIRRNSIYFAELFDRNLYVYNMENRSQSVKLPCPIAKRKARLSWVMPLLPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VCP5</accession>
    <name>A0A068VCP5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00010853001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739312">
        <property type="protein sequence ID" value="CDP18347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VCP5"/>
    <dbReference type="Gramene" id="CDP18347">
        <property type="protein sequence ID" value="CDP18347"/>
        <property type="gene ID" value="GSCOC_T00010853001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VCP5"/>
    <dbReference type="OMA" id="EMPGSEM"/>
    <dbReference type="OrthoDB" id="10259977at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VCP5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990585">
        <property type="term" value="F:hydroxyproline O-arabinosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056508">
        <property type="entry name" value="HPAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF36">
        <property type="entry name" value="HYDROXYPROLINE O-ARABINOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23452">
        <property type="entry name" value="HPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Hydroxyproline O-arabinosyltransferase-like" evidence="7">
        <location>
            <begin position="69"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP18347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="364" mass="41746" checksum="31B95ECBB2727FC6" modified="2014-10-01" version="1">MGRATPVLLVLLSLGFFFVTYNLITTIVHYRAVGSGKQTVSTRETPSLIDPVIQMPLYARKAKKERLLFHVALTATDAPYSKWQCRIMYYWYKKKKDLPGSEMGKFTRILHSGSPDNLIDEIPTFVVDPLPKGLDQGYVVLNRPWAFVQWLEKATIDEEYILMAEPDHIFLNPLSNLAHHEFPAAFPFFYIKPTENEHIIRKFFPEESGPVSNVDPIGNSPVIIKKDLLEKISPTWMNVSLRMKNDAETDKTFGWVLEMYAYAVASALHGVQHILWKDFMLQPPWDLETRKKFILHYTYGCDYNMKGELTYGKIGEWRFDKRSHLTGPPPKNISLPPPGVPESVVTLVKMVNEATANLPNWETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VD21</accession>
    <name>A0A068VD21_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CCR4-NOT transcription complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00003216001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A068VD21">
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    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VD21"/>
    <dbReference type="Gramene" id="CDP18464">
        <property type="protein sequence ID" value="CDP18464"/>
        <property type="gene ID" value="GSCOC_T00003216001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VD21"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VD21"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="750"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="575"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="669"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDP18464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="97573" checksum="1AEE79950513FC1D" modified="2014-10-01" version="1">MGASRKLQGEIDRVLKKVQEGVDVFDSIWNKVYDTDNANQKEKFEADLKKEIKKLQRYRDQIKTWIQSSEIKDKKVSASYEQALMDARKQIEREMERFKICEKETKTKAFSKEGLGQQPKTDPKEKAKSDTRDWLNNVVSELENQIDSFEAEIEGLSVKKGKTRPPRLTHLETSIARHKAHIMKLELILRLLDNDELSPETVNDVKDFLDDYVERNQEDFDDFDDVDELYSSLPLDKVESLEDLVTIGPPGLVKGVSASNAVLSMKNHLATPAAQVPATATSANQQGASPQEQVEETATQDTTDTVARTPPPKSSSAAASAPPTPVGSHSNPGIVKATSDFVGASTASSGHLGSSSSTGLLDNAGVPSSPVSVPYSVKEEDITSFPGRKPSPALAEVGLRGVGRGGLSNQPSSSVPISSGSTISSNGALGSVTSGSEMAKRNMLGAEERLGSSSMVQSLVSPLGNRMILPQAGKTGDGIGSADAGSVGEAASMAGRVLSSSVVHGIQWRPGSSFQNQNEVGQFRGRTEIAPDQREKFLQRFQQVQQGQTNLLGLPLSGGNHKQFSAQQQNSLLQQFNSQSSSISPQLGVQPAGLNSVPSSPSLQQQPIPIHQSSSQQTQILAGSRDADVGHAKVEELHQQPAVSEDSSESIGNSGLVKNLMNEDDMKASYALDPPAGAGSALTESSQMPRDIDLSPSQPLQSSQPSGSLGVIGRRSVADLGAIGDNLSVSPATSGGMHDQLYNLQMLESSFYKLPQPKDSERAKSYTPRHPVVTPPSYPQVQAPIVNNPAFWERLGADNYGTDTLFFAFYYQQNTYQQYLAAKELKKQSWRYHRKYNTWFQRHKEPDIATDDYEQGTYVYFDFHIGNDEQHGWCQRIKTEFTFEYNYLEDELIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VDH9</accession>
    <name>A0A068VDH9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSCOC_T00010372001</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739343">
        <property type="protein sequence ID" value="CDP18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VDH9"/>
    <dbReference type="FunCoup" id="A0A068VDH9">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VDH9"/>
    <dbReference type="Gramene" id="CDP18619">
        <property type="protein sequence ID" value="CDP18619"/>
        <property type="gene ID" value="GSCOC_T00010372001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VDH9"/>
    <dbReference type="OMA" id="ACIKSNP"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VDH9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000177">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase At1g17230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000544">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000445">
        <property type="entry name" value="MDIS1-interacting receptor like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF163">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658527" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="31"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="859"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDP18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123971" checksum="E042023B953884A4" modified="2014-10-01" version="1">MKVIMGSFKIISTFLLVLLLFPSFQPKCGASASAEEAAALLKWKASFQNQNNSFLTSWNLQSINTKKSSVLPCTWAGISCIDGSVNRLNLSDWSIEGSLYDFPFSSLPNLEYLDLSQNQIFGSIPKQIGNLSKLSYLNFYANELSQEIPPEICNLTNLTHLDFGSNQLSGPIPVAMGNLISLQFLSLCQNNLTGAIPKSLGNLTNLIILYLYKNQISGSISKEIGDLKFLTHMELGENQLNGSIPVSIGNLRNLKVLSLRNNQFSGSIPATFGYLNRLMDLGLYQNHLSGPIPPAIGNLISLQFLYLYQNNLTGAIPNSLGNLTNLIELDISENQLNGSIPASIGNLSTLKLMYLHNNQFFGLIPATFGSLNRLVNLSLGQNHLSSPIPPMIGNLISLQFLYLYQNNLTGAITKSLDNLANLIELDLSFNQLSSSIPISIGNLSNLEFLSLGQNQCFGTIPQELGNLNKLVDLRLFSNQFSGPLPELLCQSGILQNITVDENMLTGPIPKSLQNCSSLFRARFDGNHFQGNISEMFGIYPVLDFIDLSNNQFYGKLSSNWGKCKMLKALIVAKNNITGGIPPEIGNLTQLHKLDLSSNYLSGEIPTGVGKLASMIKLDLHGNQLTGGIPQELGMLMEFLDLSTNSLNGTLPELLGDLKDLFHMNLSNNVLSQKIPLQIGKLTQLSELDLSQNLFTGEIPSEFQNLQSLGTLDLSQNNLSGLIPKVLAELPGLLHINLSFNNLDGPIPSGRAFVNLTLEEVKGNKGLCGTITGLRACESSQLIKKHVKDKRKEFVLITALPLLGSFILLGAFFGVLRLSGRRKQNSGVQDTEVNKGGLFAICAYEGKALYKEIVRSTEEFSQTYCIGKGGCGSVYKAQLPSGEVVAVKRLHNIPNVAKDRSFLNEIRALTEIKHRNIVKLFGFCSNAQHSILVYEYLERGSLAKILSIEEEAKELDWQERLNIIKGVAHALSYMHHDCSPPIVHRDISSNNILLDPECEAHVSDFGTAKFLRRDSSNWSSLAGTYGYVAPEFAYTMKVNEKCDVYSFGVLTMEVIKGKHPGDLIANLMSSKLEEIELKVLLDKRLLYPNRQIEESLLSILKLARECLHVDPQCRPTMLIISRLISTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFA8</accession>
    <name>A0A068VFA8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00012964001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739315">
        <property type="protein sequence ID" value="CDP18383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFA8"/>
    <dbReference type="FunCoup" id="A0A068VFA8">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP18383">
        <property type="protein sequence ID" value="CDP18383"/>
        <property type="gene ID" value="GSCOC_T00012964001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFA8"/>
    <dbReference type="OMA" id="LKHDDDQ"/>
    <dbReference type="OrthoDB" id="1932414at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFA8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36795">
        <property type="entry name" value="OS01G0938400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36795:SF2">
        <property type="entry name" value="OS01G0938400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP18383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="134" mass="15922" checksum="589C8D6C1DC67E8D" modified="2014-10-01" version="1">MGSTFTSSFSYQRLKEERWFDDDFDEHIGRLRHSSTFRLRRVHVRRRLKVKIPSLRRFLRRKARSVKLAWTKVVKRLKESQSHFGDLFAGNYLFLQVTPTPLKSNNNVHKSLKPYCINHDLAPTSIYSLPKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VFC2</accession>
    <name>A0A068VFC2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_479</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00007340001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739563">
        <property type="protein sequence ID" value="CDP19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VFC2"/>
    <dbReference type="STRING" id="49390.A0A068VFC2"/>
    <dbReference type="Gramene" id="CDP19426">
        <property type="protein sequence ID" value="CDP19426"/>
        <property type="gene ID" value="GSCOC_T00007340001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VFC2"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VFC2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="75" mass="8842" checksum="56FFAB74E934F681" modified="2014-10-01" version="1">MKQPFSQSEVKCLMLQLLEGVKYFHDNWVLHRDLKTSNILLNNCGELKLCDFGLARQYGSPLKPYTHLVVTLWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VH44</accession>
    <name>A0A068VH44_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00013425001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739924">
        <property type="protein sequence ID" value="CDP20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VH44"/>
    <dbReference type="STRING" id="49390.A0A068VH44"/>
    <dbReference type="Gramene" id="CDP20031">
        <property type="protein sequence ID" value="CDP20031"/>
        <property type="gene ID" value="GSCOC_T00013425001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VH44"/>
    <dbReference type="OrthoDB" id="1564807at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VH44"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="114" mass="12765" checksum="ABF5FD0A920DEF1F" modified="2014-10-01" version="1">MNCDRIEVGEMLQVALLCTQYLLAHRPKMSDVVRMLEGEGPPEKWAASHNYTNQGTNVPPLIHGSGIRLHHATVPGHDDNVYDQSAMFKMITMDEDYGALWSEITRGPKNAQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VHR5</accession>
    <name>A0A068VHR5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00006635001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739453">
        <property type="protein sequence ID" value="CDP19178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VHR5"/>
    <dbReference type="FunCoup" id="A0A068VHR5">
        <property type="interactions" value="1099"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VHR5"/>
    <dbReference type="Gramene" id="CDP19178">
        <property type="protein sequence ID" value="CDP19178"/>
        <property type="gene ID" value="GSCOC_T00006635001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VHR5"/>
    <dbReference type="OMA" id="HANDKCK"/>
    <dbReference type="OrthoDB" id="621266at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VHR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000031">
        <property type="entry name" value="DUF642 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000091">
        <property type="entry name" value="DUF642 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006946">
        <property type="entry name" value="DGR2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052437">
        <property type="entry name" value="Pectin_Meth_Modulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31265:SF1">
        <property type="entry name" value="OS01G0756600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31265">
        <property type="entry name" value="OS02G0527500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04862">
        <property type="entry name" value="DUF642"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001658943" evidence="6">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="DUF642" evidence="7">
        <location>
            <begin position="31"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF642" evidence="7">
        <location>
            <begin position="200"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP19178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="394" mass="43267" checksum="8F4C2DE14BC01D2B" modified="2014-10-01" version="1">MIWSSRSCKRVFVFVVLLASSAAVALIEDGSLVNGDFETPPPGGFSPDAQFPDGPATIPSWKSNGTVELVESGQKQGGMILIVPQGTHAVRLGNDAEISQEVKVEKGSIYSVTFSAARTCAQLESLNVSVPPASQTIDLQTLYSVHGWDSYAWAFQADEDDVRVVFKNPGMEDDPTCGPIIDDIAIKKLFVPDKSKDNAVLNGDFEEGPWMFRNASLGVLLPTNLDEETSSLPGWIVESNRAVRYIDSYHFTVPEGKRAIELLSGKEGIISQMVQTKPNQHYRLTFSLGHAGDSCKQPLAVMAFAGDQAQNIHYTPDSNSTFQSANLNFTAKAERTRVAFYSIYYNTRTDDMSSLCGPVVDDVRVEKSGSRDIKLQGFRLTMCLFLHFFLLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIF8</accession>
    <name>A0A068VIF8_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00005786001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739587">
        <property type="protein sequence ID" value="CDP19458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIF8"/>
    <dbReference type="Gramene" id="CDP19458">
        <property type="protein sequence ID" value="CDP19458"/>
        <property type="gene ID" value="GSCOC_T00005786001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIF8"/>
    <dbReference type="OMA" id="HPHEKEY"/>
    <dbReference type="OrthoDB" id="1720991at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIF8"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053098">
        <property type="entry name" value="Petuviruses_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028919">
        <property type="entry name" value="Viral_movement"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48435:SF1">
        <property type="entry name" value="POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01107">
        <property type="entry name" value="MP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP19458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="250" mass="27943" checksum="1E30356213660CE9" modified="2014-10-01" version="1">MATSSRSTSIASGLKIETIHSNKLDYLYEVSIEPEVVNPTSIPVINPYSASEKQSFSPTRLIKSLIRAHPKGVKEYIQALKVDQHPILATRKEQFITLHIPNDFPIQWKQQGYTHIHFGAIRISLSFHGRKGLPVVARVALLDTRFRQYQHTCIATTETTLNAGTVFVTLFPNFNMSLADLHLLDALKVQLQIIGAEQVSDAIAATLHYQMVYRVQNHALNLTIPGGENALLIRVDEKNSASCTHVPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VIN5</accession>
    <name>A0A068VIN5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GSCOC_T00011150001</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG740290">
        <property type="protein sequence ID" value="CDP20444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VIN5"/>
    <dbReference type="FunCoup" id="A0A068VIN5">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VIN5"/>
    <dbReference type="Gramene" id="CDP20444">
        <property type="protein sequence ID" value="CDP20444"/>
        <property type="gene ID" value="GSCOC_T00011150001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VIN5"/>
    <dbReference type="OMA" id="KDEMECK"/>
    <dbReference type="OrthoDB" id="1741851at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VIN5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000330">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase At4g03230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021820">
        <property type="entry name" value="S-locus_recpt_kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1111">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11883">
        <property type="entry name" value="DUF3403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001655847" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="26"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="24">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="25">
        <location>
            <begin position="332"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="700"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDP20444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113542" checksum="5AF5EF5494D1BC92" modified="2014-10-01" version="1">MQTTNISLIFLVLVALVDNLQSCLARDTITFNSLLPDDGTTLISSGKRFELGFFSPEDNANTGRYVGIWYYNSSPRTVVWIANRDAPLLHVSGYFAIVEDGNLKLLDGKGASYFHTNLGSSSAVNRTLKLLDSGNLALIDGKSGNYLWQSFAEPTDTLLPGMRIDGSLKLVSWRDTGNPAAGNFTFQQDQESRLPKIMNGLRVVHWKSDQSGSVELPYFVAFFLSNFSRSGLRNPSTLNYSDALASYANTRLLMNSSGQIQFYSLEQDGWSLIWSEPHDACSVYNPCGNFGSCNLRSEGLNCDCLPGFNPIFPDAWNTGDFSGGCDRKLAICSKTSKPDTFLNLKLMKVGKPDILSAGADSEDTCRQECLRNCDCQAYYYAGFNGQEGTDNGGSGCLIWTSVLTNLQEEYIDGGHNLSVRVAVSSIETTTRDCQTCGTYIVPYPLSTGPNCGDPSYYSFFCDDSTGQLFFLTSNNRYAVISINKDESRFTIQVKSQRAENCSAISGTLAGRVLQLNQSLPFDVMHHWCYYDRSDNGTSIQSGQRLQISWKPPLEPICSSSNECQDWPDSNCAATTRHEKRCLCNSNYKWDNRSLKCISAILTNPNHSEGTSLQRDKPHVAVIIVTPVIAVVLLAGSLICFCFRKRILAKRKEDKENIPMNLIPYPDDSERQSKDLVDETDKFIDVPYFSLESILAATNNFSNTNKLGRGGFGPVYKGIFPGEKEIAVKRLSSHSGQGMKEFQNEVVLIAKLQHRNLVRLLGYCIKGSEKILLYEYLPNKSLDTFIFDQGLCILLDWKLRFNIILGIARGLLYLHQDSRLRIIHRDLKTSNILLDKEMNPKISDFGLAKIVQGKETEANTIKVVGTYGYMSPEYAVKGFFSVKSDVFSFGVILLEIISGKRNSAGFYQSEGALSLLGYAWRLWQERKSIDFVDKKILESCNETEVIKCINIGLLCVQDDPSERPSMSDILIMLSSETTALPTPNQPAFVVRRHTSKTPALSRKERTNSINEITISVEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VJ17</accession>
    <name>A0A068VJ17_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_1513</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00008003001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG740597">
        <property type="protein sequence ID" value="CDP20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VJ17"/>
    <dbReference type="STRING" id="49390.A0A068VJ17"/>
    <dbReference type="Gramene" id="CDP20671">
        <property type="protein sequence ID" value="CDP20671"/>
        <property type="gene ID" value="GSCOC_T00008003001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VJ17"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VJ17"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="116" mass="13462" checksum="BBDC9C7588C6A772" modified="2014-10-01" version="1">MSPNLQHFHVLDGGCYLSKVIFHVYLGSFTKISCSQFSSKSWLQEALEPAFQRDGQRIGTEIWRIENFQPIPLRKSDHCKFYLGDSYIVLQVHMASNISSFVSYFGPHFYELSVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLB9</accession>
    <name>A0A068VLB9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSCOC_T00008462001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG740337">
        <property type="protein sequence ID" value="CDP20473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLB9"/>
    <dbReference type="STRING" id="49390.A0A068VLB9"/>
    <dbReference type="Gramene" id="CDP20473">
        <property type="protein sequence ID" value="CDP20473"/>
        <property type="gene ID" value="GSCOC_T00008462001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLB9"/>
    <dbReference type="OMA" id="MARIFIG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLB9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000727">
        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057097">
        <property type="entry name" value="LysM_RLK3/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1055">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23577">
        <property type="entry name" value="LysM_RLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="339"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDP20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="656" mass="72788" checksum="C05E5684304BCFCF" modified="2014-10-01" version="1">MDNAPQNFSPLLLFPLSPNFFYQQRSLNPIMFFSSKSRTLIPRLLLLRTAILFSVQTSQVHGSCTSGCDLAQGSYYPSPGDNLTFIASLFNIPTASITDSNRANISIVPGRDNLFEGRINIPFTCDCINNNFLAHVFSYNVTSSTQTTFDTIARGSYSNLTSAAWLKRFNSYPENGVSVPRIGVLNVPVNCSCGGEVSNGYRYFVTWPVRDGETLESVAAANNLTADLVKRYNPTANFTAGNLLYIPMGVPNDSPTPALGSSKRQKSTWKLKLSIGVVAPFLATLTLLSLYCILQRKKVSGIGAISKLKRVEWSADGDKEDDESIFFSFSIIESATDHFSEARRLGQGGFGPVYKGSFNNGLEVAVKRLNKMTIYGTEQFKNEVTVISKLQHRNLVKLLGYCTHGEERILVYEYLPNKSLDSFLFDAAKQDVLDWKARLKIIEGVAQGLLYLHKYSRLKIIHRDLKPSNVLLDNDMNPKISDFGTARIFGDNELRANTSRIVGTYGYMSPEYAMDGIFSEKSDVFSFGVMILEIITGKKNTAFHDSDRHLNLIGHVWDLWIEGSLSDITDSSLNEAVPKPEALKCVQVGLLCVQEKAADRPTMSEVVSMLFNESMVLASPKRPAFSEIMSLKNANLPQNPVHCSMNKVTISEVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VLP0</accession>
    <name>A0A068VLP0_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH200=94 genomic scaffold, scaffold_4726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00013031001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG743810">
        <property type="protein sequence ID" value="CDP21534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VLP0"/>
    <dbReference type="STRING" id="49390.A0A068VLP0"/>
    <dbReference type="Gramene" id="CDP21534">
        <property type="protein sequence ID" value="CDP21534"/>
        <property type="gene ID" value="GSCOC_T00013031001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VLP0"/>
    <dbReference type="OMA" id="PLAFEMH"/>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VLP0"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDP21534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="169" mass="17947" checksum="FC6DE350C99AC90F" modified="2014-10-01" version="1">MAGQHQIWEHNTTNGVTRAFSGNGYERNLNGSSSINTSFAQPSGISLSPDLKEAYIADSESSSIRALDLKTGGSKLLAGGDPVFSENLFRFGDHDGVGSEVLLQHPLGVYCGKDGQIYLADSYNHKIKKLDPASRRVSTLAGTGEAGFRDGGALAAQVGRSFFYVSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VM16</accession>
    <name>A0A068VM16_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00010307001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG745231">
        <property type="protein sequence ID" value="CDP21736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VM16"/>
    <dbReference type="STRING" id="49390.A0A068VM16"/>
    <dbReference type="Gramene" id="CDP21736">
        <property type="protein sequence ID" value="CDP21736"/>
        <property type="gene ID" value="GSCOC_T00010307001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VM16"/>
    <dbReference type="PhylomeDB" id="A0A068VM16"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="9">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP21736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="130" mass="14924" checksum="DA420C1E02ADA4BF" modified="2014-10-01" version="1">MIKIKRERVMNLLRIPHLKHLIMQMNFQNPFCTLKHRGPVTYHTTKESLGVIILGLTDGLEQGVDLVGGYYDAGDHVKFGLPMAFTVTMLSWEMGCYNVLMGCYREMEHALEAMKWGAHTRPNVNYMLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VM55</accession>
    <name>A0A068VM55_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DH200=94 genomic scaffold, scaffold_5656</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSCOC_T00012856001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG744740">
        <property type="protein sequence ID" value="CDP21677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VM55"/>
    <dbReference type="FunCoup" id="A0A068VM55">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068VM55"/>
    <dbReference type="Gramene" id="CDP21677">
        <property type="protein sequence ID" value="CDP21677"/>
        <property type="gene ID" value="GSCOC_T00012856001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VM55"/>
    <dbReference type="OMA" id="RIMRDNC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VM55"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF39">
        <property type="entry name" value="UBIQUITIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="169"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDP21677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="251" mass="28617" checksum="2BD3E977288A2578" modified="2014-10-01" version="1">MRVTIVMGGSEFSIDVEPQETVLNIKQKIERLLSIPVASQTLAIWGWELIDGLDMEDYPIINESTKIHLNINSMPALIEEHSKIQITVKFSARKTTFEVEKTETVRSLKEKIHIIDGTPIKRMALYFSGQEMDEEFRYLTNYGISDKAEIIVFLKSTARMIADPPTRRLSLAVQTSSTLLNAATIPLDISDSSTLTELRRLLVTNKILPPDDYIFIHKQRIMRENCSLRWHGVENGDFLYVFKGTVGPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMN2</accession>
    <name>A0A068VMN2_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DH200=94 genomic scaffold, scaffold_9261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSCOC_T00000563001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG748345">
        <property type="protein sequence ID" value="CDP22035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMN2"/>
    <dbReference type="Gramene" id="CDP22035">
        <property type="protein sequence ID" value="CDP22035"/>
        <property type="gene ID" value="GSCOC_T00000563001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMN2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDP22035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="43" mass="5112" checksum="BCB9F6837F0C85D6" modified="2014-10-01" version="1">MVKYYKFPPTFLSNFHQNTFCLAYALFTYLAPRRLSTCFIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VMR5</accession>
    <name>A0A068VMR5_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH200=94 genomic scaffold, scaffold_8676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00009979001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG747760">
        <property type="protein sequence ID" value="CDP21986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VMR5"/>
    <dbReference type="Gramene" id="CDP21986">
        <property type="protein sequence ID" value="CDP21986"/>
        <property type="gene ID" value="GSCOC_T00009979001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VMR5"/>
    <dbReference type="OMA" id="IERELHM"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VMR5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP21986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="174" mass="19502" checksum="031F275E9BF65D83" modified="2014-10-01" version="1">MQQVLRTKGGEDHAIYAKNSSCQRLASIKFNSALKQSIQEFCRANLAAAAGCINIADLGCASGPNAFLAIQDIIESVDREFRESNIYLELPSIQVFLNDLVSNDFNSIFRSIAEFLSKTWGLLRTQSRVIAAMPGSFHGRLFPDNSMHFVYTSYSLHWLSQVCNLQVNEFLIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VN47</accession>
    <name>A0A068VN47_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DH200=94 genomic scaffold, scaffold_9279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00005757001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG748363">
        <property type="protein sequence ID" value="CDP22039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VN47"/>
    <dbReference type="Gramene" id="CDP22039">
        <property type="protein sequence ID" value="CDP22039"/>
        <property type="gene ID" value="GSCOC_T00005757001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VN47"/>
    <dbReference type="OMA" id="DVPANIM"/>
    <dbReference type="OrthoDB" id="1710049at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VN47"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
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    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="365"/>
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        </location>
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        <location>
            <position position="393"/>
        </location>
        <ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDP22039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="541" mass="59340" checksum="EBEAE2DB3232495C" modified="2014-10-01" version="1">MLELSNNTLSGRLPSSTGYGLINLEWLDLFLNELDGVIPASISNASKLTVLELGQNRFCGPVPNSLGNLRLLRHLELTGNHLSGPVPSTMEYLQNLQALFLGDNQLSGSIPDCICRLKRLYQMYVGQNIFRGSIPSCLNNISSLGEIDFAGNLLNSSIPGSLWNLTDLLKLNLSYNSLSGSLPYETGNLKVVTLLDLSGNHLNGNIPSSLGGLQRLAKLSLAQNKLQGPVPDSLNQMFSLEFLDLSNNNLSGPIPKSLETLIYLNYINLSFNHFRGEIPSSGPFKKFHVPPCRSPRIHKSSQKKVFHMLGILSGIAATIIAVTAAAILLLRRPRNDGVSRNTDLLPMGLPKRISYSELVQATNGYDERNLLGKGSFGSVYKGILTDGTVVAVKVFTLLADVNSRSFDTECEVLRNLRHRNLTKVIGSCSNLDFKALVLEYKSNGSLEKWLYSHNHCLDLLQRISTMMDVASALEYLHFGYTAPVVHCDLKPSNILLDESMVAHVSDFGMAKFLDEEDSVLHTKTLATLGYLAPGLAYLTSF</sequence>
</entry>
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    <accession>A0A068VNA2</accession>
    <name>A0A068VNA2_COFCA</name>
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        <submittedName>
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    </protein>
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    <organism evidence="7 8">
        <name type="scientific">Coffea canephora</name>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>Coffea</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">cv. DH200-94</strain>
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    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DH200</strain>
        </source>
    </reference>
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        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A068VNA2"/>
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        <property type="protein sequence ID" value="CDP16970"/>
        <property type="gene ID" value="GSCOC_T00004798001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP16971">
        <property type="protein sequence ID" value="CDP16971"/>
        <property type="gene ID" value="GSCOC_T00004799001"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP22094">
        <property type="protein sequence ID" value="CDP22094"/>
        <property type="gene ID" value="GSCOC_T00005086001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNA2"/>
    <dbReference type="OMA" id="CANSDAA"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
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        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
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        <property type="entry name" value="Small_HSP"/>
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    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
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        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDP16970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDP16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDP22094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="138" mass="15637" checksum="86F01B7D9B22A054" modified="2014-10-01" version="1">MSLIPSVFGGRRSNVFDPFSLDIWDPFEGFPFSNTSLANVPDTARDTSAFATARIDWKETPEAHVLQISGERSREQEEKNDKWHRVERSSGRFLRRFRLPENAKVDKVKASMENGVLTVTVPKEEVKKADVKAIEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068VNC4</accession>
    <name>A0A068VNC4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DH200=94 genomic scaffold, scaffold_2709</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSCOC_T00003623001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
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                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG741793">
        <property type="protein sequence ID" value="CDP21183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068VNC4"/>
    <dbReference type="STRING" id="49390.A0A068VNC4"/>
    <dbReference type="Gramene" id="CDP21183">
        <property type="protein sequence ID" value="CDP21183"/>
        <property type="gene ID" value="GSCOC_T00003623001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068VNC4"/>
    <dbReference type="OMA" id="QFSSHAY"/>
    <dbReference type="OrthoDB" id="1721266at2759"/>
    <dbReference type="PhylomeDB" id="A0A068VNC4"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001656103" evidence="10">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDP21183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="297" mass="33034" checksum="84A072409B533737" modified="2014-10-01" version="1">MWAFWTSTLANVFLLLQFAMRFPAIHVSLSAAKQFQNETDRLALLEFKHQIYDDPFGVLNSWNHSQYHCQWEGVTCSTRHQRVVALTLMDRQLSGTISPHVGNLSFMRFIQLGENQFHGEIPQEFGRLFRLRVLNLLKIFIFHTNNLTGEIPSSIGNLSSLTTLALGYNNLEGNLPSEMGLLKKFAILTAGGNKLSGIIPASIFNCSAIIAISVPANSFHGNLPTNIGLTLPNLEGLYLGANKFYGNFPTSITNASGLEVLDLSRNKFEGQIPANLGDLTNLIVFDLYDNLFGNLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-24" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2TM26</accession>
    <name>Q2TM26_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STO-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00034292001</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2006" name="J. Plant Physiol." volume="163" first="691" last="708">
            <title>Oleosin gene family of Coffea canephora: quantitative expression analysis of five oleosin genes in developing and germinating coffee grain.</title>
            <authorList>
                <person name="Simkin A.J."/>
                <person name="Qian T."/>
                <person name="Caillet V."/>
                <person name="Michoux F."/>
                <person name="Ben Amor M."/>
                <person name="Lin C."/>
                <person name="Tanksley S."/>
                <person name="McCarthy J."/>
            </authorList>
            <dbReference type="PubMed" id="16442665"/>
            <dbReference type="DOI" id="10.1016/j.jplph.2005.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope - CEA"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DH200</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Structure and adaptive landscape of the coffee genome.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DH200</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AY841276">
        <property type="protein sequence ID" value="AAX49394.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG739090">
        <property type="protein sequence ID" value="CDP00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2TM26"/>
    <dbReference type="FunCoup" id="Q2TM26">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="49390.Q2TM26"/>
    <dbReference type="Gramene" id="CDP00863">
        <property type="protein sequence ID" value="CDP00863"/>
        <property type="gene ID" value="GSCOC_T00034292001"/>
    </dbReference>
    <dbReference type="InParanoid" id="Q2TM26"/>
    <dbReference type="OMA" id="VLNWTFR"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF14">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY PROTEIN 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAX49394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDP00863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="356" mass="40050" checksum="49E9C658E1172017" modified="2006-01-24" version="1">MDLINSVLNLVVPPASLLMLAFAWPTLSFINACEWLYNTYFSEEMDNKVVVITGASSGIGEQIAYEYAKRGANLVLVARRDNRLHGIADNAQRLGSRHVLIMAADVVKEEDCRRFINETINYFGCVDHLVNTASLGHTFFFEEATDASVFPILLDINFWGNVYPTYVALPYLRQTNGRIVVNASIENWLPLPRMSLYSAAKAALINFYETLRFEVKDEVGITIATHGWIGTEMTRGRFMVEEGAEMQWKEEREVQVTGGPAEDFAKLIVAGACRQAAYVKYPSWYDIFFVFRVFSPNVLYWTFHLLSTSHVSRRTSFIGTGRPLLEGSPPRKLLTGASPGTSSQSQAPVYQQQKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLM2</accession>
    <name>A0A068TLM2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSCOC_T00013977001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLM2"/>
    <dbReference type="Gramene" id="CDO96829">
        <property type="protein sequence ID" value="CDO96829"/>
        <property type="gene ID" value="GSCOC_T00013977001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLM2"/>
    <dbReference type="OMA" id="RIHYYEL"/>
    <dbReference type="PhylomeDB" id="A0A068TLM2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:response to other organism"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF585">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="413"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDO96829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="610" mass="68025" checksum="DD9471FF40ABE8D4" modified="2014-10-01" version="1">MFPHYKSIQTHKSCNFAGAIPNEIRNLTMLMILDFRSNILRGLGIPENIGNLHRLEVLVLYSNTLSGSIPTVIFNISSLQHIQLDQNKFSGTIPLTLVFLSLHHNELTGSIPTSLGSLRNLSYLNLDSNKLSMLDNNPLNGFLPASFSNYSTSLEVLSAISCKIEGNIPARISNLSSLLHLDFSSNELIGSLPRTMHSLANLQDLGLLSLSQNQIFGSIPECLGNMTNLRQIFLDSNRLTSMIPSNLLSMKDLEILNLSSNFISGSLSLEIGNLKATYDLDLSANQLAFHWQKNNLQGSIPESISNMISLEFLDLSHNNLFGVIPKSMEALKSLKECNVSFNRLSVRRSSKRKVLLLVISLSGIAAILIIAIGALLYLRWLNKPKTSGGTELMSAAKYERFSYYDLLHSTDNYNESNLLGEGSYGSVYKGILSDGTAVAIKVFNLLVEGSLKSFDRECEVLKSLCHQNLTKVLDSCSNLDFKALVLKYMPNGNLEKWLYSHNHFLDMFRRINIMIDVACALEYLHYGYDTPVVHCDLKPSNILLDEDMAAHVSDFGIAKMFGEEESILHTNTLATLGYIAPVANRVHYYYYFIYLDHYQETSSSSLIGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLT5</accession>
    <name>A0A068TLT5_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSCOC_T00014422001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO97166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A068TLT5">
        <property type="interactions" value="1784"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TLT5"/>
    <dbReference type="Gramene" id="CDO97166">
        <property type="protein sequence ID" value="CDO97166"/>
        <property type="gene ID" value="GSCOC_T00014422001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLT5"/>
    <dbReference type="OMA" id="SEECKSD"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLT5"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO97166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1996" mass="218491" checksum="4FA6A3BF77F4650F" modified="2014-10-01" version="1">MFSWNIAKSAEAMFSRWAIKRLCKFLLKKKLGKIILGDVDLKQLDVQLSAGTVKLTDLALNVDYLNHKFGAAAAVMVKEGSIGSLLLTLPWSGDGCRIEVDELELIIAPGGASVLHDGLETRNFGQNNNHPANHDSRKLENDSGSSGGVTHTSVDVHEGVKTIAKMVKWLLSSFHVKIKRLIVAFDPCIVEETNKRFSRSLVLRISEAECGTCISEDPDPHLMEEAKDNFLGLSRLTNSFEFQGAVLELLQIDDVEHQSTCACASGINFGEWFSDRCQSTAMTPIITGQNGGFSGHLKLSIPWKNGSLDICKVDVDAYIEPLELRFQPSTVAWFICLWDMFKDMGSTSGSEMLCKATDTVYDNAALNYTSSMPDVRSLNADKVLEENDNSLVNCNSLLEEECRLEALLSEFHLISDWVGRSQKDEPDFGESVYQFFECFDELRSSQSALGQSGMWNWTCSVFSAITAVSNLASGSSPIPPVQQHVETNLKVTVARISILFSFFDKKPEYSCYERENQAKAAQYVHYLDMKFLDLLLVLQVCPEEINFEATVQHIELDDHFSSENDKIDPKLQNESVTASSLTDLIQVMQDAVQDALIPFSSSGEYAGMVSRRGFDVDVQPSMVASNACSCITSCECIDMDNVVKVALFKTSGISRCQVTVSTGTSANFVLGPVSFTLSLPPCVLWANFGLVDKVSDLLKEVGACKMSHGRNNFASKTIFSEKELYSQENEEKNSHGRVSSIPSDESLRGNICLSNARIILMAGYYSFNQFLALDFSYPQKFGDKNPKASEPASGTSLSEGGLLENSKSLQLSWKDLAVYLITSDPGENGGIELSNVLKWKFSAHMIMSIANETSQLSAISMFWQDGTTGPWITRRAKLLATSGNLNNRQRFTGKDYEFASVTSAKDMEESDNRAKQEMVLSSGSFIHVLLSPVMVNLGKAHYDSLICLLHQLVNCLSCMASDTLKEESSISQTSILVDCDSVGIAVCMEEKVDTKSSTQSELPGSWHGFRLKIQKFELLSVSNIGRVRGAKFVWMSHGEGNLSGFVTGVPHEELLLISCSNSTMGRGDGEGSNVLTPRFAGSDIVHLWNPDELHSYMSIAVRCGTIVAIGGRVDWWEAISSFFSVPCREIEQTGENSLQEGGSESSAPFQTSFILNLVDIGVNYEPNMYPCASTDGLDVESSSGMVSKAADDQYIACLLAASSFTLSSNSISDSSVGVYNIRLQDLGLLLCPVSGPKTSGSNYSVEHLSRAGYVKVAHVAHVKALLKTYSKGDPRWEVESSDLRIVVGTCSDTACGLIRLGAQLQQLFAPNLEDTLVHLQTRWNDVQGTTEDAQIGTHLGGAALSDIEGQNLGANSSSCRSNLMDEICEDAFQLVGNADGQRDYDDREFNMSINDNVLGEPSELSASNGEHFAGCFPFSESNPVVGLENNGASFQHENVPEFIEEYFLSDLRPLSGVSFTSQLPNELHCKAGITGSGELPYRNNGWYGNTSLRIVENHVSEVNDQANPGQLENSESSSGCTELDDHGRIKGCILLKNMNIVWRLYAGSDWSNIQKSQEHSTSGRDATVCLEISLSRMQIQYDIFPDGGLRASQLSLAIQYIRVNDNSKNAPWKLVLGYYQSKDHPRKSSSKALKMDLESVRPDPSTPLEEYRLRVAFLPMRLHLHQSQLNFLINFFGGQRTSINSPKNGTHDMLEAGKGSHKAASLSGHTIVQEALLPFFQKFDIWPVLIRVDYVPSGVDLAALRSGKYVELVNLLTWKGVELQLKHVHSVGVYGWSSVGEMVLGEWLEDISQNQVHKLLKGLPPIRSLVAVGSGATKLVTLPVNGYRKDRRLLKGVQRGTIAFLRSISLEAIGLGVHLAAGAHDILLQAEYILTTIPPCVSCPLQSRASTSVRSNQPEDARQGIKQAYHSISDGLGKSASALVRTPLKKYQRGDGVGSALAAVVQATPVAAVAPASAAAGAMHYALLGVRNSLDPEHKKESLDKYLGSSQQREFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TLX1</accession>
    <name>A0A068TLX1_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00014133001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739085">
        <property type="protein sequence ID" value="CDO96939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TLX1"/>
    <dbReference type="STRING" id="49390.A0A068TLX1"/>
    <dbReference type="Gramene" id="CDO96939">
        <property type="protein sequence ID" value="CDO96939"/>
        <property type="gene ID" value="GSCOC_T00014133001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TLX1"/>
    <dbReference type="OMA" id="TIAQSNM"/>
    <dbReference type="OrthoDB" id="1864232at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TLX1"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008190188" description="Dirigent protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO96939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="199" mass="21798" checksum="E040CA62107F8BB6" modified="2014-10-01" version="1">MRKTTLSFLLVVFAIVMTAMAPPVHGQINPDDQSPKAVERWFKKLGHAKQEKLTKLHFYFHDILSGNKPTAVQVAQANITSKSPTLFGIVNVMDDPLTVGPEPDSRIIGSAQGLYASASQKDVGLLMTLNFVFTDGKYNGSTLSILGRNPVFHKYRELPILGGSGVFRLARGIATAKTHTFNATTGDAIVEYHVIVMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TPG2</accession>
    <name>A0A068TPG2_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSCOC_T00021886001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">cv. DH200-94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TPG2"/>
    <dbReference type="FunCoup" id="A0A068TPG2">
        <property type="interactions" value="1391"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TPG2"/>
    <dbReference type="Gramene" id="CDO97937">
        <property type="protein sequence ID" value="CDO97937"/>
        <property type="gene ID" value="GSCOC_T00021886001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TPG2"/>
    <dbReference type="OMA" id="DYWNFES"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TPG2"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38372">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38372:SF2">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCEL" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="925"/>
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        </location>
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        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO97937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="1252" mass="136522" checksum="59B8B1B2A4F7CC60" modified="2014-10-01" version="1">MYGGSGKLGRGGGGGRGGGAGAKRNIHSTFHPPPLHRPPSAAAPGGRLSMGGAGAGAGPRNRTASASAGAAAGAASSSSASASAEESFSLVTGNPLNFAMIIRLAPDLVEEIKRVESQGSVARIKFDANANNPAGNVINVGGKDFRFTWSRETGELCDIYEERQSGEDGNGLLVESGGAWRKLNVQRVLDESTKNHVKKLSEEAERKLKSRKAIVLDHGNPSMKSQMKALAAAESNPWRTKGAPFKKRNAEPPPGGPPKSVHKSGLTTTPPLKSRRPASPPSSPPEQSGAPGSPFGSGNIMKGHVNVEDFGSLQATSRTVSSDNDATGKVITSAGRGKPAQKGIKGAQPSDLRSMLISLLRESPSKGMSLKALEKAIGDTIPNSVRQIEPILKKIATFQDSGRYFLKPGVEIEGFKKASSGNQSSPEDSYHQSPAQDDRQAAPDTSFPLRSDANEMDEQAELDFKNEAAHISQEKGVLHHSYLFGDKKVSDNSEGPIGSSSDSGSDSDSESDSSDSGSDSSRSRSRSPAGSGTGSSSDSESDASTNSKEASDEDVDIMTSDDDKQAKYKLQASGLVSSRSPLLWRTSDVEPDHTGSDEKQDGHVSDVIEIEKDMPDDQPAVGMAAASISVPNKEGQKPVEQTTPSLYNHHEDQEREDHMVKIYKETGNMSRDRFNHGQSDSSEKASRGKYKRVSDEKDVENKPDRSKRFKLGNSHQTKVSPSRTTAFENSYQNSSPDRSFEELHKGHNNQMADKIKRDINSGFGSQKSHIHTSLGKSTSDSVQPIQRSADSSARAKPSASVERPGKHSEHLGRSIKHPERLHPMTEGVPVQKDKPNREMQDNYGSISYKGPGKVSKEDLGEKYTATFDSRHRKHEASGSVKDFGSVLNSNPGYPLKDENISARDRSVVNGRPNALQREFSDLELGELREPLPEETPGFRKQLDRKSSFKQLENKSLSSENGNLDSSKAKVGSKMNADSRKSSPLHTNIPFLGSSEGISNRGVHENSAEDLLRTNQRVVQSQQRHQPRVDYADAGTQHNRVVELSGKNRQGEAGRSLDATPEVQGNIPSKGLASVSQEHDAKQGAVPPSRKESRRQKSSTIPDLNDKQKDTSLTGSSDGCQKRRESSSDENSCPYSKYEKDEPELKEPIKDGFQYKEYVEEFQEKYGIYISLNKTLESYREEFLKYGRDLEASKDKDMDRYHDVERQIKESYRHCGARFKRLKKIFLVLHEELQHLKKMIHEFAAPYLKDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TR14</accession>
    <name>A0A068TR14_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSCOC_T00021709001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG739086">
        <property type="protein sequence ID" value="CDO97803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TR14"/>
    <dbReference type="FunCoup" id="A0A068TR14">
        <property type="interactions" value="2227"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TR14"/>
    <dbReference type="Gramene" id="CDO97803">
        <property type="protein sequence ID" value="CDO97803"/>
        <property type="gene ID" value="GSCOC_T00021709001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TR14"/>
    <dbReference type="OMA" id="SCDTTQD"/>
    <dbReference type="OrthoDB" id="668733at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TR14"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF482">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDO97803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="404" mass="45233" checksum="EC6CDF9582CF31F1" modified="2014-10-01" version="1">MCGGAIISDFIPPSRSSRRLTADLLWGTGADFPGTKKDINKKKKNNKKNTSDLYSKPLRSEVVDLDDEFETDFQEFNDHSDDEAEELEDVKPFGFSASKHSAIPPRGTKYGKSSDSSEESEKYSKRKRKNQYRGIRQRPWGKWAAEIRDPRKGVRVWLGTFNTAEEAARAYDTEARRIRGKKAKVNFPDETQGSASRRPVAVNPQKLQVKENPGPVQPTLSESMTFTSSMENDYYNSLNLVEEKPPTKQFGYADVYPTIGDMEFKSFPQSDCASLYFNSDQGSNSFDCSDFGWGEQCPKTPEISSILSSAIEVEESQFSEDTNPSKKLKSSLDLVPAADNDNKLSEELSAFESQMKFDQMPLFDGNWEASVDTFLNGDATQGGGNAMEDLWTFDDISAMMGGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TU42</accession>
    <name>A0A068TU42_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSCOC_T00029187001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoate by hydrolytic cleavage of the five-member hydantoin ring. Catalyzes the first step of the ureide allantoin degradation followed by the sequential activity of AAH, UGLYAH and UAH which allows a complete purine breakdown without the intermediate generation of urea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TU42"/>
    <dbReference type="FunCoup" id="A0A068TU42">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TU42"/>
    <dbReference type="Gramene" id="CDO99557">
        <property type="protein sequence ID" value="CDO99557"/>
        <property type="gene ID" value="GSCOC_T00029187001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TU42"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TU42"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056854">
        <property type="entry name" value="ALN_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24890">
        <property type="entry name" value="ALN_composite"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoinase composite" evidence="13">
        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="120"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDO99557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <sequence length="544" mass="60592" checksum="0F24E144BDC5AC7D" modified="2014-10-01" version="1">MTSVLGCRKIKHNNSTSLILNFRYSLSIISALLLLGIFYLLPFLNEFFFFFGFEQLLSANRCSLYPHSHYWIASKRIVTPRGIVSGTVEIKGGRIVSVLEEEHWQKSVKSLQVIDYGNAVIMPGLVDVHAHLDDPGKEEWEGFPSGTRAAAAGGITTLIDMPLNSVPSTVSEETLGLKLQAAAGRIYIDVGFWGGLVPENAFNASSLEGLLKAGALGLKSFMCPSGINDFPMTNISHIKEGLLVLAKYRRPLLVHAEIPQDDAGYLENKDGRDNPRSYDVYLKSRPASWEEAAIKDLLTVSKDTRTGGPAEGAHLHIVHLSDARSSFELIKEAKKSGDSMTVETCPHYLAFSAEKIPDGDTRFKCAPPIRDAANKEKLWAALIDGDIDMLSSDHSPSAPQLKLFNEGDFLRAWGGISSLQFVLPVTWSYGQKYGITLEQLASWWSEKPAKLAGLSYKGAISIGYEADFVVWEPEVEFDLDENHPVYHKHPVSSHFLTTLSVYLYDRHTACNFSLWYFFSKECTLVWHRGLECVLFYDQISLVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TUQ9</accession>
    <name>A0A068TUQ9_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSCOC_T00029747001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG739088">
        <property type="protein sequence ID" value="CDO99996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TUQ9"/>
    <dbReference type="STRING" id="49390.A0A068TUQ9"/>
    <dbReference type="Gramene" id="CDO99996">
        <property type="protein sequence ID" value="CDO99996"/>
        <property type="gene ID" value="GSCOC_T00029747001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TUQ9"/>
    <dbReference type="OMA" id="FRETHLM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TUQ9"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDO99996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48187" checksum="3205756B6D7A8E06" modified="2014-10-01" version="1">MATTFSSELLPQLFPYVTQAKLTSNCHNIFVVRCRGHIPNESKSRSPQKVMVSTEARSTQLQPHDSTEPNFLKLLSRSCKAAKYNEALYFLECMVNRGLKPDVILCTKLIKGLFSLKNAEKAVRVMHILEQYGEPDVFVYNAVISGFCKVNKTNSANEVLSRMRVRGFSADVVTYNIMIGSLCNRGKLGLALKVFDQLLQDNCKPTVVTYTILIEATALEGGIHEAMKLLDEMLRKGLQPDMYTYNAIIRGMCRGGLIDQAFHFVRSLPAKGCKPDVISYNVLLRALLNQGKWKDGEKLVAEMFSRDCEPNVVTYSILISCLCRDGKLDESLNLLRVMKDKGLNPDTYTYDPLISAFCREGRTDLALEFMDYMICNGCLPDIVNYNTILSAMCKNGNANQALELFGDLPQMGCPPDGGKLWLWRQQTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TVL7</accession>
    <name>A0A068TVL7_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSCOC_T00032170001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TVL7"/>
    <dbReference type="FunCoup" id="A0A068TVL7">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="Gramene" id="CDP00281">
        <property type="protein sequence ID" value="CDP00281"/>
        <property type="gene ID" value="GSCOC_T00032170001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TVL7"/>
    <dbReference type="OMA" id="ACIPAGY"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TVL7"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17414">
        <property type="entry name" value="MFS_NPF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012972086" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDP00281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="75590" checksum="61EFB41395441312" modified="2014-10-01" version="1">MFCLIFFFLLPSIHSGHRYIHFLIIQGNPSSHLHYLSLLSTVYSRLFLLKGLSSRRFSLSWTLSCLSTLQIKLLTFDPPPPPPLHPIPLFLSWLQFSSAAEKKEMEVENQQPGSWEGYVNWRNRPALKGRHGGMVAASFVLVAEVLENLAYLANASNLVLYFSEYMHFSPSNSANSVTNFMGTAFLLALVGGFLSDAFFTTYFIYLIGALIEFLGLVILTVQAHSPSLKPPKCDPATPSIPCQKVHGAKAAMLFIGLYLVALGVGGIKGSLPAHGAEQFDEDSPKGRKQRSTFFNYFVFCLSCGALIAVTLVVWVEDNKGWQWGFGISTFAILLSIPIFLLGSTYYRNKIPNGSPLTTIVKVLLAALLNSFKSRGSNNAIASMATSPTPTPASEEEGGNIKSKTVEPTQETPSKSLQFLNRAVGDNSTAGALDCSVQQVEEVKVVIKILPIFACTIILNCCLAQLSTFSVQQAATMNTKLGSLKVPPASLPIFPVIFMMFLAPVYDHCIIPFARRATKTEMGISHLQRIGIGLVLSILAMAVAAIVEIKRKRVAMDTGLLDTTTPLPLTFFWIAFQYLFLGSADLFTLAGLLEFFFTEAPSSMRSLATSLSWVSLAMGYYLSTVIVSIVNSATGNSNHKPWLSGSNLNHYHLDRFYWVMCVLSGLNFLHYLFWAMRYKYRSGRAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TW28</accession>
    <name>A0A068TW28_COFCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleobase-ascorbate transporter 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSCOC_T00032072001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coffea canephora</name>
        <name type="common">Robusta coffee</name>
        <dbReference type="NCBI Taxonomy" id="49390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>asterids</taxon>
            <taxon>lamiids</taxon>
            <taxon>Gentianales</taxon>
            <taxon>Rubiaceae</taxon>
            <taxon>Ixoroideae</taxon>
            <taxon>Gardenieae complex</taxon>
            <taxon>Bertiereae - Coffeeae clade</taxon>
            <taxon>Coffeeae</taxon>
            <taxon>Coffea</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Science" volume="345" first="1181" last="1184">
            <title>The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.</title>
            <authorList>
                <person name="Denoeud F."/>
                <person name="Carretero-Paulet L."/>
                <person name="Dereeper A."/>
                <person name="Droc G."/>
                <person name="Guyot R."/>
                <person name="Pietrella M."/>
                <person name="Zheng C."/>
                <person name="Alberti A."/>
                <person name="Anthony F."/>
                <person name="Aprea G."/>
                <person name="Aury J.M."/>
                <person name="Bento P."/>
                <person name="Bernard M."/>
                <person name="Bocs S."/>
                <person name="Campa C."/>
                <person name="Cenci A."/>
                <person name="Combes M.C."/>
                <person name="Crouzillat D."/>
                <person name="Da Silva C."/>
                <person name="Daddiego L."/>
                <person name="De Bellis F."/>
                <person name="Dussert S."/>
                <person name="Garsmeur O."/>
                <person name="Gayraud T."/>
                <person name="Guignon V."/>
                <person name="Jahn K."/>
                <person name="Jamilloux V."/>
                <person name="Joet T."/>
                <person name="Labadie K."/>
                <person name="Lan T."/>
                <person name="Leclercq J."/>
                <person name="Lepelley M."/>
                <person name="Leroy T."/>
                <person name="Li L.T."/>
                <person name="Librado P."/>
                <person name="Lopez L."/>
                <person name="Munoz A."/>
                <person name="Noel B."/>
                <person name="Pallavicini A."/>
                <person name="Perrotta G."/>
                <person name="Poncet V."/>
                <person name="Pot D."/>
                <person name="Priyono X."/>
                <person name="Rigoreau M."/>
                <person name="Rouard M."/>
                <person name="Rozas J."/>
                <person name="Tranchant-Dubreuil C."/>
                <person name="VanBuren R."/>
                <person name="Zhang Q."/>
                <person name="Andrade A.C."/>
                <person name="Argout X."/>
                <person name="Bertrand B."/>
                <person name="de Kochko A."/>
                <person name="Graziosi G."/>
                <person name="Henry R.J."/>
                <person name="Jayarama X."/>
                <person name="Ming R."/>
                <person name="Nagai C."/>
                <person name="Rounsley S."/>
                <person name="Sankoff D."/>
                <person name="Giuliano G."/>
                <person name="Albert V.A."/>
                <person name="Wincker P."/>
                <person name="Lashermes P."/>
            </authorList>
            <dbReference type="PubMed" id="25190796"/>
            <dbReference type="DOI" id="10.1126/science.1255274"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">cv. DH200-94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG739089">
        <property type="protein sequence ID" value="CDP00202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068TW28"/>
    <dbReference type="FunCoup" id="A0A068TW28">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="49390.A0A068TW28"/>
    <dbReference type="Gramene" id="CDP00202">
        <property type="protein sequence ID" value="CDP00202"/>
        <property type="gene ID" value="GSCOC_T00032072001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A068TW28"/>
    <dbReference type="OMA" id="CCHATVS"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="PhylomeDB" id="A0A068TW28"/>
    <dbReference type="Proteomes" id="UP000295252">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037981">
        <property type="entry name" value="NCS2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDP00202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000295252"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58124" checksum="D3AE68EA9AA675E2" modified="2014-10-01" version="1">MAGGGGAAAPPPKQDELQPHPVKDQLPNVSYCITSPPPWPEAIILGFQHYLVMLGTTVLIPTTLVPQMGGGNEEKAKMIQTLLFVAGLNTLTQTFFGTRLPAVIGGSYTFVPTTLSIVLAGRYSSIPEPQERFQKIMRGIQGAMIVASTLQIIIGFSGLWRNVTRFMSPLSAIPLVALSGFGLYEFGFPLLAKCVEIGLPQLILLVIFSQYMPHLTKGGRHVFDRFAVLFSVVIVWIYAHLLTVGGAYKNTPQKTQLTCRTDRAGIVGAAPWIRLPYPFQWGPPTFDAGEAFAMMAASFVALVESTGTFMAVARYASATPVPPSVLSRGVGWQGIGILLSGMFGTGNGSSVSVENAGLLAVTRVGSRRVVQISAGFMIFFSILGKFGAIFASIPAPIVAALYCLFFAYVGSAGLSYLQFCNLNSFRTKFILGFSVFMGLSVPQYFNEYTAVNGMGPVHTRARWFNDMINVPFSSEAFVAGLLALLLDVTLHKKGSATSRDRGLPWWDRFRSYKSDTRSEEFYSLPCNLNKFFPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068TWT4</accession>
    <name>A0A068TWT4_COFCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSCOC_T00032809001</nam
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